                       SEQUENCE LISTING

<110>  BioMarin Technologies B.V.

<120>  Antisense oligonucleotides

<130>  105324PC

<160>  16353
<210>  1
<211>  3685
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  2
<211>  233
<212>  RNA
<213>  Homo sapiens

<220>
<223>  Exon 51

<400>  2
cuccuacuca gacuguuacu cuggugacac aaccuguggu                            40
uacuaaggaa acugccaucu ccaaacuaga aaugccaucu                            80
uccuugaugu uggagguacc ugcucuggca gauuucaacc                            120
gggcuuggac agaacuuacc gacuggcuuu cucugcuuga                            160
ucaaguuaua aaaucacaga gggugauggu gggugaccuu                            200
gaggauauca acgagaugau caucaagcag aag                                   233

<210>  3
<211>  11
<212>  RNA
<213>  Homo sapiens

<220>
<223>  Exon Splicing Enhancer

<400>  3
ggacagaacu u                                                           11

<210>  4
<211>  6
<212>  RNA
<213>  Homo sapiens

<220>
<223>  Exon Splicing Enhancer

<400>  4
aucuuc                                                                 6

<210>  5
<211>  11
<212>  RNA
<213>  Homo sapiens

<220>
<223>  Exon Splicing Enhancer

<400>  5
aaguucuguc c                                                           11

<210>  6
<211>  6
<212>  RNA
<213>  Homo sapiens

<220>
<223>  Exon Splicing Enhancer

<400>  6
gaagau                                                                 6

<210>  7
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Drisapersen

<400>  7
ucaaggaaga uggcauuucu                                                  20

<210>  8
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Eteplirsen

<400>  8
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
tgaaaataag ctcaagcaga caaatc                                           26

<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
gacgcctctg ttccaaatcc                                                  20

<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
cagtggataa aggcaaca                                                    18

<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
gtgatggtgg gtgaccttga g                                                21

<210>  13
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
caagcagaag gcaacaa                                                     17

<210>  14
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  14
gguaaguucu guccaagc                                                    18

<210>  15
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  15
guaaguucug uccaagcc                                                    18

<210>  16
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  16
agucgguaag uucugucc                                                    18

<210>  17
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  17
cuguccaagc ccgguuga                                                    18

<210>  18
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  18
uaaguucugu ccaag                                                       15

<210>  19
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  19
uucuguccaa gcccgguuga                                                  20

<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  20
uucuguccaa gcccgguug                                                   19

<210>  21
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  21
uucuguccaa gcccgguu                                                    18

<210>  22
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  22
uucuguccaa gcccggu                                                     17

<210>  23
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  23
uucuguccaa gcccgg                                                      16

<210>  24
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  24
uucuguccaa gcccg                                                       15

<210>  25
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  25
uucuguccaa gccc                                                        14

<210>  26
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  26
uucuguccaa gcc                                                         13

<210>  27
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  27
uucuguccaa gc                                                          12

<210>  28
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  28
uucuguccaa g                                                           11

<210>  29
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  29
uucuguccaa                                                             10

<210>  30
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  30
uucugucca                                                              9

<210>  31
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  31
uucugucc                                                               8

<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  32
ucuguccaag cccgguuga                                                   19

<210>  33
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  33
ucuguccaag cccgguug                                                    18

<210>  34
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  34
ucuguccaag cccgguu                                                     17

<210>  35
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  35
ucuguccaag cccggu                                                      16

<210>  36
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  36
ucuguccaag cccgg                                                       15

<210>  37
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  37
ucuguccaag cccg                                                        14

<210>  38
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  38
ucuguccaag ccc                                                         13

<210>  39
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  39
ucuguccaag cc                                                          12

<210>  40
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  40
ucuguccaag c                                                           11

<210>  41
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  41
ucuguccaag                                                             10

<210>  42
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  42
ucuguccaa                                                              9

<210>  43
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  43
ucugucca                                                               8

<210>  44
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  44
cuguccaagc ccgguug                                                     17

<210>  45
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  45
cuguccaagc ccgguu                                                      16

<210>  46
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  46
cuguccaagc ccggu                                                       15

<210>  47
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  47
cuguccaagc ccgg                                                        14

<210>  48
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  48
cuguccaagc ccg                                                         13

<210>  49
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  49
cuguccaagc cc                                                          12

<210>  50
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  50
cuguccaagc c                                                           11

<210>  51
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  51
cuguccaagc                                                             10

<210>  52
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  52
cuguccaag                                                              9

<210>  53
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  53
cuguccaa                                                               8

<210>  54
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  54
guucugucca agcccgguug                                                  20

<210>  55
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  55
guucugucca agcccgguu                                                   19

<210>  56
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  56
guucugucca agcccggu                                                    18

<210>  57
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  57
guucugucca agcccgg                                                     17

<210>  58
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  58
guucugucca agcccg                                                      16

<210>  59
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  59
guucugucca agccc                                                       15

<210>  60
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  60
guucugucca agcc                                                        14

<210>  61
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  61
guucugucca agc                                                         13

<210>  62
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  62
guucugucca ag                                                          12

<210>  63
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  63
guucugucca a                                                           11

<210>  64
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  64
guucugucca                                                             10

<210>  65
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  65
guucugucc                                                              9

<210>  66
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  66
guucuguc                                                               8

<210>  67
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  67
aguucugucc aagcccgguu                                                  20

<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  68
aguucugucc aagcccggu                                                   19

<210>  69
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  69
aguucugucc aagcccgg                                                    18

<210>  70
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  70
aguucugucc aagcccg                                                     17

<210>  71
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  71
aguucugucc aagccc                                                      16

<210>  72
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  72
aguucugucc aagcc                                                       15

<210>  73
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  73
aguucugucc aagc                                                        14

<210>  74
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  74
aguucugucc aag                                                         13

<210>  75
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  75
aguucugucc aa                                                          12

<210>  76
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  76
aguucugucc a                                                           11

<210>  77
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  77
aguucugucc                                                             10

<210>  78
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  78
aguucuguc                                                              9

<210>  79
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  79
aguucugu                                                               8

<210>  80
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  80
aaguucuguc caagcccggu                                                  20

<210>  81
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  81
aaguucuguc caagcccgg                                                   19

<210>  82
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  82
aaguucuguc caagcccg                                                    18

<210>  83
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  83
aaguucuguc caagccc                                                     17

<210>  84
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  84
aaguucuguc caagcc                                                      16

<210>  85
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  85
aaguucuguc caagc                                                       15

<210>  86
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  86
aaguucuguc caag                                                        14

<210>  87
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  87
aaguucuguc caa                                                         13

<210>  88
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  88
aaguucuguc ca                                                          12

<210>  89
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  89
aaguucuguc c                                                           11

<210>  90
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  90
aaguucuguc                                                             10

<210>  91
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  91
aaguucugu                                                              9

<210>  92
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  92
aaguucug                                                               8

<210>  93
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  93
uaaguucugu ccaagcccgg                                                  20

<210>  94
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  94
uaaguucugu ccaagcccg                                                   19

<210>  95
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  95
uaaguucugu ccaagccc                                                    18

<210>  96
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  96
uaaguucugu ccaagcc                                                     17

<210>  97
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  97
uaaguucugu ccaagc                                                      16

<210>  98
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  98
uaaguucugu ccaa                                                        14

<210>  99
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  99
uaaguucugu cca                                                         13

<210>  100
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  100
uaaguucugu cc                                                          12

<210>  101
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  101
uaaguucugu c                                                           11

<210>  102
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  102
uaaguucugu                                                             10

<210>  103
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  103
uaaguucug                                                              9

<210>  104
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  104
uaaguucu                                                               8

<210>  105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  105
guaaguucug uccaagcccg                                                  20

<210>  106
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  106
guaaguucug uccaagccc                                                   19

<210>  107
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  107
guaaguucug uccaagc                                                     17

<210>  108
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  108
guaaguucug uccaag                                                      16

<210>  109
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  109
guaaguucug uccaa                                                       15

<210>  110
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  110
guaaguucug ucca                                                        14

<210>  111
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  111
guaaguucug ucc                                                         13

<210>  112
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  112
guaaguucug uc                                                          12

<210>  113
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  113
guaaguucug u                                                           11

<210>  114
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  114
guaaguucug                                                             10

<210>  115
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  115
guaaguucu                                                              9

<210>  116
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  116
guaaguuc                                                               8

<210>  117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  117
gguaaguucu guccaagccc                                                  20

<210>  118
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  118
gguaaguucu guccaagcc                                                   19

<210>  119
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  119
gguaaguucu guccaag                                                     17

<210>  120
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  120
gguaaguucu guccaa                                                      16

<210>  121
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  121
gguaaguucu gucca                                                       15

<210>  122
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  122
gguaaguucu gucc                                                        14

<210>  123
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  123
gguaaguucu guc                                                         13

<210>  124
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  124
gguaaguucu gu                                                          12

<210>  125
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  125
gguaaguucu g                                                           11

<210>  126
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  126
gguaaguucu                                                             10

<210>  127
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  127
gguaaguuc                                                              9

<210>  128
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  128
gguaaguu                                                               8

<210>  129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  129
cgguaaguuc uguccaagcc                                                  20

<210>  130
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  130
cgguaaguuc uguccaagc                                                   19

<210>  131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  131
cgguaaguuc uguccaag                                                    18

<210>  132
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  132
cgguaaguuc uguccaa                                                     17

<210>  133
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  133
cgguaaguuc ugucca                                                      16

<210>  134
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  134
cgguaaguuc ugucc                                                       15

<210>  135
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  135
cgguaaguuc uguc                                                        14

<210>  136
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  136
cgguaaguuc ugu                                                         13

<210>  137
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  137
cgguaaguuc ug                                                          12

<210>  138
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  138
cgguaaguuc u                                                           11

<210>  139
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  139
cgguaaguuc                                                             10

<210>  140
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  140
cgguaaguu                                                              9

<210>  141
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  141
cgguaagu                                                               8

<210>  142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  142
ucgguaaguu cuguccaagc                                                  20

<210>  143
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  143
ucgguaaguu cuguccaag                                                   19

<210>  144
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  144
ucgguaaguu cuguccaa                                                    18

<210>  145
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  145
ucgguaaguu cugucca                                                     17

<210>  146
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  146
ucgguaaguu cugucc                                                      16

<210>  147
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  147
ucgguaaguu cuguc                                                       15

<210>  148
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  148
ucgguaaguu cugu                                                        14

<210>  149
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  149
ucgguaaguu cug                                                         13

<210>  150
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  150
ucgguaaguu cu                                                          12

<210>  151
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  151
ucgguaaguu c                                                           11

<210>  152
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  152
ucgguaaguu                                                             10

<210>  153
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  153
ucgguaagu                                                              9

<210>  154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  154
gucgguaagu ucuguccaag                                                  20

<210>  155
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  155
gucgguaagu ucuguccaa                                                   19

<210>  156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  156
gucgguaagu ucugucca                                                    18

<210>  157
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  157
gucgguaagu ucugucc                                                     17

<210>  158
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  158
gucgguaagu ucuguc                                                      16

<210>  159
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  159
gucgguaagu ucugu                                                       15

<210>  160
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  160
gucgguaagu ucug                                                        14

<210>  161
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  161
gucgguaagu ucu                                                         13

<210>  162
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  162
gucgguaagu uc                                                          12

<210>  163
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  163
gucgguaagu u                                                           11

<210>  164
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  164
gucgguaagu                                                             10

<210>  165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  165
agucgguaag uucuguccaa                                                  20

<210>  166
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  166
agucgguaag uucugucca                                                   19

<210>  167
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  167
agucgguaag uucuguc                                                     17

<210>  168
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  168
agucgguaag uucugu                                                      16

<210>  169
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  169
agucgguaag uucug                                                       15

<210>  170
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  170
agucgguaag uucu                                                        14

<210>  171
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  171
agucgguaag uuc                                                         13

<210>  172
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  172
agucgguaag uu                                                          12

<210>  173
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  173
agucgguaag u                                                           11

<210>  174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  174
cagucgguaa guucugucca                                                  20

<210>  175
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  175
cagucgguaa guucugucc                                                   19

<210>  176
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  176
cagucgguaa guucuguc                                                    18

<210>  177
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  177
cagucgguaa guucugu                                                     17

<210>  178
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  178
cagucgguaa guucug                                                      16

<210>  179
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  179
cagucgguaa guucu                                                       15

<210>  180
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  180
cagucgguaa guuc                                                        14

<210>  181
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  181
cagucgguaa guu                                                         13

<210>  182
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  182
cagucgguaa gu                                                          12

<210>  183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  183
ccagucggua aguucugucc                                                  20

<210>  184
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  184
ccagucggua aguucuguc                                                   19

<210>  185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  185
ccagucggua aguucugu                                                    18

<210>  186
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  186
ccagucggua aguucug                                                     17

<210>  187
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  187
ccagucggua aguucu                                                      16

<210>  188
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  188
ccagucggua aguuc                                                       15

<210>  189
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  189
ccagucggua aguu                                                        14

<210>  190
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  190
ccagucggua agu                                                         13

<210>  191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  191
gccagucggu aaguucuguc                                                  20

<210>  192
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  192
gccagucggu aaguucugu                                                   19

<210>  193
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  193
gccagucggu aaguucug                                                    18

<210>  194
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  194
gccagucggu aaguucu                                                     17

<210>  195
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  195
gccagucggu aaguuc                                                      16

<210>  196
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  196
gccagucggu aaguu                                                       15

<210>  197
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  197
gccagucggu aagu                                                        14

<210>  198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  198
ucaaggaaga uggcauuucu                                                  20

<210>  199
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  199
ucaaggaaga uggcauuucu ag                                               22

<210>  200
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  200
ucaaggaaga uggcau                                                      16

<210>  201
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  201
gaagauggca uuucu                                                       15

<210>  202
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  202
ucaaggaaga uggcauuucu a                                                21

<210>  203
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  203
ucaaggaaga uggcauuuc                                                   19

<210>  204
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  204
ucaaggaaga uggcauuu                                                    18

<210>  205
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  205
ucaaggaaga uggcauu                                                     17

<210>  206
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  206
ucaaggaaga uggca                                                       15

<210>  207
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  207
ucaaggaaga uggc                                                        14

<210>  208
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  208
ucaaggaaga ugg                                                         13

<210>  209
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  209
ucaaggaaga ug                                                          12

<210>  210
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  210
ucaaggaaga u                                                           11

<210>  211
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  211
ucaaggaaga                                                             10

<210>  212
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  212
ucaaggaag                                                              9

<210>  213
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  213
caaggaagau ggcauuucua g                                                21

<210>  214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  214
caaggaagau ggcauuucua                                                  20

<210>  215
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  215
caaggaagau ggcauuucu                                                   19

<210>  216
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  216
caaggaagau ggcauuuc                                                    18

<210>  217
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  217
caaggaagau ggcauuu                                                     17

<210>  218
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  218
caaggaagau ggcauu                                                      16

<210>  219
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  219
caaggaagau ggcau                                                       15

<210>  220
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  220
caaggaagau ggca                                                        14

<210>  221
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  221
caaggaagau ggc                                                         13

<210>  222
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  222
caaggaagau gg                                                          12

<210>  223
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  223
caaggaagau g                                                           11

<210>  224
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  224
caaggaagau                                                             10

<210>  225
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  225
caaggaaga                                                              9

<210>  226
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  226
caaggaag                                                               8

<210>  227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  227
aaggaagaug gcauuucuag                                                  20

<210>  228
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  228
aaggaagaug gcauuucua                                                   19

<210>  229
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  229
aaggaagaug gcauuucu                                                    18

<210>  230
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  230
aaggaagaug gcauuuc                                                     17

<210>  231
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  231
aaggaagaug gcauuu                                                      16

<210>  232
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  232
aaggaagaug gcauu                                                       15

<210>  233
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  233
aaggaagaug gcau                                                        14

<210>  234
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  234
aaggaagaug gca                                                         13

<210>  235
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  235
aaggaagaug gc                                                          12

<210>  236
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  236
aaggaagaug g                                                           11

<210>  237
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  237
aaggaagaug                                                             10

<210>  238
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  238
aaggaagau                                                              9

<210>  239
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  239
aaggaaga                                                               8

<210>  240
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  240
aggaagaugg cauuucuag                                                   19

<210>  241
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  241
aggaagaugg cauuucua                                                    18

<210>  242
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  242
aggaagaugg cauuucu                                                     17

<210>  243
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  243
aggaagaugg cauuuc                                                      16

<210>  244
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  244
aggaagaugg cauuu                                                       15

<210>  245
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  245
aggaagaugg cauu                                                        14

<210>  246
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  246
aggaagaugg cau                                                         13

<210>  247
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  247
aggaagaugg ca                                                          12

<210>  248
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  248
aggaagaugg                                                             10

<210>  249
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  249
aggaagaug                                                              9

<210>  250
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  250
aggaagau                                                               8

<210>  251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  251
ggaagauggc auuucuag                                                    18

<210>  252
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  252
ggaagauggc auuucua                                                     17

<210>  253
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  253
ggaagauggc auuucu                                                      16

<210>  254
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  254
ggaagauggc auuuc                                                       15

<210>  255
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  255
ggaagauggc auuu                                                        14

<210>  256
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  256
ggaagauggc auu                                                         13

<210>  257
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  257
ggaagauggc au                                                          12

<210>  258
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  258
ggaagauggc a                                                           11

<210>  259
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  259
ggaagauggc                                                             10

<210>  260
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  260
ggaagaug                                                               8

<210>  261
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  261
gaagauggca uuucuag                                                     17

<210>  262
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  262
gaagauggca uuucua                                                      16

<210>  263
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  263
gaagauggca uuuc                                                        14

<210>  264
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  264
gaagauggca uuu                                                         13

<210>  265
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  265
gaagauggca uu                                                          12

<210>  266
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  266
gaagauggca u                                                           11

<210>  267
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  267
gaagauggca                                                             10

<210>  268
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  268
gaagauggc                                                              9

<210>  269
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  269
gaagaugg                                                               8

<210>  270
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  270
aagauggcau uucuag                                                      16

<210>  271
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  271
aagauggcau uucua                                                       15

<210>  272
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  272
aagauggcau uucu                                                        14

<210>  273
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  273
aagauggcau uuc                                                         13

<210>  274
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  274
aagauggcau uu                                                          12

<210>  275
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  275
aagauggcau u                                                           11

<210>  276
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  276
aagauggcau                                                             10

<210>  277
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  277
aagauggca                                                              9

<210>  278
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  278
aagauggc                                                               8

<210>  279
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  279
agauggcauu ucuag                                                       15

<210>  280
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  280
agauggcauu ucua                                                        14

<210>  281
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  281
agauggcauu ucu                                                         13

<210>  282
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  282
agauggcauu uc                                                          12

<210>  283
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  283
agauggcauu u                                                           11

<210>  284
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  284
agauggcauu                                                             10

<210>  285
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  285
agauggcau                                                              9

<210>  286
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  286
agauggca                                                               8

<210>  287
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  287
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  288
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  288
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  289
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  289
cuccaacauc aaggaagaug gcauuucu                                         28

<210>  290
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  290
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  291
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  291
cuccaacauc aaggaagaug gcauuu                                           26

<210>  292
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  292
cuccaacauc aaggaagaug gcauu                                            25

<210>  293
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  293
cuccaacauc aaggaagaug gcau                                             24

<210>  294
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  294
cuccaacauc aaggaagaug gca                                              23

<210>  295
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  295
cuccaacauc aaggaagaug gc                                               22

<210>  296
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  296
cuccaacauc aaggaagaug g                                                21

<210>  297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  297
cuccaacauc aaggaagaug                                                  20

<210>  298
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  298
cuccaacauc aaggaagau                                                   19

<210>  299
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  299
cuccaacauc aaggaaga                                                    18

<210>  300
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  300
cuccaacauc aaggaag                                                     17

<210>  301
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  301
uccaacauca aggaagaugg cauuucuag                                        29

<210>  302
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  302
uccaacauca aggaagaugg cauuucua                                         28

<210>  303
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  303
uccaacauca aggaagaugg cauuucu                                          27

<210>  304
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  304
uccaacauca aggaagaugg cauuuc                                           26

<210>  305
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  305
uccaacauca aggaagaugg cauuu                                            25

<210>  306
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  306
uccaacauca aggaagaugg cauu                                             24

<210>  307
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  307
uccaacauca aggaagaugg cau                                              23

<210>  308
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  308
uccaacauca aggaagaugg ca                                               22

<210>  309
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  309
uccaacauca aggaagaugg c                                                21

<210>  310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  310
uccaacauca aggaagaugg                                                  20

<210>  311
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  311
uccaacauca aggaagaug                                                   19

<210>  312
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  312
uccaacauca aggaagau                                                    18

<210>  313
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  313
uccaacauca aggaaga                                                     17

<210>  314
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  314
uccaacauca aggaag                                                      16

<210>  315
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  315
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  316
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  316
ccaacaucaa ggaagauggc auuucua                                          27

<210>  317
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  317
ccaacaucaa ggaagauggc auuucu                                           26

<210>  318
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  318
ccaacaucaa ggaagauggc auuuc                                            25

<210>  319
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  319
ccaacaucaa ggaagauggc auuu                                             24

<210>  320
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  320
ccaacaucaa ggaagauggc auu                                              23

<210>  321
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  321
ccaacaucaa ggaagauggc au                                               22

<210>  322
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  322
ccaacaucaa ggaagauggc a                                                21

<210>  323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  323
ccaacaucaa ggaagauggc                                                  20

<210>  324
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  324
ccaacaucaa ggaagaugg                                                   19

<210>  325
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  325
ccaacaucaa ggaagaug                                                    18

<210>  326
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  326
ccaacaucaa ggaagau                                                     17

<210>  327
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  327
ccaacaucaa ggaaga                                                      16

<210>  328
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  328
ccaacaucaa ggaag                                                       15

<210>  329
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  329
caacaucaag gaagauggca uuucuag                                          27

<210>  330
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  330
caacaucaag gaagauggca uuucua                                           26

<210>  331
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  331
caacaucaag gaagauggca uuucu                                            25

<210>  332
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  332
caacaucaag gaagauggca uuuc                                             24

<210>  333
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  333
caacaucaag gaagauggca uuu                                              23

<210>  334
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  334
caacaucaag gaagauggca uu                                               22

<210>  335
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  335
caacaucaag gaagauggca u                                                21

<210>  336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  336
caacaucaag gaagauggca                                                  20

<210>  337
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  337
caacaucaag gaagauggc                                                   19

<210>  338
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  338
caacaucaag gaagaugg                                                    18

<210>  339
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  339
caacaucaag gaagaug                                                     17

<210>  340
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  340
caacaucaag gaagau                                                      16

<210>  341
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  341
caacaucaag gaaga                                                       15

<210>  342
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  342
caacaucaag gaag                                                        14

<210>  343
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  343
aacaucaagg aagauggcau uucuag                                           26

<210>  344
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  344
aacaucaagg aagauggcau uucua                                            25

<210>  345
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  345
aacaucaagg aagauggcau uucu                                             24

<210>  346
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  346
aacaucaagg aagauggcau uuc                                              23

<210>  347
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  347
aacaucaagg aagauggcau uu                                               22

<210>  348
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  348
aacaucaagg aagauggcau u                                                21

<210>  349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  349
aacaucaagg aagauggcau                                                  20

<210>  350
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  350
aacaucaagg aagauggca                                                   19

<210>  351
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  351
aacaucaagg aagauggc                                                    18

<210>  352
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  352
aacaucaagg aagaugg                                                     17

<210>  353
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  353
aacaucaagg aagaug                                                      16

<210>  354
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  354
aacaucaagg aagau                                                       15

<210>  355
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  355
aacaucaagg aaga                                                        14

<210>  356
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  356
aacaucaagg aag                                                         13

<210>  357
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  357
acaucaagga agauggcauu ucuag                                            25

<210>  358
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  358
acaucaagga agauggcauu ucua                                             24

<210>  359
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  359
acaucaagga agauggcauu ucu                                              23

<210>  360
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  360
acaucaagga agauggcauu uc                                               22

<210>  361
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  361
acaucaagga agauggcauu u                                                21

<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  362
acaucaagga agauggcauu                                                  20

<210>  363
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  363
acaucaagga agauggcau                                                   19

<210>  364
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  364
acaucaagga agauggca                                                    18

<210>  365
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  365
acaucaagga agauggc                                                     17

<210>  366
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  366
acaucaagga agaugg                                                      16

<210>  367
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  367
acaucaagga agaug                                                       15

<210>  368
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  368
acaucaagga agau                                                        14

<210>  369
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  369
acaucaagga aga                                                         13

<210>  370
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  370
acaucaagga ag                                                          12

<210>  371
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  371
caucaaggaa gauggcauuu cuag                                             24

<210>  372
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  372
caucaaggaa gauggcauuu cua                                              23

<210>  373
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  373
caucaaggaa gauggcauuu cu                                               22

<210>  374
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  374
caucaaggaa gauggcauuu c                                                21

<210>  375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  375
caucaaggaa gauggcauuu                                                  20

<210>  376
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  376
caucaaggaa gauggcauu                                                   19

<210>  377
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  377
caucaaggaa gauggcau                                                    18

<210>  378
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  378
caucaaggaa gauggca                                                     17

<210>  379
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  379
caucaaggaa gauggc                                                      16

<210>  380
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  380
caucaaggaa gaugg                                                       15

<210>  381
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  381
caucaaggaa gaug                                                        14

<210>  382
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  382
caucaaggaa gau                                                         13

<210>  383
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  383
caucaaggaa ga                                                          12

<210>  384
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  384
caucaaggaa g                                                           11

<210>  385
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  385
aucaaggaag auggcauuuc uag                                              23

<210>  386
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  386
aucaaggaag auggcauuuc ua                                               22

<210>  387
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  387
aucaaggaag auggcauuuc u                                                21

<210>  388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  388
aucaaggaag auggcauuuc                                                  20

<210>  389
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  389
aucaaggaag auggcauuu                                                   19

<210>  390
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  390
aucaaggaag auggcauu                                                    18

<210>  391
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  391
aucaaggaag auggcau                                                     17

<210>  392
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  392
aucaaggaag auggca                                                      16

<210>  393
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  393
aucaaggaag auggc                                                       15

<210>  394
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  394
aucaaggaag augg                                                        14

<210>  395
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  395
aucaaggaag aug                                                         13

<210>  396
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  396
aucaaggaag au                                                          12

<210>  397
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  397
aucaaggaag a                                                           11

<210>  398
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  398
aucaaggaag                                                             10

<210>  399
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  399
gguaaguucu guccaagc                                                    18

<210>  400
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  400
guaaguucug uccaagcc                                                    18

<210>  401
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  401
agucgguaag uucugucc                                                    18

<210>  402
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  402
cuguccaagc ccgguuga                                                    18

<210>  403
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  403
uaaguucugu ccaag                                                       15

<210>  404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  404
uucuguccaa gcccgguuga                                                  20

<210>  405
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  405
uucuguccaa gcccgguug                                                   19

<210>  406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  406
uucuguccaa gcccgguu                                                    18

<210>  407
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  407
uucuguccaa gcccggu                                                     17

<210>  408
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  408
uucuguccaa gcccgg                                                      16

<210>  409
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  409
uucuguccaa gcccg                                                       15

<210>  410
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  410
uucuguccaa gccc                                                        14

<210>  411
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  411
uucuguccaa gcc                                                         13

<210>  412
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  412
uucuguccaa gc                                                          12

<210>  413
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  413
uucuguccaa g                                                           11

<210>  414
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  414
uucuguccaa                                                             10

<210>  415
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  415
uucugucca                                                              9

<210>  416
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  416
uucugucc                                                               8

<210>  417
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  417
ucuguccaag cccgguuga                                                   19

<210>  418
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  418
ucuguccaag cccgguug                                                    18

<210>  419
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  419
ucuguccaag cccgguu                                                     17

<210>  420
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  420
ucuguccaag cccggu                                                      16

<210>  421
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  421
ucuguccaag cccgg                                                       15

<210>  422
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  422
ucuguccaag cccg                                                        14

<210>  423
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  423
ucuguccaag ccc                                                         13

<210>  424
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  424
ucuguccaag cc                                                          12

<210>  425
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  425
ucuguccaag c                                                           11

<210>  426
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  426
ucuguccaag                                                             10

<210>  427
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  427
ucuguccaa                                                              9

<210>  428
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  428
ucugucca                                                               8

<210>  429
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  429
cuguccaagc ccgguug                                                     17

<210>  430
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  430
cuguccaagc ccgguu                                                      16

<210>  431
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  431
cuguccaagc ccggu                                                       15

<210>  432
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  432
cuguccaagc ccgg                                                        14

<210>  433
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  433
cuguccaagc ccg                                                         13

<210>  434
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  434
cuguccaagc cc                                                          12

<210>  435
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  435
cuguccaagc c                                                           11

<210>  436
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  436
cuguccaagc                                                             10

<210>  437
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<400>  437
cuguccaag                                                              9

<210>  438
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<400>  438
cuguccaa                                                               8

<210>  439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  439
guucugucca agcccgguug                                                  20

<210>  440
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  440
guucugucca agcccgguu                                                   19

<210>  441
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  441
guucugucca agcccggu                                                    18

<210>  442
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  442
guucugucca agcccgg                                                     17

<210>  443
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  443
guucugucca agcccg                                                      16

<210>  444
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  444
guucugucca agccc                                                       15

<210>  445
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  445
guucugucca agcc                                                        14

<210>  446
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  446
guucugucca agc                                                         13

<210>  447
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  447
guucugucca ag                                                          12

<210>  448
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  448
guucugucca a                                                           11

<210>  449
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  449
guucugucca                                                             10

<210>  450
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  450
guucugucc                                                              9

<210>  451
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  451
guucuguc                                                               8

<210>  452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  452
aguucugucc aagcccgguu                                                  20

<210>  453
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  453
aguucugucc aagcccggu                                                   19

<210>  454
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  454
aguucugucc aagcccgg                                                    18

<210>  455
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  455
aguucugucc aagcccg                                                     17

<210>  456
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  456
aguucugucc aagccc                                                      16

<210>  457
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  457
aguucugucc aagcc                                                       15

<210>  458
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  458
aguucugucc aagc                                                        14

<210>  459
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  459
aguucugucc aag                                                         13

<210>  460
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  460
aguucugucc aa                                                          12

<210>  461
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  461
aguucugucc a                                                           11

<210>  462
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  462
aguucugucc                                                             10

<210>  463
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  463
aguucuguc                                                              9

<210>  464
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  464
aguucugu                                                               8

<210>  465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  465
aaguucuguc caagcccggu                                                  20

<210>  466
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  466
aaguucuguc caagcccgg                                                   19

<210>  467
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  467
aaguucuguc caagcccg                                                    18

<210>  468
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  468
aaguucuguc caagccc                                                     17

<210>  469
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  469
aaguucuguc caagcc                                                      16

<210>  470
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  470
aaguucuguc caagc                                                       15

<210>  471
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  471
aaguucuguc caag                                                        14

<210>  472
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  472
aaguucuguc caa                                                         13

<210>  473
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  473
aaguucuguc ca                                                          12

<210>  474
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  474
aaguucuguc c                                                           11

<210>  475
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  475
aaguucuguc                                                             10

<210>  476
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  476
aaguucugu                                                              9

<210>  477
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  477
aaguucug                                                               8

<210>  478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  478
uaaguucugu ccaagcccgg                                                  20

<210>  479
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  479
uaaguucugu ccaagcccg                                                   19

<210>  480
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  480
uaaguucugu ccaagccc                                                    18

<210>  481
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  481
uaaguucugu ccaagcc                                                     17

<210>  482
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  482
uaaguucugu ccaagc                                                      16

<210>  483
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  483
uaaguucugu ccaa                                                        14

<210>  484
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  484
uaaguucugu cca                                                         13

<210>  485
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  485
uaaguucugu cc                                                          12

<210>  486
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  486
uaaguucugu c                                                           11

<210>  487
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  487
uaaguucugu                                                             10

<210>  488
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  488
uaaguucug                                                              9

<210>  489
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  489
uaaguucu                                                               8

<210>  490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  490
guaaguucug uccaagcccg                                                  20

<210>  491
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  491
guaaguucug uccaagccc                                                   19

<210>  492
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  492
guaaguucug uccaagc                                                     17

<210>  493
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  493
guaaguucug uccaag                                                      16

<210>  494
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  494
guaaguucug uccaa                                                       15

<210>  495
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  495
guaaguucug ucca                                                        14

<210>  496
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  496
guaaguucug ucc                                                         13

<210>  497
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  497
guaaguucug uc                                                          12

<210>  498
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  498
guaaguucug u                                                           11

<210>  499
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  499
guaaguucug                                                             10

<210>  500
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  500
guaaguucu                                                              9

<210>  501
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  501
guaaguuc                                                               8

<210>  502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  502
gguaaguucu guccaagccc                                                  20

<210>  503
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  503
gguaaguucu guccaagcc                                                   19

<210>  504
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  504
gguaaguucu guccaag                                                     17

<210>  505
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  505
gguaaguucu guccaa                                                      16

<210>  506
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  506
gguaaguucu gucca                                                       15

<210>  507
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  507
gguaaguucu gucc                                                        14

<210>  508
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  508
gguaaguucu guc                                                         13

<210>  509
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  509
gguaaguucu gu                                                          12

<210>  510
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  510
gguaaguucu g                                                           11

<210>  511
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  511
gguaaguucu                                                             10

<210>  512
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  512
gguaaguuc                                                              9

<210>  513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<400>  513
cgguaaguuc uguccaagcc                                                  20

<210>  514
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  514
cgguaaguuc uguccaagc                                                   19

<210>  515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  515
cgguaaguuc uguccaag                                                    18

<210>  516
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  516
cgguaaguuc uguccaa                                                     17

<210>  517
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  517
cgguaaguuc ugucca                                                      16

<210>  518
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  518
cgguaaguuc ugucc                                                       15

<210>  519
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  519
cgguaaguuc uguc                                                        14

<210>  520
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  520
cgguaaguuc ugu                                                         13

<210>  521
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  521
cgguaaguuc ug                                                          12

<210>  522
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  522
cgguaaguuc u                                                           11

<210>  523
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  523
cgguaaguuc                                                             10

<210>  524
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  524
cgguaaguu                                                              9

<210>  525
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  525
cgguaagu                                                               8

<210>  526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  526
ucgguaaguu cuguccaagc                                                  20

<210>  527
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  527
ucgguaaguu cuguccaag                                                   19

<210>  528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  528
ucgguaaguu cuguccaa                                                    18

<210>  529
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  529
ucgguaaguu cugucca                                                     17

<210>  530
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  530
ucgguaaguu cugucc                                                      16

<210>  531
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  531
ucgguaaguu cuguc                                                       15

<210>  532
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  532
ucgguaaguu cugu                                                        14

<210>  533
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  533
ucgguaaguu cug                                                         13

<210>  534
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  534
ucgguaaguu cu                                                          12

<210>  535
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  535
ucgguaaguu c                                                           11

<210>  536
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  536
ucgguaaguu                                                             10

<210>  537
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  537
ucgguaagu                                                              9

<210>  538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  538
gucgguaagu ucuguccaag                                                  20

<210>  539
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  539
gucgguaagu ucuguccaa                                                   19

<210>  540
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  540
gucgguaagu ucugucca                                                    18

<210>  541
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  541
gucgguaagu ucugucc                                                     17

<210>  542
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  542
gucgguaagu ucuguc                                                      16

<210>  543
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  543
gucgguaagu ucugu                                                       15

<210>  544
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  544
gucgguaagu ucug                                                        14

<210>  545
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  545
gucgguaagu ucu                                                         13

<210>  546
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  546
gucgguaagu uc                                                          12

<210>  547
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  547
gucgguaagu u                                                           11

<210>  548
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  548
gucgguaagu                                                             10

<210>  549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  549
agucgguaag uucuguccaa                                                  20

<210>  550
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  550
agucgguaag uucugucca                                                   19

<210>  551
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  551
agucgguaag uucuguc                                                     17

<210>  552
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  552
agucgguaag uucugu                                                      16

<210>  553
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  553
agucgguaag uucug                                                       15

<210>  554
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  554
agucgguaag uucu                                                        14

<210>  555
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  555
agucgguaag uuc                                                         13

<210>  556
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  556
agucgguaag uu                                                          12

<210>  557
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  557
agucgguaag u                                                           11

<210>  558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  558
cagucgguaa guucugucca                                                  20

<210>  559
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  559
cagucgguaa guucugucc                                                   19

<210>  560
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  560
cagucgguaa guucuguc                                                    18

<210>  561
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  561
cagucgguaa guucugu                                                     17

<210>  562
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  562
cagucgguaa guucug                                                      16

<210>  563
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  563
cagucgguaa guucu                                                       15

<210>  564
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  564
cagucgguaa guuc                                                        14

<210>  565
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  565
cagucgguaa guu                                                         13

<210>  566
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  566
cagucgguaa gu                                                          12

<210>  567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<400>  567
ccagucggua aguucugucc                                                  20

<210>  568
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  568
ccagucggua aguucuguc                                                   19

<210>  569
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  569
ccagucggua aguucugu                                                    18

<210>  570
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  570
ccagucggua aguucug                                                     17

<210>  571
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  571
ccagucggua aguucu                                                      16

<210>  572
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  572
ccagucggua aguuc                                                       15

<210>  573
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  573
ccagucggua aguu                                                        14

<210>  574
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  574
ccagucggua agu                                                         13

<210>  575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  575
gccagucggu aaguucuguc                                                  20

<210>  576
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  576
gccagucggu aaguucugu                                                   19

<210>  577
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  577
gccagucggu aaguucug                                                    18

<210>  578
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  578
gccagucggu aaguucu                                                     17

<210>  579
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  579
gccagucggu aaguuc                                                      16

<210>  580
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  580
gccagucggu aaguu                                                       15

<210>  581
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  581
gccagucggu aagu                                                        14

<210>  582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  582
ucaaggaaga uggcauuucu                                                  20

<210>  583
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  583
ucaaggaaga uggcauuucu ag                                               22

<210>  584
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  584
ucaaggaaga uggcau                                                      16

<210>  585
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  585
gaagauggca uuucu                                                       15

<210>  586
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  586
ucaaggaaga uggcauuucu a                                                21

<210>  587
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  587
ucaaggaaga uggcauuuc                                                   19

<210>  588
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  588
ucaaggaaga uggcauuu                                                    18

<210>  589
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  589
ucaaggaaga uggcauu                                                     17

<210>  590
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  590
ucaaggaaga uggca                                                       15

<210>  591
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  591
ucaaggaaga uggc                                                        14

<210>  592
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  592
ucaaggaaga ugg                                                         13

<210>  593
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  593
ucaaggaaga ug                                                          12

<210>  594
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  594
ucaaggaaga u                                                           11

<210>  595
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  595
ucaaggaaga                                                             10

<210>  596
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  596
ucaaggaag                                                              9

<210>  597
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  597
caaggaagau ggcauuucua g                                                21

<210>  598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  598
caaggaagau ggcauuucua                                                  20

<210>  599
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  599
caaggaagau ggcauuucu                                                   19

<210>  600
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  600
caaggaagau ggcauuuc                                                    18

<210>  601
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  601
caaggaagau ggcauuu                                                     17

<210>  602
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  602
caaggaagau ggcauu                                                      16

<210>  603
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  603
caaggaagau ggcau                                                       15

<210>  604
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  604
caaggaagau ggca                                                        14

<210>  605
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  605
caaggaagau ggc                                                         13

<210>  606
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  606
caaggaagau gg                                                          12

<210>  607
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  607
caaggaagau g                                                           11

<210>  608
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  608
caaggaagau                                                             10

<210>  609
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  609
caaggaaga                                                              9

<210>  610
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  610
caaggaag                                                               8

<210>  611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  611
aaggaagaug gcauuucuag                                                  20

<210>  612
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  612
aaggaagaug gcauuucua                                                   19

<210>  613
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  613
aaggaagaug gcauuucu                                                    18

<210>  614
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  614
aaggaagaug gcauuuc                                                     17

<210>  615
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  615
aaggaagaug gcauuu                                                      16

<210>  616
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  616
aaggaagaug gcauu                                                       15

<210>  617
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  617
aaggaagaug gcau                                                        14

<210>  618
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  618
aaggaagaug gca                                                         13

<210>  619
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  619
aaggaagaug gc                                                          12

<210>  620
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  620
aggaagaugg cauuucuag                                                   19

<210>  621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  621
aggaagaugg cauuucua                                                    18

<210>  622
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  622
aggaagaugg cauuucu                                                     17

<210>  623
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  623
aggaagaugg cauuuc                                                      16

<210>  624
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  624
aggaagaugg cauuu                                                       15

<210>  625
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  625
aggaagaugg cauu                                                        14

<210>  626
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  626
aggaagaugg cau                                                         13

<210>  627
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  627
aggaagaugg ca                                                          12

<210>  628
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  628
ggaagauggc auuucuag                                                    18

<210>  629
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  629
ggaagauggc auuucua                                                     17

<210>  630
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  630
ggaagauggc auuucu                                                      16

<210>  631
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  631
ggaagauggc auuuc                                                       15

<210>  632
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  632
ggaagauggc auuu                                                        14

<210>  633
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  633
ggaagauggc auu                                                         13

<210>  634
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  634
ggaagauggc au                                                          12

<210>  635
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  635
ggaagauggc a                                                           11

<210>  636
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  636
ggaagauggc                                                             10

<210>  637
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  637
gaagauggca uuucuag                                                     17

<210>  638
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  638
gaagauggca uuucua                                                      16

<210>  639
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  639
gaagauggca uuuc                                                        14

<210>  640
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  640
gaagauggca uuu                                                         13

<210>  641
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  641
gaagauggca uu                                                          12

<210>  642
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  642
gaagauggca u                                                           11

<210>  643
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  643
gaagauggca                                                             10

<210>  644
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  644
gaagauggc                                                              9

<210>  645
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  645
aagauggcau uucuag                                                      16

<210>  646
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  646
aagauggcau uucua                                                       15

<210>  647
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  647
aagauggcau uucu                                                        14

<210>  648
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  648
aagauggcau uuc                                                         13

<210>  649
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  649
aagauggcau uu                                                          12

<210>  650
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  650
aagauggcau u                                                           11

<210>  651
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  651
aagauggcau                                                             10

<210>  652
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  652
aagauggca                                                              9

<210>  653
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  653
aagauggc                                                               8

<210>  654
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  654
agauggcauu ucuag                                                       15

<210>  655
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  655
agauggcauu ucua                                                        14

<210>  656
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  656
agauggcauu ucu                                                         13

<210>  657
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  657
agauggcauu uc                                                          12

<210>  658
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  658
agauggcauu u                                                           11

<210>  659
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  659
agauggcauu                                                             10

<210>  660
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  660
agauggcau                                                              9

<210>  661
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  661
agauggca                                                               8

<210>  662
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  662
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  663
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  663
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  664
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  664
cuccaacauc aaggaagaug gcauuucu                                         28

<210>  665
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  665
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  666
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  666
cuccaacauc aaggaagaug gcauuu                                           26

<210>  667
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  667
cuccaacauc aaggaagaug gcauu                                            25

<210>  668
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  668
cuccaacauc aaggaagaug gcau                                             24

<210>  669
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  669
cuccaacauc aaggaagaug gca                                              23

<210>  670
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  670
cuccaacauc aaggaagaug gc                                               22

<210>  671
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  671
cuccaacauc aaggaagaug g                                                21

<210>  672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  672
cuccaacauc aaggaagaug                                                  20

<210>  673
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  673
cuccaacauc aaggaagau                                                   19

<210>  674
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  674
cuccaacauc aaggaaga                                                    18

<210>  675
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  675
cuccaacauc aaggaag                                                     17

<210>  676
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  676
uccaacauca aggaagaugg cauuucuag                                        29

<210>  677
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  677
uccaacauca aggaagaugg cauuucua                                         28

<210>  678
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  678
uccaacauca aggaagaugg cauuucu                                          27

<210>  679
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  679
uccaacauca aggaagaugg cauuuc                                           26

<210>  680
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  680
uccaacauca aggaagaugg cauuu                                            25

<210>  681
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  681
uccaacauca aggaagaugg cauu                                             24

<210>  682
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  682
uccaacauca aggaagaugg cau                                              23

<210>  683
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  683
uccaacauca aggaagaugg ca                                               22

<210>  684
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  684
uccaacauca aggaagaugg c                                                21

<210>  685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  685
uccaacauca aggaagaugg                                                  20

<210>  686
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  686
uccaacauca aggaagaug                                                   19

<210>  687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  687
uccaacauca aggaagau                                                    18

<210>  688
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  688
uccaacauca aggaaga                                                     17

<210>  689
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  689
uccaacauca aggaag                                                      16

<210>  690
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  690
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  691
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  691
ccaacaucaa ggaagauggc auuucua                                          27

<210>  692
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  692
ccaacaucaa ggaagauggc auuucu                                           26

<210>  693
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  693
ccaacaucaa ggaagauggc auuuc                                            25

<210>  694
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  694
ccaacaucaa ggaagauggc auuu                                             24

<210>  695
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  695
ccaacaucaa ggaagauggc auu                                              23

<210>  696
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  696
ccaacaucaa ggaagauggc au                                               22

<210>  697
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  697
ccaacaucaa ggaagauggc a                                                21

<210>  698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  698
ccaacaucaa ggaagauggc                                                  20

<210>  699
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  699
ccaacaucaa ggaagaugg                                                   19

<210>  700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  700
ccaacaucaa ggaagaug                                                    18

<210>  701
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  701
ccaacaucaa ggaagau                                                     17

<210>  702
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  702
ccaacaucaa ggaaga                                                      16

<210>  703
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  703
ccaacaucaa ggaag                                                       15

<210>  704
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  704
caacaucaag gaagauggca uuucuag                                          27

<210>  705
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  705
caacaucaag gaagauggca uuucua                                           26

<210>  706
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  706
caacaucaag gaagauggca uuucu                                            25

<210>  707
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  707
caacaucaag gaagauggca uuuc                                             24

<210>  708
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  708
caacaucaag gaagauggca uuu                                              23

<210>  709
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  709
caacaucaag gaagauggca uu                                               22

<210>  710
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  710
caacaucaag gaagauggca u                                                21

<210>  711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  711
caacaucaag gaagauggca                                                  20

<210>  712
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  712
caacaucaag gaagauggc                                                   19

<210>  713
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  713
caacaucaag gaagaugg                                                    18

<210>  714
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  714
caacaucaag gaagaug                                                     17

<210>  715
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  715
caacaucaag gaagau                                                      16

<210>  716
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  716
caacaucaag gaaga                                                       15

<210>  717
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  717
caacaucaag gaag                                                        14

<210>  718
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  718
aacaucaagg aagauggcau uucuag                                           26

<210>  719
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  719
aacaucaagg aagauggcau uucua                                            25

<210>  720
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  720
aacaucaagg aagauggcau uucu                                             24

<210>  721
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  721
aacaucaagg aagauggcau uuc                                              23

<210>  722
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  722
aacaucaagg aagauggcau uu                                               22

<210>  723
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  723
aacaucaagg aagauggcau u                                                21

<210>  724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  724
aacaucaagg aagauggcau                                                  20

<210>  725
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  725
aacaucaagg aagauggca                                                   19

<210>  726
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  726
aacaucaagg aagauggc                                                    18

<210>  727
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  727
aacaucaagg aagaugg                                                     17

<210>  728
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  728
aacaucaagg aagaug                                                      16

<210>  729
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  729
aacaucaagg aagau                                                       15

<210>  730
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  730
aacaucaagg aaga                                                        14

<210>  731
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  731
aacaucaagg aag                                                         13

<210>  732
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  732
acaucaagga agauggcauu ucuag                                            25

<210>  733
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  733
acaucaagga agauggcauu ucua                                             24

<210>  734
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  734
acaucaagga agauggcauu ucu                                              23

<210>  735
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  735
acaucaagga agauggcauu uc                                               22

<210>  736
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  736
acaucaagga agauggcauu u                                                21

<210>  737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  737
acaucaagga agauggcauu                                                  20

<210>  738
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  738
acaucaagga agauggcau                                                   19

<210>  739
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  739
acaucaagga agauggca                                                    18

<210>  740
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  740
acaucaagga agauggc                                                     17

<210>  741
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  741
acaucaagga agaugg                                                      16

<210>  742
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  742
acaucaagga agaug                                                       15

<210>  743
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  743
acaucaagga agau                                                        14

<210>  744
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  744
acaucaagga aga                                                         13

<210>  745
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  745
acaucaagga ag                                                          12

<210>  746
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  746
caucaaggaa gauggcauuu cuag                                             24

<210>  747
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  747
caucaaggaa gauggcauuu cua                                              23

<210>  748
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  748
caucaaggaa gauggcauuu cu                                               22

<210>  749
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  749
caucaaggaa gauggcauuu c                                                21

<210>  750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  750
caucaaggaa gauggcauuu                                                  20

<210>  751
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  751
caucaaggaa gauggcauu                                                   19

<210>  752
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  752
caucaaggaa gauggcau                                                    18

<210>  753
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  753
caucaaggaa gauggca                                                     17

<210>  754
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  754
caucaaggaa gauggc                                                      16

<210>  755
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  755
caucaaggaa gaugg                                                       15

<210>  756
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  756
caucaaggaa gaug                                                        14

<210>  757
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  757
caucaaggaa gau                                                         13

<210>  758
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  758
caucaaggaa ga                                                          12

<210>  759
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  759
caucaaggaa g                                                           11

<210>  760
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  760
aucaaggaag auggcauuuc uag                                              23

<210>  761
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  761
aucaaggaag auggcauuuc ua                                               22

<210>  762
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  762
aucaaggaag auggcauuuc u                                                21

<210>  763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  763
aucaaggaag auggcauuuc                                                  20

<210>  764
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  764
aucaaggaag auggcauuu                                                   19

<210>  765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  765
aucaaggaag auggcauu                                                    18

<210>  766
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  766
aucaaggaag auggcau                                                     17

<210>  767
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  767
aucaaggaag auggca                                                      16

<210>  768
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  768
aucaaggaag auggc                                                       15

<210>  769
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  769
aucaaggaag augg                                                        14

<210>  770
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  770
aucaaggaag aug                                                         13

<210>  771
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  771
aucaaggaag au                                                          12

<210>  772
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  772
aucaaggaag a                                                           11

<210>  773
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  773
aucaaggaag                                                             10

<210>  774
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  774
ggtaagttct gtccaagc                                                    18

<210>  775
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  775
gtaagttctg tccaagcc                                                    18

<210>  776
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  776
agtcggtaag ttctgtcc                                                    18

<210>  777
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  777
ctgtccaagc ccggttga                                                    18

<210>  778
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  778
taagttctgt ccaag                                                       15

<210>  779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  779
ttctgtccaa gcccggttga                                                  20

<210>  780
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  780
ttctgtccaa gcccggttg                                                   19

<210>  781
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  781
ttctgtccaa gcccggtt                                                    18

<210>  782
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  782
ttctgtccaa gcccggt                                                     17

<210>  783
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  783
ttctgtccaa gcccgg                                                      16

<210>  784
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  784
ttctgtccaa gcccg                                                       15

<210>  785
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  785
ttctgtccaa gccc                                                        14

<210>  786
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  786
ttctgtccaa gcc                                                         13

<210>  787
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  787
ttctgtccaa gc                                                          12

<210>  788
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  788
ttctgtccaa g                                                           11

<210>  789
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  789
ttctgtccaa                                                             10

<210>  790
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  790
ttctgtcca                                                              9

<210>  791
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  791
ttctgtcc                                                               8

<210>  792
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  792
tctgtccaag cccggttga                                                   19

<210>  793
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  793
tctgtccaag cccggttg                                                    18

<210>  794
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  794
tctgtccaag cccggtt                                                     17

<210>  795
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  795
tctgtccaag cccggt                                                      16

<210>  796
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  796
tctgtccaag cccgg                                                       15

<210>  797
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  797
tctgtccaag cccg                                                        14

<210>  798
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  798
tctgtccaag ccc                                                         13

<210>  799
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  799
tctgtccaag cc                                                          12

<210>  800
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  800
tctgtccaag c                                                           11

<210>  801
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  801
tctgtccaag                                                             10

<210>  802
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  802
tctgtccaa                                                              9

<210>  803
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  803
tctgtcca                                                               8

<210>  804
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  804
ctgtccaagc ccggttg                                                     17

<210>  805
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  805
ctgtccaagc ccggtt                                                      16

<210>  806
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  806
ctgtccaagc ccggt                                                       15

<210>  807
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  807
ctgtccaagc ccgg                                                        14

<210>  808
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  808
ctgtccaagc ccg                                                         13

<210>  809
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  809
ctgtccaagc cc                                                          12

<210>  810
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  810
ctgtccaagc c                                                           11

<210>  811
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  811
ctgtccaagc                                                             10

<210>  812
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  812
ctgtccaag                                                              9

<210>  813
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  813
ctgtccaa                                                               8

<210>  814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  814
gttctgtcca agcccggttg                                                  20

<210>  815
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  815
gttctgtcca agcccggtt                                                   19

<210>  816
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  816
gttctgtcca agcccggt                                                    18

<210>  817
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  817
gttctgtcca agcccgg                                                     17

<210>  818
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  818
gttctgtcca agcccg                                                      16

<210>  819
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  819
gttctgtcca agccc                                                       15

<210>  820
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  820
gttctgtcca agcc                                                        14

<210>  821
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  821
gttctgtcca agc                                                         13

<210>  822
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  822
gttctgtcca ag                                                          12

<210>  823
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  823
gttctgtcca a                                                           11

<210>  824
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  824
gttctgtcca                                                             10

<210>  825
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  825
gttctgtcc                                                              9

<210>  826
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  826
gttctgtc                                                               8

<210>  827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  827
agttctgtcc aagcccggtt                                                  20

<210>  828
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  828
agttctgtcc aagcccggt                                                   19

<210>  829
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  829
agttctgtcc aagcccgg                                                    18

<210>  830
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  830
agttctgtcc aagcccg                                                     17

<210>  831
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  831
agttctgtcc aagccc                                                      16

<210>  832
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  832
agttctgtcc aagcc                                                       15

<210>  833
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  833
agttctgtcc aagc                                                        14

<210>  834
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  834
agttctgtcc aag                                                         13

<210>  835
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  835
agttctgtcc aa                                                          12

<210>  836
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  836
agttctgtcc a                                                           11

<210>  837
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  837
agttctgtcc                                                             10

<210>  838
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  838
agttctgtc                                                              9

<210>  839
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  839
agttctgt                                                               8

<210>  840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  840
aagttctgtc caagcccggt                                                  20

<210>  841
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  841
aagttctgtc caagcccgg                                                   19

<210>  842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  842
aagttctgtc caagcccg                                                    18

<210>  843
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  843
aagttctgtc caagccc                                                     17

<210>  844
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  844
aagttctgtc caagcc                                                      16

<210>  845
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  845
aagttctgtc caagc                                                       15

<210>  846
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  846
aagttctgtc caag                                                        14

<210>  847
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  847
aagttctgtc caa                                                         13

<210>  848
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  848
aagttctgtc ca                                                          12

<210>  849
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  849
aagttctgtc c                                                           11

<210>  850
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  850
aagttctgtc                                                             10

<210>  851
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  851
aagttctgt                                                              9

<210>  852
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  852
aagttctg                                                               8

<210>  853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  853
taagttctgt ccaagcccgg                                                  20

<210>  854
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  854
taagttctgt ccaagcccg                                                   19

<210>  855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  855
taagttctgt ccaagccc                                                    18

<210>  856
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  856
taagttctgt ccaagcc                                                     17

<210>  857
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  857
taagttctgt ccaagc                                                      16

<210>  858
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  858
taagttctgt ccaa                                                        14

<210>  859
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  859
taagttctgt cca                                                         13

<210>  860
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  860
taagttctgt cc                                                          12

<210>  861
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  861
taagttctgt c                                                           11

<210>  862
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  862
taagttctgt                                                             10

<210>  863
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  863
taagttctg                                                              9

<210>  864
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  864
taagttct                                                               8

<210>  865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  865
gtaagttctg tccaagcccg                                                  20

<210>  866
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  866
gtaagttctg tccaagccc                                                   19

<210>  867
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  867
gtaagttctg tccaagc                                                     17

<210>  868
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  868
gtaagttctg tccaag                                                      16

<210>  869
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  869
gtaagttctg tccaa                                                       15

<210>  870
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  870
gtaagttctg tcca                                                        14

<210>  871
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  871
gtaagttctg tcc                                                         13

<210>  872
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  872
gtaagttctg tc                                                          12

<210>  873
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  873
gtaagttctg t                                                           11

<210>  874
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  874
gtaagttctg                                                             10

<210>  875
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  875
gtaagttct                                                              9

<210>  876
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  876
gtaagttc                                                               8

<210>  877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  877
ggtaagttct gtccaagccc                                                  20

<210>  878
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  878
ggtaagttct gtccaagcc                                                   19

<210>  879
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  879
ggtaagttct gtccaag                                                     17

<210>  880
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  880
ggtaagttct gtccaa                                                      16

<210>  881
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  881
ggtaagttct gtcca                                                       15

<210>  882
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  882
ggtaagttct gtcc                                                        14

<210>  883
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  883
ggtaagttct gtc                                                         13

<210>  884
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  884
ggtaagttct gt                                                          12

<210>  885
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  885
ggtaagttct g                                                           11

<210>  886
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  886
ggtaagttct                                                             10

<210>  887
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  887
ggtaagttc                                                              9

<210>  888
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  888
ggtaagtt                                                               8

<210>  889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  889
cggtaagttc tgtccaagcc                                                  20

<210>  890
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  890
cggtaagttc tgtccaagc                                                   19

<210>  891
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  891
cggtaagttc tgtccaag                                                    18

<210>  892
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  892
cggtaagttc tgtccaa                                                     17

<210>  893
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  893
cggtaagttc tgtcca                                                      16

<210>  894
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  894
cggtaagttc tgtcc                                                       15

<210>  895
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  895
cggtaagttc tgtc                                                        14

<210>  896
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  896
cggtaagttc tgt                                                         13

<210>  897
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  897
cggtaagttc tg                                                          12

<210>  898
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  898
cggtaagttc t                                                           11

<210>  899
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  899
cggtaagttc                                                             10

<210>  900
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  900
cggtaagtt                                                              9

<210>  901
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  901
cggtaagt                                                               8

<210>  902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  902
tcggtaagtt ctgtccaagc                                                  20

<210>  903
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  903
tcggtaagtt ctgtccaag                                                   19

<210>  904
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  904
tcggtaagtt ctgtccaa                                                    18

<210>  905
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  905
tcggtaagtt ctgtcca                                                     17

<210>  906
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  906
tcggtaagtt ctgtcc                                                      16

<210>  907
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  907
tcggtaagtt ctgtc                                                       15

<210>  908
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  908
tcggtaagtt ctgt                                                        14

<210>  909
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  909
tcggtaagtt ctg                                                         13

<210>  910
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  910
tcggtaagtt ct                                                          12

<210>  911
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  911
tcggtaagtt c                                                           11

<210>  912
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  912
tcggtaagtt                                                             10

<210>  913
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  913
tcggtaagt                                                              9

<210>  914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  914
gtcggtaagt tctgtccaag                                                  20

<210>  915
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  915
gtcggtaagt tctgtccaa                                                   19

<210>  916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  916
gtcggtaagt tctgtcca                                                    18

<210>  917
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  917
gtcggtaagt tctgtcc                                                     17

<210>  918
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  918
gtcggtaagt tctgtc                                                      16

<210>  919
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  919
gtcggtaagt tctgt                                                       15

<210>  920
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  920
gtcggtaagt tctg                                                        14

<210>  921
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  921
gtcggtaagt tct                                                         13

<210>  922
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  922
gtcggtaagt tc                                                          12

<210>  923
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  923
gtcggtaagt t                                                           11

<210>  924
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  924
gtcggtaagt                                                             10

<210>  925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  925
agtcggtaag ttctgtccaa                                                  20

<210>  926
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  926
agtcggtaag ttctgtcca                                                   19

<210>  927
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  927
agtcggtaag ttctgtc                                                     17

<210>  928
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  928
agtcggtaag ttctgt                                                      16

<210>  929
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  929
agtcggtaag ttctg                                                       15

<210>  930
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  930
agtcggtaag ttct                                                        14

<210>  931
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  931
agtcggtaag ttc                                                         13

<210>  932
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  932
agtcggtaag tt                                                          12

<210>  933
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  933
agtcggtaag t                                                           11

<210>  934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  934
cagtcggtaa gttctgtcca                                                  20

<210>  935
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  935
cagtcggtaa gttctgtcc                                                   19

<210>  936
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  936
cagtcggtaa gttctgtc                                                    18

<210>  937
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  937
cagtcggtaa gttctgt                                                     17

<210>  938
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  938
cagtcggtaa gttctg                                                      16

<210>  939
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  939
cagtcggtaa gttct                                                       15

<210>  940
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  940
cagtcggtaa gttc                                                        14

<210>  941
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  941
cagtcggtaa gtt                                                         13

<210>  942
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  942
cagtcggtaa gt                                                          12

<210>  943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  943
ccagtcggta agttctgtcc                                                  20

<210>  944
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  944
ccagtcggta agttctgtc                                                   19

<210>  945
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  945
ccagtcggta agttctgt                                                    18

<210>  946
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  946
ccagtcggta agttctg                                                     17

<210>  947
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  947
ccagtcggta agttct                                                      16

<210>  948
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  948
ccagtcggta agttc                                                       15

<210>  949
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  949
ccagtcggta agtt                                                        14

<210>  950
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  950
ccagtcggta agt                                                         13

<210>  951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  951
gccagtcggt aagttctgtc                                                  20

<210>  952
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  952
gccagtcggt aagttctgt                                                   19

<210>  953
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  953
gccagtcggt aagttctg                                                    18

<210>  954
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  954
gccagtcggt aagttct                                                     17

<210>  955
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  955
gccagtcggt aagttc                                                      16

<210>  956
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  956
gccagtcggt aagtt                                                       15

<210>  957
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  957
gccagtcggt aagt                                                        14

<210>  958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  958
tcaaggaaga tggcatttct                                                  20

<210>  959
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  959
tcaaggaaga tggcatttct ag                                               22

<210>  960
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  960
tcaaggaaga tggcat                                                      16

<210>  961
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  961
gaagatggca tttct                                                       15

<210>  962
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  962
tcaaggaaga tggcatttct a                                                21

<210>  963
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  963
tcaaggaaga tggcatttc                                                   19

<210>  964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  964
tcaaggaaga tggcattt                                                    18

<210>  965
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  965
tcaaggaaga tggcatt                                                     17

<210>  966
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  966
tcaaggaaga tggca                                                       15

<210>  967
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  967
tcaaggaaga tggc                                                        14

<210>  968
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  968
tcaaggaaga tgg                                                         13

<210>  969
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  969
tcaaggaaga tg                                                          12

<210>  970
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  970
tcaaggaaga t                                                           11

<210>  971
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  971
tcaaggaaga                                                             10

<210>  972
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  972
tcaaggaag                                                              9

<210>  973
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  973
caaggaagat ggcatttcta g                                                21

<210>  974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  974
caaggaagat ggcatttcta                                                  20

<210>  975
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  975
caaggaagat ggcatttct                                                   19

<210>  976
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  976
caaggaagat ggcatttc                                                    18

<210>  977
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  977
caaggaagat ggcattt                                                     17

<210>  978
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  978
caaggaagat ggcatt                                                      16

<210>  979
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  979
caaggaagat ggcat                                                       15

<210>  980
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  980
caaggaagat ggca                                                        14

<210>  981
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  981
caaggaagat ggc                                                         13

<210>  982
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  982
caaggaagat gg                                                          12

<210>  983
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  983
caaggaagat g                                                           11

<210>  984
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  984
caaggaagat                                                             10

<210>  985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  985
aaggaagatg gcatttctag                                                  20

<210>  986
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  986
aaggaagatg gcatttcta                                                   19

<210>  987
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  987
aaggaagatg gcatttct                                                    18

<210>  988
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  988
aaggaagatg gcatttc                                                     17

<210>  989
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  989
aaggaagatg gcattt                                                      16

<210>  990
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  990
aaggaagatg gcatt                                                       15

<210>  991
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  991
aaggaagatg gcat                                                        14

<210>  992
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  992
aaggaagatg gca                                                         13

<210>  993
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  993
aaggaagatg gc                                                          12

<210>  994
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  994
aaggaagatg g                                                           11

<210>  995
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  995
aaggaagatg                                                             10

<210>  996
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  996
aaggaagat                                                              9

<210>  997
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  997
aggaagatgg catttctag                                                   19

<210>  998
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  998
aggaagatgg catttcta                                                    18

<210>  999
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  999
aggaagatgg catttct                                                     17

<210>  1000
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1000
aggaagatgg catttc                                                      16

<210>  1001
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1001
aggaagatgg cattt                                                       15

<210>  1002
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1002
aggaagatgg catt                                                        14

<210>  1003
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1003
aggaagatgg cat                                                         13

<210>  1004
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1004
aggaagatgg ca                                                          12

<210>  1005
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1005
aggaagatgg                                                             10

<210>  1006
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1006
aggaagatg                                                              9

<210>  1007
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1007
aggaagat                                                               8

<210>  1008
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1008
ggaagatggc atttctag                                                    18

<210>  1009
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1009
ggaagatggc atttcta                                                     17

<210>  1010
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1010
ggaagatggc atttct                                                      16

<210>  1011
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1011
ggaagatggc atttc                                                       15

<210>  1012
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1012
ggaagatggc attt                                                        14

<210>  1013
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1013
ggaagatggc att                                                         13

<210>  1014
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1014
ggaagatggc at                                                          12

<210>  1015
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1015
ggaagatggc a                                                           11

<210>  1016
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1016
ggaagatggc                                                             10

<210>  1017
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1017
ggaagatg                                                               8

<210>  1018
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1018
gaagatggca tttctag                                                     17

<210>  1019
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1019
gaagatggca tttcta                                                      16

<210>  1020
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1020
gaagatggca tttc                                                        14

<210>  1021
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1021
gaagatggca ttt                                                         13

<210>  1022
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1022
gaagatggca tt                                                          12

<210>  1023
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1023
gaagatggca t                                                           11

<210>  1024
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1024
gaagatggca                                                             10

<210>  1025
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1025
gaagatggc                                                              9

<210>  1026
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1026
gaagatgg                                                               8

<210>  1027
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1027
aagatggcat ttctag                                                      16

<210>  1028
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1028
aagatggcat ttcta                                                       15

<210>  1029
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1029
aagatggcat ttct                                                        14

<210>  1030
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1030
aagatggcat ttc                                                         13

<210>  1031
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1031
aagatggcat tt                                                          12

<210>  1032
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1032
aagatggcat t                                                           11

<210>  1033
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1033
aagatggcat                                                             10

<210>  1034
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1034
aagatggca                                                              9

<210>  1035
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1035
aagatggc                                                               8

<210>  1036
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1036
agatggcatt tctag                                                       15

<210>  1037
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1037
agatggcatt tcta                                                        14

<210>  1038
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1038
agatggcatt tct                                                         13

<210>  1039
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1039
agatggcatt tc                                                          12

<210>  1040
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1040
agatggcatt t                                                           11

<210>  1041
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1041
agatggcatt                                                             10

<210>  1042
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1042
agatggcat                                                              9

<210>  1043
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1043
agatggca                                                               8

<210>  1044
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1044
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  1045
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1045
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  1046
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1046
ctccaacatc aaggaagatg gcatttct                                         28

<210>  1047
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1047
ctccaacatc aaggaagatg gcatttc                                          27

<210>  1048
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1048
ctccaacatc aaggaagatg gcattt                                           26

<210>  1049
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1049
ctccaacatc aaggaagatg gcatt                                            25

<210>  1050
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1050
ctccaacatc aaggaagatg gcat                                             24

<210>  1051
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1051
ctccaacatc aaggaagatg gca                                              23

<210>  1052
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1052
ctccaacatc aaggaagatg gc                                               22

<210>  1053
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1053
ctccaacatc aaggaagatg g                                                21

<210>  1054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1054
ctccaacatc aaggaagatg                                                  20

<210>  1055
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1055
ctccaacatc aaggaagat                                                   19

<210>  1056
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1056
ctccaacatc aaggaaga                                                    18

<210>  1057
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1057
ctccaacatc aaggaag                                                     17

<210>  1058
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1058
tccaacatca aggaagatgg catttctag                                        29

<210>  1059
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1059
tccaacatca aggaagatgg catttcta                                         28

<210>  1060
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1060
tccaacatca aggaagatgg catttct                                          27

<210>  1061
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1061
tccaacatca aggaagatgg catttc                                           26

<210>  1062
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1062
tccaacatca aggaagatgg cattt                                            25

<210>  1063
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1063
tccaacatca aggaagatgg catt                                             24

<210>  1064
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1064
tccaacatca aggaagatgg cat                                              23

<210>  1065
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1065
tccaacatca aggaagatgg ca                                               22

<210>  1066
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1066
tccaacatca aggaagatgg c                                                21

<210>  1067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1067
tccaacatca aggaagatgg                                                  20

<210>  1068
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1068
tccaacatca aggaagatg                                                   19

<210>  1069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1069
tccaacatca aggaagat                                                    18

<210>  1070
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1070
tccaacatca aggaaga                                                     17

<210>  1071
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1071
tccaacatca aggaag                                                      16

<210>  1072
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1072
ccaacatcaa ggaagatggc atttctag                                         28

<210>  1073
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1073
ccaacatcaa ggaagatggc atttcta                                          27

<210>  1074
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1074
ccaacatcaa ggaagatggc atttct                                           26

<210>  1075
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1075
ccaacatcaa ggaagatggc atttc                                            25

<210>  1076
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1076
ccaacatcaa ggaagatggc attt                                             24

<210>  1077
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1077
ccaacatcaa ggaagatggc att                                              23

<210>  1078
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1078
ccaacatcaa ggaagatggc at                                               22

<210>  1079
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1079
ccaacatcaa ggaagatggc a                                                21

<210>  1080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1080
ccaacatcaa ggaagatggc                                                  20

<210>  1081
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1081
ccaacatcaa ggaagatgg                                                   19

<210>  1082
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1082
ccaacatcaa ggaagatg                                                    18

<210>  1083
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1083
ccaacatcaa ggaagat                                                     17

<210>  1084
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1084
ccaacatcaa ggaaga                                                      16

<210>  1085
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1085
ccaacatcaa ggaag                                                       15

<210>  1086
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1086
caacatcaag gaagatggca tttctag                                          27

<210>  1087
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1087
caacatcaag gaagatggca tttcta                                           26

<210>  1088
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1088
caacatcaag gaagatggca tttct                                            25

<210>  1089
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1089
caacatcaag gaagatggca tttc                                             24

<210>  1090
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1090
caacatcaag gaagatggca ttt                                              23

<210>  1091
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1091
caacatcaag gaagatggca tt                                               22

<210>  1092
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1092
caacatcaag gaagatggca t                                                21

<210>  1093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1093
caacatcaag gaagatggca                                                  20

<210>  1094
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1094
caacatcaag gaagatggc                                                   19

<210>  1095
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1095
caacatcaag gaagatgg                                                    18

<210>  1096
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1096
caacatcaag gaagatg                                                     17

<210>  1097
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1097
caacatcaag gaagat                                                      16

<210>  1098
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1098
caacatcaag gaaga                                                       15

<210>  1099
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1099
caacatcaag gaag                                                        14

<210>  1100
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1100
aacatcaagg aagatggcat ttctag                                           26

<210>  1101
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1101
aacatcaagg aagatggcat ttcta                                            25

<210>  1102
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1102
aacatcaagg aagatggcat ttct                                             24

<210>  1103
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1103
aacatcaagg aagatggcat ttc                                              23

<210>  1104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1104
aacatcaagg aagatggcat tt                                               22

<210>  1105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1105
aacatcaagg aagatggcat t                                                21

<210>  1106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1106
aacatcaagg aagatggcat                                                  20

<210>  1107
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1107
aacatcaagg aagatggca                                                   19

<210>  1108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1108
aacatcaagg aagatggc                                                    18

<210>  1109
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1109
aacatcaagg aagatgg                                                     17

<210>  1110
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1110
aacatcaagg aagatg                                                      16

<210>  1111
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1111
aacatcaagg aagat                                                       15

<210>  1112
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1112
aacatcaagg aaga                                                        14

<210>  1113
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1113
aacatcaagg aag                                                         13

<210>  1114
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1114
acatcaagga agatggcatt tctag                                            25

<210>  1115
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1115
acatcaagga agatggcatt tcta                                             24

<210>  1116
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1116
acatcaagga agatggcatt tct                                              23

<210>  1117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1117
acatcaagga agatggcatt tc                                               22

<210>  1118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1118
acatcaagga agatggcatt t                                                21

<210>  1119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1119
acatcaagga agatggcatt                                                  20

<210>  1120
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1120
acatcaagga agatggcat                                                   19

<210>  1121
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1121
acatcaagga agatggca                                                    18

<210>  1122
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1122
acatcaagga agatggc                                                     17

<210>  1123
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1123
acatcaagga agatgg                                                      16

<210>  1124
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1124
acatcaagga agatg                                                       15

<210>  1125
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1125
acatcaagga agat                                                        14

<210>  1126
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1126
acatcaagga aga                                                         13

<210>  1127
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1127
acatcaagga ag                                                          12

<210>  1128
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1128
catcaaggaa gatggcattt ctag                                             24

<210>  1129
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1129
catcaaggaa gatggcattt cta                                              23

<210>  1130
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1130
catcaaggaa gatggcattt ct                                               22

<210>  1131
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1131
catcaaggaa gatggcattt c                                                21

<210>  1132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1132
catcaaggaa gatggcattt                                                  20

<210>  1133
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1133
catcaaggaa gatggcatt                                                   19

<210>  1134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1134
catcaaggaa gatggcat                                                    18

<210>  1135
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1135
catcaaggaa gatggca                                                     17

<210>  1136
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1136
catcaaggaa gatggc                                                      16

<210>  1137
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1137
catcaaggaa gatgg                                                       15

<210>  1138
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1138
catcaaggaa gatg                                                        14

<210>  1139
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1139
catcaaggaa gat                                                         13

<210>  1140
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1140
catcaaggaa ga                                                          12

<210>  1141
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1141
catcaaggaa g                                                           11

<210>  1142
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1142
atcaaggaag atggcatttc tag                                              23

<210>  1143
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1143
atcaaggaag atggcatttc ta                                               22

<210>  1144
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1144
atcaaggaag atggcatttc t                                                21

<210>  1145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1145
atcaaggaag atggcatttc                                                  20

<210>  1146
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1146
atcaaggaag atggcattt                                                   19

<210>  1147
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1147
atcaaggaag atggcatt                                                    18

<210>  1148
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1148
atcaaggaag atggcat                                                     17

<210>  1149
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1149
atcaaggaag atggca                                                      16

<210>  1150
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1150
atcaaggaag atggc                                                       15

<210>  1151
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1151
atcaaggaag atgg                                                        14

<210>  1152
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1152
atcaaggaag atg                                                         13

<210>  1153
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1153
atcaaggaag at                                                          12

<210>  1154
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1154
atcaaggaag a                                                           11

<210>  1155
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  1155
atcaaggaag                                                             10

<210>  1156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1156
ggtaagttct gtccaagc                                                    18

<210>  1157
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  1157
gtaagttctg tccaagcc                                                    18

<210>  1158
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  1158
agtcggtaag ttctgtcc                                                    18

<210>  1159
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1159
ctgtccaagc ccggttga                                                    18

<210>  1160
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  1160
taagttctgt ccaag                                                       15

<210>  1161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1161
ttctgtccaa gcccggttga                                                  20

<210>  1162
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1162
ttctgtccaa gcccggttg                                                   19

<210>  1163
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1163
ttctgtccaa gcccggtt                                                    18

<210>  1164
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1164
ttctgtccaa gcccggt                                                     17

<210>  1165
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1165
ttctgtccaa gcccgg                                                      16

<210>  1166
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1166
ttctgtccaa gcccg                                                       15

<210>  1167
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  1167
ttctgtccaa gccc                                                        14

<210>  1168
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  1168
ttctgtccaa gcc                                                         13

<210>  1169
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1169
ttctgtccaa gc                                                          12

<210>  1170
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  1170
ttctgtccaa g                                                           11

<210>  1171
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  1171
ttctgtccaa                                                             10

<210>  1172
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  1172
ttctgtcca                                                              9

<210>  1173
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  1173
ttctgtcc                                                               8

<210>  1174
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1174
tctgtccaag cccggttga                                                   19

<210>  1175
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1175
tctgtccaag cccggttg                                                    18

<210>  1176
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1176
tctgtccaag cccggtt                                                     17

<210>  1177
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1177
tctgtccaag cccggt                                                      16

<210>  1178
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1178
tctgtccaag cccgg                                                       15

<210>  1179
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1179
tctgtccaag cccg                                                        14

<210>  1180
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  1180
tctgtccaag ccc                                                         13

<210>  1181
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  1181
tctgtccaag cc                                                          12

<210>  1182
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1182
tctgtccaag c                                                           11

<210>  1183
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  1183
tctgtccaag                                                             10

<210>  1184
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  1184
tctgtccaa                                                              9

<210>  1185
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  1185
tctgtcca                                                               8

<210>  1186
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1186
ctgtccaagc ccggttg                                                     17

<210>  1187
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1187
ctgtccaagc ccggtt                                                      16

<210>  1188
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1188
ctgtccaagc ccggt                                                       15

<210>  1189
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1189
ctgtccaagc ccgg                                                        14

<210>  1190
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1190
ctgtccaagc ccg                                                         13

<210>  1191
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<400>  1191
ctgtccaagc cc                                                          12

<210>  1192
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  1192
ctgtccaagc c                                                           11

<210>  1193
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1193
ctgtccaagc                                                             10

<210>  1194
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<400>  1194
ctgtccaag                                                              9

<210>  1195
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<400>  1195
ctgtccaa                                                               8

<210>  1196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  1196
gttctgtcca agcccggttg                                                  20

<210>  1197
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  1197
gttctgtcca agcccggtt                                                   19

<210>  1198
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  1198
gttctgtcca agcccggt                                                    18

<210>  1199
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  1199
gttctgtcca agcccgg                                                     17

<210>  1200
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  1200
gttctgtcca agcccg                                                      16

<210>  1201
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  1201
gttctgtcca agccc                                                       15

<210>  1202
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  1202
gttctgtcca agcc                                                        14

<210>  1203
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1203
gttctgtcca agc                                                         13

<210>  1204
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  1204
gttctgtcca ag                                                          12

<210>  1205
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  1205
gttctgtcca a                                                           11

<210>  1206
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  1206
gttctgtcca                                                             10

<210>  1207
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  1207
gttctgtcc                                                              9

<210>  1208
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1208
gttctgtc                                                               8

<210>  1209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  1209
agttctgtcc aagcccggtt                                                  20

<210>  1210
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  1210
agttctgtcc aagcccggt                                                   19

<210>  1211
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  1211
agttctgtcc aagcccgg                                                    18

<210>  1212
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  1212
agttctgtcc aagcccg                                                     17

<210>  1213
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  1213
agttctgtcc aagccc                                                      16

<210>  1214
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  1214
agttctgtcc aagcc                                                       15

<210>  1215
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1215
agttctgtcc aagc                                                        14

<210>  1216
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  1216
agttctgtcc aag                                                         13

<210>  1217
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  1217
agttctgtcc aa                                                          12

<210>  1218
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  1218
agttctgtcc a                                                           11

<210>  1219
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  1219
agttctgtcc                                                             10

<210>  1220
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1220
agttctgtc                                                              9

<210>  1221
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1221
agttctgt                                                               8

<210>  1222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  1222
aagttctgtc caagcccggt                                                  20

<210>  1223
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  1223
aagttctgtc caagcccgg                                                   19

<210>  1224
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  1224
aagttctgtc caagcccg                                                    18

<210>  1225
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  1225
aagttctgtc caagccc                                                     17

<210>  1226
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  1226
aagttctgtc caagcc                                                      16

<210>  1227
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1227
aagttctgtc caagc                                                       15

<210>  1228
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  1228
aagttctgtc caag                                                        14

<210>  1229
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  1229
aagttctgtc caa                                                         13

<210>  1230
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  1230
aagttctgtc ca                                                          12

<210>  1231
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  1231
aagttctgtc c                                                           11

<210>  1232
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1232
aagttctgtc                                                             10

<210>  1233
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1233
aagttctgt                                                              9

<210>  1234
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1234
aagttctg                                                               8

<210>  1235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  1235
taagttctgt ccaagcccgg                                                  20

<210>  1236
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  1236
taagttctgt ccaagcccg                                                   19

<210>  1237
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  1237
taagttctgt ccaagccc                                                    18

<210>  1238
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  1238
taagttctgt ccaagcc                                                     17

<210>  1239
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1239
taagttctgt ccaagc                                                      16

<210>  1240
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  1240
taagttctgt ccaa                                                        14

<210>  1241
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  1241
taagttctgt cca                                                         13

<210>  1242
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  1242
taagttctgt cc                                                          12

<210>  1243
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1243
taagttctgt c                                                           11

<210>  1244
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1244
taagttctgt                                                             10

<210>  1245
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1245
taagttctg                                                              9

<210>  1246
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1246
taagttct                                                               8

<210>  1247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  1247
gtaagttctg tccaagcccg                                                  20

<210>  1248
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  1248
gtaagttctg tccaagccc                                                   19

<210>  1249
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1249
gtaagttctg tccaagc                                                     17

<210>  1250
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  1250
gtaagttctg tccaag                                                      16

<210>  1251
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  1251
gtaagttctg tccaa                                                       15

<210>  1252
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  1252
gtaagttctg tcca                                                        14

<210>  1253
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  1253
gtaagttctg tcc                                                         13

<210>  1254
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1254
gtaagttctg tc                                                          12

<210>  1255
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1255
gtaagttctg t                                                           11

<210>  1256
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1256
gtaagttctg                                                             10

<210>  1257
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1257
gtaagttct                                                              9

<210>  1258
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1258
gtaagttc                                                               8

<210>  1259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  1259
ggtaagttct gtccaagccc                                                  20

<210>  1260
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  1260
ggtaagttct gtccaagcc                                                   19

<210>  1261
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  1261
ggtaagttct gtccaag                                                     17

<210>  1262
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  1262
ggtaagttct gtccaa                                                      16

<210>  1263
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  1263
ggtaagttct gtcca                                                       15

<210>  1264
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  1264
ggtaagttct gtcc                                                        14

<210>  1265
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1265
ggtaagttct gtc                                                         13

<210>  1266
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1266
ggtaagttct gt                                                          12

<210>  1267
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1267
ggtaagttct g                                                           11

<210>  1268
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1268
ggtaagttct                                                             10

<210>  1269
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1269
ggtaagttc                                                              9

<210>  1270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<400>  1270
cggtaagttc tgtccaagcc                                                  20

<210>  1271
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1271
cggtaagttc tgtccaagc                                                   19

<210>  1272
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  1272
cggtaagttc tgtccaag                                                    18

<210>  1273
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  1273
cggtaagttc tgtccaa                                                     17

<210>  1274
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  1274
cggtaagttc tgtcca                                                      16

<210>  1275
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  1275
cggtaagttc tgtcc                                                       15

<210>  1276
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1276
cggtaagttc tgtc                                                        14

<210>  1277
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1277
cggtaagttc tgt                                                         13

<210>  1278
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1278
cggtaagttc tg                                                          12

<210>  1279
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1279
cggtaagttc t                                                           11

<210>  1280
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1280
cggtaagttc                                                             10

<210>  1281
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  1281
cggtaagtt                                                              9

<210>  1282
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  1282
cggtaagt                                                               8

<210>  1283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1283
tcggtaagtt ctgtccaagc                                                  20

<210>  1284
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  1284
tcggtaagtt ctgtccaag                                                   19

<210>  1285
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  1285
tcggtaagtt ctgtccaa                                                    18

<210>  1286
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  1286
tcggtaagtt ctgtcca                                                     17

<210>  1287
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  1287
tcggtaagtt ctgtcc                                                      16

<210>  1288
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1288
tcggtaagtt ctgtc                                                       15

<210>  1289
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1289
tcggtaagtt ctgt                                                        14

<210>  1290
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1290
tcggtaagtt ctg                                                         13

<210>  1291
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1291
tcggtaagtt ct                                                          12

<210>  1292
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1292
tcggtaagtt c                                                           11

<210>  1293
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1293
tcggtaagtt                                                             10

<210>  1294
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1294
tcggtaagt                                                              9

<210>  1295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  1295
gtcggtaagt tctgtccaag                                                  20

<210>  1296
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  1296
gtcggtaagt tctgtccaa                                                   19

<210>  1297
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  1297
gtcggtaagt tctgtcca                                                    18

<210>  1298
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  1298
gtcggtaagt tctgtcc                                                     17

<210>  1299
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1299
gtcggtaagt tctgtc                                                      16

<210>  1300
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1300
gtcggtaagt tctgt                                                       15

<210>  1301
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1301
gtcggtaagt tctg                                                        14

<210>  1302
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1302
gtcggtaagt tct                                                         13

<210>  1303
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1303
gtcggtaagt tc                                                          12

<210>  1304
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1304
gtcggtaagt t                                                           11

<210>  1305
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1305
gtcggtaagt                                                             10

<210>  1306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  1306
agtcggtaag ttctgtccaa                                                  20

<210>  1307
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  1307
agtcggtaag ttctgtcca                                                   19

<210>  1308
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1308
agtcggtaag ttctgtc                                                     17

<210>  1309
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1309
agtcggtaag ttctgt                                                      16

<210>  1310
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1310
agtcggtaag ttctg                                                       15

<210>  1311
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1311
agtcggtaag ttct                                                        14

<210>  1312
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1312
agtcggtaag ttc                                                         13

<210>  1313
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1313
agtcggtaag tt                                                          12

<210>  1314
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1314
agtcggtaag t                                                           11

<210>  1315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  1315
cagtcggtaa gttctgtcca                                                  20

<210>  1316
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  1316
cagtcggtaa gttctgtcc                                                   19

<210>  1317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1317
cagtcggtaa gttctgtc                                                    18

<210>  1318
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1318
cagtcggtaa gttctgt                                                     17

<210>  1319
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1319
cagtcggtaa gttctg                                                      16

<210>  1320
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1320
cagtcggtaa gttct                                                       15

<210>  1321
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1321
cagtcggtaa gttc                                                        14

<210>  1322
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1322
cagtcggtaa gtt                                                         13

<210>  1323
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1323
cagtcggtaa gt                                                          12

<210>  1324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<400>  1324
ccagtcggta agttctgtcc                                                  20

<210>  1325
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1325
ccagtcggta agttctgtc                                                   19

<210>  1326
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1326
ccagtcggta agttctgt                                                    18

<210>  1327
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1327
ccagtcggta agttctg                                                     17

<210>  1328
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1328
ccagtcggta agttct                                                      16

<210>  1329
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1329
ccagtcggta agttc                                                       15

<210>  1330
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1330
ccagtcggta agtt                                                        14

<210>  1331
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1331
ccagtcggta agt                                                         13

<210>  1332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1332
gccagtcggt aagttctgtc                                                  20

<210>  1333
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1333
gccagtcggt aagttctgt                                                   19

<210>  1334
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1334
gccagtcggt aagttctg                                                    18

<210>  1335
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1335
gccagtcggt aagttct                                                     17

<210>  1336
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1336
gccagtcggt aagttc                                                      16

<210>  1337
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1337
gccagtcggt aagtt                                                       15

<210>  1338
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1338
gccagtcggt aagt                                                        14

<210>  1339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1339
tcaaggaaga tggcatttct                                                  20

<210>  1340
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1340
tcaaggaaga tggcatttct ag                                               22

<210>  1341
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1341
tcaaggaaga tggcat                                                      16

<210>  1342
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1342
gaagatggca tttct                                                       15

<210>  1343
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1343
tcaaggaaga tggcatttct a                                                21

<210>  1344
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1344
tcaaggaaga tggcatttc                                                   19

<210>  1345
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1345
tcaaggaaga tggcattt                                                    18

<210>  1346
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1346
tcaaggaaga tggcatt                                                     17

<210>  1347
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1347
tcaaggaaga tggca                                                       15

<210>  1348
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1348
tcaaggaaga tggc                                                        14

<210>  1349
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1349
tcaaggaaga tgg                                                         13

<210>  1350
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1350
tcaaggaaga tg                                                          12

<210>  1351
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1351
tcaaggaaga t                                                           11

<210>  1352
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1352
tcaaggaaga                                                             10

<210>  1353
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  1353
tcaaggaag                                                              9

<210>  1354
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1354
caaggaagat ggcatttcta g                                                21

<210>  1355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1355
caaggaagat ggcatttcta                                                  20

<210>  1356
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1356
caaggaagat ggcatttct                                                   19

<210>  1357
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1357
caaggaagat ggcatttc                                                    18

<210>  1358
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1358
caaggaagat ggcattt                                                     17

<210>  1359
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1359
caaggaagat ggcatt                                                      16

<210>  1360
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1360
caaggaagat ggcat                                                       15

<210>  1361
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1361
caaggaagat ggca                                                        14

<210>  1362
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1362
caaggaagat ggc                                                         13

<210>  1363
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  1363
caaggaagat gg                                                          12

<210>  1364
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  1364
caaggaagat g                                                           11

<210>  1365
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<400>  1365
caaggaagat                                                             10

<210>  1366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1366
aaggaagatg gcatttctag                                                  20

<210>  1367
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1367
aaggaagatg gcatttcta                                                   19

<210>  1368
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1368
aaggaagatg gcatttct                                                    18

<210>  1369
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1369
aaggaagatg gcatttc                                                     17

<210>  1370
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1370
aaggaagatg gcattt                                                      16

<210>  1371
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1371
aaggaagatg gcatt                                                       15

<210>  1372
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1372
aaggaagatg gcat                                                        14

<210>  1373
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1373
aaggaagatg gca                                                         13

<210>  1374
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1374
aaggaagatg gc                                                          12

<210>  1375
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1375
aggaagatgg catttctag                                                   19

<210>  1376
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1376
aggaagatgg catttcta                                                    18

<210>  1377
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1377
aggaagatgg catttct                                                     17

<210>  1378
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1378
aggaagatgg catttc                                                      16

<210>  1379
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1379
aggaagatgg cattt                                                       15

<210>  1380
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1380
aggaagatgg catt                                                        14

<210>  1381
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1381
aggaagatgg cat                                                         13

<210>  1382
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  1382
aggaagatgg ca                                                          12

<210>  1383
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1383
ggaagatggc atttctag                                                    18

<210>  1384
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1384
ggaagatggc atttcta                                                     17

<210>  1385
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1385
ggaagatggc atttct                                                      16

<210>  1386
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1386
ggaagatggc atttc                                                       15

<210>  1387
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1387
ggaagatggc attt                                                        14

<210>  1388
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1388
ggaagatggc att                                                         13

<210>  1389
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1389
ggaagatggc at                                                          12

<210>  1390
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1390
ggaagatggc a                                                           11

<210>  1391
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1391
ggaagatggc                                                             10

<210>  1392
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1392
gaagatggca tttctag                                                     17

<210>  1393
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1393
gaagatggca tttcta                                                      16

<210>  1394
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  1394
gaagatggca tttc                                                        14

<210>  1395
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1395
gaagatggca ttt                                                         13

<210>  1396
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1396
gaagatggca tt                                                          12

<210>  1397
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1397
gaagatggca t                                                           11

<210>  1398
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1398
gaagatggca                                                             10

<210>  1399
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1399
gaagatggc                                                              9

<210>  1400
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1400
aagatggcat ttctag                                                      16

<210>  1401
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1401
aagatggcat ttcta                                                       15

<210>  1402
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1402
aagatggcat ttct                                                        14

<210>  1403
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  1403
aagatggcat ttc                                                         13

<210>  1404
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1404
aagatggcat tt                                                          12

<210>  1405
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1405
aagatggcat t                                                           11

<210>  1406
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1406
aagatggcat                                                             10

<210>  1407
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1407
aagatggca                                                              9

<210>  1408
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1408
aagatggc                                                               8

<210>  1409
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1409
agatggcatt tctag                                                       15

<210>  1410
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1410
agatggcatt tcta                                                        14

<210>  1411
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1411
agatggcatt tct                                                         13

<210>  1412
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  1412
agatggcatt tc                                                          12

<210>  1413
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1413
agatggcatt t                                                           11

<210>  1414
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1414
agatggcatt                                                             10

<210>  1415
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1415
agatggcat                                                              9

<210>  1416
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1416
agatggca                                                               8

<210>  1417
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  1417
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  1418
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  1418
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  1419
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  1419
ctccaacatc aaggaagatg gcatttct                                         28

<210>  1420
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<400>  1420
ctccaacatc aaggaagatg gcatttc                                          27

<210>  1421
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1421
ctccaacatc aaggaagatg gcattt                                           26

<210>  1422
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1422
ctccaacatc aaggaagatg gcatt                                            25

<210>  1423
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1423
ctccaacatc aaggaagatg gcat                                             24

<210>  1424
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1424
ctccaacatc aaggaagatg gca                                              23

<210>  1425
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1425
ctccaacatc aaggaagatg gc                                               22

<210>  1426
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1426
ctccaacatc aaggaagatg g                                                21

<210>  1427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1427
ctccaacatc aaggaagatg                                                  20

<210>  1428
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1428
ctccaacatc aaggaagat                                                   19

<210>  1429
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1429
ctccaacatc aaggaaga                                                    18

<210>  1430
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  1430
ctccaacatc aaggaag                                                     17

<210>  1431
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  1431
tccaacatca aggaagatgg catttctag                                        29

<210>  1432
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  1432
tccaacatca aggaagatgg catttcta                                         28

<210>  1433
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  1433
tccaacatca aggaagatgg catttct                                          27

<210>  1434
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  1434
tccaacatca aggaagatgg catttc                                           26

<210>  1435
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1435
tccaacatca aggaagatgg cattt                                            25

<210>  1436
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1436
tccaacatca aggaagatgg catt                                             24

<210>  1437
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1437
tccaacatca aggaagatgg cat                                              23

<210>  1438
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1438
tccaacatca aggaagatgg ca                                               22

<210>  1439
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1439
tccaacatca aggaagatgg c                                                21

<210>  1440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1440
tccaacatca aggaagatgg                                                  20

<210>  1441
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1441
tccaacatca aggaagatg                                                   19

<210>  1442
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1442
tccaacatca aggaagat                                                    18

<210>  1443
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1443
tccaacatca aggaaga                                                     17

<210>  1444
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  1444
tccaacatca aggaag                                                      16

<210>  1445
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  1445
ccaacatcaa ggaagatggc atttctag                                         28

<210>  1446
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  1446
ccaacatcaa ggaagatggc atttcta                                          27

<210>  1447
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  1447
ccaacatcaa ggaagatggc atttct                                           26

<210>  1448
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<400>  1448
ccaacatcaa ggaagatggc atttc                                            25

<210>  1449
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1449
ccaacatcaa ggaagatggc attt                                             24

<210>  1450
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1450
ccaacatcaa ggaagatggc att                                              23

<210>  1451
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1451
ccaacatcaa ggaagatggc at                                               22

<210>  1452
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1452
ccaacatcaa ggaagatggc a                                                21

<210>  1453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1453
ccaacatcaa ggaagatggc                                                  20

<210>  1454
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1454
ccaacatcaa ggaagatgg                                                   19

<210>  1455
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1455
ccaacatcaa ggaagatg                                                    18

<210>  1456
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1456
ccaacatcaa ggaagat                                                     17

<210>  1457
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1457
ccaacatcaa ggaaga                                                      16

<210>  1458
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  1458
ccaacatcaa ggaag                                                       15

<210>  1459
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  1459
caacatcaag gaagatggca tttctag                                          27

<210>  1460
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  1460
caacatcaag gaagatggca tttcta                                           26

<210>  1461
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  1461
caacatcaag gaagatggca tttct                                            25

<210>  1462
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<400>  1462
caacatcaag gaagatggca tttc                                             24

<210>  1463
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1463
caacatcaag gaagatggca ttt                                              23

<210>  1464
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1464
caacatcaag gaagatggca tt                                               22

<210>  1465
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1465
caacatcaag gaagatggca t                                                21

<210>  1466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1466
caacatcaag gaagatggca                                                  20

<210>  1467
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  1467
caacatcaag gaagatggc                                                   19

<210>  1468
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1468
caacatcaag gaagatgg                                                    18

<210>  1469
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1469
caacatcaag gaagatg                                                     17

<210>  1470
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1470
caacatcaag gaagat                                                      16

<210>  1471
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1471
caacatcaag gaaga                                                       15

<210>  1472
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  1472
caacatcaag gaag                                                        14

<210>  1473
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  1473
aacatcaagg aagatggcat ttctag                                           26

<210>  1474
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  1474
aacatcaagg aagatggcat ttcta                                            25

<210>  1475
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  1475
aacatcaagg aagatggcat ttct                                             24

<210>  1476
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  1476
aacatcaagg aagatggcat ttc                                              23

<210>  1477
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1477
aacatcaagg aagatggcat tt                                               22

<210>  1478
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1478
aacatcaagg aagatggcat t                                                21

<210>  1479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1479
aacatcaagg aagatggcat                                                  20

<210>  1480
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1480
aacatcaagg aagatggca                                                   19

<210>  1481
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  1481
aacatcaagg aagatggc                                                    18

<210>  1482
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1482
aacatcaagg aagatgg                                                     17

<210>  1483
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1483
aacatcaagg aagatg                                                      16

<210>  1484
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1484
aacatcaagg aagat                                                       15

<210>  1485
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1485
aacatcaagg aaga                                                        14

<210>  1486
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  1486
aacatcaagg aag                                                         13

<210>  1487
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1487
acatcaagga agatggcatt tctag                                            25

<210>  1488
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1488
acatcaagga agatggcatt tcta                                             24

<210>  1489
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1489
acatcaagga agatggcatt tct                                              23

<210>  1490
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  1490
acatcaagga agatggcatt tc                                               22

<210>  1491
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1491
acatcaagga agatggcatt t                                                21

<210>  1492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1492
acatcaagga agatggcatt                                                  20

<210>  1493
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1493
acatcaagga agatggcat                                                   19

<210>  1494
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1494
acatcaagga agatggca                                                    18

<210>  1495
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  1495
acatcaagga agatggc                                                     17

<210>  1496
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1496
acatcaagga agatgg                                                      16

<210>  1497
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1497
acatcaagga agatg                                                       15

<210>  1498
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1498
acatcaagga agat                                                        14

<210>  1499
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1499
acatcaagga aga                                                         13

<210>  1500
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  1500
acatcaagga ag                                                          12

<210>  1501
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1501
catcaaggaa gatggcattt ctag                                             24

<210>  1502
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1502
catcaaggaa gatggcattt cta                                              23

<210>  1503
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1503
catcaaggaa gatggcattt ct                                               22

<210>  1504
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  1504
catcaaggaa gatggcattt c                                                21

<210>  1505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1505
catcaaggaa gatggcattt                                                  20

<210>  1506
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1506
catcaaggaa gatggcatt                                                   19

<210>  1507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1507
catcaaggaa gatggcat                                                    18

<210>  1508
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1508
catcaaggaa gatggca                                                     17

<210>  1509
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  1509
catcaaggaa gatggc                                                      16

<210>  1510
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1510
catcaaggaa gatgg                                                       15

<210>  1511
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1511
catcaaggaa gatg                                                        14

<210>  1512
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1512
catcaaggaa gat                                                         13

<210>  1513
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1513
catcaaggaa ga                                                          12

<210>  1514
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  1514
catcaaggaa g                                                           11

<210>  1515
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1515
atcaaggaag atggcatttc tag                                              23

<210>  1516
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1516
atcaaggaag atggcatttc ta                                               22

<210>  1517
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1517
atcaaggaag atggcatttc t                                                21

<210>  1518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  1518
atcaaggaag atggcatttc                                                  20

<210>  1519
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1519
atcaaggaag atggcattt                                                   19

<210>  1520
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1520
atcaaggaag atggcatt                                                    18

<210>  1521
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1521
atcaaggaag atggcat                                                     17

<210>  1522
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1522
atcaaggaag atggca                                                      16

<210>  1523
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  1523
atcaaggaag atggc                                                       15

<210>  1524
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1524
atcaaggaag atgg                                                        14

<210>  1525
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1525
atcaaggaag atg                                                         13

<210>  1526
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1526
atcaaggaag at                                                          12

<210>  1527
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1527
atcaaggaag a                                                           11

<210>  1528
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  1528
atcaaggaag                                                             10

<210>  1529
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1529
gguaaguucu guccaagc                                                    18

<210>  1530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1530
guaaguucug uccaagcc                                                    18

<210>  1531
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1531
agucgguaag uucugucc                                                    18

<210>  1532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1532
cuguccaagc ccgguuga                                                    18

<210>  1533
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1533
taaguucugu ccaag                                                       15

<210>  1534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1534
tucuguccaa gcccgguuga                                                  20

<210>  1535
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1535
tucuguccaa gcccgguug                                                   19

<210>  1536
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1536
tucuguccaa gcccgguu                                                    18

<210>  1537
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1537
tucuguccaa gcccggu                                                     17

<210>  1538
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1538
tucuguccaa gcccgg                                                      16

<210>  1539
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1539
tucuguccaa gcccg                                                       15

<210>  1540
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1540
tucuguccaa gccc                                                        14

<210>  1541
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1541
tucuguccaa gcc                                                         13

<210>  1542
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1542
tucuguccaa gc                                                          12

<210>  1543
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1543
tucuguccaa g                                                           11

<210>  1544
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1544
tucuguccaa                                                             10

<210>  1545
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1545
tucugucca                                                              9

<210>  1546
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1546
tucugucc                                                               8

<210>  1547
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1547
tcuguccaag cccgguuga                                                   19

<210>  1548
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1548
tcuguccaag cccgguug                                                    18

<210>  1549
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1549
tcuguccaag cccgguu                                                     17

<210>  1550
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1550
tcuguccaag cccggu                                                      16

<210>  1551
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1551
tcuguccaag cccgg                                                       15

<210>  1552
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1552
tcuguccaag cccg                                                        14

<210>  1553
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1553
tcuguccaag ccc                                                         13

<210>  1554
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1554
tcuguccaag cc                                                          12

<210>  1555
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1555
tcuguccaag c                                                           11

<210>  1556
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1556
tcuguccaag                                                             10

<210>  1557
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1557
tcuguccaa                                                              9

<210>  1558
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1558
tcugucca                                                               8

<210>  1559
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1559
cuguccaagc ccgguug                                                     17

<210>  1560
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1560
cuguccaagc ccgguu                                                      16

<210>  1561
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1561
cuguccaagc ccggu                                                       15

<210>  1562
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1562
cuguccaagc ccgg                                                        14

<210>  1563
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1563
cuguccaagc ccg                                                         13

<210>  1564
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1564
cuguccaagc cc                                                          12

<210>  1565
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1565
cuguccaagc c                                                           11

<210>  1566
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1566
cuguccaagc                                                             10

<210>  1567
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1567
cuguccaag                                                              9

<210>  1568
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1568
cuguccaa                                                               8

<210>  1569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1569
guucugucca agcccgguug                                                  20

<210>  1570
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1570
guucugucca agcccgguu                                                   19

<210>  1571
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1571
guucugucca agcccggu                                                    18

<210>  1572
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1572
guucugucca agcccgg                                                     17

<210>  1573
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1573
guucugucca agcccg                                                      16

<210>  1574
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1574
guucugucca agccc                                                       15

<210>  1575
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1575
guucugucca agcc                                                        14

<210>  1576
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1576
guucugucca agc                                                         13

<210>  1577
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1577
guucugucca ag                                                          12

<210>  1578
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1578
guucugucca a                                                           11

<210>  1579
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1579
guucugucca                                                             10

<210>  1580
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1580
guucugucc                                                              9

<210>  1581
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1581
guucuguc                                                               8

<210>  1582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1582
aguucugucc aagcccgguu                                                  20

<210>  1583
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1583
aguucugucc aagcccggu                                                   19

<210>  1584
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1584
aguucugucc aagcccgg                                                    18

<210>  1585
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1585
aguucugucc aagcccg                                                     17

<210>  1586
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1586
aguucugucc aagccc                                                      16

<210>  1587
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1587
aguucugucc aagcc                                                       15

<210>  1588
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1588
aguucugucc aagc                                                        14

<210>  1589
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1589
aguucugucc aag                                                         13

<210>  1590
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1590
aguucugucc aa                                                          12

<210>  1591
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1591
aguucugucc a                                                           11

<210>  1592
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1592
aguucugucc                                                             10

<210>  1593
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1593
aguucuguc                                                              9

<210>  1594
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1594
aguucugu                                                               8

<210>  1595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1595
aaguucuguc caagcccggu                                                  20

<210>  1596
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1596
aaguucuguc caagcccgg                                                   19

<210>  1597
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1597
aaguucuguc caagcccg                                                    18

<210>  1598
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1598
aaguucuguc caagccc                                                     17

<210>  1599
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1599
aaguucuguc caagcc                                                      16

<210>  1600
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1600
aaguucuguc caagc                                                       15

<210>  1601
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1601
aaguucuguc caag                                                        14

<210>  1602
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1602
aaguucuguc caa                                                         13

<210>  1603
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1603
aaguucuguc ca                                                          12

<210>  1604
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1604
aaguucuguc c                                                           11

<210>  1605
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1605
aaguucuguc                                                             10

<210>  1606
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1606
aaguucugu                                                              9

<210>  1607
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1607
aaguucug                                                               8

<210>  1608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1608
taaguucugu ccaagcccgg                                                  20

<210>  1609
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1609
taaguucugu ccaagcccg                                                   19

<210>  1610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1610
taaguucugu ccaagccc                                                    18

<210>  1611
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1611
taaguucugu ccaagcc                                                     17

<210>  1612
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1612
taaguucugu ccaagc                                                      16

<210>  1613
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1613
taaguucugu ccaa                                                        14

<210>  1614
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1614
taaguucugu cca                                                         13

<210>  1615
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1615
taaguucugu cc                                                          12

<210>  1616
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1616
taaguucugu c                                                           11

<210>  1617
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1617
taaguucugu                                                             10

<210>  1618
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1618
taaguucug                                                              9

<210>  1619
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1619
taaguucu                                                               8

<210>  1620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1620
guaaguucug uccaagcccg                                                  20

<210>  1621
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1621
guaaguucug uccaagccc                                                   19

<210>  1622
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1622
guaaguucug uccaagc                                                     17

<210>  1623
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1623
guaaguucug uccaag                                                      16

<210>  1624
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1624
guaaguucug uccaa                                                       15

<210>  1625
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1625
guaaguucug ucca                                                        14

<210>  1626
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1626
guaaguucug ucc                                                         13

<210>  1627
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1627
guaaguucug uc                                                          12

<210>  1628
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1628
guaaguucug u                                                           11

<210>  1629
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1629
guaaguucug                                                             10

<210>  1630
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1630
guaaguucu                                                              9

<210>  1631
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1631
guaaguuc                                                               8

<210>  1632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1632
gguaaguucu guccaagccc                                                  20

<210>  1633
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1633
gguaaguucu guccaagcc                                                   19

<210>  1634
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1634
gguaaguucu guccaag                                                     17

<210>  1635
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1635
gguaaguucu guccaa                                                      16

<210>  1636
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1636
gguaaguucu gucca                                                       15

<210>  1637
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1637
gguaaguucu gucc                                                        14

<210>  1638
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1638
gguaaguucu guc                                                         13

<210>  1639
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1639
gguaaguucu gu                                                          12

<210>  1640
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1640
gguaaguucu g                                                           11

<210>  1641
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1641
gguaaguucu                                                             10

<210>  1642
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1642
gguaaguuc                                                              9

<210>  1643
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1643
gguaaguu                                                               8

<210>  1644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1644
cgguaaguuc uguccaagcc                                                  20

<210>  1645
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1645
cgguaaguuc uguccaagc                                                   19

<210>  1646
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1646
cgguaaguuc uguccaag                                                    18

<210>  1647
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1647
cgguaaguuc uguccaa                                                     17

<210>  1648
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1648
cgguaaguuc ugucca                                                      16

<210>  1649
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1649
cgguaaguuc ugucc                                                       15

<210>  1650
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1650
cgguaaguuc uguc                                                        14

<210>  1651
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1651
cgguaaguuc ugu                                                         13

<210>  1652
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1652
cgguaaguuc ug                                                          12

<210>  1653
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1653
cgguaaguuc u                                                           11

<210>  1654
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1654
cgguaaguuc                                                             10

<210>  1655
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1655
cgguaaguu                                                              9

<210>  1656
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1656
cgguaagu                                                               8

<210>  1657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1657
tcgguaaguu cuguccaagc                                                  20

<210>  1658
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1658
tcgguaaguu cuguccaag                                                   19

<210>  1659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1659
tcgguaaguu cuguccaa                                                    18

<210>  1660
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1660
tcgguaaguu cugucca                                                     17

<210>  1661
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1661
tcgguaaguu cugucc                                                      16

<210>  1662
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1662
tcgguaaguu cuguc                                                       15

<210>  1663
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1663
tcgguaaguu cugu                                                        14

<210>  1664
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1664
tcgguaaguu cug                                                         13

<210>  1665
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1665
tcgguaaguu cu                                                          12

<210>  1666
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1666
tcgguaaguu c                                                           11

<210>  1667
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1667
tcgguaaguu                                                             10

<210>  1668
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1668
tcgguaagu                                                              9

<210>  1669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1669
gucgguaagu ucuguccaag                                                  20

<210>  1670
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1670
gucgguaagu ucuguccaa                                                   19

<210>  1671
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1671
gucgguaagu ucugucca                                                    18

<210>  1672
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1672
gucgguaagu ucugucc                                                     17

<210>  1673
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1673
gucgguaagu ucuguc                                                      16

<210>  1674
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1674
gucgguaagu ucugu                                                       15

<210>  1675
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1675
gucgguaagu ucug                                                        14

<210>  1676
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1676
gucgguaagu ucu                                                         13

<210>  1677
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1677
gucgguaagu uc                                                          12

<210>  1678
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1678
gucgguaagu u                                                           11

<210>  1679
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1679
gucgguaagu                                                             10

<210>  1680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1680
agucgguaag uucuguccaa                                                  20

<210>  1681
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1681
agucgguaag uucugucca                                                   19

<210>  1682
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1682
agucgguaag uucuguc                                                     17

<210>  1683
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1683
agucgguaag uucugu                                                      16

<210>  1684
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1684
agucgguaag uucug                                                       15

<210>  1685
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1685
agucgguaag uucu                                                        14

<210>  1686
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1686
agucgguaag uuc                                                         13

<210>  1687
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1687
agucgguaag uu                                                          12

<210>  1688
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1688
agucgguaag u                                                           11

<210>  1689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1689
cagucgguaa guucugucca                                                  20

<210>  1690
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1690
cagucgguaa guucugucc                                                   19

<210>  1691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1691
cagucgguaa guucuguc                                                    18

<210>  1692
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1692
cagucgguaa guucugu                                                     17

<210>  1693
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1693
cagucgguaa guucug                                                      16

<210>  1694
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1694
cagucgguaa guucu                                                       15

<210>  1695
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1695
cagucgguaa guuc                                                        14

<210>  1696
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1696
cagucgguaa guu                                                         13

<210>  1697
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1697
cagucgguaa gu                                                          12

<210>  1698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1698
ccagucggua aguucugucc                                                  20

<210>  1699
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1699
ccagucggua aguucuguc                                                   19

<210>  1700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1700
ccagucggua aguucugu                                                    18

<210>  1701
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1701
ccagucggua aguucug                                                     17

<210>  1702
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1702
ccagucggua aguucu                                                      16

<210>  1703
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1703
ccagucggua aguuc                                                       15

<210>  1704
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1704
ccagucggua aguu                                                        14

<210>  1705
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1705
ccagucggua agu                                                         13

<210>  1706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1706
gccagucggu aaguucuguc                                                  20

<210>  1707
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1707
gccagucggu aaguucugu                                                   19

<210>  1708
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1708
gccagucggu aaguucug                                                    18

<210>  1709
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1709
gccagucggu aaguucu                                                     17

<210>  1710
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1710
gccagucggu aaguuc                                                      16

<210>  1711
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1711
gccagucggu aaguu                                                       15

<210>  1712
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1712
gccagucggu aagu                                                        14

<210>  1713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1713
tcaaggaaga uggcauuucu                                                  20

<210>  1714
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1714
tcaaggaaga uggcauuucu ag                                               22

<210>  1715
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1715
tcaaggaaga uggcau                                                      16

<210>  1716
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1716
gaagauggca uuucu                                                       15

<210>  1717
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1717
tcaaggaaga uggcauuucu a                                                21

<210>  1718
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1718
tcaaggaaga uggcauuuc                                                   19

<210>  1719
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1719
tcaaggaaga uggcauuu                                                    18

<210>  1720
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1720
tcaaggaaga uggcauu                                                     17

<210>  1721
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1721
tcaaggaaga uggca                                                       15

<210>  1722
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1722
tcaaggaaga uggc                                                        14

<210>  1723
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1723
tcaaggaaga ugg                                                         13

<210>  1724
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1724
tcaaggaaga ug                                                          12

<210>  1725
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1725
tcaaggaaga u                                                           11

<210>  1726
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1726
tcaaggaaga                                                             10

<210>  1727
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1727
tcaaggaag                                                              9

<210>  1728
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1728
caaggaagau ggcauuucua g                                                21

<210>  1729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1729
caaggaagau ggcauuucua                                                  20

<210>  1730
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1730
caaggaagau ggcauuucu                                                   19

<210>  1731
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1731
caaggaagau ggcauuuc                                                    18

<210>  1732
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1732
caaggaagau ggcauuu                                                     17

<210>  1733
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1733
caaggaagau ggcauu                                                      16

<210>  1734
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1734
caaggaagau ggcau                                                       15

<210>  1735
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1735
caaggaagau ggca                                                        14

<210>  1736
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1736
caaggaagau ggc                                                         13

<210>  1737
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1737
caaggaagau gg                                                          12

<210>  1738
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1738
caaggaagau g                                                           11

<210>  1739
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1739
caaggaagau                                                             10

<210>  1740
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1740
caaggaaga                                                              9

<210>  1741
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1741
caaggaag                                                               8

<210>  1742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1742
aaggaagaug gcauuucuag                                                  20

<210>  1743
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1743
aaggaagaug gcauuucua                                                   19

<210>  1744
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1744
aaggaagaug gcauuucu                                                    18

<210>  1745
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1745
aaggaagaug gcauuuc                                                     17

<210>  1746
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1746
aaggaagaug gcauuu                                                      16

<210>  1747
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1747
aaggaagaug gcauu                                                       15

<210>  1748
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1748
aaggaagaug gcau                                                        14

<210>  1749
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1749
aaggaagaug gca                                                         13

<210>  1750
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1750
aaggaagaug gc                                                          12

<210>  1751
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1751
aaggaagaug g                                                           11

<210>  1752
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1752
aaggaagaug                                                             10

<210>  1753
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1753
aaggaagau                                                              9

<210>  1754
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1754
aaggaaga                                                               8

<210>  1755
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1755
aggaagaugg cauuucuag                                                   19

<210>  1756
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1756
aggaagaugg cauuucua                                                    18

<210>  1757
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1757
aggaagaugg cauuucu                                                     17

<210>  1758
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1758
aggaagaugg cauuuc                                                      16

<210>  1759
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1759
aggaagaugg cauuu                                                       15

<210>  1760
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1760
aggaagaugg cauu                                                        14

<210>  1761
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1761
aggaagaugg cau                                                         13

<210>  1762
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1762
aggaagaugg ca                                                          12

<210>  1763
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1763
aggaagaugg                                                             10

<210>  1764
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1764
aggaagaug                                                              9

<210>  1765
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1765
aggaagau                                                               8

<210>  1766
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1766
ggaagauggc auuucuag                                                    18

<210>  1767
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1767
ggaagauggc auuucua                                                     17

<210>  1768
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1768
ggaagauggc auuucu                                                      16

<210>  1769
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1769
ggaagauggc auuuc                                                       15

<210>  1770
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1770
ggaagauggc auuu                                                        14

<210>  1771
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1771
ggaagauggc auu                                                         13

<210>  1772
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1772
ggaagauggc au                                                          12

<210>  1773
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1773
ggaagauggc a                                                           11

<210>  1774
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1774
ggaagauggc                                                             10

<210>  1775
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1775
ggaagaug                                                               8

<210>  1776
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1776
gaagauggca uuucuag                                                     17

<210>  1777
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1777
gaagauggca uuucua                                                      16

<210>  1778
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1778
gaagauggca uuuc                                                        14

<210>  1779
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1779
gaagauggca uuu                                                         13

<210>  1780
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1780
gaagauggca uu                                                          12

<210>  1781
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1781
gaagauggca u                                                           11

<210>  1782
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1782
gaagauggca                                                             10

<210>  1783
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1783
gaagauggc                                                              9

<210>  1784
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1784
gaagaugg                                                               8

<210>  1785
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1785
aagauggcau uucuag                                                      16

<210>  1786
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1786
aagauggcau uucua                                                       15

<210>  1787
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1787
aagauggcau uucu                                                        14

<210>  1788
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1788
aagauggcau uuc                                                         13

<210>  1789
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1789
aagauggcau uu                                                          12

<210>  1790
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1790
aagauggcau u                                                           11

<210>  1791
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1791
aagauggcau                                                             10

<210>  1792
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1792
aagauggca                                                              9

<210>  1793
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1793
aagauggc                                                               8

<210>  1794
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1794
agauggcauu ucuag                                                       15

<210>  1795
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1795
agauggcauu ucua                                                        14

<210>  1796
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1796
agauggcauu ucu                                                         13

<210>  1797
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1797
agauggcauu uc                                                          12

<210>  1798
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1798
agauggcauu u                                                           11

<210>  1799
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1799
agauggcauu                                                             10

<210>  1800
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1800
agauggcau                                                              9

<210>  1801
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1801
agauggca                                                               8

<210>  1802
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1802
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  1803
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1803
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  1804
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1804
cuccaacauc aaggaagaug gcauuucu                                         28

<210>  1805
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1805
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  1806
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1806
cuccaacauc aaggaagaug gcauuu                                           26

<210>  1807
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1807
cuccaacauc aaggaagaug gcauu                                            25

<210>  1808
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1808
cuccaacauc aaggaagaug gcau                                             24

<210>  1809
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1809
cuccaacauc aaggaagaug gca                                              23

<210>  1810
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1810
cuccaacauc aaggaagaug gc                                               22

<210>  1811
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1811
cuccaacauc aaggaagaug g                                                21

<210>  1812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1812
cuccaacauc aaggaagaug                                                  20

<210>  1813
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1813
cuccaacauc aaggaagau                                                   19

<210>  1814
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1814
cuccaacauc aaggaaga                                                    18

<210>  1815
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1815
cuccaacauc aaggaag                                                     17

<210>  1816
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1816
tccaacauca aggaagaugg cauuucuag                                        29

<210>  1817
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1817
tccaacauca aggaagaugg cauuucua                                         28

<210>  1818
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1818
tccaacauca aggaagaugg cauuucu                                          27

<210>  1819
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1819
tccaacauca aggaagaugg cauuuc                                           26

<210>  1820
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1820
tccaacauca aggaagaugg cauuu                                            25

<210>  1821
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1821
tccaacauca aggaagaugg cauu                                             24

<210>  1822
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1822
tccaacauca aggaagaugg cau                                              23

<210>  1823
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1823
tccaacauca aggaagaugg ca                                               22

<210>  1824
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1824
tccaacauca aggaagaugg c                                                21

<210>  1825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1825
tccaacauca aggaagaugg                                                  20

<210>  1826
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1826
tccaacauca aggaagaug                                                   19

<210>  1827
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1827
tccaacauca aggaagau                                                    18

<210>  1828
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1828
tccaacauca aggaaga                                                     17

<210>  1829
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1829
tccaacauca aggaag                                                      16

<210>  1830
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1830
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  1831
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1831
ccaacaucaa ggaagauggc auuucua                                          27

<210>  1832
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1832
ccaacaucaa ggaagauggc auuucu                                           26

<210>  1833
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1833
ccaacaucaa ggaagauggc auuuc                                            25

<210>  1834
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1834
ccaacaucaa ggaagauggc auuu                                             24

<210>  1835
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1835
ccaacaucaa ggaagauggc auu                                              23

<210>  1836
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1836
ccaacaucaa ggaagauggc au                                               22

<210>  1837
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1837
ccaacaucaa ggaagauggc a                                                21

<210>  1838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1838
ccaacaucaa ggaagauggc                                                  20

<210>  1839
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1839
ccaacaucaa ggaagaugg                                                   19

<210>  1840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1840
ccaacaucaa ggaagaug                                                    18

<210>  1841
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1841
ccaacaucaa ggaagau                                                     17

<210>  1842
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1842
ccaacaucaa ggaaga                                                      16

<210>  1843
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1843
ccaacaucaa ggaag                                                       15

<210>  1844
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1844
caacaucaag gaagauggca uuucuag                                          27

<210>  1845
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1845
caacaucaag gaagauggca uuucua                                           26

<210>  1846
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1846
caacaucaag gaagauggca uuucu                                            25

<210>  1847
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1847
caacaucaag gaagauggca uuuc                                             24

<210>  1848
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1848
caacaucaag gaagauggca uuu                                              23

<210>  1849
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1849
caacaucaag gaagauggca uu                                               22

<210>  1850
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1850
caacaucaag gaagauggca u                                                21

<210>  1851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1851
caacaucaag gaagauggca                                                  20

<210>  1852
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1852
caacaucaag gaagauggc                                                   19

<210>  1853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1853
caacaucaag gaagaugg                                                    18

<210>  1854
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1854
caacaucaag gaagaug                                                     17

<210>  1855
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1855
caacaucaag gaagau                                                      16

<210>  1856
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1856
caacaucaag gaaga                                                       15

<210>  1857
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1857
caacaucaag gaag                                                        14

<210>  1858
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1858
aacaucaagg aagauggcau uucuag                                           26

<210>  1859
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1859
aacaucaagg aagauggcau uucua                                            25

<210>  1860
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1860
aacaucaagg aagauggcau uucu                                             24

<210>  1861
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1861
aacaucaagg aagauggcau uuc                                              23

<210>  1862
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1862
aacaucaagg aagauggcau uu                                               22

<210>  1863
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1863
aacaucaagg aagauggcau u                                                21

<210>  1864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1864
aacaucaagg aagauggcau                                                  20

<210>  1865
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1865
aacaucaagg aagauggca                                                   19

<210>  1866
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1866
aacaucaagg aagauggc                                                    18

<210>  1867
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1867
aacaucaagg aagaugg                                                     17

<210>  1868
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1868
aacaucaagg aagaug                                                      16

<210>  1869
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1869
aacaucaagg aagau                                                       15

<210>  1870
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1870
aacaucaagg aaga                                                        14

<210>  1871
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1871
aacaucaagg aag                                                         13

<210>  1872
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1872
acaucaagga agauggcauu ucuag                                            25

<210>  1873
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1873
acaucaagga agauggcauu ucua                                             24

<210>  1874
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1874
acaucaagga agauggcauu ucu                                              23

<210>  1875
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1875
acaucaagga agauggcauu uc                                               22

<210>  1876
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1876
acaucaagga agauggcauu u                                                21

<210>  1877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1877
acaucaagga agauggcauu                                                  20

<210>  1878
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1878
acaucaagga agauggcau                                                   19

<210>  1879
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1879
acaucaagga agauggca                                                    18

<210>  1880
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1880
acaucaagga agauggc                                                     17

<210>  1881
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1881
acaucaagga agaugg                                                      16

<210>  1882
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1882
acaucaagga agaug                                                       15

<210>  1883
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1883
acaucaagga agau                                                        14

<210>  1884
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1884
acaucaagga aga                                                         13

<210>  1885
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1885
acaucaagga ag                                                          12

<210>  1886
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1886
caucaaggaa gauggcauuu cuag                                             24

<210>  1887
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1887
caucaaggaa gauggcauuu cua                                              23

<210>  1888
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1888
caucaaggaa gauggcauuu cu                                               22

<210>  1889
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1889
caucaaggaa gauggcauuu c                                                21

<210>  1890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1890
caucaaggaa gauggcauuu                                                  20

<210>  1891
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1891
caucaaggaa gauggcauu                                                   19

<210>  1892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1892
caucaaggaa gauggcau                                                    18

<210>  1893
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1893
caucaaggaa gauggca                                                     17

<210>  1894
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1894
caucaaggaa gauggc                                                      16

<210>  1895
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1895
caucaaggaa gaugg                                                       15

<210>  1896
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1896
caucaaggaa gaug                                                        14

<210>  1897
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1897
caucaaggaa gau                                                         13

<210>  1898
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1898
caucaaggaa ga                                                          12

<210>  1899
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1899
caucaaggaa g                                                           11

<210>  1900
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1900
aucaaggaag auggcauuuc uag                                              23

<210>  1901
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1901
aucaaggaag auggcauuuc ua                                               22

<210>  1902
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1902
aucaaggaag auggcauuuc u                                                21

<210>  1903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1903
aucaaggaag auggcauuuc                                                  20

<210>  1904
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1904
aucaaggaag auggcauuu                                                   19

<210>  1905
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1905
aucaaggaag auggcauu                                                    18

<210>  1906
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1906
aucaaggaag auggcau                                                     17

<210>  1907
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1907
aucaaggaag auggca                                                      16

<210>  1908
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1908
aucaaggaag auggc                                                       15

<210>  1909
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1909
aucaaggaag augg                                                        14

<210>  1910
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1910
aucaaggaag aug                                                         13

<210>  1911
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1911
aucaaggaag au                                                          12

<210>  1912
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1912
aucaaggaag a                                                           11

<210>  1913
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  1913
aucaaggaag                                                             10

<210>  1914
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1914
gguaaguucu guccaagc                                                    18

<210>  1915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1915
guaaguucug uccaagcc                                                    18

<210>  1916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1916
agucgguaag uucugucc                                                    18

<210>  1917
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1917
cuguccaagc ccgguuga                                                    18

<210>  1918
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1918
uaaguucugu ccaag                                                       15

<210>  1919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  1919
uucuguccaa gcccgguuga                                                  20

<210>  1920
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  1920
uucuguccaa gcccgguug                                                   19

<210>  1921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1921
uucuguccaa gcccggut                                                    18

<210>  1922
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1922
uucuguccaa gcccggt                                                     17

<210>  1923
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1923
uucuguccaa gcccgg                                                      16

<210>  1924
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1924
uucuguccaa gcccg                                                       15

<210>  1925
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1925
uucuguccaa gccc                                                        14

<210>  1926
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1926
uucuguccaa gcc                                                         13

<210>  1927
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  1927
uucuguccaa gc                                                          12

<210>  1928
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  1928
uucuguccaa g                                                           11

<210>  1929
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  1929
uucuguccaa                                                             10

<210>  1930
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  1930
uucugucca                                                              9

<210>  1931
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  1931
uucugucc                                                               8

<210>  1932
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  1932
ucuguccaag cccgguuga                                                   19

<210>  1933
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1933
ucuguccaag cccgguug                                                    18

<210>  1934
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1934
ucuguccaag cccggut                                                     17

<210>  1935
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1935
ucuguccaag cccggt                                                      16

<210>  1936
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1936
ucuguccaag cccgg                                                       15

<210>  1937
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1937
ucuguccaag cccg                                                        14

<210>  1938
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1938
ucuguccaag ccc                                                         13

<210>  1939
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  1939
ucuguccaag cc                                                          12

<210>  1940
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  1940
ucuguccaag c                                                           11

<210>  1941
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  1941
ucuguccaag                                                             10

<210>  1942
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  1942
ucuguccaa                                                              9

<210>  1943
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  1943
ucugucca                                                               8

<210>  1944
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1944
cuguccaagc ccgguug                                                     17

<210>  1945
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1945
cuguccaagc ccggut                                                      16

<210>  1946
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1946
cuguccaagc ccggt                                                       15

<210>  1947
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1947
cuguccaagc ccgg                                                        14

<210>  1948
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1948
cuguccaagc ccg                                                         13

<210>  1949
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  1949
cuguccaagc cc                                                          12

<210>  1950
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  1950
cuguccaagc c                                                           11

<210>  1951
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  1951
cuguccaagc                                                             10

<210>  1952
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  1952
cuguccaag                                                              9

<210>  1953
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  1953
cuguccaa                                                               8

<210>  1954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  1954
guucugucca agcccgguug                                                  20

<210>  1955
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  1955
guucugucca agcccggut                                                   19

<210>  1956
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1956
guucugucca agcccggt                                                    18

<210>  1957
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1957
guucugucca agcccgg                                                     17

<210>  1958
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1958
guucugucca agcccg                                                      16

<210>  1959
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1959
guucugucca agccc                                                       15

<210>  1960
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1960
guucugucca agcc                                                        14

<210>  1961
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1961
guucugucca agc                                                         13

<210>  1962
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  1962
guucugucca ag                                                          12

<210>  1963
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  1963
guucugucca a                                                           11

<210>  1964
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  1964
guucugucca                                                             10

<210>  1965
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  1965
guucugucc                                                              9

<210>  1966
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  1966
guucuguc                                                               8

<210>  1967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  1967
aguucugucc aagcccggut                                                  20

<210>  1968
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  1968
aguucugucc aagcccggt                                                   19

<210>  1969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1969
aguucugucc aagcccgg                                                    18

<210>  1970
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1970
aguucugucc aagcccg                                                     17

<210>  1971
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1971
aguucugucc aagccc                                                      16

<210>  1972
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1972
aguucugucc aagcc                                                       15

<210>  1973
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1973
aguucugucc aagc                                                        14

<210>  1974
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1974
aguucugucc aag                                                         13

<210>  1975
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  1975
aguucugucc aa                                                          12

<210>  1976
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  1976
aguucugucc a                                                           11

<210>  1977
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  1977
aguucugucc                                                             10

<210>  1978
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  1978
aguucuguc                                                              9

<210>  1979
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  1979
aguucugt                                                               8

<210>  1980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  1980
aaguucuguc caagcccggt                                                  20

<210>  1981
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  1981
aaguucuguc caagcccgg                                                   19

<210>  1982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1982
aaguucuguc caagcccg                                                    18

<210>  1983
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1983
aaguucuguc caagccc                                                     17

<210>  1984
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1984
aaguucuguc caagcc                                                      16

<210>  1985
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  1985
aaguucuguc caagc                                                       15

<210>  1986
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1986
aaguucuguc caag                                                        14

<210>  1987
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1987
aaguucuguc caa                                                         13

<210>  1988
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  1988
aaguucuguc ca                                                          12

<210>  1989
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  1989
aaguucuguc c                                                           11

<210>  1990
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  1990
aaguucuguc                                                             10

<210>  1991
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  1991
aaguucugt                                                              9

<210>  1992
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  1992
aaguucug                                                               8

<210>  1993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  1993
uaaguucugu ccaagcccgg                                                  20

<210>  1994
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  1994
uaaguucugu ccaagcccg                                                   19

<210>  1995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  1995
uaaguucugu ccaagccc                                                    18

<210>  1996
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  1996
uaaguucugu ccaagcc                                                     17

<210>  1997
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  1997
uaaguucugu ccaagc                                                      16

<210>  1998
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  1998
uaaguucugu ccaa                                                        14

<210>  1999
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  1999
uaaguucugu cca                                                         13

<210>  2000
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2000
uaaguucugu cc                                                          12

<210>  2001
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2001
uaaguucugu c                                                           11

<210>  2002
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2002
uaaguucugt                                                             10

<210>  2003
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2003
uaaguucug                                                              9

<210>  2004
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2004
uaaguuct                                                               8

<210>  2005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2005
guaaguucug uccaagcccg                                                  20

<210>  2006
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2006
guaaguucug uccaagccc                                                   19

<210>  2007
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2007
guaaguucug uccaagc                                                     17

<210>  2008
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2008
guaaguucug uccaag                                                      16

<210>  2009
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2009
guaaguucug uccaa                                                       15

<210>  2010
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2010
guaaguucug ucca                                                        14

<210>  2011
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2011
guaaguucug ucc                                                         13

<210>  2012
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2012
guaaguucug uc                                                          12

<210>  2013
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2013
guaaguucug t                                                           11

<210>  2014
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2014
guaaguucug                                                             10

<210>  2015
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2015
guaaguuct                                                              9

<210>  2016
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2016
guaaguuc                                                               8

<210>  2017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2017
gguaaguucu guccaagccc                                                  20

<210>  2018
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2018
gguaaguucu guccaagcc                                                   19

<210>  2019
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2019
gguaaguucu guccaag                                                     17

<210>  2020
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2020
gguaaguucu guccaa                                                      16

<210>  2021
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2021
gguaaguucu gucca                                                       15

<210>  2022
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2022
gguaaguucu gucc                                                        14

<210>  2023
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2023
gguaaguucu guc                                                         13

<210>  2024
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2024
gguaaguucu gt                                                          12

<210>  2025
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2025
gguaaguucu g                                                           11

<210>  2026
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2026
gguaaguuct                                                             10

<210>  2027
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2027
gguaaguuc                                                              9

<210>  2028
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2028
gguaagut                                                               8

<210>  2029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2029
cgguaaguuc uguccaagcc                                                  20

<210>  2030
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2030
cgguaaguuc uguccaagc                                                   19

<210>  2031
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2031
cgguaaguuc uguccaag                                                    18

<210>  2032
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2032
cgguaaguuc uguccaa                                                     17

<210>  2033
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2033
cgguaaguuc ugucca                                                      16

<210>  2034
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2034
cgguaaguuc ugucc                                                       15

<210>  2035
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2035
cgguaaguuc uguc                                                        14

<210>  2036
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2036
cgguaaguuc ugt                                                         13

<210>  2037
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2037
cgguaaguuc ug                                                          12

<210>  2038
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2038
cgguaaguuc t                                                           11

<210>  2039
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2039
cgguaaguuc                                                             10

<210>  2040
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2040
cgguaagut                                                              9

<210>  2041
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2041
cgguaagt                                                               8

<210>  2042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2042
ucgguaaguu cuguccaagc                                                  20

<210>  2043
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2043
ucgguaaguu cuguccaag                                                   19

<210>  2044
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2044
ucgguaaguu cuguccaa                                                    18

<210>  2045
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2045
ucgguaaguu cugucca                                                     17

<210>  2046
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2046
ucgguaaguu cugucc                                                      16

<210>  2047
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2047
ucgguaaguu cuguc                                                       15

<210>  2048
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2048
ucgguaaguu cugt                                                        14

<210>  2049
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2049
ucgguaaguu cug                                                         13

<210>  2050
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2050
ucgguaaguu ct                                                          12

<210>  2051
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2051
ucgguaaguu c                                                           11

<210>  2052
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2052
ucgguaagut                                                             10

<210>  2053
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2053
ucgguaagt                                                              9

<210>  2054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2054
gucgguaagu ucuguccaag                                                  20

<210>  2055
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2055
gucgguaagu ucuguccaa                                                   19

<210>  2056
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2056
gucgguaagu ucugucca                                                    18

<210>  2057
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2057
gucgguaagu ucugucc                                                     17

<210>  2058
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2058
gucgguaagu ucuguc                                                      16

<210>  2059
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2059
gucgguaagu ucugt                                                       15

<210>  2060
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2060
gucgguaagu ucug                                                        14

<210>  2061
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2061
gucgguaagu uct                                                         13

<210>  2062
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2062
gucgguaagu uc                                                          12

<210>  2063
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2063
gucgguaagu t                                                           11

<210>  2064
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2064
gucgguaagt                                                             10

<210>  2065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2065
agucgguaag uucuguccaa                                                  20

<210>  2066
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2066
agucgguaag uucugucca                                                   19

<210>  2067
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2067
agucgguaag uucuguc                                                     17

<210>  2068
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2068
agucgguaag uucugt                                                      16

<210>  2069
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2069
agucgguaag uucug                                                       15

<210>  2070
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2070
agucgguaag uuct                                                        14

<210>  2071
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2071
agucgguaag uuc                                                         13

<210>  2072
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2072
agucgguaag ut                                                          12

<210>  2073
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2073
agucgguaag t                                                           11

<210>  2074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2074
cagucgguaa guucugucca                                                  20

<210>  2075
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2075
cagucgguaa guucugucc                                                   19

<210>  2076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2076
cagucgguaa guucuguc                                                    18

<210>  2077
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2077
cagucgguaa guucugt                                                     17

<210>  2078
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2078
cagucgguaa guucug                                                      16

<210>  2079
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2079
cagucgguaa guuct                                                       15

<210>  2080
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2080
cagucgguaa guuc                                                        14

<210>  2081
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2081
cagucgguaa gut                                                         13

<210>  2082
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2082
cagucgguaa gt                                                          12

<210>  2083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2083
ccagucggua aguucugucc                                                  20

<210>  2084
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2084
ccagucggua aguucuguc                                                   19

<210>  2085
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2085
ccagucggua aguucugt                                                    18

<210>  2086
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2086
ccagucggua aguucug                                                     17

<210>  2087
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2087
ccagucggua aguuct                                                      16

<210>  2088
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2088
ccagucggua aguuc                                                       15

<210>  2089
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2089
ccagucggua agut                                                        14

<210>  2090
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2090
ccagucggua agt                                                         13

<210>  2091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2091
gccagucggu aaguucuguc                                                  20

<210>  2092
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2092
gccagucggu aaguucugt                                                   19

<210>  2093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2093
gccagucggu aaguucug                                                    18

<210>  2094
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2094
gccagucggu aaguuct                                                     17

<210>  2095
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2095
gccagucggu aaguuc                                                      16

<210>  2096
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2096
gccagucggu aagut                                                       15

<210>  2097
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2097
gccagucggu aagt                                                        14

<210>  2098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2098
ucaaggaaga uggcauuuct                                                  20

<210>  2099
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2099
ucaaggaaga uggcauuucu ag                                               22

<210>  2100
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2100
ucaaggaaga uggcat                                                      16

<210>  2101
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2101
gaagauggca uuuct                                                       15

<210>  2102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2102
ucaaggaaga uggcauuucu a                                                21

<210>  2103
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2103
ucaaggaaga uggcauuuc                                                   19

<210>  2104
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2104
ucaaggaaga uggcauut                                                    18

<210>  2105
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2105
ucaaggaaga uggcaut                                                     17

<210>  2106
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2106
ucaaggaaga uggca                                                       15

<210>  2107
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2107
ucaaggaaga uggc                                                        14

<210>  2108
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2108
ucaaggaaga ugg                                                         13

<210>  2109
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2109
ucaaggaaga ug                                                          12

<210>  2110
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2110
ucaaggaaga t                                                           11

<210>  2111
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2111
ucaaggaaga                                                             10

<210>  2112
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2112
ucaaggaag                                                              9

<210>  2113
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2113
caaggaagau ggcauuucua g                                                21

<210>  2114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2114
caaggaagau ggcauuucua                                                  20

<210>  2115
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2115
caaggaagau ggcauuuct                                                   19

<210>  2116
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2116
caaggaagau ggcauuuc                                                    18

<210>  2117
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2117
caaggaagau ggcauut                                                     17

<210>  2118
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2118
caaggaagau ggcaut                                                      16

<210>  2119
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2119
caaggaagau ggcat                                                       15

<210>  2120
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2120
caaggaagau ggca                                                        14

<210>  2121
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2121
caaggaagau ggc                                                         13

<210>  2122
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2122
caaggaagau gg                                                          12

<210>  2123
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2123
caaggaagau g                                                           11

<210>  2124
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2124
caaggaagat                                                             10

<210>  2125
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2125
caaggaaga                                                              9

<210>  2126
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2126
caaggaag                                                               8

<210>  2127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2127
aaggaagaug gcauuucuag                                                  20

<210>  2128
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2128
aaggaagaug gcauuucua                                                   19

<210>  2129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2129
aaggaagaug gcauuuct                                                    18

<210>  2130
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2130
aaggaagaug gcauuuc                                                     17

<210>  2131
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2131
aaggaagaug gcauut                                                      16

<210>  2132
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2132
aaggaagaug gcaut                                                       15

<210>  2133
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2133
aaggaagaug gcat                                                        14

<210>  2134
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2134
aaggaagaug gca                                                         13

<210>  2135
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2135
aaggaagaug gc                                                          12

<210>  2136
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2136
aaggaagaug g                                                           11

<210>  2137
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2137
aaggaagaug                                                             10

<210>  2138
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2138
aaggaagat                                                              9

<210>  2139
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2139
aaggaaga                                                               8

<210>  2140
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2140
aggaagaugg cauuucuag                                                   19

<210>  2141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2141
aggaagaugg cauuucua                                                    18

<210>  2142
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2142
aggaagaugg cauuuct                                                     17

<210>  2143
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2143
aggaagaugg cauuuc                                                      16

<210>  2144
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2144
aggaagaugg cauut                                                       15

<210>  2145
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2145
aggaagaugg caut                                                        14

<210>  2146
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2146
aggaagaugg cat                                                         13

<210>  2147
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2147
aggaagaugg ca                                                          12

<210>  2148
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2148
aggaagaugg                                                             10

<210>  2149
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2149
aggaagaug                                                              9

<210>  2150
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2150
aggaagat                                                               8

<210>  2151
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2151
ggaagauggc auuucuag                                                    18

<210>  2152
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2152
ggaagauggc auuucua                                                     17

<210>  2153
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2153
ggaagauggc auuuct                                                      16

<210>  2154
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2154
ggaagauggc auuuc                                                       15

<210>  2155
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2155
ggaagauggc auut                                                        14

<210>  2156
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2156
ggaagauggc aut                                                         13

<210>  2157
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2157
ggaagauggc at                                                          12

<210>  2158
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2158
ggaagauggc a                                                           11

<210>  2159
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2159
ggaagauggc                                                             10

<210>  2160
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2160
ggaagaug                                                               8

<210>  2161
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2161
gaagauggca uuucuag                                                     17

<210>  2162
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2162
gaagauggca uuucua                                                      16

<210>  2163
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2163
gaagauggca uuuc                                                        14

<210>  2164
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2164
gaagauggca uut                                                         13

<210>  2165
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2165
gaagauggca ut                                                          12

<210>  2166
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2166
gaagauggca t                                                           11

<210>  2167
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2167
gaagauggca                                                             10

<210>  2168
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2168
gaagauggc                                                              9

<210>  2169
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2169
gaagaugg                                                               8

<210>  2170
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2170
aagauggcau uucuag                                                      16

<210>  2171
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2171
aagauggcau uucua                                                       15

<210>  2172
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2172
aagauggcau uuct                                                        14

<210>  2173
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2173
aagauggcau uuc                                                         13

<210>  2174
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2174
aagauggcau ut                                                          12

<210>  2175
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2175
aagauggcau t                                                           11

<210>  2176
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2176
aagauggcat                                                             10

<210>  2177
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2177
aagauggca                                                              9

<210>  2178
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2178
aagauggc                                                               8

<210>  2179
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2179
agauggcauu ucuag                                                       15

<210>  2180
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2180
agauggcauu ucua                                                        14

<210>  2181
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2181
agauggcauu uct                                                         13

<210>  2182
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2182
agauggcauu uc                                                          12

<210>  2183
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2183
agauggcauu t                                                           11

<210>  2184
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2184
agauggcaut                                                             10

<210>  2185
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2185
agauggcat                                                              9

<210>  2186
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2186
agauggca                                                               8

<210>  2187
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  2187
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  2188
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  2188
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  2189
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  2189
cuccaacauc aaggaagaug gcauuuct                                         28

<210>  2190
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2190
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  2191
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2191
cuccaacauc aaggaagaug gcauut                                           26

<210>  2192
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2192
cuccaacauc aaggaagaug gcaut                                            25

<210>  2193
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2193
cuccaacauc aaggaagaug gcat                                             24

<210>  2194
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2194
cuccaacauc aaggaagaug gca                                              23

<210>  2195
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2195
cuccaacauc aaggaagaug gc                                               22

<210>  2196
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2196
cuccaacauc aaggaagaug g                                                21

<210>  2197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2197
cuccaacauc aaggaagaug                                                  20

<210>  2198
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2198
cuccaacauc aaggaagat                                                   19

<210>  2199
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2199
cuccaacauc aaggaaga                                                    18

<210>  2200
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2200
cuccaacauc aaggaag                                                     17

<210>  2201
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  2201
uccaacauca aggaagaugg cauuucuag                                        29

<210>  2202
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  2202
uccaacauca aggaagaugg cauuucua                                         28

<210>  2203
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2203
uccaacauca aggaagaugg cauuuct                                          27

<210>  2204
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2204
uccaacauca aggaagaugg cauuuc                                           26

<210>  2205
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2205
uccaacauca aggaagaugg cauut                                            25

<210>  2206
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2206
uccaacauca aggaagaugg caut                                             24

<210>  2207
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2207
uccaacauca aggaagaugg cat                                              23

<210>  2208
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2208
uccaacauca aggaagaugg ca                                               22

<210>  2209
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2209
uccaacauca aggaagaugg c                                                21

<210>  2210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2210
uccaacauca aggaagaugg                                                  20

<210>  2211
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2211
uccaacauca aggaagaug                                                   19

<210>  2212
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2212
uccaacauca aggaagat                                                    18

<210>  2213
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2213
uccaacauca aggaaga                                                     17

<210>  2214
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2214
uccaacauca aggaag                                                      16

<210>  2215
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  2215
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  2216
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2216
ccaacaucaa ggaagauggc auuucua                                          27

<210>  2217
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2217
ccaacaucaa ggaagauggc auuuct                                           26

<210>  2218
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2218
ccaacaucaa ggaagauggc auuuc                                            25

<210>  2219
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2219
ccaacaucaa ggaagauggc auut                                             24

<210>  2220
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2220
ccaacaucaa ggaagauggc aut                                              23

<210>  2221
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2221
ccaacaucaa ggaagauggc at                                               22

<210>  2222
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2222
ccaacaucaa ggaagauggc a                                                21

<210>  2223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2223
ccaacaucaa ggaagauggc                                                  20

<210>  2224
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2224
ccaacaucaa ggaagaugg                                                   19

<210>  2225
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2225
ccaacaucaa ggaagaug                                                    18

<210>  2226
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2226
ccaacaucaa ggaagat                                                     17

<210>  2227
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2227
ccaacaucaa ggaaga                                                      16

<210>  2228
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2228
ccaacaucaa ggaag                                                       15

<210>  2229
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2229
caacaucaag gaagauggca uuucuag                                          27

<210>  2230
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2230
caacaucaag gaagauggca uuucua                                           26

<210>  2231
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2231
caacaucaag gaagauggca uuuct                                            25

<210>  2232
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2232
caacaucaag gaagauggca uuuc                                             24

<210>  2233
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2233
caacaucaag gaagauggca uut                                              23

<210>  2234
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2234
caacaucaag gaagauggca ut                                               22

<210>  2235
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2235
caacaucaag gaagauggca t                                                21

<210>  2236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2236
caacaucaag gaagauggca                                                  20

<210>  2237
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2237
caacaucaag gaagauggc                                                   19

<210>  2238
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2238
caacaucaag gaagaugg                                                    18

<210>  2239
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2239
caacaucaag gaagaug                                                     17

<210>  2240
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2240
caacaucaag gaagat                                                      16

<210>  2241
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2241
caacaucaag gaaga                                                       15

<210>  2242
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2242
caacaucaag gaag                                                        14

<210>  2243
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2243
aacaucaagg aagauggcau uucuag                                           26

<210>  2244
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2244
aacaucaagg aagauggcau uucua                                            25

<210>  2245
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2245
aacaucaagg aagauggcau uuct                                             24

<210>  2246
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2246
aacaucaagg aagauggcau uuc                                              23

<210>  2247
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2247
aacaucaagg aagauggcau ut                                               22

<210>  2248
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2248
aacaucaagg aagauggcau t                                                21

<210>  2249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2249
aacaucaagg aagauggcat                                                  20

<210>  2250
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2250
aacaucaagg aagauggca                                                   19

<210>  2251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2251
aacaucaagg aagauggc                                                    18

<210>  2252
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2252
aacaucaagg aagaugg                                                     17

<210>  2253
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2253
aacaucaagg aagaug                                                      16

<210>  2254
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2254
aacaucaagg aagat                                                       15

<210>  2255
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2255
aacaucaagg aaga                                                        14

<210>  2256
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2256
aacaucaagg aag                                                         13

<210>  2257
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2257
acaucaagga agauggcauu ucuag                                            25

<210>  2258
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2258
acaucaagga agauggcauu ucua                                             24

<210>  2259
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2259
acaucaagga agauggcauu uct                                              23

<210>  2260
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2260
acaucaagga agauggcauu uc                                               22

<210>  2261
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2261
acaucaagga agauggcauu t                                                21

<210>  2262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2262
acaucaagga agauggcaut                                                  20

<210>  2263
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2263
acaucaagga agauggcat                                                   19

<210>  2264
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2264
acaucaagga agauggca                                                    18

<210>  2265
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2265
acaucaagga agauggc                                                     17

<210>  2266
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2266
acaucaagga agaugg                                                      16

<210>  2267
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2267
acaucaagga agaug                                                       15

<210>  2268
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2268
acaucaagga agat                                                        14

<210>  2269
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2269
acaucaagga aga                                                         13

<210>  2270
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2270
acaucaagga ag                                                          12

<210>  2271
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2271
caucaaggaa gauggcauuu cuag                                             24

<210>  2272
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2272
caucaaggaa gauggcauuu cua                                              23

<210>  2273
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2273
caucaaggaa gauggcauuu ct                                               22

<210>  2274
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2274
caucaaggaa gauggcauuu c                                                21

<210>  2275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2275
caucaaggaa gauggcauut                                                  20

<210>  2276
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2276
caucaaggaa gauggcaut                                                   19

<210>  2277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2277
caucaaggaa gauggcat                                                    18

<210>  2278
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2278
caucaaggaa gauggca                                                     17

<210>  2279
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2279
caucaaggaa gauggc                                                      16

<210>  2280
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2280
caucaaggaa gaugg                                                       15

<210>  2281
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2281
caucaaggaa gaug                                                        14

<210>  2282
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2282
caucaaggaa gat                                                         13

<210>  2283
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2283
caucaaggaa ga                                                          12

<210>  2284
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2284
caucaaggaa g                                                           11

<210>  2285
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2285
aucaaggaag auggcauuuc uag                                              23

<210>  2286
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2286
aucaaggaag auggcauuuc ua                                               22

<210>  2287
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2287
aucaaggaag auggcauuuc t                                                21

<210>  2288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2288
aucaaggaag auggcauuuc                                                  20

<210>  2289
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2289
aucaaggaag auggcauut                                                   19

<210>  2290
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2290
aucaaggaag auggcaut                                                    18

<210>  2291
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2291
aucaaggaag auggcat                                                     17

<210>  2292
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2292
aucaaggaag auggca                                                      16

<210>  2293
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2293
aucaaggaag auggc                                                       15

<210>  2294
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2294
aucaaggaag augg                                                        14

<210>  2295
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2295
aucaaggaag aug                                                         13

<210>  2296
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2296
aucaaggaag at                                                          12

<210>  2297
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2297
aucaaggaag a                                                           11

<210>  2298
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2298
aucaaggaag                                                             10

<210>  2299
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2299
gguaaguucu guccaagc                                                    18

<210>  2300
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2300
guaaguucug uccaagcc                                                    18

<210>  2301
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2301
agucgguaag uucugucc                                                    18

<210>  2302
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2302
cuguccaagc ccgguuga                                                    18

<210>  2303
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2303
taaguucugu ccaag                                                       15

<210>  2304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2304
tucuguccaa gcccgguuga                                                  20

<210>  2305
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2305
tucuguccaa gcccgguug                                                   19

<210>  2306
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2306
tucuguccaa gcccggut                                                    18

<210>  2307
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2307
tucuguccaa gcccggt                                                     17

<210>  2308
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2308
tucuguccaa gcccgg                                                      16

<210>  2309
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2309
tucuguccaa gcccg                                                       15

<210>  2310
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2310
tucuguccaa gccc                                                        14

<210>  2311
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2311
tucuguccaa gcc                                                         13

<210>  2312
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2312
tucuguccaa gc                                                          12

<210>  2313
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2313
tucuguccaa g                                                           11

<210>  2314
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2314
tucuguccaa                                                             10

<210>  2315
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2315
tucugucca                                                              9

<210>  2316
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2316
tucugucc                                                               8

<210>  2317
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2317
tcuguccaag cccgguuga                                                   19

<210>  2318
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2318
tcuguccaag cccgguug                                                    18

<210>  2319
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2319
tcuguccaag cccggut                                                     17

<210>  2320
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2320
tcuguccaag cccggt                                                      16

<210>  2321
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2321
tcuguccaag cccgg                                                       15

<210>  2322
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2322
tcuguccaag cccg                                                        14

<210>  2323
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2323
tcuguccaag ccc                                                         13

<210>  2324
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2324
tcuguccaag cc                                                          12

<210>  2325
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2325
tcuguccaag c                                                           11

<210>  2326
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2326
tcuguccaag                                                             10

<210>  2327
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2327
tcuguccaa                                                              9

<210>  2328
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2328
tcugucca                                                               8

<210>  2329
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2329
cuguccaagc ccgguug                                                     17

<210>  2330
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2330
cuguccaagc ccggut                                                      16

<210>  2331
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2331
cuguccaagc ccggt                                                       15

<210>  2332
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2332
cuguccaagc ccgg                                                        14

<210>  2333
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2333
cuguccaagc ccg                                                         13

<210>  2334
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2334
cuguccaagc cc                                                          12

<210>  2335
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2335
cuguccaagc c                                                           11

<210>  2336
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2336
cuguccaagc                                                             10

<210>  2337
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2337
cuguccaag                                                              9

<210>  2338
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2338
cuguccaa                                                               8

<210>  2339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2339
guucugucca agcccgguug                                                  20

<210>  2340
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2340
guucugucca agcccggut                                                   19

<210>  2341
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2341
guucugucca agcccggt                                                    18

<210>  2342
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2342
guucugucca agcccgg                                                     17

<210>  2343
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2343
guucugucca agcccg                                                      16

<210>  2344
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2344
guucugucca agccc                                                       15

<210>  2345
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2345
guucugucca agcc                                                        14

<210>  2346
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2346
guucugucca agc                                                         13

<210>  2347
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2347
guucugucca ag                                                          12

<210>  2348
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2348
guucugucca a                                                           11

<210>  2349
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2349
guucugucca                                                             10

<210>  2350
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2350
guucugucc                                                              9

<210>  2351
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2351
guucuguc                                                               8

<210>  2352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2352
aguucugucc aagcccggut                                                  20

<210>  2353
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2353
aguucugucc aagcccggt                                                   19

<210>  2354
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2354
aguucugucc aagcccgg                                                    18

<210>  2355
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2355
aguucugucc aagcccg                                                     17

<210>  2356
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2356
aguucugucc aagccc                                                      16

<210>  2357
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2357
aguucugucc aagcc                                                       15

<210>  2358
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2358
aguucugucc aagc                                                        14

<210>  2359
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2359
aguucugucc aag                                                         13

<210>  2360
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2360
aguucugucc aa                                                          12

<210>  2361
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2361
aguucugucc a                                                           11

<210>  2362
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2362
aguucugucc                                                             10

<210>  2363
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2363
aguucuguc                                                              9

<210>  2364
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2364
aguucugt                                                               8

<210>  2365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2365
aaguucuguc caagcccggt                                                  20

<210>  2366
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2366
aaguucuguc caagcccgg                                                   19

<210>  2367
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2367
aaguucuguc caagcccg                                                    18

<210>  2368
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2368
aaguucuguc caagccc                                                     17

<210>  2369
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2369
aaguucuguc caagcc                                                      16

<210>  2370
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2370
aaguucuguc caagc                                                       15

<210>  2371
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2371
aaguucuguc caag                                                        14

<210>  2372
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2372
aaguucuguc caa                                                         13

<210>  2373
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2373
aaguucuguc ca                                                          12

<210>  2374
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2374
aaguucuguc c                                                           11

<210>  2375
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2375
aaguucuguc                                                             10

<210>  2376
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2376
aaguucugt                                                              9

<210>  2377
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2377
aaguucug                                                               8

<210>  2378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2378
taaguucugu ccaagcccgg                                                  20

<210>  2379
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2379
taaguucugu ccaagcccg                                                   19

<210>  2380
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2380
taaguucugu ccaagccc                                                    18

<210>  2381
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2381
taaguucugu ccaagcc                                                     17

<210>  2382
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2382
taaguucugu ccaagc                                                      16

<210>  2383
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2383
taaguucugu ccaa                                                        14

<210>  2384
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2384
taaguucugu cca                                                         13

<210>  2385
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2385
taaguucugu cc                                                          12

<210>  2386
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2386
taaguucugu c                                                           11

<210>  2387
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2387
taaguucugt                                                             10

<210>  2388
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2388
taaguucug                                                              9

<210>  2389
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2389
taaguuct                                                               8

<210>  2390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2390
guaaguucug uccaagcccg                                                  20

<210>  2391
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2391
guaaguucug uccaagccc                                                   19

<210>  2392
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2392
guaaguucug uccaagc                                                     17

<210>  2393
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2393
guaaguucug uccaag                                                      16

<210>  2394
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2394
guaaguucug uccaa                                                       15

<210>  2395
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2395
guaaguucug ucca                                                        14

<210>  2396
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2396
guaaguucug ucc                                                         13

<210>  2397
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2397
guaaguucug uc                                                          12

<210>  2398
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2398
guaaguucug t                                                           11

<210>  2399
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2399
guaaguucug                                                             10

<210>  2400
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2400
guaaguuct                                                              9

<210>  2401
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2401
guaaguuc                                                               8

<210>  2402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2402
gguaaguucu guccaagccc                                                  20

<210>  2403
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2403
gguaaguucu guccaagcc                                                   19

<210>  2404
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2404
gguaaguucu guccaag                                                     17

<210>  2405
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2405
gguaaguucu guccaa                                                      16

<210>  2406
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2406
gguaaguucu gucca                                                       15

<210>  2407
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2407
gguaaguucu gucc                                                        14

<210>  2408
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2408
gguaaguucu guc                                                         13

<210>  2409
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2409
gguaaguucu gt                                                          12

<210>  2410
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2410
gguaaguucu g                                                           11

<210>  2411
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2411
gguaaguuct                                                             10

<210>  2412
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2412
gguaaguuc                                                              9

<210>  2413
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2413
gguaagut                                                               8

<210>  2414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2414
cgguaaguuc uguccaagcc                                                  20

<210>  2415
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2415
cgguaaguuc uguccaagc                                                   19

<210>  2416
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2416
cgguaaguuc uguccaag                                                    18

<210>  2417
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2417
cgguaaguuc uguccaa                                                     17

<210>  2418
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2418
cgguaaguuc ugucca                                                      16

<210>  2419
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2419
cgguaaguuc ugucc                                                       15

<210>  2420
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2420
cgguaaguuc uguc                                                        14

<210>  2421
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2421
cgguaaguuc ugt                                                         13

<210>  2422
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2422
cgguaaguuc ug                                                          12

<210>  2423
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2423
cgguaaguuc t                                                           11

<210>  2424
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2424
cgguaaguuc                                                             10

<210>  2425
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2425
cgguaagut                                                              9

<210>  2426
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2426
cgguaagt                                                               8

<210>  2427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2427
tcgguaaguu cuguccaagc                                                  20

<210>  2428
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2428
tcgguaaguu cuguccaag                                                   19

<210>  2429
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2429
tcgguaaguu cuguccaa                                                    18

<210>  2430
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2430
tcgguaaguu cugucca                                                     17

<210>  2431
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2431
tcgguaaguu cugucc                                                      16

<210>  2432
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2432
tcgguaaguu cuguc                                                       15

<210>  2433
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2433
tcgguaaguu cugt                                                        14

<210>  2434
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2434
tcgguaaguu cug                                                         13

<210>  2435
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2435
tcgguaaguu ct                                                          12

<210>  2436
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2436
tcgguaaguu c                                                           11

<210>  2437
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2437
tcgguaagut                                                             10

<210>  2438
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2438
tcgguaagt                                                              9

<210>  2439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2439
gucgguaagu ucuguccaag                                                  20

<210>  2440
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2440
gucgguaagu ucuguccaa                                                   19

<210>  2441
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2441
gucgguaagu ucugucca                                                    18

<210>  2442
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2442
gucgguaagu ucugucc                                                     17

<210>  2443
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2443
gucgguaagu ucuguc                                                      16

<210>  2444
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2444
gucgguaagu ucugt                                                       15

<210>  2445
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2445
gucgguaagu ucug                                                        14

<210>  2446
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2446
gucgguaagu uct                                                         13

<210>  2447
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2447
gucgguaagu uc                                                          12

<210>  2448
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2448
gucgguaagu t                                                           11

<210>  2449
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2449
gucgguaagt                                                             10

<210>  2450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2450
agucgguaag uucuguccaa                                                  20

<210>  2451
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2451
agucgguaag uucugucca                                                   19

<210>  2452
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2452
agucgguaag uucuguc                                                     17

<210>  2453
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2453
agucgguaag uucugt                                                      16

<210>  2454
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2454
agucgguaag uucug                                                       15

<210>  2455
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2455
agucgguaag uuct                                                        14

<210>  2456
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2456
agucgguaag uuc                                                         13

<210>  2457
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2457
agucgguaag ut                                                          12

<210>  2458
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2458
agucgguaag t                                                           11

<210>  2459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2459
cagucgguaa guucugucca                                                  20

<210>  2460
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2460
cagucgguaa guucugucc                                                   19

<210>  2461
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2461
cagucgguaa guucuguc                                                    18

<210>  2462
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2462
cagucgguaa guucugt                                                     17

<210>  2463
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2463
cagucgguaa guucug                                                      16

<210>  2464
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2464
cagucgguaa guuct                                                       15

<210>  2465
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2465
cagucgguaa guuc                                                        14

<210>  2466
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2466
cagucgguaa gut                                                         13

<210>  2467
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2467
cagucgguaa gt                                                          12

<210>  2468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2468
ccagucggua aguucugucc                                                  20

<210>  2469
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2469
ccagucggua aguucuguc                                                   19

<210>  2470
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2470
ccagucggua aguucugt                                                    18

<210>  2471
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2471
ccagucggua aguucug                                                     17

<210>  2472
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2472
ccagucggua aguuct                                                      16

<210>  2473
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2473
ccagucggua aguuc                                                       15

<210>  2474
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2474
ccagucggua agut                                                        14

<210>  2475
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2475
ccagucggua agt                                                         13

<210>  2476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2476
gccagucggu aaguucuguc                                                  20

<210>  2477
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2477
gccagucggu aaguucugt                                                   19

<210>  2478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2478
gccagucggu aaguucug                                                    18

<210>  2479
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2479
gccagucggu aaguuct                                                     17

<210>  2480
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2480
gccagucggu aaguuc                                                      16

<210>  2481
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2481
gccagucggu aagut                                                       15

<210>  2482
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2482
gccagucggu aagt                                                        14

<210>  2483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2483
tcaaggaaga uggcauuuct                                                  20

<210>  2484
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2484
tcaaggaaga uggcauuucu ag                                               22

<210>  2485
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2485
tcaaggaaga uggcat                                                      16

<210>  2486
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2486
gaagauggca uuuct                                                       15

<210>  2487
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2487
tcaaggaaga uggcauuucu a                                                21

<210>  2488
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2488
tcaaggaaga uggcauuuc                                                   19

<210>  2489
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2489
tcaaggaaga uggcauut                                                    18

<210>  2490
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2490
tcaaggaaga uggcaut                                                     17

<210>  2491
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2491
tcaaggaaga uggca                                                       15

<210>  2492
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2492
tcaaggaaga uggc                                                        14

<210>  2493
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2493
tcaaggaaga ugg                                                         13

<210>  2494
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2494
tcaaggaaga ug                                                          12

<210>  2495
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2495
tcaaggaaga t                                                           11

<210>  2496
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2496
tcaaggaaga                                                             10

<210>  2497
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2497
tcaaggaag                                                              9

<210>  2498
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2498
caaggaagau ggcauuucua g                                                21

<210>  2499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2499
caaggaagau ggcauuucua                                                  20

<210>  2500
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2500
caaggaagau ggcauuuct                                                   19

<210>  2501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2501
caaggaagau ggcauuuc                                                    18

<210>  2502
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2502
caaggaagau ggcauut                                                     17

<210>  2503
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2503
caaggaagau ggcaut                                                      16

<210>  2504
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2504
caaggaagau ggcat                                                       15

<210>  2505
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2505
caaggaagau ggca                                                        14

<210>  2506
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2506
caaggaagau ggc                                                         13

<210>  2507
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2507
caaggaagau gg                                                          12

<210>  2508
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2508
caaggaagau g                                                           11

<210>  2509
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2509
caaggaagat                                                             10

<210>  2510
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2510
caaggaaga                                                              9

<210>  2511
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2511
caaggaag                                                               8

<210>  2512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2512
aaggaagaug gcauuucuag                                                  20

<210>  2513
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2513
aaggaagaug gcauuucua                                                   19

<210>  2514
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2514
aaggaagaug gcauuuct                                                    18

<210>  2515
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2515
aaggaagaug gcauuuc                                                     17

<210>  2516
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2516
aaggaagaug gcauut                                                      16

<210>  2517
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2517
aaggaagaug gcaut                                                       15

<210>  2518
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2518
aaggaagaug gcat                                                        14

<210>  2519
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2519
aaggaagaug gca                                                         13

<210>  2520
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2520
aaggaagaug gc                                                          12

<210>  2521
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2521
aaggaagaug g                                                           11

<210>  2522
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2522
aaggaagaug                                                             10

<210>  2523
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2523
aaggaagat                                                              9

<210>  2524
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2524
aaggaaga                                                               8

<210>  2525
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2525
aggaagaugg cauuucuag                                                   19

<210>  2526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2526
aggaagaugg cauuucua                                                    18

<210>  2527
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2527
aggaagaugg cauuuct                                                     17

<210>  2528
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2528
aggaagaugg cauuuc                                                      16

<210>  2529
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2529
aggaagaugg cauut                                                       15

<210>  2530
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2530
aggaagaugg caut                                                        14

<210>  2531
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2531
aggaagaugg cat                                                         13

<210>  2532
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2532
aggaagaugg ca                                                          12

<210>  2533
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2533
aggaagaugg                                                             10

<210>  2534
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2534
aggaagaug                                                              9

<210>  2535
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2535
aggaagat                                                               8

<210>  2536
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2536
ggaagauggc auuucuag                                                    18

<210>  2537
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2537
ggaagauggc auuucua                                                     17

<210>  2538
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2538
ggaagauggc auuuct                                                      16

<210>  2539
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2539
ggaagauggc auuuc                                                       15

<210>  2540
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2540
ggaagauggc auut                                                        14

<210>  2541
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2541
ggaagauggc aut                                                         13

<210>  2542
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2542
ggaagauggc at                                                          12

<210>  2543
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2543
ggaagauggc a                                                           11

<210>  2544
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2544
ggaagauggc                                                             10

<210>  2545
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2545
ggaagaug                                                               8

<210>  2546
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2546
gaagauggca uuucuag                                                     17

<210>  2547
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2547
gaagauggca uuucua                                                      16

<210>  2548
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2548
gaagauggca uuuc                                                        14

<210>  2549
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2549
gaagauggca uut                                                         13

<210>  2550
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2550
gaagauggca ut                                                          12

<210>  2551
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2551
gaagauggca t                                                           11

<210>  2552
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2552
gaagauggca                                                             10

<210>  2553
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2553
gaagauggc                                                              9

<210>  2554
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2554
gaagaugg                                                               8

<210>  2555
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2555
aagauggcau uucuag                                                      16

<210>  2556
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2556
aagauggcau uucua                                                       15

<210>  2557
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2557
aagauggcau uuct                                                        14

<210>  2558
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2558
aagauggcau uuc                                                         13

<210>  2559
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2559
aagauggcau ut                                                          12

<210>  2560
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2560
aagauggcau t                                                           11

<210>  2561
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2561
aagauggcat                                                             10

<210>  2562
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2562
aagauggca                                                              9

<210>  2563
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2563
aagauggc                                                               8

<210>  2564
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2564
agauggcauu ucuag                                                       15

<210>  2565
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2565
agauggcauu ucua                                                        14

<210>  2566
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2566
agauggcauu uct                                                         13

<210>  2567
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2567
agauggcauu uc                                                          12

<210>  2568
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2568
agauggcauu t                                                           11

<210>  2569
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2569
agauggcaut                                                             10

<210>  2570
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  2570
agauggcat                                                              9

<210>  2571
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  2571
agauggca                                                               8

<210>  2572
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  2572
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  2573
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  2573
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  2574
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  2574
cuccaacauc aaggaagaug gcauuuct                                         28

<210>  2575
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2575
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  2576
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2576
cuccaacauc aaggaagaug gcauut                                           26

<210>  2577
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2577
cuccaacauc aaggaagaug gcaut                                            25

<210>  2578
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2578
cuccaacauc aaggaagaug gcat                                             24

<210>  2579
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2579
cuccaacauc aaggaagaug gca                                              23

<210>  2580
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2580
cuccaacauc aaggaagaug gc                                               22

<210>  2581
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2581
cuccaacauc aaggaagaug g                                                21

<210>  2582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2582
cuccaacauc aaggaagaug                                                  20

<210>  2583
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2583
cuccaacauc aaggaagat                                                   19

<210>  2584
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2584
cuccaacauc aaggaaga                                                    18

<210>  2585
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2585
cuccaacauc aaggaag                                                     17

<210>  2586
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  2586
tccaacauca aggaagaugg cauuucuag                                        29

<210>  2587
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  2587
tccaacauca aggaagaugg cauuucua                                         28

<210>  2588
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2588
tccaacauca aggaagaugg cauuuct                                          27

<210>  2589
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2589
tccaacauca aggaagaugg cauuuc                                           26

<210>  2590
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2590
tccaacauca aggaagaugg cauut                                            25

<210>  2591
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2591
tccaacauca aggaagaugg caut                                             24

<210>  2592
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2592
tccaacauca aggaagaugg cat                                              23

<210>  2593
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2593
tccaacauca aggaagaugg ca                                               22

<210>  2594
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2594
tccaacauca aggaagaugg c                                                21

<210>  2595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2595
tccaacauca aggaagaugg                                                  20

<210>  2596
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2596
tccaacauca aggaagaug                                                   19

<210>  2597
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2597
tccaacauca aggaagat                                                    18

<210>  2598
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2598
tccaacauca aggaaga                                                     17

<210>  2599
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2599
tccaacauca aggaag                                                      16

<210>  2600
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  2600
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  2601
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2601
ccaacaucaa ggaagauggc auuucua                                          27

<210>  2602
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2602
ccaacaucaa ggaagauggc auuuct                                           26

<210>  2603
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2603
ccaacaucaa ggaagauggc auuuc                                            25

<210>  2604
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2604
ccaacaucaa ggaagauggc auut                                             24

<210>  2605
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2605
ccaacaucaa ggaagauggc aut                                              23

<210>  2606
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2606
ccaacaucaa ggaagauggc at                                               22

<210>  2607
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2607
ccaacaucaa ggaagauggc a                                                21

<210>  2608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2608
ccaacaucaa ggaagauggc                                                  20

<210>  2609
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2609
ccaacaucaa ggaagaugg                                                   19

<210>  2610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2610
ccaacaucaa ggaagaug                                                    18

<210>  2611
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2611
ccaacaucaa ggaagat                                                     17

<210>  2612
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2612
ccaacaucaa ggaaga                                                      16

<210>  2613
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2613
ccaacaucaa ggaag                                                       15

<210>  2614
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  2614
caacaucaag gaagauggca uuucuag                                          27

<210>  2615
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2615
caacaucaag gaagauggca uuucua                                           26

<210>  2616
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2616
caacaucaag gaagauggca uuuct                                            25

<210>  2617
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2617
caacaucaag gaagauggca uuuc                                             24

<210>  2618
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2618
caacaucaag gaagauggca uut                                              23

<210>  2619
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2619
caacaucaag gaagauggca ut                                               22

<210>  2620
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2620
caacaucaag gaagauggca t                                                21

<210>  2621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2621
caacaucaag gaagauggca                                                  20

<210>  2622
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2622
caacaucaag gaagauggc                                                   19

<210>  2623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2623
caacaucaag gaagaugg                                                    18

<210>  2624
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2624
caacaucaag gaagaug                                                     17

<210>  2625
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2625
caacaucaag gaagat                                                      16

<210>  2626
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2626
caacaucaag gaaga                                                       15

<210>  2627
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2627
caacaucaag gaag                                                        14

<210>  2628
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  2628
aacaucaagg aagauggcau uucuag                                           26

<210>  2629
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2629
aacaucaagg aagauggcau uucua                                            25

<210>  2630
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2630
aacaucaagg aagauggcau uuct                                             24

<210>  2631
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2631
aacaucaagg aagauggcau uuc                                              23

<210>  2632
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2632
aacaucaagg aagauggcau ut                                               22

<210>  2633
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2633
aacaucaagg aagauggcau t                                                21

<210>  2634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2634
aacaucaagg aagauggcat                                                  20

<210>  2635
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2635
aacaucaagg aagauggca                                                   19

<210>  2636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2636
aacaucaagg aagauggc                                                    18

<210>  2637
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2637
aacaucaagg aagaugg                                                     17

<210>  2638
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2638
aacaucaagg aagaug                                                      16

<210>  2639
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2639
aacaucaagg aagat                                                       15

<210>  2640
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2640
aacaucaagg aaga                                                        14

<210>  2641
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2641
aacaucaagg aag                                                         13

<210>  2642
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  2642
acaucaagga agauggcauu ucuag                                            25

<210>  2643
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2643
acaucaagga agauggcauu ucua                                             24

<210>  2644
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2644
acaucaagga agauggcauu uct                                              23

<210>  2645
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2645
acaucaagga agauggcauu uc                                               22

<210>  2646
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2646
acaucaagga agauggcauu t                                                21

<210>  2647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2647
acaucaagga agauggcaut                                                  20

<210>  2648
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2648
acaucaagga agauggcat                                                   19

<210>  2649
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2649
acaucaagga agauggca                                                    18

<210>  2650
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2650
acaucaagga agauggc                                                     17

<210>  2651
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2651
acaucaagga agaugg                                                      16

<210>  2652
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2652
acaucaagga agaug                                                       15

<210>  2653
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2653
acaucaagga agat                                                        14

<210>  2654
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2654
acaucaagga aga                                                         13

<210>  2655
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2655
acaucaagga ag                                                          12

<210>  2656
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  2656
caucaaggaa gauggcauuu cuag                                             24

<210>  2657
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2657
caucaaggaa gauggcauuu cua                                              23

<210>  2658
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2658
caucaaggaa gauggcauuu ct                                               22

<210>  2659
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2659
caucaaggaa gauggcauuu c                                                21

<210>  2660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2660
caucaaggaa gauggcauut                                                  20

<210>  2661
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2661
caucaaggaa gauggcaut                                                   19

<210>  2662
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2662
caucaaggaa gauggcat                                                    18

<210>  2663
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2663
caucaaggaa gauggca                                                     17

<210>  2664
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2664
caucaaggaa gauggc                                                      16

<210>  2665
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2665
caucaaggaa gaugg                                                       15

<210>  2666
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2666
caucaaggaa gaug                                                        14

<210>  2667
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2667
caucaaggaa gat                                                         13

<210>  2668
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2668
caucaaggaa ga                                                          12

<210>  2669
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2669
caucaaggaa g                                                           11

<210>  2670
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  2670
aucaaggaag auggcauuuc uag                                              23

<210>  2671
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  2671
aucaaggaag auggcauuuc ua                                               22

<210>  2672
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  2672
aucaaggaag auggcauuuc t                                                21

<210>  2673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  2673
aucaaggaag auggcauuuc                                                  20

<210>  2674
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  2674
aucaaggaag auggcauut                                                   19

<210>  2675
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  2675
aucaaggaag auggcaut                                                    18

<210>  2676
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  2676
aucaaggaag auggcat                                                     17

<210>  2677
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  2677
aucaaggaag auggca                                                      16

<210>  2678
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  2678
aucaaggaag auggc                                                       15

<210>  2679
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  2679
aucaaggaag augg                                                        14

<210>  2680
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  2680
aucaaggaag aug                                                         13

<210>  2681
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  2681
aucaaggaag at                                                          12

<210>  2682
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  2682
aucaaggaag a                                                           11

<210>  2683
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  2683
aucaaggaag                                                             10

<210>  2684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2684
gguaaguucu guccaagc                                                    18

<210>  2685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2685
gtaaguucug uccaagcc                                                    18

<210>  2686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2686
agucgguaag uucugucc                                                    18

<210>  2687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2687
ctguccaagc ccgguuga                                                    18

<210>  2688
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2688
taaguucugu ccaag                                                       15

<210>  2689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2689
ttcuguccaa gcccgguuga                                                  20

<210>  2690
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2690
ttcuguccaa gcccgguug                                                   19

<210>  2691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2691
ttcuguccaa gcccgguu                                                    18

<210>  2692
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2692
ttcuguccaa gcccggu                                                     17

<210>  2693
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2693
ttcuguccaa gcccgg                                                      16

<210>  2694
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2694
ttcuguccaa gcccg                                                       15

<210>  2695
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2695
ttcuguccaa gccc                                                        14

<210>  2696
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2696
ttcuguccaa gcc                                                         13

<210>  2697
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2697
ttcuguccaa gc                                                          12

<210>  2698
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2698
ttcuguccaa g                                                           11

<210>  2699
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2699
ttcuguccaa                                                             10

<210>  2700
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2700
ttcugucca                                                              9

<210>  2701
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2701
ttcugucc                                                               8

<210>  2702
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2702
tcuguccaag cccgguuga                                                   19

<210>  2703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2703
tcuguccaag cccgguug                                                    18

<210>  2704
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2704
tcuguccaag cccgguu                                                     17

<210>  2705
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2705
tcuguccaag cccggu                                                      16

<210>  2706
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2706
tcuguccaag cccgg                                                       15

<210>  2707
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2707
tcuguccaag cccg                                                        14

<210>  2708
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2708
tcuguccaag ccc                                                         13

<210>  2709
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2709
tcuguccaag cc                                                          12

<210>  2710
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2710
tcuguccaag c                                                           11

<210>  2711
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2711
tcuguccaag                                                             10

<210>  2712
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2712
tcuguccaa                                                              9

<210>  2713
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2713
tcugucca                                                               8

<210>  2714
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2714
ctguccaagc ccgguug                                                     17

<210>  2715
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2715
ctguccaagc ccgguu                                                      16

<210>  2716
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2716
ctguccaagc ccggu                                                       15

<210>  2717
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2717
ctguccaagc ccgg                                                        14

<210>  2718
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2718
ctguccaagc ccg                                                         13

<210>  2719
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2719
ctguccaagc cc                                                          12

<210>  2720
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2720
ctguccaagc c                                                           11

<210>  2721
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2721
ctguccaagc                                                             10

<210>  2722
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2722
ctguccaag                                                              9

<210>  2723
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2723
ctguccaa                                                               8

<210>  2724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2724
gtucugucca agcccgguug                                                  20

<210>  2725
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2725
gtucugucca agcccgguu                                                   19

<210>  2726
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2726
gtucugucca agcccggu                                                    18

<210>  2727
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2727
gtucugucca agcccgg                                                     17

<210>  2728
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2728
gtucugucca agcccg                                                      16

<210>  2729
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2729
gtucugucca agccc                                                       15

<210>  2730
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2730
gtucugucca agcc                                                        14

<210>  2731
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2731
gtucugucca agc                                                         13

<210>  2732
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2732
gtucugucca ag                                                          12

<210>  2733
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2733
gtucugucca a                                                           11

<210>  2734
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2734
gtucugucca                                                             10

<210>  2735
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2735
gtucugucc                                                              9

<210>  2736
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2736
gtucuguc                                                               8

<210>  2737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2737
aguucugucc aagcccgguu                                                  20

<210>  2738
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2738
aguucugucc aagcccggu                                                   19

<210>  2739
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2739
aguucugucc aagcccgg                                                    18

<210>  2740
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2740
aguucugucc aagcccg                                                     17

<210>  2741
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2741
aguucugucc aagccc                                                      16

<210>  2742
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2742
aguucugucc aagcc                                                       15

<210>  2743
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2743
aguucugucc aagc                                                        14

<210>  2744
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2744
aguucugucc aag                                                         13

<210>  2745
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2745
aguucugucc aa                                                          12

<210>  2746
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2746
aguucugucc a                                                           11

<210>  2747
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2747
aguucugucc                                                             10

<210>  2748
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2748
aguucuguc                                                              9

<210>  2749
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2749
aguucugu                                                               8

<210>  2750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2750
aaguucuguc caagcccggu                                                  20

<210>  2751
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2751
aaguucuguc caagcccgg                                                   19

<210>  2752
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2752
aaguucuguc caagcccg                                                    18

<210>  2753
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2753
aaguucuguc caagccc                                                     17

<210>  2754
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2754
aaguucuguc caagcc                                                      16

<210>  2755
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2755
aaguucuguc caagc                                                       15

<210>  2756
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2756
aaguucuguc caag                                                        14

<210>  2757
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2757
aaguucuguc caa                                                         13

<210>  2758
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2758
aaguucuguc ca                                                          12

<210>  2759
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2759
aaguucuguc c                                                           11

<210>  2760
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2760
aaguucuguc                                                             10

<210>  2761
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2761
aaguucugu                                                              9

<210>  2762
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2762
aaguucug                                                               8

<210>  2763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2763
taaguucugu ccaagcccgg                                                  20

<210>  2764
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2764
taaguucugu ccaagcccg                                                   19

<210>  2765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2765
taaguucugu ccaagccc                                                    18

<210>  2766
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2766
taaguucugu ccaagcc                                                     17

<210>  2767
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2767
taaguucugu ccaagc                                                      16

<210>  2768
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2768
taaguucugu ccaa                                                        14

<210>  2769
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2769
taaguucugu cca                                                         13

<210>  2770
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2770
taaguucugu cc                                                          12

<210>  2771
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2771
taaguucugu c                                                           11

<210>  2772
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2772
taaguucugu                                                             10

<210>  2773
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2773
taaguucug                                                              9

<210>  2774
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2774
taaguucu                                                               8

<210>  2775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2775
gtaaguucug uccaagcccg                                                  20

<210>  2776
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2776
gtaaguucug uccaagccc                                                   19

<210>  2777
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2777
gtaaguucug uccaagc                                                     17

<210>  2778
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2778
gtaaguucug uccaag                                                      16

<210>  2779
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2779
gtaaguucug uccaa                                                       15

<210>  2780
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2780
gtaaguucug ucca                                                        14

<210>  2781
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2781
gtaaguucug ucc                                                         13

<210>  2782
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2782
gtaaguucug uc                                                          12

<210>  2783
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2783
gtaaguucug u                                                           11

<210>  2784
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2784
gtaaguucug                                                             10

<210>  2785
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2785
gtaaguucu                                                              9

<210>  2786
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2786
gtaaguuc                                                               8

<210>  2787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2787
gguaaguucu guccaagccc                                                  20

<210>  2788
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2788
gguaaguucu guccaagcc                                                   19

<210>  2789
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2789
gguaaguucu guccaag                                                     17

<210>  2790
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2790
gguaaguucu guccaa                                                      16

<210>  2791
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2791
gguaaguucu gucca                                                       15

<210>  2792
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2792
gguaaguucu gucc                                                        14

<210>  2793
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2793
gguaaguucu guc                                                         13

<210>  2794
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2794
gguaaguucu gu                                                          12

<210>  2795
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2795
gguaaguucu g                                                           11

<210>  2796
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2796
gguaaguucu                                                             10

<210>  2797
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2797
gguaaguuc                                                              9

<210>  2798
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2798
gguaaguu                                                               8

<210>  2799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2799
cgguaaguuc uguccaagcc                                                  20

<210>  2800
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2800
cgguaaguuc uguccaagc                                                   19

<210>  2801
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2801
cgguaaguuc uguccaag                                                    18

<210>  2802
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2802
cgguaaguuc uguccaa                                                     17

<210>  2803
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2803
cgguaaguuc ugucca                                                      16

<210>  2804
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2804
cgguaaguuc ugucc                                                       15

<210>  2805
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2805
cgguaaguuc uguc                                                        14

<210>  2806
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2806
cgguaaguuc ugu                                                         13

<210>  2807
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2807
cgguaaguuc ug                                                          12

<210>  2808
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2808
cgguaaguuc u                                                           11

<210>  2809
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2809
cgguaaguuc                                                             10

<210>  2810
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2810
cgguaaguu                                                              9

<210>  2811
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2811
cgguaagu                                                               8

<210>  2812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2812
tcgguaaguu cuguccaagc                                                  20

<210>  2813
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2813
tcgguaaguu cuguccaag                                                   19

<210>  2814
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2814
tcgguaaguu cuguccaa                                                    18

<210>  2815
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2815
tcgguaaguu cugucca                                                     17

<210>  2816
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2816
tcgguaaguu cugucc                                                      16

<210>  2817
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2817
tcgguaaguu cuguc                                                       15

<210>  2818
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2818
tcgguaaguu cugu                                                        14

<210>  2819
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2819
tcgguaaguu cug                                                         13

<210>  2820
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2820
tcgguaaguu cu                                                          12

<210>  2821
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2821
tcgguaaguu c                                                           11

<210>  2822
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2822
tcgguaaguu                                                             10

<210>  2823
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2823
tcgguaagu                                                              9

<210>  2824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2824
gtcgguaagu ucuguccaag                                                  20

<210>  2825
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2825
gtcgguaagu ucuguccaa                                                   19

<210>  2826
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2826
gtcgguaagu ucugucca                                                    18

<210>  2827
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2827
gtcgguaagu ucugucc                                                     17

<210>  2828
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2828
gtcgguaagu ucuguc                                                      16

<210>  2829
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2829
gtcgguaagu ucugu                                                       15

<210>  2830
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2830
gtcgguaagu ucug                                                        14

<210>  2831
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2831
gtcgguaagu ucu                                                         13

<210>  2832
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2832
gtcgguaagu uc                                                          12

<210>  2833
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2833
gtcgguaagu u                                                           11

<210>  2834
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2834
gtcgguaagu                                                             10

<210>  2835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2835
agucgguaag uucuguccaa                                                  20

<210>  2836
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2836
agucgguaag uucugucca                                                   19

<210>  2837
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2837
agucgguaag uucuguc                                                     17

<210>  2838
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2838
agucgguaag uucugu                                                      16

<210>  2839
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2839
agucgguaag uucug                                                       15

<210>  2840
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2840
agucgguaag uucu                                                        14

<210>  2841
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2841
agucgguaag uuc                                                         13

<210>  2842
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2842
agucgguaag uu                                                          12

<210>  2843
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2843
agucgguaag u                                                           11

<210>  2844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2844
cagucgguaa guucugucca                                                  20

<210>  2845
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2845
cagucgguaa guucugucc                                                   19

<210>  2846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2846
cagucgguaa guucuguc                                                    18

<210>  2847
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2847
cagucgguaa guucugu                                                     17

<210>  2848
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2848
cagucgguaa guucug                                                      16

<210>  2849
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2849
cagucgguaa guucu                                                       15

<210>  2850
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2850
cagucgguaa guuc                                                        14

<210>  2851
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2851
cagucgguaa guu                                                         13

<210>  2852
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2852
cagucgguaa gu                                                          12

<210>  2853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2853
ccagucggua aguucugucc                                                  20

<210>  2854
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2854
ccagucggua aguucuguc                                                   19

<210>  2855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2855
ccagucggua aguucugu                                                    18

<210>  2856
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2856
ccagucggua aguucug                                                     17

<210>  2857
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2857
ccagucggua aguucu                                                      16

<210>  2858
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2858
ccagucggua aguuc                                                       15

<210>  2859
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2859
ccagucggua aguu                                                        14

<210>  2860
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2860
ccagucggua agu                                                         13

<210>  2861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2861
gccagucggu aaguucuguc                                                  20

<210>  2862
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2862
gccagucggu aaguucugu                                                   19

<210>  2863
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2863
gccagucggu aaguucug                                                    18

<210>  2864
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2864
gccagucggu aaguucu                                                     17

<210>  2865
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2865
gccagucggu aaguuc                                                      16

<210>  2866
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2866
gccagucggu aaguu                                                       15

<210>  2867
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2867
gccagucggu aagu                                                        14

<210>  2868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2868
tcaaggaaga uggcauuucu                                                  20

<210>  2869
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2869
tcaaggaaga uggcauuucu ag                                               22

<210>  2870
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2870
tcaaggaaga uggcau                                                      16

<210>  2871
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2871
gaagauggca uuucu                                                       15

<210>  2872
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2872
tcaaggaaga uggcauuucu a                                                21

<210>  2873
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2873
tcaaggaaga uggcauuuc                                                   19

<210>  2874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2874
tcaaggaaga uggcauuu                                                    18

<210>  2875
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2875
tcaaggaaga uggcauu                                                     17

<210>  2876
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2876
tcaaggaaga uggca                                                       15

<210>  2877
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2877
tcaaggaaga uggc                                                        14

<210>  2878
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2878
tcaaggaaga ugg                                                         13

<210>  2879
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2879
tcaaggaaga ug                                                          12

<210>  2880
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2880
tcaaggaaga u                                                           11

<210>  2881
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2881
tcaaggaaga                                                             10

<210>  2882
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2882
tcaaggaag                                                              9

<210>  2883
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2883
caaggaagau ggcauuucua g                                                21

<210>  2884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2884
caaggaagau ggcauuucua                                                  20

<210>  2885
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2885
caaggaagau ggcauuucu                                                   19

<210>  2886
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2886
caaggaagau ggcauuuc                                                    18

<210>  2887
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2887
caaggaagau ggcauuu                                                     17

<210>  2888
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2888
caaggaagau ggcauu                                                      16

<210>  2889
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2889
caaggaagau ggcau                                                       15

<210>  2890
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2890
caaggaagau ggca                                                        14

<210>  2891
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2891
caaggaagau ggc                                                         13

<210>  2892
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2892
caaggaagau gg                                                          12

<210>  2893
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2893
caaggaagau g                                                           11

<210>  2894
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2894
caaggaagau                                                             10

<210>  2895
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2895
caaggaaga                                                              9

<210>  2896
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2896
caaggaag                                                               8

<210>  2897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2897
aaggaagaug gcauuucuag                                                  20

<210>  2898
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2898
aaggaagaug gcauuucua                                                   19

<210>  2899
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2899
aaggaagaug gcauuucu                                                    18

<210>  2900
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2900
aaggaagaug gcauuuc                                                     17

<210>  2901
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2901
aaggaagaug gcauuu                                                      16

<210>  2902
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2902
aaggaagaug gcauu                                                       15

<210>  2903
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2903
aaggaagaug gcau                                                        14

<210>  2904
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2904
aaggaagaug gca                                                         13

<210>  2905
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2905
aaggaagaug gc                                                          12

<210>  2906
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2906
aaggaagaug g                                                           11

<210>  2907
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2907
aaggaagaug                                                             10

<210>  2908
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2908
aaggaagau                                                              9

<210>  2909
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2909
aaggaaga                                                               8

<210>  2910
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2910
aggaagaugg cauuucuag                                                   19

<210>  2911
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2911
aggaagaugg cauuucua                                                    18

<210>  2912
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2912
aggaagaugg cauuucu                                                     17

<210>  2913
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2913
aggaagaugg cauuuc                                                      16

<210>  2914
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2914
aggaagaugg cauuu                                                       15

<210>  2915
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2915
aggaagaugg cauu                                                        14

<210>  2916
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2916
aggaagaugg cau                                                         13

<210>  2917
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2917
aggaagaugg ca                                                          12

<210>  2918
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2918
aggaagaugg                                                             10

<210>  2919
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2919
aggaagaug                                                              9

<210>  2920
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2920
aggaagau                                                               8

<210>  2921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2921
ggaagauggc auuucuag                                                    18

<210>  2922
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2922
ggaagauggc auuucua                                                     17

<210>  2923
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2923
ggaagauggc auuucu                                                      16

<210>  2924
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2924
ggaagauggc auuuc                                                       15

<210>  2925
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2925
ggaagauggc auuu                                                        14

<210>  2926
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2926
ggaagauggc auu                                                         13

<210>  2927
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2927
ggaagauggc au                                                          12

<210>  2928
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2928
ggaagauggc a                                                           11

<210>  2929
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2929
ggaagauggc                                                             10

<210>  2930
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2930
ggaagaug                                                               8

<210>  2931
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2931
gaagauggca uuucuag                                                     17

<210>  2932
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2932
gaagauggca uuucua                                                      16

<210>  2933
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2933
gaagauggca uuuc                                                        14

<210>  2934
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2934
gaagauggca uuu                                                         13

<210>  2935
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2935
gaagauggca uu                                                          12

<210>  2936
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2936
gaagauggca u                                                           11

<210>  2937
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2937
gaagauggca                                                             10

<210>  2938
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2938
gaagauggc                                                              9

<210>  2939
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2939
gaagaugg                                                               8

<210>  2940
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2940
aagauggcau uucuag                                                      16

<210>  2941
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2941
aagauggcau uucua                                                       15

<210>  2942
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2942
aagauggcau uucu                                                        14

<210>  2943
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2943
aagauggcau uuc                                                         13

<210>  2944
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2944
aagauggcau uu                                                          12

<210>  2945
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2945
aagauggcau u                                                           11

<210>  2946
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2946
aagauggcau                                                             10

<210>  2947
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2947
aagauggca                                                              9

<210>  2948
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2948
aagauggc                                                               8

<210>  2949
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2949
agauggcauu ucuag                                                       15

<210>  2950
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2950
agauggcauu ucua                                                        14

<210>  2951
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2951
agauggcauu ucu                                                         13

<210>  2952
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2952
agauggcauu uc                                                          12

<210>  2953
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2953
agauggcauu u                                                           11

<210>  2954
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2954
agauggcauu                                                             10

<210>  2955
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2955
agauggcau                                                              9

<210>  2956
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2956
agauggca                                                               8

<210>  2957
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2957
ctccaacauc aaggaagaug gcauuucuag                                       30

<210>  2958
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2958
ctccaacauc aaggaagaug gcauuucua                                        29

<210>  2959
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2959
ctccaacauc aaggaagaug gcauuucu                                         28

<210>  2960
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2960
ctccaacauc aaggaagaug gcauuuc                                          27

<210>  2961
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2961
ctccaacauc aaggaagaug gcauuu                                           26

<210>  2962
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2962
ctccaacauc aaggaagaug gcauu                                            25

<210>  2963
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2963
ctccaacauc aaggaagaug gcau                                             24

<210>  2964
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2964
ctccaacauc aaggaagaug gca                                              23

<210>  2965
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2965
ctccaacauc aaggaagaug gc                                               22

<210>  2966
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2966
ctccaacauc aaggaagaug g                                                21

<210>  2967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2967
ctccaacauc aaggaagaug                                                  20

<210>  2968
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2968
ctccaacauc aaggaagau                                                   19

<210>  2969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2969
ctccaacauc aaggaaga                                                    18

<210>  2970
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2970
ctccaacauc aaggaag                                                     17

<210>  2971
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2971
tccaacauca aggaagaugg cauuucuag                                        29

<210>  2972
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2972
tccaacauca aggaagaugg cauuucua                                         28

<210>  2973
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2973
tccaacauca aggaagaugg cauuucu                                          27

<210>  2974
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2974
tccaacauca aggaagaugg cauuuc                                           26

<210>  2975
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2975
tccaacauca aggaagaugg cauuu                                            25

<210>  2976
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2976
tccaacauca aggaagaugg cauu                                             24

<210>  2977
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2977
tccaacauca aggaagaugg cau                                              23

<210>  2978
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2978
tccaacauca aggaagaugg ca                                               22

<210>  2979
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2979
tccaacauca aggaagaugg c                                                21

<210>  2980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2980
tccaacauca aggaagaugg                                                  20

<210>  2981
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2981
tccaacauca aggaagaug                                                   19

<210>  2982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2982
tccaacauca aggaagau                                                    18

<210>  2983
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2983
tccaacauca aggaaga                                                     17

<210>  2984
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2984
tccaacauca aggaag                                                      16

<210>  2985
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2985
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  2986
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2986
ccaacaucaa ggaagauggc auuucua                                          27

<210>  2987
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2987
ccaacaucaa ggaagauggc auuucu                                           26

<210>  2988
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2988
ccaacaucaa ggaagauggc auuuc                                            25

<210>  2989
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2989
ccaacaucaa ggaagauggc auuu                                             24

<210>  2990
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2990
ccaacaucaa ggaagauggc auu                                              23

<210>  2991
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2991
ccaacaucaa ggaagauggc au                                               22

<210>  2992
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2992
ccaacaucaa ggaagauggc a                                                21

<210>  2993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2993
ccaacaucaa ggaagauggc                                                  20

<210>  2994
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2994
ccaacaucaa ggaagaugg                                                   19

<210>  2995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2995
ccaacaucaa ggaagaug                                                    18

<210>  2996
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2996
ccaacaucaa ggaagau                                                     17

<210>  2997
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2997
ccaacaucaa ggaaga                                                      16

<210>  2998
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2998
ccaacaucaa ggaag                                                       15

<210>  2999
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  2999
caacaucaag gaagauggca uuucuag                                          27

<210>  3000
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3000
caacaucaag gaagauggca uuucua                                           26

<210>  3001
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3001
caacaucaag gaagauggca uuucu                                            25

<210>  3002
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3002
caacaucaag gaagauggca uuuc                                             24

<210>  3003
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3003
caacaucaag gaagauggca uuu                                              23

<210>  3004
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3004
caacaucaag gaagauggca uu                                               22

<210>  3005
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3005
caacaucaag gaagauggca u                                                21

<210>  3006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3006
caacaucaag gaagauggca                                                  20

<210>  3007
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3007
caacaucaag gaagauggc                                                   19

<210>  3008
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3008
caacaucaag gaagaugg                                                    18

<210>  3009
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3009
caacaucaag gaagaug                                                     17

<210>  3010
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3010
caacaucaag gaagau                                                      16

<210>  3011
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3011
caacaucaag gaaga                                                       15

<210>  3012
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3012
caacaucaag gaag                                                        14

<210>  3013
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3013
aacaucaagg aagauggcau uucuag                                           26

<210>  3014
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3014
aacaucaagg aagauggcau uucua                                            25

<210>  3015
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3015
aacaucaagg aagauggcau uucu                                             24

<210>  3016
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3016
aacaucaagg aagauggcau uuc                                              23

<210>  3017
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3017
aacaucaagg aagauggcau uu                                               22

<210>  3018
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3018
aacaucaagg aagauggcau u                                                21

<210>  3019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3019
aacaucaagg aagauggcau                                                  20

<210>  3020
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3020
aacaucaagg aagauggca                                                   19

<210>  3021
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3021
aacaucaagg aagauggc                                                    18

<210>  3022
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3022
aacaucaagg aagaugg                                                     17

<210>  3023
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3023
aacaucaagg aagaug                                                      16

<210>  3024
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3024
aacaucaagg aagau                                                       15

<210>  3025
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3025
aacaucaagg aaga                                                        14

<210>  3026
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3026
aacaucaagg aag                                                         13

<210>  3027
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3027
acaucaagga agauggcauu ucuag                                            25

<210>  3028
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3028
acaucaagga agauggcauu ucua                                             24

<210>  3029
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3029
acaucaagga agauggcauu ucu                                              23

<210>  3030
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3030
acaucaagga agauggcauu uc                                               22

<210>  3031
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3031
acaucaagga agauggcauu u                                                21

<210>  3032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3032
acaucaagga agauggcauu                                                  20

<210>  3033
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3033
acaucaagga agauggcau                                                   19

<210>  3034
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3034
acaucaagga agauggca                                                    18

<210>  3035
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3035
acaucaagga agauggc                                                     17

<210>  3036
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3036
acaucaagga agaugg                                                      16

<210>  3037
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3037
acaucaagga agaug                                                       15

<210>  3038
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3038
acaucaagga agau                                                        14

<210>  3039
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3039
acaucaagga aga                                                         13

<210>  3040
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3040
acaucaagga ag                                                          12

<210>  3041
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3041
caucaaggaa gauggcauuu cuag                                             24

<210>  3042
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3042
caucaaggaa gauggcauuu cua                                              23

<210>  3043
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3043
caucaaggaa gauggcauuu cu                                               22

<210>  3044
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3044
caucaaggaa gauggcauuu c                                                21

<210>  3045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3045
caucaaggaa gauggcauuu                                                  20

<210>  3046
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3046
caucaaggaa gauggcauu                                                   19

<210>  3047
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3047
caucaaggaa gauggcau                                                    18

<210>  3048
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3048
caucaaggaa gauggca                                                     17

<210>  3049
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3049
caucaaggaa gauggc                                                      16

<210>  3050
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3050
caucaaggaa gaugg                                                       15

<210>  3051
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3051
caucaaggaa gaug                                                        14

<210>  3052
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3052
caucaaggaa gau                                                         13

<210>  3053
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3053
caucaaggaa ga                                                          12

<210>  3054
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3054
caucaaggaa g                                                           11

<210>  3055
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3055
atcaaggaag auggcauuuc uag                                              23

<210>  3056
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3056
atcaaggaag auggcauuuc ua                                               22

<210>  3057
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3057
atcaaggaag auggcauuuc u                                                21

<210>  3058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3058
atcaaggaag auggcauuuc                                                  20

<210>  3059
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3059
atcaaggaag auggcauuu                                                   19

<210>  3060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3060
atcaaggaag auggcauu                                                    18

<210>  3061
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3061
atcaaggaag auggcau                                                     17

<210>  3062
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3062
atcaaggaag auggca                                                      16

<210>  3063
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3063
atcaaggaag auggc                                                       15

<210>  3064
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3064
atcaaggaag augg                                                        14

<210>  3065
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3065
atcaaggaag aug                                                         13

<210>  3066
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3066
atcaaggaag au                                                          12

<210>  3067
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3067
atcaaggaag a                                                           11

<210>  3068
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  3068
atcaaggaag                                                             10

<210>  3069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3069
gguaaguucu guccaagc                                                    18

<210>  3070
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3070
guaaguucug uccaagcc                                                    18

<210>  3071
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3071
agucgguaag uucugucc                                                    18

<210>  3072
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3072
cuguccaagc ccgguuga                                                    18

<210>  3073
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3073
uaaguucugu ccaag                                                       15

<210>  3074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3074
uucuguccaa gcccgguuga                                                  20

<210>  3075
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3075
uucuguccaa gcccggutg                                                   19

<210>  3076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3076
uucuguccaa gcccggtt                                                    18

<210>  3077
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3077
uucuguccaa gcccggt                                                     17

<210>  3078
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3078
uucuguccaa gcccgg                                                      16

<210>  3079
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3079
uucuguccaa gcccg                                                       15

<210>  3080
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3080
uucuguccaa gccc                                                        14

<210>  3081
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3081
uucuguccaa gcc                                                         13

<210>  3082
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3082
uucuguccaa gc                                                          12

<210>  3083
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3083
uucuguccaa g                                                           11

<210>  3084
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3084
uucuguccaa                                                             10

<210>  3085
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3085
uucugucca                                                              9

<210>  3086
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3086
uucugucc                                                               8

<210>  3087
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3087
ucuguccaag cccgguuga                                                   19

<210>  3088
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3088
ucuguccaag cccggutg                                                    18

<210>  3089
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3089
ucuguccaag cccggtt                                                     17

<210>  3090
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3090
ucuguccaag cccggt                                                      16

<210>  3091
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3091
ucuguccaag cccgg                                                       15

<210>  3092
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3092
ucuguccaag cccg                                                        14

<210>  3093
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3093
ucuguccaag ccc                                                         13

<210>  3094
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3094
ucuguccaag cc                                                          12

<210>  3095
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3095
ucuguccaag c                                                           11

<210>  3096
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3096
ucuguccaag                                                             10

<210>  3097
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3097
ucuguccaa                                                              9

<210>  3098
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3098
ucugucca                                                               8

<210>  3099
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3099
cuguccaagc ccggutg                                                     17

<210>  3100
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3100
cuguccaagc ccggtt                                                      16

<210>  3101
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3101
cuguccaagc ccggt                                                       15

<210>  3102
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3102
cuguccaagc ccgg                                                        14

<210>  3103
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3103
cuguccaagc ccg                                                         13

<210>  3104
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3104
cuguccaagc cc                                                          12

<210>  3105
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3105
cuguccaagc c                                                           11

<210>  3106
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3106
cuguccaagc                                                             10

<210>  3107
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3107
cuguccaag                                                              9

<210>  3108
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3108
cuguccaa                                                               8

<210>  3109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3109
guucugucca agcccggutg                                                  20

<210>  3110
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3110
guucugucca agcccggtt                                                   19

<210>  3111
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3111
guucugucca agcccggt                                                    18

<210>  3112
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3112
guucugucca agcccgg                                                     17

<210>  3113
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3113
guucugucca agcccg                                                      16

<210>  3114
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3114
guucugucca agccc                                                       15

<210>  3115
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3115
guucugucca agcc                                                        14

<210>  3116
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3116
guucugucca agc                                                         13

<210>  3117
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3117
guucugucca ag                                                          12

<210>  3118
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3118
guucugucca a                                                           11

<210>  3119
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3119
guucugucca                                                             10

<210>  3120
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3120
guucugucc                                                              9

<210>  3121
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3121
guucugtc                                                               8

<210>  3122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3122
aguucugucc aagcccggtt                                                  20

<210>  3123
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3123
aguucugucc aagcccggt                                                   19

<210>  3124
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3124
aguucugucc aagcccgg                                                    18

<210>  3125
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3125
aguucugucc aagcccg                                                     17

<210>  3126
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3126
aguucugucc aagccc                                                      16

<210>  3127
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3127
aguucugucc aagcc                                                       15

<210>  3128
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3128
aguucugucc aagc                                                        14

<210>  3129
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3129
aguucugucc aag                                                         13

<210>  3130
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3130
aguucugucc aa                                                          12

<210>  3131
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3131
aguucugucc a                                                           11

<210>  3132
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3132
aguucugucc                                                             10

<210>  3133
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3133
aguucugtc                                                              9

<210>  3134
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3134
aguucugt                                                               8

<210>  3135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3135
aaguucuguc caagcccggt                                                  20

<210>  3136
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3136
aaguucuguc caagcccgg                                                   19

<210>  3137
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3137
aaguucuguc caagcccg                                                    18

<210>  3138
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3138
aaguucuguc caagccc                                                     17

<210>  3139
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3139
aaguucuguc caagcc                                                      16

<210>  3140
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3140
aaguucuguc caagc                                                       15

<210>  3141
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3141
aaguucuguc caag                                                        14

<210>  3142
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3142
aaguucuguc caa                                                         13

<210>  3143
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3143
aaguucuguc ca                                                          12

<210>  3144
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3144
aaguucuguc c                                                           11

<210>  3145
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3145
aaguucugtc                                                             10

<210>  3146
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3146
aaguucugt                                                              9

<210>  3147
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3147
aaguuctg                                                               8

<210>  3148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3148
uaaguucugu ccaagcccgg                                                  20

<210>  3149
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3149
uaaguucugu ccaagcccg                                                   19

<210>  3150
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3150
uaaguucugu ccaagccc                                                    18

<210>  3151
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3151
uaaguucugu ccaagcc                                                     17

<210>  3152
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3152
uaaguucugu ccaagc                                                      16

<210>  3153
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3153
uaaguucugu ccaa                                                        14

<210>  3154
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3154
uaaguucugu cca                                                         13

<210>  3155
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3155
uaaguucugu cc                                                          12

<210>  3156
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3156
uaaguucugt c                                                           11

<210>  3157
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3157
uaaguucugt                                                             10

<210>  3158
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3158
uaaguuctg                                                              9

<210>  3159
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3159
uaaguuct                                                               8

<210>  3160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3160
guaaguucug uccaagcccg                                                  20

<210>  3161
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3161
guaaguucug uccaagccc                                                   19

<210>  3162
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3162
guaaguucug uccaagc                                                     17

<210>  3163
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3163
guaaguucug uccaag                                                      16

<210>  3164
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3164
guaaguucug uccaa                                                       15

<210>  3165
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3165
guaaguucug ucca                                                        14

<210>  3166
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3166
guaaguucug ucc                                                         13

<210>  3167
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3167
guaaguucug tc                                                          12

<210>  3168
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3168
guaaguucug t                                                           11

<210>  3169
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3169
guaaguuctg                                                             10

<210>  3170
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3170
guaaguuct                                                              9

<210>  3171
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3171
guaagutc                                                               8

<210>  3172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3172
gguaaguucu guccaagccc                                                  20

<210>  3173
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3173
gguaaguucu guccaagcc                                                   19

<210>  3174
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3174
gguaaguucu guccaag                                                     17

<210>  3175
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3175
gguaaguucu guccaa                                                      16

<210>  3176
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3176
gguaaguucu gucca                                                       15

<210>  3177
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3177
gguaaguucu gucc                                                        14

<210>  3178
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3178
gguaaguucu gtc                                                         13

<210>  3179
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3179
gguaaguucu gt                                                          12

<210>  3180
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3180
gguaaguuct g                                                           11

<210>  3181
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3181
gguaaguuct                                                             10

<210>  3182
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3182
gguaagutc                                                              9

<210>  3183
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3183
gguaagtt                                                               8

<210>  3184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3184
cgguaaguuc uguccaagcc                                                  20

<210>  3185
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3185
cgguaaguuc uguccaagc                                                   19

<210>  3186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3186
cgguaaguuc uguccaag                                                    18

<210>  3187
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3187
cgguaaguuc uguccaa                                                     17

<210>  3188
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3188
cgguaaguuc ugucca                                                      16

<210>  3189
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3189
cgguaaguuc ugucc                                                       15

<210>  3190
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3190
cgguaaguuc ugtc                                                        14

<210>  3191
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3191
cgguaaguuc ugt                                                         13

<210>  3192
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3192
cgguaaguuc tg                                                          12

<210>  3193
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3193
cgguaaguuc t                                                           11

<210>  3194
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3194
cgguaagutc                                                             10

<210>  3195
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3195
cgguaagtt                                                              9

<210>  3196
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3196
cgguaagt                                                               8

<210>  3197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3197
ucgguaaguu cuguccaagc                                                  20

<210>  3198
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3198
ucgguaaguu cuguccaag                                                   19

<210>  3199
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3199
ucgguaaguu cuguccaa                                                    18

<210>  3200
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3200
ucgguaaguu cugucca                                                     17

<210>  3201
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3201
ucgguaaguu cugucc                                                      16

<210>  3202
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3202
ucgguaaguu cugtc                                                       15

<210>  3203
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3203
ucgguaaguu cugt                                                        14

<210>  3204
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3204
ucgguaaguu ctg                                                         13

<210>  3205
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3205
ucgguaaguu ct                                                          12

<210>  3206
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3206
ucgguaagut c                                                           11

<210>  3207
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3207
ucgguaagtt                                                             10

<210>  3208
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3208
ucgguaagt                                                              9

<210>  3209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3209
gucgguaagu ucuguccaag                                                  20

<210>  3210
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3210
gucgguaagu ucuguccaa                                                   19

<210>  3211
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3211
gucgguaagu ucugucca                                                    18

<210>  3212
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3212
gucgguaagu ucugucc                                                     17

<210>  3213
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3213
gucgguaagu ucugtc                                                      16

<210>  3214
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3214
gucgguaagu ucugt                                                       15

<210>  3215
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3215
gucgguaagu uctg                                                        14

<210>  3216
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3216
gucgguaagu uct                                                         13

<210>  3217
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3217
gucgguaagu tc                                                          12

<210>  3218
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3218
gucgguaagt t                                                           11

<210>  3219
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3219
gucgguaagt                                                             10

<210>  3220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3220
agucgguaag uucuguccaa                                                  20

<210>  3221
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3221
agucgguaag uucugucca                                                   19

<210>  3222
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3222
agucgguaag uucugtc                                                     17

<210>  3223
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3223
agucgguaag uucugt                                                      16

<210>  3224
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3224
agucgguaag uuctg                                                       15

<210>  3225
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3225
agucgguaag uuct                                                        14

<210>  3226
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3226
agucgguaag utc                                                         13

<210>  3227
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3227
agucgguaag tt                                                          12

<210>  3228
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3228
agucgguaag t                                                           11

<210>  3229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3229
cagucgguaa guucugucca                                                  20

<210>  3230
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3230
cagucgguaa guucugucc                                                   19

<210>  3231
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3231
cagucgguaa guucugtc                                                    18

<210>  3232
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3232
cagucgguaa guucugt                                                     17

<210>  3233
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3233
cagucgguaa guuctg                                                      16

<210>  3234
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3234
cagucgguaa guuct                                                       15

<210>  3235
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3235
cagucgguaa gutc                                                        14

<210>  3236
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3236
cagucgguaa gtt                                                         13

<210>  3237
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3237
cagucgguaa gt                                                          12

<210>  3238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3238
ccagucggua aguucugucc                                                  20

<210>  3239
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3239
ccagucggua aguucugtc                                                   19

<210>  3240
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3240
ccagucggua aguucugt                                                    18

<210>  3241
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3241
ccagucggua aguuctg                                                     17

<210>  3242
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3242
ccagucggua aguuct                                                      16

<210>  3243
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3243
ccagucggua agutc                                                       15

<210>  3244
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3244
ccagucggua agtt                                                        14

<210>  3245
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3245
ccagucggua agt                                                         13

<210>  3246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3246
gccagucggu aaguucugtc                                                  20

<210>  3247
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3247
gccagucggu aaguucugt                                                   19

<210>  3248
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3248
gccagucggu aaguuctg                                                    18

<210>  3249
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3249
gccagucggu aaguuct                                                     17

<210>  3250
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3250
gccagucggu aagutc                                                      16

<210>  3251
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3251
gccagucggu aagtt                                                       15

<210>  3252
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3252
gccagucggu aagt                                                        14

<210>  3253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3253
ucaaggaaga uggcauuuct                                                  20

<210>  3254
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3254
ucaaggaaga uggcauuucu ag                                               22

<210>  3255
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3255
ucaaggaaga uggcat                                                      16

<210>  3256
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3256
gaagauggca uuuct                                                       15

<210>  3257
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3257
ucaaggaaga uggcauuuct a                                                21

<210>  3258
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3258
ucaaggaaga uggcauutc                                                   19

<210>  3259
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3259
ucaaggaaga uggcautt                                                    18

<210>  3260
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3260
ucaaggaaga uggcatt                                                     17

<210>  3261
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3261
ucaaggaaga uggca                                                       15

<210>  3262
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3262
ucaaggaaga uggc                                                        14

<210>  3263
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3263
ucaaggaaga ugg                                                         13

<210>  3264
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3264
ucaaggaaga tg                                                          12

<210>  3265
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3265
ucaaggaaga t                                                           11

<210>  3266
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3266
ucaaggaaga                                                             10

<210>  3267
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3267
ucaaggaag                                                              9

<210>  3268
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3268
caaggaagau ggcauuucua g                                                21

<210>  3269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3269
caaggaagau ggcauuucta                                                  20

<210>  3270
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3270
caaggaagau ggcauuuct                                                   19

<210>  3271
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3271
caaggaagau ggcauutc                                                    18

<210>  3272
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3272
caaggaagau ggcautt                                                     17

<210>  3273
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3273
caaggaagau ggcatt                                                      16

<210>  3274
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3274
caaggaagau ggcat                                                       15

<210>  3275
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3275
caaggaagau ggca                                                        14

<210>  3276
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3276
caaggaagau ggc                                                         13

<210>  3277
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3277
caaggaagau gg                                                          12

<210>  3278
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3278
caaggaagat g                                                           11

<210>  3279
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3279
caaggaagat                                                             10

<210>  3280
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3280
caaggaaga                                                              9

<210>  3281
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3281
caaggaag                                                               8

<210>  3282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3282
aaggaagaug gcauuucuag                                                  20

<210>  3283
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3283
aaggaagaug gcauuucta                                                   19

<210>  3284
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3284
aaggaagaug gcauuuct                                                    18

<210>  3285
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3285
aaggaagaug gcauutc                                                     17

<210>  3286
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3286
aaggaagaug gcautt                                                      16

<210>  3287
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3287
aaggaagaug gcatt                                                       15

<210>  3288
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3288
aaggaagaug gcat                                                        14

<210>  3289
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3289
aaggaagaug gca                                                         13

<210>  3290
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3290
aaggaagaug gc                                                          12

<210>  3291
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3291
aaggaagaug g                                                           11

<210>  3292
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3292
aaggaagatg                                                             10

<210>  3293
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3293
aaggaagat                                                              9

<210>  3294
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3294
aaggaaga                                                               8

<210>  3295
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3295
aggaagaugg cauuucuag                                                   19

<210>  3296
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3296
aggaagaugg cauuucta                                                    18

<210>  3297
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3297
aggaagaugg cauuuct                                                     17

<210>  3298
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3298
aggaagaugg cauutc                                                      16

<210>  3299
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3299
aggaagaugg cautt                                                       15

<210>  3300
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3300
aggaagaugg catt                                                        14

<210>  3301
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3301
aggaagaugg cat                                                         13

<210>  3302
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3302
aggaagaugg ca                                                          12

<210>  3303
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3303
aggaagaugg                                                             10

<210>  3304
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3304
aggaagatg                                                              9

<210>  3305
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3305
aggaagat                                                               8

<210>  3306
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3306
ggaagauggc auuucuag                                                    18

<210>  3307
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3307
ggaagauggc auuucta                                                     17

<210>  3308
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3308
ggaagauggc auuuct                                                      16

<210>  3309
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3309
ggaagauggc auutc                                                       15

<210>  3310
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3310
ggaagauggc autt                                                        14

<210>  3311
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3311
ggaagauggc att                                                         13

<210>  3312
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3312
ggaagauggc at                                                          12

<210>  3313
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3313
ggaagauggc a                                                           11

<210>  3314
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3314
ggaagauggc                                                             10

<210>  3315
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3315
ggaagatg                                                               8

<210>  3316
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3316
gaagauggca uuucuag                                                     17

<210>  3317
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3317
gaagauggca uuucta                                                      16

<210>  3318
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3318
gaagauggca uutc                                                        14

<210>  3319
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3319
gaagauggca utt                                                         13

<210>  3320
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3320
gaagauggca tt                                                          12

<210>  3321
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3321
gaagauggca t                                                           11

<210>  3322
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3322
gaagauggca                                                             10

<210>  3323
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3323
gaagauggc                                                              9

<210>  3324
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3324
gaagaugg                                                               8

<210>  3325
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3325
aagauggcau uucuag                                                      16

<210>  3326
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3326
aagauggcau uucta                                                       15

<210>  3327
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3327
aagauggcau uuct                                                        14

<210>  3328
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3328
aagauggcau utc                                                         13

<210>  3329
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3329
aagauggcau tt                                                          12

<210>  3330
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3330
aagauggcat t                                                           11

<210>  3331
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3331
aagauggcat                                                             10

<210>  3332
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3332
aagauggca                                                              9

<210>  3333
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3333
aagauggc                                                               8

<210>  3334
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3334
agauggcauu ucuag                                                       15

<210>  3335
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3335
agauggcauu ucta                                                        14

<210>  3336
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3336
agauggcauu uct                                                         13

<210>  3337
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3337
agauggcauu tc                                                          12

<210>  3338
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3338
agauggcaut t                                                           11

<210>  3339
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3339
agauggcatt                                                             10

<210>  3340
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3340
agauggcat                                                              9

<210>  3341
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3341
agauggca                                                               8

<210>  3342
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  3342
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  3343
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  3343
cuccaacauc aaggaagaug gcauuucta                                        29

<210>  3344
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  3344
cuccaacauc aaggaagaug gcauuuct                                         28

<210>  3345
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3345
cuccaacauc aaggaagaug gcauutc                                          27

<210>  3346
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3346
cuccaacauc aaggaagaug gcautt                                           26

<210>  3347
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3347
cuccaacauc aaggaagaug gcatt                                            25

<210>  3348
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3348
cuccaacauc aaggaagaug gcat                                             24

<210>  3349
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3349
cuccaacauc aaggaagaug gca                                              23

<210>  3350
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3350
cuccaacauc aaggaagaug gc                                               22

<210>  3351
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3351
cuccaacauc aaggaagaug g                                                21

<210>  3352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3352
cuccaacauc aaggaagatg                                                  20

<210>  3353
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3353
cuccaacauc aaggaagat                                                   19

<210>  3354
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3354
cuccaacauc aaggaaga                                                    18

<210>  3355
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3355
cuccaacauc aaggaag                                                     17

<210>  3356
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  3356
uccaacauca aggaagaugg cauuucuag                                        29

<210>  3357
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  3357
uccaacauca aggaagaugg cauuucta                                         28

<210>  3358
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3358
uccaacauca aggaagaugg cauuuct                                          27

<210>  3359
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3359
uccaacauca aggaagaugg cauutc                                           26

<210>  3360
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3360
uccaacauca aggaagaugg cautt                                            25

<210>  3361
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3361
uccaacauca aggaagaugg catt                                             24

<210>  3362
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3362
uccaacauca aggaagaugg cat                                              23

<210>  3363
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3363
uccaacauca aggaagaugg ca                                               22

<210>  3364
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3364
uccaacauca aggaagaugg c                                                21

<210>  3365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3365
uccaacauca aggaagaugg                                                  20

<210>  3366
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3366
uccaacauca aggaagatg                                                   19

<210>  3367
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3367
uccaacauca aggaagat                                                    18

<210>  3368
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3368
uccaacauca aggaaga                                                     17

<210>  3369
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3369
uccaacauca aggaag                                                      16

<210>  3370
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  3370
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  3371
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3371
ccaacaucaa ggaagauggc auuucta                                          27

<210>  3372
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3372
ccaacaucaa ggaagauggc auuuct                                           26

<210>  3373
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3373
ccaacaucaa ggaagauggc auutc                                            25

<210>  3374
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3374
ccaacaucaa ggaagauggc autt                                             24

<210>  3375
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3375
ccaacaucaa ggaagauggc att                                              23

<210>  3376
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3376
ccaacaucaa ggaagauggc at                                               22

<210>  3377
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3377
ccaacaucaa ggaagauggc a                                                21

<210>  3378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3378
ccaacaucaa ggaagauggc                                                  20

<210>  3379
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3379
ccaacaucaa ggaagaugg                                                   19

<210>  3380
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3380
ccaacaucaa ggaagatg                                                    18

<210>  3381
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3381
ccaacaucaa ggaagat                                                     17

<210>  3382
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3382
ccaacaucaa ggaaga                                                      16

<210>  3383
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3383
ccaacaucaa ggaag                                                       15

<210>  3384
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3384
caacaucaag gaagauggca uuucuag                                          27

<210>  3385
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3385
caacaucaag gaagauggca uuucta                                           26

<210>  3386
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3386
caacaucaag gaagauggca uuuct                                            25

<210>  3387
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3387
caacaucaag gaagauggca uutc                                             24

<210>  3388
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3388
caacaucaag gaagauggca utt                                              23

<210>  3389
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3389
caacaucaag gaagauggca tt                                               22

<210>  3390
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3390
caacaucaag gaagauggca t                                                21

<210>  3391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3391
caacaucaag gaagauggca                                                  20

<210>  3392
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3392
caacaucaag gaagauggc                                                   19

<210>  3393
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3393
caacaucaag gaagaugg                                                    18

<210>  3394
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3394
caacaucaag gaagatg                                                     17

<210>  3395
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3395
caacaucaag gaagat                                                      16

<210>  3396
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3396
caacaucaag gaaga                                                       15

<210>  3397
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3397
caacaucaag gaag                                                        14

<210>  3398
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3398
aacaucaagg aagauggcau uucuag                                           26

<210>  3399
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3399
aacaucaagg aagauggcau uucta                                            25

<210>  3400
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3400
aacaucaagg aagauggcau uuct                                             24

<210>  3401
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3401
aacaucaagg aagauggcau utc                                              23

<210>  3402
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3402
aacaucaagg aagauggcau tt                                               22

<210>  3403
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3403
aacaucaagg aagauggcat t                                                21

<210>  3404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3404
aacaucaagg aagauggcat                                                  20

<210>  3405
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3405
aacaucaagg aagauggca                                                   19

<210>  3406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3406
aacaucaagg aagauggc                                                    18

<210>  3407
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3407
aacaucaagg aagaugg                                                     17

<210>  3408
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3408
aacaucaagg aagatg                                                      16

<210>  3409
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3409
aacaucaagg aagat                                                       15

<210>  3410
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3410
aacaucaagg aaga                                                        14

<210>  3411
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3411
aacaucaagg aag                                                         13

<210>  3412
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3412
acaucaagga agauggcauu ucuag                                            25

<210>  3413
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3413
acaucaagga agauggcauu ucta                                             24

<210>  3414
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3414
acaucaagga agauggcauu uct                                              23

<210>  3415
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3415
acaucaagga agauggcauu tc                                               22

<210>  3416
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3416
acaucaagga agauggcaut t                                                21

<210>  3417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3417
acaucaagga agauggcatt                                                  20

<210>  3418
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3418
acaucaagga agauggcat                                                   19

<210>  3419
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3419
acaucaagga agauggca                                                    18

<210>  3420
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3420
acaucaagga agauggc                                                     17

<210>  3421
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3421
acaucaagga agaugg                                                      16

<210>  3422
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3422
acaucaagga agatg                                                       15

<210>  3423
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3423
acaucaagga agat                                                        14

<210>  3424
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3424
acaucaagga aga                                                         13

<210>  3425
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3425
acaucaagga ag                                                          12

<210>  3426
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3426
caucaaggaa gauggcauuu cuag                                             24

<210>  3427
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3427
caucaaggaa gauggcauuu cta                                              23

<210>  3428
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3428
caucaaggaa gauggcauuu ct                                               22

<210>  3429
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3429
caucaaggaa gauggcauut c                                                21

<210>  3430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3430
caucaaggaa gauggcautt                                                  20

<210>  3431
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3431
caucaaggaa gauggcatt                                                   19

<210>  3432
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3432
caucaaggaa gauggcat                                                    18

<210>  3433
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3433
caucaaggaa gauggca                                                     17

<210>  3434
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3434
caucaaggaa gauggc                                                      16

<210>  3435
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3435
caucaaggaa gaugg                                                       15

<210>  3436
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3436
caucaaggaa gatg                                                        14

<210>  3437
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3437
caucaaggaa gat                                                         13

<210>  3438
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3438
caucaaggaa ga                                                          12

<210>  3439
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3439
caucaaggaa g                                                           11

<210>  3440
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3440
aucaaggaag auggcauuuc uag                                              23

<210>  3441
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3441
aucaaggaag auggcauuuc ta                                               22

<210>  3442
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3442
aucaaggaag auggcauuuc t                                                21

<210>  3443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3443
aucaaggaag auggcauutc                                                  20

<210>  3444
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3444
aucaaggaag auggcautt                                                   19

<210>  3445
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3445
aucaaggaag auggcatt                                                    18

<210>  3446
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3446
aucaaggaag auggcat                                                     17

<210>  3447
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3447
aucaaggaag auggca                                                      16

<210>  3448
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3448
aucaaggaag auggc                                                       15

<210>  3449
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3449
aucaaggaag augg                                                        14

<210>  3450
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3450
aucaaggaag atg                                                         13

<210>  3451
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3451
aucaaggaag at                                                          12

<210>  3452
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3452
aucaaggaag a                                                           11

<210>  3453
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3453
aucaaggaag                                                             10

<210>  3454
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3454
gguaaguucu guccaagc                                                    18

<210>  3455
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3455
gtaaguucug uccaagcc                                                    18

<210>  3456
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3456
agucgguaag uucugucc                                                    18

<210>  3457
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3457
ctguccaagc ccgguuga                                                    18

<210>  3458
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3458
taaguucugu ccaag                                                       15

<210>  3459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3459
ttcuguccaa gcccgguuga                                                  20

<210>  3460
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3460
ttcuguccaa gcccggutg                                                   19

<210>  3461
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3461
ttcuguccaa gcccggtt                                                    18

<210>  3462
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3462
ttcuguccaa gcccggt                                                     17

<210>  3463
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3463
ttcuguccaa gcccgg                                                      16

<210>  3464
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3464
ttcuguccaa gcccg                                                       15

<210>  3465
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3465
ttcuguccaa gccc                                                        14

<210>  3466
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3466
ttcuguccaa gcc                                                         13

<210>  3467
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3467
ttcuguccaa gc                                                          12

<210>  3468
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3468
ttcuguccaa g                                                           11

<210>  3469
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3469
ttcuguccaa                                                             10

<210>  3470
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3470
ttcugucca                                                              9

<210>  3471
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3471
ttcugucc                                                               8

<210>  3472
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3472
tcuguccaag cccgguuga                                                   19

<210>  3473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3473
tcuguccaag cccggutg                                                    18

<210>  3474
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3474
tcuguccaag cccggtt                                                     17

<210>  3475
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3475
tcuguccaag cccggt                                                      16

<210>  3476
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3476
tcuguccaag cccgg                                                       15

<210>  3477
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3477
tcuguccaag cccg                                                        14

<210>  3478
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3478
tcuguccaag ccc                                                         13

<210>  3479
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3479
tcuguccaag cc                                                          12

<210>  3480
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3480
tcuguccaag c                                                           11

<210>  3481
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3481
tcuguccaag                                                             10

<210>  3482
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3482
tcuguccaa                                                              9

<210>  3483
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3483
tcugucca                                                               8

<210>  3484
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3484
ctguccaagc ccggutg                                                     17

<210>  3485
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3485
ctguccaagc ccggtt                                                      16

<210>  3486
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3486
ctguccaagc ccggt                                                       15

<210>  3487
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3487
ctguccaagc ccgg                                                        14

<210>  3488
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3488
ctguccaagc ccg                                                         13

<210>  3489
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3489
ctguccaagc cc                                                          12

<210>  3490
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3490
ctguccaagc c                                                           11

<210>  3491
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3491
ctguccaagc                                                             10

<210>  3492
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3492
ctguccaag                                                              9

<210>  3493
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3493
ctguccaa                                                               8

<210>  3494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3494
gtucugucca agcccggutg                                                  20

<210>  3495
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3495
gtucugucca agcccggtt                                                   19

<210>  3496
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3496
gtucugucca agcccggt                                                    18

<210>  3497
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3497
gtucugucca agcccgg                                                     17

<210>  3498
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3498
gtucugucca agcccg                                                      16

<210>  3499
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3499
gtucugucca agccc                                                       15

<210>  3500
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3500
gtucugucca agcc                                                        14

<210>  3501
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3501
gtucugucca agc                                                         13

<210>  3502
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3502
gtucugucca ag                                                          12

<210>  3503
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3503
gtucugucca a                                                           11

<210>  3504
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3504
gtucugucca                                                             10

<210>  3505
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3505
gtucugucc                                                              9

<210>  3506
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3506
gtucugtc                                                               8

<210>  3507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3507
aguucugucc aagcccggtt                                                  20

<210>  3508
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3508
aguucugucc aagcccggt                                                   19

<210>  3509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3509
aguucugucc aagcccgg                                                    18

<210>  3510
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3510
aguucugucc aagcccg                                                     17

<210>  3511
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3511
aguucugucc aagccc                                                      16

<210>  3512
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3512
aguucugucc aagcc                                                       15

<210>  3513
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3513
aguucugucc aagc                                                        14

<210>  3514
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3514
aguucugucc aag                                                         13

<210>  3515
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3515
aguucugucc aa                                                          12

<210>  3516
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3516
aguucugucc a                                                           11

<210>  3517
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3517
aguucugucc                                                             10

<210>  3518
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3518
aguucugtc                                                              9

<210>  3519
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3519
aguucugt                                                               8

<210>  3520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3520
aaguucuguc caagcccggt                                                  20

<210>  3521
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3521
aaguucuguc caagcccgg                                                   19

<210>  3522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3522
aaguucuguc caagcccg                                                    18

<210>  3523
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3523
aaguucuguc caagccc                                                     17

<210>  3524
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3524
aaguucuguc caagcc                                                      16

<210>  3525
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3525
aaguucuguc caagc                                                       15

<210>  3526
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3526
aaguucuguc caag                                                        14

<210>  3527
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3527
aaguucuguc caa                                                         13

<210>  3528
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3528
aaguucuguc ca                                                          12

<210>  3529
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3529
aaguucuguc c                                                           11

<210>  3530
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3530
aaguucugtc                                                             10

<210>  3531
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3531
aaguucugt                                                              9

<210>  3532
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3532
aaguuctg                                                               8

<210>  3533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3533
taaguucugu ccaagcccgg                                                  20

<210>  3534
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3534
taaguucugu ccaagcccg                                                   19

<210>  3535
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3535
taaguucugu ccaagccc                                                    18

<210>  3536
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3536
taaguucugu ccaagcc                                                     17

<210>  3537
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3537
taaguucugu ccaagc                                                      16

<210>  3538
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3538
taaguucugu ccaa                                                        14

<210>  3539
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3539
taaguucugu cca                                                         13

<210>  3540
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3540
taaguucugu cc                                                          12

<210>  3541
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3541
taaguucugt c                                                           11

<210>  3542
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3542
taaguucugt                                                             10

<210>  3543
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3543
taaguuctg                                                              9

<210>  3544
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3544
taaguuct                                                               8

<210>  3545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3545
gtaaguucug uccaagcccg                                                  20

<210>  3546
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3546
gtaaguucug uccaagccc                                                   19

<210>  3547
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3547
gtaaguucug uccaagc                                                     17

<210>  3548
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3548
gtaaguucug uccaag                                                      16

<210>  3549
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3549
gtaaguucug uccaa                                                       15

<210>  3550
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3550
gtaaguucug ucca                                                        14

<210>  3551
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3551
gtaaguucug ucc                                                         13

<210>  3552
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3552
gtaaguucug tc                                                          12

<210>  3553
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3553
gtaaguucug t                                                           11

<210>  3554
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3554
gtaaguuctg                                                             10

<210>  3555
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3555
gtaaguuct                                                              9

<210>  3556
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3556
gtaagutc                                                               8

<210>  3557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3557
gguaaguucu guccaagccc                                                  20

<210>  3558
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3558
gguaaguucu guccaagcc                                                   19

<210>  3559
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3559
gguaaguucu guccaag                                                     17

<210>  3560
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3560
gguaaguucu guccaa                                                      16

<210>  3561
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3561
gguaaguucu gucca                                                       15

<210>  3562
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3562
gguaaguucu gucc                                                        14

<210>  3563
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3563
gguaaguucu gtc                                                         13

<210>  3564
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3564
gguaaguucu gt                                                          12

<210>  3565
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3565
gguaaguuct g                                                           11

<210>  3566
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3566
gguaaguuct                                                             10

<210>  3567
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3567
gguaagutc                                                              9

<210>  3568
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3568
gguaagtt                                                               8

<210>  3569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3569
cgguaaguuc uguccaagcc                                                  20

<210>  3570
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3570
cgguaaguuc uguccaagc                                                   19

<210>  3571
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3571
cgguaaguuc uguccaag                                                    18

<210>  3572
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3572
cgguaaguuc uguccaa                                                     17

<210>  3573
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3573
cgguaaguuc ugucca                                                      16

<210>  3574
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3574
cgguaaguuc ugucc                                                       15

<210>  3575
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3575
cgguaaguuc ugtc                                                        14

<210>  3576
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3576
cgguaaguuc ugt                                                         13

<210>  3577
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3577
cgguaaguuc tg                                                          12

<210>  3578
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3578
cgguaaguuc t                                                           11

<210>  3579
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3579
cgguaagutc                                                             10

<210>  3580
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3580
cgguaagtt                                                              9

<210>  3581
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3581
cgguaagt                                                               8

<210>  3582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3582
tcgguaaguu cuguccaagc                                                  20

<210>  3583
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3583
tcgguaaguu cuguccaag                                                   19

<210>  3584
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3584
tcgguaaguu cuguccaa                                                    18

<210>  3585
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3585
tcgguaaguu cugucca                                                     17

<210>  3586
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3586
tcgguaaguu cugucc                                                      16

<210>  3587
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3587
tcgguaaguu cugtc                                                       15

<210>  3588
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3588
tcgguaaguu cugt                                                        14

<210>  3589
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3589
tcgguaaguu ctg                                                         13

<210>  3590
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3590
tcgguaaguu ct                                                          12

<210>  3591
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3591
tcgguaagut c                                                           11

<210>  3592
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3592
tcgguaagtt                                                             10

<210>  3593
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3593
tcgguaagt                                                              9

<210>  3594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3594
gtcgguaagu ucuguccaag                                                  20

<210>  3595
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3595
gtcgguaagu ucuguccaa                                                   19

<210>  3596
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3596
gtcgguaagu ucugucca                                                    18

<210>  3597
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3597
gtcgguaagu ucugucc                                                     17

<210>  3598
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3598
gtcgguaagu ucugtc                                                      16

<210>  3599
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3599
gtcgguaagu ucugt                                                       15

<210>  3600
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3600
gtcgguaagu uctg                                                        14

<210>  3601
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3601
gtcgguaagu uct                                                         13

<210>  3602
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3602
gtcgguaagu tc                                                          12

<210>  3603
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3603
gtcgguaagt t                                                           11

<210>  3604
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3604
gtcgguaagt                                                             10

<210>  3605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3605
agucgguaag uucuguccaa                                                  20

<210>  3606
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3606
agucgguaag uucugucca                                                   19

<210>  3607
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3607
agucgguaag uucugtc                                                     17

<210>  3608
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3608
agucgguaag uucugt                                                      16

<210>  3609
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3609
agucgguaag uuctg                                                       15

<210>  3610
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3610
agucgguaag uuct                                                        14

<210>  3611
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3611
agucgguaag utc                                                         13

<210>  3612
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3612
agucgguaag tt                                                          12

<210>  3613
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3613
agucgguaag t                                                           11

<210>  3614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3614
cagucgguaa guucugucca                                                  20

<210>  3615
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3615
cagucgguaa guucugucc                                                   19

<210>  3616
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3616
cagucgguaa guucugtc                                                    18

<210>  3617
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3617
cagucgguaa guucugt                                                     17

<210>  3618
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3618
cagucgguaa guuctg                                                      16

<210>  3619
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3619
cagucgguaa guuct                                                       15

<210>  3620
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3620
cagucgguaa gutc                                                        14

<210>  3621
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3621
cagucgguaa gtt                                                         13

<210>  3622
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3622
cagucgguaa gt                                                          12

<210>  3623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3623
ccagucggua aguucugucc                                                  20

<210>  3624
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3624
ccagucggua aguucugtc                                                   19

<210>  3625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3625
ccagucggua aguucugt                                                    18

<210>  3626
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3626
ccagucggua aguuctg                                                     17

<210>  3627
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3627
ccagucggua aguuct                                                      16

<210>  3628
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3628
ccagucggua agutc                                                       15

<210>  3629
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3629
ccagucggua agtt                                                        14

<210>  3630
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3630
ccagucggua agt                                                         13

<210>  3631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3631
gccagucggu aaguucugtc                                                  20

<210>  3632
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3632
gccagucggu aaguucugt                                                   19

<210>  3633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3633
gccagucggu aaguuctg                                                    18

<210>  3634
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3634
gccagucggu aaguuct                                                     17

<210>  3635
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3635
gccagucggu aagutc                                                      16

<210>  3636
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3636
gccagucggu aagtt                                                       15

<210>  3637
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3637
gccagucggu aagt                                                        14

<210>  3638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3638
tcaaggaaga uggcauuuct                                                  20

<210>  3639
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3639
tcaaggaaga uggcauuucu ag                                               22

<210>  3640
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3640
tcaaggaaga uggcat                                                      16

<210>  3641
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3641
gaagauggca uuuct                                                       15

<210>  3642
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3642
tcaaggaaga uggcauuuct a                                                21

<210>  3643
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3643
tcaaggaaga uggcauutc                                                   19

<210>  3644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3644
tcaaggaaga uggcautt                                                    18

<210>  3645
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3645
tcaaggaaga uggcatt                                                     17

<210>  3646
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3646
tcaaggaaga uggca                                                       15

<210>  3647
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3647
tcaaggaaga uggc                                                        14

<210>  3648
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3648
tcaaggaaga ugg                                                         13

<210>  3649
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3649
tcaaggaaga tg                                                          12

<210>  3650
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3650
tcaaggaaga t                                                           11

<210>  3651
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3651
tcaaggaaga                                                             10

<210>  3652
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3652
tcaaggaag                                                              9

<210>  3653
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3653
caaggaagau ggcauuucua g                                                21

<210>  3654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3654
caaggaagau ggcauuucta                                                  20

<210>  3655
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3655
caaggaagau ggcauuuct                                                   19

<210>  3656
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3656
caaggaagau ggcauutc                                                    18

<210>  3657
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3657
caaggaagau ggcautt                                                     17

<210>  3658
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3658
caaggaagau ggcatt                                                      16

<210>  3659
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3659
caaggaagau ggcat                                                       15

<210>  3660
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3660
caaggaagau ggca                                                        14

<210>  3661
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3661
caaggaagau ggc                                                         13

<210>  3662
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3662
caaggaagau gg                                                          12

<210>  3663
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3663
caaggaagat g                                                           11

<210>  3664
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3664
caaggaagat                                                             10

<210>  3665
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3665
caaggaaga                                                              9

<210>  3666
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3666
caaggaag                                                               8

<210>  3667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3667
aaggaagaug gcauuucuag                                                  20

<210>  3668
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3668
aaggaagaug gcauuucta                                                   19

<210>  3669
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3669
aaggaagaug gcauuuct                                                    18

<210>  3670
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3670
aaggaagaug gcauutc                                                     17

<210>  3671
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3671
aaggaagaug gcautt                                                      16

<210>  3672
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3672
aaggaagaug gcatt                                                       15

<210>  3673
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3673
aaggaagaug gcat                                                        14

<210>  3674
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3674
aaggaagaug gca                                                         13

<210>  3675
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3675
aaggaagaug gc                                                          12

<210>  3676
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3676
aaggaagaug g                                                           11

<210>  3677
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3677
aaggaagatg                                                             10

<210>  3678
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3678
aaggaagat                                                              9

<210>  3679
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3679
aaggaaga                                                               8

<210>  3680
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3680
aggaagaugg cauuucuag                                                   19

<210>  3681
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3681
aggaagaugg cauuucta                                                    18

<210>  3682
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3682
aggaagaugg cauuuct                                                     17

<210>  3683
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3683
aggaagaugg cauutc                                                      16

<210>  3684
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3684
aggaagaugg cautt                                                       15

<210>  3685
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3685
aggaagaugg catt                                                        14

<210>  3686
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3686
aggaagaugg cat                                                         13

<210>  3687
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3687
aggaagaugg ca                                                          12

<210>  3688
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3688
aggaagaugg                                                             10

<210>  3689
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3689
aggaagatg                                                              9

<210>  3690
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3690
aggaagat                                                               8

<210>  3691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3691
ggaagauggc auuucuag                                                    18

<210>  3692
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3692
ggaagauggc auuucta                                                     17

<210>  3693
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3693
ggaagauggc auuuct                                                      16

<210>  3694
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3694
ggaagauggc auutc                                                       15

<210>  3695
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3695
ggaagauggc autt                                                        14

<210>  3696
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3696
ggaagauggc att                                                         13

<210>  3697
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3697
ggaagauggc at                                                          12

<210>  3698
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3698
ggaagauggc a                                                           11

<210>  3699
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3699
ggaagauggc                                                             10

<210>  3700
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3700
ggaagatg                                                               8

<210>  3701
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3701
gaagauggca uuucuag                                                     17

<210>  3702
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3702
gaagauggca uuucta                                                      16

<210>  3703
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3703
gaagauggca uutc                                                        14

<210>  3704
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3704
gaagauggca utt                                                         13

<210>  3705
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3705
gaagauggca tt                                                          12

<210>  3706
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3706
gaagauggca t                                                           11

<210>  3707
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3707
gaagauggca                                                             10

<210>  3708
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3708
gaagauggc                                                              9

<210>  3709
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3709
gaagaugg                                                               8

<210>  3710
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3710
aagauggcau uucuag                                                      16

<210>  3711
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3711
aagauggcau uucta                                                       15

<210>  3712
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3712
aagauggcau uuct                                                        14

<210>  3713
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3713
aagauggcau utc                                                         13

<210>  3714
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3714
aagauggcau tt                                                          12

<210>  3715
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3715
aagauggcat t                                                           11

<210>  3716
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3716
aagauggcat                                                             10

<210>  3717
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3717
aagauggca                                                              9

<210>  3718
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3718
aagauggc                                                               8

<210>  3719
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3719
agauggcauu ucuag                                                       15

<210>  3720
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3720
agauggcauu ucta                                                        14

<210>  3721
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3721
agauggcauu uct                                                         13

<210>  3722
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3722
agauggcauu tc                                                          12

<210>  3723
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3723
agauggcaut t                                                           11

<210>  3724
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3724
agauggcatt                                                             10

<210>  3725
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  3725
agauggcat                                                              9

<210>  3726
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  3726
agauggca                                                               8

<210>  3727
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  3727
ctccaacauc aaggaagaug gcauuucuag                                       30

<210>  3728
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  3728
ctccaacauc aaggaagaug gcauuucta                                        29

<210>  3729
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  3729
ctccaacauc aaggaagaug gcauuuct                                         28

<210>  3730
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3730
ctccaacauc aaggaagaug gcauutc                                          27

<210>  3731
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3731
ctccaacauc aaggaagaug gcautt                                           26

<210>  3732
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3732
ctccaacauc aaggaagaug gcatt                                            25

<210>  3733
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3733
ctccaacauc aaggaagaug gcat                                             24

<210>  3734
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3734
ctccaacauc aaggaagaug gca                                              23

<210>  3735
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3735
ctccaacauc aaggaagaug gc                                               22

<210>  3736
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3736
ctccaacauc aaggaagaug g                                                21

<210>  3737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3737
ctccaacauc aaggaagatg                                                  20

<210>  3738
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3738
ctccaacauc aaggaagat                                                   19

<210>  3739
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3739
ctccaacauc aaggaaga                                                    18

<210>  3740
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3740
ctccaacauc aaggaag                                                     17

<210>  3741
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  3741
tccaacauca aggaagaugg cauuucuag                                        29

<210>  3742
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  3742
tccaacauca aggaagaugg cauuucta                                         28

<210>  3743
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3743
tccaacauca aggaagaugg cauuuct                                          27

<210>  3744
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3744
tccaacauca aggaagaugg cauutc                                           26

<210>  3745
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3745
tccaacauca aggaagaugg cautt                                            25

<210>  3746
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3746
tccaacauca aggaagaugg catt                                             24

<210>  3747
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3747
tccaacauca aggaagaugg cat                                              23

<210>  3748
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3748
tccaacauca aggaagaugg ca                                               22

<210>  3749
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3749
tccaacauca aggaagaugg c                                                21

<210>  3750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3750
tccaacauca aggaagaugg                                                  20

<210>  3751
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3751
tccaacauca aggaagatg                                                   19

<210>  3752
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3752
tccaacauca aggaagat                                                    18

<210>  3753
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3753
tccaacauca aggaaga                                                     17

<210>  3754
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3754
tccaacauca aggaag                                                      16

<210>  3755
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  3755
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  3756
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3756
ccaacaucaa ggaagauggc auuucta                                          27

<210>  3757
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3757
ccaacaucaa ggaagauggc auuuct                                           26

<210>  3758
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3758
ccaacaucaa ggaagauggc auutc                                            25

<210>  3759
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3759
ccaacaucaa ggaagauggc autt                                             24

<210>  3760
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3760
ccaacaucaa ggaagauggc att                                              23

<210>  3761
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3761
ccaacaucaa ggaagauggc at                                               22

<210>  3762
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3762
ccaacaucaa ggaagauggc a                                                21

<210>  3763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3763
ccaacaucaa ggaagauggc                                                  20

<210>  3764
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3764
ccaacaucaa ggaagaugg                                                   19

<210>  3765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3765
ccaacaucaa ggaagatg                                                    18

<210>  3766
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3766
ccaacaucaa ggaagat                                                     17

<210>  3767
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3767
ccaacaucaa ggaaga                                                      16

<210>  3768
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3768
ccaacaucaa ggaag                                                       15

<210>  3769
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  3769
caacaucaag gaagauggca uuucuag                                          27

<210>  3770
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3770
caacaucaag gaagauggca uuucta                                           26

<210>  3771
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3771
caacaucaag gaagauggca uuuct                                            25

<210>  3772
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3772
caacaucaag gaagauggca uutc                                             24

<210>  3773
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3773
caacaucaag gaagauggca utt                                              23

<210>  3774
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3774
caacaucaag gaagauggca tt                                               22

<210>  3775
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3775
caacaucaag gaagauggca t                                                21

<210>  3776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3776
caacaucaag gaagauggca                                                  20

<210>  3777
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3777
caacaucaag gaagauggc                                                   19

<210>  3778
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3778
caacaucaag gaagaugg                                                    18

<210>  3779
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3779
caacaucaag gaagatg                                                     17

<210>  3780
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3780
caacaucaag gaagat                                                      16

<210>  3781
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3781
caacaucaag gaaga                                                       15

<210>  3782
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3782
caacaucaag gaag                                                        14

<210>  3783
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  3783
aacaucaagg aagauggcau uucuag                                           26

<210>  3784
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3784
aacaucaagg aagauggcau uucta                                            25

<210>  3785
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3785
aacaucaagg aagauggcau uuct                                             24

<210>  3786
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3786
aacaucaagg aagauggcau utc                                              23

<210>  3787
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3787
aacaucaagg aagauggcau tt                                               22

<210>  3788
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3788
aacaucaagg aagauggcat t                                                21

<210>  3789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3789
aacaucaagg aagauggcat                                                  20

<210>  3790
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3790
aacaucaagg aagauggca                                                   19

<210>  3791
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3791
aacaucaagg aagauggc                                                    18

<210>  3792
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3792
aacaucaagg aagaugg                                                     17

<210>  3793
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3793
aacaucaagg aagatg                                                      16

<210>  3794
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3794
aacaucaagg aagat                                                       15

<210>  3795
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3795
aacaucaagg aaga                                                        14

<210>  3796
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3796
aacaucaagg aag                                                         13

<210>  3797
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  3797
acaucaagga agauggcauu ucuag                                            25

<210>  3798
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3798
acaucaagga agauggcauu ucta                                             24

<210>  3799
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3799
acaucaagga agauggcauu uct                                              23

<210>  3800
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3800
acaucaagga agauggcauu tc                                               22

<210>  3801
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3801
acaucaagga agauggcaut t                                                21

<210>  3802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3802
acaucaagga agauggcatt                                                  20

<210>  3803
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3803
acaucaagga agauggcat                                                   19

<210>  3804
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3804
acaucaagga agauggca                                                    18

<210>  3805
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3805
acaucaagga agauggc                                                     17

<210>  3806
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3806
acaucaagga agaugg                                                      16

<210>  3807
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3807
acaucaagga agatg                                                       15

<210>  3808
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3808
acaucaagga agat                                                        14

<210>  3809
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3809
acaucaagga aga                                                         13

<210>  3810
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3810
acaucaagga ag                                                          12

<210>  3811
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  3811
caucaaggaa gauggcauuu cuag                                             24

<210>  3812
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3812
caucaaggaa gauggcauuu cta                                              23

<210>  3813
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3813
caucaaggaa gauggcauuu ct                                               22

<210>  3814
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3814
caucaaggaa gauggcauut c                                                21

<210>  3815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3815
caucaaggaa gauggcautt                                                  20

<210>  3816
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3816
caucaaggaa gauggcatt                                                   19

<210>  3817
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3817
caucaaggaa gauggcat                                                    18

<210>  3818
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3818
caucaaggaa gauggca                                                     17

<210>  3819
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3819
caucaaggaa gauggc                                                      16

<210>  3820
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3820
caucaaggaa gaugg                                                       15

<210>  3821
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3821
caucaaggaa gatg                                                        14

<210>  3822
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3822
caucaaggaa gat                                                         13

<210>  3823
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3823
caucaaggaa ga                                                          12

<210>  3824
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3824
caucaaggaa g                                                           11

<210>  3825
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  3825
atcaaggaag auggcauuuc uag                                              23

<210>  3826
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  3826
atcaaggaag auggcauuuc ta                                               22

<210>  3827
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  3827
atcaaggaag auggcauuuc t                                                21

<210>  3828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  3828
atcaaggaag auggcauutc                                                  20

<210>  3829
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  3829
atcaaggaag auggcautt                                                   19

<210>  3830
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  3830
atcaaggaag auggcatt                                                    18

<210>  3831
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  3831
atcaaggaag auggcat                                                     17

<210>  3832
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  3832
atcaaggaag auggca                                                      16

<210>  3833
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  3833
atcaaggaag auggc                                                       15

<210>  3834
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  3834
atcaaggaag augg                                                        14

<210>  3835
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  3835
atcaaggaag atg                                                         13

<210>  3836
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  3836
atcaaggaag at                                                          12

<210>  3837
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  3837
atcaaggaag a                                                           11

<210>  3838
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  3838
atcaaggaag                                                             10

<210>  3839
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  3839
gguaaguucu guccaagc                                                    18

<210>  3840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  3840
guaaguucug uccaagcc                                                    18

<210>  3841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  3841
agucgguaag uucugucc                                                    18

<210>  3842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3842
cuguccaagc ccgguuga                                                    18

<210>  3843
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  3843
taaguucugu ccaag                                                       15

<210>  3844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3844
tucuguccaa gcccgguuga                                                  20

<210>  3845
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3845
tucuguccaa gcccgguug                                                   19

<210>  3846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3846
tucuguccaa gcccgguu                                                    18

<210>  3847
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3847
tucuguccaa gcccggu                                                     17

<210>  3848
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3848
tucuguccaa gcccgg                                                      16

<210>  3849
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3849
tucuguccaa gcccg                                                       15

<210>  3850
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  3850
tucuguccaa gccc                                                        14

<210>  3851
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  3851
tucuguccaa gcc                                                         13

<210>  3852
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  3852
tucuguccaa gc                                                          12

<210>  3853
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  3853
tucuguccaa g                                                           11

<210>  3854
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  3854
tucuguccaa                                                             10

<210>  3855
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  3855
tucugucca                                                              9

<210>  3856
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  3856
tucugucc                                                               8

<210>  3857
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3857
tcuguccaag cccgguuga                                                   19

<210>  3858
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3858
tcuguccaag cccgguug                                                    18

<210>  3859
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3859
tcuguccaag cccgguu                                                     17

<210>  3860
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3860
tcuguccaag cccggu                                                      16

<210>  3861
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3861
tcuguccaag cccgg                                                       15

<210>  3862
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3862
tcuguccaag cccg                                                        14

<210>  3863
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  3863
tcuguccaag ccc                                                         13

<210>  3864
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  3864
tcuguccaag cc                                                          12

<210>  3865
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  3865
tcuguccaag c                                                           11

<210>  3866
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  3866
tcuguccaag                                                             10

<210>  3867
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  3867
tcuguccaa                                                              9

<210>  3868
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  3868
tcugucca                                                               8

<210>  3869
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3869
cuguccaagc ccgguug                                                     17

<210>  3870
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3870
cuguccaagc ccgguu                                                      16

<210>  3871
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3871
cuguccaagc ccggu                                                       15

<210>  3872
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3872
cuguccaagc ccgg                                                        14

<210>  3873
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3873
cuguccaagc ccg                                                         13

<210>  3874
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3874
cuguccaagc cc                                                          12

<210>  3875
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3875
cuguccaagc c                                                           11

<210>  3876
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3876
cuguccaagc                                                             10

<210>  3877
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3877
cuguccaag                                                              9

<210>  3878
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3878
cuguccaa                                                               8

<210>  3879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  3879
guucugucca agcccgguug                                                  20

<210>  3880
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  3880
guucugucca agcccgguu                                                   19

<210>  3881
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  3881
guucugucca agcccggu                                                    18

<210>  3882
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  3882
guucugucca agcccgg                                                     17

<210>  3883
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  3883
guucugucca agcccg                                                      16

<210>  3884
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  3884
guucugucca agccc                                                       15

<210>  3885
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  3885
guucugucca agcc                                                        14

<210>  3886
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  3886
guucugucca agc                                                         13

<210>  3887
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  3887
guucugucca ag                                                          12

<210>  3888
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  3888
guucugucca a                                                           11

<210>  3889
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  3889
guucugucca                                                             10

<210>  3890
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  3890
guucugucc                                                              9

<210>  3891
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  3891
guucuguc                                                               8

<210>  3892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  3892
aguucugucc aagcccgguu                                                  20

<210>  3893
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  3893
aguucugucc aagcccggu                                                   19

<210>  3894
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  3894
aguucugucc aagcccgg                                                    18

<210>  3895
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  3895
aguucugucc aagcccg                                                     17

<210>  3896
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  3896
aguucugucc aagccc                                                      16

<210>  3897
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  3897
aguucugucc aagcc                                                       15

<210>  3898
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  3898
aguucugucc aagc                                                        14

<210>  3899
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  3899
aguucugucc aag                                                         13

<210>  3900
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  3900
aguucugucc aa                                                          12

<210>  3901
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  3901
aguucugucc a                                                           11

<210>  3902
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  3902
aguucugucc                                                             10

<210>  3903
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  3903
aguucuguc                                                              9

<210>  3904
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  3904
aguucugu                                                               8

<210>  3905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  3905
aaguucuguc caagcccggu                                                  20

<210>  3906
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  3906
aaguucuguc caagcccgg                                                   19

<210>  3907
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  3907
aaguucuguc caagcccg                                                    18

<210>  3908
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  3908
aaguucuguc caagccc                                                     17

<210>  3909
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  3909
aaguucuguc caagcc                                                      16

<210>  3910
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  3910
aaguucuguc caagc                                                       15

<210>  3911
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  3911
aaguucuguc caag                                                        14

<210>  3912
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  3912
aaguucuguc caa                                                         13

<210>  3913
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  3913
aaguucuguc ca                                                          12

<210>  3914
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  3914
aaguucuguc c                                                           11

<210>  3915
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  3915
aaguucuguc                                                             10

<210>  3916
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  3916
aaguucugu                                                              9

<210>  3917
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  3917
aaguucug                                                               8

<210>  3918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  3918
taaguucugu ccaagcccgg                                                  20

<210>  3919
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  3919
taaguucugu ccaagcccg                                                   19

<210>  3920
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  3920
taaguucugu ccaagccc                                                    18

<210>  3921
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  3921
taaguucugu ccaagcc                                                     17

<210>  3922
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  3922
taaguucugu ccaagc                                                      16

<210>  3923
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  3923
taaguucugu ccaa                                                        14

<210>  3924
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  3924
taaguucugu cca                                                         13

<210>  3925
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  3925
taaguucugu cc                                                          12

<210>  3926
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  3926
taaguucugu c                                                           11

<210>  3927
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  3927
taaguucugu                                                             10

<210>  3928
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  3928
taaguucug                                                              9

<210>  3929
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  3929
taaguucu                                                               8

<210>  3930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  3930
guaaguucug uccaagcccg                                                  20

<210>  3931
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  3931
guaaguucug uccaagccc                                                   19

<210>  3932
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  3932
guaaguucug uccaagc                                                     17

<210>  3933
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  3933
guaaguucug uccaag                                                      16

<210>  3934
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  3934
guaaguucug uccaa                                                       15

<210>  3935
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  3935
guaaguucug ucca                                                        14

<210>  3936
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  3936
guaaguucug ucc                                                         13

<210>  3937
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  3937
guaaguucug uc                                                          12

<210>  3938
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  3938
guaaguucug u                                                           11

<210>  3939
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  3939
guaaguucug                                                             10

<210>  3940
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  3940
guaaguucu                                                              9

<210>  3941
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  3941
guaaguuc                                                               8

<210>  3942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  3942
gguaaguucu guccaagccc                                                  20

<210>  3943
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  3943
gguaaguucu guccaagcc                                                   19

<210>  3944
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  3944
gguaaguucu guccaag                                                     17

<210>  3945
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  3945
gguaaguucu guccaa                                                      16

<210>  3946
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  3946
gguaaguucu gucca                                                       15

<210>  3947
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  3947
gguaaguucu gucc                                                        14

<210>  3948
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  3948
gguaaguucu guc                                                         13

<210>  3949
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  3949
gguaaguucu gu                                                          12

<210>  3950
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  3950
gguaaguucu g                                                           11

<210>  3951
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  3951
gguaaguucu                                                             10

<210>  3952
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  3952
gguaaguuc                                                              9

<210>  3953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3953
cgguaaguuc uguccaagcc                                                  20

<210>  3954
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3954
cgguaaguuc uguccaagc                                                   19

<210>  3955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3955
cgguaaguuc uguccaag                                                    18

<210>  3956
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3956
cgguaaguuc uguccaa                                                     17

<210>  3957
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3957
cgguaaguuc ugucca                                                      16

<210>  3958
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3958
cgguaaguuc ugucc                                                       15

<210>  3959
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3959
cgguaaguuc uguc                                                        14

<210>  3960
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3960
cgguaaguuc ugu                                                         13

<210>  3961
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3961
cgguaaguuc ug                                                          12

<210>  3962
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3962
cgguaaguuc u                                                           11

<210>  3963
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3963
cgguaaguuc                                                             10

<210>  3964
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3964
cgguaaguu                                                              9

<210>  3965
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3965
cgguaagu                                                               8

<210>  3966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  3966
tcgguaaguu cuguccaagc                                                  20

<210>  3967
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  3967
tcgguaaguu cuguccaag                                                   19

<210>  3968
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  3968
tcgguaaguu cuguccaa                                                    18

<210>  3969
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  3969
tcgguaaguu cugucca                                                     17

<210>  3970
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  3970
tcgguaaguu cugucc                                                      16

<210>  3971
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  3971
tcgguaaguu cuguc                                                       15

<210>  3972
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  3972
tcgguaaguu cugu                                                        14

<210>  3973
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  3973
tcgguaaguu cug                                                         13

<210>  3974
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  3974
tcgguaaguu cu                                                          12

<210>  3975
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  3975
tcgguaaguu c                                                           11

<210>  3976
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  3976
tcgguaaguu                                                             10

<210>  3977
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  3977
tcgguaagu                                                              9

<210>  3978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  3978
gucgguaagu ucuguccaag                                                  20

<210>  3979
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  3979
gucgguaagu ucuguccaa                                                   19

<210>  3980
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  3980
gucgguaagu ucugucca                                                    18

<210>  3981
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  3981
gucgguaagu ucugucc                                                     17

<210>  3982
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  3982
gucgguaagu ucuguc                                                      16

<210>  3983
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  3983
gucgguaagu ucugu                                                       15

<210>  3984
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  3984
gucgguaagu ucug                                                        14

<210>  3985
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  3985
gucgguaagu ucu                                                         13

<210>  3986
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  3986
gucgguaagu uc                                                          12

<210>  3987
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  3987
gucgguaagu u                                                           11

<210>  3988
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  3988
gucgguaagu                                                             10

<210>  3989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  3989
agucgguaag uucuguccaa                                                  20

<210>  3990
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  3990
agucgguaag uucugucca                                                   19

<210>  3991
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  3991
agucgguaag uucuguc                                                     17

<210>  3992
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  3992
agucgguaag uucugu                                                      16

<210>  3993
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  3993
agucgguaag uucug                                                       15

<210>  3994
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  3994
agucgguaag uucu                                                        14

<210>  3995
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  3995
agucgguaag uuc                                                         13

<210>  3996
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  3996
agucgguaag uu                                                          12

<210>  3997
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  3997
agucgguaag u                                                           11

<210>  3998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3998
cagucgguaa guucugucca                                                  20

<210>  3999
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  3999
cagucgguaa guucugucc                                                   19

<210>  4000
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4000
cagucgguaa guucuguc                                                    18

<210>  4001
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4001
cagucgguaa guucugu                                                     17

<210>  4002
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4002
cagucgguaa guucug                                                      16

<210>  4003
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4003
cagucgguaa guucu                                                       15

<210>  4004
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4004
cagucgguaa guuc                                                        14

<210>  4005
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4005
cagucgguaa guu                                                         13

<210>  4006
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4006
cagucgguaa gu                                                          12

<210>  4007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4007
ccagucggua aguucugucc                                                  20

<210>  4008
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4008
ccagucggua aguucuguc                                                   19

<210>  4009
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4009
ccagucggua aguucugu                                                    18

<210>  4010
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4010
ccagucggua aguucug                                                     17

<210>  4011
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4011
ccagucggua aguucu                                                      16

<210>  4012
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4012
ccagucggua aguuc                                                       15

<210>  4013
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4013
ccagucggua aguu                                                        14

<210>  4014
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4014
ccagucggua agu                                                         13

<210>  4015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4015
gccagucggu aaguucuguc                                                  20

<210>  4016
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4016
gccagucggu aaguucugu                                                   19

<210>  4017
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4017
gccagucggu aaguucug                                                    18

<210>  4018
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4018
gccagucggu aaguucu                                                     17

<210>  4019
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4019
gccagucggu aaguuc                                                      16

<210>  4020
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4020
gccagucggu aaguu                                                       15

<210>  4021
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4021
gccagucggu aagu                                                        14

<210>  4022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4022
tcaaggaaga uggcauuucu                                                  20

<210>  4023
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4023
tcaaggaaga uggcauuucu ag                                               22

<210>  4024
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4024
tcaaggaaga uggcau                                                      16

<210>  4025
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4025
gaagauggca uuucu                                                       15

<210>  4026
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4026
tcaaggaaga uggcauuucu a                                                21

<210>  4027
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4027
tcaaggaaga uggcauuuc                                                   19

<210>  4028
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4028
tcaaggaaga uggcauuu                                                    18

<210>  4029
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4029
tcaaggaaga uggcauu                                                     17

<210>  4030
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4030
tcaaggaaga uggca                                                       15

<210>  4031
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4031
tcaaggaaga uggc                                                        14

<210>  4032
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4032
tcaaggaaga ugg                                                         13

<210>  4033
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4033
tcaaggaaga ug                                                          12

<210>  4034
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4034
tcaaggaaga u                                                           11

<210>  4035
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4035
tcaaggaaga                                                             10

<210>  4036
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4036
tcaaggaag                                                              9

<210>  4037
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4037
caaggaagau ggcauuucua g                                                21

<210>  4038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4038
caaggaagau ggcauuucua                                                  20

<210>  4039
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4039
caaggaagau ggcauuucu                                                   19

<210>  4040
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4040
caaggaagau ggcauuuc                                                    18

<210>  4041
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4041
caaggaagau ggcauuu                                                     17

<210>  4042
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4042
caaggaagau ggcauu                                                      16

<210>  4043
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4043
caaggaagau ggcau                                                       15

<210>  4044
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4044
caaggaagau ggca                                                        14

<210>  4045
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4045
caaggaagau ggc                                                         13

<210>  4046
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4046
caaggaagau gg                                                          12

<210>  4047
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4047
caaggaagau g                                                           11

<210>  4048
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4048
caaggaagau                                                             10

<210>  4049
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4049
caaggaaga                                                              9

<210>  4050
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4050
caaggaag                                                               8

<210>  4051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4051
aaggaagaug gcauuucuag                                                  20

<210>  4052
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4052
aaggaagaug gcauuucua                                                   19

<210>  4053
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4053
aaggaagaug gcauuucu                                                    18

<210>  4054
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4054
aaggaagaug gcauuuc                                                     17

<210>  4055
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4055
aaggaagaug gcauuu                                                      16

<210>  4056
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4056
aaggaagaug gcauu                                                       15

<210>  4057
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4057
aaggaagaug gcau                                                        14

<210>  4058
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4058
aaggaagaug gca                                                         13

<210>  4059
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4059
aaggaagaug gc                                                          12

<210>  4060
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4060
aggaagaugg cauuucuag                                                   19

<210>  4061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4061
aggaagaugg cauuucua                                                    18

<210>  4062
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4062
aggaagaugg cauuucu                                                     17

<210>  4063
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4063
aggaagaugg cauuuc                                                      16

<210>  4064
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4064
aggaagaugg cauuu                                                       15

<210>  4065
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4065
aggaagaugg cauu                                                        14

<210>  4066
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4066
aggaagaugg cau                                                         13

<210>  4067
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4067
aggaagaugg ca                                                          12

<210>  4068
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4068
ggaagauggc auuucuag                                                    18

<210>  4069
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4069
ggaagauggc auuucua                                                     17

<210>  4070
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4070
ggaagauggc auuucu                                                      16

<210>  4071
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4071
ggaagauggc auuuc                                                       15

<210>  4072
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4072
ggaagauggc auuu                                                        14

<210>  4073
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4073
ggaagauggc auu                                                         13

<210>  4074
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4074
ggaagauggc au                                                          12

<210>  4075
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4075
ggaagauggc a                                                           11

<210>  4076
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4076
ggaagauggc                                                             10

<210>  4077
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4077
gaagauggca uuucuag                                                     17

<210>  4078
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4078
gaagauggca uuucua                                                      16

<210>  4079
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4079
gaagauggca uuuc                                                        14

<210>  4080
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4080
gaagauggca uuu                                                         13

<210>  4081
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4081
gaagauggca uu                                                          12

<210>  4082
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4082
gaagauggca u                                                           11

<210>  4083
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4083
gaagauggca                                                             10

<210>  4084
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4084
gaagauggc                                                              9

<210>  4085
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4085
aagauggcau uucuag                                                      16

<210>  4086
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4086
aagauggcau uucua                                                       15

<210>  4087
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4087
aagauggcau uucu                                                        14

<210>  4088
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4088
aagauggcau uuc                                                         13

<210>  4089
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4089
aagauggcau uu                                                          12

<210>  4090
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4090
aagauggcau u                                                           11

<210>  4091
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4091
aagauggcau                                                             10

<210>  4092
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4092
aagauggca                                                              9

<210>  4093
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4093
aagauggc                                                               8

<210>  4094
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4094
agauggcauu ucuag                                                       15

<210>  4095
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4095
agauggcauu ucua                                                        14

<210>  4096
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4096
agauggcauu ucu                                                         13

<210>  4097
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4097
agauggcauu uc                                                          12

<210>  4098
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4098
agauggcauu u                                                           11

<210>  4099
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4099
agauggcauu                                                             10

<210>  4100
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4100
agauggcau                                                              9

<210>  4101
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4101
agauggca                                                               8

<210>  4102
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4102
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  4103
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4103
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  4104
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4104
cuccaacauc aaggaagaug gcauuucu                                         28

<210>  4105
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4105
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  4106
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4106
cuccaacauc aaggaagaug gcauuu                                           26

<210>  4107
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4107
cuccaacauc aaggaagaug gcauu                                            25

<210>  4108
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4108
cuccaacauc aaggaagaug gcau                                             24

<210>  4109
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4109
cuccaacauc aaggaagaug gca                                              23

<210>  4110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4110
cuccaacauc aaggaagaug gc                                               22

<210>  4111
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4111
cuccaacauc aaggaagaug g                                                21

<210>  4112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4112
cuccaacauc aaggaagaug                                                  20

<210>  4113
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4113
cuccaacauc aaggaagau                                                   19

<210>  4114
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4114
cuccaacauc aaggaaga                                                    18

<210>  4115
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4115
cuccaacauc aaggaag                                                     17

<210>  4116
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4116
tccaacauca aggaagaugg cauuucuag                                        29

<210>  4117
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4117
tccaacauca aggaagaugg cauuucua                                         28

<210>  4118
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4118
tccaacauca aggaagaugg cauuucu                                          27

<210>  4119
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4119
tccaacauca aggaagaugg cauuuc                                           26

<210>  4120
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4120
tccaacauca aggaagaugg cauuu                                            25

<210>  4121
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4121
tccaacauca aggaagaugg cauu                                             24

<210>  4122
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4122
tccaacauca aggaagaugg cau                                              23

<210>  4123
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4123
tccaacauca aggaagaugg ca                                               22

<210>  4124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4124
tccaacauca aggaagaugg c                                                21

<210>  4125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4125
tccaacauca aggaagaugg                                                  20

<210>  4126
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4126
tccaacauca aggaagaug                                                   19

<210>  4127
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4127
tccaacauca aggaagau                                                    18

<210>  4128
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4128
tccaacauca aggaaga                                                     17

<210>  4129
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4129
tccaacauca aggaag                                                      16

<210>  4130
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4130
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  4131
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4131
ccaacaucaa ggaagauggc auuucua                                          27

<210>  4132
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4132
ccaacaucaa ggaagauggc auuucu                                           26

<210>  4133
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4133
ccaacaucaa ggaagauggc auuuc                                            25

<210>  4134
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4134
ccaacaucaa ggaagauggc auuu                                             24

<210>  4135
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4135
ccaacaucaa ggaagauggc auu                                              23

<210>  4136
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4136
ccaacaucaa ggaagauggc au                                               22

<210>  4137
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4137
ccaacaucaa ggaagauggc a                                                21

<210>  4138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4138
ccaacaucaa ggaagauggc                                                  20

<210>  4139
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4139
ccaacaucaa ggaagaugg                                                   19

<210>  4140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4140
ccaacaucaa ggaagaug                                                    18

<210>  4141
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4141
ccaacaucaa ggaagau                                                     17

<210>  4142
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4142
ccaacaucaa ggaaga                                                      16

<210>  4143
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4143
ccaacaucaa ggaag                                                       15

<210>  4144
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4144
caacaucaag gaagauggca uuucuag                                          27

<210>  4145
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4145
caacaucaag gaagauggca uuucua                                           26

<210>  4146
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4146
caacaucaag gaagauggca uuucu                                            25

<210>  4147
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4147
caacaucaag gaagauggca uuuc                                             24

<210>  4148
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4148
caacaucaag gaagauggca uuu                                              23

<210>  4149
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4149
caacaucaag gaagauggca uu                                               22

<210>  4150
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4150
caacaucaag gaagauggca u                                                21

<210>  4151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4151
caacaucaag gaagauggca                                                  20

<210>  4152
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4152
caacaucaag gaagauggc                                                   19

<210>  4153
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4153
caacaucaag gaagaugg                                                    18

<210>  4154
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4154
caacaucaag gaagaug                                                     17

<210>  4155
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4155
caacaucaag gaagau                                                      16

<210>  4156
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4156
caacaucaag gaaga                                                       15

<210>  4157
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4157
caacaucaag gaag                                                        14

<210>  4158
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4158
aacaucaagg aagauggcau uucuag                                           26

<210>  4159
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4159
aacaucaagg aagauggcau uucua                                            25

<210>  4160
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4160
aacaucaagg aagauggcau uucu                                             24

<210>  4161
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4161
aacaucaagg aagauggcau uuc                                              23

<210>  4162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4162
aacaucaagg aagauggcau uu                                               22

<210>  4163
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4163
aacaucaagg aagauggcau u                                                21

<210>  4164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4164
aacaucaagg aagauggcau                                                  20

<210>  4165
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4165
aacaucaagg aagauggca                                                   19

<210>  4166
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4166
aacaucaagg aagauggc                                                    18

<210>  4167
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4167
aacaucaagg aagaugg                                                     17

<210>  4168
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4168
aacaucaagg aagaug                                                      16

<210>  4169
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4169
aacaucaagg aagau                                                       15

<210>  4170
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4170
aacaucaagg aaga                                                        14

<210>  4171
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4171
aacaucaagg aag                                                         13

<210>  4172
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4172
acaucaagga agauggcauu ucuag                                            25

<210>  4173
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4173
acaucaagga agauggcauu ucua                                             24

<210>  4174
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4174
acaucaagga agauggcauu ucu                                              23

<210>  4175
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4175
acaucaagga agauggcauu uc                                               22

<210>  4176
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4176
acaucaagga agauggcauu u                                                21

<210>  4177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4177
acaucaagga agauggcauu                                                  20

<210>  4178
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4178
acaucaagga agauggcau                                                   19

<210>  4179
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4179
acaucaagga agauggca                                                    18

<210>  4180
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4180
acaucaagga agauggc                                                     17

<210>  4181
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4181
acaucaagga agaugg                                                      16

<210>  4182
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4182
acaucaagga agaug                                                       15

<210>  4183
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4183
acaucaagga agau                                                        14

<210>  4184
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4184
acaucaagga aga                                                         13

<210>  4185
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4185
acaucaagga ag                                                          12

<210>  4186
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4186
caucaaggaa gauggcauuu cuag                                             24

<210>  4187
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4187
caucaaggaa gauggcauuu cua                                              23

<210>  4188
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4188
caucaaggaa gauggcauuu cu                                               22

<210>  4189
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4189
caucaaggaa gauggcauuu c                                                21

<210>  4190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4190
caucaaggaa gauggcauuu                                                  20

<210>  4191
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4191
caucaaggaa gauggcauu                                                   19

<210>  4192
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4192
caucaaggaa gauggcau                                                    18

<210>  4193
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4193
caucaaggaa gauggca                                                     17

<210>  4194
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4194
caucaaggaa gauggc                                                      16

<210>  4195
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4195
caucaaggaa gaugg                                                       15

<210>  4196
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4196
caucaaggaa gaug                                                        14

<210>  4197
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4197
caucaaggaa gau                                                         13

<210>  4198
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4198
caucaaggaa ga                                                          12

<210>  4199
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  4199
caucaaggaa g                                                           11

<210>  4200
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4200
aucaaggaag auggcauuuc uag                                              23

<210>  4201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4201
aucaaggaag auggcauuuc ua                                               22

<210>  4202
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4202
aucaaggaag auggcauuuc u                                                21

<210>  4203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4203
aucaaggaag auggcauuuc                                                  20

<210>  4204
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4204
aucaaggaag auggcauuu                                                   19

<210>  4205
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4205
aucaaggaag auggcauu                                                    18

<210>  4206
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4206
aucaaggaag auggcau                                                     17

<210>  4207
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4207
aucaaggaag auggca                                                      16

<210>  4208
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4208
aucaaggaag auggc                                                       15

<210>  4209
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4209
aucaaggaag augg                                                        14

<210>  4210
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4210
aucaaggaag aug                                                         13

<210>  4211
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4211
aucaaggaag au                                                          12

<210>  4212
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4212
aucaaggaag a                                                           11

<210>  4213
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4213
aucaaggaag                                                             10

<210>  4214
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4214
gguaaguucu guccaagc                                                    18

<210>  4215
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4215
guaaguucug uccaagcc                                                    18

<210>  4216
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4216
agucgguaag uucugucc                                                    18

<210>  4217
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4217
cuguccaagc ccgguuga                                                    18

<210>  4218
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4218
uaaguucugu ccaag                                                       15

<210>  4219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4219
uucuguccaa gcccgguuga                                                  20

<210>  4220
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4220
uucuguccaa gcccgguug                                                   19

<210>  4221
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4221
uucuguccaa gcccggut                                                    18

<210>  4222
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4222
uucuguccaa gcccggt                                                     17

<210>  4223
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4223
uucuguccaa gcccgg                                                      16

<210>  4224
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4224
uucuguccaa gcccg                                                       15

<210>  4225
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4225
uucuguccaa gccc                                                        14

<210>  4226
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4226
uucuguccaa gcc                                                         13

<210>  4227
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4227
uucuguccaa gc                                                          12

<210>  4228
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4228
uucuguccaa g                                                           11

<210>  4229
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4229
uucuguccaa                                                             10

<210>  4230
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4230
uucugucca                                                              9

<210>  4231
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4231
uucugucc                                                               8

<210>  4232
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4232
ucuguccaag cccgguuga                                                   19

<210>  4233
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4233
ucuguccaag cccgguug                                                    18

<210>  4234
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4234
ucuguccaag cccggut                                                     17

<210>  4235
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4235
ucuguccaag cccggt                                                      16

<210>  4236
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4236
ucuguccaag cccgg                                                       15

<210>  4237
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4237
ucuguccaag cccg                                                        14

<210>  4238
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4238
ucuguccaag ccc                                                         13

<210>  4239
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4239
ucuguccaag cc                                                          12

<210>  4240
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4240
ucuguccaag c                                                           11

<210>  4241
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4241
ucuguccaag                                                             10

<210>  4242
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4242
ucuguccaa                                                              9

<210>  4243
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4243
ucugucca                                                               8

<210>  4244
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4244
cuguccaagc ccgguug                                                     17

<210>  4245
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4245
cuguccaagc ccggut                                                      16

<210>  4246
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4246
cuguccaagc ccggt                                                       15

<210>  4247
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4247
cuguccaagc ccgg                                                        14

<210>  4248
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4248
cuguccaagc ccg                                                         13

<210>  4249
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4249
cuguccaagc cc                                                          12

<210>  4250
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4250
cuguccaagc c                                                           11

<210>  4251
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4251
cuguccaagc                                                             10

<210>  4252
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4252
cuguccaag                                                              9

<210>  4253
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4253
cuguccaa                                                               8

<210>  4254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4254
guucugucca agcccgguug                                                  20

<210>  4255
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4255
guucugucca agcccggut                                                   19

<210>  4256
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4256
guucugucca agcccggt                                                    18

<210>  4257
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4257
guucugucca agcccgg                                                     17

<210>  4258
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4258
guucugucca agcccg                                                      16

<210>  4259
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4259
guucugucca agccc                                                       15

<210>  4260
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4260
guucugucca agcc                                                        14

<210>  4261
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4261
guucugucca agc                                                         13

<210>  4262
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4262
guucugucca ag                                                          12

<210>  4263
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4263
guucugucca a                                                           11

<210>  4264
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4264
guucugucca                                                             10

<210>  4265
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4265
guucugucc                                                              9

<210>  4266
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4266
guucuguc                                                               8

<210>  4267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4267
aguucugucc aagcccggut                                                  20

<210>  4268
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4268
aguucugucc aagcccggt                                                   19

<210>  4269
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4269
aguucugucc aagcccgg                                                    18

<210>  4270
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4270
aguucugucc aagcccg                                                     17

<210>  4271
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4271
aguucugucc aagccc                                                      16

<210>  4272
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4272
aguucugucc aagcc                                                       15

<210>  4273
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4273
aguucugucc aagc                                                        14

<210>  4274
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4274
aguucugucc aag                                                         13

<210>  4275
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4275
aguucugucc aa                                                          12

<210>  4276
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4276
aguucugucc a                                                           11

<210>  4277
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4277
aguucugucc                                                             10

<210>  4278
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4278
aguucuguc                                                              9

<210>  4279
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4279
aguucugt                                                               8

<210>  4280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4280
aaguucuguc caagcccggt                                                  20

<210>  4281
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4281
aaguucuguc caagcccgg                                                   19

<210>  4282
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4282
aaguucuguc caagcccg                                                    18

<210>  4283
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4283
aaguucuguc caagccc                                                     17

<210>  4284
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4284
aaguucuguc caagcc                                                      16

<210>  4285
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4285
aaguucuguc caagc                                                       15

<210>  4286
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4286
aaguucuguc caag                                                        14

<210>  4287
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4287
aaguucuguc caa                                                         13

<210>  4288
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4288
aaguucuguc ca                                                          12

<210>  4289
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4289
aaguucuguc c                                                           11

<210>  4290
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4290
aaguucuguc                                                             10

<210>  4291
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4291
aaguucugt                                                              9

<210>  4292
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4292
aaguucug                                                               8

<210>  4293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4293
uaaguucugu ccaagcccgg                                                  20

<210>  4294
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4294
uaaguucugu ccaagcccg                                                   19

<210>  4295
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4295
uaaguucugu ccaagccc                                                    18

<210>  4296
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4296
uaaguucugu ccaagcc                                                     17

<210>  4297
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4297
uaaguucugu ccaagc                                                      16

<210>  4298
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4298
uaaguucugu ccaa                                                        14

<210>  4299
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4299
uaaguucugu cca                                                         13

<210>  4300
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4300
uaaguucugu cc                                                          12

<210>  4301
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4301
uaaguucugu c                                                           11

<210>  4302
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4302
uaaguucugt                                                             10

<210>  4303
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4303
uaaguucug                                                              9

<210>  4304
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4304
uaaguuct                                                               8

<210>  4305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4305
guaaguucug uccaagcccg                                                  20

<210>  4306
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4306
guaaguucug uccaagccc                                                   19

<210>  4307
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4307
guaaguucug uccaagc                                                     17

<210>  4308
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4308
guaaguucug uccaag                                                      16

<210>  4309
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4309
guaaguucug uccaa                                                       15

<210>  4310
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4310
guaaguucug ucca                                                        14

<210>  4311
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4311
guaaguucug ucc                                                         13

<210>  4312
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4312
guaaguucug uc                                                          12

<210>  4313
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4313
guaaguucug t                                                           11

<210>  4314
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4314
guaaguucug                                                             10

<210>  4315
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4315
guaaguuct                                                              9

<210>  4316
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4316
guaaguuc                                                               8

<210>  4317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4317
gguaaguucu guccaagccc                                                  20

<210>  4318
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4318
gguaaguucu guccaagcc                                                   19

<210>  4319
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4319
gguaaguucu guccaag                                                     17

<210>  4320
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4320
gguaaguucu guccaa                                                      16

<210>  4321
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4321
gguaaguucu gucca                                                       15

<210>  4322
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4322
gguaaguucu gucc                                                        14

<210>  4323
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4323
gguaaguucu guc                                                         13

<210>  4324
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4324
gguaaguucu gt                                                          12

<210>  4325
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4325
gguaaguucu g                                                           11

<210>  4326
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4326
gguaaguuct                                                             10

<210>  4327
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4327
gguaaguuc                                                              9

<210>  4328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4328
cgguaaguuc uguccaagcc                                                  20

<210>  4329
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4329
cgguaaguuc uguccaagc                                                   19

<210>  4330
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4330
cgguaaguuc uguccaag                                                    18

<210>  4331
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4331
cgguaaguuc uguccaa                                                     17

<210>  4332
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4332
cgguaaguuc ugucca                                                      16

<210>  4333
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4333
cgguaaguuc ugucc                                                       15

<210>  4334
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4334
cgguaaguuc uguc                                                        14

<210>  4335
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4335
cgguaaguuc ugt                                                         13

<210>  4336
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4336
cgguaaguuc ug                                                          12

<210>  4337
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4337
cgguaaguuc t                                                           11

<210>  4338
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4338
cgguaaguuc                                                             10

<210>  4339
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4339
cgguaagut                                                              9

<210>  4340
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4340
cgguaagt                                                               8

<210>  4341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4341
ucgguaaguu cuguccaagc                                                  20

<210>  4342
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4342
ucgguaaguu cuguccaag                                                   19

<210>  4343
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4343
ucgguaaguu cuguccaa                                                    18

<210>  4344
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4344
ucgguaaguu cugucca                                                     17

<210>  4345
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4345
ucgguaaguu cugucc                                                      16

<210>  4346
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4346
ucgguaaguu cuguc                                                       15

<210>  4347
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4347
ucgguaaguu cugt                                                        14

<210>  4348
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4348
ucgguaaguu cug                                                         13

<210>  4349
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4349
ucgguaaguu ct                                                          12

<210>  4350
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4350
ucgguaaguu c                                                           11

<210>  4351
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4351
ucgguaagut                                                             10

<210>  4352
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4352
ucgguaagt                                                              9

<210>  4353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4353
gucgguaagu ucuguccaag                                                  20

<210>  4354
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4354
gucgguaagu ucuguccaa                                                   19

<210>  4355
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4355
gucgguaagu ucugucca                                                    18

<210>  4356
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4356
gucgguaagu ucugucc                                                     17

<210>  4357
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4357
gucgguaagu ucuguc                                                      16

<210>  4358
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4358
gucgguaagu ucugt                                                       15

<210>  4359
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4359
gucgguaagu ucug                                                        14

<210>  4360
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4360
gucgguaagu uct                                                         13

<210>  4361
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4361
gucgguaagu uc                                                          12

<210>  4362
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4362
gucgguaagu t                                                           11

<210>  4363
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4363
gucgguaagt                                                             10

<210>  4364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4364
agucgguaag uucuguccaa                                                  20

<210>  4365
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4365
agucgguaag uucugucca                                                   19

<210>  4366
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4366
agucgguaag uucuguc                                                     17

<210>  4367
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4367
agucgguaag uucugt                                                      16

<210>  4368
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4368
agucgguaag uucug                                                       15

<210>  4369
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4369
agucgguaag uuct                                                        14

<210>  4370
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4370
agucgguaag uuc                                                         13

<210>  4371
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4371
agucgguaag ut                                                          12

<210>  4372
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4372
agucgguaag t                                                           11

<210>  4373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4373
cagucgguaa guucugucca                                                  20

<210>  4374
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4374
cagucgguaa guucugucc                                                   19

<210>  4375
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4375
cagucgguaa guucuguc                                                    18

<210>  4376
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4376
cagucgguaa guucugt                                                     17

<210>  4377
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4377
cagucgguaa guucug                                                      16

<210>  4378
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4378
cagucgguaa guuct                                                       15

<210>  4379
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4379
cagucgguaa guuc                                                        14

<210>  4380
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4380
cagucgguaa gut                                                         13

<210>  4381
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4381
cagucgguaa gt                                                          12

<210>  4382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4382
ccagucggua aguucugucc                                                  20

<210>  4383
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4383
ccagucggua aguucuguc                                                   19

<210>  4384
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4384
ccagucggua aguucugt                                                    18

<210>  4385
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4385
ccagucggua aguucug                                                     17

<210>  4386
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4386
ccagucggua aguuct                                                      16

<210>  4387
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4387
ccagucggua aguuc                                                       15

<210>  4388
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4388
ccagucggua agut                                                        14

<210>  4389
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4389
ccagucggua agt                                                         13

<210>  4390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4390
gccagucggu aaguucuguc                                                  20

<210>  4391
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4391
gccagucggu aaguucugt                                                   19

<210>  4392
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4392
gccagucggu aaguucug                                                    18

<210>  4393
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4393
gccagucggu aaguuct                                                     17

<210>  4394
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4394
gccagucggu aaguuc                                                      16

<210>  4395
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4395
gccagucggu aagut                                                       15

<210>  4396
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4396
gccagucggu aagt                                                        14

<210>  4397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4397
ucaaggaaga uggcauuuct                                                  20

<210>  4398
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4398
ucaaggaaga uggcauuucu ag                                               22

<210>  4399
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4399
ucaaggaaga uggcat                                                      16

<210>  4400
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4400
gaagauggca uuuct                                                       15

<210>  4401
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4401
ucaaggaaga uggcauuucu a                                                21

<210>  4402
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4402
ucaaggaaga uggcauuuc                                                   19

<210>  4403
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4403
ucaaggaaga uggcauut                                                    18

<210>  4404
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4404
ucaaggaaga uggcaut                                                     17

<210>  4405
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4405
ucaaggaaga uggca                                                       15

<210>  4406
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4406
ucaaggaaga uggc                                                        14

<210>  4407
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4407
ucaaggaaga ugg                                                         13

<210>  4408
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4408
ucaaggaaga ug                                                          12

<210>  4409
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4409
ucaaggaaga t                                                           11

<210>  4410
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4410
ucaaggaaga                                                             10

<210>  4411
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4411
ucaaggaag                                                              9

<210>  4412
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4412
caaggaagau ggcauuucua g                                                21

<210>  4413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4413
caaggaagau ggcauuucua                                                  20

<210>  4414
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4414
caaggaagau ggcauuuct                                                   19

<210>  4415
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4415
caaggaagau ggcauuuc                                                    18

<210>  4416
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4416
caaggaagau ggcauut                                                     17

<210>  4417
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4417
caaggaagau ggcaut                                                      16

<210>  4418
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4418
caaggaagau ggcat                                                       15

<210>  4419
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4419
caaggaagau ggca                                                        14

<210>  4420
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4420
caaggaagau ggc                                                         13

<210>  4421
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4421
caaggaagau gg                                                          12

<210>  4422
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4422
caaggaagau g                                                           11

<210>  4423
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4423
caaggaagat                                                             10

<210>  4424
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4424
caaggaaga                                                              9

<210>  4425
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4425
caaggaag                                                               8

<210>  4426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4426
aaggaagaug gcauuucuag                                                  20

<210>  4427
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4427
aaggaagaug gcauuucua                                                   19

<210>  4428
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4428
aaggaagaug gcauuuct                                                    18

<210>  4429
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4429
aaggaagaug gcauuuc                                                     17

<210>  4430
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4430
aaggaagaug gcauut                                                      16

<210>  4431
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4431
aaggaagaug gcaut                                                       15

<210>  4432
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4432
aaggaagaug gcat                                                        14

<210>  4433
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4433
aaggaagaug gca                                                         13

<210>  4434
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4434
aaggaagaug gc                                                          12

<210>  4435
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4435
aggaagaugg cauuucuag                                                   19

<210>  4436
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4436
aggaagaugg cauuucua                                                    18

<210>  4437
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4437
aggaagaugg cauuuct                                                     17

<210>  4438
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4438
aggaagaugg cauuuc                                                      16

<210>  4439
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4439
aggaagaugg cauut                                                       15

<210>  4440
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4440
aggaagaugg caut                                                        14

<210>  4441
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4441
aggaagaugg cat                                                         13

<210>  4442
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4442
aggaagaugg ca                                                          12

<210>  4443
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4443
ggaagauggc auuucuag                                                    18

<210>  4444
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4444
ggaagauggc auuucua                                                     17

<210>  4445
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4445
ggaagauggc auuuct                                                      16

<210>  4446
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4446
ggaagauggc auuuc                                                       15

<210>  4447
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4447
ggaagauggc auut                                                        14

<210>  4448
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4448
ggaagauggc aut                                                         13

<210>  4449
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4449
ggaagauggc at                                                          12

<210>  4450
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4450
ggaagauggc a                                                           11

<210>  4451
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4451
ggaagauggc                                                             10

<210>  4452
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4452
gaagauggca uuucuag                                                     17

<210>  4453
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4453
gaagauggca uuucua                                                      16

<210>  4454
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4454
gaagauggca uuuc                                                        14

<210>  4455
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4455
gaagauggca uut                                                         13

<210>  4456
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4456
gaagauggca ut                                                          12

<210>  4457
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4457
gaagauggca t                                                           11

<210>  4458
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4458
gaagauggca                                                             10

<210>  4459
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4459
gaagauggc                                                              9

<210>  4460
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4460
aagauggcau uucuag                                                      16

<210>  4461
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4461
aagauggcau uucua                                                       15

<210>  4462
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4462
aagauggcau uuct                                                        14

<210>  4463
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4463
aagauggcau uuc                                                         13

<210>  4464
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4464
aagauggcau ut                                                          12

<210>  4465
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4465
aagauggcau t                                                           11

<210>  4466
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4466
aagauggcat                                                             10

<210>  4467
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4467
aagauggca                                                              9

<210>  4468
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4468
aagauggc                                                               8

<210>  4469
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4469
agauggcauu ucuag                                                       15

<210>  4470
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4470
agauggcauu ucua                                                        14

<210>  4471
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4471
agauggcauu uct                                                         13

<210>  4472
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4472
agauggcauu uc                                                          12

<210>  4473
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4473
agauggcauu t                                                           11

<210>  4474
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4474
agauggcaut                                                             10

<210>  4475
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4475
agauggcat                                                              9

<210>  4476
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4476
agauggca                                                               8

<210>  4477
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  4477
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  4478
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  4478
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  4479
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  4479
cuccaacauc aaggaagaug gcauuuct                                         28

<210>  4480
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4480
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  4481
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4481
cuccaacauc aaggaagaug gcauut                                           26

<210>  4482
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4482
cuccaacauc aaggaagaug gcaut                                            25

<210>  4483
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4483
cuccaacauc aaggaagaug gcat                                             24

<210>  4484
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4484
cuccaacauc aaggaagaug gca                                              23

<210>  4485
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4485
cuccaacauc aaggaagaug gc                                               22

<210>  4486
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4486
cuccaacauc aaggaagaug g                                                21

<210>  4487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4487
cuccaacauc aaggaagaug                                                  20

<210>  4488
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4488
cuccaacauc aaggaagat                                                   19

<210>  4489
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4489
cuccaacauc aaggaaga                                                    18

<210>  4490
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4490
cuccaacauc aaggaag                                                     17

<210>  4491
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  4491
uccaacauca aggaagaugg cauuucuag                                        29

<210>  4492
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  4492
uccaacauca aggaagaugg cauuucua                                         28

<210>  4493
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4493
uccaacauca aggaagaugg cauuuct                                          27

<210>  4494
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4494
uccaacauca aggaagaugg cauuuc                                           26

<210>  4495
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4495
uccaacauca aggaagaugg cauut                                            25

<210>  4496
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4496
uccaacauca aggaagaugg caut                                             24

<210>  4497
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4497
uccaacauca aggaagaugg cat                                              23

<210>  4498
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4498
uccaacauca aggaagaugg ca                                               22

<210>  4499
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4499
uccaacauca aggaagaugg c                                                21

<210>  4500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4500
uccaacauca aggaagaugg                                                  20

<210>  4501
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4501
uccaacauca aggaagaug                                                   19

<210>  4502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4502
uccaacauca aggaagat                                                    18

<210>  4503
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4503
uccaacauca aggaaga                                                     17

<210>  4504
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4504
uccaacauca aggaag                                                      16

<210>  4505
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  4505
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  4506
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4506
ccaacaucaa ggaagauggc auuucua                                          27

<210>  4507
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4507
ccaacaucaa ggaagauggc auuuct                                           26

<210>  4508
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4508
ccaacaucaa ggaagauggc auuuc                                            25

<210>  4509
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4509
ccaacaucaa ggaagauggc auut                                             24

<210>  4510
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4510
ccaacaucaa ggaagauggc aut                                              23

<210>  4511
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4511
ccaacaucaa ggaagauggc at                                               22

<210>  4512
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4512
ccaacaucaa ggaagauggc a                                                21

<210>  4513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4513
ccaacaucaa ggaagauggc                                                  20

<210>  4514
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4514
ccaacaucaa ggaagaugg                                                   19

<210>  4515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4515
ccaacaucaa ggaagaug                                                    18

<210>  4516
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4516
ccaacaucaa ggaagat                                                     17

<210>  4517
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4517
ccaacaucaa ggaaga                                                      16

<210>  4518
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4518
ccaacaucaa ggaag                                                       15

<210>  4519
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4519
caacaucaag gaagauggca uuucuag                                          27

<210>  4520
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4520
caacaucaag gaagauggca uuucua                                           26

<210>  4521
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4521
caacaucaag gaagauggca uuuct                                            25

<210>  4522
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4522
caacaucaag gaagauggca uuuc                                             24

<210>  4523
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4523
caacaucaag gaagauggca uut                                              23

<210>  4524
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4524
caacaucaag gaagauggca ut                                               22

<210>  4525
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4525
caacaucaag gaagauggca t                                                21

<210>  4526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4526
caacaucaag gaagauggca                                                  20

<210>  4527
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4527
caacaucaag gaagauggc                                                   19

<210>  4528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4528
caacaucaag gaagaugg                                                    18

<210>  4529
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4529
caacaucaag gaagaug                                                     17

<210>  4530
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4530
caacaucaag gaagat                                                      16

<210>  4531
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4531
caacaucaag gaaga                                                       15

<210>  4532
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4532
caacaucaag gaag                                                        14

<210>  4533
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4533
aacaucaagg aagauggcau uucuag                                           26

<210>  4534
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4534
aacaucaagg aagauggcau uucua                                            25

<210>  4535
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4535
aacaucaagg aagauggcau uuct                                             24

<210>  4536
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4536
aacaucaagg aagauggcau uuc                                              23

<210>  4537
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4537
aacaucaagg aagauggcau ut                                               22

<210>  4538
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4538
aacaucaagg aagauggcau t                                                21

<210>  4539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4539
aacaucaagg aagauggcat                                                  20

<210>  4540
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4540
aacaucaagg aagauggca                                                   19

<210>  4541
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4541
aacaucaagg aagauggc                                                    18

<210>  4542
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4542
aacaucaagg aagaugg                                                     17

<210>  4543
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4543
aacaucaagg aagaug                                                      16

<210>  4544
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4544
aacaucaagg aagat                                                       15

<210>  4545
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4545
aacaucaagg aaga                                                        14

<210>  4546
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4546
aacaucaagg aag                                                         13

<210>  4547
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4547
acaucaagga agauggcauu ucuag                                            25

<210>  4548
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4548
acaucaagga agauggcauu ucua                                             24

<210>  4549
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4549
acaucaagga agauggcauu uct                                              23

<210>  4550
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4550
acaucaagga agauggcauu uc                                               22

<210>  4551
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4551
acaucaagga agauggcauu t                                                21

<210>  4552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4552
acaucaagga agauggcaut                                                  20

<210>  4553
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4553
acaucaagga agauggcat                                                   19

<210>  4554
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4554
acaucaagga agauggca                                                    18

<210>  4555
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4555
acaucaagga agauggc                                                     17

<210>  4556
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4556
acaucaagga agaugg                                                      16

<210>  4557
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4557
acaucaagga agaug                                                       15

<210>  4558
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4558
acaucaagga agat                                                        14

<210>  4559
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4559
acaucaagga aga                                                         13

<210>  4560
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4560
acaucaagga ag                                                          12

<210>  4561
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4561
caucaaggaa gauggcauuu cuag                                             24

<210>  4562
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4562
caucaaggaa gauggcauuu cua                                              23

<210>  4563
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4563
caucaaggaa gauggcauuu ct                                               22

<210>  4564
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4564
caucaaggaa gauggcauuu c                                                21

<210>  4565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4565
caucaaggaa gauggcauut                                                  20

<210>  4566
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4566
caucaaggaa gauggcaut                                                   19

<210>  4567
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4567
caucaaggaa gauggcat                                                    18

<210>  4568
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4568
caucaaggaa gauggca                                                     17

<210>  4569
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4569
caucaaggaa gauggc                                                      16

<210>  4570
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4570
caucaaggaa gaugg                                                       15

<210>  4571
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4571
caucaaggaa gaug                                                        14

<210>  4572
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4572
caucaaggaa gat                                                         13

<210>  4573
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4573
caucaaggaa ga                                                          12

<210>  4574
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4574
caucaaggaa g                                                           11

<210>  4575
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4575
aucaaggaag auggcauuuc uag                                              23

<210>  4576
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4576
aucaaggaag auggcauuuc ua                                               22

<210>  4577
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4577
aucaaggaag auggcauuuc t                                                21

<210>  4578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4578
aucaaggaag auggcauuuc                                                  20

<210>  4579
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4579
aucaaggaag auggcauut                                                   19

<210>  4580
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4580
aucaaggaag auggcaut                                                    18

<210>  4581
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4581
aucaaggaag auggcat                                                     17

<210>  4582
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4582
aucaaggaag auggca                                                      16

<210>  4583
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4583
aucaaggaag auggc                                                       15

<210>  4584
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4584
aucaaggaag augg                                                        14

<210>  4585
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4585
aucaaggaag aug                                                         13

<210>  4586
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4586
aucaaggaag at                                                          12

<210>  4587
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4587
aucaaggaag a                                                           11

<210>  4588
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4588
aucaaggaag                                                             10

<210>  4589
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4589
gguaaguucu guccaagc                                                    18

<210>  4590
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  4590
guaaguucug uccaagcc                                                    18

<210>  4591
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  4591
agucgguaag uucugucc                                                    18

<210>  4592
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4592
cuguccaagc ccgguuga                                                    18

<210>  4593
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4593
taaguucugu ccaag                                                       15

<210>  4594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4594
tucuguccaa gcccgguuga                                                  20

<210>  4595
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4595
tucuguccaa gcccgguug                                                   19

<210>  4596
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4596
tucuguccaa gcccggut                                                    18

<210>  4597
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4597
tucuguccaa gcccggt                                                     17

<210>  4598
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4598
tucuguccaa gcccgg                                                      16

<210>  4599
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4599
tucuguccaa gcccg                                                       15

<210>  4600
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4600
tucuguccaa gccc                                                        14

<210>  4601
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  4601
tucuguccaa gcc                                                         13

<210>  4602
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4602
tucuguccaa gc                                                          12

<210>  4603
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4603
tucuguccaa g                                                           11

<210>  4604
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4604
tucuguccaa                                                             10

<210>  4605
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4605
tucugucca                                                              9

<210>  4606
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4606
tucugucc                                                               8

<210>  4607
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4607
tcuguccaag cccgguuga                                                   19

<210>  4608
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4608
tcuguccaag cccgguug                                                    18

<210>  4609
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4609
tcuguccaag cccggut                                                     17

<210>  4610
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4610
tcuguccaag cccggt                                                      16

<210>  4611
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4611
tcuguccaag cccgg                                                       15

<210>  4612
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4612
tcuguccaag cccg                                                        14

<210>  4613
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4613
tcuguccaag ccc                                                         13

<210>  4614
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4614
tcuguccaag cc                                                          12

<210>  4615
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4615
tcuguccaag c                                                           11

<210>  4616
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  4616
tcuguccaag                                                             10

<210>  4617
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  4617
tcuguccaa                                                              9

<210>  4618
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  4618
tcugucca                                                               8

<210>  4619
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4619
cuguccaagc ccgguug                                                     17

<210>  4620
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4620
cuguccaagc ccggut                                                      16

<210>  4621
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4621
cuguccaagc ccggt                                                       15

<210>  4622
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4622
cuguccaagc ccgg                                                        14

<210>  4623
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4623
cuguccaagc ccg                                                         13

<210>  4624
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4624
cuguccaagc cc                                                          12

<210>  4625
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4625
cuguccaagc c                                                           11

<210>  4626
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4626
cuguccaagc                                                             10

<210>  4627
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4627
cuguccaag                                                              9

<210>  4628
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4628
cuguccaa                                                               8

<210>  4629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  4629
guucugucca agcccgguug                                                  20

<210>  4630
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  4630
guucugucca agcccggut                                                   19

<210>  4631
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  4631
guucugucca agcccggt                                                    18

<210>  4632
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  4632
guucugucca agcccgg                                                     17

<210>  4633
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  4633
guucugucca agcccg                                                      16

<210>  4634
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  4634
guucugucca agccc                                                       15

<210>  4635
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  4635
guucugucca agcc                                                        14

<210>  4636
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4636
guucugucca agc                                                         13

<210>  4637
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  4637
guucugucca ag                                                          12

<210>  4638
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  4638
guucugucca a                                                           11

<210>  4639
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  4639
guucugucca                                                             10

<210>  4640
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  4640
guucugucc                                                              9

<210>  4641
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4641
guucuguc                                                               8

<210>  4642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  4642
aguucugucc aagcccggut                                                  20

<210>  4643
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  4643
aguucugucc aagcccggt                                                   19

<210>  4644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  4644
aguucugucc aagcccgg                                                    18

<210>  4645
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  4645
aguucugucc aagcccg                                                     17

<210>  4646
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  4646
aguucugucc aagccc                                                      16

<210>  4647
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  4647
aguucugucc aagcc                                                       15

<210>  4648
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4648
aguucugucc aagc                                                        14

<210>  4649
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  4649
aguucugucc aag                                                         13

<210>  4650
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  4650
aguucugucc aa                                                          12

<210>  4651
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  4651
aguucugucc a                                                           11

<210>  4652
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  4652
aguucugucc                                                             10

<210>  4653
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4653
aguucuguc                                                              9

<210>  4654
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4654
aguucugt                                                               8

<210>  4655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  4655
aaguucuguc caagcccggt                                                  20

<210>  4656
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  4656
aaguucuguc caagcccgg                                                   19

<210>  4657
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  4657
aaguucuguc caagcccg                                                    18

<210>  4658
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  4658
aaguucuguc caagccc                                                     17

<210>  4659
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  4659
aaguucuguc caagcc                                                      16

<210>  4660
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4660
aaguucuguc caagc                                                       15

<210>  4661
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  4661
aaguucuguc caag                                                        14

<210>  4662
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  4662
aaguucuguc caa                                                         13

<210>  4663
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  4663
aaguucuguc ca                                                          12

<210>  4664
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  4664
aaguucuguc c                                                           11

<210>  4665
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4665
aaguucuguc                                                             10

<210>  4666
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4666
aaguucugt                                                              9

<210>  4667
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4667
aaguucug                                                               8

<210>  4668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  4668
taaguucugu ccaagcccgg                                                  20

<210>  4669
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  4669
taaguucugu ccaagcccg                                                   19

<210>  4670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  4670
taaguucugu ccaagccc                                                    18

<210>  4671
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  4671
taaguucugu ccaagcc                                                     17

<210>  4672
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4672
taaguucugu ccaagc                                                      16

<210>  4673
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4673
taaguucugu ccaa                                                        14

<210>  4674
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4674
taaguucugu cca                                                         13

<210>  4675
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4675
taaguucugu cc                                                          12

<210>  4676
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4676
taaguucugu c                                                           11

<210>  4677
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4677
taaguucugt                                                             10

<210>  4678
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4678
taaguucug                                                              9

<210>  4679
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4679
taaguuct                                                               8

<210>  4680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  4680
guaaguucug uccaagcccg                                                  20

<210>  4681
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  4681
guaaguucug uccaagccc                                                   19

<210>  4682
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4682
guaaguucug uccaagc                                                     17

<210>  4683
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  4683
guaaguucug uccaag                                                      16

<210>  4684
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  4684
guaaguucug uccaa                                                       15

<210>  4685
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  4685
guaaguucug ucca                                                        14

<210>  4686
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  4686
guaaguucug ucc                                                         13

<210>  4687
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4687
guaaguucug uc                                                          12

<210>  4688
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4688
guaaguucug t                                                           11

<210>  4689
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4689
guaaguucug                                                             10

<210>  4690
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4690
guaaguuct                                                              9

<210>  4691
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4691
guaaguuc                                                               8

<210>  4692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  4692
gguaaguucu guccaagccc                                                  20

<210>  4693
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  4693
gguaaguucu guccaagcc                                                   19

<210>  4694
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  4694
gguaaguucu guccaag                                                     17

<210>  4695
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  4695
gguaaguucu guccaa                                                      16

<210>  4696
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  4696
gguaaguucu gucca                                                       15

<210>  4697
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  4697
gguaaguucu gucc                                                        14

<210>  4698
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4698
gguaaguucu guc                                                         13

<210>  4699
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4699
gguaaguucu gt                                                          12

<210>  4700
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4700
gguaaguucu g                                                           11

<210>  4701
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4701
gguaaguuct                                                             10

<210>  4702
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4702
gguaaguuc                                                              9

<210>  4703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4703
cgguaaguuc uguccaagcc                                                  20

<210>  4704
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4704
cgguaaguuc uguccaagc                                                   19

<210>  4705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4705
cgguaaguuc uguccaag                                                    18

<210>  4706
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4706
cgguaaguuc uguccaa                                                     17

<210>  4707
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4707
cgguaaguuc ugucca                                                      16

<210>  4708
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4708
cgguaaguuc ugucc                                                       15

<210>  4709
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4709
cgguaaguuc uguc                                                        14

<210>  4710
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4710
cgguaaguuc ugt                                                         13

<210>  4711
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4711
cgguaaguuc ug                                                          12

<210>  4712
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4712
cgguaaguuc t                                                           11

<210>  4713
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4713
cgguaaguuc                                                             10

<210>  4714
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4714
cgguaagut                                                              9

<210>  4715
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4715
cgguaagt                                                               8

<210>  4716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4716
tcgguaaguu cuguccaagc                                                  20

<210>  4717
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  4717
tcgguaaguu cuguccaag                                                   19

<210>  4718
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  4718
tcgguaaguu cuguccaa                                                    18

<210>  4719
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  4719
tcgguaaguu cugucca                                                     17

<210>  4720
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  4720
tcgguaaguu cugucc                                                      16

<210>  4721
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4721
tcgguaaguu cuguc                                                       15

<210>  4722
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4722
tcgguaaguu cugt                                                        14

<210>  4723
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4723
tcgguaaguu cug                                                         13

<210>  4724
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4724
tcgguaaguu ct                                                          12

<210>  4725
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4725
tcgguaaguu c                                                           11

<210>  4726
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4726
tcgguaagut                                                             10

<210>  4727
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4727
tcgguaagt                                                              9

<210>  4728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  4728
gucgguaagu ucuguccaag                                                  20

<210>  4729
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  4729
gucgguaagu ucuguccaa                                                   19

<210>  4730
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  4730
gucgguaagu ucugucca                                                    18

<210>  4731
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  4731
gucgguaagu ucugucc                                                     17

<210>  4732
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4732
gucgguaagu ucuguc                                                      16

<210>  4733
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4733
gucgguaagu ucugt                                                       15

<210>  4734
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4734
gucgguaagu ucug                                                        14

<210>  4735
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4735
gucgguaagu uct                                                         13

<210>  4736
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4736
gucgguaagu uc                                                          12

<210>  4737
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4737
gucgguaagu t                                                           11

<210>  4738
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4738
gucgguaagt                                                             10

<210>  4739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  4739
agucgguaag uucuguccaa                                                  20

<210>  4740
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  4740
agucgguaag uucugucca                                                   19

<210>  4741
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4741
agucgguaag uucuguc                                                     17

<210>  4742
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4742
agucgguaag uucugt                                                      16

<210>  4743
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4743
agucgguaag uucug                                                       15

<210>  4744
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4744
agucgguaag uuct                                                        14

<210>  4745
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4745
agucgguaag uuc                                                         13

<210>  4746
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  4746
agucgguaag ut                                                          12

<210>  4747
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  4747
agucgguaag t                                                           11

<210>  4748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4748
cagucgguaa guucugucca                                                  20

<210>  4749
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4749
cagucgguaa guucugucc                                                   19

<210>  4750
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4750
cagucgguaa guucuguc                                                    18

<210>  4751
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4751
cagucgguaa guucugt                                                     17

<210>  4752
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4752
cagucgguaa guucug                                                      16

<210>  4753
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4753
cagucgguaa guuct                                                       15

<210>  4754
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4754
cagucgguaa guuc                                                        14

<210>  4755
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4755
cagucgguaa gut                                                         13

<210>  4756
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4756
cagucgguaa gt                                                          12

<210>  4757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4757
ccagucggua aguucugucc                                                  20

<210>  4758
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4758
ccagucggua aguucuguc                                                   19

<210>  4759
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4759
ccagucggua aguucugt                                                    18

<210>  4760
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4760
ccagucggua aguucug                                                     17

<210>  4761
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4761
ccagucggua aguuct                                                      16

<210>  4762
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4762
ccagucggua aguuc                                                       15

<210>  4763
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4763
ccagucggua agut                                                        14

<210>  4764
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4764
ccagucggua agt                                                         13

<210>  4765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4765
gccagucggu aaguucuguc                                                  20

<210>  4766
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4766
gccagucggu aaguucugt                                                   19

<210>  4767
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4767
gccagucggu aaguucug                                                    18

<210>  4768
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4768
gccagucggu aaguuct                                                     17

<210>  4769
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4769
gccagucggu aaguuc                                                      16

<210>  4770
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4770
gccagucggu aagut                                                       15

<210>  4771
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4771
gccagucggu aagt                                                        14

<210>  4772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4772
tcaaggaaga uggcauuuct                                                  20

<210>  4773
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4773
tcaaggaaga uggcauuucu ag                                               22

<210>  4774
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4774
tcaaggaaga uggcat                                                      16

<210>  4775
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4775
gaagauggca uuuct                                                       15

<210>  4776
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4776
tcaaggaaga uggcauuucu a                                                21

<210>  4777
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  4777
tcaaggaaga uggcauuuc                                                   19

<210>  4778
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4778
tcaaggaaga uggcauut                                                    18

<210>  4779
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4779
tcaaggaaga uggcaut                                                     17

<210>  4780
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4780
tcaaggaaga uggca                                                       15

<210>  4781
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4781
tcaaggaaga uggc                                                        14

<210>  4782
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4782
tcaaggaaga ugg                                                         13

<210>  4783
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4783
tcaaggaaga ug                                                          12

<210>  4784
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4784
tcaaggaaga t                                                           11

<210>  4785
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4785
tcaaggaaga                                                             10

<210>  4786
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  4786
tcaaggaag                                                              9

<210>  4787
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4787
caaggaagau ggcauuucua g                                                21

<210>  4788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4788
caaggaagau ggcauuucua                                                  20

<210>  4789
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4789
caaggaagau ggcauuuct                                                   19

<210>  4790
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4790
caaggaagau ggcauuuc                                                    18

<210>  4791
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4791
caaggaagau ggcauut                                                     17

<210>  4792
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4792
caaggaagau ggcaut                                                      16

<210>  4793
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4793
caaggaagau ggcat                                                       15

<210>  4794
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4794
caaggaagau ggca                                                        14

<210>  4795
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4795
caaggaagau ggc                                                         13

<210>  4796
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4796
caaggaagau gg                                                          12

<210>  4797
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4797
caaggaagau g                                                           11

<210>  4798
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  4798
caaggaagat                                                             10

<210>  4799
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  4799
caaggaaga                                                              9

<210>  4800
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  4800
caaggaag                                                               8

<210>  4801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4801
aaggaagaug gcauuucuag                                                  20

<210>  4802
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4802
aaggaagaug gcauuucua                                                   19

<210>  4803
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4803
aaggaagaug gcauuuct                                                    18

<210>  4804
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4804
aaggaagaug gcauuuc                                                     17

<210>  4805
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4805
aaggaagaug gcauut                                                      16

<210>  4806
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4806
aaggaagaug gcaut                                                       15

<210>  4807
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4807
aaggaagaug gcat                                                        14

<210>  4808
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4808
aaggaagaug gca                                                         13

<210>  4809
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4809
aaggaagaug gc                                                          12

<210>  4810
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4810
aggaagaugg cauuucuag                                                   19

<210>  4811
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4811
aggaagaugg cauuucua                                                    18

<210>  4812
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4812
aggaagaugg cauuuct                                                     17

<210>  4813
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  4813
aggaagaugg cauuuc                                                      16

<210>  4814
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4814
aggaagaugg cauut                                                       15

<210>  4815
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4815
aggaagaugg caut                                                        14

<210>  4816
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4816
aggaagaugg cat                                                         13

<210>  4817
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4817
aggaagaugg ca                                                          12

<210>  4818
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4818
ggaagauggc auuucuag                                                    18

<210>  4819
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4819
ggaagauggc auuucua                                                     17

<210>  4820
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4820
ggaagauggc auuuct                                                      16

<210>  4821
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4821
ggaagauggc auuuc                                                       15

<210>  4822
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4822
ggaagauggc auut                                                        14

<210>  4823
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4823
ggaagauggc aut                                                         13

<210>  4824
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4824
ggaagauggc at                                                          12

<210>  4825
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4825
ggaagauggc a                                                           11

<210>  4826
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  4826
ggaagauggc                                                             10

<210>  4827
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4827
gaagauggca uuucuag                                                     17

<210>  4828
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4828
gaagauggca uuucua                                                      16

<210>  4829
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  4829
gaagauggca uuuc                                                        14

<210>  4830
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4830
gaagauggca uut                                                         13

<210>  4831
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4831
gaagauggca ut                                                          12

<210>  4832
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4832
gaagauggca t                                                           11

<210>  4833
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4833
gaagauggca                                                             10

<210>  4834
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4834
gaagauggc                                                              9

<210>  4835
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4835
aagauggcau uucuag                                                      16

<210>  4836
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4836
aagauggcau uucua                                                       15

<210>  4837
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4837
aagauggcau uuct                                                        14

<210>  4838
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  4838
aagauggcau uuc                                                         13

<210>  4839
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4839
aagauggcau ut                                                          12

<210>  4840
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4840
aagauggcau t                                                           11

<210>  4841
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4841
aagauggcat                                                             10

<210>  4842
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4842
aagauggca                                                              9

<210>  4843
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  4843
aagauggc                                                               8

<210>  4844
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4844
agauggcauu ucuag                                                       15

<210>  4845
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4845
agauggcauu ucua                                                        14

<210>  4846
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4846
agauggcauu uct                                                         13

<210>  4847
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4847
agauggcauu uc                                                          12

<210>  4848
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4848
agauggcauu t                                                           11

<210>  4849
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4849
agauggcaut                                                             10

<210>  4850
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4850
agauggcat                                                              9

<210>  4851
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  4851
agauggca                                                               8

<210>  4852
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  4852
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  4853
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  4853
cuccaacauc aaggaagaug gcauuucua                                        29

<210>  4854
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  4854
cuccaacauc aaggaagaug gcauuuct                                         28

<210>  4855
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4855
cuccaacauc aaggaagaug gcauuuc                                          27

<210>  4856
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4856
cuccaacauc aaggaagaug gcauut                                           26

<210>  4857
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4857
cuccaacauc aaggaagaug gcaut                                            25

<210>  4858
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4858
cuccaacauc aaggaagaug gcat                                             24

<210>  4859
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4859
cuccaacauc aaggaagaug gca                                              23

<210>  4860
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4860
cuccaacauc aaggaagaug gc                                               22

<210>  4861
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4861
cuccaacauc aaggaagaug g                                                21

<210>  4862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4862
cuccaacauc aaggaagaug                                                  20

<210>  4863
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4863
cuccaacauc aaggaagat                                                   19

<210>  4864
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4864
cuccaacauc aaggaaga                                                    18

<210>  4865
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4865
cuccaacauc aaggaag                                                     17

<210>  4866
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4866
tccaacauca aggaagaugg cauuucuag                                        29

<210>  4867
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4867
tccaacauca aggaagaugg cauuucua                                         28

<210>  4868
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4868
tccaacauca aggaagaugg cauuuct                                          27

<210>  4869
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  4869
tccaacauca aggaagaugg cauuuc                                           26

<210>  4870
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4870
tccaacauca aggaagaugg cauut                                            25

<210>  4871
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4871
tccaacauca aggaagaugg caut                                             24

<210>  4872
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4872
tccaacauca aggaagaugg cat                                              23

<210>  4873
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4873
tccaacauca aggaagaugg ca                                               22

<210>  4874
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  4874
tccaacauca aggaagaugg c                                                21

<210>  4875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4875
tccaacauca aggaagaugg                                                  20

<210>  4876
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4876
tccaacauca aggaagaug                                                   19

<210>  4877
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4877
tccaacauca aggaagat                                                    18

<210>  4878
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4878
tccaacauca aggaaga                                                     17

<210>  4879
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  4879
tccaacauca aggaag                                                      16

<210>  4880
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  4880
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  4881
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4881
ccaacaucaa ggaagauggc auuucua                                          27

<210>  4882
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4882
ccaacaucaa ggaagauggc auuuct                                           26

<210>  4883
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4883
ccaacaucaa ggaagauggc auuuc                                            25

<210>  4884
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4884
ccaacaucaa ggaagauggc auut                                             24

<210>  4885
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4885
ccaacaucaa ggaagauggc aut                                              23

<210>  4886
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4886
ccaacaucaa ggaagauggc at                                               22

<210>  4887
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4887
ccaacaucaa ggaagauggc a                                                21

<210>  4888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4888
ccaacaucaa ggaagauggc                                                  20

<210>  4889
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4889
ccaacaucaa ggaagaugg                                                   19

<210>  4890
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4890
ccaacaucaa ggaagaug                                                    18

<210>  4891
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4891
ccaacaucaa ggaagat                                                     17

<210>  4892
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4892
ccaacaucaa ggaaga                                                      16

<210>  4893
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4893
ccaacaucaa ggaag                                                       15

<210>  4894
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  4894
caacaucaag gaagauggca uuucuag                                          27

<210>  4895
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  4895
caacaucaag gaagauggca uuucua                                           26

<210>  4896
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  4896
caacaucaag gaagauggca uuuct                                            25

<210>  4897
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4897
caacaucaag gaagauggca uuuc                                             24

<210>  4898
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4898
caacaucaag gaagauggca uut                                              23

<210>  4899
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4899
caacaucaag gaagauggca ut                                               22

<210>  4900
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4900
caacaucaag gaagauggca t                                                21

<210>  4901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4901
caacaucaag gaagauggca                                                  20

<210>  4902
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4902
caacaucaag gaagauggc                                                   19

<210>  4903
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4903
caacaucaag gaagaugg                                                    18

<210>  4904
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4904
caacaucaag gaagaug                                                     17

<210>  4905
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4905
caacaucaag gaagat                                                      16

<210>  4906
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4906
caacaucaag gaaga                                                       15

<210>  4907
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4907
caacaucaag gaag                                                        14

<210>  4908
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4908
aacaucaagg aagauggcau uucuag                                           26

<210>  4909
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4909
aacaucaagg aagauggcau uucua                                            25

<210>  4910
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4910
aacaucaagg aagauggcau uuct                                             24

<210>  4911
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  4911
aacaucaagg aagauggcau uuc                                              23

<210>  4912
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4912
aacaucaagg aagauggcau ut                                               22

<210>  4913
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4913
aacaucaagg aagauggcau t                                                21

<210>  4914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4914
aacaucaagg aagauggcat                                                  20

<210>  4915
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4915
aacaucaagg aagauggca                                                   19

<210>  4916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4916
aacaucaagg aagauggc                                                    18

<210>  4917
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4917
aacaucaagg aagaugg                                                     17

<210>  4918
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4918
aacaucaagg aagaug                                                      16

<210>  4919
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4919
aacaucaagg aagat                                                       15

<210>  4920
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4920
aacaucaagg aaga                                                        14

<210>  4921
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  4921
aacaucaagg aag                                                         13

<210>  4922
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4922
acaucaagga agauggcauu ucuag                                            25

<210>  4923
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4923
acaucaagga agauggcauu ucua                                             24

<210>  4924
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4924
acaucaagga agauggcauu uct                                              23

<210>  4925
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  4925
acaucaagga agauggcauu uc                                               22

<210>  4926
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4926
acaucaagga agauggcauu t                                                21

<210>  4927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4927
acaucaagga agauggcaut                                                  20

<210>  4928
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4928
acaucaagga agauggcat                                                   19

<210>  4929
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4929
acaucaagga agauggca                                                    18

<210>  4930
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  4930
acaucaagga agauggc                                                     17

<210>  4931
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4931
acaucaagga agaugg                                                      16

<210>  4932
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4932
acaucaagga agaug                                                       15

<210>  4933
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4933
acaucaagga agat                                                        14

<210>  4934
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4934
acaucaagga aga                                                         13

<210>  4935
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  4935
acaucaagga ag                                                          12

<210>  4936
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  4936
caucaaggaa gauggcauuu cuag                                             24

<210>  4937
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  4937
caucaaggaa gauggcauuu cua                                              23

<210>  4938
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  4938
caucaaggaa gauggcauuu ct                                               22

<210>  4939
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  4939
caucaaggaa gauggcauuu c                                                21

<210>  4940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  4940
caucaaggaa gauggcauut                                                  20

<210>  4941
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  4941
caucaaggaa gauggcaut                                                   19

<210>  4942
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  4942
caucaaggaa gauggcat                                                    18

<210>  4943
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  4943
caucaaggaa gauggca                                                     17

<210>  4944
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  4944
caucaaggaa gauggc                                                      16

<210>  4945
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  4945
caucaaggaa gaugg                                                       15

<210>  4946
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  4946
caucaaggaa gaug                                                        14

<210>  4947
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  4947
caucaaggaa gat                                                         13

<210>  4948
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  4948
caucaaggaa ga                                                          12

<210>  4949
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  4949
caucaaggaa g                                                           11

<210>  4950
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4950
aucaaggaag auggcauuuc uag                                              23

<210>  4951
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4951
aucaaggaag auggcauuuc ua                                               22

<210>  4952
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4952
aucaaggaag auggcauuuc t                                                21

<210>  4953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  4953
aucaaggaag auggcauuuc                                                  20

<210>  4954
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4954
aucaaggaag auggcauut                                                   19

<210>  4955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4955
aucaaggaag auggcaut                                                    18

<210>  4956
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4956
aucaaggaag auggcat                                                     17

<210>  4957
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4957
aucaaggaag auggca                                                      16

<210>  4958
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  4958
aucaaggaag auggc                                                       15

<210>  4959
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4959
aucaaggaag augg                                                        14

<210>  4960
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4960
aucaaggaag aug                                                         13

<210>  4961
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4961
aucaaggaag at                                                          12

<210>  4962
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4962
aucaaggaag a                                                           11

<210>  4963
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  4963
aucaaggaag                                                             10

<210>  4964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  4964
gguaaguucu guccaagc                                                    18

<210>  4965
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  4965
gtaaguucug uccaagcc                                                    18

<210>  4966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  4966
agucgguaag uucugucc                                                    18

<210>  4967
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4967
ctguccaagc ccgguuga                                                    18

<210>  4968
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4968
taaguucugu ccaag                                                       15

<210>  4969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4969
ttcuguccaa gcccgguuga                                                  20

<210>  4970
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4970
ttcuguccaa gcccgguug                                                   19

<210>  4971
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4971
ttcuguccaa gcccgguu                                                    18

<210>  4972
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4972
ttcuguccaa gcccggu                                                     17

<210>  4973
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4973
ttcuguccaa gcccgg                                                      16

<210>  4974
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4974
ttcuguccaa gcccg                                                       15

<210>  4975
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  4975
ttcuguccaa gccc                                                        14

<210>  4976
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  4976
ttcuguccaa gcc                                                         13

<210>  4977
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  4977
ttcuguccaa gc                                                          12

<210>  4978
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4978
ttcuguccaa g                                                           11

<210>  4979
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4979
ttcuguccaa                                                             10

<210>  4980
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4980
ttcugucca                                                              9

<210>  4981
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  4981
ttcugucc                                                               8

<210>  4982
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4982
tcuguccaag cccgguuga                                                   19

<210>  4983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4983
tcuguccaag cccgguug                                                    18

<210>  4984
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4984
tcuguccaag cccgguu                                                     17

<210>  4985
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4985
tcuguccaag cccggu                                                      16

<210>  4986
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4986
tcuguccaag cccgg                                                       15

<210>  4987
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4987
tcuguccaag cccg                                                        14

<210>  4988
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  4988
tcuguccaag ccc                                                         13

<210>  4989
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  4989
tcuguccaag cc                                                          12

<210>  4990
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  4990
tcuguccaag c                                                           11

<210>  4991
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  4991
tcuguccaag                                                             10

<210>  4992
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  4992
tcuguccaa                                                              9

<210>  4993
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  4993
tcugucca                                                               8

<210>  4994
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4994
ctguccaagc ccgguug                                                     17

<210>  4995
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4995
ctguccaagc ccgguu                                                      16

<210>  4996
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4996
ctguccaagc ccggu                                                       15

<210>  4997
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4997
ctguccaagc ccgg                                                        14

<210>  4998
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4998
ctguccaagc ccg                                                         13

<210>  4999
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  4999
ctguccaagc cc                                                          12

<210>  5000
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5000
ctguccaagc c                                                           11

<210>  5001
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5001
ctguccaagc                                                             10

<210>  5002
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5002
ctguccaag                                                              9

<210>  5003
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5003
ctguccaa                                                               8

<210>  5004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5004
gtucugucca agcccgguug                                                  20

<210>  5005
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5005
gtucugucca agcccgguu                                                   19

<210>  5006
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5006
gtucugucca agcccggu                                                    18

<210>  5007
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5007
gtucugucca agcccgg                                                     17

<210>  5008
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5008
gtucugucca agcccg                                                      16

<210>  5009
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5009
gtucugucca agccc                                                       15

<210>  5010
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5010
gtucugucca agcc                                                        14

<210>  5011
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5011
gtucugucca agc                                                         13

<210>  5012
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5012
gtucugucca ag                                                          12

<210>  5013
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5013
gtucugucca a                                                           11

<210>  5014
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5014
gtucugucca                                                             10

<210>  5015
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5015
gtucugucc                                                              9

<210>  5016
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5016
gtucuguc                                                               8

<210>  5017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5017
aguucugucc aagcccgguu                                                  20

<210>  5018
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5018
aguucugucc aagcccggu                                                   19

<210>  5019
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5019
aguucugucc aagcccgg                                                    18

<210>  5020
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5020
aguucugucc aagcccg                                                     17

<210>  5021
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5021
aguucugucc aagccc                                                      16

<210>  5022
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  5022
aguucugucc aagcc                                                       15

<210>  5023
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5023
aguucugucc aagc                                                        14

<210>  5024
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5024
aguucugucc aag                                                         13

<210>  5025
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5025
aguucugucc aa                                                          12

<210>  5026
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5026
aguucugucc a                                                           11

<210>  5027
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5027
aguucugucc                                                             10

<210>  5028
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5028
aguucuguc                                                              9

<210>  5029
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5029
aguucugu                                                               8

<210>  5030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5030
aaguucuguc caagcccggu                                                  20

<210>  5031
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5031
aaguucuguc caagcccgg                                                   19

<210>  5032
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5032
aaguucuguc caagcccg                                                    18

<210>  5033
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5033
aaguucuguc caagccc                                                     17

<210>  5034
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5034
aaguucuguc caagcc                                                      16

<210>  5035
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5035
aaguucuguc caagc                                                       15

<210>  5036
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5036
aaguucuguc caag                                                        14

<210>  5037
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5037
aaguucuguc caa                                                         13

<210>  5038
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5038
aaguucuguc ca                                                          12

<210>  5039
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5039
aaguucuguc c                                                           11

<210>  5040
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5040
aaguucuguc                                                             10

<210>  5041
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5041
aaguucugu                                                              9

<210>  5042
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5042
aaguucug                                                               8

<210>  5043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  5043
taaguucugu ccaagcccgg                                                  20

<210>  5044
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  5044
taaguucugu ccaagcccg                                                   19

<210>  5045
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  5045
taaguucugu ccaagccc                                                    18

<210>  5046
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5046
taaguucugu ccaagcc                                                     17

<210>  5047
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5047
taaguucugu ccaagc                                                      16

<210>  5048
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5048
taaguucugu ccaa                                                        14

<210>  5049
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5049
taaguucugu cca                                                         13

<210>  5050
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5050
taaguucugu cc                                                          12

<210>  5051
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5051
taaguucugu c                                                           11

<210>  5052
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5052
taaguucugu                                                             10

<210>  5053
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5053
taaguucug                                                              9

<210>  5054
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5054
taaguucu                                                               8

<210>  5055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  5055
gtaaguucug uccaagcccg                                                  20

<210>  5056
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  5056
gtaaguucug uccaagccc                                                   19

<210>  5057
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5057
gtaaguucug uccaagc                                                     17

<210>  5058
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5058
gtaaguucug uccaag                                                      16

<210>  5059
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5059
gtaaguucug uccaa                                                       15

<210>  5060
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5060
gtaaguucug ucca                                                        14

<210>  5061
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5061
gtaaguucug ucc                                                         13

<210>  5062
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5062
gtaaguucug uc                                                          12

<210>  5063
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5063
gtaaguucug u                                                           11

<210>  5064
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5064
gtaaguucug                                                             10

<210>  5065
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5065
gtaaguucu                                                              9

<210>  5066
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5066
gtaaguuc                                                               8

<210>  5067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  5067
gguaaguucu guccaagccc                                                  20

<210>  5068
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  5068
gguaaguucu guccaagcc                                                   19

<210>  5069
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5069
gguaaguucu guccaag                                                     17

<210>  5070
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5070
gguaaguucu guccaa                                                      16

<210>  5071
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5071
gguaaguucu gucca                                                       15

<210>  5072
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5072
gguaaguucu gucc                                                        14

<210>  5073
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5073
gguaaguucu guc                                                         13

<210>  5074
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5074
gguaaguucu gu                                                          12

<210>  5075
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5075
gguaaguucu g                                                           11

<210>  5076
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5076
gguaaguucu                                                             10

<210>  5077
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5077
gguaaguuc                                                              9

<210>  5078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5078
cgguaaguuc uguccaagcc                                                  20

<210>  5079
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5079
cgguaaguuc uguccaagc                                                   19

<210>  5080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5080
cgguaaguuc uguccaag                                                    18

<210>  5081
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5081
cgguaaguuc uguccaa                                                     17

<210>  5082
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5082
cgguaaguuc ugucca                                                      16

<210>  5083
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5083
cgguaaguuc ugucc                                                       15

<210>  5084
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5084
cgguaaguuc uguc                                                        14

<210>  5085
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5085
cgguaaguuc ugu                                                         13

<210>  5086
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5086
cgguaaguuc ug                                                          12

<210>  5087
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5087
cgguaaguuc u                                                           11

<210>  5088
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5088
cgguaaguuc                                                             10

<210>  5089
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5089
cgguaaguu                                                              9

<210>  5090
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5090
cgguaagu                                                               8

<210>  5091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5091
tcgguaaguu cuguccaagc                                                  20

<210>  5092
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5092
tcgguaaguu cuguccaag                                                   19

<210>  5093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5093
tcgguaaguu cuguccaa                                                    18

<210>  5094
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5094
tcgguaaguu cugucca                                                     17

<210>  5095
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5095
tcgguaaguu cugucc                                                      16

<210>  5096
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5096
tcgguaaguu cuguc                                                       15

<210>  5097
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5097
tcgguaaguu cugu                                                        14

<210>  5098
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5098
tcgguaaguu cug                                                         13

<210>  5099
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5099
tcgguaaguu cu                                                          12

<210>  5100
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5100
tcgguaaguu c                                                           11

<210>  5101
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5101
tcgguaaguu                                                             10

<210>  5102
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5102
tcgguaagu                                                              9

<210>  5103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5103
gtcgguaagu ucuguccaag                                                  20

<210>  5104
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5104
gtcgguaagu ucuguccaa                                                   19

<210>  5105
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5105
gtcgguaagu ucugucca                                                    18

<210>  5106
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5106
gtcgguaagu ucugucc                                                     17

<210>  5107
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5107
gtcgguaagu ucuguc                                                      16

<210>  5108
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5108
gtcgguaagu ucugu                                                       15

<210>  5109
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5109
gtcgguaagu ucug                                                        14

<210>  5110
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5110
gtcgguaagu ucu                                                         13

<210>  5111
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5111
gtcgguaagu uc                                                          12

<210>  5112
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5112
gtcgguaagu u                                                           11

<210>  5113
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5113
gtcgguaagu                                                             10

<210>  5114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  5114
agucgguaag uucuguccaa                                                  20

<210>  5115
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  5115
agucgguaag uucugucca                                                   19

<210>  5116
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5116
agucgguaag uucuguc                                                     17

<210>  5117
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5117
agucgguaag uucugu                                                      16

<210>  5118
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5118
agucgguaag uucug                                                       15

<210>  5119
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5119
agucgguaag uucu                                                        14

<210>  5120
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5120
agucgguaag uuc                                                         13

<210>  5121
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  5121
agucgguaag uu                                                          12

<210>  5122
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  5122
agucgguaag u                                                           11

<210>  5123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5123
cagucgguaa guucugucca                                                  20

<210>  5124
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5124
cagucgguaa guucugucc                                                   19

<210>  5125
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5125
cagucgguaa guucuguc                                                    18

<210>  5126
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5126
cagucgguaa guucugu                                                     17

<210>  5127
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5127
cagucgguaa guucug                                                      16

<210>  5128
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5128
cagucgguaa guucu                                                       15

<210>  5129
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5129
cagucgguaa guuc                                                        14

<210>  5130
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5130
cagucgguaa guu                                                         13

<210>  5131
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5131
cagucgguaa gu                                                          12

<210>  5132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5132
ccagucggua aguucugucc                                                  20

<210>  5133
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5133
ccagucggua aguucuguc                                                   19

<210>  5134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5134
ccagucggua aguucugu                                                    18

<210>  5135
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5135
ccagucggua aguucug                                                     17

<210>  5136
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5136
ccagucggua aguucu                                                      16

<210>  5137
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5137
ccagucggua aguuc                                                       15

<210>  5138
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5138
ccagucggua aguu                                                        14

<210>  5139
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5139
ccagucggua agu                                                         13

<210>  5140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5140
gccagucggu aaguucuguc                                                  20

<210>  5141
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5141
gccagucggu aaguucugu                                                   19

<210>  5142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5142
gccagucggu aaguucug                                                    18

<210>  5143
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5143
gccagucggu aaguucu                                                     17

<210>  5144
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5144
gccagucggu aaguuc                                                      16

<210>  5145
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5145
gccagucggu aaguu                                                       15

<210>  5146
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5146
gccagucggu aagu                                                        14

<210>  5147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5147
tcaaggaaga uggcauuucu                                                  20

<210>  5148
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5148
tcaaggaaga uggcauuucu ag                                               22

<210>  5149
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5149
tcaaggaaga uggcau                                                      16

<210>  5150
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5150
gaagauggca uuucu                                                       15

<210>  5151
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5151
tcaaggaaga uggcauuucu a                                                21

<210>  5152
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5152
tcaaggaaga uggcauuuc                                                   19

<210>  5153
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5153
tcaaggaaga uggcauuu                                                    18

<210>  5154
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5154
tcaaggaaga uggcauu                                                     17

<210>  5155
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5155
tcaaggaaga uggca                                                       15

<210>  5156
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5156
tcaaggaaga uggc                                                        14

<210>  5157
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5157
tcaaggaaga ugg                                                         13

<210>  5158
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5158
tcaaggaaga ug                                                          12

<210>  5159
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5159
tcaaggaaga u                                                           11

<210>  5160
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5160
tcaaggaaga                                                             10

<210>  5161
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5161
tcaaggaag                                                              9

<210>  5162
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5162
caaggaagau ggcauuucua g                                                21

<210>  5163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5163
caaggaagau ggcauuucua                                                  20

<210>  5164
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5164
caaggaagau ggcauuucu                                                   19

<210>  5165
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5165
caaggaagau ggcauuuc                                                    18

<210>  5166
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5166
caaggaagau ggcauuu                                                     17

<210>  5167
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5167
caaggaagau ggcauu                                                      16

<210>  5168
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5168
caaggaagau ggcau                                                       15

<210>  5169
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5169
caaggaagau ggca                                                        14

<210>  5170
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5170
caaggaagau ggc                                                         13

<210>  5171
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5171
caaggaagau gg                                                          12

<210>  5172
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5172
caaggaagau g                                                           11

<210>  5173
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5173
caaggaagau                                                             10

<210>  5174
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5174
caaggaaga                                                              9

<210>  5175
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5175
caaggaag                                                               8

<210>  5176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5176
aaggaagaug gcauuucuag                                                  20

<210>  5177
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5177
aaggaagaug gcauuucua                                                   19

<210>  5178
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5178
aaggaagaug gcauuucu                                                    18

<210>  5179
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5179
aaggaagaug gcauuuc                                                     17

<210>  5180
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5180
aaggaagaug gcauuu                                                      16

<210>  5181
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5181
aaggaagaug gcauu                                                       15

<210>  5182
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5182
aaggaagaug gcau                                                        14

<210>  5183
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5183
aaggaagaug gca                                                         13

<210>  5184
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5184
aaggaagaug gc                                                          12

<210>  5185
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5185
aggaagaugg cauuucuag                                                   19

<210>  5186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5186
aggaagaugg cauuucua                                                    18

<210>  5187
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5187
aggaagaugg cauuucu                                                     17

<210>  5188
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5188
aggaagaugg cauuuc                                                      16

<210>  5189
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5189
aggaagaugg cauuu                                                       15

<210>  5190
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5190
aggaagaugg cauu                                                        14

<210>  5191
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5191
aggaagaugg cau                                                         13

<210>  5192
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5192
aggaagaugg ca                                                          12

<210>  5193
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5193
ggaagauggc auuucuag                                                    18

<210>  5194
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5194
ggaagauggc auuucua                                                     17

<210>  5195
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5195
ggaagauggc auuucu                                                      16

<210>  5196
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5196
ggaagauggc auuuc                                                       15

<210>  5197
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5197
ggaagauggc auuu                                                        14

<210>  5198
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5198
ggaagauggc auu                                                         13

<210>  5199
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5199
ggaagauggc au                                                          12

<210>  5200
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5200
ggaagauggc a                                                           11

<210>  5201
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5201
ggaagauggc                                                             10

<210>  5202
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5202
gaagauggca uuucuag                                                     17

<210>  5203
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5203
gaagauggca uuucua                                                      16

<210>  5204
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5204
gaagauggca uuuc                                                        14

<210>  5205
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5205
gaagauggca uuu                                                         13

<210>  5206
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5206
gaagauggca uu                                                          12

<210>  5207
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5207
gaagauggca u                                                           11

<210>  5208
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5208
gaagauggca                                                             10

<210>  5209
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5209
gaagauggc                                                              9

<210>  5210
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5210
aagauggcau uucuag                                                      16

<210>  5211
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5211
aagauggcau uucua                                                       15

<210>  5212
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5212
aagauggcau uucu                                                        14

<210>  5213
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5213
aagauggcau uuc                                                         13

<210>  5214
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5214
aagauggcau uu                                                          12

<210>  5215
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5215
aagauggcau u                                                           11

<210>  5216
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5216
aagauggcau                                                             10

<210>  5217
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5217
aagauggca                                                              9

<210>  5218
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5218
aagauggc                                                               8

<210>  5219
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5219
agauggcauu ucuag                                                       15

<210>  5220
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5220
agauggcauu ucua                                                        14

<210>  5221
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5221
agauggcauu ucu                                                         13

<210>  5222
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5222
agauggcauu uc                                                          12

<210>  5223
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5223
agauggcauu u                                                           11

<210>  5224
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5224
agauggcauu                                                             10

<210>  5225
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5225
agauggcau                                                              9

<210>  5226
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5226
agauggca                                                               8

<210>  5227
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5227
ctccaacauc aaggaagaug gcauuucuag                                       30

<210>  5228
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5228
ctccaacauc aaggaagaug gcauuucua                                        29

<210>  5229
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5229
ctccaacauc aaggaagaug gcauuucu                                         28

<210>  5230
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5230
ctccaacauc aaggaagaug gcauuuc                                          27

<210>  5231
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5231
ctccaacauc aaggaagaug gcauuu                                           26

<210>  5232
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5232
ctccaacauc aaggaagaug gcauu                                            25

<210>  5233
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5233
ctccaacauc aaggaagaug gcau                                             24

<210>  5234
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5234
ctccaacauc aaggaagaug gca                                              23

<210>  5235
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5235
ctccaacauc aaggaagaug gc                                               22

<210>  5236
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5236
ctccaacauc aaggaagaug g                                                21

<210>  5237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5237
ctccaacauc aaggaagaug                                                  20

<210>  5238
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5238
ctccaacauc aaggaagau                                                   19

<210>  5239
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5239
ctccaacauc aaggaaga                                                    18

<210>  5240
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5240
ctccaacauc aaggaag                                                     17

<210>  5241
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5241
tccaacauca aggaagaugg cauuucuag                                        29

<210>  5242
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5242
tccaacauca aggaagaugg cauuucua                                         28

<210>  5243
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5243
tccaacauca aggaagaugg cauuucu                                          27

<210>  5244
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5244
tccaacauca aggaagaugg cauuuc                                           26

<210>  5245
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5245
tccaacauca aggaagaugg cauuu                                            25

<210>  5246
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5246
tccaacauca aggaagaugg cauu                                             24

<210>  5247
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5247
tccaacauca aggaagaugg cau                                              23

<210>  5248
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5248
tccaacauca aggaagaugg ca                                               22

<210>  5249
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5249
tccaacauca aggaagaugg c                                                21

<210>  5250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5250
tccaacauca aggaagaugg                                                  20

<210>  5251
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5251
tccaacauca aggaagaug                                                   19

<210>  5252
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5252
tccaacauca aggaagau                                                    18

<210>  5253
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5253
tccaacauca aggaaga                                                     17

<210>  5254
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5254
tccaacauca aggaag                                                      16

<210>  5255
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5255
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  5256
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5256
ccaacaucaa ggaagauggc auuucua                                          27

<210>  5257
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5257
ccaacaucaa ggaagauggc auuucu                                           26

<210>  5258
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5258
ccaacaucaa ggaagauggc auuuc                                            25

<210>  5259
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5259
ccaacaucaa ggaagauggc auuu                                             24

<210>  5260
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5260
ccaacaucaa ggaagauggc auu                                              23

<210>  5261
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5261
ccaacaucaa ggaagauggc au                                               22

<210>  5262
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5262
ccaacaucaa ggaagauggc a                                                21

<210>  5263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5263
ccaacaucaa ggaagauggc                                                  20

<210>  5264
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5264
ccaacaucaa ggaagaugg                                                   19

<210>  5265
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5265
ccaacaucaa ggaagaug                                                    18

<210>  5266
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5266
ccaacaucaa ggaagau                                                     17

<210>  5267
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5267
ccaacaucaa ggaaga                                                      16

<210>  5268
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5268
ccaacaucaa ggaag                                                       15

<210>  5269
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5269
caacaucaag gaagauggca uuucuag                                          27

<210>  5270
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5270
caacaucaag gaagauggca uuucua                                           26

<210>  5271
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5271
caacaucaag gaagauggca uuucu                                            25

<210>  5272
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5272
caacaucaag gaagauggca uuuc                                             24

<210>  5273
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5273
caacaucaag gaagauggca uuu                                              23

<210>  5274
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5274
caacaucaag gaagauggca uu                                               22

<210>  5275
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5275
caacaucaag gaagauggca u                                                21

<210>  5276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5276
caacaucaag gaagauggca                                                  20

<210>  5277
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5277
caacaucaag gaagauggc                                                   19

<210>  5278
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5278
caacaucaag gaagaugg                                                    18

<210>  5279
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5279
caacaucaag gaagaug                                                     17

<210>  5280
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5280
caacaucaag gaagau                                                      16

<210>  5281
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5281
caacaucaag gaaga                                                       15

<210>  5282
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5282
caacaucaag gaag                                                        14

<210>  5283
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  5283
aacaucaagg aagauggcau uucuag                                           26

<210>  5284
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  5284
aacaucaagg aagauggcau uucua                                            25

<210>  5285
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  5285
aacaucaagg aagauggcau uucu                                             24

<210>  5286
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  5286
aacaucaagg aagauggcau uuc                                              23

<210>  5287
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  5287
aacaucaagg aagauggcau uu                                               22

<210>  5288
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  5288
aacaucaagg aagauggcau u                                                21

<210>  5289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  5289
aacaucaagg aagauggcau                                                  20

<210>  5290
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  5290
aacaucaagg aagauggca                                                   19

<210>  5291
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  5291
aacaucaagg aagauggc                                                    18

<210>  5292
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5292
aacaucaagg aagaugg                                                     17

<210>  5293
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5293
aacaucaagg aagaug                                                      16

<210>  5294
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5294
aacaucaagg aagau                                                       15

<210>  5295
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5295
aacaucaagg aaga                                                        14

<210>  5296
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5296
aacaucaagg aag                                                         13

<210>  5297
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  5297
acaucaagga agauggcauu ucuag                                            25

<210>  5298
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  5298
acaucaagga agauggcauu ucua                                             24

<210>  5299
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  5299
acaucaagga agauggcauu ucu                                              23

<210>  5300
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  5300
acaucaagga agauggcauu uc                                               22

<210>  5301
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5301
acaucaagga agauggcauu u                                                21

<210>  5302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5302
acaucaagga agauggcauu                                                  20

<210>  5303
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5303
acaucaagga agauggcau                                                   19

<210>  5304
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5304
acaucaagga agauggca                                                    18

<210>  5305
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5305
acaucaagga agauggc                                                     17

<210>  5306
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5306
acaucaagga agaugg                                                      16

<210>  5307
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5307
acaucaagga agaug                                                       15

<210>  5308
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5308
acaucaagga agau                                                        14

<210>  5309
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5309
acaucaagga aga                                                         13

<210>  5310
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5310
acaucaagga ag                                                          12

<210>  5311
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5311
caucaaggaa gauggcauuu cuag                                             24

<210>  5312
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5312
caucaaggaa gauggcauuu cua                                              23

<210>  5313
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5313
caucaaggaa gauggcauuu cu                                               22

<210>  5314
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5314
caucaaggaa gauggcauuu c                                                21

<210>  5315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5315
caucaaggaa gauggcauuu                                                  20

<210>  5316
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5316
caucaaggaa gauggcauu                                                   19

<210>  5317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5317
caucaaggaa gauggcau                                                    18

<210>  5318
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5318
caucaaggaa gauggca                                                     17

<210>  5319
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5319
caucaaggaa gauggc                                                      16

<210>  5320
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5320
caucaaggaa gaugg                                                       15

<210>  5321
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5321
caucaaggaa gaug                                                        14

<210>  5322
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5322
caucaaggaa gau                                                         13

<210>  5323
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5323
caucaaggaa ga                                                          12

<210>  5324
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  5324
caucaaggaa g                                                           11

<210>  5325
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5325
atcaaggaag auggcauuuc uag                                              23

<210>  5326
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5326
atcaaggaag auggcauuuc ua                                               22

<210>  5327
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5327
atcaaggaag auggcauuuc u                                                21

<210>  5328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5328
atcaaggaag auggcauuuc                                                  20

<210>  5329
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5329
atcaaggaag auggcauuu                                                   19

<210>  5330
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5330
atcaaggaag auggcauu                                                    18

<210>  5331
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5331
atcaaggaag auggcau                                                     17

<210>  5332
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5332
atcaaggaag auggca                                                      16

<210>  5333
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5333
atcaaggaag auggc                                                       15

<210>  5334
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5334
atcaaggaag augg                                                        14

<210>  5335
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5335
atcaaggaag aug                                                         13

<210>  5336
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5336
atcaaggaag au                                                          12

<210>  5337
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5337
atcaaggaag a                                                           11

<210>  5338
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5338
atcaaggaag                                                             10

<210>  5339
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5339
gguaaguucu guccaagc                                                    18

<210>  5340
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5340
guaaguucug uccaagcc                                                    18

<210>  5341
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5341
agucgguaag uucugucc                                                    18

<210>  5342
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5342
cuguccaagc ccgguuga                                                    18

<210>  5343
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5343
uaaguucugu ccaag                                                       15

<210>  5344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5344
uucuguccaa gcccgguuga                                                  20

<210>  5345
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5345
uucuguccaa gcccggutg                                                   19

<210>  5346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5346
uucuguccaa gcccggtt                                                    18

<210>  5347
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5347
uucuguccaa gcccggt                                                     17

<210>  5348
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5348
uucuguccaa gcccgg                                                      16

<210>  5349
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5349
uucuguccaa gcccg                                                       15

<210>  5350
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5350
uucuguccaa gccc                                                        14

<210>  5351
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5351
uucuguccaa gcc                                                         13

<210>  5352
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5352
uucuguccaa gc                                                          12

<210>  5353
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5353
uucuguccaa g                                                           11

<210>  5354
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5354
uucuguccaa                                                             10

<210>  5355
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5355
uucugucca                                                              9

<210>  5356
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5356
uucugucc                                                               8

<210>  5357
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5357
ucuguccaag cccgguuga                                                   19

<210>  5358
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5358
ucuguccaag cccggutg                                                    18

<210>  5359
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5359
ucuguccaag cccggtt                                                     17

<210>  5360
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5360
ucuguccaag cccggt                                                      16

<210>  5361
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5361
ucuguccaag cccgg                                                       15

<210>  5362
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5362
ucuguccaag cccg                                                        14

<210>  5363
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5363
ucuguccaag ccc                                                         13

<210>  5364
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5364
ucuguccaag cc                                                          12

<210>  5365
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5365
ucuguccaag c                                                           11

<210>  5366
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5366
ucuguccaag                                                             10

<210>  5367
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5367
ucuguccaa                                                              9

<210>  5368
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5368
ucugucca                                                               8

<210>  5369
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5369
cuguccaagc ccggutg                                                     17

<210>  5370
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5370
cuguccaagc ccggtt                                                      16

<210>  5371
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5371
cuguccaagc ccggt                                                       15

<210>  5372
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5372
cuguccaagc ccgg                                                        14

<210>  5373
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5373
cuguccaagc ccg                                                         13

<210>  5374
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5374
cuguccaagc cc                                                          12

<210>  5375
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5375
cuguccaagc c                                                           11

<210>  5376
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5376
cuguccaagc                                                             10

<210>  5377
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5377
cuguccaag                                                              9

<210>  5378
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5378
cuguccaa                                                               8

<210>  5379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5379
guucugucca agcccggutg                                                  20

<210>  5380
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5380
guucugucca agcccggtt                                                   19

<210>  5381
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5381
guucugucca agcccggt                                                    18

<210>  5382
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5382
guucugucca agcccgg                                                     17

<210>  5383
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5383
guucugucca agcccg                                                      16

<210>  5384
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5384
guucugucca agccc                                                       15

<210>  5385
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5385
guucugucca agcc                                                        14

<210>  5386
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5386
guucugucca agc                                                         13

<210>  5387
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5387
guucugucca ag                                                          12

<210>  5388
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5388
guucugucca a                                                           11

<210>  5389
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5389
guucugucca                                                             10

<210>  5390
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5390
guucugucc                                                              9

<210>  5391
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5391
guucugtc                                                               8

<210>  5392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5392
aguucugucc aagcccggtt                                                  20

<210>  5393
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5393
aguucugucc aagcccggt                                                   19

<210>  5394
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5394
aguucugucc aagcccgg                                                    18

<210>  5395
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5395
aguucugucc aagcccg                                                     17

<210>  5396
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5396
aguucugucc aagccc                                                      16

<210>  5397
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5397
aguucugucc aagcc                                                       15

<210>  5398
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5398
aguucugucc aagc                                                        14

<210>  5399
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5399
aguucugucc aag                                                         13

<210>  5400
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5400
aguucugucc aa                                                          12

<210>  5401
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5401
aguucugucc a                                                           11

<210>  5402
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5402
aguucugucc                                                             10

<210>  5403
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5403
aguucugtc                                                              9

<210>  5404
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5404
aguucugt                                                               8

<210>  5405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5405
aaguucuguc caagcccggt                                                  20

<210>  5406
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5406
aaguucuguc caagcccgg                                                   19

<210>  5407
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5407
aaguucuguc caagcccg                                                    18

<210>  5408
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5408
aaguucuguc caagccc                                                     17

<210>  5409
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5409
aaguucuguc caagcc                                                      16

<210>  5410
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5410
aaguucuguc caagc                                                       15

<210>  5411
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5411
aaguucuguc caag                                                        14

<210>  5412
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5412
aaguucuguc caa                                                         13

<210>  5413
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5413
aaguucuguc ca                                                          12

<210>  5414
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5414
aaguucuguc c                                                           11

<210>  5415
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5415
aaguucugtc                                                             10

<210>  5416
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5416
aaguucugt                                                              9

<210>  5417
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5417
aaguuctg                                                               8

<210>  5418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5418
uaaguucugu ccaagcccgg                                                  20

<210>  5419
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5419
uaaguucugu ccaagcccg                                                   19

<210>  5420
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5420
uaaguucugu ccaagccc                                                    18

<210>  5421
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5421
uaaguucugu ccaagcc                                                     17

<210>  5422
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5422
uaaguucugu ccaagc                                                      16

<210>  5423
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5423
uaaguucugu ccaa                                                        14

<210>  5424
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5424
uaaguucugu cca                                                         13

<210>  5425
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5425
uaaguucugu cc                                                          12

<210>  5426
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5426
uaaguucugt c                                                           11

<210>  5427
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5427
uaaguucugt                                                             10

<210>  5428
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5428
uaaguuctg                                                              9

<210>  5429
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5429
uaaguuct                                                               8

<210>  5430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5430
guaaguucug uccaagcccg                                                  20

<210>  5431
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5431
guaaguucug uccaagccc                                                   19

<210>  5432
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5432
guaaguucug uccaagc                                                     17

<210>  5433
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5433
guaaguucug uccaag                                                      16

<210>  5434
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5434
guaaguucug uccaa                                                       15

<210>  5435
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5435
guaaguucug ucca                                                        14

<210>  5436
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5436
guaaguucug ucc                                                         13

<210>  5437
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5437
guaaguucug tc                                                          12

<210>  5438
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5438
guaaguucug t                                                           11

<210>  5439
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5439
guaaguuctg                                                             10

<210>  5440
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5440
guaaguuct                                                              9

<210>  5441
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5441
guaagutc                                                               8

<210>  5442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5442
gguaaguucu guccaagccc                                                  20

<210>  5443
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5443
gguaaguucu guccaagcc                                                   19

<210>  5444
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5444
gguaaguucu guccaag                                                     17

<210>  5445
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5445
gguaaguucu guccaa                                                      16

<210>  5446
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5446
gguaaguucu gucca                                                       15

<210>  5447
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5447
gguaaguucu gucc                                                        14

<210>  5448
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5448
gguaaguucu gtc                                                         13

<210>  5449
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5449
gguaaguucu gt                                                          12

<210>  5450
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5450
gguaaguuct g                                                           11

<210>  5451
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5451
gguaaguuct                                                             10

<210>  5452
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5452
gguaagutc                                                              9

<210>  5453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5453
cgguaaguuc uguccaagcc                                                  20

<210>  5454
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5454
cgguaaguuc uguccaagc                                                   19

<210>  5455
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5455
cgguaaguuc uguccaag                                                    18

<210>  5456
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5456
cgguaaguuc uguccaa                                                     17

<210>  5457
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5457
cgguaaguuc ugucca                                                      16

<210>  5458
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5458
cgguaaguuc ugucc                                                       15

<210>  5459
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5459
cgguaaguuc ugtc                                                        14

<210>  5460
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5460
cgguaaguuc ugt                                                         13

<210>  5461
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5461
cgguaaguuc tg                                                          12

<210>  5462
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5462
cgguaaguuc t                                                           11

<210>  5463
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5463
cgguaagutc                                                             10

<210>  5464
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5464
cgguaagtt                                                              9

<210>  5465
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5465
cgguaagt                                                               8

<210>  5466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5466
ucgguaaguu cuguccaagc                                                  20

<210>  5467
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5467
ucgguaaguu cuguccaag                                                   19

<210>  5468
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5468
ucgguaaguu cuguccaa                                                    18

<210>  5469
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5469
ucgguaaguu cugucca                                                     17

<210>  5470
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5470
ucgguaaguu cugucc                                                      16

<210>  5471
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5471
ucgguaaguu cugtc                                                       15

<210>  5472
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5472
ucgguaaguu cugt                                                        14

<210>  5473
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5473
ucgguaaguu ctg                                                         13

<210>  5474
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5474
ucgguaaguu ct                                                          12

<210>  5475
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5475
ucgguaagut c                                                           11

<210>  5476
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5476
ucgguaagtt                                                             10

<210>  5477
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5477
ucgguaagt                                                              9

<210>  5478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5478
gucgguaagu ucuguccaag                                                  20

<210>  5479
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5479
gucgguaagu ucuguccaa                                                   19

<210>  5480
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5480
gucgguaagu ucugucca                                                    18

<210>  5481
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5481
gucgguaagu ucugucc                                                     17

<210>  5482
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5482
gucgguaagu ucugtc                                                      16

<210>  5483
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5483
gucgguaagu ucugt                                                       15

<210>  5484
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5484
gucgguaagu uctg                                                        14

<210>  5485
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5485
gucgguaagu uct                                                         13

<210>  5486
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5486
gucgguaagu tc                                                          12

<210>  5487
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5487
gucgguaagt t                                                           11

<210>  5488
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5488
gucgguaagt                                                             10

<210>  5489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5489
agucgguaag uucuguccaa                                                  20

<210>  5490
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5490
agucgguaag uucugucca                                                   19

<210>  5491
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5491
agucgguaag uucugtc                                                     17

<210>  5492
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5492
agucgguaag uucugt                                                      16

<210>  5493
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5493
agucgguaag uuctg                                                       15

<210>  5494
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5494
agucgguaag uuct                                                        14

<210>  5495
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5495
agucgguaag utc                                                         13

<210>  5496
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5496
agucgguaag tt                                                          12

<210>  5497
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5497
agucgguaag t                                                           11

<210>  5498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5498
cagucgguaa guucugucca                                                  20

<210>  5499
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5499
cagucgguaa guucugucc                                                   19

<210>  5500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5500
cagucgguaa guucugtc                                                    18

<210>  5501
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5501
cagucgguaa guucugt                                                     17

<210>  5502
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5502
cagucgguaa guuctg                                                      16

<210>  5503
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5503
cagucgguaa guuct                                                       15

<210>  5504
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5504
cagucgguaa gutc                                                        14

<210>  5505
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5505
cagucgguaa gtt                                                         13

<210>  5506
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5506
cagucgguaa gt                                                          12

<210>  5507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5507
ccagucggua aguucugucc                                                  20

<210>  5508
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5508
ccagucggua aguucugtc                                                   19

<210>  5509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5509
ccagucggua aguucugt                                                    18

<210>  5510
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5510
ccagucggua aguuctg                                                     17

<210>  5511
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5511
ccagucggua aguuct                                                      16

<210>  5512
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5512
ccagucggua agutc                                                       15

<210>  5513
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5513
ccagucggua agtt                                                        14

<210>  5514
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5514
ccagucggua agt                                                         13

<210>  5515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5515
gccagucggu aaguucugtc                                                  20

<210>  5516
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5516
gccagucggu aaguucugt                                                   19

<210>  5517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5517
gccagucggu aaguuctg                                                    18

<210>  5518
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5518
gccagucggu aaguuct                                                     17

<210>  5519
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5519
gccagucggu aagutc                                                      16

<210>  5520
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5520
gccagucggu aagtt                                                       15

<210>  5521
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5521
gccagucggu aagt                                                        14

<210>  5522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5522
ucaaggaaga uggcauuuct                                                  20

<210>  5523
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5523
ucaaggaaga uggcauuucu ag                                               22

<210>  5524
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5524
ucaaggaaga uggcat                                                      16

<210>  5525
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5525
gaagauggca uuuct                                                       15

<210>  5526
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5526
ucaaggaaga uggcauuuct a                                                21

<210>  5527
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5527
ucaaggaaga uggcauutc                                                   19

<210>  5528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5528
ucaaggaaga uggcautt                                                    18

<210>  5529
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5529
ucaaggaaga uggcatt                                                     17

<210>  5530
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5530
ucaaggaaga uggca                                                       15

<210>  5531
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5531
ucaaggaaga uggc                                                        14

<210>  5532
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5532
ucaaggaaga ugg                                                         13

<210>  5533
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5533
ucaaggaaga tg                                                          12

<210>  5534
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5534
ucaaggaaga t                                                           11

<210>  5535
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5535
ucaaggaaga                                                             10

<210>  5536
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5536
ucaaggaag                                                              9

<210>  5537
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5537
caaggaagau ggcauuucua g                                                21

<210>  5538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5538
caaggaagau ggcauuucta                                                  20

<210>  5539
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5539
caaggaagau ggcauuuct                                                   19

<210>  5540
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5540
caaggaagau ggcauutc                                                    18

<210>  5541
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5541
caaggaagau ggcautt                                                     17

<210>  5542
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5542
caaggaagau ggcatt                                                      16

<210>  5543
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5543
caaggaagau ggcat                                                       15

<210>  5544
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5544
caaggaagau ggca                                                        14

<210>  5545
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5545
caaggaagau ggc                                                         13

<210>  5546
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5546
caaggaagau gg                                                          12

<210>  5547
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5547
caaggaagat g                                                           11

<210>  5548
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5548
caaggaagat                                                             10

<210>  5549
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5549
caaggaaga                                                              9

<210>  5550
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5550
caaggaag                                                               8

<210>  5551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5551
aaggaagaug gcauuucuag                                                  20

<210>  5552
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5552
aaggaagaug gcauuucta                                                   19

<210>  5553
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5553
aaggaagaug gcauuuct                                                    18

<210>  5554
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5554
aaggaagaug gcauutc                                                     17

<210>  5555
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5555
aaggaagaug gcautt                                                      16

<210>  5556
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5556
aaggaagaug gcatt                                                       15

<210>  5557
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5557
aaggaagaug gcat                                                        14

<210>  5558
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5558
aaggaagaug gca                                                         13

<210>  5559
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5559
aaggaagaug gc                                                          12

<210>  5560
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5560
aggaagaugg cauuucuag                                                   19

<210>  5561
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5561
aggaagaugg cauuucta                                                    18

<210>  5562
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5562
aggaagaugg cauuuct                                                     17

<210>  5563
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5563
aggaagaugg cauutc                                                      16

<210>  5564
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5564
aggaagaugg cautt                                                       15

<210>  5565
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5565
aggaagaugg catt                                                        14

<210>  5566
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5566
aggaagaugg cat                                                         13

<210>  5567
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5567
aggaagaugg ca                                                          12

<210>  5568
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5568
ggaagauggc auuucuag                                                    18

<210>  5569
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5569
ggaagauggc auuucta                                                     17

<210>  5570
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5570
ggaagauggc auuuct                                                      16

<210>  5571
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5571
ggaagauggc auutc                                                       15

<210>  5572
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5572
ggaagauggc autt                                                        14

<210>  5573
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5573
ggaagauggc att                                                         13

<210>  5574
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5574
ggaagauggc at                                                          12

<210>  5575
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5575
ggaagauggc a                                                           11

<210>  5576
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5576
ggaagauggc                                                             10

<210>  5577
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5577
gaagauggca uuucuag                                                     17

<210>  5578
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5578
gaagauggca uuucta                                                      16

<210>  5579
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5579
gaagauggca uutc                                                        14

<210>  5580
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5580
gaagauggca utt                                                         13

<210>  5581
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5581
gaagauggca tt                                                          12

<210>  5582
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5582
gaagauggca t                                                           11

<210>  5583
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5583
gaagauggca                                                             10

<210>  5584
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5584
gaagauggc                                                              9

<210>  5585
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5585
aagauggcau uucuag                                                      16

<210>  5586
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5586
aagauggcau uucta                                                       15

<210>  5587
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5587
aagauggcau uuct                                                        14

<210>  5588
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5588
aagauggcau utc                                                         13

<210>  5589
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5589
aagauggcau tt                                                          12

<210>  5590
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5590
aagauggcat t                                                           11

<210>  5591
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5591
aagauggcat                                                             10

<210>  5592
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5592
aagauggca                                                              9

<210>  5593
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5593
aagauggc                                                               8

<210>  5594
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5594
agauggcauu ucuag                                                       15

<210>  5595
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5595
agauggcauu ucta                                                        14

<210>  5596
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5596
agauggcauu uct                                                         13

<210>  5597
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5597
agauggcauu tc                                                          12

<210>  5598
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5598
agauggcaut t                                                           11

<210>  5599
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5599
agauggcatt                                                             10

<210>  5600
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5600
agauggcat                                                              9

<210>  5601
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5601
agauggca                                                               8

<210>  5602
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  5602
cuccaacauc aaggaagaug gcauuucuag                                       30

<210>  5603
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  5603
cuccaacauc aaggaagaug gcauuucta                                        29

<210>  5604
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  5604
cuccaacauc aaggaagaug gcauuuct                                         28

<210>  5605
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  5605
cuccaacauc aaggaagaug gcauutc                                          27

<210>  5606
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  5606
cuccaacauc aaggaagaug gcautt                                           26

<210>  5607
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5607
cuccaacauc aaggaagaug gcatt                                            25

<210>  5608
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5608
cuccaacauc aaggaagaug gcat                                             24

<210>  5609
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5609
cuccaacauc aaggaagaug gca                                              23

<210>  5610
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5610
cuccaacauc aaggaagaug gc                                               22

<210>  5611
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5611
cuccaacauc aaggaagaug g                                                21

<210>  5612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5612
cuccaacauc aaggaagatg                                                  20

<210>  5613
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5613
cuccaacauc aaggaagat                                                   19

<210>  5614
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5614
cuccaacauc aaggaaga                                                    18

<210>  5615
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5615
cuccaacauc aaggaag                                                     17

<210>  5616
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  5616
uccaacauca aggaagaugg cauuucuag                                        29

<210>  5617
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  5617
uccaacauca aggaagaugg cauuucta                                         28

<210>  5618
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  5618
uccaacauca aggaagaugg cauuuct                                          27

<210>  5619
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  5619
uccaacauca aggaagaugg cauutc                                           26

<210>  5620
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5620
uccaacauca aggaagaugg cautt                                            25

<210>  5621
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5621
uccaacauca aggaagaugg catt                                             24

<210>  5622
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5622
uccaacauca aggaagaugg cat                                              23

<210>  5623
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5623
uccaacauca aggaagaugg ca                                               22

<210>  5624
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5624
uccaacauca aggaagaugg c                                                21

<210>  5625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5625
uccaacauca aggaagaugg                                                  20

<210>  5626
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5626
uccaacauca aggaagatg                                                   19

<210>  5627
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5627
uccaacauca aggaagat                                                    18

<210>  5628
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5628
uccaacauca aggaaga                                                     17

<210>  5629
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5629
uccaacauca aggaag                                                      16

<210>  5630
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  5630
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  5631
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  5631
ccaacaucaa ggaagauggc auuucta                                          27

<210>  5632
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  5632
ccaacaucaa ggaagauggc auuuct                                           26

<210>  5633
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5633
ccaacaucaa ggaagauggc auutc                                            25

<210>  5634
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5634
ccaacaucaa ggaagauggc autt                                             24

<210>  5635
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5635
ccaacaucaa ggaagauggc att                                              23

<210>  5636
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5636
ccaacaucaa ggaagauggc at                                               22

<210>  5637
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5637
ccaacaucaa ggaagauggc a                                                21

<210>  5638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5638
ccaacaucaa ggaagauggc                                                  20

<210>  5639
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5639
ccaacaucaa ggaagaugg                                                   19

<210>  5640
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5640
ccaacaucaa ggaagatg                                                    18

<210>  5641
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5641
ccaacaucaa ggaagat                                                     17

<210>  5642
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5642
ccaacaucaa ggaaga                                                      16

<210>  5643
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5643
ccaacaucaa ggaag                                                       15

<210>  5644
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  5644
caacaucaag gaagauggca uuucuag                                          27

<210>  5645
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  5645
caacaucaag gaagauggca uuucta                                           26

<210>  5646
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5646
caacaucaag gaagauggca uuuct                                            25

<210>  5647
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5647
caacaucaag gaagauggca uutc                                             24

<210>  5648
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5648
caacaucaag gaagauggca utt                                              23

<210>  5649
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5649
caacaucaag gaagauggca tt                                               22

<210>  5650
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5650
caacaucaag gaagauggca t                                                21

<210>  5651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5651
caacaucaag gaagauggca                                                  20

<210>  5652
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5652
caacaucaag gaagauggc                                                   19

<210>  5653
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5653
caacaucaag gaagaugg                                                    18

<210>  5654
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5654
caacaucaag gaagatg                                                     17

<210>  5655
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5655
caacaucaag gaagat                                                      16

<210>  5656
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5656
caacaucaag gaaga                                                       15

<210>  5657
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5657
caacaucaag gaag                                                        14

<210>  5658
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  5658
aacaucaagg aagauggcau uucuag                                           26

<210>  5659
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5659
aacaucaagg aagauggcau uucta                                            25

<210>  5660
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5660
aacaucaagg aagauggcau uuct                                             24

<210>  5661
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5661
aacaucaagg aagauggcau utc                                              23

<210>  5662
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5662
aacaucaagg aagauggcau tt                                               22

<210>  5663
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5663
aacaucaagg aagauggcat t                                                21

<210>  5664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5664
aacaucaagg aagauggcat                                                  20

<210>  5665
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5665
aacaucaagg aagauggca                                                   19

<210>  5666
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5666
aacaucaagg aagauggc                                                    18

<210>  5667
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5667
aacaucaagg aagaugg                                                     17

<210>  5668
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5668
aacaucaagg aagatg                                                      16

<210>  5669
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5669
aacaucaagg aagat                                                       15

<210>  5670
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5670
aacaucaagg aaga                                                        14

<210>  5671
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5671
aacaucaagg aag                                                         13

<210>  5672
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5672
acaucaagga agauggcauu ucuag                                            25

<210>  5673
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5673
acaucaagga agauggcauu ucta                                             24

<210>  5674
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5674
acaucaagga agauggcauu uct                                              23

<210>  5675
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5675
acaucaagga agauggcauu tc                                               22

<210>  5676
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5676
acaucaagga agauggcaut t                                                21

<210>  5677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5677
acaucaagga agauggcatt                                                  20

<210>  5678
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5678
acaucaagga agauggcat                                                   19

<210>  5679
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5679
acaucaagga agauggca                                                    18

<210>  5680
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5680
acaucaagga agauggc                                                     17

<210>  5681
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5681
acaucaagga agaugg                                                      16

<210>  5682
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5682
acaucaagga agatg                                                       15

<210>  5683
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5683
acaucaagga agat                                                        14

<210>  5684
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5684
acaucaagga aga                                                         13

<210>  5685
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5685
acaucaagga ag                                                          12

<210>  5686
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5686
caucaaggaa gauggcauuu cuag                                             24

<210>  5687
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5687
caucaaggaa gauggcauuu cta                                              23

<210>  5688
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5688
caucaaggaa gauggcauuu ct                                               22

<210>  5689
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5689
caucaaggaa gauggcauut c                                                21

<210>  5690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5690
caucaaggaa gauggcautt                                                  20

<210>  5691
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5691
caucaaggaa gauggcatt                                                   19

<210>  5692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5692
caucaaggaa gauggcat                                                    18

<210>  5693
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5693
caucaaggaa gauggca                                                     17

<210>  5694
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5694
caucaaggaa gauggc                                                      16

<210>  5695
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5695
caucaaggaa gaugg                                                       15

<210>  5696
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5696
caucaaggaa gatg                                                        14

<210>  5697
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5697
caucaaggaa gat                                                         13

<210>  5698
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5698
caucaaggaa ga                                                          12

<210>  5699
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5699
caucaaggaa g                                                           11

<210>  5700
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5700
aucaaggaag auggcauuuc uag                                              23

<210>  5701
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5701
aucaaggaag auggcauuuc ta                                               22

<210>  5702
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5702
aucaaggaag auggcauuuc t                                                21

<210>  5703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5703
aucaaggaag auggcauutc                                                  20

<210>  5704
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5704
aucaaggaag auggcautt                                                   19

<210>  5705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5705
aucaaggaag auggcatt                                                    18

<210>  5706
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5706
aucaaggaag auggcat                                                     17

<210>  5707
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5707
aucaaggaag auggca                                                      16

<210>  5708
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5708
aucaaggaag auggc                                                       15

<210>  5709
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5709
aucaaggaag augg                                                        14

<210>  5710
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5710
aucaaggaag atg                                                         13

<210>  5711
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5711
aucaaggaag at                                                          12

<210>  5712
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5712
aucaaggaag a                                                           11

<210>  5713
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5713
aucaaggaag                                                             10

<210>  5714
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  5714
gguaaguucu guccaagc                                                    18

<210>  5715
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  5715
gtaaguucug uccaagcc                                                    18

<210>  5716
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  5716
agucgguaag uucugucc                                                    18

<210>  5717
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5717
ctguccaagc ccgguuga                                                    18

<210>  5718
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5718
taaguucugu ccaag                                                       15

<210>  5719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5719
ttcuguccaa gcccgguuga                                                  20

<210>  5720
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5720
ttcuguccaa gcccggutg                                                   19

<210>  5721
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5721
ttcuguccaa gcccggtt                                                    18

<210>  5722
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5722
ttcuguccaa gcccggt                                                     17

<210>  5723
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5723
ttcuguccaa gcccgg                                                      16

<210>  5724
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5724
ttcuguccaa gcccg                                                       15

<210>  5725
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  5725
ttcuguccaa gccc                                                        14

<210>  5726
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5726
ttcuguccaa gcc                                                         13

<210>  5727
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5727
ttcuguccaa gc                                                          12

<210>  5728
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  5728
ttcuguccaa g                                                           11

<210>  5729
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  5729
ttcuguccaa                                                             10

<210>  5730
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  5730
ttcugucca                                                              9

<210>  5731
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  5731
ttcugucc                                                               8

<210>  5732
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5732
tcuguccaag cccgguuga                                                   19

<210>  5733
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5733
tcuguccaag cccggutg                                                    18

<210>  5734
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5734
tcuguccaag cccggtt                                                     17

<210>  5735
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5735
tcuguccaag cccggt                                                      16

<210>  5736
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5736
tcuguccaag cccgg                                                       15

<210>  5737
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5737
tcuguccaag cccg                                                        14

<210>  5738
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  5738
tcuguccaag ccc                                                         13

<210>  5739
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5739
tcuguccaag cc                                                          12

<210>  5740
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5740
tcuguccaag c                                                           11

<210>  5741
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  5741
tcuguccaag                                                             10

<210>  5742
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  5742
tcuguccaa                                                              9

<210>  5743
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  5743
tcugucca                                                               8

<210>  5744
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5744
ctguccaagc ccggutg                                                     17

<210>  5745
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5745
ctguccaagc ccggtt                                                      16

<210>  5746
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5746
ctguccaagc ccggt                                                       15

<210>  5747
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5747
ctguccaagc ccgg                                                        14

<210>  5748
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5748
ctguccaagc ccg                                                         13

<210>  5749
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5749
ctguccaagc cc                                                          12

<210>  5750
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5750
ctguccaagc c                                                           11

<210>  5751
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5751
ctguccaagc                                                             10

<210>  5752
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5752
ctguccaag                                                              9

<210>  5753
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5753
ctguccaa                                                               8

<210>  5754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5754
gtucugucca agcccggutg                                                  20

<210>  5755
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5755
gtucugucca agcccggtt                                                   19

<210>  5756
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5756
gtucugucca agcccggt                                                    18

<210>  5757
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5757
gtucugucca agcccgg                                                     17

<210>  5758
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5758
gtucugucca agcccg                                                      16

<210>  5759
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  5759
gtucugucca agccc                                                       15

<210>  5760
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5760
gtucugucca agcc                                                        14

<210>  5761
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5761
gtucugucca agc                                                         13

<210>  5762
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5762
gtucugucca ag                                                          12

<210>  5763
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5763
gtucugucca a                                                           11

<210>  5764
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5764
gtucugucca                                                             10

<210>  5765
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  5765
gtucugucc                                                              9

<210>  5766
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5766
gtucugtc                                                               8

<210>  5767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5767
aguucugucc aagcccggtt                                                  20

<210>  5768
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5768
aguucugucc aagcccggt                                                   19

<210>  5769
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5769
aguucugucc aagcccgg                                                    18

<210>  5770
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5770
aguucugucc aagcccg                                                     17

<210>  5771
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  5771
aguucugucc aagccc                                                      16

<210>  5772
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  5772
aguucugucc aagcc                                                       15

<210>  5773
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5773
aguucugucc aagc                                                        14

<210>  5774
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5774
aguucugucc aag                                                         13

<210>  5775
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5775
aguucugucc aa                                                          12

<210>  5776
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5776
aguucugucc a                                                           11

<210>  5777
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  5777
aguucugucc                                                             10

<210>  5778
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5778
aguucugtc                                                              9

<210>  5779
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  5779
aguucugt                                                               8

<210>  5780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5780
aaguucuguc caagcccggt                                                  20

<210>  5781
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5781
aaguucuguc caagcccgg                                                   19

<210>  5782
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5782
aaguucuguc caagcccg                                                    18

<210>  5783
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  5783
aaguucuguc caagccc                                                     17

<210>  5784
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5784
aaguucuguc caagcc                                                      16

<210>  5785
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5785
aaguucuguc caagc                                                       15

<210>  5786
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5786
aaguucuguc caag                                                        14

<210>  5787
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5787
aaguucuguc caa                                                         13

<210>  5788
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5788
aaguucuguc ca                                                          12

<210>  5789
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  5789
aaguucuguc c                                                           11

<210>  5790
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5790
aaguucugtc                                                             10

<210>  5791
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5791
aaguucugt                                                              9

<210>  5792
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  5792
aaguuctg                                                               8

<210>  5793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  5793
taaguucugu ccaagcccgg                                                  20

<210>  5794
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  5794
taaguucugu ccaagcccg                                                   19

<210>  5795
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  5795
taaguucugu ccaagccc                                                    18

<210>  5796
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5796
taaguucugu ccaagcc                                                     17

<210>  5797
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5797
taaguucugu ccaagc                                                      16

<210>  5798
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5798
taaguucugu ccaa                                                        14

<210>  5799
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5799
taaguucugu cca                                                         13

<210>  5800
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  5800
taaguucugu cc                                                          12

<210>  5801
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5801
taaguucugt c                                                           11

<210>  5802
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5802
taaguucugt                                                             10

<210>  5803
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5803
taaguuctg                                                              9

<210>  5804
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5804
taaguuct                                                               8

<210>  5805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  5805
gtaaguucug uccaagcccg                                                  20

<210>  5806
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  5806
gtaaguucug uccaagccc                                                   19

<210>  5807
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5807
gtaaguucug uccaagc                                                     17

<210>  5808
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5808
gtaaguucug uccaag                                                      16

<210>  5809
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5809
gtaaguucug uccaa                                                       15

<210>  5810
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5810
gtaaguucug ucca                                                        14

<210>  5811
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  5811
gtaaguucug ucc                                                         13

<210>  5812
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5812
gtaaguucug tc                                                          12

<210>  5813
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5813
gtaaguucug t                                                           11

<210>  5814
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5814
gtaaguuctg                                                             10

<210>  5815
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5815
gtaaguuct                                                              9

<210>  5816
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5816
gtaagutc                                                               8

<210>  5817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  5817
gguaaguucu guccaagccc                                                  20

<210>  5818
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  5818
gguaaguucu guccaagcc                                                   19

<210>  5819
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5819
gguaaguucu guccaag                                                     17

<210>  5820
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5820
gguaaguucu guccaa                                                      16

<210>  5821
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5821
gguaaguucu gucca                                                       15

<210>  5822
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  5822
gguaaguucu gucc                                                        14

<210>  5823
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5823
gguaaguucu gtc                                                         13

<210>  5824
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5824
gguaaguucu gt                                                          12

<210>  5825
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5825
gguaaguuct g                                                           11

<210>  5826
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5826
gguaaguuct                                                             10

<210>  5827
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5827
gguaagutc                                                              9

<210>  5828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5828
cgguaaguuc uguccaagcc                                                  20

<210>  5829
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5829
cgguaaguuc uguccaagc                                                   19

<210>  5830
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5830
cgguaaguuc uguccaag                                                    18

<210>  5831
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5831
cgguaaguuc uguccaa                                                     17

<210>  5832
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5832
cgguaaguuc ugucca                                                      16

<210>  5833
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5833
cgguaaguuc ugucc                                                       15

<210>  5834
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5834
cgguaaguuc ugtc                                                        14

<210>  5835
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5835
cgguaaguuc ugt                                                         13

<210>  5836
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5836
cgguaaguuc tg                                                          12

<210>  5837
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5837
cgguaaguuc t                                                           11

<210>  5838
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5838
cgguaagutc                                                             10

<210>  5839
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5839
cgguaagtt                                                              9

<210>  5840
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5840
cgguaagt                                                               8

<210>  5841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5841
tcgguaaguu cuguccaagc                                                  20

<210>  5842
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5842
tcgguaaguu cuguccaag                                                   19

<210>  5843
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5843
tcgguaaguu cuguccaa                                                    18

<210>  5844
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5844
tcgguaaguu cugucca                                                     17

<210>  5845
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  5845
tcgguaaguu cugucc                                                      16

<210>  5846
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5846
tcgguaaguu cugtc                                                       15

<210>  5847
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5847
tcgguaaguu cugt                                                        14

<210>  5848
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5848
tcgguaaguu ctg                                                         13

<210>  5849
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5849
tcgguaaguu ct                                                          12

<210>  5850
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5850
tcgguaagut c                                                           11

<210>  5851
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5851
tcgguaagtt                                                             10

<210>  5852
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5852
tcgguaagt                                                              9

<210>  5853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5853
gtcgguaagu ucuguccaag                                                  20

<210>  5854
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5854
gtcgguaagu ucuguccaa                                                   19

<210>  5855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5855
gtcgguaagu ucugucca                                                    18

<210>  5856
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  5856
gtcgguaagu ucugucc                                                     17

<210>  5857
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5857
gtcgguaagu ucugtc                                                      16

<210>  5858
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5858
gtcgguaagu ucugt                                                       15

<210>  5859
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5859
gtcgguaagu uctg                                                        14

<210>  5860
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5860
gtcgguaagu uct                                                         13

<210>  5861
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5861
gtcgguaagu tc                                                          12

<210>  5862
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5862
gtcgguaagt t                                                           11

<210>  5863
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  5863
gtcgguaagt                                                             10

<210>  5864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  5864
agucgguaag uucuguccaa                                                  20

<210>  5865
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  5865
agucgguaag uucugucca                                                   19

<210>  5866
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5866
agucgguaag uucugtc                                                     17

<210>  5867
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5867
agucgguaag uucugt                                                      16

<210>  5868
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5868
agucgguaag uuctg                                                       15

<210>  5869
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5869
agucgguaag uuct                                                        14

<210>  5870
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5870
agucgguaag utc                                                         13

<210>  5871
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  5871
agucgguaag tt                                                          12

<210>  5872
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  5872
agucgguaag t                                                           11

<210>  5873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5873
cagucgguaa guucugucca                                                  20

<210>  5874
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5874
cagucgguaa guucugucc                                                   19

<210>  5875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5875
cagucgguaa guucugtc                                                    18

<210>  5876
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5876
cagucgguaa guucugt                                                     17

<210>  5877
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5877
cagucgguaa guuctg                                                      16

<210>  5878
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5878
cagucgguaa guuct                                                       15

<210>  5879
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5879
cagucgguaa gutc                                                        14

<210>  5880
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5880
cagucgguaa gtt                                                         13

<210>  5881
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5881
cagucgguaa gt                                                          12

<210>  5882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5882
ccagucggua aguucugucc                                                  20

<210>  5883
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5883
ccagucggua aguucugtc                                                   19

<210>  5884
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5884
ccagucggua aguucugt                                                    18

<210>  5885
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5885
ccagucggua aguuctg                                                     17

<210>  5886
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5886
ccagucggua aguuct                                                      16

<210>  5887
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5887
ccagucggua agutc                                                       15

<210>  5888
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5888
ccagucggua agtt                                                        14

<210>  5889
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5889
ccagucggua agt                                                         13

<210>  5890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  5890
gccagucggu aaguucugtc                                                  20

<210>  5891
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5891
gccagucggu aaguucugt                                                   19

<210>  5892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5892
gccagucggu aaguuctg                                                    18

<210>  5893
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5893
gccagucggu aaguuct                                                     17

<210>  5894
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5894
gccagucggu aagutc                                                      16

<210>  5895
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5895
gccagucggu aagtt                                                       15

<210>  5896
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5896
gccagucggu aagt                                                        14

<210>  5897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5897
tcaaggaaga uggcauuuct                                                  20

<210>  5898
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5898
tcaaggaaga uggcauuucu ag                                               22

<210>  5899
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5899
tcaaggaaga uggcat                                                      16

<210>  5900
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5900
gaagauggca uuuct                                                       15

<210>  5901
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5901
tcaaggaaga uggcauuuct a                                                21

<210>  5902
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  5902
tcaaggaaga uggcauutc                                                   19

<210>  5903
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5903
tcaaggaaga uggcautt                                                    18

<210>  5904
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5904
tcaaggaaga uggcatt                                                     17

<210>  5905
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5905
tcaaggaaga uggca                                                       15

<210>  5906
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5906
tcaaggaaga uggc                                                        14

<210>  5907
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5907
tcaaggaaga ugg                                                         13

<210>  5908
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5908
tcaaggaaga tg                                                          12

<210>  5909
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5909
tcaaggaaga t                                                           11

<210>  5910
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5910
tcaaggaaga                                                             10

<210>  5911
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  5911
tcaaggaag                                                              9

<210>  5912
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5912
caaggaagau ggcauuucua g                                                21

<210>  5913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5913
caaggaagau ggcauuucta                                                  20

<210>  5914
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5914
caaggaagau ggcauuuct                                                   19

<210>  5915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5915
caaggaagau ggcauutc                                                    18

<210>  5916
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5916
caaggaagau ggcautt                                                     17

<210>  5917
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  5917
caaggaagau ggcatt                                                      16

<210>  5918
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  5918
caaggaagau ggcat                                                       15

<210>  5919
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  5919
caaggaagau ggca                                                        14

<210>  5920
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  5920
caaggaagau ggc                                                         13

<210>  5921
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  5921
caaggaagau gg                                                          12

<210>  5922
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  5922
caaggaagat g                                                           11

<210>  5923
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  5923
caaggaagat                                                             10

<210>  5924
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  5924
caaggaaga                                                              9

<210>  5925
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  5925
caaggaag                                                               8

<210>  5926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5926
aaggaagaug gcauuucuag                                                  20

<210>  5927
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5927
aaggaagaug gcauuucta                                                   19

<210>  5928
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5928
aaggaagaug gcauuuct                                                    18

<210>  5929
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  5929
aaggaagaug gcauutc                                                     17

<210>  5930
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5930
aaggaagaug gcautt                                                      16

<210>  5931
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5931
aaggaagaug gcatt                                                       15

<210>  5932
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5932
aaggaagaug gcat                                                        14

<210>  5933
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5933
aaggaagaug gca                                                         13

<210>  5934
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5934
aaggaagaug gc                                                          12

<210>  5935
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5935
aggaagaugg cauuucuag                                                   19

<210>  5936
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5936
aggaagaugg cauuucta                                                    18

<210>  5937
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5937
aggaagaugg cauuuct                                                     17

<210>  5938
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  5938
aggaagaugg cauutc                                                      16

<210>  5939
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5939
aggaagaugg cautt                                                       15

<210>  5940
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5940
aggaagaugg catt                                                        14

<210>  5941
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5941
aggaagaugg cat                                                         13

<210>  5942
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  5942
aggaagaugg ca                                                          12

<210>  5943
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5943
ggaagauggc auuucuag                                                    18

<210>  5944
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5944
ggaagauggc auuucta                                                     17

<210>  5945
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5945
ggaagauggc auuuct                                                      16

<210>  5946
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  5946
ggaagauggc auutc                                                       15

<210>  5947
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5947
ggaagauggc autt                                                        14

<210>  5948
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5948
ggaagauggc att                                                         13

<210>  5949
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5949
ggaagauggc at                                                          12

<210>  5950
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5950
ggaagauggc a                                                           11

<210>  5951
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  5951
ggaagauggc                                                             10

<210>  5952
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5952
gaagauggca uuucuag                                                     17

<210>  5953
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5953
gaagauggca uuucta                                                      16

<210>  5954
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  5954
gaagauggca uutc                                                        14

<210>  5955
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5955
gaagauggca utt                                                         13

<210>  5956
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5956
gaagauggca tt                                                          12

<210>  5957
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5957
gaagauggca t                                                           11

<210>  5958
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5958
gaagauggca                                                             10

<210>  5959
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  5959
gaagauggc                                                              9

<210>  5960
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5960
aagauggcau uucuag                                                      16

<210>  5961
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5961
aagauggcau uucta                                                       15

<210>  5962
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5962
aagauggcau uuct                                                        14

<210>  5963
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  5963
aagauggcau utc                                                         13

<210>  5964
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5964
aagauggcau tt                                                          12

<210>  5965
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5965
aagauggcat t                                                           11

<210>  5966
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5966
aagauggcat                                                             10

<210>  5967
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5967
aagauggca                                                              9

<210>  5968
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  5968
aagauggc                                                               8

<210>  5969
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5969
agauggcauu ucuag                                                       15

<210>  5970
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5970
agauggcauu ucta                                                        14

<210>  5971
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5971
agauggcauu uct                                                         13

<210>  5972
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  5972
agauggcauu tc                                                          12

<210>  5973
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5973
agauggcaut t                                                           11

<210>  5974
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5974
agauggcatt                                                             10

<210>  5975
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5975
agauggcat                                                              9

<210>  5976
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  5976
agauggca                                                               8

<210>  5977
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  5977
ctccaacauc aaggaagaug gcauuucuag                                       30

<210>  5978
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  5978
ctccaacauc aaggaagaug gcauuucta                                        29

<210>  5979
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  5979
ctccaacauc aaggaagaug gcauuuct                                         28

<210>  5980
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  5980
ctccaacauc aaggaagaug gcauutc                                          27

<210>  5981
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  5981
ctccaacauc aaggaagaug gcautt                                           26

<210>  5982
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  5982
ctccaacauc aaggaagaug gcatt                                            25

<210>  5983
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  5983
ctccaacauc aaggaagaug gcat                                             24

<210>  5984
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  5984
ctccaacauc aaggaagaug gca                                              23

<210>  5985
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  5985
ctccaacauc aaggaagaug gc                                               22

<210>  5986
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  5986
ctccaacauc aaggaagaug g                                                21

<210>  5987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  5987
ctccaacauc aaggaagatg                                                  20

<210>  5988
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  5988
ctccaacauc aaggaagat                                                   19

<210>  5989
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  5989
ctccaacauc aaggaaga                                                    18

<210>  5990
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  5990
ctccaacauc aaggaag                                                     17

<210>  5991
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5991
tccaacauca aggaagaugg cauuucuag                                        29

<210>  5992
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5992
tccaacauca aggaagaugg cauuucta                                         28

<210>  5993
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5993
tccaacauca aggaagaugg cauuuct                                          27

<210>  5994
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  5994
tccaacauca aggaagaugg cauutc                                           26

<210>  5995
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5995
tccaacauca aggaagaugg cautt                                            25

<210>  5996
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5996
tccaacauca aggaagaugg catt                                             24

<210>  5997
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5997
tccaacauca aggaagaugg cat                                              23

<210>  5998
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5998
tccaacauca aggaagaugg ca                                               22

<210>  5999
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  5999
tccaacauca aggaagaugg c                                                21

<210>  6000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  6000
tccaacauca aggaagaugg                                                  20

<210>  6001
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  6001
tccaacauca aggaagatg                                                   19

<210>  6002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  6002
tccaacauca aggaagat                                                    18

<210>  6003
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  6003
tccaacauca aggaaga                                                     17

<210>  6004
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  6004
tccaacauca aggaag                                                      16

<210>  6005
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  6005
ccaacaucaa ggaagauggc auuucuag                                         28

<210>  6006
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  6006
ccaacaucaa ggaagauggc auuucta                                          27

<210>  6007
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6007
ccaacaucaa ggaagauggc auuuct                                           26

<210>  6008
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6008
ccaacaucaa ggaagauggc auutc                                            25

<210>  6009
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6009
ccaacaucaa ggaagauggc autt                                             24

<210>  6010
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6010
ccaacaucaa ggaagauggc att                                              23

<210>  6011
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6011
ccaacaucaa ggaagauggc at                                               22

<210>  6012
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6012
ccaacaucaa ggaagauggc a                                                21

<210>  6013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6013
ccaacaucaa ggaagauggc                                                  20

<210>  6014
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6014
ccaacaucaa ggaagaugg                                                   19

<210>  6015
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6015
ccaacaucaa ggaagatg                                                    18

<210>  6016
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6016
ccaacaucaa ggaagat                                                     17

<210>  6017
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6017
ccaacaucaa ggaaga                                                      16

<210>  6018
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6018
ccaacaucaa ggaag                                                       15

<210>  6019
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  6019
caacaucaag gaagauggca uuucuag                                          27

<210>  6020
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6020
caacaucaag gaagauggca uuucta                                           26

<210>  6021
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6021
caacaucaag gaagauggca uuuct                                            25

<210>  6022
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6022
caacaucaag gaagauggca uutc                                             24

<210>  6023
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6023
caacaucaag gaagauggca utt                                              23

<210>  6024
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6024
caacaucaag gaagauggca tt                                               22

<210>  6025
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6025
caacaucaag gaagauggca t                                                21

<210>  6026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6026
caacaucaag gaagauggca                                                  20

<210>  6027
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6027
caacaucaag gaagauggc                                                   19

<210>  6028
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6028
caacaucaag gaagaugg                                                    18

<210>  6029
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6029
caacaucaag gaagatg                                                     17

<210>  6030
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6030
caacaucaag gaagat                                                      16

<210>  6031
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6031
caacaucaag gaaga                                                       15

<210>  6032
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6032
caacaucaag gaag                                                        14

<210>  6033
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  6033
aacaucaagg aagauggcau uucuag                                           26

<210>  6034
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  6034
aacaucaagg aagauggcau uucta                                            25

<210>  6035
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  6035
aacaucaagg aagauggcau uuct                                             24

<210>  6036
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  6036
aacaucaagg aagauggcau utc                                              23

<210>  6037
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  6037
aacaucaagg aagauggcau tt                                               22

<210>  6038
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  6038
aacaucaagg aagauggcat t                                                21

<210>  6039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  6039
aacaucaagg aagauggcat                                                  20

<210>  6040
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  6040
aacaucaagg aagauggca                                                   19

<210>  6041
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  6041
aacaucaagg aagauggc                                                    18

<210>  6042
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  6042
aacaucaagg aagaugg                                                     17

<210>  6043
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  6043
aacaucaagg aagatg                                                      16

<210>  6044
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  6044
aacaucaagg aagat                                                       15

<210>  6045
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  6045
aacaucaagg aaga                                                        14

<210>  6046
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  6046
aacaucaagg aag                                                         13

<210>  6047
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  6047
acaucaagga agauggcauu ucuag                                            25

<210>  6048
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  6048
acaucaagga agauggcauu ucta                                             24

<210>  6049
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  6049
acaucaagga agauggcauu uct                                              23

<210>  6050
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  6050
acaucaagga agauggcauu tc                                               22

<210>  6051
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  6051
acaucaagga agauggcaut t                                                21

<210>  6052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  6052
acaucaagga agauggcatt                                                  20

<210>  6053
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  6053
acaucaagga agauggcat                                                   19

<210>  6054
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  6054
acaucaagga agauggca                                                    18

<210>  6055
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  6055
acaucaagga agauggc                                                     17

<210>  6056
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  6056
acaucaagga agaugg                                                      16

<210>  6057
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  6057
acaucaagga agatg                                                       15

<210>  6058
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  6058
acaucaagga agat                                                        14

<210>  6059
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  6059
acaucaagga aga                                                         13

<210>  6060
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  6060
acaucaagga ag                                                          12

<210>  6061
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6061
caucaaggaa gauggcauuu cuag                                             24

<210>  6062
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6062
caucaaggaa gauggcauuu cta                                              23

<210>  6063
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6063
caucaaggaa gauggcauuu ct                                               22

<210>  6064
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6064
caucaaggaa gauggcauut c                                                21

<210>  6065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6065
caucaaggaa gauggcautt                                                  20

<210>  6066
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6066
caucaaggaa gauggcatt                                                   19

<210>  6067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6067
caucaaggaa gauggcat                                                    18

<210>  6068
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6068
caucaaggaa gauggca                                                     17

<210>  6069
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6069
caucaaggaa gauggc                                                      16

<210>  6070
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6070
caucaaggaa gaugg                                                       15

<210>  6071
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6071
caucaaggaa gatg                                                        14

<210>  6072
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6072
caucaaggaa gat                                                         13

<210>  6073
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6073
caucaaggaa ga                                                          12

<210>  6074
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6074
caucaaggaa g                                                           11

<210>  6075
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  6075
atcaaggaag auggcauuuc uag                                              23

<210>  6076
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  6076
atcaaggaag auggcauuuc ta                                               22

<210>  6077
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  6077
atcaaggaag auggcauuuc t                                                21

<210>  6078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  6078
atcaaggaag auggcauutc                                                  20

<210>  6079
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  6079
atcaaggaag auggcautt                                                   19

<210>  6080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  6080
atcaaggaag auggcatt                                                    18

<210>  6081
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  6081
atcaaggaag auggcat                                                     17

<210>  6082
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  6082
atcaaggaag auggca                                                      16

<210>  6083
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  6083
atcaaggaag auggc                                                       15

<210>  6084
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  6084
atcaaggaag augg                                                        14

<210>  6085
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  6085
atcaaggaag atg                                                         13

<210>  6086
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  6086
atcaaggaag at                                                          12

<210>  6087
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  6087
atcaaggaag a                                                           11

<210>  6088
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  6088
atcaaggaag                                                             10

<210>  6089
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6089
ggtaagttct gtccaagc                                                    18

<210>  6090
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6090
gtaagttctg tccaagcc                                                    18

<210>  6091
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6091
agtcggtaag ttctgtcc                                                    18

<210>  6092
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6092
ctgtccaagc ccggttga                                                    18

<210>  6093
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6093
taagttctgt ccaag                                                       15

<210>  6094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6094
ttctgtccaa gcccggttga                                                  20

<210>  6095
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6095
ttctgtccaa gcccggttg                                                   19

<210>  6096
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6096
ttctgtccaa gcccggtt                                                    18

<210>  6097
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6097
ttctgtccaa gcccggt                                                     17

<210>  6098
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6098
ttctgtccaa gcccgg                                                      16

<210>  6099
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6099
ttctgtccaa gcccg                                                       15

<210>  6100
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6100
ttctgtccaa gccc                                                        14

<210>  6101
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6101
ttctgtccaa gcc                                                         13

<210>  6102
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6102
ttctgtccaa gc                                                          12

<210>  6103
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6103
ttctgtccaa g                                                           11

<210>  6104
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6104
ttctgtccaa                                                             10

<210>  6105
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6105
ttctgtcca                                                              9

<210>  6106
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6106
ttctgtcc                                                               8

<210>  6107
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6107
tctgtccaag cccggttga                                                   19

<210>  6108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6108
tctgtccaag cccggttg                                                    18

<210>  6109
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6109
tctgtccaag cccggtt                                                     17

<210>  6110
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6110
tctgtccaag cccggt                                                      16

<210>  6111
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6111
tctgtccaag cccgg                                                       15

<210>  6112
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6112
tctgtccaag cccg                                                        14

<210>  6113
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6113
tctgtccaag ccc                                                         13

<210>  6114
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6114
tctgtccaag cc                                                          12

<210>  6115
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6115
tctgtccaag c                                                           11

<210>  6116
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6116
tctgtccaag                                                             10

<210>  6117
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6117
tctgtccaa                                                              9

<210>  6118
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6118
tctgtcca                                                               8

<210>  6119
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6119
ctgtccaagc ccggttg                                                     17

<210>  6120
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6120
ctgtccaagc ccggtt                                                      16

<210>  6121
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6121
ctgtccaagc ccggt                                                       15

<210>  6122
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6122
ctgtccaagc ccgg                                                        14

<210>  6123
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6123
ctgtccaagc ccg                                                         13

<210>  6124
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6124
ctgtccaagc cc                                                          12

<210>  6125
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6125
ctgtccaagc c                                                           11

<210>  6126
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6126
ctgtccaagc                                                             10

<210>  6127
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6127
ctgtccaag                                                              9

<210>  6128
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6128
ctgtccaa                                                               8

<210>  6129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6129
gttctgtcca agcccggttg                                                  20

<210>  6130
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6130
gttctgtcca agcccggtt                                                   19

<210>  6131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6131
gttctgtcca agcccggt                                                    18

<210>  6132
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6132
gttctgtcca agcccgg                                                     17

<210>  6133
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6133
gttctgtcca agcccg                                                      16

<210>  6134
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6134
gttctgtcca agccc                                                       15

<210>  6135
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6135
gttctgtcca agcc                                                        14

<210>  6136
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6136
gttctgtcca agc                                                         13

<210>  6137
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6137
gttctgtcca ag                                                          12

<210>  6138
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6138
gttctgtcca a                                                           11

<210>  6139
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6139
gttctgtcca                                                             10

<210>  6140
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6140
gttctgtcc                                                              9

<210>  6141
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6141
gttctgtc                                                               8

<210>  6142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6142
agttctgtcc aagcccggtt                                                  20

<210>  6143
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6143
agttctgtcc aagcccggt                                                   19

<210>  6144
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6144
agttctgtcc aagcccgg                                                    18

<210>  6145
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6145
agttctgtcc aagcccg                                                     17

<210>  6146
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6146
agttctgtcc aagccc                                                      16

<210>  6147
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6147
agttctgtcc aagcc                                                       15

<210>  6148
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6148
agttctgtcc aagc                                                        14

<210>  6149
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6149
agttctgtcc aag                                                         13

<210>  6150
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6150
agttctgtcc aa                                                          12

<210>  6151
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6151
agttctgtcc a                                                           11

<210>  6152
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6152
agttctgtcc                                                             10

<210>  6153
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6153
agttctgtc                                                              9

<210>  6154
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6154
agttctgt                                                               8

<210>  6155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6155
aagttctgtc caagcccggt                                                  20

<210>  6156
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6156
aagttctgtc caagcccgg                                                   19

<210>  6157
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6157
aagttctgtc caagcccg                                                    18

<210>  6158
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6158
aagttctgtc caagccc                                                     17

<210>  6159
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6159
aagttctgtc caagcc                                                      16

<210>  6160
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6160
aagttctgtc caagc                                                       15

<210>  6161
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6161
aagttctgtc caag                                                        14

<210>  6162
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6162
aagttctgtc caa                                                         13

<210>  6163
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6163
aagttctgtc ca                                                          12

<210>  6164
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6164
aagttctgtc c                                                           11

<210>  6165
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6165
aagttctgtc                                                             10

<210>  6166
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6166
aagttctgt                                                              9

<210>  6167
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6167
aagttctg                                                               8

<210>  6168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6168
taagttctgt ccaagcccgg                                                  20

<210>  6169
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6169
taagttctgt ccaagcccg                                                   19

<210>  6170
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6170
taagttctgt ccaagccc                                                    18

<210>  6171
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6171
taagttctgt ccaagcc                                                     17

<210>  6172
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6172
taagttctgt ccaagc                                                      16

<210>  6173
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6173
taagttctgt ccaa                                                        14

<210>  6174
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6174
taagttctgt cca                                                         13

<210>  6175
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6175
taagttctgt cc                                                          12

<210>  6176
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6176
taagttctgt c                                                           11

<210>  6177
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6177
taagttctgt                                                             10

<210>  6178
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6178
taagttctg                                                              9

<210>  6179
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6179
taagttct                                                               8

<210>  6180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6180
gtaagttctg tccaagcccg                                                  20

<210>  6181
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6181
gtaagttctg tccaagccc                                                   19

<210>  6182
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6182
gtaagttctg tccaagc                                                     17

<210>  6183
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6183
gtaagttctg tccaag                                                      16

<210>  6184
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6184
gtaagttctg tccaa                                                       15

<210>  6185
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6185
gtaagttctg tcca                                                        14

<210>  6186
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6186
gtaagttctg tcc                                                         13

<210>  6187
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6187
gtaagttctg tc                                                          12

<210>  6188
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6188
gtaagttctg t                                                           11

<210>  6189
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6189
gtaagttctg                                                             10

<210>  6190
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6190
gtaagttct                                                              9

<210>  6191
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6191
gtaagttc                                                               8

<210>  6192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6192
ggtaagttct gtccaagccc                                                  20

<210>  6193
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6193
ggtaagttct gtccaagcc                                                   19

<210>  6194
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6194
ggtaagttct gtccaag                                                     17

<210>  6195
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6195
ggtaagttct gtccaa                                                      16

<210>  6196
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6196
ggtaagttct gtcca                                                       15

<210>  6197
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6197
ggtaagttct gtcc                                                        14

<210>  6198
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6198
ggtaagttct gtc                                                         13

<210>  6199
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6199
ggtaagttct gt                                                          12

<210>  6200
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6200
ggtaagttct g                                                           11

<210>  6201
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6201
ggtaagttct                                                             10

<210>  6202
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6202
ggtaagttc                                                              9

<210>  6203
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6203
ggtaagtt                                                               8

<210>  6204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6204
cggtaagttc tgtccaagcc                                                  20

<210>  6205
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6205
cggtaagttc tgtccaagc                                                   19

<210>  6206
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6206
cggtaagttc tgtccaag                                                    18

<210>  6207
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6207
cggtaagttc tgtccaa                                                     17

<210>  6208
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6208
cggtaagttc tgtcca                                                      16

<210>  6209
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6209
cggtaagttc tgtcc                                                       15

<210>  6210
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6210
cggtaagttc tgtc                                                        14

<210>  6211
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6211
cggtaagttc tgt                                                         13

<210>  6212
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6212
cggtaagttc tg                                                          12

<210>  6213
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6213
cggtaagttc t                                                           11

<210>  6214
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6214
cggtaagttc                                                             10

<210>  6215
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6215
cggtaagtt                                                              9

<210>  6216
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6216
cggtaagt                                                               8

<210>  6217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6217
tcggtaagtt ctgtccaagc                                                  20

<210>  6218
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6218
tcggtaagtt ctgtccaag                                                   19

<210>  6219
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6219
tcggtaagtt ctgtccaa                                                    18

<210>  6220
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6220
tcggtaagtt ctgtcca                                                     17

<210>  6221
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6221
tcggtaagtt ctgtcc                                                      16

<210>  6222
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6222
tcggtaagtt ctgtc                                                       15

<210>  6223
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6223
tcggtaagtt ctgt                                                        14

<210>  6224
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6224
tcggtaagtt ctg                                                         13

<210>  6225
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6225
tcggtaagtt ct                                                          12

<210>  6226
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6226
tcggtaagtt c                                                           11

<210>  6227
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6227
tcggtaagtt                                                             10

<210>  6228
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6228
tcggtaagt                                                              9

<210>  6229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6229
gtcggtaagt tctgtccaag                                                  20

<210>  6230
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6230
gtcggtaagt tctgtccaa                                                   19

<210>  6231
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6231
gtcggtaagt tctgtcca                                                    18

<210>  6232
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6232
gtcggtaagt tctgtcc                                                     17

<210>  6233
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6233
gtcggtaagt tctgtc                                                      16

<210>  6234
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6234
gtcggtaagt tctgt                                                       15

<210>  6235
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6235
gtcggtaagt tctg                                                        14

<210>  6236
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6236
gtcggtaagt tct                                                         13

<210>  6237
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6237
gtcggtaagt tc                                                          12

<210>  6238
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6238
gtcggtaagt t                                                           11

<210>  6239
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6239
gtcggtaagt                                                             10

<210>  6240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6240
agtcggtaag ttctgtccaa                                                  20

<210>  6241
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6241
agtcggtaag ttctgtcca                                                   19

<210>  6242
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6242
agtcggtaag ttctgtc                                                     17

<210>  6243
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6243
agtcggtaag ttctgt                                                      16

<210>  6244
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6244
agtcggtaag ttctg                                                       15

<210>  6245
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6245
agtcggtaag ttct                                                        14

<210>  6246
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6246
agtcggtaag ttc                                                         13

<210>  6247
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6247
agtcggtaag tt                                                          12

<210>  6248
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6248
agtcggtaag t                                                           11

<210>  6249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6249
cagtcggtaa gttctgtcca                                                  20

<210>  6250
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6250
cagtcggtaa gttctgtcc                                                   19

<210>  6251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6251
cagtcggtaa gttctgtc                                                    18

<210>  6252
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6252
cagtcggtaa gttctgt                                                     17

<210>  6253
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6253
cagtcggtaa gttctg                                                      16

<210>  6254
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6254
cagtcggtaa gttct                                                       15

<210>  6255
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6255
cagtcggtaa gttc                                                        14

<210>  6256
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6256
cagtcggtaa gtt                                                         13

<210>  6257
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6257
cagtcggtaa gt                                                          12

<210>  6258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6258
ccagtcggta agttctgtcc                                                  20

<210>  6259
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6259
ccagtcggta agttctgtc                                                   19

<210>  6260
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6260
ccagtcggta agttctgt                                                    18

<210>  6261
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6261
ccagtcggta agttctg                                                     17

<210>  6262
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6262
ccagtcggta agttct                                                      16

<210>  6263
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6263
ccagtcggta agttc                                                       15

<210>  6264
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6264
ccagtcggta agtt                                                        14

<210>  6265
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6265
ccagtcggta agt                                                         13

<210>  6266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6266
gccagtcggt aagttctgtc                                                  20

<210>  6267
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6267
gccagtcggt aagttctgt                                                   19

<210>  6268
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6268
gccagtcggt aagttctg                                                    18

<210>  6269
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6269
gccagtcggt aagttct                                                     17

<210>  6270
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6270
gccagtcggt aagttc                                                      16

<210>  6271
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6271
gccagtcggt aagtt                                                       15

<210>  6272
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6272
gccagtcggt aagt                                                        14

<210>  6273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6273
tcaaggaaga tggcatttct                                                  20

<210>  6274
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6274
tcaaggaaga tggcatttct ag                                               22

<210>  6275
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6275
tcaaggaaga tggcat                                                      16

<210>  6276
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6276
gaagatggca tttct                                                       15

<210>  6277
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6277
tcaaggaaga tggcatttct a                                                21

<210>  6278
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6278
tcaaggaaga tggcatttc                                                   19

<210>  6279
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6279
tcaaggaaga tggcattt                                                    18

<210>  6280
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6280
tcaaggaaga tggcatt                                                     17

<210>  6281
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6281
tcaaggaaga tggca                                                       15

<210>  6282
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6282
tcaaggaaga tggc                                                        14

<210>  6283
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6283
tcaaggaaga tgg                                                         13

<210>  6284
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6284
tcaaggaaga tg                                                          12

<210>  6285
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6285
tcaaggaaga t                                                           11

<210>  6286
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6286
tcaaggaaga                                                             10

<210>  6287
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6287
tcaaggaag                                                              9

<210>  6288
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6288
caaggaagat ggcatttcta g                                                21

<210>  6289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6289
caaggaagat ggcatttcta                                                  20

<210>  6290
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6290
caaggaagat ggcatttct                                                   19

<210>  6291
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6291
caaggaagat ggcatttc                                                    18

<210>  6292
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6292
caaggaagat ggcattt                                                     17

<210>  6293
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6293
caaggaagat ggcatt                                                      16

<210>  6294
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6294
caaggaagat ggcat                                                       15

<210>  6295
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6295
caaggaagat ggca                                                        14

<210>  6296
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6296
caaggaagat ggc                                                         13

<210>  6297
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6297
caaggaagat gg                                                          12

<210>  6298
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6298
caaggaagat g                                                           11

<210>  6299
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6299
caaggaagat                                                             10

<210>  6300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6300
aaggaagatg gcatttctag                                                  20

<210>  6301
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6301
aaggaagatg gcatttcta                                                   19

<210>  6302
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6302
aaggaagatg gcatttct                                                    18

<210>  6303
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6303
aaggaagatg gcatttc                                                     17

<210>  6304
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6304
aaggaagatg gcattt                                                      16

<210>  6305
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6305
aaggaagatg gcatt                                                       15

<210>  6306
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6306
aaggaagatg gcat                                                        14

<210>  6307
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6307
aaggaagatg gca                                                         13

<210>  6308
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6308
aaggaagatg gc                                                          12

<210>  6309
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6309
aaggaagatg g                                                           11

<210>  6310
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6310
aaggaagatg                                                             10

<210>  6311
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6311
aaggaagat                                                              9

<210>  6312
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6312
aggaagatgg catttctag                                                   19

<210>  6313
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6313
aggaagatgg catttcta                                                    18

<210>  6314
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6314
aggaagatgg catttct                                                     17

<210>  6315
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6315
aggaagatgg catttc                                                      16

<210>  6316
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6316
aggaagatgg cattt                                                       15

<210>  6317
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6317
aggaagatgg catt                                                        14

<210>  6318
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6318
aggaagatgg cat                                                         13

<210>  6319
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6319
aggaagatgg ca                                                          12

<210>  6320
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6320
aggaagatgg                                                             10

<210>  6321
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6321
aggaagatg                                                              9

<210>  6322
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6322
aggaagat                                                               8

<210>  6323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6323
ggaagatggc atttctag                                                    18

<210>  6324
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6324
ggaagatggc atttcta                                                     17

<210>  6325
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6325
ggaagatggc atttct                                                      16

<210>  6326
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6326
ggaagatggc atttc                                                       15

<210>  6327
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6327
ggaagatggc attt                                                        14

<210>  6328
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6328
ggaagatggc att                                                         13

<210>  6329
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6329
ggaagatggc at                                                          12

<210>  6330
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6330
ggaagatggc a                                                           11

<210>  6331
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6331
ggaagatggc                                                             10

<210>  6332
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6332
ggaagatg                                                               8

<210>  6333
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6333
gaagatggca tttctag                                                     17

<210>  6334
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6334
gaagatggca tttcta                                                      16

<210>  6335
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6335
gaagatggca tttc                                                        14

<210>  6336
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6336
gaagatggca ttt                                                         13

<210>  6337
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6337
gaagatggca tt                                                          12

<210>  6338
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6338
gaagatggca t                                                           11

<210>  6339
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6339
gaagatggca                                                             10

<210>  6340
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6340
gaagatggc                                                              9

<210>  6341
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6341
gaagatgg                                                               8

<210>  6342
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6342
aagatggcat ttctag                                                      16

<210>  6343
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6343
aagatggcat ttcta                                                       15

<210>  6344
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6344
aagatggcat ttct                                                        14

<210>  6345
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6345
aagatggcat ttc                                                         13

<210>  6346
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6346
aagatggcat tt                                                          12

<210>  6347
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6347
aagatggcat t                                                           11

<210>  6348
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6348
aagatggcat                                                             10

<210>  6349
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6349
aagatggca                                                              9

<210>  6350
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6350
aagatggc                                                               8

<210>  6351
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6351
agatggcatt tctag                                                       15

<210>  6352
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6352
agatggcatt tcta                                                        14

<210>  6353
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6353
agatggcatt tct                                                         13

<210>  6354
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6354
agatggcatt tc                                                          12

<210>  6355
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6355
agatggcatt t                                                           11

<210>  6356
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6356
agatggcatt                                                             10

<210>  6357
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6357
agatggcat                                                              9

<210>  6358
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6358
agatggca                                                               8

<210>  6359
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6359
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  6360
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6360
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  6361
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6361
ctccaacatc aaggaagatg gcatttct                                         28

<210>  6362
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6362
ctccaacatc aaggaagatg gcatttc                                          27

<210>  6363
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6363
ctccaacatc aaggaagatg gcattt                                           26

<210>  6364
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6364
ctccaacatc aaggaagatg gcatt                                            25

<210>  6365
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6365
ctccaacatc aaggaagatg gcat                                             24

<210>  6366
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6366
ctccaacatc aaggaagatg gca                                              23

<210>  6367
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6367
ctccaacatc aaggaagatg gc                                               22

<210>  6368
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6368
ctccaacatc aaggaagatg g                                                21

<210>  6369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6369
ctccaacatc aaggaagatg                                                  20

<210>  6370
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6370
ctccaacatc aaggaagat                                                   19

<210>  6371
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6371
ctccaacatc aaggaaga                                                    18

<210>  6372
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6372
ctccaacatc aaggaag                                                     17

<210>  6373
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6373
tccaacatca aggaagatgg catttctag                                        29

<210>  6374
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6374
tccaacatca aggaagatgg catttcta                                         28

<210>  6375
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6375
tccaacatca aggaagatgg catttct                                          27

<210>  6376
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6376
tccaacatca aggaagatgg catttc                                           26

<210>  6377
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6377
tccaacatca aggaagatgg cattt                                            25

<210>  6378
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6378
tccaacatca aggaagatgg catt                                             24

<210>  6379
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6379
tccaacatca aggaagatgg cat                                              23

<210>  6380
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6380
tccaacatca aggaagatgg ca                                               22

<210>  6381
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6381
tccaacatca aggaagatgg c                                                21

<210>  6382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6382
tccaacatca aggaagatgg                                                  20

<210>  6383
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6383
tccaacatca aggaagatg                                                   19

<210>  6384
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6384
tccaacatca aggaagat                                                    18

<210>  6385
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6385
tccaacatca aggaaga                                                     17

<210>  6386
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6386
tccaacatca aggaag                                                      16

<210>  6387
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6387
ccaacatcaa ggaagatggc atttctag                                         28

<210>  6388
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6388
ccaacatcaa ggaagatggc atttcta                                          27

<210>  6389
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6389
ccaacatcaa ggaagatggc atttct                                           26

<210>  6390
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6390
ccaacatcaa ggaagatggc atttc                                            25

<210>  6391
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6391
ccaacatcaa ggaagatggc attt                                             24

<210>  6392
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6392
ccaacatcaa ggaagatggc att                                              23

<210>  6393
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6393
ccaacatcaa ggaagatggc at                                               22

<210>  6394
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6394
ccaacatcaa ggaagatggc a                                                21

<210>  6395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6395
ccaacatcaa ggaagatggc                                                  20

<210>  6396
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6396
ccaacatcaa ggaagatgg                                                   19

<210>  6397
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6397
ccaacatcaa ggaagatg                                                    18

<210>  6398
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6398
ccaacatcaa ggaagat                                                     17

<210>  6399
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6399
ccaacatcaa ggaaga                                                      16

<210>  6400
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6400
ccaacatcaa ggaag                                                       15

<210>  6401
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6401
caacatcaag gaagatggca tttctag                                          27

<210>  6402
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6402
caacatcaag gaagatggca tttcta                                           26

<210>  6403
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6403
caacatcaag gaagatggca tttct                                            25

<210>  6404
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6404
caacatcaag gaagatggca tttc                                             24

<210>  6405
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6405
caacatcaag gaagatggca ttt                                              23

<210>  6406
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6406
caacatcaag gaagatggca tt                                               22

<210>  6407
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6407
caacatcaag gaagatggca t                                                21

<210>  6408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6408
caacatcaag gaagatggca                                                  20

<210>  6409
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6409
caacatcaag gaagatggc                                                   19

<210>  6410
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6410
caacatcaag gaagatgg                                                    18

<210>  6411
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6411
caacatcaag gaagatg                                                     17

<210>  6412
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6412
caacatcaag gaagat                                                      16

<210>  6413
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6413
caacatcaag gaaga                                                       15

<210>  6414
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6414
caacatcaag gaag                                                        14

<210>  6415
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6415
aacatcaagg aagatggcat ttctag                                           26

<210>  6416
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6416
aacatcaagg aagatggcat ttcta                                            25

<210>  6417
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6417
aacatcaagg aagatggcat ttct                                             24

<210>  6418
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6418
aacatcaagg aagatggcat ttc                                              23

<210>  6419
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6419
aacatcaagg aagatggcat tt                                               22

<210>  6420
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6420
aacatcaagg aagatggcat t                                                21

<210>  6421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6421
aacatcaagg aagatggcat                                                  20

<210>  6422
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6422
aacatcaagg aagatggca                                                   19

<210>  6423
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6423
aacatcaagg aagatggc                                                    18

<210>  6424
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6424
aacatcaagg aagatgg                                                     17

<210>  6425
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6425
aacatcaagg aagatg                                                      16

<210>  6426
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6426
aacatcaagg aagat                                                       15

<210>  6427
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6427
aacatcaagg aaga                                                        14

<210>  6428
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6428
aacatcaagg aag                                                         13

<210>  6429
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6429
acatcaagga agatggcatt tctag                                            25

<210>  6430
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6430
acatcaagga agatggcatt tcta                                             24

<210>  6431
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6431
acatcaagga agatggcatt tct                                              23

<210>  6432
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6432
acatcaagga agatggcatt tc                                               22

<210>  6433
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6433
acatcaagga agatggcatt t                                                21

<210>  6434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6434
acatcaagga agatggcatt                                                  20

<210>  6435
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6435
acatcaagga agatggcat                                                   19

<210>  6436
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6436
acatcaagga agatggca                                                    18

<210>  6437
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6437
acatcaagga agatggc                                                     17

<210>  6438
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6438
acatcaagga agatgg                                                      16

<210>  6439
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6439
acatcaagga agatg                                                       15

<210>  6440
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6440
acatcaagga agat                                                        14

<210>  6441
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6441
acatcaagga aga                                                         13

<210>  6442
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6442
acatcaagga ag                                                          12

<210>  6443
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6443
catcaaggaa gatggcattt ctag                                             24

<210>  6444
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6444
catcaaggaa gatggcattt cta                                              23

<210>  6445
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6445
catcaaggaa gatggcattt ct                                               22

<210>  6446
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6446
catcaaggaa gatggcattt c                                                21

<210>  6447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6447
catcaaggaa gatggcattt                                                  20

<210>  6448
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6448
catcaaggaa gatggcatt                                                   19

<210>  6449
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6449
catcaaggaa gatggcat                                                    18

<210>  6450
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6450
catcaaggaa gatggca                                                     17

<210>  6451
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6451
catcaaggaa gatggc                                                      16

<210>  6452
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6452
catcaaggaa gatgg                                                       15

<210>  6453
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6453
catcaaggaa gatg                                                        14

<210>  6454
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6454
catcaaggaa gat                                                         13

<210>  6455
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6455
catcaaggaa ga                                                          12

<210>  6456
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6456
catcaaggaa g                                                           11

<210>  6457
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6457
atcaaggaag atggcatttc tag                                              23

<210>  6458
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6458
atcaaggaag atggcatttc ta                                               22

<210>  6459
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6459
atcaaggaag atggcatttc t                                                21

<210>  6460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6460
atcaaggaag atggcatttc                                                  20

<210>  6461
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6461
atcaaggaag atggcattt                                                   19

<210>  6462
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6462
atcaaggaag atggcatt                                                    18

<210>  6463
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6463
atcaaggaag atggcat                                                     17

<210>  6464
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6464
atcaaggaag atggca                                                      16

<210>  6465
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6465
atcaaggaag atggc                                                       15

<210>  6466
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6466
atcaaggaag atgg                                                        14

<210>  6467
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6467
atcaaggaag atg                                                         13

<210>  6468
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6468
atcaaggaag at                                                          12

<210>  6469
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6469
atcaaggaag a                                                           11

<210>  6470
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  6470
atcaaggaag                                                             10

<210>  6471
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6471
ggtaagttct gtccaagc                                                    18

<210>  6472
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6472
gtaagttctg tccaagcc                                                    18

<210>  6473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6473
agtcggtaag ttctgtcc                                                    18

<210>  6474
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6474
ctgtccaagc ccggttga                                                    18

<210>  6475
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6475
taagttctgt ccaag                                                       15

<210>  6476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6476
ttctgtccaa gcccggttga                                                  20

<210>  6477
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6477
ttctgtccaa gcccggttg                                                   19

<210>  6478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6478
ttctgtccaa gcccggtt                                                    18

<210>  6479
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6479
ttctgtccaa gcccggt                                                     17

<210>  6480
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6480
ttctgtccaa gcccgg                                                      16

<210>  6481
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6481
ttctgtccaa gcccg                                                       15

<210>  6482
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6482
ttctgtccaa gccc                                                        14

<210>  6483
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6483
ttctgtccaa gcc                                                         13

<210>  6484
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6484
ttctgtccaa gc                                                          12

<210>  6485
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6485
ttctgtccaa g                                                           11

<210>  6486
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6486
ttctgtccaa                                                             10

<210>  6487
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6487
ttctgtcca                                                              9

<210>  6488
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6488
ttctgtcc                                                               8

<210>  6489
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6489
tctgtccaag cccggttga                                                   19

<210>  6490
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6490
tctgtccaag cccggttg                                                    18

<210>  6491
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6491
tctgtccaag cccggtt                                                     17

<210>  6492
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6492
tctgtccaag cccggt                                                      16

<210>  6493
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6493
tctgtccaag cccgg                                                       15

<210>  6494
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6494
tctgtccaag cccg                                                        14

<210>  6495
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6495
tctgtccaag ccc                                                         13

<210>  6496
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6496
tctgtccaag cc                                                          12

<210>  6497
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6497
tctgtccaag c                                                           11

<210>  6498
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6498
tctgtccaag                                                             10

<210>  6499
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6499
tctgtccaa                                                              9

<210>  6500
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6500
tctgtcca                                                               8

<210>  6501
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6501
ctgtccaagc ccggttg                                                     17

<210>  6502
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6502
ctgtccaagc ccggtt                                                      16

<210>  6503
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6503
ctgtccaagc ccggt                                                       15

<210>  6504
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6504
ctgtccaagc ccgg                                                        14

<210>  6505
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6505
ctgtccaagc ccg                                                         13

<210>  6506
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6506
ctgtccaagc cc                                                          12

<210>  6507
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6507
ctgtccaagc c                                                           11

<210>  6508
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6508
ctgtccaagc                                                             10

<210>  6509
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6509
ctgtccaag                                                              9

<210>  6510
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6510
ctgtccaa                                                               8

<210>  6511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6511
gttctgtcca agcccggttg                                                  20

<210>  6512
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6512
gttctgtcca agcccggtt                                                   19

<210>  6513
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6513
gttctgtcca agcccggt                                                    18

<210>  6514
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6514
gttctgtcca agcccgg                                                     17

<210>  6515
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6515
gttctgtcca agcccg                                                      16

<210>  6516
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6516
gttctgtcca agccc                                                       15

<210>  6517
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6517
gttctgtcca agcc                                                        14

<210>  6518
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6518
gttctgtcca agc                                                         13

<210>  6519
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6519
gttctgtcca ag                                                          12

<210>  6520
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6520
gttctgtcca a                                                           11

<210>  6521
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6521
gttctgtcca                                                             10

<210>  6522
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6522
gttctgtcc                                                              9

<210>  6523
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6523
gttctgtc                                                               8

<210>  6524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6524
agttctgtcc aagcccggtt                                                  20

<210>  6525
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6525
agttctgtcc aagcccggt                                                   19

<210>  6526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6526
agttctgtcc aagcccgg                                                    18

<210>  6527
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6527
agttctgtcc aagcccg                                                     17

<210>  6528
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6528
agttctgtcc aagccc                                                      16

<210>  6529
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6529
agttctgtcc aagcc                                                       15

<210>  6530
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6530
agttctgtcc aagc                                                        14

<210>  6531
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6531
agttctgtcc aag                                                         13

<210>  6532
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6532
agttctgtcc aa                                                          12

<210>  6533
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6533
agttctgtcc a                                                           11

<210>  6534
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6534
agttctgtcc                                                             10

<210>  6535
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6535
agttctgtc                                                              9

<210>  6536
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6536
agttctgt                                                               8

<210>  6537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6537
aagttctgtc caagcccggt                                                  20

<210>  6538
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6538
aagttctgtc caagcccgg                                                   19

<210>  6539
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6539
aagttctgtc caagcccg                                                    18

<210>  6540
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6540
aagttctgtc caagccc                                                     17

<210>  6541
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6541
aagttctgtc caagcc                                                      16

<210>  6542
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6542
aagttctgtc caagc                                                       15

<210>  6543
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6543
aagttctgtc caag                                                        14

<210>  6544
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6544
aagttctgtc caa                                                         13

<210>  6545
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6545
aagttctgtc ca                                                          12

<210>  6546
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6546
aagttctgtc c                                                           11

<210>  6547
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6547
aagttctgtc                                                             10

<210>  6548
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6548
aagttctgt                                                              9

<210>  6549
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6549
aagttctg                                                               8

<210>  6550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6550
taagttctgt ccaagcccgg                                                  20

<210>  6551
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6551
taagttctgt ccaagcccg                                                   19

<210>  6552
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6552
taagttctgt ccaagccc                                                    18

<210>  6553
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6553
taagttctgt ccaagcc                                                     17

<210>  6554
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6554
taagttctgt ccaagc                                                      16

<210>  6555
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6555
taagttctgt ccaa                                                        14

<210>  6556
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6556
taagttctgt cca                                                         13

<210>  6557
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6557
taagttctgt cc                                                          12

<210>  6558
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6558
taagttctgt c                                                           11

<210>  6559
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6559
taagttctgt                                                             10

<210>  6560
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6560
taagttctg                                                              9

<210>  6561
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6561
taagttct                                                               8

<210>  6562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6562
gtaagttctg tccaagcccg                                                  20

<210>  6563
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6563
gtaagttctg tccaagccc                                                   19

<210>  6564
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6564
gtaagttctg tccaagc                                                     17

<210>  6565
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6565
gtaagttctg tccaag                                                      16

<210>  6566
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6566
gtaagttctg tccaa                                                       15

<210>  6567
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6567
gtaagttctg tcca                                                        14

<210>  6568
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6568
gtaagttctg tcc                                                         13

<210>  6569
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6569
gtaagttctg tc                                                          12

<210>  6570
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6570
gtaagttctg t                                                           11

<210>  6571
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6571
gtaagttctg                                                             10

<210>  6572
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6572
gtaagttct                                                              9

<210>  6573
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6573
gtaagttc                                                               8

<210>  6574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6574
ggtaagttct gtccaagccc                                                  20

<210>  6575
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6575
ggtaagttct gtccaagcc                                                   19

<210>  6576
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6576
ggtaagttct gtccaag                                                     17

<210>  6577
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6577
ggtaagttct gtccaa                                                      16

<210>  6578
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6578
ggtaagttct gtcca                                                       15

<210>  6579
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6579
ggtaagttct gtcc                                                        14

<210>  6580
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6580
ggtaagttct gtc                                                         13

<210>  6581
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6581
ggtaagttct gt                                                          12

<210>  6582
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6582
ggtaagttct g                                                           11

<210>  6583
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6583
ggtaagttct                                                             10

<210>  6584
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6584
ggtaagttc                                                              9

<210>  6585
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6585
ggtaagtt                                                               8

<210>  6586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6586
cggtaagttc tgtccaagcc                                                  20

<210>  6587
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6587
cggtaagttc tgtccaagc                                                   19

<210>  6588
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6588
cggtaagttc tgtccaag                                                    18

<210>  6589
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6589
cggtaagttc tgtccaa                                                     17

<210>  6590
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6590
cggtaagttc tgtcca                                                      16

<210>  6591
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6591
cggtaagttc tgtcc                                                       15

<210>  6592
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6592
cggtaagttc tgtc                                                        14

<210>  6593
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6593
cggtaagttc tgt                                                         13

<210>  6594
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6594
cggtaagttc tg                                                          12

<210>  6595
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6595
cggtaagttc t                                                           11

<210>  6596
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6596
cggtaagttc                                                             10

<210>  6597
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6597
cggtaagtt                                                              9

<210>  6598
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6598
cggtaagt                                                               8

<210>  6599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6599
tcggtaagtt ctgtccaagc                                                  20

<210>  6600
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6600
tcggtaagtt ctgtccaag                                                   19

<210>  6601
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6601
tcggtaagtt ctgtccaa                                                    18

<210>  6602
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6602
tcggtaagtt ctgtcca                                                     17

<210>  6603
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6603
tcggtaagtt ctgtcc                                                      16

<210>  6604
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6604
tcggtaagtt ctgtc                                                       15

<210>  6605
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6605
tcggtaagtt ctgt                                                        14

<210>  6606
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6606
tcggtaagtt ctg                                                         13

<210>  6607
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6607
tcggtaagtt ct                                                          12

<210>  6608
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6608
tcggtaagtt c                                                           11

<210>  6609
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6609
tcggtaagtt                                                             10

<210>  6610
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6610
tcggtaagt                                                              9

<210>  6611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6611
gtcggtaagt tctgtccaag                                                  20

<210>  6612
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6612
gtcggtaagt tctgtccaa                                                   19

<210>  6613
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6613
gtcggtaagt tctgtcca                                                    18

<210>  6614
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6614
gtcggtaagt tctgtcc                                                     17

<210>  6615
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6615
gtcggtaagt tctgtc                                                      16

<210>  6616
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6616
gtcggtaagt tctgt                                                       15

<210>  6617
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6617
gtcggtaagt tctg                                                        14

<210>  6618
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6618
gtcggtaagt tct                                                         13

<210>  6619
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6619
gtcggtaagt tc                                                          12

<210>  6620
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6620
gtcggtaagt t                                                           11

<210>  6621
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6621
gtcggtaagt                                                             10

<210>  6622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6622
agtcggtaag ttctgtccaa                                                  20

<210>  6623
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6623
agtcggtaag ttctgtcca                                                   19

<210>  6624
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6624
agtcggtaag ttctgtc                                                     17

<210>  6625
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6625
agtcggtaag ttctgt                                                      16

<210>  6626
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6626
agtcggtaag ttctg                                                       15

<210>  6627
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6627
agtcggtaag ttct                                                        14

<210>  6628
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6628
agtcggtaag ttc                                                         13

<210>  6629
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6629
agtcggtaag tt                                                          12

<210>  6630
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6630
agtcggtaag t                                                           11

<210>  6631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6631
cagtcggtaa gttctgtcca                                                  20

<210>  6632
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6632
cagtcggtaa gttctgtcc                                                   19

<210>  6633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6633
cagtcggtaa gttctgtc                                                    18

<210>  6634
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6634
cagtcggtaa gttctgt                                                     17

<210>  6635
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6635
cagtcggtaa gttctg                                                      16

<210>  6636
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6636
cagtcggtaa gttct                                                       15

<210>  6637
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6637
cagtcggtaa gttc                                                        14

<210>  6638
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6638
cagtcggtaa gtt                                                         13

<210>  6639
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6639
cagtcggtaa gt                                                          12

<210>  6640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6640
ccagtcggta agttctgtcc                                                  20

<210>  6641
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6641
ccagtcggta agttctgtc                                                   19

<210>  6642
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6642
ccagtcggta agttctgt                                                    18

<210>  6643
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6643
ccagtcggta agttctg                                                     17

<210>  6644
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6644
ccagtcggta agttct                                                      16

<210>  6645
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6645
ccagtcggta agttc                                                       15

<210>  6646
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6646
ccagtcggta agtt                                                        14

<210>  6647
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6647
ccagtcggta agt                                                         13

<210>  6648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6648
gccagtcggt aagttctgtc                                                  20

<210>  6649
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6649
gccagtcggt aagttctgt                                                   19

<210>  6650
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6650
gccagtcggt aagttctg                                                    18

<210>  6651
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6651
gccagtcggt aagttct                                                     17

<210>  6652
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6652
gccagtcggt aagttc                                                      16

<210>  6653
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6653
gccagtcggt aagtt                                                       15

<210>  6654
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6654
gccagtcggt aagt                                                        14

<210>  6655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6655
tcaaggaaga tggcatttct                                                  20

<210>  6656
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6656
tcaaggaaga tggcatttct ag                                               22

<210>  6657
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6657
tcaaggaaga tggcat                                                      16

<210>  6658
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6658
gaagatggca tttct                                                       15

<210>  6659
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6659
tcaaggaaga tggcatttct a                                                21

<210>  6660
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6660
tcaaggaaga tggcatttc                                                   19

<210>  6661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6661
tcaaggaaga tggcattt                                                    18

<210>  6662
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6662
tcaaggaaga tggcatt                                                     17

<210>  6663
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6663
tcaaggaaga tggca                                                       15

<210>  6664
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6664
tcaaggaaga tggc                                                        14

<210>  6665
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6665
tcaaggaaga tgg                                                         13

<210>  6666
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6666
tcaaggaaga tg                                                          12

<210>  6667
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6667
tcaaggaaga t                                                           11

<210>  6668
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6668
tcaaggaaga                                                             10

<210>  6669
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6669
tcaaggaag                                                              9

<210>  6670
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6670
caaggaagat ggcatttcta g                                                21

<210>  6671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6671
caaggaagat ggcatttcta                                                  20

<210>  6672
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6672
caaggaagat ggcatttct                                                   19

<210>  6673
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6673
caaggaagat ggcatttc                                                    18

<210>  6674
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6674
caaggaagat ggcattt                                                     17

<210>  6675
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6675
caaggaagat ggcatt                                                      16

<210>  6676
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6676
caaggaagat ggcat                                                       15

<210>  6677
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6677
caaggaagat ggca                                                        14

<210>  6678
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6678
caaggaagat ggc                                                         13

<210>  6679
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6679
caaggaagat gg                                                          12

<210>  6680
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6680
caaggaagat g                                                           11

<210>  6681
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6681
caaggaagat                                                             10

<210>  6682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6682
aaggaagatg gcatttctag                                                  20

<210>  6683
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6683
aaggaagatg gcatttcta                                                   19

<210>  6684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6684
aaggaagatg gcatttct                                                    18

<210>  6685
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6685
aaggaagatg gcatttc                                                     17

<210>  6686
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6686
aaggaagatg gcattt                                                      16

<210>  6687
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6687
aaggaagatg gcatt                                                       15

<210>  6688
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6688
aaggaagatg gcat                                                        14

<210>  6689
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6689
aaggaagatg gca                                                         13

<210>  6690
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6690
aaggaagatg gc                                                          12

<210>  6691
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6691
aaggaagatg g                                                           11

<210>  6692
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6692
aaggaagatg                                                             10

<210>  6693
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6693
aaggaagat                                                              9

<210>  6694
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6694
aggaagatgg catttctag                                                   19

<210>  6695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6695
aggaagatgg catttcta                                                    18

<210>  6696
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6696
aggaagatgg catttct                                                     17

<210>  6697
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6697
aggaagatgg catttc                                                      16

<210>  6698
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6698
aggaagatgg cattt                                                       15

<210>  6699
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6699
aggaagatgg catt                                                        14

<210>  6700
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6700
aggaagatgg cat                                                         13

<210>  6701
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6701
aggaagatgg ca                                                          12

<210>  6702
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6702
aggaagatgg                                                             10

<210>  6703
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6703
aggaagatg                                                              9

<210>  6704
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6704
aggaagat                                                               8

<210>  6705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6705
ggaagatggc atttctag                                                    18

<210>  6706
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6706
ggaagatggc atttcta                                                     17

<210>  6707
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6707
ggaagatggc atttct                                                      16

<210>  6708
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6708
ggaagatggc atttc                                                       15

<210>  6709
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6709
ggaagatggc attt                                                        14

<210>  6710
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6710
ggaagatggc att                                                         13

<210>  6711
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6711
ggaagatggc at                                                          12

<210>  6712
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6712
ggaagatggc a                                                           11

<210>  6713
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6713
ggaagatggc                                                             10

<210>  6714
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6714
ggaagatg                                                               8

<210>  6715
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6715
gaagatggca tttctag                                                     17

<210>  6716
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6716
gaagatggca tttcta                                                      16

<210>  6717
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6717
gaagatggca tttc                                                        14

<210>  6718
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6718
gaagatggca ttt                                                         13

<210>  6719
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6719
gaagatggca tt                                                          12

<210>  6720
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6720
gaagatggca t                                                           11

<210>  6721
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6721
gaagatggca                                                             10

<210>  6722
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6722
gaagatggc                                                              9

<210>  6723
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6723
gaagatgg                                                               8

<210>  6724
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6724
aagatggcat ttctag                                                      16

<210>  6725
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6725
aagatggcat ttcta                                                       15

<210>  6726
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6726
aagatggcat ttct                                                        14

<210>  6727
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6727
aagatggcat ttc                                                         13

<210>  6728
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6728
aagatggcat tt                                                          12

<210>  6729
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6729
aagatggcat t                                                           11

<210>  6730
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6730
aagatggcat                                                             10

<210>  6731
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6731
aagatggca                                                              9

<210>  6732
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6732
aagatggc                                                               8

<210>  6733
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6733
agatggcatt tctag                                                       15

<210>  6734
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6734
agatggcatt tcta                                                        14

<210>  6735
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6735
agatggcatt tct                                                         13

<210>  6736
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6736
agatggcatt tc                                                          12

<210>  6737
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6737
agatggcatt t                                                           11

<210>  6738
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6738
agatggcatt                                                             10

<210>  6739
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6739
agatggcat                                                              9

<210>  6740
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6740
agatggca                                                               8

<210>  6741
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  6741
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  6742
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  6742
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  6743
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  6743
ctccaacatc aaggaagatg gcatttct                                         28

<210>  6744
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  6744
ctccaacatc aaggaagatg gcatttc                                          27

<210>  6745
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6745
ctccaacatc aaggaagatg gcattt                                           26

<210>  6746
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6746
ctccaacatc aaggaagatg gcatt                                            25

<210>  6747
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6747
ctccaacatc aaggaagatg gcat                                             24

<210>  6748
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6748
ctccaacatc aaggaagatg gca                                              23

<210>  6749
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6749
ctccaacatc aaggaagatg gc                                               22

<210>  6750
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6750
ctccaacatc aaggaagatg g                                                21

<210>  6751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6751
ctccaacatc aaggaagatg                                                  20

<210>  6752
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6752
ctccaacatc aaggaagat                                                   19

<210>  6753
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6753
ctccaacatc aaggaaga                                                    18

<210>  6754
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6754
ctccaacatc aaggaag                                                     17

<210>  6755
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  6755
tccaacatca aggaagatgg catttctag                                        29

<210>  6756
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  6756
tccaacatca aggaagatgg catttcta                                         28

<210>  6757
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  6757
tccaacatca aggaagatgg catttct                                          27

<210>  6758
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6758
tccaacatca aggaagatgg catttc                                           26

<210>  6759
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6759
tccaacatca aggaagatgg cattt                                            25

<210>  6760
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6760
tccaacatca aggaagatgg catt                                             24

<210>  6761
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6761
tccaacatca aggaagatgg cat                                              23

<210>  6762
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6762
tccaacatca aggaagatgg ca                                               22

<210>  6763
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6763
tccaacatca aggaagatgg c                                                21

<210>  6764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6764
tccaacatca aggaagatgg                                                  20

<210>  6765
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6765
tccaacatca aggaagatg                                                   19

<210>  6766
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6766
tccaacatca aggaagat                                                    18

<210>  6767
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6767
tccaacatca aggaaga                                                     17

<210>  6768
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6768
tccaacatca aggaag                                                      16

<210>  6769
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  6769
ccaacatcaa ggaagatggc atttctag                                         28

<210>  6770
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  6770
ccaacatcaa ggaagatggc atttcta                                          27

<210>  6771
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6771
ccaacatcaa ggaagatggc atttct                                           26

<210>  6772
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6772
ccaacatcaa ggaagatggc atttc                                            25

<210>  6773
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6773
ccaacatcaa ggaagatggc attt                                             24

<210>  6774
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6774
ccaacatcaa ggaagatggc att                                              23

<210>  6775
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6775
ccaacatcaa ggaagatggc at                                               22

<210>  6776
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6776
ccaacatcaa ggaagatggc a                                                21

<210>  6777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6777
ccaacatcaa ggaagatggc                                                  20

<210>  6778
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6778
ccaacatcaa ggaagatgg                                                   19

<210>  6779
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6779
ccaacatcaa ggaagatg                                                    18

<210>  6780
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6780
ccaacatcaa ggaagat                                                     17

<210>  6781
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6781
ccaacatcaa ggaaga                                                      16

<210>  6782
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6782
ccaacatcaa ggaag                                                       15

<210>  6783
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  6783
caacatcaag gaagatggca tttctag                                          27

<210>  6784
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6784
caacatcaag gaagatggca tttcta                                           26

<210>  6785
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6785
caacatcaag gaagatggca tttct                                            25

<210>  6786
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6786
caacatcaag gaagatggca tttc                                             24

<210>  6787
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6787
caacatcaag gaagatggca ttt                                              23

<210>  6788
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6788
caacatcaag gaagatggca tt                                               22

<210>  6789
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6789
caacatcaag gaagatggca t                                                21

<210>  6790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6790
caacatcaag gaagatggca                                                  20

<210>  6791
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6791
caacatcaag gaagatggc                                                   19

<210>  6792
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6792
caacatcaag gaagatgg                                                    18

<210>  6793
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6793
caacatcaag gaagatg                                                     17

<210>  6794
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6794
caacatcaag gaagat                                                      16

<210>  6795
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6795
caacatcaag gaaga                                                       15

<210>  6796
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6796
caacatcaag gaag                                                        14

<210>  6797
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  6797
aacatcaagg aagatggcat ttctag                                           26

<210>  6798
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6798
aacatcaagg aagatggcat ttcta                                            25

<210>  6799
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6799
aacatcaagg aagatggcat ttct                                             24

<210>  6800
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6800
aacatcaagg aagatggcat ttc                                              23

<210>  6801
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6801
aacatcaagg aagatggcat tt                                               22

<210>  6802
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6802
aacatcaagg aagatggcat t                                                21

<210>  6803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6803
aacatcaagg aagatggcat                                                  20

<210>  6804
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6804
aacatcaagg aagatggca                                                   19

<210>  6805
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6805
aacatcaagg aagatggc                                                    18

<210>  6806
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6806
aacatcaagg aagatgg                                                     17

<210>  6807
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6807
aacatcaagg aagatg                                                      16

<210>  6808
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6808
aacatcaagg aagat                                                       15

<210>  6809
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6809
aacatcaagg aaga                                                        14

<210>  6810
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6810
aacatcaagg aag                                                         13

<210>  6811
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  6811
acatcaagga agatggcatt tctag                                            25

<210>  6812
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6812
acatcaagga agatggcatt tcta                                             24

<210>  6813
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6813
acatcaagga agatggcatt tct                                              23

<210>  6814
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6814
acatcaagga agatggcatt tc                                               22

<210>  6815
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6815
acatcaagga agatggcatt t                                                21

<210>  6816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6816
acatcaagga agatggcatt                                                  20

<210>  6817
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6817
acatcaagga agatggcat                                                   19

<210>  6818
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6818
acatcaagga agatggca                                                    18

<210>  6819
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6819
acatcaagga agatggc                                                     17

<210>  6820
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6820
acatcaagga agatgg                                                      16

<210>  6821
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6821
acatcaagga agatg                                                       15

<210>  6822
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6822
acatcaagga agat                                                        14

<210>  6823
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6823
acatcaagga aga                                                         13

<210>  6824
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6824
acatcaagga ag                                                          12

<210>  6825
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  6825
catcaaggaa gatggcattt ctag                                             24

<210>  6826
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6826
catcaaggaa gatggcattt cta                                              23

<210>  6827
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6827
catcaaggaa gatggcattt ct                                               22

<210>  6828
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6828
catcaaggaa gatggcattt c                                                21

<210>  6829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6829
catcaaggaa gatggcattt                                                  20

<210>  6830
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6830
catcaaggaa gatggcatt                                                   19

<210>  6831
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6831
catcaaggaa gatggcat                                                    18

<210>  6832
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6832
catcaaggaa gatggca                                                     17

<210>  6833
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6833
catcaaggaa gatggc                                                      16

<210>  6834
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6834
catcaaggaa gatgg                                                       15

<210>  6835
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6835
catcaaggaa gatg                                                        14

<210>  6836
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6836
catcaaggaa gat                                                         13

<210>  6837
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6837
catcaaggaa ga                                                          12

<210>  6838
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6838
catcaaggaa g                                                           11

<210>  6839
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  6839
atcaaggaag atggcatttc tag                                              23

<210>  6840
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  6840
atcaaggaag atggcatttc ta                                               22

<210>  6841
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  6841
atcaaggaag atggcatttc t                                                21

<210>  6842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6842
atcaaggaag atggcatttc                                                  20

<210>  6843
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6843
atcaaggaag atggcattt                                                   19

<210>  6844
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6844
atcaaggaag atggcatt                                                    18

<210>  6845
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6845
atcaaggaag atggcat                                                     17

<210>  6846
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6846
atcaaggaag atggca                                                      16

<210>  6847
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6847
atcaaggaag atggc                                                       15

<210>  6848
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6848
atcaaggaag atgg                                                        14

<210>  6849
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6849
atcaaggaag atg                                                         13

<210>  6850
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6850
atcaaggaag at                                                          12

<210>  6851
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6851
atcaaggaag a                                                           11

<210>  6852
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6852
atcaaggaag                                                             10

<210>  6853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6853
ggtaagttct gtccaagc                                                    18

<210>  6854
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6854
gtaagttctg tccaagcc                                                    18

<210>  6855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6855
agtcggtaag ttctgtcc                                                    18

<210>  6856
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6856
ctgtccaagc ccggttga                                                    18

<210>  6857
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6857
taagttctgt ccaag                                                       15

<210>  6858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6858
ttctgtccaa gcccggttga                                                  20

<210>  6859
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6859
ttctgtccaa gcccggttg                                                   19

<210>  6860
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6860
ttctgtccaa gcccggtt                                                    18

<210>  6861
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6861
ttctgtccaa gcccggt                                                     17

<210>  6862
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6862
ttctgtccaa gcccgg                                                      16

<210>  6863
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6863
ttctgtccaa gcccg                                                       15

<210>  6864
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6864
ttctgtccaa gccc                                                        14

<210>  6865
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6865
ttctgtccaa gcc                                                         13

<210>  6866
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6866
ttctgtccaa gc                                                          12

<210>  6867
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6867
ttctgtccaa g                                                           11

<210>  6868
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6868
ttctgtccaa                                                             10

<210>  6869
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6869
ttctgtcca                                                              9

<210>  6870
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6870
ttctgtcc                                                               8

<210>  6871
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6871
tctgtccaag cccggttga                                                   19

<210>  6872
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6872
tctgtccaag cccggttg                                                    18

<210>  6873
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6873
tctgtccaag cccggtt                                                     17

<210>  6874
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6874
tctgtccaag cccggt                                                      16

<210>  6875
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6875
tctgtccaag cccgg                                                       15

<210>  6876
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6876
tctgtccaag cccg                                                        14

<210>  6877
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6877
tctgtccaag ccc                                                         13

<210>  6878
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6878
tctgtccaag cc                                                          12

<210>  6879
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6879
tctgtccaag c                                                           11

<210>  6880
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6880
tctgtccaag                                                             10

<210>  6881
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6881
tctgtccaa                                                              9

<210>  6882
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6882
tctgtcca                                                               8

<210>  6883
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6883
ctgtccaagc ccggttg                                                     17

<210>  6884
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6884
ctgtccaagc ccggtt                                                      16

<210>  6885
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6885
ctgtccaagc ccggt                                                       15

<210>  6886
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6886
ctgtccaagc ccgg                                                        14

<210>  6887
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6887
ctgtccaagc ccg                                                         13

<210>  6888
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6888
ctgtccaagc cc                                                          12

<210>  6889
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6889
ctgtccaagc c                                                           11

<210>  6890
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6890
ctgtccaagc                                                             10

<210>  6891
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6891
ctgtccaag                                                              9

<210>  6892
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6892
ctgtccaa                                                               8

<210>  6893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6893
gttctgtcca agcccggttg                                                  20

<210>  6894
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6894
gttctgtcca agcccggtt                                                   19

<210>  6895
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6895
gttctgtcca agcccggt                                                    18

<210>  6896
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6896
gttctgtcca agcccgg                                                     17

<210>  6897
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6897
gttctgtcca agcccg                                                      16

<210>  6898
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6898
gttctgtcca agccc                                                       15

<210>  6899
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6899
gttctgtcca agcc                                                        14

<210>  6900
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6900
gttctgtcca agc                                                         13

<210>  6901
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6901
gttctgtcca ag                                                          12

<210>  6902
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6902
gttctgtcca a                                                           11

<210>  6903
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6903
gttctgtcca                                                             10

<210>  6904
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6904
gttctgtcc                                                              9

<210>  6905
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6905
gttctgtc                                                               8

<210>  6906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6906
agttctgtcc aagcccggtt                                                  20

<210>  6907
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6907
agttctgtcc aagcccggt                                                   19

<210>  6908
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6908
agttctgtcc aagcccgg                                                    18

<210>  6909
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6909
agttctgtcc aagcccg                                                     17

<210>  6910
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6910
agttctgtcc aagccc                                                      16

<210>  6911
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6911
agttctgtcc aagcc                                                       15

<210>  6912
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6912
agttctgtcc aagc                                                        14

<210>  6913
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6913
agttctgtcc aag                                                         13

<210>  6914
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6914
agttctgtcc aa                                                          12

<210>  6915
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6915
agttctgtcc a                                                           11

<210>  6916
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6916
agttctgtcc                                                             10

<210>  6917
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6917
agttctgtc                                                              9

<210>  6918
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6918
agttctgt                                                               8

<210>  6919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6919
aagttctgtc caagcccggt                                                  20

<210>  6920
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6920
aagttctgtc caagcccgg                                                   19

<210>  6921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6921
aagttctgtc caagcccg                                                    18

<210>  6922
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6922
aagttctgtc caagccc                                                     17

<210>  6923
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6923
aagttctgtc caagcc                                                      16

<210>  6924
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6924
aagttctgtc caagc                                                       15

<210>  6925
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6925
aagttctgtc caag                                                        14

<210>  6926
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6926
aagttctgtc caa                                                         13

<210>  6927
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6927
aagttctgtc ca                                                          12

<210>  6928
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6928
aagttctgtc c                                                           11

<210>  6929
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6929
aagttctgtc                                                             10

<210>  6930
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6930
aagttctgt                                                              9

<210>  6931
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6931
aagttctg                                                               8

<210>  6932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6932
taagttctgt ccaagcccgg                                                  20

<210>  6933
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6933
taagttctgt ccaagcccg                                                   19

<210>  6934
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6934
taagttctgt ccaagccc                                                    18

<210>  6935
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6935
taagttctgt ccaagcc                                                     17

<210>  6936
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6936
taagttctgt ccaagc                                                      16

<210>  6937
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6937
taagttctgt ccaa                                                        14

<210>  6938
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6938
taagttctgt cca                                                         13

<210>  6939
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6939
taagttctgt cc                                                          12

<210>  6940
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6940
taagttctgt c                                                           11

<210>  6941
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6941
taagttctgt                                                             10

<210>  6942
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6942
taagttctg                                                              9

<210>  6943
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6943
taagttct                                                               8

<210>  6944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6944
gtaagttctg tccaagcccg                                                  20

<210>  6945
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6945
gtaagttctg tccaagccc                                                   19

<210>  6946
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6946
gtaagttctg tccaagc                                                     17

<210>  6947
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6947
gtaagttctg tccaag                                                      16

<210>  6948
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6948
gtaagttctg tccaa                                                       15

<210>  6949
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6949
gtaagttctg tcca                                                        14

<210>  6950
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6950
gtaagttctg tcc                                                         13

<210>  6951
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6951
gtaagttctg tc                                                          12

<210>  6952
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6952
gtaagttctg t                                                           11

<210>  6953
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6953
gtaagttctg                                                             10

<210>  6954
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6954
gtaagttct                                                              9

<210>  6955
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6955
gtaagttc                                                               8

<210>  6956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6956
ggtaagttct gtccaagccc                                                  20

<210>  6957
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6957
ggtaagttct gtccaagcc                                                   19

<210>  6958
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6958
ggtaagttct gtccaag                                                     17

<210>  6959
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6959
ggtaagttct gtccaa                                                      16

<210>  6960
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6960
ggtaagttct gtcca                                                       15

<210>  6961
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6961
ggtaagttct gtcc                                                        14

<210>  6962
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6962
ggtaagttct gtc                                                         13

<210>  6963
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6963
ggtaagttct gt                                                          12

<210>  6964
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6964
ggtaagttct g                                                           11

<210>  6965
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6965
ggtaagttct                                                             10

<210>  6966
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6966
ggtaagttc                                                              9

<210>  6967
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6967
ggtaagtt                                                               8

<210>  6968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6968
cggtaagttc tgtccaagcc                                                  20

<210>  6969
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6969
cggtaagttc tgtccaagc                                                   19

<210>  6970
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6970
cggtaagttc tgtccaag                                                    18

<210>  6971
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6971
cggtaagttc tgtccaa                                                     17

<210>  6972
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6972
cggtaagttc tgtcca                                                      16

<210>  6973
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6973
cggtaagttc tgtcc                                                       15

<210>  6974
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6974
cggtaagttc tgtc                                                        14

<210>  6975
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6975
cggtaagttc tgt                                                         13

<210>  6976
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6976
cggtaagttc tg                                                          12

<210>  6977
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6977
cggtaagttc t                                                           11

<210>  6978
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6978
cggtaagttc                                                             10

<210>  6979
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6979
cggtaagtt                                                              9

<210>  6980
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  6980
cggtaagt                                                               8

<210>  6981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6981
tcggtaagtt ctgtccaagc                                                  20

<210>  6982
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6982
tcggtaagtt ctgtccaag                                                   19

<210>  6983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6983
tcggtaagtt ctgtccaa                                                    18

<210>  6984
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6984
tcggtaagtt ctgtcca                                                     17

<210>  6985
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6985
tcggtaagtt ctgtcc                                                      16

<210>  6986
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6986
tcggtaagtt ctgtc                                                       15

<210>  6987
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6987
tcggtaagtt ctgt                                                        14

<210>  6988
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  6988
tcggtaagtt ctg                                                         13

<210>  6989
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  6989
tcggtaagtt ct                                                          12

<210>  6990
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  6990
tcggtaagtt c                                                           11

<210>  6991
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  6991
tcggtaagtt                                                             10

<210>  6992
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  6992
tcggtaagt                                                              9

<210>  6993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  6993
gtcggtaagt tctgtccaag                                                  20

<210>  6994
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  6994
gtcggtaagt tctgtccaa                                                   19

<210>  6995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  6995
gtcggtaagt tctgtcca                                                    18

<210>  6996
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  6996
gtcggtaagt tctgtcc                                                     17

<210>  6997
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  6997
gtcggtaagt tctgtc                                                      16

<210>  6998
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  6998
gtcggtaagt tctgt                                                       15

<210>  6999
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  6999
gtcggtaagt tctg                                                        14

<210>  7000
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7000
gtcggtaagt tct                                                         13

<210>  7001
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7001
gtcggtaagt tc                                                          12

<210>  7002
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7002
gtcggtaagt t                                                           11

<210>  7003
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7003
gtcggtaagt                                                             10

<210>  7004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7004
agtcggtaag ttctgtccaa                                                  20

<210>  7005
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7005
agtcggtaag ttctgtcca                                                   19

<210>  7006
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7006
agtcggtaag ttctgtc                                                     17

<210>  7007
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7007
agtcggtaag ttctgt                                                      16

<210>  7008
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7008
agtcggtaag ttctg                                                       15

<210>  7009
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7009
agtcggtaag ttct                                                        14

<210>  7010
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7010
agtcggtaag ttc                                                         13

<210>  7011
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7011
agtcggtaag tt                                                          12

<210>  7012
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7012
agtcggtaag t                                                           11

<210>  7013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7013
cagtcggtaa gttctgtcca                                                  20

<210>  7014
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7014
cagtcggtaa gttctgtcc                                                   19

<210>  7015
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7015
cagtcggtaa gttctgtc                                                    18

<210>  7016
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7016
cagtcggtaa gttctgt                                                     17

<210>  7017
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7017
cagtcggtaa gttctg                                                      16

<210>  7018
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7018
cagtcggtaa gttct                                                       15

<210>  7019
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7019
cagtcggtaa gttc                                                        14

<210>  7020
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7020
cagtcggtaa gtt                                                         13

<210>  7021
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7021
cagtcggtaa gt                                                          12

<210>  7022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7022
ccagtcggta agttctgtcc                                                  20

<210>  7023
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7023
ccagtcggta agttctgtc                                                   19

<210>  7024
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7024
ccagtcggta agttctgt                                                    18

<210>  7025
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7025
ccagtcggta agttctg                                                     17

<210>  7026
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7026
ccagtcggta agttct                                                      16

<210>  7027
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7027
ccagtcggta agttc                                                       15

<210>  7028
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7028
ccagtcggta agtt                                                        14

<210>  7029
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7029
ccagtcggta agt                                                         13

<210>  7030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7030
gccagtcggt aagttctgtc                                                  20

<210>  7031
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7031
gccagtcggt aagttctgt                                                   19

<210>  7032
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7032
gccagtcggt aagttctg                                                    18

<210>  7033
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7033
gccagtcggt aagttct                                                     17

<210>  7034
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7034
gccagtcggt aagttc                                                      16

<210>  7035
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7035
gccagtcggt aagtt                                                       15

<210>  7036
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7036
gccagtcggt aagt                                                        14

<210>  7037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7037
tcaaggaaga tggcatttct                                                  20

<210>  7038
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7038
tcaaggaaga tggcatttct ag                                               22

<210>  7039
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7039
tcaaggaaga tggcat                                                      16

<210>  7040
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7040
gaagatggca tttct                                                       15

<210>  7041
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7041
tcaaggaaga tggcatttct a                                                21

<210>  7042
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7042
tcaaggaaga tggcatttc                                                   19

<210>  7043
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7043
tcaaggaaga tggcattt                                                    18

<210>  7044
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7044
tcaaggaaga tggcatt                                                     17

<210>  7045
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7045
tcaaggaaga tggca                                                       15

<210>  7046
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7046
tcaaggaaga tggc                                                        14

<210>  7047
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7047
tcaaggaaga tgg                                                         13

<210>  7048
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7048
tcaaggaaga tg                                                          12

<210>  7049
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7049
tcaaggaaga t                                                           11

<210>  7050
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7050
tcaaggaaga                                                             10

<210>  7051
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7051
tcaaggaag                                                              9

<210>  7052
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7052
caaggaagat ggcatttcta g                                                21

<210>  7053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7053
caaggaagat ggcatttcta                                                  20

<210>  7054
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7054
caaggaagat ggcatttct                                                   19

<210>  7055
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7055
caaggaagat ggcatttc                                                    18

<210>  7056
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7056
caaggaagat ggcattt                                                     17

<210>  7057
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7057
caaggaagat ggcatt                                                      16

<210>  7058
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7058
caaggaagat ggcat                                                       15

<210>  7059
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7059
caaggaagat ggca                                                        14

<210>  7060
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7060
caaggaagat ggc                                                         13

<210>  7061
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7061
caaggaagat gg                                                          12

<210>  7062
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7062
caaggaagat g                                                           11

<210>  7063
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7063
caaggaagat                                                             10

<210>  7064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7064
aaggaagatg gcatttctag                                                  20

<210>  7065
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7065
aaggaagatg gcatttcta                                                   19

<210>  7066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7066
aaggaagatg gcatttct                                                    18

<210>  7067
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7067
aaggaagatg gcatttc                                                     17

<210>  7068
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7068
aaggaagatg gcattt                                                      16

<210>  7069
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7069
aaggaagatg gcatt                                                       15

<210>  7070
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7070
aaggaagatg gcat                                                        14

<210>  7071
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7071
aaggaagatg gca                                                         13

<210>  7072
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7072
aaggaagatg gc                                                          12

<210>  7073
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7073
aaggaagatg g                                                           11

<210>  7074
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7074
aaggaagatg                                                             10

<210>  7075
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7075
aaggaagat                                                              9

<210>  7076
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7076
aggaagatgg catttctag                                                   19

<210>  7077
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7077
aggaagatgg catttcta                                                    18

<210>  7078
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7078
aggaagatgg catttct                                                     17

<210>  7079
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7079
aggaagatgg catttc                                                      16

<210>  7080
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7080
aggaagatgg cattt                                                       15

<210>  7081
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7081
aggaagatgg catt                                                        14

<210>  7082
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7082
aggaagatgg cat                                                         13

<210>  7083
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7083
aggaagatgg ca                                                          12

<210>  7084
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7084
aggaagatgg                                                             10

<210>  7085
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7085
aggaagatg                                                              9

<210>  7086
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7086
aggaagat                                                               8

<210>  7087
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7087
ggaagatggc atttctag                                                    18

<210>  7088
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7088
ggaagatggc atttcta                                                     17

<210>  7089
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7089
ggaagatggc atttct                                                      16

<210>  7090
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7090
ggaagatggc atttc                                                       15

<210>  7091
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7091
ggaagatggc attt                                                        14

<210>  7092
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7092
ggaagatggc att                                                         13

<210>  7093
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7093
ggaagatggc at                                                          12

<210>  7094
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7094
ggaagatggc a                                                           11

<210>  7095
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7095
ggaagatggc                                                             10

<210>  7096
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7096
ggaagatg                                                               8

<210>  7097
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7097
gaagatggca tttctag                                                     17

<210>  7098
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7098
gaagatggca tttcta                                                      16

<210>  7099
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7099
gaagatggca tttc                                                        14

<210>  7100
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7100
gaagatggca ttt                                                         13

<210>  7101
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7101
gaagatggca tt                                                          12

<210>  7102
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7102
gaagatggca t                                                           11

<210>  7103
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7103
gaagatggca                                                             10

<210>  7104
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7104
gaagatggc                                                              9

<210>  7105
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7105
gaagatgg                                                               8

<210>  7106
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7106
aagatggcat ttctag                                                      16

<210>  7107
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7107
aagatggcat ttcta                                                       15

<210>  7108
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7108
aagatggcat ttct                                                        14

<210>  7109
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7109
aagatggcat ttc                                                         13

<210>  7110
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7110
aagatggcat tt                                                          12

<210>  7111
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7111
aagatggcat t                                                           11

<210>  7112
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7112
aagatggcat                                                             10

<210>  7113
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7113
aagatggca                                                              9

<210>  7114
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7114
aagatggc                                                               8

<210>  7115
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7115
agatggcatt tctag                                                       15

<210>  7116
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7116
agatggcatt tcta                                                        14

<210>  7117
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7117
agatggcatt tct                                                         13

<210>  7118
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7118
agatggcatt tc                                                          12

<210>  7119
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7119
agatggcatt t                                                           11

<210>  7120
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7120
agatggcatt                                                             10

<210>  7121
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7121
agatggcat                                                              9

<210>  7122
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7122
agatggca                                                               8

<210>  7123
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  7123
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  7124
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  7124
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  7125
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  7125
ctccaacatc aaggaagatg gcatttct                                         28

<210>  7126
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7126
ctccaacatc aaggaagatg gcatttc                                          27

<210>  7127
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7127
ctccaacatc aaggaagatg gcattt                                           26

<210>  7128
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7128
ctccaacatc aaggaagatg gcatt                                            25

<210>  7129
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7129
ctccaacatc aaggaagatg gcat                                             24

<210>  7130
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7130
ctccaacatc aaggaagatg gca                                              23

<210>  7131
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7131
ctccaacatc aaggaagatg gc                                               22

<210>  7132
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7132
ctccaacatc aaggaagatg g                                                21

<210>  7133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7133
ctccaacatc aaggaagatg                                                  20

<210>  7134
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7134
ctccaacatc aaggaagat                                                   19

<210>  7135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7135
ctccaacatc aaggaaga                                                    18

<210>  7136
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7136
ctccaacatc aaggaag                                                     17

<210>  7137
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  7137
tccaacatca aggaagatgg catttctag                                        29

<210>  7138
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  7138
tccaacatca aggaagatgg catttcta                                         28

<210>  7139
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7139
tccaacatca aggaagatgg catttct                                          27

<210>  7140
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7140
tccaacatca aggaagatgg catttc                                           26

<210>  7141
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7141
tccaacatca aggaagatgg cattt                                            25

<210>  7142
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7142
tccaacatca aggaagatgg catt                                             24

<210>  7143
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7143
tccaacatca aggaagatgg cat                                              23

<210>  7144
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7144
tccaacatca aggaagatgg ca                                               22

<210>  7145
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7145
tccaacatca aggaagatgg c                                                21

<210>  7146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7146
tccaacatca aggaagatgg                                                  20

<210>  7147
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7147
tccaacatca aggaagatg                                                   19

<210>  7148
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7148
tccaacatca aggaagat                                                    18

<210>  7149
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7149
tccaacatca aggaaga                                                     17

<210>  7150
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7150
tccaacatca aggaag                                                      16

<210>  7151
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  7151
ccaacatcaa ggaagatggc atttctag                                         28

<210>  7152
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7152
ccaacatcaa ggaagatggc atttcta                                          27

<210>  7153
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7153
ccaacatcaa ggaagatggc atttct                                           26

<210>  7154
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7154
ccaacatcaa ggaagatggc atttc                                            25

<210>  7155
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7155
ccaacatcaa ggaagatggc attt                                             24

<210>  7156
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7156
ccaacatcaa ggaagatggc att                                              23

<210>  7157
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7157
ccaacatcaa ggaagatggc at                                               22

<210>  7158
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7158
ccaacatcaa ggaagatggc a                                                21

<210>  7159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7159
ccaacatcaa ggaagatggc                                                  20

<210>  7160
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7160
ccaacatcaa ggaagatgg                                                   19

<210>  7161
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7161
ccaacatcaa ggaagatg                                                    18

<210>  7162
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7162
ccaacatcaa ggaagat                                                     17

<210>  7163
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7163
ccaacatcaa ggaaga                                                      16

<210>  7164
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7164
ccaacatcaa ggaag                                                       15

<210>  7165
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7165
caacatcaag gaagatggca tttctag                                          27

<210>  7166
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7166
caacatcaag gaagatggca tttcta                                           26

<210>  7167
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7167
caacatcaag gaagatggca tttct                                            25

<210>  7168
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7168
caacatcaag gaagatggca tttc                                             24

<210>  7169
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7169
caacatcaag gaagatggca ttt                                              23

<210>  7170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7170
caacatcaag gaagatggca tt                                               22

<210>  7171
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7171
caacatcaag gaagatggca t                                                21

<210>  7172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7172
caacatcaag gaagatggca                                                  20

<210>  7173
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7173
caacatcaag gaagatggc                                                   19

<210>  7174
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7174
caacatcaag gaagatgg                                                    18

<210>  7175
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7175
caacatcaag gaagatg                                                     17

<210>  7176
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7176
caacatcaag gaagat                                                      16

<210>  7177
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7177
caacatcaag gaaga                                                       15

<210>  7178
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7178
caacatcaag gaag                                                        14

<210>  7179
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7179
aacatcaagg aagatggcat ttctag                                           26

<210>  7180
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7180
aacatcaagg aagatggcat ttcta                                            25

<210>  7181
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7181
aacatcaagg aagatggcat ttct                                             24

<210>  7182
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7182
aacatcaagg aagatggcat ttc                                              23

<210>  7183
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7183
aacatcaagg aagatggcat tt                                               22

<210>  7184
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7184
aacatcaagg aagatggcat t                                                21

<210>  7185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7185
aacatcaagg aagatggcat                                                  20

<210>  7186
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7186
aacatcaagg aagatggca                                                   19

<210>  7187
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7187
aacatcaagg aagatggc                                                    18

<210>  7188
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7188
aacatcaagg aagatgg                                                     17

<210>  7189
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7189
aacatcaagg aagatg                                                      16

<210>  7190
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7190
aacatcaagg aagat                                                       15

<210>  7191
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7191
aacatcaagg aaga                                                        14

<210>  7192
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7192
aacatcaagg aag                                                         13

<210>  7193
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7193
acatcaagga agatggcatt tctag                                            25

<210>  7194
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7194
acatcaagga agatggcatt tcta                                             24

<210>  7195
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7195
acatcaagga agatggcatt tct                                              23

<210>  7196
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7196
acatcaagga agatggcatt tc                                               22

<210>  7197
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7197
acatcaagga agatggcatt t                                                21

<210>  7198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7198
acatcaagga agatggcatt                                                  20

<210>  7199
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7199
acatcaagga agatggcat                                                   19

<210>  7200
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7200
acatcaagga agatggca                                                    18

<210>  7201
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7201
acatcaagga agatggc                                                     17

<210>  7202
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7202
acatcaagga agatgg                                                      16

<210>  7203
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7203
acatcaagga agatg                                                       15

<210>  7204
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7204
acatcaagga agat                                                        14

<210>  7205
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7205
acatcaagga aga                                                         13

<210>  7206
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7206
acatcaagga ag                                                          12

<210>  7207
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7207
catcaaggaa gatggcattt ctag                                             24

<210>  7208
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7208
catcaaggaa gatggcattt cta                                              23

<210>  7209
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7209
catcaaggaa gatggcattt ct                                               22

<210>  7210
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7210
catcaaggaa gatggcattt c                                                21

<210>  7211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7211
catcaaggaa gatggcattt                                                  20

<210>  7212
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7212
catcaaggaa gatggcatt                                                   19

<210>  7213
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7213
catcaaggaa gatggcat                                                    18

<210>  7214
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7214
catcaaggaa gatggca                                                     17

<210>  7215
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7215
catcaaggaa gatggc                                                      16

<210>  7216
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7216
catcaaggaa gatgg                                                       15

<210>  7217
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7217
catcaaggaa gatg                                                        14

<210>  7218
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7218
catcaaggaa gat                                                         13

<210>  7219
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7219
catcaaggaa ga                                                          12

<210>  7220
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7220
catcaaggaa g                                                           11

<210>  7221
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7221
atcaaggaag atggcatttc tag                                              23

<210>  7222
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7222
atcaaggaag atggcatttc ta                                               22

<210>  7223
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7223
atcaaggaag atggcatttc t                                                21

<210>  7224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7224
atcaaggaag atggcatttc                                                  20

<210>  7225
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7225
atcaaggaag atggcattt                                                   19

<210>  7226
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7226
atcaaggaag atggcatt                                                    18

<210>  7227
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7227
atcaaggaag atggcat                                                     17

<210>  7228
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7228
atcaaggaag atggca                                                      16

<210>  7229
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7229
atcaaggaag atggc                                                       15

<210>  7230
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7230
atcaaggaag atgg                                                        14

<210>  7231
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7231
atcaaggaag atg                                                         13

<210>  7232
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7232
atcaaggaag at                                                          12

<210>  7233
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7233
atcaaggaag a                                                           11

<210>  7234
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7234
atcaaggaag                                                             10

<210>  7235
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7235
ggtaagttct gtccaagc                                                    18

<210>  7236
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7236
gtaagttctg tccaagcc                                                    18

<210>  7237
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7237
agtcggtaag ttctgtcc                                                    18

<210>  7238
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7238
ctgtccaagc ccggttga                                                    18

<210>  7239
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7239
taagttctgt ccaag                                                       15

<210>  7240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7240
ttctgtccaa gcccggttga                                                  20

<210>  7241
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7241
ttctgtccaa gcccggttg                                                   19

<210>  7242
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7242
ttctgtccaa gcccggtt                                                    18

<210>  7243
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7243
ttctgtccaa gcccggt                                                     17

<210>  7244
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7244
ttctgtccaa gcccgg                                                      16

<210>  7245
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7245
ttctgtccaa gcccg                                                       15

<210>  7246
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7246
ttctgtccaa gccc                                                        14

<210>  7247
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7247
ttctgtccaa gcc                                                         13

<210>  7248
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7248
ttctgtccaa gc                                                          12

<210>  7249
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7249
ttctgtccaa g                                                           11

<210>  7250
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7250
ttctgtccaa                                                             10

<210>  7251
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7251
ttctgtcca                                                              9

<210>  7252
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7252
ttctgtcc                                                               8

<210>  7253
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7253
tctgtccaag cccggttga                                                   19

<210>  7254
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7254
tctgtccaag cccggttg                                                    18

<210>  7255
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7255
tctgtccaag cccggtt                                                     17

<210>  7256
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7256
tctgtccaag cccggt                                                      16

<210>  7257
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7257
tctgtccaag cccgg                                                       15

<210>  7258
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7258
tctgtccaag cccg                                                        14

<210>  7259
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7259
tctgtccaag ccc                                                         13

<210>  7260
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7260
tctgtccaag cc                                                          12

<210>  7261
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7261
tctgtccaag c                                                           11

<210>  7262
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7262
tctgtccaag                                                             10

<210>  7263
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7263
tctgtccaa                                                              9

<210>  7264
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7264
tctgtcca                                                               8

<210>  7265
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7265
ctgtccaagc ccggttg                                                     17

<210>  7266
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7266
ctgtccaagc ccggtt                                                      16

<210>  7267
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7267
ctgtccaagc ccggt                                                       15

<210>  7268
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7268
ctgtccaagc ccgg                                                        14

<210>  7269
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7269
ctgtccaagc ccg                                                         13

<210>  7270
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7270
ctgtccaagc cc                                                          12

<210>  7271
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7271
ctgtccaagc c                                                           11

<210>  7272
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7272
ctgtccaagc                                                             10

<210>  7273
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7273
ctgtccaag                                                              9

<210>  7274
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7274
ctgtccaa                                                               8

<210>  7275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7275
gttctgtcca agcccggttg                                                  20

<210>  7276
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7276
gttctgtcca agcccggtt                                                   19

<210>  7277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7277
gttctgtcca agcccggt                                                    18

<210>  7278
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7278
gttctgtcca agcccgg                                                     17

<210>  7279
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7279
gttctgtcca agcccg                                                      16

<210>  7280
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7280
gttctgtcca agccc                                                       15

<210>  7281
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7281
gttctgtcca agcc                                                        14

<210>  7282
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7282
gttctgtcca agc                                                         13

<210>  7283
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7283
gttctgtcca ag                                                          12

<210>  7284
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7284
gttctgtcca a                                                           11

<210>  7285
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7285
gttctgtcca                                                             10

<210>  7286
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7286
gttctgtcc                                                              9

<210>  7287
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7287
gttctgtc                                                               8

<210>  7288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7288
agttctgtcc aagcccggtt                                                  20

<210>  7289
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7289
agttctgtcc aagcccggt                                                   19

<210>  7290
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7290
agttctgtcc aagcccgg                                                    18

<210>  7291
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7291
agttctgtcc aagcccg                                                     17

<210>  7292
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7292
agttctgtcc aagccc                                                      16

<210>  7293
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7293
agttctgtcc aagcc                                                       15

<210>  7294
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7294
agttctgtcc aagc                                                        14

<210>  7295
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7295
agttctgtcc aag                                                         13

<210>  7296
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7296
agttctgtcc aa                                                          12

<210>  7297
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7297
agttctgtcc a                                                           11

<210>  7298
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7298
agttctgtcc                                                             10

<210>  7299
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7299
agttctgtc                                                              9

<210>  7300
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7300
agttctgt                                                               8

<210>  7301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7301
aagttctgtc caagcccggt                                                  20

<210>  7302
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7302
aagttctgtc caagcccgg                                                   19

<210>  7303
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7303
aagttctgtc caagcccg                                                    18

<210>  7304
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7304
aagttctgtc caagccc                                                     17

<210>  7305
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7305
aagttctgtc caagcc                                                      16

<210>  7306
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7306
aagttctgtc caagc                                                       15

<210>  7307
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7307
aagttctgtc caag                                                        14

<210>  7308
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7308
aagttctgtc caa                                                         13

<210>  7309
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7309
aagttctgtc ca                                                          12

<210>  7310
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7310
aagttctgtc c                                                           11

<210>  7311
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7311
aagttctgtc                                                             10

<210>  7312
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7312
aagttctgt                                                              9

<210>  7313
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7313
aagttctg                                                               8

<210>  7314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7314
taagttctgt ccaagcccgg                                                  20

<210>  7315
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7315
taagttctgt ccaagcccg                                                   19

<210>  7316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7316
taagttctgt ccaagccc                                                    18

<210>  7317
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7317
taagttctgt ccaagcc                                                     17

<210>  7318
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7318
taagttctgt ccaagc                                                      16

<210>  7319
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7319
taagttctgt ccaa                                                        14

<210>  7320
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7320
taagttctgt cca                                                         13

<210>  7321
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7321
taagttctgt cc                                                          12

<210>  7322
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7322
taagttctgt c                                                           11

<210>  7323
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7323
taagttctgt                                                             10

<210>  7324
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7324
taagttctg                                                              9

<210>  7325
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7325
taagttct                                                               8

<210>  7326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7326
gtaagttctg tccaagcccg                                                  20

<210>  7327
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7327
gtaagttctg tccaagccc                                                   19

<210>  7328
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7328
gtaagttctg tccaagc                                                     17

<210>  7329
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7329
gtaagttctg tccaag                                                      16

<210>  7330
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7330
gtaagttctg tccaa                                                       15

<210>  7331
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7331
gtaagttctg tcca                                                        14

<210>  7332
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7332
gtaagttctg tcc                                                         13

<210>  7333
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7333
gtaagttctg tc                                                          12

<210>  7334
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7334
gtaagttctg t                                                           11

<210>  7335
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7335
gtaagttctg                                                             10

<210>  7336
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7336
gtaagttct                                                              9

<210>  7337
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7337
gtaagttc                                                               8

<210>  7338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7338
ggtaagttct gtccaagccc                                                  20

<210>  7339
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7339
ggtaagttct gtccaagcc                                                   19

<210>  7340
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7340
ggtaagttct gtccaag                                                     17

<210>  7341
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7341
ggtaagttct gtccaa                                                      16

<210>  7342
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7342
ggtaagttct gtcca                                                       15

<210>  7343
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7343
ggtaagttct gtcc                                                        14

<210>  7344
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7344
ggtaagttct gtc                                                         13

<210>  7345
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7345
ggtaagttct gt                                                          12

<210>  7346
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7346
ggtaagttct g                                                           11

<210>  7347
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7347
ggtaagttct                                                             10

<210>  7348
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7348
ggtaagttc                                                              9

<210>  7349
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7349
ggtaagtt                                                               8

<210>  7350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7350
cggtaagttc tgtccaagcc                                                  20

<210>  7351
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7351
cggtaagttc tgtccaagc                                                   19

<210>  7352
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7352
cggtaagttc tgtccaag                                                    18

<210>  7353
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7353
cggtaagttc tgtccaa                                                     17

<210>  7354
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7354
cggtaagttc tgtcca                                                      16

<210>  7355
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7355
cggtaagttc tgtcc                                                       15

<210>  7356
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7356
cggtaagttc tgtc                                                        14

<210>  7357
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7357
cggtaagttc tgt                                                         13

<210>  7358
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7358
cggtaagttc tg                                                          12

<210>  7359
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7359
cggtaagttc t                                                           11

<210>  7360
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7360
cggtaagttc                                                             10

<210>  7361
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7361
cggtaagtt                                                              9

<210>  7362
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7362
cggtaagt                                                               8

<210>  7363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7363
tcggtaagtt ctgtccaagc                                                  20

<210>  7364
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7364
tcggtaagtt ctgtccaag                                                   19

<210>  7365
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7365
tcggtaagtt ctgtccaa                                                    18

<210>  7366
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7366
tcggtaagtt ctgtcca                                                     17

<210>  7367
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7367
tcggtaagtt ctgtcc                                                      16

<210>  7368
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7368
tcggtaagtt ctgtc                                                       15

<210>  7369
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7369
tcggtaagtt ctgt                                                        14

<210>  7370
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7370
tcggtaagtt ctg                                                         13

<210>  7371
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7371
tcggtaagtt ct                                                          12

<210>  7372
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7372
tcggtaagtt c                                                           11

<210>  7373
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7373
tcggtaagtt                                                             10

<210>  7374
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7374
tcggtaagt                                                              9

<210>  7375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7375
gtcggtaagt tctgtccaag                                                  20

<210>  7376
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7376
gtcggtaagt tctgtccaa                                                   19

<210>  7377
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7377
gtcggtaagt tctgtcca                                                    18

<210>  7378
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7378
gtcggtaagt tctgtcc                                                     17

<210>  7379
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7379
gtcggtaagt tctgtc                                                      16

<210>  7380
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7380
gtcggtaagt tctgt                                                       15

<210>  7381
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7381
gtcggtaagt tctg                                                        14

<210>  7382
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7382
gtcggtaagt tct                                                         13

<210>  7383
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7383
gtcggtaagt tc                                                          12

<210>  7384
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7384
gtcggtaagt t                                                           11

<210>  7385
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7385
gtcggtaagt                                                             10

<210>  7386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7386
agtcggtaag ttctgtccaa                                                  20

<210>  7387
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7387
agtcggtaag ttctgtcca                                                   19

<210>  7388
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7388
agtcggtaag ttctgtc                                                     17

<210>  7389
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7389
agtcggtaag ttctgt                                                      16

<210>  7390
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7390
agtcggtaag ttctg                                                       15

<210>  7391
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7391
agtcggtaag ttct                                                        14

<210>  7392
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7392
agtcggtaag ttc                                                         13

<210>  7393
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7393
agtcggtaag tt                                                          12

<210>  7394
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7394
agtcggtaag t                                                           11

<210>  7395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7395
cagtcggtaa gttctgtcca                                                  20

<210>  7396
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7396
cagtcggtaa gttctgtcc                                                   19

<210>  7397
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7397
cagtcggtaa gttctgtc                                                    18

<210>  7398
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7398
cagtcggtaa gttctgt                                                     17

<210>  7399
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7399
cagtcggtaa gttctg                                                      16

<210>  7400
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7400
cagtcggtaa gttct                                                       15

<210>  7401
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7401
cagtcggtaa gttc                                                        14

<210>  7402
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7402
cagtcggtaa gtt                                                         13

<210>  7403
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7403
cagtcggtaa gt                                                          12

<210>  7404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7404
ccagtcggta agttctgtcc                                                  20

<210>  7405
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7405
ccagtcggta agttctgtc                                                   19

<210>  7406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7406
ccagtcggta agttctgt                                                    18

<210>  7407
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7407
ccagtcggta agttctg                                                     17

<210>  7408
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7408
ccagtcggta agttct                                                      16

<210>  7409
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7409
ccagtcggta agttc                                                       15

<210>  7410
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7410
ccagtcggta agtt                                                        14

<210>  7411
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7411
ccagtcggta agt                                                         13

<210>  7412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7412
gccagtcggt aagttctgtc                                                  20

<210>  7413
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7413
gccagtcggt aagttctgt                                                   19

<210>  7414
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7414
gccagtcggt aagttctg                                                    18

<210>  7415
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7415
gccagtcggt aagttct                                                     17

<210>  7416
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7416
gccagtcggt aagttc                                                      16

<210>  7417
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7417
gccagtcggt aagtt                                                       15

<210>  7418
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7418
gccagtcggt aagt                                                        14

<210>  7419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7419
tcaaggaaga tggcatttct                                                  20

<210>  7420
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7420
tcaaggaaga tggcatttct ag                                               22

<210>  7421
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7421
tcaaggaaga tggcat                                                      16

<210>  7422
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7422
gaagatggca tttct                                                       15

<210>  7423
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7423
tcaaggaaga tggcatttct a                                                21

<210>  7424
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7424
tcaaggaaga tggcatttc                                                   19

<210>  7425
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7425
tcaaggaaga tggcattt                                                    18

<210>  7426
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7426
tcaaggaaga tggcatt                                                     17

<210>  7427
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7427
tcaaggaaga tggca                                                       15

<210>  7428
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7428
tcaaggaaga tggc                                                        14

<210>  7429
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7429
tcaaggaaga tgg                                                         13

<210>  7430
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7430
tcaaggaaga tg                                                          12

<210>  7431
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7431
tcaaggaaga t                                                           11

<210>  7432
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7432
tcaaggaaga                                                             10

<210>  7433
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7433
tcaaggaag                                                              9

<210>  7434
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7434
caaggaagat ggcatttcta g                                                21

<210>  7435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7435
caaggaagat ggcatttcta                                                  20

<210>  7436
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7436
caaggaagat ggcatttct                                                   19

<210>  7437
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7437
caaggaagat ggcatttc                                                    18

<210>  7438
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7438
caaggaagat ggcattt                                                     17

<210>  7439
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7439
caaggaagat ggcatt                                                      16

<210>  7440
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7440
caaggaagat ggcat                                                       15

<210>  7441
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7441
caaggaagat ggca                                                        14

<210>  7442
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7442
caaggaagat ggc                                                         13

<210>  7443
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7443
caaggaagat gg                                                          12

<210>  7444
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7444
caaggaagat g                                                           11

<210>  7445
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7445
caaggaagat                                                             10

<210>  7446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7446
aaggaagatg gcatttctag                                                  20

<210>  7447
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7447
aaggaagatg gcatttcta                                                   19

<210>  7448
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7448
aaggaagatg gcatttct                                                    18

<210>  7449
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7449
aaggaagatg gcatttc                                                     17

<210>  7450
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7450
aaggaagatg gcattt                                                      16

<210>  7451
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7451
aaggaagatg gcatt                                                       15

<210>  7452
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7452
aaggaagatg gcat                                                        14

<210>  7453
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7453
aaggaagatg gca                                                         13

<210>  7454
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7454
aaggaagatg gc                                                          12

<210>  7455
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7455
aaggaagatg g                                                           11

<210>  7456
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7456
aaggaagatg                                                             10

<210>  7457
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7457
aaggaagat                                                              9

<210>  7458
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7458
aggaagatgg catttctag                                                   19

<210>  7459
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7459
aggaagatgg catttcta                                                    18

<210>  7460
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7460
aggaagatgg catttct                                                     17

<210>  7461
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7461
aggaagatgg catttc                                                      16

<210>  7462
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7462
aggaagatgg cattt                                                       15

<210>  7463
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7463
aggaagatgg catt                                                        14

<210>  7464
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7464
aggaagatgg cat                                                         13

<210>  7465
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7465
aggaagatgg ca                                                          12

<210>  7466
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7466
aggaagatgg                                                             10

<210>  7467
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7467
aggaagatg                                                              9

<210>  7468
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7468
aggaagat                                                               8

<210>  7469
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7469
ggaagatggc atttctag                                                    18

<210>  7470
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7470
ggaagatggc atttcta                                                     17

<210>  7471
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7471
ggaagatggc atttct                                                      16

<210>  7472
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7472
ggaagatggc atttc                                                       15

<210>  7473
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7473
ggaagatggc attt                                                        14

<210>  7474
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7474
ggaagatggc att                                                         13

<210>  7475
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7475
ggaagatggc at                                                          12

<210>  7476
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7476
ggaagatggc a                                                           11

<210>  7477
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7477
ggaagatggc                                                             10

<210>  7478
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7478
ggaagatg                                                               8

<210>  7479
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7479
gaagatggca tttctag                                                     17

<210>  7480
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7480
gaagatggca tttcta                                                      16

<210>  7481
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7481
gaagatggca tttc                                                        14

<210>  7482
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7482
gaagatggca ttt                                                         13

<210>  7483
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7483
gaagatggca tt                                                          12

<210>  7484
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7484
gaagatggca t                                                           11

<210>  7485
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7485
gaagatggca                                                             10

<210>  7486
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7486
gaagatggc                                                              9

<210>  7487
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7487
gaagatgg                                                               8

<210>  7488
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7488
aagatggcat ttctag                                                      16

<210>  7489
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7489
aagatggcat ttcta                                                       15

<210>  7490
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7490
aagatggcat ttct                                                        14

<210>  7491
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7491
aagatggcat ttc                                                         13

<210>  7492
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7492
aagatggcat tt                                                          12

<210>  7493
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7493
aagatggcat t                                                           11

<210>  7494
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7494
aagatggcat                                                             10

<210>  7495
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7495
aagatggca                                                              9

<210>  7496
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7496
aagatggc                                                               8

<210>  7497
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7497
agatggcatt tctag                                                       15

<210>  7498
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7498
agatggcatt tcta                                                        14

<210>  7499
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7499
agatggcatt tct                                                         13

<210>  7500
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7500
agatggcatt tc                                                          12

<210>  7501
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7501
agatggcatt t                                                           11

<210>  7502
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7502
agatggcatt                                                             10

<210>  7503
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7503
agatggcat                                                              9

<210>  7504
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7504
agatggca                                                               8

<210>  7505
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7505
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  7506
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7506
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  7507
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7507
ctccaacatc aaggaagatg gcatttct                                         28

<210>  7508
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7508
ctccaacatc aaggaagatg gcatttc                                          27

<210>  7509
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7509
ctccaacatc aaggaagatg gcattt                                           26

<210>  7510
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7510
ctccaacatc aaggaagatg gcatt                                            25

<210>  7511
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7511
ctccaacatc aaggaagatg gcat                                             24

<210>  7512
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7512
ctccaacatc aaggaagatg gca                                              23

<210>  7513
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7513
ctccaacatc aaggaagatg gc                                               22

<210>  7514
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7514
ctccaacatc aaggaagatg g                                                21

<210>  7515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7515
ctccaacatc aaggaagatg                                                  20

<210>  7516
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7516
ctccaacatc aaggaagat                                                   19

<210>  7517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7517
ctccaacatc aaggaaga                                                    18

<210>  7518
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7518
ctccaacatc aaggaag                                                     17

<210>  7519
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7519
tccaacatca aggaagatgg catttctag                                        29

<210>  7520
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7520
tccaacatca aggaagatgg catttcta                                         28

<210>  7521
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7521
tccaacatca aggaagatgg catttct                                          27

<210>  7522
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7522
tccaacatca aggaagatgg catttc                                           26

<210>  7523
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7523
tccaacatca aggaagatgg cattt                                            25

<210>  7524
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7524
tccaacatca aggaagatgg catt                                             24

<210>  7525
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7525
tccaacatca aggaagatgg cat                                              23

<210>  7526
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7526
tccaacatca aggaagatgg ca                                               22

<210>  7527
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7527
tccaacatca aggaagatgg c                                                21

<210>  7528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7528
tccaacatca aggaagatgg                                                  20

<210>  7529
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7529
tccaacatca aggaagatg                                                   19

<210>  7530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7530
tccaacatca aggaagat                                                    18

<210>  7531
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7531
tccaacatca aggaaga                                                     17

<210>  7532
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7532
tccaacatca aggaag                                                      16

<210>  7533
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7533
ccaacatcaa ggaagatggc atttctag                                         28

<210>  7534
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7534
ccaacatcaa ggaagatggc atttcta                                          27

<210>  7535
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7535
ccaacatcaa ggaagatggc atttct                                           26

<210>  7536
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7536
ccaacatcaa ggaagatggc atttc                                            25

<210>  7537
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7537
ccaacatcaa ggaagatggc attt                                             24

<210>  7538
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7538
ccaacatcaa ggaagatggc att                                              23

<210>  7539
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7539
ccaacatcaa ggaagatggc at                                               22

<210>  7540
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7540
ccaacatcaa ggaagatggc a                                                21

<210>  7541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7541
ccaacatcaa ggaagatggc                                                  20

<210>  7542
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7542
ccaacatcaa ggaagatgg                                                   19

<210>  7543
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7543
ccaacatcaa ggaagatg                                                    18

<210>  7544
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7544
ccaacatcaa ggaagat                                                     17

<210>  7545
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7545
ccaacatcaa ggaaga                                                      16

<210>  7546
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7546
ccaacatcaa ggaag                                                       15

<210>  7547
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7547
caacatcaag gaagatggca tttctag                                          27

<210>  7548
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7548
caacatcaag gaagatggca tttcta                                           26

<210>  7549
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7549
caacatcaag gaagatggca tttct                                            25

<210>  7550
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7550
caacatcaag gaagatggca tttc                                             24

<210>  7551
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7551
caacatcaag gaagatggca ttt                                              23

<210>  7552
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7552
caacatcaag gaagatggca tt                                               22

<210>  7553
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7553
caacatcaag gaagatggca t                                                21

<210>  7554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7554
caacatcaag gaagatggca                                                  20

<210>  7555
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7555
caacatcaag gaagatggc                                                   19

<210>  7556
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7556
caacatcaag gaagatgg                                                    18

<210>  7557
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7557
caacatcaag gaagatg                                                     17

<210>  7558
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7558
caacatcaag gaagat                                                      16

<210>  7559
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7559
caacatcaag gaaga                                                       15

<210>  7560
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7560
caacatcaag gaag                                                        14

<210>  7561
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7561
aacatcaagg aagatggcat ttctag                                           26

<210>  7562
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7562
aacatcaagg aagatggcat ttcta                                            25

<210>  7563
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7563
aacatcaagg aagatggcat ttct                                             24

<210>  7564
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7564
aacatcaagg aagatggcat ttc                                              23

<210>  7565
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7565
aacatcaagg aagatggcat tt                                               22

<210>  7566
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7566
aacatcaagg aagatggcat t                                                21

<210>  7567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7567
aacatcaagg aagatggcat                                                  20

<210>  7568
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7568
aacatcaagg aagatggca                                                   19

<210>  7569
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7569
aacatcaagg aagatggc                                                    18

<210>  7570
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7570
aacatcaagg aagatgg                                                     17

<210>  7571
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7571
aacatcaagg aagatg                                                      16

<210>  7572
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7572
aacatcaagg aagat                                                       15

<210>  7573
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7573
aacatcaagg aaga                                                        14

<210>  7574
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7574
aacatcaagg aag                                                         13

<210>  7575
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7575
acatcaagga agatggcatt tctag                                            25

<210>  7576
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7576
acatcaagga agatggcatt tcta                                             24

<210>  7577
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7577
acatcaagga agatggcatt tct                                              23

<210>  7578
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7578
acatcaagga agatggcatt tc                                               22

<210>  7579
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7579
acatcaagga agatggcatt t                                                21

<210>  7580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7580
acatcaagga agatggcatt                                                  20

<210>  7581
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7581
acatcaagga agatggcat                                                   19

<210>  7582
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7582
acatcaagga agatggca                                                    18

<210>  7583
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7583
acatcaagga agatggc                                                     17

<210>  7584
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7584
acatcaagga agatgg                                                      16

<210>  7585
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7585
acatcaagga agatg                                                       15

<210>  7586
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7586
acatcaagga agat                                                        14

<210>  7587
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7587
acatcaagga aga                                                         13

<210>  7588
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7588
acatcaagga ag                                                          12

<210>  7589
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7589
catcaaggaa gatggcattt ctag                                             24

<210>  7590
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7590
catcaaggaa gatggcattt cta                                              23

<210>  7591
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7591
catcaaggaa gatggcattt ct                                               22

<210>  7592
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7592
catcaaggaa gatggcattt c                                                21

<210>  7593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7593
catcaaggaa gatggcattt                                                  20

<210>  7594
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7594
catcaaggaa gatggcatt                                                   19

<210>  7595
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7595
catcaaggaa gatggcat                                                    18

<210>  7596
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7596
catcaaggaa gatggca                                                     17

<210>  7597
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7597
catcaaggaa gatggc                                                      16

<210>  7598
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7598
catcaaggaa gatgg                                                       15

<210>  7599
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7599
catcaaggaa gatg                                                        14

<210>  7600
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7600
catcaaggaa gat                                                         13

<210>  7601
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7601
catcaaggaa ga                                                          12

<210>  7602
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7602
catcaaggaa g                                                           11

<210>  7603
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7603
atcaaggaag atggcatttc tag                                              23

<210>  7604
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7604
atcaaggaag atggcatttc ta                                               22

<210>  7605
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7605
atcaaggaag atggcatttc t                                                21

<210>  7606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7606
atcaaggaag atggcatttc                                                  20

<210>  7607
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7607
atcaaggaag atggcattt                                                   19

<210>  7608
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7608
atcaaggaag atggcatt                                                    18

<210>  7609
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7609
atcaaggaag atggcat                                                     17

<210>  7610
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7610
atcaaggaag atggca                                                      16

<210>  7611
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7611
atcaaggaag atggc                                                       15

<210>  7612
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7612
atcaaggaag atgg                                                        14

<210>  7613
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7613
atcaaggaag atg                                                         13

<210>  7614
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7614
atcaaggaag at                                                          12

<210>  7615
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7615
atcaaggaag a                                                           11

<210>  7616
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  7616
atcaaggaag                                                             10

<210>  7617
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7617
ggtaagttct gtccaagc                                                    18

<210>  7618
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7618
gtaagttctg tccaagcc                                                    18

<210>  7619
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7619
agtcggtaag ttctgtcc                                                    18

<210>  7620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7620
ctgtccaagc ccggttga                                                    18

<210>  7621
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7621
taagttctgt ccaag                                                       15

<210>  7622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7622
ttctgtccaa gcccggttga                                                  20

<210>  7623
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7623
ttctgtccaa gcccggttg                                                   19

<210>  7624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7624
ttctgtccaa gcccggtt                                                    18

<210>  7625
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7625
ttctgtccaa gcccggt                                                     17

<210>  7626
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7626
ttctgtccaa gcccgg                                                      16

<210>  7627
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7627
ttctgtccaa gcccg                                                       15

<210>  7628
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7628
ttctgtccaa gccc                                                        14

<210>  7629
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7629
ttctgtccaa gcc                                                         13

<210>  7630
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7630
ttctgtccaa gc                                                          12

<210>  7631
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7631
ttctgtccaa g                                                           11

<210>  7632
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7632
ttctgtccaa                                                             10

<210>  7633
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7633
ttctgtcca                                                              9

<210>  7634
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7634
ttctgtcc                                                               8

<210>  7635
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7635
tctgtccaag cccggttga                                                   19

<210>  7636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7636
tctgtccaag cccggttg                                                    18

<210>  7637
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7637
tctgtccaag cccggtt                                                     17

<210>  7638
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7638
tctgtccaag cccggt                                                      16

<210>  7639
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7639
tctgtccaag cccgg                                                       15

<210>  7640
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7640
tctgtccaag cccg                                                        14

<210>  7641
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7641
tctgtccaag ccc                                                         13

<210>  7642
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7642
tctgtccaag cc                                                          12

<210>  7643
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7643
tctgtccaag c                                                           11

<210>  7644
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7644
tctgtccaag                                                             10

<210>  7645
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7645
tctgtccaa                                                              9

<210>  7646
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7646
tctgtcca                                                               8

<210>  7647
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7647
ctgtccaagc ccggttg                                                     17

<210>  7648
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7648
ctgtccaagc ccggtt                                                      16

<210>  7649
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7649
ctgtccaagc ccggt                                                       15

<210>  7650
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7650
ctgtccaagc ccgg                                                        14

<210>  7651
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7651
ctgtccaagc ccg                                                         13

<210>  7652
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7652
ctgtccaagc cc                                                          12

<210>  7653
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7653
ctgtccaagc c                                                           11

<210>  7654
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7654
ctgtccaagc                                                             10

<210>  7655
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7655
ctgtccaag                                                              9

<210>  7656
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7656
ctgtccaa                                                               8

<210>  7657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7657
gttctgtcca agcccggttg                                                  20

<210>  7658
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7658
gttctgtcca agcccggtt                                                   19

<210>  7659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7659
gttctgtcca agcccggt                                                    18

<210>  7660
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7660
gttctgtcca agcccgg                                                     17

<210>  7661
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7661
gttctgtcca agcccg                                                      16

<210>  7662
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7662
gttctgtcca agccc                                                       15

<210>  7663
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7663
gttctgtcca agcc                                                        14

<210>  7664
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7664
gttctgtcca agc                                                         13

<210>  7665
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7665
gttctgtcca ag                                                          12

<210>  7666
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7666
gttctgtcca a                                                           11

<210>  7667
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7667
gttctgtcca                                                             10

<210>  7668
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7668
gttctgtcc                                                              9

<210>  7669
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7669
gttctgtc                                                               8

<210>  7670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7670
agttctgtcc aagcccggtt                                                  20

<210>  7671
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7671
agttctgtcc aagcccggt                                                   19

<210>  7672
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7672
agttctgtcc aagcccgg                                                    18

<210>  7673
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7673
agttctgtcc aagcccg                                                     17

<210>  7674
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7674
agttctgtcc aagccc                                                      16

<210>  7675
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7675
agttctgtcc aagcc                                                       15

<210>  7676
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7676
agttctgtcc aagc                                                        14

<210>  7677
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7677
agttctgtcc aag                                                         13

<210>  7678
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7678
agttctgtcc aa                                                          12

<210>  7679
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7679
agttctgtcc a                                                           11

<210>  7680
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7680
agttctgtcc                                                             10

<210>  7681
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7681
agttctgtc                                                              9

<210>  7682
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7682
agttctgt                                                               8

<210>  7683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7683
aagttctgtc caagcccggt                                                  20

<210>  7684
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7684
aagttctgtc caagcccgg                                                   19

<210>  7685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7685
aagttctgtc caagcccg                                                    18

<210>  7686
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7686
aagttctgtc caagccc                                                     17

<210>  7687
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7687
aagttctgtc caagcc                                                      16

<210>  7688
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7688
aagttctgtc caagc                                                       15

<210>  7689
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7689
aagttctgtc caag                                                        14

<210>  7690
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7690
aagttctgtc caa                                                         13

<210>  7691
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7691
aagttctgtc ca                                                          12

<210>  7692
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7692
aagttctgtc c                                                           11

<210>  7693
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7693
aagttctgtc                                                             10

<210>  7694
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7694
aagttctgt                                                              9

<210>  7695
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7695
aagttctg                                                               8

<210>  7696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7696
taagttctgt ccaagcccgg                                                  20

<210>  7697
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7697
taagttctgt ccaagcccg                                                   19

<210>  7698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7698
taagttctgt ccaagccc                                                    18

<210>  7699
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7699
taagttctgt ccaagcc                                                     17

<210>  7700
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7700
taagttctgt ccaagc                                                      16

<210>  7701
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7701
taagttctgt ccaa                                                        14

<210>  7702
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7702
taagttctgt cca                                                         13

<210>  7703
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7703
taagttctgt cc                                                          12

<210>  7704
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7704
taagttctgt c                                                           11

<210>  7705
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7705
taagttctgt                                                             10

<210>  7706
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7706
taagttctg                                                              9

<210>  7707
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7707
taagttct                                                               8

<210>  7708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7708
gtaagttctg tccaagcccg                                                  20

<210>  7709
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7709
gtaagttctg tccaagccc                                                   19

<210>  7710
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7710
gtaagttctg tccaagc                                                     17

<210>  7711
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7711
gtaagttctg tccaag                                                      16

<210>  7712
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7712
gtaagttctg tccaa                                                       15

<210>  7713
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7713
gtaagttctg tcca                                                        14

<210>  7714
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7714
gtaagttctg tcc                                                         13

<210>  7715
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7715
gtaagttctg tc                                                          12

<210>  7716
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7716
gtaagttctg t                                                           11

<210>  7717
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7717
gtaagttctg                                                             10

<210>  7718
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7718
gtaagttct                                                              9

<210>  7719
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7719
gtaagttc                                                               8

<210>  7720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7720
ggtaagttct gtccaagccc                                                  20

<210>  7721
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7721
ggtaagttct gtccaagcc                                                   19

<210>  7722
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7722
ggtaagttct gtccaag                                                     17

<210>  7723
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7723
ggtaagttct gtccaa                                                      16

<210>  7724
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7724
ggtaagttct gtcca                                                       15

<210>  7725
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7725
ggtaagttct gtcc                                                        14

<210>  7726
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7726
ggtaagttct gtc                                                         13

<210>  7727
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7727
ggtaagttct gt                                                          12

<210>  7728
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7728
ggtaagttct g                                                           11

<210>  7729
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7729
ggtaagttct                                                             10

<210>  7730
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7730
ggtaagttc                                                              9

<210>  7731
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7731
ggtaagtt                                                               8

<210>  7732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7732
cggtaagttc tgtccaagcc                                                  20

<210>  7733
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7733
cggtaagttc tgtccaagc                                                   19

<210>  7734
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7734
cggtaagttc tgtccaag                                                    18

<210>  7735
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7735
cggtaagttc tgtccaa                                                     17

<210>  7736
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7736
cggtaagttc tgtcca                                                      16

<210>  7737
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7737
cggtaagttc tgtcc                                                       15

<210>  7738
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7738
cggtaagttc tgtc                                                        14

<210>  7739
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7739
cggtaagttc tgt                                                         13

<210>  7740
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7740
cggtaagttc tg                                                          12

<210>  7741
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7741
cggtaagttc t                                                           11

<210>  7742
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7742
cggtaagttc                                                             10

<210>  7743
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7743
cggtaagtt                                                              9

<210>  7744
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7744
cggtaagt                                                               8

<210>  7745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7745
tcggtaagtt ctgtccaagc                                                  20

<210>  7746
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7746
tcggtaagtt ctgtccaag                                                   19

<210>  7747
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7747
tcggtaagtt ctgtccaa                                                    18

<210>  7748
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7748
tcggtaagtt ctgtcca                                                     17

<210>  7749
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7749
tcggtaagtt ctgtcc                                                      16

<210>  7750
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7750
tcggtaagtt ctgtc                                                       15

<210>  7751
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7751
tcggtaagtt ctgt                                                        14

<210>  7752
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7752
tcggtaagtt ctg                                                         13

<210>  7753
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7753
tcggtaagtt ct                                                          12

<210>  7754
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7754
tcggtaagtt c                                                           11

<210>  7755
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7755
tcggtaagtt                                                             10

<210>  7756
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7756
tcggtaagt                                                              9

<210>  7757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7757
gtcggtaagt tctgtccaag                                                  20

<210>  7758
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7758
gtcggtaagt tctgtccaa                                                   19

<210>  7759
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7759
gtcggtaagt tctgtcca                                                    18

<210>  7760
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7760
gtcggtaagt tctgtcc                                                     17

<210>  7761
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7761
gtcggtaagt tctgtc                                                      16

<210>  7762
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7762
gtcggtaagt tctgt                                                       15

<210>  7763
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7763
gtcggtaagt tctg                                                        14

<210>  7764
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7764
gtcggtaagt tct                                                         13

<210>  7765
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7765
gtcggtaagt tc                                                          12

<210>  7766
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7766
gtcggtaagt t                                                           11

<210>  7767
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7767
gtcggtaagt                                                             10

<210>  7768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7768
agtcggtaag ttctgtccaa                                                  20

<210>  7769
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7769
agtcggtaag ttctgtcca                                                   19

<210>  7770
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7770
agtcggtaag ttctgtc                                                     17

<210>  7771
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7771
agtcggtaag ttctgt                                                      16

<210>  7772
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7772
agtcggtaag ttctg                                                       15

<210>  7773
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7773
agtcggtaag ttct                                                        14

<210>  7774
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7774
agtcggtaag ttc                                                         13

<210>  7775
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7775
agtcggtaag tt                                                          12

<210>  7776
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7776
agtcggtaag t                                                           11

<210>  7777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7777
cagtcggtaa gttctgtcca                                                  20

<210>  7778
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7778
cagtcggtaa gttctgtcc                                                   19

<210>  7779
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7779
cagtcggtaa gttctgtc                                                    18

<210>  7780
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7780
cagtcggtaa gttctgt                                                     17

<210>  7781
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7781
cagtcggtaa gttctg                                                      16

<210>  7782
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7782
cagtcggtaa gttct                                                       15

<210>  7783
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7783
cagtcggtaa gttc                                                        14

<210>  7784
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7784
cagtcggtaa gtt                                                         13

<210>  7785
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7785
cagtcggtaa gt                                                          12

<210>  7786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7786
ccagtcggta agttctgtcc                                                  20

<210>  7787
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7787
ccagtcggta agttctgtc                                                   19

<210>  7788
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7788
ccagtcggta agttctgt                                                    18

<210>  7789
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7789
ccagtcggta agttctg                                                     17

<210>  7790
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7790
ccagtcggta agttct                                                      16

<210>  7791
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7791
ccagtcggta agttc                                                       15

<210>  7792
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7792
ccagtcggta agtt                                                        14

<210>  7793
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7793
ccagtcggta agt                                                         13

<210>  7794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7794
gccagtcggt aagttctgtc                                                  20

<210>  7795
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7795
gccagtcggt aagttctgt                                                   19

<210>  7796
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7796
gccagtcggt aagttctg                                                    18

<210>  7797
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7797
gccagtcggt aagttct                                                     17

<210>  7798
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7798
gccagtcggt aagttc                                                      16

<210>  7799
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7799
gccagtcggt aagtt                                                       15

<210>  7800
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7800
gccagtcggt aagt                                                        14

<210>  7801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7801
tcaaggaaga tggcatttct                                                  20

<210>  7802
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7802
tcaaggaaga tggcatttct ag                                               22

<210>  7803
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7803
tcaaggaaga tggcat                                                      16

<210>  7804
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7804
gaagatggca tttct                                                       15

<210>  7805
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7805
tcaaggaaga tggcatttct a                                                21

<210>  7806
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7806
tcaaggaaga tggcatttc                                                   19

<210>  7807
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7807
tcaaggaaga tggcattt                                                    18

<210>  7808
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7808
tcaaggaaga tggcatt                                                     17

<210>  7809
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7809
tcaaggaaga tggca                                                       15

<210>  7810
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7810
tcaaggaaga tggc                                                        14

<210>  7811
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7811
tcaaggaaga tgg                                                         13

<210>  7812
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7812
tcaaggaaga tg                                                          12

<210>  7813
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7813
tcaaggaaga t                                                           11

<210>  7814
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7814
tcaaggaaga                                                             10

<210>  7815
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7815
tcaaggaag                                                              9

<210>  7816
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7816
caaggaagat ggcatttcta g                                                21

<210>  7817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7817
caaggaagat ggcatttcta                                                  20

<210>  7818
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7818
caaggaagat ggcatttct                                                   19

<210>  7819
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7819
caaggaagat ggcatttc                                                    18

<210>  7820
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7820
caaggaagat ggcattt                                                     17

<210>  7821
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7821
caaggaagat ggcatt                                                      16

<210>  7822
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7822
caaggaagat ggcat                                                       15

<210>  7823
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7823
caaggaagat ggca                                                        14

<210>  7824
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7824
caaggaagat ggc                                                         13

<210>  7825
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7825
caaggaagat gg                                                          12

<210>  7826
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7826
caaggaagat g                                                           11

<210>  7827
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7827
caaggaagat                                                             10

<210>  7828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7828
aaggaagatg gcatttctag                                                  20

<210>  7829
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7829
aaggaagatg gcatttcta                                                   19

<210>  7830
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7830
aaggaagatg gcatttct                                                    18

<210>  7831
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7831
aaggaagatg gcatttc                                                     17

<210>  7832
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7832
aaggaagatg gcattt                                                      16

<210>  7833
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7833
aaggaagatg gcatt                                                       15

<210>  7834
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7834
aaggaagatg gcat                                                        14

<210>  7835
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7835
aaggaagatg gca                                                         13

<210>  7836
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7836
aaggaagatg gc                                                          12

<210>  7837
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7837
aaggaagatg g                                                           11

<210>  7838
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7838
aaggaagatg                                                             10

<210>  7839
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7839
aaggaagat                                                              9

<210>  7840
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7840
aggaagatgg catttctag                                                   19

<210>  7841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7841
aggaagatgg catttcta                                                    18

<210>  7842
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7842
aggaagatgg catttct                                                     17

<210>  7843
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7843
aggaagatgg catttc                                                      16

<210>  7844
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7844
aggaagatgg cattt                                                       15

<210>  7845
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7845
aggaagatgg catt                                                        14

<210>  7846
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7846
aggaagatgg cat                                                         13

<210>  7847
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7847
aggaagatgg ca                                                          12

<210>  7848
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7848
aggaagatgg                                                             10

<210>  7849
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7849
aggaagatg                                                              9

<210>  7850
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7850
aggaagat                                                               8

<210>  7851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7851
ggaagatggc atttctag                                                    18

<210>  7852
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7852
ggaagatggc atttcta                                                     17

<210>  7853
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7853
ggaagatggc atttct                                                      16

<210>  7854
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7854
ggaagatggc atttc                                                       15

<210>  7855
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7855
ggaagatggc attt                                                        14

<210>  7856
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7856
ggaagatggc att                                                         13

<210>  7857
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7857
ggaagatggc at                                                          12

<210>  7858
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7858
ggaagatggc a                                                           11

<210>  7859
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7859
ggaagatggc                                                             10

<210>  7860
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7860
ggaagatg                                                               8

<210>  7861
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7861
gaagatggca tttctag                                                     17

<210>  7862
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7862
gaagatggca tttcta                                                      16

<210>  7863
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7863
gaagatggca tttc                                                        14

<210>  7864
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7864
gaagatggca ttt                                                         13

<210>  7865
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7865
gaagatggca tt                                                          12

<210>  7866
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7866
gaagatggca t                                                           11

<210>  7867
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7867
gaagatggca                                                             10

<210>  7868
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7868
gaagatggc                                                              9

<210>  7869
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7869
gaagatgg                                                               8

<210>  7870
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7870
aagatggcat ttctag                                                      16

<210>  7871
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7871
aagatggcat ttcta                                                       15

<210>  7872
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7872
aagatggcat ttct                                                        14

<210>  7873
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7873
aagatggcat ttc                                                         13

<210>  7874
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7874
aagatggcat tt                                                          12

<210>  7875
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7875
aagatggcat t                                                           11

<210>  7876
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7876
aagatggcat                                                             10

<210>  7877
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7877
aagatggca                                                              9

<210>  7878
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7878
aagatggc                                                               8

<210>  7879
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7879
agatggcatt tctag                                                       15

<210>  7880
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7880
agatggcatt tcta                                                        14

<210>  7881
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7881
agatggcatt tct                                                         13

<210>  7882
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7882
agatggcatt tc                                                          12

<210>  7883
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7883
agatggcatt t                                                           11

<210>  7884
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7884
agatggcatt                                                             10

<210>  7885
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  7885
agatggcat                                                              9

<210>  7886
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  7886
agatggca                                                               8

<210>  7887
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  7887
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  7888
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  7888
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  7889
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  7889
ctccaacatc aaggaagatg gcatttct                                         28

<210>  7890
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7890
ctccaacatc aaggaagatg gcatttc                                          27

<210>  7891
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7891
ctccaacatc aaggaagatg gcattt                                           26

<210>  7892
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7892
ctccaacatc aaggaagatg gcatt                                            25

<210>  7893
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7893
ctccaacatc aaggaagatg gcat                                             24

<210>  7894
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7894
ctccaacatc aaggaagatg gca                                              23

<210>  7895
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7895
ctccaacatc aaggaagatg gc                                               22

<210>  7896
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7896
ctccaacatc aaggaagatg g                                                21

<210>  7897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7897
ctccaacatc aaggaagatg                                                  20

<210>  7898
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7898
ctccaacatc aaggaagat                                                   19

<210>  7899
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7899
ctccaacatc aaggaaga                                                    18

<210>  7900
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7900
ctccaacatc aaggaag                                                     17

<210>  7901
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  7901
tccaacatca aggaagatgg catttctag                                        29

<210>  7902
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  7902
tccaacatca aggaagatgg catttcta                                         28

<210>  7903
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7903
tccaacatca aggaagatgg catttct                                          27

<210>  7904
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7904
tccaacatca aggaagatgg catttc                                           26

<210>  7905
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7905
tccaacatca aggaagatgg cattt                                            25

<210>  7906
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7906
tccaacatca aggaagatgg catt                                             24

<210>  7907
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7907
tccaacatca aggaagatgg cat                                              23

<210>  7908
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7908
tccaacatca aggaagatgg ca                                               22

<210>  7909
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7909
tccaacatca aggaagatgg c                                                21

<210>  7910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7910
tccaacatca aggaagatgg                                                  20

<210>  7911
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7911
tccaacatca aggaagatg                                                   19

<210>  7912
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7912
tccaacatca aggaagat                                                    18

<210>  7913
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7913
tccaacatca aggaaga                                                     17

<210>  7914
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7914
tccaacatca aggaag                                                      16

<210>  7915
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  7915
ccaacatcaa ggaagatggc atttctag                                         28

<210>  7916
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7916
ccaacatcaa ggaagatggc atttcta                                          27

<210>  7917
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7917
ccaacatcaa ggaagatggc atttct                                           26

<210>  7918
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7918
ccaacatcaa ggaagatggc atttc                                            25

<210>  7919
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7919
ccaacatcaa ggaagatggc attt                                             24

<210>  7920
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7920
ccaacatcaa ggaagatggc att                                              23

<210>  7921
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7921
ccaacatcaa ggaagatggc at                                               22

<210>  7922
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7922
ccaacatcaa ggaagatggc a                                                21

<210>  7923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7923
ccaacatcaa ggaagatggc                                                  20

<210>  7924
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7924
ccaacatcaa ggaagatgg                                                   19

<210>  7925
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7925
ccaacatcaa ggaagatg                                                    18

<210>  7926
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7926
ccaacatcaa ggaagat                                                     17

<210>  7927
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7927
ccaacatcaa ggaaga                                                      16

<210>  7928
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7928
ccaacatcaa ggaag                                                       15

<210>  7929
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  7929
caacatcaag gaagatggca tttctag                                          27

<210>  7930
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7930
caacatcaag gaagatggca tttcta                                           26

<210>  7931
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7931
caacatcaag gaagatggca tttct                                            25

<210>  7932
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7932
caacatcaag gaagatggca tttc                                             24

<210>  7933
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7933
caacatcaag gaagatggca ttt                                              23

<210>  7934
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7934
caacatcaag gaagatggca tt                                               22

<210>  7935
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7935
caacatcaag gaagatggca t                                                21

<210>  7936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7936
caacatcaag gaagatggca                                                  20

<210>  7937
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7937
caacatcaag gaagatggc                                                   19

<210>  7938
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7938
caacatcaag gaagatgg                                                    18

<210>  7939
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7939
caacatcaag gaagatg                                                     17

<210>  7940
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7940
caacatcaag gaagat                                                      16

<210>  7941
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7941
caacatcaag gaaga                                                       15

<210>  7942
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7942
caacatcaag gaag                                                        14

<210>  7943
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  7943
aacatcaagg aagatggcat ttctag                                           26

<210>  7944
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7944
aacatcaagg aagatggcat ttcta                                            25

<210>  7945
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7945
aacatcaagg aagatggcat ttct                                             24

<210>  7946
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7946
aacatcaagg aagatggcat ttc                                              23

<210>  7947
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7947
aacatcaagg aagatggcat tt                                               22

<210>  7948
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7948
aacatcaagg aagatggcat t                                                21

<210>  7949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7949
aacatcaagg aagatggcat                                                  20

<210>  7950
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7950
aacatcaagg aagatggca                                                   19

<210>  7951
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7951
aacatcaagg aagatggc                                                    18

<210>  7952
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7952
aacatcaagg aagatgg                                                     17

<210>  7953
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7953
aacatcaagg aagatg                                                      16

<210>  7954
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7954
aacatcaagg aagat                                                       15

<210>  7955
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7955
aacatcaagg aaga                                                        14

<210>  7956
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7956
aacatcaagg aag                                                         13

<210>  7957
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  7957
acatcaagga agatggcatt tctag                                            25

<210>  7958
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7958
acatcaagga agatggcatt tcta                                             24

<210>  7959
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7959
acatcaagga agatggcatt tct                                              23

<210>  7960
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7960
acatcaagga agatggcatt tc                                               22

<210>  7961
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7961
acatcaagga agatggcatt t                                                21

<210>  7962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7962
acatcaagga agatggcatt                                                  20

<210>  7963
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7963
acatcaagga agatggcat                                                   19

<210>  7964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7964
acatcaagga agatggca                                                    18

<210>  7965
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7965
acatcaagga agatggc                                                     17

<210>  7966
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7966
acatcaagga agatgg                                                      16

<210>  7967
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7967
acatcaagga agatg                                                       15

<210>  7968
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7968
acatcaagga agat                                                        14

<210>  7969
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7969
acatcaagga aga                                                         13

<210>  7970
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7970
acatcaagga ag                                                          12

<210>  7971
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  7971
catcaaggaa gatggcattt ctag                                             24

<210>  7972
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7972
catcaaggaa gatggcattt cta                                              23

<210>  7973
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7973
catcaaggaa gatggcattt ct                                               22

<210>  7974
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7974
catcaaggaa gatggcattt c                                                21

<210>  7975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7975
catcaaggaa gatggcattt                                                  20

<210>  7976
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7976
catcaaggaa gatggcatt                                                   19

<210>  7977
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7977
catcaaggaa gatggcat                                                    18

<210>  7978
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7978
catcaaggaa gatggca                                                     17

<210>  7979
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7979
catcaaggaa gatggc                                                      16

<210>  7980
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7980
catcaaggaa gatgg                                                       15

<210>  7981
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7981
catcaaggaa gatg                                                        14

<210>  7982
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7982
catcaaggaa gat                                                         13

<210>  7983
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7983
catcaaggaa ga                                                          12

<210>  7984
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7984
catcaaggaa g                                                           11

<210>  7985
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  7985
atcaaggaag atggcatttc tag                                              23

<210>  7986
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  7986
atcaaggaag atggcatttc ta                                               22

<210>  7987
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  7987
atcaaggaag atggcatttc t                                                21

<210>  7988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  7988
atcaaggaag atggcatttc                                                  20

<210>  7989
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  7989
atcaaggaag atggcattt                                                   19

<210>  7990
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7990
atcaaggaag atggcatt                                                    18

<210>  7991
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  7991
atcaaggaag atggcat                                                     17

<210>  7992
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  7992
atcaaggaag atggca                                                      16

<210>  7993
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  7993
atcaaggaag atggc                                                       15

<210>  7994
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  7994
atcaaggaag atgg                                                        14

<210>  7995
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  7995
atcaaggaag atg                                                         13

<210>  7996
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  7996
atcaaggaag at                                                          12

<210>  7997
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  7997
atcaaggaag a                                                           11

<210>  7998
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  7998
atcaaggaag                                                             10

<210>  7999
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  7999
ggtaagttct gtccaagc                                                    18

<210>  8000
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8000
gtaagttctg tccaagcc                                                    18

<210>  8001
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8001
agtcggtaag ttctgtcc                                                    18

<210>  8002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8002
ctgtccaagc ccggttga                                                    18

<210>  8003
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8003
taagttctgt ccaag                                                       15

<210>  8004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8004
ttctgtccaa gcccggttga                                                  20

<210>  8005
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8005
ttctgtccaa gcccggttg                                                   19

<210>  8006
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8006
ttctgtccaa gcccggtt                                                    18

<210>  8007
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8007
ttctgtccaa gcccggt                                                     17

<210>  8008
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8008
ttctgtccaa gcccgg                                                      16

<210>  8009
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8009
ttctgtccaa gcccg                                                       15

<210>  8010
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8010
ttctgtccaa gccc                                                        14

<210>  8011
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8011
ttctgtccaa gcc                                                         13

<210>  8012
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8012
ttctgtccaa gc                                                          12

<210>  8013
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8013
ttctgtccaa g                                                           11

<210>  8014
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8014
ttctgtccaa                                                             10

<210>  8015
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8015
ttctgtcca                                                              9

<210>  8016
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8016
ttctgtcc                                                               8

<210>  8017
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8017
tctgtccaag cccggttga                                                   19

<210>  8018
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8018
tctgtccaag cccggttg                                                    18

<210>  8019
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8019
tctgtccaag cccggtt                                                     17

<210>  8020
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8020
tctgtccaag cccggt                                                      16

<210>  8021
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8021
tctgtccaag cccgg                                                       15

<210>  8022
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8022
tctgtccaag cccg                                                        14

<210>  8023
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8023
tctgtccaag ccc                                                         13

<210>  8024
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8024
tctgtccaag cc                                                          12

<210>  8025
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8025
tctgtccaag c                                                           11

<210>  8026
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8026
tctgtccaag                                                             10

<210>  8027
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8027
tctgtccaa                                                              9

<210>  8028
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8028
tctgtcca                                                               8

<210>  8029
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8029
ctgtccaagc ccggttg                                                     17

<210>  8030
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8030
ctgtccaagc ccggtt                                                      16

<210>  8031
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8031
ctgtccaagc ccggt                                                       15

<210>  8032
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8032
ctgtccaagc ccgg                                                        14

<210>  8033
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8033
ctgtccaagc ccg                                                         13

<210>  8034
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8034
ctgtccaagc cc                                                          12

<210>  8035
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8035
ctgtccaagc c                                                           11

<210>  8036
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8036
ctgtccaagc                                                             10

<210>  8037
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8037
ctgtccaag                                                              9

<210>  8038
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8038
ctgtccaa                                                               8

<210>  8039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8039
gttctgtcca agcccggttg                                                  20

<210>  8040
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8040
gttctgtcca agcccggtt                                                   19

<210>  8041
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8041
gttctgtcca agcccggt                                                    18

<210>  8042
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8042
gttctgtcca agcccgg                                                     17

<210>  8043
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8043
gttctgtcca agcccg                                                      16

<210>  8044
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8044
gttctgtcca agccc                                                       15

<210>  8045
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8045
gttctgtcca agcc                                                        14

<210>  8046
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8046
gttctgtcca agc                                                         13

<210>  8047
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8047
gttctgtcca ag                                                          12

<210>  8048
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8048
gttctgtcca a                                                           11

<210>  8049
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8049
gttctgtcca                                                             10

<210>  8050
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8050
gttctgtcc                                                              9

<210>  8051
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8051
gttctgtc                                                               8

<210>  8052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8052
agttctgtcc aagcccggtt                                                  20

<210>  8053
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8053
agttctgtcc aagcccggt                                                   19

<210>  8054
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8054
agttctgtcc aagcccgg                                                    18

<210>  8055
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8055
agttctgtcc aagcccg                                                     17

<210>  8056
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8056
agttctgtcc aagccc                                                      16

<210>  8057
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8057
agttctgtcc aagcc                                                       15

<210>  8058
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8058
agttctgtcc aagc                                                        14

<210>  8059
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8059
agttctgtcc aag                                                         13

<210>  8060
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8060
agttctgtcc aa                                                          12

<210>  8061
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8061
agttctgtcc a                                                           11

<210>  8062
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8062
agttctgtcc                                                             10

<210>  8063
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8063
agttctgtc                                                              9

<210>  8064
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8064
agttctgt                                                               8

<210>  8065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8065
aagttctgtc caagcccggt                                                  20

<210>  8066
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8066
aagttctgtc caagcccgg                                                   19

<210>  8067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8067
aagttctgtc caagcccg                                                    18

<210>  8068
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8068
aagttctgtc caagccc                                                     17

<210>  8069
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8069
aagttctgtc caagcc                                                      16

<210>  8070
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8070
aagttctgtc caagc                                                       15

<210>  8071
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8071
aagttctgtc caag                                                        14

<210>  8072
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8072
aagttctgtc caa                                                         13

<210>  8073
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8073
aagttctgtc ca                                                          12

<210>  8074
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8074
aagttctgtc c                                                           11

<210>  8075
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8075
aagttctgtc                                                             10

<210>  8076
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8076
aagttctgt                                                              9

<210>  8077
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8077
aagttctg                                                               8

<210>  8078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8078
taagttctgt ccaagcccgg                                                  20

<210>  8079
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8079
taagttctgt ccaagcccg                                                   19

<210>  8080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8080
taagttctgt ccaagccc                                                    18

<210>  8081
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8081
taagttctgt ccaagcc                                                     17

<210>  8082
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8082
taagttctgt ccaagc                                                      16

<210>  8083
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8083
taagttctgt ccaa                                                        14

<210>  8084
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8084
taagttctgt cca                                                         13

<210>  8085
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8085
taagttctgt cc                                                          12

<210>  8086
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8086
taagttctgt c                                                           11

<210>  8087
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8087
taagttctgt                                                             10

<210>  8088
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8088
taagttctg                                                              9

<210>  8089
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8089
taagttct                                                               8

<210>  8090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8090
gtaagttctg tccaagcccg                                                  20

<210>  8091
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8091
gtaagttctg tccaagccc                                                   19

<210>  8092
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8092
gtaagttctg tccaagc                                                     17

<210>  8093
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8093
gtaagttctg tccaag                                                      16

<210>  8094
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8094
gtaagttctg tccaa                                                       15

<210>  8095
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8095
gtaagttctg tcca                                                        14

<210>  8096
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8096
gtaagttctg tcc                                                         13

<210>  8097
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8097
gtaagttctg tc                                                          12

<210>  8098
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8098
gtaagttctg t                                                           11

<210>  8099
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8099
gtaagttctg                                                             10

<210>  8100
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8100
gtaagttct                                                              9

<210>  8101
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8101
gtaagttc                                                               8

<210>  8102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8102
ggtaagttct gtccaagccc                                                  20

<210>  8103
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8103
ggtaagttct gtccaagcc                                                   19

<210>  8104
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8104
ggtaagttct gtccaag                                                     17

<210>  8105
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8105
ggtaagttct gtccaa                                                      16

<210>  8106
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8106
ggtaagttct gtcca                                                       15

<210>  8107
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8107
ggtaagttct gtcc                                                        14

<210>  8108
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8108
ggtaagttct gtc                                                         13

<210>  8109
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8109
ggtaagttct gt                                                          12

<210>  8110
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8110
ggtaagttct g                                                           11

<210>  8111
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8111
ggtaagttct                                                             10

<210>  8112
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8112
ggtaagttc                                                              9

<210>  8113
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8113
ggtaagtt                                                               8

<210>  8114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8114
cggtaagttc tgtccaagcc                                                  20

<210>  8115
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8115
cggtaagttc tgtccaagc                                                   19

<210>  8116
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8116
cggtaagttc tgtccaag                                                    18

<210>  8117
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8117
cggtaagttc tgtccaa                                                     17

<210>  8118
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8118
cggtaagttc tgtcca                                                      16

<210>  8119
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8119
cggtaagttc tgtcc                                                       15

<210>  8120
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8120
cggtaagttc tgtc                                                        14

<210>  8121
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8121
cggtaagttc tgt                                                         13

<210>  8122
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8122
cggtaagttc tg                                                          12

<210>  8123
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8123
cggtaagttc t                                                           11

<210>  8124
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8124
cggtaagttc                                                             10

<210>  8125
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8125
cggtaagtt                                                              9

<210>  8126
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8126
cggtaagt                                                               8

<210>  8127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8127
tcggtaagtt ctgtccaagc                                                  20

<210>  8128
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8128
tcggtaagtt ctgtccaag                                                   19

<210>  8129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8129
tcggtaagtt ctgtccaa                                                    18

<210>  8130
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8130
tcggtaagtt ctgtcca                                                     17

<210>  8131
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8131
tcggtaagtt ctgtcc                                                      16

<210>  8132
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8132
tcggtaagtt ctgtc                                                       15

<210>  8133
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8133
tcggtaagtt ctgt                                                        14

<210>  8134
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8134
tcggtaagtt ctg                                                         13

<210>  8135
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8135
tcggtaagtt ct                                                          12

<210>  8136
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8136
tcggtaagtt c                                                           11

<210>  8137
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8137
tcggtaagtt                                                             10

<210>  8138
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8138
tcggtaagt                                                              9

<210>  8139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8139
gtcggtaagt tctgtccaag                                                  20

<210>  8140
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8140
gtcggtaagt tctgtccaa                                                   19

<210>  8141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8141
gtcggtaagt tctgtcca                                                    18

<210>  8142
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8142
gtcggtaagt tctgtcc                                                     17

<210>  8143
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8143
gtcggtaagt tctgtc                                                      16

<210>  8144
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8144
gtcggtaagt tctgt                                                       15

<210>  8145
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8145
gtcggtaagt tctg                                                        14

<210>  8146
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8146
gtcggtaagt tct                                                         13

<210>  8147
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8147
gtcggtaagt tc                                                          12

<210>  8148
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8148
gtcggtaagt t                                                           11

<210>  8149
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8149
gtcggtaagt                                                             10

<210>  8150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8150
agtcggtaag ttctgtccaa                                                  20

<210>  8151
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8151
agtcggtaag ttctgtcca                                                   19

<210>  8152
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8152
agtcggtaag ttctgtc                                                     17

<210>  8153
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8153
agtcggtaag ttctgt                                                      16

<210>  8154
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8154
agtcggtaag ttctg                                                       15

<210>  8155
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8155
agtcggtaag ttct                                                        14

<210>  8156
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8156
agtcggtaag ttc                                                         13

<210>  8157
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8157
agtcggtaag tt                                                          12

<210>  8158
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8158
agtcggtaag t                                                           11

<210>  8159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8159
cagtcggtaa gttctgtcca                                                  20

<210>  8160
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8160
cagtcggtaa gttctgtcc                                                   19

<210>  8161
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8161
cagtcggtaa gttctgtc                                                    18

<210>  8162
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8162
cagtcggtaa gttctgt                                                     17

<210>  8163
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8163
cagtcggtaa gttctg                                                      16

<210>  8164
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8164
cagtcggtaa gttct                                                       15

<210>  8165
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8165
cagtcggtaa gttc                                                        14

<210>  8166
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8166
cagtcggtaa gtt                                                         13

<210>  8167
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8167
cagtcggtaa gt                                                          12

<210>  8168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8168
ccagtcggta agttctgtcc                                                  20

<210>  8169
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8169
ccagtcggta agttctgtc                                                   19

<210>  8170
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8170
ccagtcggta agttctgt                                                    18

<210>  8171
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8171
ccagtcggta agttctg                                                     17

<210>  8172
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8172
ccagtcggta agttct                                                      16

<210>  8173
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8173
ccagtcggta agttc                                                       15

<210>  8174
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8174
ccagtcggta agtt                                                        14

<210>  8175
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8175
ccagtcggta agt                                                         13

<210>  8176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8176
gccagtcggt aagttctgtc                                                  20

<210>  8177
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8177
gccagtcggt aagttctgt                                                   19

<210>  8178
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8178
gccagtcggt aagttctg                                                    18

<210>  8179
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8179
gccagtcggt aagttct                                                     17

<210>  8180
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8180
gccagtcggt aagttc                                                      16

<210>  8181
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8181
gccagtcggt aagtt                                                       15

<210>  8182
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8182
gccagtcggt aagt                                                        14

<210>  8183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8183
tcaaggaaga tggcatttct                                                  20

<210>  8184
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8184
tcaaggaaga tggcatttct ag                                               22

<210>  8185
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8185
tcaaggaaga tggcat                                                      16

<210>  8186
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8186
gaagatggca tttct                                                       15

<210>  8187
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8187
tcaaggaaga tggcatttct a                                                21

<210>  8188
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8188
tcaaggaaga tggcatttc                                                   19

<210>  8189
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8189
tcaaggaaga tggcattt                                                    18

<210>  8190
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8190
tcaaggaaga tggcatt                                                     17

<210>  8191
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8191
tcaaggaaga tggca                                                       15

<210>  8192
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8192
tcaaggaaga tggc                                                        14

<210>  8193
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8193
tcaaggaaga tgg                                                         13

<210>  8194
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8194
tcaaggaaga tg                                                          12

<210>  8195
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8195
tcaaggaaga t                                                           11

<210>  8196
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8196
tcaaggaaga                                                             10

<210>  8197
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8197
tcaaggaag                                                              9

<210>  8198
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8198
caaggaagat ggcatttcta g                                                21

<210>  8199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8199
caaggaagat ggcatttcta                                                  20

<210>  8200
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8200
caaggaagat ggcatttct                                                   19

<210>  8201
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8201
caaggaagat ggcatttc                                                    18

<210>  8202
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8202
caaggaagat ggcattt                                                     17

<210>  8203
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8203
caaggaagat ggcatt                                                      16

<210>  8204
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8204
caaggaagat ggcat                                                       15

<210>  8205
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8205
caaggaagat ggca                                                        14

<210>  8206
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8206
caaggaagat ggc                                                         13

<210>  8207
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8207
caaggaagat gg                                                          12

<210>  8208
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8208
caaggaagat g                                                           11

<210>  8209
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8209
caaggaagat                                                             10

<210>  8210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8210
aaggaagatg gcatttctag                                                  20

<210>  8211
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8211
aaggaagatg gcatttcta                                                   19

<210>  8212
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8212
aaggaagatg gcatttct                                                    18

<210>  8213
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8213
aaggaagatg gcatttc                                                     17

<210>  8214
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8214
aaggaagatg gcattt                                                      16

<210>  8215
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8215
aaggaagatg gcatt                                                       15

<210>  8216
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8216
aaggaagatg gcat                                                        14

<210>  8217
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8217
aaggaagatg gca                                                         13

<210>  8218
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8218
aaggaagatg gc                                                          12

<210>  8219
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8219
aaggaagatg g                                                           11

<210>  8220
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8220
aaggaagatg                                                             10

<210>  8221
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8221
aaggaagat                                                              9

<210>  8222
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8222
aggaagatgg catttctag                                                   19

<210>  8223
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8223
aggaagatgg catttcta                                                    18

<210>  8224
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8224
aggaagatgg catttct                                                     17

<210>  8225
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8225
aggaagatgg catttc                                                      16

<210>  8226
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8226
aggaagatgg cattt                                                       15

<210>  8227
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8227
aggaagatgg catt                                                        14

<210>  8228
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8228
aggaagatgg cat                                                         13

<210>  8229
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8229
aggaagatgg ca                                                          12

<210>  8230
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8230
aggaagatgg                                                             10

<210>  8231
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8231
aggaagatg                                                              9

<210>  8232
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8232
aggaagat                                                               8

<210>  8233
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8233
ggaagatggc atttctag                                                    18

<210>  8234
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8234
ggaagatggc atttcta                                                     17

<210>  8235
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8235
ggaagatggc atttct                                                      16

<210>  8236
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8236
ggaagatggc atttc                                                       15

<210>  8237
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8237
ggaagatggc attt                                                        14

<210>  8238
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8238
ggaagatggc att                                                         13

<210>  8239
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8239
ggaagatggc at                                                          12

<210>  8240
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8240
ggaagatggc a                                                           11

<210>  8241
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8241
ggaagatggc                                                             10

<210>  8242
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8242
ggaagatg                                                               8

<210>  8243
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8243
gaagatggca tttctag                                                     17

<210>  8244
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8244
gaagatggca tttcta                                                      16

<210>  8245
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8245
gaagatggca tttc                                                        14

<210>  8246
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8246
gaagatggca ttt                                                         13

<210>  8247
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8247
gaagatggca tt                                                          12

<210>  8248
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8248
gaagatggca t                                                           11

<210>  8249
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8249
gaagatggca                                                             10

<210>  8250
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8250
gaagatggc                                                              9

<210>  8251
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8251
gaagatgg                                                               8

<210>  8252
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8252
aagatggcat ttctag                                                      16

<210>  8253
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8253
aagatggcat ttcta                                                       15

<210>  8254
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8254
aagatggcat ttct                                                        14

<210>  8255
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8255
aagatggcat ttc                                                         13

<210>  8256
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8256
aagatggcat tt                                                          12

<210>  8257
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8257
aagatggcat t                                                           11

<210>  8258
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8258
aagatggcat                                                             10

<210>  8259
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8259
aagatggca                                                              9

<210>  8260
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8260
aagatggc                                                               8

<210>  8261
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8261
agatggcatt tctag                                                       15

<210>  8262
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8262
agatggcatt tcta                                                        14

<210>  8263
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8263
agatggcatt tct                                                         13

<210>  8264
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8264
agatggcatt tc                                                          12

<210>  8265
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8265
agatggcatt t                                                           11

<210>  8266
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8266
agatggcatt                                                             10

<210>  8267
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8267
agatggcat                                                              9

<210>  8268
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8268
agatggca                                                               8

<210>  8269
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  8269
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  8270
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  8270
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  8271
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  8271
ctccaacatc aaggaagatg gcatttct                                         28

<210>  8272
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  8272
ctccaacatc aaggaagatg gcatttc                                          27

<210>  8273
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  8273
ctccaacatc aaggaagatg gcattt                                           26

<210>  8274
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  8274
ctccaacatc aaggaagatg gcatt                                            25

<210>  8275
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8275
ctccaacatc aaggaagatg gcat                                             24

<210>  8276
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8276
ctccaacatc aaggaagatg gca                                              23

<210>  8277
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8277
ctccaacatc aaggaagatg gc                                               22

<210>  8278
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8278
ctccaacatc aaggaagatg g                                                21

<210>  8279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8279
ctccaacatc aaggaagatg                                                  20

<210>  8280
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8280
ctccaacatc aaggaagat                                                   19

<210>  8281
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8281
ctccaacatc aaggaaga                                                    18

<210>  8282
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8282
ctccaacatc aaggaag                                                     17

<210>  8283
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  8283
tccaacatca aggaagatgg catttctag                                        29

<210>  8284
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  8284
tccaacatca aggaagatgg catttcta                                         28

<210>  8285
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  8285
tccaacatca aggaagatgg catttct                                          27

<210>  8286
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  8286
tccaacatca aggaagatgg catttc                                           26

<210>  8287
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  8287
tccaacatca aggaagatgg cattt                                            25

<210>  8288
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8288
tccaacatca aggaagatgg catt                                             24

<210>  8289
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8289
tccaacatca aggaagatgg cat                                              23

<210>  8290
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8290
tccaacatca aggaagatgg ca                                               22

<210>  8291
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8291
tccaacatca aggaagatgg c                                                21

<210>  8292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8292
tccaacatca aggaagatgg                                                  20

<210>  8293
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8293
tccaacatca aggaagatg                                                   19

<210>  8294
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8294
tccaacatca aggaagat                                                    18

<210>  8295
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8295
tccaacatca aggaaga                                                     17

<210>  8296
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8296
tccaacatca aggaag                                                      16

<210>  8297
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  8297
ccaacatcaa ggaagatggc atttctag                                         28

<210>  8298
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  8298
ccaacatcaa ggaagatggc atttcta                                          27

<210>  8299
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  8299
ccaacatcaa ggaagatggc atttct                                           26

<210>  8300
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  8300
ccaacatcaa ggaagatggc atttc                                            25

<210>  8301
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8301
ccaacatcaa ggaagatggc attt                                             24

<210>  8302
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8302
ccaacatcaa ggaagatggc att                                              23

<210>  8303
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8303
ccaacatcaa ggaagatggc at                                               22

<210>  8304
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8304
ccaacatcaa ggaagatggc a                                                21

<210>  8305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8305
ccaacatcaa ggaagatggc                                                  20

<210>  8306
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8306
ccaacatcaa ggaagatgg                                                   19

<210>  8307
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8307
ccaacatcaa ggaagatg                                                    18

<210>  8308
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8308
ccaacatcaa ggaagat                                                     17

<210>  8309
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8309
ccaacatcaa ggaaga                                                      16

<210>  8310
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8310
ccaacatcaa ggaag                                                       15

<210>  8311
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  8311
caacatcaag gaagatggca tttctag                                          27

<210>  8312
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  8312
caacatcaag gaagatggca tttcta                                           26

<210>  8313
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  8313
caacatcaag gaagatggca tttct                                            25

<210>  8314
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8314
caacatcaag gaagatggca tttc                                             24

<210>  8315
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8315
caacatcaag gaagatggca ttt                                              23

<210>  8316
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8316
caacatcaag gaagatggca tt                                               22

<210>  8317
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8317
caacatcaag gaagatggca t                                                21

<210>  8318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8318
caacatcaag gaagatggca                                                  20

<210>  8319
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8319
caacatcaag gaagatggc                                                   19

<210>  8320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8320
caacatcaag gaagatgg                                                    18

<210>  8321
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8321
caacatcaag gaagatg                                                     17

<210>  8322
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8322
caacatcaag gaagat                                                      16

<210>  8323
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8323
caacatcaag gaaga                                                       15

<210>  8324
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8324
caacatcaag gaag                                                        14

<210>  8325
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  8325
aacatcaagg aagatggcat ttctag                                           26

<210>  8326
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  8326
aacatcaagg aagatggcat ttcta                                            25

<210>  8327
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8327
aacatcaagg aagatggcat ttct                                             24

<210>  8328
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8328
aacatcaagg aagatggcat ttc                                              23

<210>  8329
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8329
aacatcaagg aagatggcat tt                                               22

<210>  8330
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8330
aacatcaagg aagatggcat t                                                21

<210>  8331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8331
aacatcaagg aagatggcat                                                  20

<210>  8332
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8332
aacatcaagg aagatggca                                                   19

<210>  8333
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8333
aacatcaagg aagatggc                                                    18

<210>  8334
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8334
aacatcaagg aagatgg                                                     17

<210>  8335
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8335
aacatcaagg aagatg                                                      16

<210>  8336
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8336
aacatcaagg aagat                                                       15

<210>  8337
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8337
aacatcaagg aaga                                                        14

<210>  8338
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8338
aacatcaagg aag                                                         13

<210>  8339
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  8339
acatcaagga agatggcatt tctag                                            25

<210>  8340
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8340
acatcaagga agatggcatt tcta                                             24

<210>  8341
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8341
acatcaagga agatggcatt tct                                              23

<210>  8342
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8342
acatcaagga agatggcatt tc                                               22

<210>  8343
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8343
acatcaagga agatggcatt t                                                21

<210>  8344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8344
acatcaagga agatggcatt                                                  20

<210>  8345
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8345
acatcaagga agatggcat                                                   19

<210>  8346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8346
acatcaagga agatggca                                                    18

<210>  8347
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8347
acatcaagga agatggc                                                     17

<210>  8348
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8348
acatcaagga agatgg                                                      16

<210>  8349
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8349
acatcaagga agatg                                                       15

<210>  8350
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8350
acatcaagga agat                                                        14

<210>  8351
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8351
acatcaagga aga                                                         13

<210>  8352
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8352
acatcaagga ag                                                          12

<210>  8353
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  8353
catcaaggaa gatggcattt ctag                                             24

<210>  8354
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8354
catcaaggaa gatggcattt cta                                              23

<210>  8355
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8355
catcaaggaa gatggcattt ct                                               22

<210>  8356
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8356
catcaaggaa gatggcattt c                                                21

<210>  8357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8357
catcaaggaa gatggcattt                                                  20

<210>  8358
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8358
catcaaggaa gatggcatt                                                   19

<210>  8359
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8359
catcaaggaa gatggcat                                                    18

<210>  8360
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8360
catcaaggaa gatggca                                                     17

<210>  8361
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8361
catcaaggaa gatggc                                                      16

<210>  8362
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8362
catcaaggaa gatgg                                                       15

<210>  8363
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8363
catcaaggaa gatg                                                        14

<210>  8364
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8364
catcaaggaa gat                                                         13

<210>  8365
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8365
catcaaggaa ga                                                          12

<210>  8366
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8366
catcaaggaa g                                                           11

<210>  8367
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  8367
atcaaggaag atggcatttc tag                                              23

<210>  8368
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8368
atcaaggaag atggcatttc ta                                               22

<210>  8369
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8369
atcaaggaag atggcatttc t                                                21

<210>  8370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8370
atcaaggaag atggcatttc                                                  20

<210>  8371
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8371
atcaaggaag atggcattt                                                   19

<210>  8372
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8372
atcaaggaag atggcatt                                                    18

<210>  8373
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8373
atcaaggaag atggcat                                                     17

<210>  8374
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8374
atcaaggaag atggca                                                      16

<210>  8375
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8375
atcaaggaag atggc                                                       15

<210>  8376
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8376
atcaaggaag atgg                                                        14

<210>  8377
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8377
atcaaggaag atg                                                         13

<210>  8378
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8378
atcaaggaag at                                                          12

<210>  8379
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8379
atcaaggaag a                                                           11

<210>  8380
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8380
atcaaggaag                                                             10

<210>  8381
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  8381
ggtaagttct gtccaagc                                                    18

<210>  8382
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  8382
gtaagttctg tccaagcc                                                    18

<210>  8383
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  8383
agtcggtaag ttctgtcc                                                    18

<210>  8384
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8384
ctgtccaagc ccggttga                                                    18

<210>  8385
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  8385
taagttctgt ccaag                                                       15

<210>  8386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8386
ttctgtccaa gcccggttga                                                  20

<210>  8387
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8387
ttctgtccaa gcccggttg                                                   19

<210>  8388
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8388
ttctgtccaa gcccggtt                                                    18

<210>  8389
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8389
ttctgtccaa gcccggt                                                     17

<210>  8390
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8390
ttctgtccaa gcccgg                                                      16

<210>  8391
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8391
ttctgtccaa gcccg                                                       15

<210>  8392
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  8392
ttctgtccaa gccc                                                        14

<210>  8393
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  8393
ttctgtccaa gcc                                                         13

<210>  8394
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8394
ttctgtccaa gc                                                          12

<210>  8395
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  8395
ttctgtccaa g                                                           11

<210>  8396
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  8396
ttctgtccaa                                                             10

<210>  8397
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  8397
ttctgtcca                                                              9

<210>  8398
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  8398
ttctgtcc                                                               8

<210>  8399
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8399
tctgtccaag cccggttga                                                   19

<210>  8400
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8400
tctgtccaag cccggttg                                                    18

<210>  8401
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8401
tctgtccaag cccggtt                                                     17

<210>  8402
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8402
tctgtccaag cccggt                                                      16

<210>  8403
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8403
tctgtccaag cccgg                                                       15

<210>  8404
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8404
tctgtccaag cccg                                                        14

<210>  8405
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  8405
tctgtccaag ccc                                                         13

<210>  8406
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  8406
tctgtccaag cc                                                          12

<210>  8407
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8407
tctgtccaag c                                                           11

<210>  8408
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  8408
tctgtccaag                                                             10

<210>  8409
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  8409
tctgtccaa                                                              9

<210>  8410
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  8410
tctgtcca                                                               8

<210>  8411
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8411
ctgtccaagc ccggttg                                                     17

<210>  8412
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8412
ctgtccaagc ccggtt                                                      16

<210>  8413
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8413
ctgtccaagc ccggt                                                       15

<210>  8414
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8414
ctgtccaagc ccgg                                                        14

<210>  8415
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8415
ctgtccaagc ccg                                                         13

<210>  8416
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8416
ctgtccaagc cc                                                          12

<210>  8417
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8417
ctgtccaagc c                                                           11

<210>  8418
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8418
ctgtccaagc                                                             10

<210>  8419
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8419
ctgtccaag                                                              9

<210>  8420
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8420
ctgtccaa                                                               8

<210>  8421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  8421
gttctgtcca agcccggttg                                                  20

<210>  8422
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  8422
gttctgtcca agcccggtt                                                   19

<210>  8423
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  8423
gttctgtcca agcccggt                                                    18

<210>  8424
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  8424
gttctgtcca agcccgg                                                     17

<210>  8425
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  8425
gttctgtcca agcccg                                                      16

<210>  8426
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  8426
gttctgtcca agccc                                                       15

<210>  8427
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  8427
gttctgtcca agcc                                                        14

<210>  8428
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8428
gttctgtcca agc                                                         13

<210>  8429
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  8429
gttctgtcca ag                                                          12

<210>  8430
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  8430
gttctgtcca a                                                           11

<210>  8431
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  8431
gttctgtcca                                                             10

<210>  8432
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  8432
gttctgtcc                                                              9

<210>  8433
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8433
gttctgtc                                                               8

<210>  8434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  8434
agttctgtcc aagcccggtt                                                  20

<210>  8435
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  8435
agttctgtcc aagcccggt                                                   19

<210>  8436
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  8436
agttctgtcc aagcccgg                                                    18

<210>  8437
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  8437
agttctgtcc aagcccg                                                     17

<210>  8438
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  8438
agttctgtcc aagccc                                                      16

<210>  8439
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  8439
agttctgtcc aagcc                                                       15

<210>  8440
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8440
agttctgtcc aagc                                                        14

<210>  8441
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  8441
agttctgtcc aag                                                         13

<210>  8442
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  8442
agttctgtcc aa                                                          12

<210>  8443
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  8443
agttctgtcc a                                                           11

<210>  8444
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  8444
agttctgtcc                                                             10

<210>  8445
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8445
agttctgtc                                                              9

<210>  8446
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  8446
agttctgt                                                               8

<210>  8447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  8447
aagttctgtc caagcccggt                                                  20

<210>  8448
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  8448
aagttctgtc caagcccgg                                                   19

<210>  8449
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  8449
aagttctgtc caagcccg                                                    18

<210>  8450
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  8450
aagttctgtc caagccc                                                     17

<210>  8451
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  8451
aagttctgtc caagcc                                                      16

<210>  8452
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8452
aagttctgtc caagc                                                       15

<210>  8453
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  8453
aagttctgtc caag                                                        14

<210>  8454
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  8454
aagttctgtc caa                                                         13

<210>  8455
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  8455
aagttctgtc ca                                                          12

<210>  8456
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  8456
aagttctgtc c                                                           11

<210>  8457
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  8457
aagttctgtc                                                             10

<210>  8458
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8458
aagttctgt                                                              9

<210>  8459
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8459
aagttctg                                                               8

<210>  8460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  8460
taagttctgt ccaagcccgg                                                  20

<210>  8461
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  8461
taagttctgt ccaagcccg                                                   19

<210>  8462
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  8462
taagttctgt ccaagccc                                                    18

<210>  8463
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  8463
taagttctgt ccaagcc                                                     17

<210>  8464
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8464
taagttctgt ccaagc                                                      16

<210>  8465
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  8465
taagttctgt ccaa                                                        14

<210>  8466
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  8466
taagttctgt cca                                                         13

<210>  8467
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  8467
taagttctgt cc                                                          12

<210>  8468
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8468
taagttctgt c                                                           11

<210>  8469
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8469
taagttctgt                                                             10

<210>  8470
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8470
taagttctg                                                              9

<210>  8471
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8471
taagttct                                                               8

<210>  8472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  8472
gtaagttctg tccaagcccg                                                  20

<210>  8473
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  8473
gtaagttctg tccaagccc                                                   19

<210>  8474
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8474
gtaagttctg tccaagc                                                     17

<210>  8475
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  8475
gtaagttctg tccaag                                                      16

<210>  8476
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  8476
gtaagttctg tccaa                                                       15

<210>  8477
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  8477
gtaagttctg tcca                                                        14

<210>  8478
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  8478
gtaagttctg tcc                                                         13

<210>  8479
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8479
gtaagttctg tc                                                          12

<210>  8480
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8480
gtaagttctg t                                                           11

<210>  8481
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8481
gtaagttctg                                                             10

<210>  8482
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8482
gtaagttct                                                              9

<210>  8483
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8483
gtaagttc                                                               8

<210>  8484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  8484
ggtaagttct gtccaagccc                                                  20

<210>  8485
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  8485
ggtaagttct gtccaagcc                                                   19

<210>  8486
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  8486
ggtaagttct gtccaag                                                     17

<210>  8487
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  8487
ggtaagttct gtccaa                                                      16

<210>  8488
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  8488
ggtaagttct gtcca                                                       15

<210>  8489
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  8489
ggtaagttct gtcc                                                        14

<210>  8490
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8490
ggtaagttct gtc                                                         13

<210>  8491
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8491
ggtaagttct gt                                                          12

<210>  8492
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8492
ggtaagttct g                                                           11

<210>  8493
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8493
ggtaagttct                                                             10

<210>  8494
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8494
ggtaagttc                                                              9

<210>  8495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8495
cggtaagttc tgtccaagcc                                                  20

<210>  8496
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8496
cggtaagttc tgtccaagc                                                   19

<210>  8497
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8497
cggtaagttc tgtccaag                                                    18

<210>  8498
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8498
cggtaagttc tgtccaa                                                     17

<210>  8499
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8499
cggtaagttc tgtcca                                                      16

<210>  8500
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8500
cggtaagttc tgtcc                                                       15

<210>  8501
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8501
cggtaagttc tgtc                                                        14

<210>  8502
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8502
cggtaagttc tgt                                                         13

<210>  8503
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8503
cggtaagttc tg                                                          12

<210>  8504
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8504
cggtaagttc t                                                           11

<210>  8505
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8505
cggtaagttc                                                             10

<210>  8506
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8506
cggtaagtt                                                              9

<210>  8507
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8507
cggtaagt                                                               8

<210>  8508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  8508
tcggtaagtt ctgtccaagc                                                  20

<210>  8509
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  8509
tcggtaagtt ctgtccaag                                                   19

<210>  8510
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  8510
tcggtaagtt ctgtccaa                                                    18

<210>  8511
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  8511
tcggtaagtt ctgtcca                                                     17

<210>  8512
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  8512
tcggtaagtt ctgtcc                                                      16

<210>  8513
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8513
tcggtaagtt ctgtc                                                       15

<210>  8514
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8514
tcggtaagtt ctgt                                                        14

<210>  8515
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8515
tcggtaagtt ctg                                                         13

<210>  8516
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8516
tcggtaagtt ct                                                          12

<210>  8517
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8517
tcggtaagtt c                                                           11

<210>  8518
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8518
tcggtaagtt                                                             10

<210>  8519
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8519
tcggtaagt                                                              9

<210>  8520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  8520
gtcggtaagt tctgtccaag                                                  20

<210>  8521
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  8521
gtcggtaagt tctgtccaa                                                   19

<210>  8522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  8522
gtcggtaagt tctgtcca                                                    18

<210>  8523
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  8523
gtcggtaagt tctgtcc                                                     17

<210>  8524
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8524
gtcggtaagt tctgtc                                                      16

<210>  8525
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8525
gtcggtaagt tctgt                                                       15

<210>  8526
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8526
gtcggtaagt tctg                                                        14

<210>  8527
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8527
gtcggtaagt tct                                                         13

<210>  8528
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8528
gtcggtaagt tc                                                          12

<210>  8529
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8529
gtcggtaagt t                                                           11

<210>  8530
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8530
gtcggtaagt                                                             10

<210>  8531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  8531
agtcggtaag ttctgtccaa                                                  20

<210>  8532
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  8532
agtcggtaag ttctgtcca                                                   19

<210>  8533
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8533
agtcggtaag ttctgtc                                                     17

<210>  8534
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8534
agtcggtaag ttctgt                                                      16

<210>  8535
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8535
agtcggtaag ttctg                                                       15

<210>  8536
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8536
agtcggtaag ttct                                                        14

<210>  8537
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8537
agtcggtaag ttc                                                         13

<210>  8538
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  8538
agtcggtaag tt                                                          12

<210>  8539
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  8539
agtcggtaag t                                                           11

<210>  8540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8540
cagtcggtaa gttctgtcca                                                  20

<210>  8541
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8541
cagtcggtaa gttctgtcc                                                   19

<210>  8542
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8542
cagtcggtaa gttctgtc                                                    18

<210>  8543
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8543
cagtcggtaa gttctgt                                                     17

<210>  8544
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8544
cagtcggtaa gttctg                                                      16

<210>  8545
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8545
cagtcggtaa gttct                                                       15

<210>  8546
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8546
cagtcggtaa gttc                                                        14

<210>  8547
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8547
cagtcggtaa gtt                                                         13

<210>  8548
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8548
cagtcggtaa gt                                                          12

<210>  8549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8549
ccagtcggta agttctgtcc                                                  20

<210>  8550
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8550
ccagtcggta agttctgtc                                                   19

<210>  8551
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8551
ccagtcggta agttctgt                                                    18

<210>  8552
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8552
ccagtcggta agttctg                                                     17

<210>  8553
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8553
ccagtcggta agttct                                                      16

<210>  8554
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8554
ccagtcggta agttc                                                       15

<210>  8555
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8555
ccagtcggta agtt                                                        14

<210>  8556
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8556
ccagtcggta agt                                                         13

<210>  8557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  8557
gccagtcggt aagttctgtc                                                  20

<210>  8558
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8558
gccagtcggt aagttctgt                                                   19

<210>  8559
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8559
gccagtcggt aagttctg                                                    18

<210>  8560
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8560
gccagtcggt aagttct                                                     17

<210>  8561
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8561
gccagtcggt aagttc                                                      16

<210>  8562
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8562
gccagtcggt aagtt                                                       15

<210>  8563
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8563
gccagtcggt aagt                                                        14

<210>  8564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  8564
tcaaggaaga tggcatttct                                                  20

<210>  8565
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  8565
tcaaggaaga tggcatttct ag                                               22

<210>  8566
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8566
tcaaggaaga tggcat                                                      16

<210>  8567
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8567
gaagatggca tttct                                                       15

<210>  8568
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  8568
tcaaggaaga tggcatttct a                                                21

<210>  8569
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  8569
tcaaggaaga tggcatttc                                                   19

<210>  8570
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8570
tcaaggaaga tggcattt                                                    18

<210>  8571
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8571
tcaaggaaga tggcatt                                                     17

<210>  8572
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8572
tcaaggaaga tggca                                                       15

<210>  8573
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8573
tcaaggaaga tggc                                                        14

<210>  8574
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8574
tcaaggaaga tgg                                                         13

<210>  8575
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8575
tcaaggaaga tg                                                          12

<210>  8576
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8576
tcaaggaaga t                                                           11

<210>  8577
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8577
tcaaggaaga                                                             10

<210>  8578
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  8578
tcaaggaag                                                              9

<210>  8579
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8579
caaggaagat ggcatttcta g                                                21

<210>  8580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8580
caaggaagat ggcatttcta                                                  20

<210>  8581
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8581
caaggaagat ggcatttct                                                   19

<210>  8582
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8582
caaggaagat ggcatttc                                                    18

<210>  8583
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8583
caaggaagat ggcattt                                                     17

<210>  8584
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8584
caaggaagat ggcatt                                                      16

<210>  8585
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8585
caaggaagat ggcat                                                       15

<210>  8586
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8586
caaggaagat ggca                                                        14

<210>  8587
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8587
caaggaagat ggc                                                         13

<210>  8588
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8588
caaggaagat gg                                                          12

<210>  8589
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8589
caaggaagat g                                                           11

<210>  8590
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8590
caaggaagat                                                             10

<210>  8591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8591
aaggaagatg gcatttctag                                                  20

<210>  8592
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8592
aaggaagatg gcatttcta                                                   19

<210>  8593
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8593
aaggaagatg gcatttct                                                    18

<210>  8594
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8594
aaggaagatg gcatttc                                                     17

<210>  8595
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8595
aaggaagatg gcattt                                                      16

<210>  8596
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8596
aaggaagatg gcatt                                                       15

<210>  8597
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8597
aaggaagatg gcat                                                        14

<210>  8598
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8598
aaggaagatg gca                                                         13

<210>  8599
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8599
aaggaagatg gc                                                          12

<210>  8600
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8600
aggaagatgg catttctag                                                   19

<210>  8601
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8601
aggaagatgg catttcta                                                    18

<210>  8602
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8602
aggaagatgg catttct                                                     17

<210>  8603
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  8603
aggaagatgg catttc                                                      16

<210>  8604
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8604
aggaagatgg cattt                                                       15

<210>  8605
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8605
aggaagatgg catt                                                        14

<210>  8606
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8606
aggaagatgg cat                                                         13

<210>  8607
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  8607
aggaagatgg ca                                                          12

<210>  8608
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8608
ggaagatggc atttctag                                                    18

<210>  8609
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8609
ggaagatggc atttcta                                                     17

<210>  8610
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8610
ggaagatggc atttct                                                      16

<210>  8611
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8611
ggaagatggc atttc                                                       15

<210>  8612
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  8612
ggaagatggc attt                                                        14

<210>  8613
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  8613
ggaagatggc att                                                         13

<210>  8614
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  8614
ggaagatggc at                                                          12

<210>  8615
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  8615
ggaagatggc a                                                           11

<210>  8616
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  8616
ggaagatggc                                                             10

<210>  8617
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8617
gaagatggca tttctag                                                     17

<210>  8618
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8618
gaagatggca tttcta                                                      16

<210>  8619
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  8619
gaagatggca tttc                                                        14

<210>  8620
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8620
gaagatggca ttt                                                         13

<210>  8621
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8621
gaagatggca tt                                                          12

<210>  8622
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8622
gaagatggca t                                                           11

<210>  8623
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8623
gaagatggca                                                             10

<210>  8624
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8624
gaagatggc                                                              9

<210>  8625
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8625
aagatggcat ttctag                                                      16

<210>  8626
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8626
aagatggcat ttcta                                                       15

<210>  8627
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8627
aagatggcat ttct                                                        14

<210>  8628
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  8628
aagatggcat ttc                                                         13

<210>  8629
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8629
aagatggcat tt                                                          12

<210>  8630
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8630
aagatggcat t                                                           11

<210>  8631
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8631
aagatggcat                                                             10

<210>  8632
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8632
aagatggca                                                              9

<210>  8633
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  8633
aagatggc                                                               8

<210>  8634
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8634
agatggcatt tctag                                                       15

<210>  8635
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8635
agatggcatt tcta                                                        14

<210>  8636
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8636
agatggcatt tct                                                         13

<210>  8637
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  8637
agatggcatt tc                                                          12

<210>  8638
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8638
agatggcatt t                                                           11

<210>  8639
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8639
agatggcatt                                                             10

<210>  8640
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8640
agatggcat                                                              9

<210>  8641
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  8641
agatggca                                                               8

<210>  8642
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8642
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  8643
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8643
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  8644
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8644
ctccaacatc aaggaagatg gcatttct                                         28

<210>  8645
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8645
ctccaacatc aaggaagatg gcatttc                                          27

<210>  8646
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8646
ctccaacatc aaggaagatg gcattt                                           26

<210>  8647
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8647
ctccaacatc aaggaagatg gcatt                                            25

<210>  8648
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8648
ctccaacatc aaggaagatg gcat                                             24

<210>  8649
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8649
ctccaacatc aaggaagatg gca                                              23

<210>  8650
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8650
ctccaacatc aaggaagatg gc                                               22

<210>  8651
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8651
ctccaacatc aaggaagatg g                                                21

<210>  8652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8652
ctccaacatc aaggaagatg                                                  20

<210>  8653
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8653
ctccaacatc aaggaagat                                                   19

<210>  8654
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8654
ctccaacatc aaggaaga                                                    18

<210>  8655
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8655
ctccaacatc aaggaag                                                     17

<210>  8656
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  8656
tccaacatca aggaagatgg catttctag                                        29

<210>  8657
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  8657
tccaacatca aggaagatgg catttcta                                         28

<210>  8658
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  8658
tccaacatca aggaagatgg catttct                                          27

<210>  8659
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  8659
tccaacatca aggaagatgg catttc                                           26

<210>  8660
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  8660
tccaacatca aggaagatgg cattt                                            25

<210>  8661
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  8661
tccaacatca aggaagatgg catt                                             24

<210>  8662
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  8662
tccaacatca aggaagatgg cat                                              23

<210>  8663
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  8663
tccaacatca aggaagatgg ca                                               22

<210>  8664
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  8664
tccaacatca aggaagatgg c                                                21

<210>  8665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8665
tccaacatca aggaagatgg                                                  20

<210>  8666
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8666
tccaacatca aggaagatg                                                   19

<210>  8667
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8667
tccaacatca aggaagat                                                    18

<210>  8668
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8668
tccaacatca aggaaga                                                     17

<210>  8669
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  8669
tccaacatca aggaag                                                      16

<210>  8670
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8670
ccaacatcaa ggaagatggc atttctag                                         28

<210>  8671
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8671
ccaacatcaa ggaagatggc atttcta                                          27

<210>  8672
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8672
ccaacatcaa ggaagatggc atttct                                           26

<210>  8673
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8673
ccaacatcaa ggaagatggc atttc                                            25

<210>  8674
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8674
ccaacatcaa ggaagatggc attt                                             24

<210>  8675
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8675
ccaacatcaa ggaagatggc att                                              23

<210>  8676
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8676
ccaacatcaa ggaagatggc at                                               22

<210>  8677
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8677
ccaacatcaa ggaagatggc a                                                21

<210>  8678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8678
ccaacatcaa ggaagatggc                                                  20

<210>  8679
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8679
ccaacatcaa ggaagatgg                                                   19

<210>  8680
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8680
ccaacatcaa ggaagatg                                                    18

<210>  8681
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8681
ccaacatcaa ggaagat                                                     17

<210>  8682
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8682
ccaacatcaa ggaaga                                                      16

<210>  8683
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8683
ccaacatcaa ggaag                                                       15

<210>  8684
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8684
caacatcaag gaagatggca tttctag                                          27

<210>  8685
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8685
caacatcaag gaagatggca tttcta                                           26

<210>  8686
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8686
caacatcaag gaagatggca tttct                                            25

<210>  8687
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8687
caacatcaag gaagatggca tttc                                             24

<210>  8688
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8688
caacatcaag gaagatggca ttt                                              23

<210>  8689
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8689
caacatcaag gaagatggca tt                                               22

<210>  8690
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8690
caacatcaag gaagatggca t                                                21

<210>  8691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8691
caacatcaag gaagatggca                                                  20

<210>  8692
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8692
caacatcaag gaagatggc                                                   19

<210>  8693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8693
caacatcaag gaagatgg                                                    18

<210>  8694
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8694
caacatcaag gaagatg                                                     17

<210>  8695
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8695
caacatcaag gaagat                                                      16

<210>  8696
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8696
caacatcaag gaaga                                                       15

<210>  8697
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8697
caacatcaag gaag                                                        14

<210>  8698
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  8698
aacatcaagg aagatggcat ttctag                                           26

<210>  8699
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  8699
aacatcaagg aagatggcat ttcta                                            25

<210>  8700
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  8700
aacatcaagg aagatggcat ttct                                             24

<210>  8701
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  8701
aacatcaagg aagatggcat ttc                                              23

<210>  8702
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  8702
aacatcaagg aagatggcat tt                                               22

<210>  8703
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  8703
aacatcaagg aagatggcat t                                                21

<210>  8704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  8704
aacatcaagg aagatggcat                                                  20

<210>  8705
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  8705
aacatcaagg aagatggca                                                   19

<210>  8706
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  8706
aacatcaagg aagatggc                                                    18

<210>  8707
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8707
aacatcaagg aagatgg                                                     17

<210>  8708
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8708
aacatcaagg aagatg                                                      16

<210>  8709
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8709
aacatcaagg aagat                                                       15

<210>  8710
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8710
aacatcaagg aaga                                                        14

<210>  8711
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  8711
aacatcaagg aag                                                         13

<210>  8712
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  8712
acatcaagga agatggcatt tctag                                            25

<210>  8713
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  8713
acatcaagga agatggcatt tcta                                             24

<210>  8714
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  8714
acatcaagga agatggcatt tct                                              23

<210>  8715
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  8715
acatcaagga agatggcatt tc                                               22

<210>  8716
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8716
acatcaagga agatggcatt t                                                21

<210>  8717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8717
acatcaagga agatggcatt                                                  20

<210>  8718
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8718
acatcaagga agatggcat                                                   19

<210>  8719
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8719
acatcaagga agatggca                                                    18

<210>  8720
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  8720
acatcaagga agatggc                                                     17

<210>  8721
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  8721
acatcaagga agatgg                                                      16

<210>  8722
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  8722
acatcaagga agatg                                                       15

<210>  8723
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  8723
acatcaagga agat                                                        14

<210>  8724
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  8724
acatcaagga aga                                                         13

<210>  8725
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  8725
acatcaagga ag                                                          12

<210>  8726
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8726
catcaaggaa gatggcattt ctag                                             24

<210>  8727
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8727
catcaaggaa gatggcattt cta                                              23

<210>  8728
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8728
catcaaggaa gatggcattt ct                                               22

<210>  8729
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8729
catcaaggaa gatggcattt c                                                21

<210>  8730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8730
catcaaggaa gatggcattt                                                  20

<210>  8731
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8731
catcaaggaa gatggcatt                                                   19

<210>  8732
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8732
catcaaggaa gatggcat                                                    18

<210>  8733
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8733
catcaaggaa gatggca                                                     17

<210>  8734
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8734
catcaaggaa gatggc                                                      16

<210>  8735
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8735
catcaaggaa gatgg                                                       15

<210>  8736
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8736
catcaaggaa gatg                                                        14

<210>  8737
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8737
catcaaggaa gat                                                         13

<210>  8738
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8738
catcaaggaa ga                                                          12

<210>  8739
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  8739
catcaaggaa g                                                           11

<210>  8740
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  8740
atcaaggaag atggcatttc tag                                              23

<210>  8741
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  8741
atcaaggaag atggcatttc ta                                               22

<210>  8742
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  8742
atcaaggaag atggcatttc t                                                21

<210>  8743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  8743
atcaaggaag atggcatttc                                                  20

<210>  8744
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8744
atcaaggaag atggcattt                                                   19

<210>  8745
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8745
atcaaggaag atggcatt                                                    18

<210>  8746
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8746
atcaaggaag atggcat                                                     17

<210>  8747
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8747
atcaaggaag atggca                                                      16

<210>  8748
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  8748
atcaaggaag atggc                                                       15

<210>  8749
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8749
atcaaggaag atgg                                                        14

<210>  8750
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8750
atcaaggaag atg                                                         13

<210>  8751
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8751
atcaaggaag at                                                          12

<210>  8752
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8752
atcaaggaag a                                                           11

<210>  8753
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  8753
atcaaggaag                                                             10

<210>  8754
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8754
ggtaagttct gtccaagc                                                    18

<210>  8755
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8755
gtaagttctg tccaagcc                                                    18

<210>  8756
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8756
agtcggtaag ttctgtcc                                                    18

<210>  8757
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8757
ctgtccaagc ccggttga                                                    18

<210>  8758
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8758
taagttctgt ccaag                                                       15

<210>  8759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8759
ttctgtccaa gcccggttga                                                  20

<210>  8760
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8760
ttctgtccaa gcccggttg                                                   19

<210>  8761
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8761
ttctgtccaa gcccggtt                                                    18

<210>  8762
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8762
ttctgtccaa gcccggt                                                     17

<210>  8763
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8763
ttctgtccaa gcccgg                                                      16

<210>  8764
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8764
ttctgtccaa gcccg                                                       15

<210>  8765
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8765
ttctgtccaa gccc                                                        14

<210>  8766
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8766
ttctgtccaa gcc                                                         13

<210>  8767
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8767
ttctgtccaa gc                                                          12

<210>  8768
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8768
ttctgtccaa g                                                           11

<210>  8769
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8769
ttctgtccaa                                                             10

<210>  8770
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8770
ttctgtcca                                                              9

<210>  8771
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8771
ttctgtcc                                                               8

<210>  8772
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8772
tctgtccaag cccggttga                                                   19

<210>  8773
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8773
tctgtccaag cccggttg                                                    18

<210>  8774
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8774
tctgtccaag cccggtt                                                     17

<210>  8775
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8775
tctgtccaag cccggt                                                      16

<210>  8776
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8776
tctgtccaag cccgg                                                       15

<210>  8777
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8777
tctgtccaag cccg                                                        14

<210>  8778
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8778
tctgtccaag ccc                                                         13

<210>  8779
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8779
tctgtccaag cc                                                          12

<210>  8780
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8780
tctgtccaag c                                                           11

<210>  8781
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8781
tctgtccaag                                                             10

<210>  8782
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8782
tctgtccaa                                                              9

<210>  8783
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8783
tctgtcca                                                               8

<210>  8784
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8784
ctgtccaagc ccggttg                                                     17

<210>  8785
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8785
ctgtccaagc ccggtt                                                      16

<210>  8786
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8786
ctgtccaagc ccggt                                                       15

<210>  8787
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8787
ctgtccaagc ccgg                                                        14

<210>  8788
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8788
ctgtccaagc ccg                                                         13

<210>  8789
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8789
ctgtccaagc cc                                                          12

<210>  8790
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8790
ctgtccaagc c                                                           11

<210>  8791
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8791
ctgtccaagc                                                             10

<210>  8792
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8792
ctgtccaag                                                              9

<210>  8793
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8793
ctgtccaa                                                               8

<210>  8794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8794
gttctgtcca agcccggttg                                                  20

<210>  8795
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8795
gttctgtcca agcccggtt                                                   19

<210>  8796
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8796
gttctgtcca agcccggt                                                    18

<210>  8797
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8797
gttctgtcca agcccgg                                                     17

<210>  8798
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8798
gttctgtcca agcccg                                                      16

<210>  8799
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8799
gttctgtcca agccc                                                       15

<210>  8800
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8800
gttctgtcca agcc                                                        14

<210>  8801
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8801
gttctgtcca agc                                                         13

<210>  8802
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8802
gttctgtcca ag                                                          12

<210>  8803
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8803
gttctgtcca a                                                           11

<210>  8804
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8804
gttctgtcca                                                             10

<210>  8805
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8805
gttctgtcc                                                              9

<210>  8806
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8806
gttctgtc                                                               8

<210>  8807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8807
agttctgtcc aagcccggtt                                                  20

<210>  8808
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8808
agttctgtcc aagcccggt                                                   19

<210>  8809
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8809
agttctgtcc aagcccgg                                                    18

<210>  8810
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8810
agttctgtcc aagcccg                                                     17

<210>  8811
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8811
agttctgtcc aagccc                                                      16

<210>  8812
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8812
agttctgtcc aagcc                                                       15

<210>  8813
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8813
agttctgtcc aagc                                                        14

<210>  8814
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8814
agttctgtcc aag                                                         13

<210>  8815
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8815
agttctgtcc aa                                                          12

<210>  8816
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8816
agttctgtcc a                                                           11

<210>  8817
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8817
agttctgtcc                                                             10

<210>  8818
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8818
agttctgtc                                                              9

<210>  8819
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8819
agttctgt                                                               8

<210>  8820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8820
aagttctgtc caagcccggt                                                  20

<210>  8821
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8821
aagttctgtc caagcccgg                                                   19

<210>  8822
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8822
aagttctgtc caagcccg                                                    18

<210>  8823
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8823
aagttctgtc caagccc                                                     17

<210>  8824
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8824
aagttctgtc caagcc                                                      16

<210>  8825
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8825
aagttctgtc caagc                                                       15

<210>  8826
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8826
aagttctgtc caag                                                        14

<210>  8827
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8827
aagttctgtc caa                                                         13

<210>  8828
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8828
aagttctgtc ca                                                          12

<210>  8829
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8829
aagttctgtc c                                                           11

<210>  8830
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8830
aagttctgtc                                                             10

<210>  8831
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8831
aagttctgt                                                              9

<210>  8832
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8832
aagttctg                                                               8

<210>  8833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8833
taagttctgt ccaagcccgg                                                  20

<210>  8834
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8834
taagttctgt ccaagcccg                                                   19

<210>  8835
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8835
taagttctgt ccaagccc                                                    18

<210>  8836
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8836
taagttctgt ccaagcc                                                     17

<210>  8837
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8837
taagttctgt ccaagc                                                      16

<210>  8838
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8838
taagttctgt ccaa                                                        14

<210>  8839
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8839
taagttctgt cca                                                         13

<210>  8840
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8840
taagttctgt cc                                                          12

<210>  8841
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8841
taagttctgt c                                                           11

<210>  8842
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8842
taagttctgt                                                             10

<210>  8843
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8843
taagttctg                                                              9

<210>  8844
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8844
taagttct                                                               8

<210>  8845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8845
gtaagttctg tccaagcccg                                                  20

<210>  8846
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8846
gtaagttctg tccaagccc                                                   19

<210>  8847
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8847
gtaagttctg tccaagc                                                     17

<210>  8848
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8848
gtaagttctg tccaag                                                      16

<210>  8849
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8849
gtaagttctg tccaa                                                       15

<210>  8850
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8850
gtaagttctg tcca                                                        14

<210>  8851
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8851
gtaagttctg tcc                                                         13

<210>  8852
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8852
gtaagttctg tc                                                          12

<210>  8853
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8853
gtaagttctg t                                                           11

<210>  8854
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8854
gtaagttctg                                                             10

<210>  8855
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8855
gtaagttct                                                              9

<210>  8856
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8856
gtaagttc                                                               8

<210>  8857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8857
ggtaagttct gtccaagccc                                                  20

<210>  8858
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8858
ggtaagttct gtccaagcc                                                   19

<210>  8859
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8859
ggtaagttct gtccaag                                                     17

<210>  8860
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8860
ggtaagttct gtccaa                                                      16

<210>  8861
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8861
ggtaagttct gtcca                                                       15

<210>  8862
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8862
ggtaagttct gtcc                                                        14

<210>  8863
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8863
ggtaagttct gtc                                                         13

<210>  8864
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8864
ggtaagttct gt                                                          12

<210>  8865
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8865
ggtaagttct g                                                           11

<210>  8866
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8866
ggtaagttct                                                             10

<210>  8867
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8867
ggtaagttc                                                              9

<210>  8868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8868
cggtaagttc tgtccaagcc                                                  20

<210>  8869
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8869
cggtaagttc tgtccaagc                                                   19

<210>  8870
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8870
cggtaagttc tgtccaag                                                    18

<210>  8871
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8871
cggtaagttc tgtccaa                                                     17

<210>  8872
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8872
cggtaagttc tgtcca                                                      16

<210>  8873
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8873
cggtaagttc tgtcc                                                       15

<210>  8874
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8874
cggtaagttc tgtc                                                        14

<210>  8875
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8875
cggtaagttc tgt                                                         13

<210>  8876
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8876
cggtaagttc tg                                                          12

<210>  8877
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8877
cggtaagttc t                                                           11

<210>  8878
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8878
cggtaagttc                                                             10

<210>  8879
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8879
cggtaagtt                                                              9

<210>  8880
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  8880
cggtaagt                                                               8

<210>  8881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8881
tcggtaagtt ctgtccaagc                                                  20

<210>  8882
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8882
tcggtaagtt ctgtccaag                                                   19

<210>  8883
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8883
tcggtaagtt ctgtccaa                                                    18

<210>  8884
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8884
tcggtaagtt ctgtcca                                                     17

<210>  8885
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8885
tcggtaagtt ctgtcc                                                      16

<210>  8886
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8886
tcggtaagtt ctgtc                                                       15

<210>  8887
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8887
tcggtaagtt ctgt                                                        14

<210>  8888
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8888
tcggtaagtt ctg                                                         13

<210>  8889
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8889
tcggtaagtt ct                                                          12

<210>  8890
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8890
tcggtaagtt c                                                           11

<210>  8891
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8891
tcggtaagtt                                                             10

<210>  8892
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8892
tcggtaagt                                                              9

<210>  8893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8893
gtcggtaagt tctgtccaag                                                  20

<210>  8894
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8894
gtcggtaagt tctgtccaa                                                   19

<210>  8895
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8895
gtcggtaagt tctgtcca                                                    18

<210>  8896
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8896
gtcggtaagt tctgtcc                                                     17

<210>  8897
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8897
gtcggtaagt tctgtc                                                      16

<210>  8898
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8898
gtcggtaagt tctgt                                                       15

<210>  8899
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8899
gtcggtaagt tctg                                                        14

<210>  8900
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8900
gtcggtaagt tct                                                         13

<210>  8901
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8901
gtcggtaagt tc                                                          12

<210>  8902
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8902
gtcggtaagt t                                                           11

<210>  8903
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8903
gtcggtaagt                                                             10

<210>  8904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8904
agtcggtaag ttctgtccaa                                                  20

<210>  8905
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8905
agtcggtaag ttctgtcca                                                   19

<210>  8906
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8906
agtcggtaag ttctgtc                                                     17

<210>  8907
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8907
agtcggtaag ttctgt                                                      16

<210>  8908
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8908
agtcggtaag ttctg                                                       15

<210>  8909
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8909
agtcggtaag ttct                                                        14

<210>  8910
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8910
agtcggtaag ttc                                                         13

<210>  8911
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8911
agtcggtaag tt                                                          12

<210>  8912
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8912
agtcggtaag t                                                           11

<210>  8913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8913
cagtcggtaa gttctgtcca                                                  20

<210>  8914
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8914
cagtcggtaa gttctgtcc                                                   19

<210>  8915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8915
cagtcggtaa gttctgtc                                                    18

<210>  8916
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8916
cagtcggtaa gttctgt                                                     17

<210>  8917
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8917
cagtcggtaa gttctg                                                      16

<210>  8918
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8918
cagtcggtaa gttct                                                       15

<210>  8919
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8919
cagtcggtaa gttc                                                        14

<210>  8920
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8920
cagtcggtaa gtt                                                         13

<210>  8921
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8921
cagtcggtaa gt                                                          12

<210>  8922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8922
ccagtcggta agttctgtcc                                                  20

<210>  8923
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8923
ccagtcggta agttctgtc                                                   19

<210>  8924
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8924
ccagtcggta agttctgt                                                    18

<210>  8925
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8925
ccagtcggta agttctg                                                     17

<210>  8926
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8926
ccagtcggta agttct                                                      16

<210>  8927
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8927
ccagtcggta agttc                                                       15

<210>  8928
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8928
ccagtcggta agtt                                                        14

<210>  8929
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8929
ccagtcggta agt                                                         13

<210>  8930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8930
gccagtcggt aagttctgtc                                                  20

<210>  8931
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8931
gccagtcggt aagttctgt                                                   19

<210>  8932
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8932
gccagtcggt aagttctg                                                    18

<210>  8933
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8933
gccagtcggt aagttct                                                     17

<210>  8934
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8934
gccagtcggt aagttc                                                      16

<210>  8935
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8935
gccagtcggt aagtt                                                       15

<210>  8936
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8936
gccagtcggt aagt                                                        14

<210>  8937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8937
tcaaggaaga tggcatttct                                                  20

<210>  8938
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  8938
tcaaggaaga tggcatttct ag                                               22

<210>  8939
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8939
tcaaggaaga tggcat                                                      16

<210>  8940
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8940
gaagatggca tttct                                                       15

<210>  8941
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8941
tcaaggaaga tggcatttct a                                                21

<210>  8942
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8942
tcaaggaaga tggcatttc                                                   19

<210>  8943
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8943
tcaaggaaga tggcattt                                                    18

<210>  8944
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8944
tcaaggaaga tggcatt                                                     17

<210>  8945
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8945
tcaaggaaga tggca                                                       15

<210>  8946
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8946
tcaaggaaga tggc                                                        14

<210>  8947
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8947
tcaaggaaga tgg                                                         13

<210>  8948
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8948
tcaaggaaga tg                                                          12

<210>  8949
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8949
tcaaggaaga t                                                           11

<210>  8950
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8950
tcaaggaaga                                                             10

<210>  8951
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8951
tcaaggaag                                                              9

<210>  8952
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  8952
caaggaagat ggcatttcta g                                                21

<210>  8953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8953
caaggaagat ggcatttcta                                                  20

<210>  8954
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8954
caaggaagat ggcatttct                                                   19

<210>  8955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8955
caaggaagat ggcatttc                                                    18

<210>  8956
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8956
caaggaagat ggcattt                                                     17

<210>  8957
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8957
caaggaagat ggcatt                                                      16

<210>  8958
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8958
caaggaagat ggcat                                                       15

<210>  8959
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8959
caaggaagat ggca                                                        14

<210>  8960
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8960
caaggaagat ggc                                                         13

<210>  8961
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8961
caaggaagat gg                                                          12

<210>  8962
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8962
caaggaagat g                                                           11

<210>  8963
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8963
caaggaagat                                                             10

<210>  8964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  8964
aaggaagatg gcatttctag                                                  20

<210>  8965
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8965
aaggaagatg gcatttcta                                                   19

<210>  8966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8966
aaggaagatg gcatttct                                                    18

<210>  8967
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8967
aaggaagatg gcatttc                                                     17

<210>  8968
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8968
aaggaagatg gcattt                                                      16

<210>  8969
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8969
aaggaagatg gcatt                                                       15

<210>  8970
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8970
aaggaagatg gcat                                                        14

<210>  8971
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8971
aaggaagatg gca                                                         13

<210>  8972
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8972
aaggaagatg gc                                                          12

<210>  8973
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  8973
aggaagatgg catttctag                                                   19

<210>  8974
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8974
aggaagatgg catttcta                                                    18

<210>  8975
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8975
aggaagatgg catttct                                                     17

<210>  8976
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8976
aggaagatgg catttc                                                      16

<210>  8977
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8977
aggaagatgg cattt                                                       15

<210>  8978
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8978
aggaagatgg catt                                                        14

<210>  8979
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8979
aggaagatgg cat                                                         13

<210>  8980
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8980
aggaagatgg ca                                                          12

<210>  8981
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  8981
ggaagatggc atttctag                                                    18

<210>  8982
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8982
ggaagatggc atttcta                                                     17

<210>  8983
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8983
ggaagatggc atttct                                                      16

<210>  8984
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8984
ggaagatggc atttc                                                       15

<210>  8985
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8985
ggaagatggc attt                                                        14

<210>  8986
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8986
ggaagatggc att                                                         13

<210>  8987
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8987
ggaagatggc at                                                          12

<210>  8988
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8988
ggaagatggc a                                                           11

<210>  8989
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8989
ggaagatggc                                                             10

<210>  8990
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  8990
gaagatggca tttctag                                                     17

<210>  8991
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8991
gaagatggca tttcta                                                      16

<210>  8992
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  8992
gaagatggca tttc                                                        14

<210>  8993
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  8993
gaagatggca ttt                                                         13

<210>  8994
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  8994
gaagatggca tt                                                          12

<210>  8995
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  8995
gaagatggca t                                                           11

<210>  8996
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  8996
gaagatggca                                                             10

<210>  8997
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  8997
gaagatggc                                                              9

<210>  8998
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  8998
aagatggcat ttctag                                                      16

<210>  8999
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  8999
aagatggcat ttcta                                                       15

<210>  9000
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9000
aagatggcat ttct                                                        14

<210>  9001
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9001
aagatggcat ttc                                                         13

<210>  9002
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9002
aagatggcat tt                                                          12

<210>  9003
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9003
aagatggcat t                                                           11

<210>  9004
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9004
aagatggcat                                                             10

<210>  9005
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9005
aagatggca                                                              9

<210>  9006
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9006
aagatggc                                                               8

<210>  9007
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9007
agatggcatt tctag                                                       15

<210>  9008
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9008
agatggcatt tcta                                                        14

<210>  9009
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9009
agatggcatt tct                                                         13

<210>  9010
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9010
agatggcatt tc                                                          12

<210>  9011
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9011
agatggcatt t                                                           11

<210>  9012
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9012
agatggcatt                                                             10

<210>  9013
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9013
agatggcat                                                              9

<210>  9014
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9014
agatggca                                                               8

<210>  9015
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  9015
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  9016
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  9016
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  9017
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  9017
ctccaacatc aaggaagatg gcatttct                                         28

<210>  9018
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9018
ctccaacatc aaggaagatg gcatttc                                          27

<210>  9019
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9019
ctccaacatc aaggaagatg gcattt                                           26

<210>  9020
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9020
ctccaacatc aaggaagatg gcatt                                            25

<210>  9021
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9021
ctccaacatc aaggaagatg gcat                                             24

<210>  9022
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9022
ctccaacatc aaggaagatg gca                                              23

<210>  9023
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9023
ctccaacatc aaggaagatg gc                                               22

<210>  9024
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9024
ctccaacatc aaggaagatg g                                                21

<210>  9025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9025
ctccaacatc aaggaagatg                                                  20

<210>  9026
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9026
ctccaacatc aaggaagat                                                   19

<210>  9027
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9027
ctccaacatc aaggaaga                                                    18

<210>  9028
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9028
ctccaacatc aaggaag                                                     17

<210>  9029
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  9029
tccaacatca aggaagatgg catttctag                                        29

<210>  9030
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  9030
tccaacatca aggaagatgg catttcta                                         28

<210>  9031
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9031
tccaacatca aggaagatgg catttct                                          27

<210>  9032
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9032
tccaacatca aggaagatgg catttc                                           26

<210>  9033
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9033
tccaacatca aggaagatgg cattt                                            25

<210>  9034
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9034
tccaacatca aggaagatgg catt                                             24

<210>  9035
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9035
tccaacatca aggaagatgg cat                                              23

<210>  9036
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9036
tccaacatca aggaagatgg ca                                               22

<210>  9037
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9037
tccaacatca aggaagatgg c                                                21

<210>  9038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9038
tccaacatca aggaagatgg                                                  20

<210>  9039
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9039
tccaacatca aggaagatg                                                   19

<210>  9040
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9040
tccaacatca aggaagat                                                    18

<210>  9041
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9041
tccaacatca aggaaga                                                     17

<210>  9042
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9042
tccaacatca aggaag                                                      16

<210>  9043
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  9043
ccaacatcaa ggaagatggc atttctag                                         28

<210>  9044
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9044
ccaacatcaa ggaagatggc atttcta                                          27

<210>  9045
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9045
ccaacatcaa ggaagatggc atttct                                           26

<210>  9046
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9046
ccaacatcaa ggaagatggc atttc                                            25

<210>  9047
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9047
ccaacatcaa ggaagatggc attt                                             24

<210>  9048
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9048
ccaacatcaa ggaagatggc att                                              23

<210>  9049
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9049
ccaacatcaa ggaagatggc at                                               22

<210>  9050
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9050
ccaacatcaa ggaagatggc a                                                21

<210>  9051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9051
ccaacatcaa ggaagatggc                                                  20

<210>  9052
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9052
ccaacatcaa ggaagatgg                                                   19

<210>  9053
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9053
ccaacatcaa ggaagatg                                                    18

<210>  9054
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9054
ccaacatcaa ggaagat                                                     17

<210>  9055
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9055
ccaacatcaa ggaaga                                                      16

<210>  9056
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9056
ccaacatcaa ggaag                                                       15

<210>  9057
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9057
caacatcaag gaagatggca tttctag                                          27

<210>  9058
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9058
caacatcaag gaagatggca tttcta                                           26

<210>  9059
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9059
caacatcaag gaagatggca tttct                                            25

<210>  9060
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9060
caacatcaag gaagatggca tttc                                             24

<210>  9061
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9061
caacatcaag gaagatggca ttt                                              23

<210>  9062
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9062
caacatcaag gaagatggca tt                                               22

<210>  9063
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9063
caacatcaag gaagatggca t                                                21

<210>  9064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9064
caacatcaag gaagatggca                                                  20

<210>  9065
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9065
caacatcaag gaagatggc                                                   19

<210>  9066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9066
caacatcaag gaagatgg                                                    18

<210>  9067
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9067
caacatcaag gaagatg                                                     17

<210>  9068
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9068
caacatcaag gaagat                                                      16

<210>  9069
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9069
caacatcaag gaaga                                                       15

<210>  9070
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9070
caacatcaag gaag                                                        14

<210>  9071
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9071
aacatcaagg aagatggcat ttctag                                           26

<210>  9072
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9072
aacatcaagg aagatggcat ttcta                                            25

<210>  9073
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9073
aacatcaagg aagatggcat ttct                                             24

<210>  9074
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9074
aacatcaagg aagatggcat ttc                                              23

<210>  9075
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9075
aacatcaagg aagatggcat tt                                               22

<210>  9076
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9076
aacatcaagg aagatggcat t                                                21

<210>  9077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9077
aacatcaagg aagatggcat                                                  20

<210>  9078
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9078
aacatcaagg aagatggca                                                   19

<210>  9079
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9079
aacatcaagg aagatggc                                                    18

<210>  9080
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9080
aacatcaagg aagatgg                                                     17

<210>  9081
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9081
aacatcaagg aagatg                                                      16

<210>  9082
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9082
aacatcaagg aagat                                                       15

<210>  9083
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9083
aacatcaagg aaga                                                        14

<210>  9084
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9084
aacatcaagg aag                                                         13

<210>  9085
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9085
acatcaagga agatggcatt tctag                                            25

<210>  9086
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9086
acatcaagga agatggcatt tcta                                             24

<210>  9087
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9087
acatcaagga agatggcatt tct                                              23

<210>  9088
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9088
acatcaagga agatggcatt tc                                               22

<210>  9089
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9089
acatcaagga agatggcatt t                                                21

<210>  9090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9090
acatcaagga agatggcatt                                                  20

<210>  9091
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9091
acatcaagga agatggcat                                                   19

<210>  9092
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9092
acatcaagga agatggca                                                    18

<210>  9093
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9093
acatcaagga agatggc                                                     17

<210>  9094
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9094
acatcaagga agatgg                                                      16

<210>  9095
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9095
acatcaagga agatg                                                       15

<210>  9096
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9096
acatcaagga agat                                                        14

<210>  9097
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9097
acatcaagga aga                                                         13

<210>  9098
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9098
acatcaagga ag                                                          12

<210>  9099
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9099
catcaaggaa gatggcattt ctag                                             24

<210>  9100
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9100
catcaaggaa gatggcattt cta                                              23

<210>  9101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9101
catcaaggaa gatggcattt ct                                               22

<210>  9102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9102
catcaaggaa gatggcattt c                                                21

<210>  9103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9103
catcaaggaa gatggcattt                                                  20

<210>  9104
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9104
catcaaggaa gatggcatt                                                   19

<210>  9105
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9105
catcaaggaa gatggcat                                                    18

<210>  9106
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9106
catcaaggaa gatggca                                                     17

<210>  9107
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9107
catcaaggaa gatggc                                                      16

<210>  9108
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9108
catcaaggaa gatgg                                                       15

<210>  9109
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9109
catcaaggaa gatg                                                        14

<210>  9110
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9110
catcaaggaa gat                                                         13

<210>  9111
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9111
catcaaggaa ga                                                          12

<210>  9112
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9112
catcaaggaa g                                                           11

<210>  9113
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9113
atcaaggaag atggcatttc tag                                              23

<210>  9114
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9114
atcaaggaag atggcatttc ta                                               22

<210>  9115
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9115
atcaaggaag atggcatttc t                                                21

<210>  9116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9116
atcaaggaag atggcatttc                                                  20

<210>  9117
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9117
atcaaggaag atggcattt                                                   19

<210>  9118
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9118
atcaaggaag atggcatt                                                    18

<210>  9119
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9119
atcaaggaag atggcat                                                     17

<210>  9120
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9120
atcaaggaag atggca                                                      16

<210>  9121
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9121
atcaaggaag atggc                                                       15

<210>  9122
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9122
atcaaggaag atgg                                                        14

<210>  9123
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9123
atcaaggaag atg                                                         13

<210>  9124
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9124
atcaaggaag at                                                          12

<210>  9125
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9125
atcaaggaag a                                                           11

<210>  9126
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9126
atcaaggaag                                                             10

<210>  9127
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9127
ggtaagttct gtccaagc                                                    18

<210>  9128
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9128
gtaagttctg tccaagcc                                                    18

<210>  9129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9129
agtcggtaag ttctgtcc                                                    18

<210>  9130
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9130
ctgtccaagc ccggttga                                                    18

<210>  9131
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9131
taagttctgt ccaag                                                       15

<210>  9132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9132
ttctgtccaa gcccggttga                                                  20

<210>  9133
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9133
ttctgtccaa gcccggttg                                                   19

<210>  9134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9134
ttctgtccaa gcccggtt                                                    18

<210>  9135
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9135
ttctgtccaa gcccggt                                                     17

<210>  9136
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9136
ttctgtccaa gcccgg                                                      16

<210>  9137
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9137
ttctgtccaa gcccg                                                       15

<210>  9138
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9138
ttctgtccaa gccc                                                        14

<210>  9139
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9139
ttctgtccaa gcc                                                         13

<210>  9140
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9140
ttctgtccaa gc                                                          12

<210>  9141
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9141
ttctgtccaa g                                                           11

<210>  9142
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9142
ttctgtccaa                                                             10

<210>  9143
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9143
ttctgtcca                                                              9

<210>  9144
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9144
ttctgtcc                                                               8

<210>  9145
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9145
tctgtccaag cccggttga                                                   19

<210>  9146
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9146
tctgtccaag cccggttg                                                    18

<210>  9147
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9147
tctgtccaag cccggtt                                                     17

<210>  9148
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9148
tctgtccaag cccggt                                                      16

<210>  9149
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9149
tctgtccaag cccgg                                                       15

<210>  9150
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9150
tctgtccaag cccg                                                        14

<210>  9151
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9151
tctgtccaag ccc                                                         13

<210>  9152
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9152
tctgtccaag cc                                                          12

<210>  9153
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9153
tctgtccaag c                                                           11

<210>  9154
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  9154
tctgtccaag                                                             10

<210>  9155
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  9155
tctgtccaa                                                              9

<210>  9156
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  9156
tctgtcca                                                               8

<210>  9157
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9157
ctgtccaagc ccggttg                                                     17

<210>  9158
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9158
ctgtccaagc ccggtt                                                      16

<210>  9159
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9159
ctgtccaagc ccggt                                                       15

<210>  9160
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9160
ctgtccaagc ccgg                                                        14

<210>  9161
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9161
ctgtccaagc ccg                                                         13

<210>  9162
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9162
ctgtccaagc cc                                                          12

<210>  9163
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9163
ctgtccaagc c                                                           11

<210>  9164
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9164
ctgtccaagc                                                             10

<210>  9165
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9165
ctgtccaag                                                              9

<210>  9166
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9166
ctgtccaa                                                               8

<210>  9167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9167
gttctgtcca agcccggttg                                                  20

<210>  9168
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9168
gttctgtcca agcccggtt                                                   19

<210>  9169
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9169
gttctgtcca agcccggt                                                    18

<210>  9170
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9170
gttctgtcca agcccgg                                                     17

<210>  9171
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9171
gttctgtcca agcccg                                                      16

<210>  9172
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9172
gttctgtcca agccc                                                       15

<210>  9173
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9173
gttctgtcca agcc                                                        14

<210>  9174
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9174
gttctgtcca agc                                                         13

<210>  9175
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9175
gttctgtcca ag                                                          12

<210>  9176
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9176
gttctgtcca a                                                           11

<210>  9177
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9177
gttctgtcca                                                             10

<210>  9178
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9178
gttctgtcc                                                              9

<210>  9179
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9179
gttctgtc                                                               8

<210>  9180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9180
agttctgtcc aagcccggtt                                                  20

<210>  9181
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9181
agttctgtcc aagcccggt                                                   19

<210>  9182
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9182
agttctgtcc aagcccgg                                                    18

<210>  9183
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9183
agttctgtcc aagcccg                                                     17

<210>  9184
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9184
agttctgtcc aagccc                                                      16

<210>  9185
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  9185
agttctgtcc aagcc                                                       15

<210>  9186
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9186
agttctgtcc aagc                                                        14

<210>  9187
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9187
agttctgtcc aag                                                         13

<210>  9188
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9188
agttctgtcc aa                                                          12

<210>  9189
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9189
agttctgtcc a                                                           11

<210>  9190
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9190
agttctgtcc                                                             10

<210>  9191
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9191
agttctgtc                                                              9

<210>  9192
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9192
agttctgt                                                               8

<210>  9193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9193
aagttctgtc caagcccggt                                                  20

<210>  9194
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9194
aagttctgtc caagcccgg                                                   19

<210>  9195
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9195
aagttctgtc caagcccg                                                    18

<210>  9196
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9196
aagttctgtc caagccc                                                     17

<210>  9197
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9197
aagttctgtc caagcc                                                      16

<210>  9198
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9198
aagttctgtc caagc                                                       15

<210>  9199
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9199
aagttctgtc caag                                                        14

<210>  9200
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9200
aagttctgtc caa                                                         13

<210>  9201
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9201
aagttctgtc ca                                                          12

<210>  9202
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9202
aagttctgtc c                                                           11

<210>  9203
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9203
aagttctgtc                                                             10

<210>  9204
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9204
aagttctgt                                                              9

<210>  9205
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9205
aagttctg                                                               8

<210>  9206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  9206
taagttctgt ccaagcccgg                                                  20

<210>  9207
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  9207
taagttctgt ccaagcccg                                                   19

<210>  9208
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  9208
taagttctgt ccaagccc                                                    18

<210>  9209
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9209
taagttctgt ccaagcc                                                     17

<210>  9210
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9210
taagttctgt ccaagc                                                      16

<210>  9211
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9211
taagttctgt ccaa                                                        14

<210>  9212
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9212
taagttctgt cca                                                         13

<210>  9213
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9213
taagttctgt cc                                                          12

<210>  9214
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9214
taagttctgt c                                                           11

<210>  9215
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9215
taagttctgt                                                             10

<210>  9216
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9216
taagttctg                                                              9

<210>  9217
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9217
taagttct                                                               8

<210>  9218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  9218
gtaagttctg tccaagcccg                                                  20

<210>  9219
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  9219
gtaagttctg tccaagccc                                                   19

<210>  9220
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9220
gtaagttctg tccaagc                                                     17

<210>  9221
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9221
gtaagttctg tccaag                                                      16

<210>  9222
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9222
gtaagttctg tccaa                                                       15

<210>  9223
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9223
gtaagttctg tcca                                                        14

<210>  9224
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9224
gtaagttctg tcc                                                         13

<210>  9225
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9225
gtaagttctg tc                                                          12

<210>  9226
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9226
gtaagttctg t                                                           11

<210>  9227
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9227
gtaagttctg                                                             10

<210>  9228
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9228
gtaagttct                                                              9

<210>  9229
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9229
gtaagttc                                                               8

<210>  9230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  9230
ggtaagttct gtccaagccc                                                  20

<210>  9231
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  9231
ggtaagttct gtccaagcc                                                   19

<210>  9232
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9232
ggtaagttct gtccaag                                                     17

<210>  9233
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9233
ggtaagttct gtccaa                                                      16

<210>  9234
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9234
ggtaagttct gtcca                                                       15

<210>  9235
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9235
ggtaagttct gtcc                                                        14

<210>  9236
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9236
ggtaagttct gtc                                                         13

<210>  9237
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9237
ggtaagttct gt                                                          12

<210>  9238
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9238
ggtaagttct g                                                           11

<210>  9239
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9239
ggtaagttct                                                             10

<210>  9240
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9240
ggtaagttc                                                              9

<210>  9241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9241
cggtaagttc tgtccaagcc                                                  20

<210>  9242
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9242
cggtaagttc tgtccaagc                                                   19

<210>  9243
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9243
cggtaagttc tgtccaag                                                    18

<210>  9244
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9244
cggtaagttc tgtccaa                                                     17

<210>  9245
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9245
cggtaagttc tgtcca                                                      16

<210>  9246
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9246
cggtaagttc tgtcc                                                       15

<210>  9247
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9247
cggtaagttc tgtc                                                        14

<210>  9248
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9248
cggtaagttc tgt                                                         13

<210>  9249
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9249
cggtaagttc tg                                                          12

<210>  9250
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9250
cggtaagttc t                                                           11

<210>  9251
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9251
cggtaagttc                                                             10

<210>  9252
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9252
cggtaagtt                                                              9

<210>  9253
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9253
cggtaagt                                                               8

<210>  9254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9254
tcggtaagtt ctgtccaagc                                                  20

<210>  9255
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9255
tcggtaagtt ctgtccaag                                                   19

<210>  9256
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9256
tcggtaagtt ctgtccaa                                                    18

<210>  9257
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9257
tcggtaagtt ctgtcca                                                     17

<210>  9258
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9258
tcggtaagtt ctgtcc                                                      16

<210>  9259
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9259
tcggtaagtt ctgtc                                                       15

<210>  9260
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9260
tcggtaagtt ctgt                                                        14

<210>  9261
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9261
tcggtaagtt ctg                                                         13

<210>  9262
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9262
tcggtaagtt ct                                                          12

<210>  9263
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9263
tcggtaagtt c                                                           11

<210>  9264
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9264
tcggtaagtt                                                             10

<210>  9265
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9265
tcggtaagt                                                              9

<210>  9266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9266
gtcggtaagt tctgtccaag                                                  20

<210>  9267
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9267
gtcggtaagt tctgtccaa                                                   19

<210>  9268
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9268
gtcggtaagt tctgtcca                                                    18

<210>  9269
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9269
gtcggtaagt tctgtcc                                                     17

<210>  9270
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9270
gtcggtaagt tctgtc                                                      16

<210>  9271
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9271
gtcggtaagt tctgt                                                       15

<210>  9272
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9272
gtcggtaagt tctg                                                        14

<210>  9273
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9273
gtcggtaagt tct                                                         13

<210>  9274
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9274
gtcggtaagt tc                                                          12

<210>  9275
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9275
gtcggtaagt t                                                           11

<210>  9276
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9276
gtcggtaagt                                                             10

<210>  9277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9277
agtcggtaag ttctgtccaa                                                  20

<210>  9278
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9278
agtcggtaag ttctgtcca                                                   19

<210>  9279
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9279
agtcggtaag ttctgtc                                                     17

<210>  9280
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9280
agtcggtaag ttctgt                                                      16

<210>  9281
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9281
agtcggtaag ttctg                                                       15

<210>  9282
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9282
agtcggtaag ttct                                                        14

<210>  9283
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9283
agtcggtaag ttc                                                         13

<210>  9284
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  9284
agtcggtaag tt                                                          12

<210>  9285
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  9285
agtcggtaag t                                                           11

<210>  9286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9286
cagtcggtaa gttctgtcca                                                  20

<210>  9287
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9287
cagtcggtaa gttctgtcc                                                   19

<210>  9288
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9288
cagtcggtaa gttctgtc                                                    18

<210>  9289
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9289
cagtcggtaa gttctgt                                                     17

<210>  9290
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9290
cagtcggtaa gttctg                                                      16

<210>  9291
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9291
cagtcggtaa gttct                                                       15

<210>  9292
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9292
cagtcggtaa gttc                                                        14

<210>  9293
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9293
cagtcggtaa gtt                                                         13

<210>  9294
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9294
cagtcggtaa gt                                                          12

<210>  9295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9295
ccagtcggta agttctgtcc                                                  20

<210>  9296
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9296
ccagtcggta agttctgtc                                                   19

<210>  9297
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9297
ccagtcggta agttctgt                                                    18

<210>  9298
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9298
ccagtcggta agttctg                                                     17

<210>  9299
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9299
ccagtcggta agttct                                                      16

<210>  9300
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9300
ccagtcggta agttc                                                       15

<210>  9301
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9301
ccagtcggta agtt                                                        14

<210>  9302
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9302
ccagtcggta agt                                                         13

<210>  9303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9303
gccagtcggt aagttctgtc                                                  20

<210>  9304
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9304
gccagtcggt aagttctgt                                                   19

<210>  9305
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9305
gccagtcggt aagttctg                                                    18

<210>  9306
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9306
gccagtcggt aagttct                                                     17

<210>  9307
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9307
gccagtcggt aagttc                                                      16

<210>  9308
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9308
gccagtcggt aagtt                                                       15

<210>  9309
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9309
gccagtcggt aagt                                                        14

<210>  9310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9310
tcaaggaaga tggcatttct                                                  20

<210>  9311
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9311
tcaaggaaga tggcatttct ag                                               22

<210>  9312
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9312
tcaaggaaga tggcat                                                      16

<210>  9313
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9313
gaagatggca tttct                                                       15

<210>  9314
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9314
tcaaggaaga tggcatttct a                                                21

<210>  9315
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9315
tcaaggaaga tggcatttc                                                   19

<210>  9316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9316
tcaaggaaga tggcattt                                                    18

<210>  9317
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9317
tcaaggaaga tggcatt                                                     17

<210>  9318
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9318
tcaaggaaga tggca                                                       15

<210>  9319
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9319
tcaaggaaga tggc                                                        14

<210>  9320
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9320
tcaaggaaga tgg                                                         13

<210>  9321
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9321
tcaaggaaga tg                                                          12

<210>  9322
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9322
tcaaggaaga t                                                           11

<210>  9323
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9323
tcaaggaaga                                                             10

<210>  9324
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9324
tcaaggaag                                                              9

<210>  9325
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9325
caaggaagat ggcatttcta g                                                21

<210>  9326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9326
caaggaagat ggcatttcta                                                  20

<210>  9327
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9327
caaggaagat ggcatttct                                                   19

<210>  9328
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9328
caaggaagat ggcatttc                                                    18

<210>  9329
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9329
caaggaagat ggcattt                                                     17

<210>  9330
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9330
caaggaagat ggcatt                                                      16

<210>  9331
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9331
caaggaagat ggcat                                                       15

<210>  9332
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9332
caaggaagat ggca                                                        14

<210>  9333
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9333
caaggaagat ggc                                                         13

<210>  9334
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9334
caaggaagat gg                                                          12

<210>  9335
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9335
caaggaagat g                                                           11

<210>  9336
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9336
caaggaagat                                                             10

<210>  9337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9337
aaggaagatg gcatttctag                                                  20

<210>  9338
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9338
aaggaagatg gcatttcta                                                   19

<210>  9339
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9339
aaggaagatg gcatttct                                                    18

<210>  9340
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9340
aaggaagatg gcatttc                                                     17

<210>  9341
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9341
aaggaagatg gcattt                                                      16

<210>  9342
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9342
aaggaagatg gcatt                                                       15

<210>  9343
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9343
aaggaagatg gcat                                                        14

<210>  9344
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9344
aaggaagatg gca                                                         13

<210>  9345
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9345
aaggaagatg gc                                                          12

<210>  9346
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9346
aggaagatgg catttctag                                                   19

<210>  9347
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9347
aggaagatgg catttcta                                                    18

<210>  9348
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9348
aggaagatgg catttct                                                     17

<210>  9349
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9349
aggaagatgg catttc                                                      16

<210>  9350
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9350
aggaagatgg cattt                                                       15

<210>  9351
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9351
aggaagatgg catt                                                        14

<210>  9352
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9352
aggaagatgg cat                                                         13

<210>  9353
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9353
aggaagatgg ca                                                          12

<210>  9354
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9354
ggaagatggc atttctag                                                    18

<210>  9355
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9355
ggaagatggc atttcta                                                     17

<210>  9356
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9356
ggaagatggc atttct                                                      16

<210>  9357
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9357
ggaagatggc atttc                                                       15

<210>  9358
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9358
ggaagatggc attt                                                        14

<210>  9359
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9359
ggaagatggc att                                                         13

<210>  9360
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9360
ggaagatggc at                                                          12

<210>  9361
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9361
ggaagatggc a                                                           11

<210>  9362
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9362
ggaagatggc                                                             10

<210>  9363
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9363
gaagatggca tttctag                                                     17

<210>  9364
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9364
gaagatggca tttcta                                                      16

<210>  9365
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9365
gaagatggca tttc                                                        14

<210>  9366
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9366
gaagatggca ttt                                                         13

<210>  9367
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9367
gaagatggca tt                                                          12

<210>  9368
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9368
gaagatggca t                                                           11

<210>  9369
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9369
gaagatggca                                                             10

<210>  9370
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9370
gaagatggc                                                              9

<210>  9371
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9371
aagatggcat ttctag                                                      16

<210>  9372
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9372
aagatggcat ttcta                                                       15

<210>  9373
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9373
aagatggcat ttct                                                        14

<210>  9374
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9374
aagatggcat ttc                                                         13

<210>  9375
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9375
aagatggcat tt                                                          12

<210>  9376
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9376
aagatggcat t                                                           11

<210>  9377
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9377
aagatggcat                                                             10

<210>  9378
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9378
aagatggca                                                              9

<210>  9379
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9379
aagatggc                                                               8

<210>  9380
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9380
agatggcatt tctag                                                       15

<210>  9381
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9381
agatggcatt tcta                                                        14

<210>  9382
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9382
agatggcatt tct                                                         13

<210>  9383
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9383
agatggcatt tc                                                          12

<210>  9384
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9384
agatggcatt t                                                           11

<210>  9385
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9385
agatggcatt                                                             10

<210>  9386
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9386
agatggcat                                                              9

<210>  9387
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9387
agatggca                                                               8

<210>  9388
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  9388
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  9389
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  9389
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  9390
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  9390
ctccaacatc aaggaagatg gcatttct                                         28

<210>  9391
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9391
ctccaacatc aaggaagatg gcatttc                                          27

<210>  9392
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9392
ctccaacatc aaggaagatg gcattt                                           26

<210>  9393
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9393
ctccaacatc aaggaagatg gcatt                                            25

<210>  9394
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9394
ctccaacatc aaggaagatg gcat                                             24

<210>  9395
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9395
ctccaacatc aaggaagatg gca                                              23

<210>  9396
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9396
ctccaacatc aaggaagatg gc                                               22

<210>  9397
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9397
ctccaacatc aaggaagatg g                                                21

<210>  9398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9398
ctccaacatc aaggaagatg                                                  20

<210>  9399
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9399
ctccaacatc aaggaagat                                                   19

<210>  9400
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9400
ctccaacatc aaggaaga                                                    18

<210>  9401
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9401
ctccaacatc aaggaag                                                     17

<210>  9402
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9402
tccaacatca aggaagatgg catttctag                                        29

<210>  9403
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9403
tccaacatca aggaagatgg catttcta                                         28

<210>  9404
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9404
tccaacatca aggaagatgg catttct                                          27

<210>  9405
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9405
tccaacatca aggaagatgg catttc                                           26

<210>  9406
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9406
tccaacatca aggaagatgg cattt                                            25

<210>  9407
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9407
tccaacatca aggaagatgg catt                                             24

<210>  9408
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9408
tccaacatca aggaagatgg cat                                              23

<210>  9409
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9409
tccaacatca aggaagatgg ca                                               22

<210>  9410
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9410
tccaacatca aggaagatgg c                                                21

<210>  9411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9411
tccaacatca aggaagatgg                                                  20

<210>  9412
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9412
tccaacatca aggaagatg                                                   19

<210>  9413
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9413
tccaacatca aggaagat                                                    18

<210>  9414
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9414
tccaacatca aggaaga                                                     17

<210>  9415
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9415
tccaacatca aggaag                                                      16

<210>  9416
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  9416
ccaacatcaa ggaagatggc atttctag                                         28

<210>  9417
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9417
ccaacatcaa ggaagatggc atttcta                                          27

<210>  9418
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9418
ccaacatcaa ggaagatggc atttct                                           26

<210>  9419
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9419
ccaacatcaa ggaagatggc atttc                                            25

<210>  9420
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9420
ccaacatcaa ggaagatggc attt                                             24

<210>  9421
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9421
ccaacatcaa ggaagatggc att                                              23

<210>  9422
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9422
ccaacatcaa ggaagatggc at                                               22

<210>  9423
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9423
ccaacatcaa ggaagatggc a                                                21

<210>  9424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9424
ccaacatcaa ggaagatggc                                                  20

<210>  9425
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9425
ccaacatcaa ggaagatgg                                                   19

<210>  9426
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9426
ccaacatcaa ggaagatg                                                    18

<210>  9427
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9427
ccaacatcaa ggaagat                                                     17

<210>  9428
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9428
ccaacatcaa ggaaga                                                      16

<210>  9429
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9429
ccaacatcaa ggaag                                                       15

<210>  9430
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  9430
caacatcaag gaagatggca tttctag                                          27

<210>  9431
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  9431
caacatcaag gaagatggca tttcta                                           26

<210>  9432
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  9432
caacatcaag gaagatggca tttct                                            25

<210>  9433
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9433
caacatcaag gaagatggca tttc                                             24

<210>  9434
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9434
caacatcaag gaagatggca ttt                                              23

<210>  9435
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9435
caacatcaag gaagatggca tt                                               22

<210>  9436
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9436
caacatcaag gaagatggca t                                                21

<210>  9437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9437
caacatcaag gaagatggca                                                  20

<210>  9438
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9438
caacatcaag gaagatggc                                                   19

<210>  9439
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9439
caacatcaag gaagatgg                                                    18

<210>  9440
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9440
caacatcaag gaagatg                                                     17

<210>  9441
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9441
caacatcaag gaagat                                                      16

<210>  9442
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9442
caacatcaag gaaga                                                       15

<210>  9443
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9443
caacatcaag gaag                                                        14

<210>  9444
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9444
aacatcaagg aagatggcat ttctag                                           26

<210>  9445
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9445
aacatcaagg aagatggcat ttcta                                            25

<210>  9446
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9446
aacatcaagg aagatggcat ttct                                             24

<210>  9447
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9447
aacatcaagg aagatggcat ttc                                              23

<210>  9448
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9448
aacatcaagg aagatggcat tt                                               22

<210>  9449
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9449
aacatcaagg aagatggcat t                                                21

<210>  9450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9450
aacatcaagg aagatggcat                                                  20

<210>  9451
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9451
aacatcaagg aagatggca                                                   19

<210>  9452
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9452
aacatcaagg aagatggc                                                    18

<210>  9453
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9453
aacatcaagg aagatgg                                                     17

<210>  9454
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9454
aacatcaagg aagatg                                                      16

<210>  9455
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9455
aacatcaagg aagat                                                       15

<210>  9456
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9456
aacatcaagg aaga                                                        14

<210>  9457
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9457
aacatcaagg aag                                                         13

<210>  9458
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9458
acatcaagga agatggcatt tctag                                            25

<210>  9459
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9459
acatcaagga agatggcatt tcta                                             24

<210>  9460
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9460
acatcaagga agatggcatt tct                                              23

<210>  9461
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9461
acatcaagga agatggcatt tc                                               22

<210>  9462
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9462
acatcaagga agatggcatt t                                                21

<210>  9463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9463
acatcaagga agatggcatt                                                  20

<210>  9464
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9464
acatcaagga agatggcat                                                   19

<210>  9465
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9465
acatcaagga agatggca                                                    18

<210>  9466
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9466
acatcaagga agatggc                                                     17

<210>  9467
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9467
acatcaagga agatgg                                                      16

<210>  9468
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9468
acatcaagga agatg                                                       15

<210>  9469
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9469
acatcaagga agat                                                        14

<210>  9470
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9470
acatcaagga aga                                                         13

<210>  9471
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9471
acatcaagga ag                                                          12

<210>  9472
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  9472
catcaaggaa gatggcattt ctag                                             24

<210>  9473
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  9473
catcaaggaa gatggcattt cta                                              23

<210>  9474
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  9474
catcaaggaa gatggcattt ct                                               22

<210>  9475
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  9475
catcaaggaa gatggcattt c                                                21

<210>  9476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9476
catcaaggaa gatggcattt                                                  20

<210>  9477
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9477
catcaaggaa gatggcatt                                                   19

<210>  9478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9478
catcaaggaa gatggcat                                                    18

<210>  9479
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9479
catcaaggaa gatggca                                                     17

<210>  9480
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9480
catcaaggaa gatggc                                                      16

<210>  9481
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9481
catcaaggaa gatgg                                                       15

<210>  9482
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9482
catcaaggaa gatg                                                        14

<210>  9483
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9483
catcaaggaa gat                                                         13

<210>  9484
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9484
catcaaggaa ga                                                          12

<210>  9485
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9485
catcaaggaa g                                                           11

<210>  9486
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9486
atcaaggaag atggcatttc tag                                              23

<210>  9487
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9487
atcaaggaag atggcatttc ta                                               22

<210>  9488
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9488
atcaaggaag atggcatttc t                                                21

<210>  9489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9489
atcaaggaag atggcatttc                                                  20

<210>  9490
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9490
atcaaggaag atggcattt                                                   19

<210>  9491
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9491
atcaaggaag atggcatt                                                    18

<210>  9492
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9492
atcaaggaag atggcat                                                     17

<210>  9493
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9493
atcaaggaag atggca                                                      16

<210>  9494
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9494
atcaaggaag atggc                                                       15

<210>  9495
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9495
atcaaggaag atgg                                                        14

<210>  9496
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9496
atcaaggaag atg                                                         13

<210>  9497
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9497
atcaaggaag at                                                          12

<210>  9498
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9498
atcaaggaag a                                                           11

<210>  9499
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9499
atcaaggaag                                                             10

<210>  9500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9500
ggtaagttct gtccaagc                                                    18

<210>  9501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9501
gtaagttctg tccaagcc                                                    18

<210>  9502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9502
agtcggtaag ttctgtcc                                                    18

<210>  9503
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9503
ctgtccaagc ccggttga                                                    18

<210>  9504
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9504
taagttctgt ccaag                                                       15

<210>  9505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9505
ttctgtccaa gcccggttga                                                  20

<210>  9506
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9506
ttctgtccaa gcccggttg                                                   19

<210>  9507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9507
ttctgtccaa gcccggtt                                                    18

<210>  9508
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9508
ttctgtccaa gcccggt                                                     17

<210>  9509
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9509
ttctgtccaa gcccgg                                                      16

<210>  9510
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9510
ttctgtccaa gcccg                                                       15

<210>  9511
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  9511
ttctgtccaa gccc                                                        14

<210>  9512
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9512
ttctgtccaa gcc                                                         13

<210>  9513
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9513
ttctgtccaa gc                                                          12

<210>  9514
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9514
ttctgtccaa g                                                           11

<210>  9515
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9515
ttctgtccaa                                                             10

<210>  9516
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9516
ttctgtcca                                                              9

<210>  9517
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  9517
ttctgtcc                                                               8

<210>  9518
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9518
tctgtccaag cccggttga                                                   19

<210>  9519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9519
tctgtccaag cccggttg                                                    18

<210>  9520
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9520
tctgtccaag cccggtt                                                     17

<210>  9521
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9521
tctgtccaag cccggt                                                      16

<210>  9522
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9522
tctgtccaag cccgg                                                       15

<210>  9523
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9523
tctgtccaag cccg                                                        14

<210>  9524
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  9524
tctgtccaag ccc                                                         13

<210>  9525
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9525
tctgtccaag cc                                                          12

<210>  9526
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9526
tctgtccaag c                                                           11

<210>  9527
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  9527
tctgtccaag                                                             10

<210>  9528
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  9528
tctgtccaa                                                              9

<210>  9529
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  9529
tctgtcca                                                               8

<210>  9530
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9530
ctgtccaagc ccggttg                                                     17

<210>  9531
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9531
ctgtccaagc ccggtt                                                      16

<210>  9532
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9532
ctgtccaagc ccggt                                                       15

<210>  9533
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9533
ctgtccaagc ccgg                                                        14

<210>  9534
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9534
ctgtccaagc ccg                                                         13

<210>  9535
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9535
ctgtccaagc cc                                                          12

<210>  9536
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9536
ctgtccaagc c                                                           11

<210>  9537
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9537
ctgtccaagc                                                             10

<210>  9538
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9538
ctgtccaag                                                              9

<210>  9539
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9539
ctgtccaa                                                               8

<210>  9540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9540
gttctgtcca agcccggttg                                                  20

<210>  9541
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9541
gttctgtcca agcccggtt                                                   19

<210>  9542
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9542
gttctgtcca agcccggt                                                    18

<210>  9543
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9543
gttctgtcca agcccgg                                                     17

<210>  9544
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9544
gttctgtcca agcccg                                                      16

<210>  9545
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  9545
gttctgtcca agccc                                                       15

<210>  9546
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9546
gttctgtcca agcc                                                        14

<210>  9547
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9547
gttctgtcca agc                                                         13

<210>  9548
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9548
gttctgtcca ag                                                          12

<210>  9549
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9549
gttctgtcca a                                                           11

<210>  9550
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9550
gttctgtcca                                                             10

<210>  9551
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  9551
gttctgtcc                                                              9

<210>  9552
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9552
gttctgtc                                                               8

<210>  9553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9553
agttctgtcc aagcccggtt                                                  20

<210>  9554
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9554
agttctgtcc aagcccggt                                                   19

<210>  9555
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9555
agttctgtcc aagcccgg                                                    18

<210>  9556
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9556
agttctgtcc aagcccg                                                     17

<210>  9557
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  9557
agttctgtcc aagccc                                                      16

<210>  9558
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  9558
agttctgtcc aagcc                                                       15

<210>  9559
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9559
agttctgtcc aagc                                                        14

<210>  9560
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9560
agttctgtcc aag                                                         13

<210>  9561
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9561
agttctgtcc aa                                                          12

<210>  9562
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9562
agttctgtcc a                                                           11

<210>  9563
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  9563
agttctgtcc                                                             10

<210>  9564
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9564
agttctgtc                                                              9

<210>  9565
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9565
agttctgt                                                               8

<210>  9566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9566
aagttctgtc caagcccggt                                                  20

<210>  9567
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9567
aagttctgtc caagcccgg                                                   19

<210>  9568
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9568
aagttctgtc caagcccg                                                    18

<210>  9569
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  9569
aagttctgtc caagccc                                                     17

<210>  9570
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9570
aagttctgtc caagcc                                                      16

<210>  9571
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9571
aagttctgtc caagc                                                       15

<210>  9572
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9572
aagttctgtc caag                                                        14

<210>  9573
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9573
aagttctgtc caa                                                         13

<210>  9574
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9574
aagttctgtc ca                                                          12

<210>  9575
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  9575
aagttctgtc c                                                           11

<210>  9576
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9576
aagttctgtc                                                             10

<210>  9577
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9577
aagttctgt                                                              9

<210>  9578
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9578
aagttctg                                                               8

<210>  9579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  9579
taagttctgt ccaagcccgg                                                  20

<210>  9580
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  9580
taagttctgt ccaagcccg                                                   19

<210>  9581
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  9581
taagttctgt ccaagccc                                                    18

<210>  9582
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9582
taagttctgt ccaagcc                                                     17

<210>  9583
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9583
taagttctgt ccaagc                                                      16

<210>  9584
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9584
taagttctgt ccaa                                                        14

<210>  9585
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9585
taagttctgt cca                                                         13

<210>  9586
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  9586
taagttctgt cc                                                          12

<210>  9587
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9587
taagttctgt c                                                           11

<210>  9588
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9588
taagttctgt                                                             10

<210>  9589
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9589
taagttctg                                                              9

<210>  9590
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9590
taagttct                                                               8

<210>  9591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  9591
gtaagttctg tccaagcccg                                                  20

<210>  9592
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  9592
gtaagttctg tccaagccc                                                   19

<210>  9593
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9593
gtaagttctg tccaagc                                                     17

<210>  9594
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9594
gtaagttctg tccaag                                                      16

<210>  9595
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9595
gtaagttctg tccaa                                                       15

<210>  9596
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9596
gtaagttctg tcca                                                        14

<210>  9597
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  9597
gtaagttctg tcc                                                         13

<210>  9598
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9598
gtaagttctg tc                                                          12

<210>  9599
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9599
gtaagttctg t                                                           11

<210>  9600
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9600
gtaagttctg                                                             10

<210>  9601
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9601
gtaagttct                                                              9

<210>  9602
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9602
gtaagttc                                                               8

<210>  9603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  9603
ggtaagttct gtccaagccc                                                  20

<210>  9604
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  9604
ggtaagttct gtccaagcc                                                   19

<210>  9605
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9605
ggtaagttct gtccaag                                                     17

<210>  9606
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9606
ggtaagttct gtccaa                                                      16

<210>  9607
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9607
ggtaagttct gtcca                                                       15

<210>  9608
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  9608
ggtaagttct gtcc                                                        14

<210>  9609
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9609
ggtaagttct gtc                                                         13

<210>  9610
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9610
ggtaagttct gt                                                          12

<210>  9611
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9611
ggtaagttct g                                                           11

<210>  9612
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9612
ggtaagttct                                                             10

<210>  9613
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9613
ggtaagttc                                                              9

<210>  9614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9614
cggtaagttc tgtccaagcc                                                  20

<210>  9615
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9615
cggtaagttc tgtccaagc                                                   19

<210>  9616
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9616
cggtaagttc tgtccaag                                                    18

<210>  9617
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9617
cggtaagttc tgtccaa                                                     17

<210>  9618
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9618
cggtaagttc tgtcca                                                      16

<210>  9619
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9619
cggtaagttc tgtcc                                                       15

<210>  9620
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9620
cggtaagttc tgtc                                                        14

<210>  9621
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9621
cggtaagttc tgt                                                         13

<210>  9622
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9622
cggtaagttc tg                                                          12

<210>  9623
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9623
cggtaagttc t                                                           11

<210>  9624
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9624
cggtaagttc                                                             10

<210>  9625
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9625
cggtaagtt                                                              9

<210>  9626
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9626
cggtaagt                                                               8

<210>  9627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9627
tcggtaagtt ctgtccaagc                                                  20

<210>  9628
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9628
tcggtaagtt ctgtccaag                                                   19

<210>  9629
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9629
tcggtaagtt ctgtccaa                                                    18

<210>  9630
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9630
tcggtaagtt ctgtcca                                                     17

<210>  9631
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  9631
tcggtaagtt ctgtcc                                                      16

<210>  9632
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9632
tcggtaagtt ctgtc                                                       15

<210>  9633
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9633
tcggtaagtt ctgt                                                        14

<210>  9634
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9634
tcggtaagtt ctg                                                         13

<210>  9635
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9635
tcggtaagtt ct                                                          12

<210>  9636
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9636
tcggtaagtt c                                                           11

<210>  9637
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9637
tcggtaagtt                                                             10

<210>  9638
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9638
tcggtaagt                                                              9

<210>  9639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9639
gtcggtaagt tctgtccaag                                                  20

<210>  9640
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9640
gtcggtaagt tctgtccaa                                                   19

<210>  9641
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9641
gtcggtaagt tctgtcca                                                    18

<210>  9642
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  9642
gtcggtaagt tctgtcc                                                     17

<210>  9643
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9643
gtcggtaagt tctgtc                                                      16

<210>  9644
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9644
gtcggtaagt tctgt                                                       15

<210>  9645
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9645
gtcggtaagt tctg                                                        14

<210>  9646
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9646
gtcggtaagt tct                                                         13

<210>  9647
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9647
gtcggtaagt tc                                                          12

<210>  9648
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9648
gtcggtaagt t                                                           11

<210>  9649
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9649
gtcggtaagt                                                             10

<210>  9650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9650
agtcggtaag ttctgtccaa                                                  20

<210>  9651
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  9651
agtcggtaag ttctgtcca                                                   19

<210>  9652
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9652
agtcggtaag ttctgtc                                                     17

<210>  9653
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9653
agtcggtaag ttctgt                                                      16

<210>  9654
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9654
agtcggtaag ttctg                                                       15

<210>  9655
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9655
agtcggtaag ttct                                                        14

<210>  9656
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9656
agtcggtaag ttc                                                         13

<210>  9657
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  9657
agtcggtaag tt                                                          12

<210>  9658
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  9658
agtcggtaag t                                                           11

<210>  9659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9659
cagtcggtaa gttctgtcca                                                  20

<210>  9660
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9660
cagtcggtaa gttctgtcc                                                   19

<210>  9661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9661
cagtcggtaa gttctgtc                                                    18

<210>  9662
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9662
cagtcggtaa gttctgt                                                     17

<210>  9663
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9663
cagtcggtaa gttctg                                                      16

<210>  9664
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9664
cagtcggtaa gttct                                                       15

<210>  9665
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9665
cagtcggtaa gttc                                                        14

<210>  9666
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9666
cagtcggtaa gtt                                                         13

<210>  9667
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9667
cagtcggtaa gt                                                          12

<210>  9668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9668
ccagtcggta agttctgtcc                                                  20

<210>  9669
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9669
ccagtcggta agttctgtc                                                   19

<210>  9670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9670
ccagtcggta agttctgt                                                    18

<210>  9671
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9671
ccagtcggta agttctg                                                     17

<210>  9672
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9672
ccagtcggta agttct                                                      16

<210>  9673
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9673
ccagtcggta agttc                                                       15

<210>  9674
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9674
ccagtcggta agtt                                                        14

<210>  9675
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9675
ccagtcggta agt                                                         13

<210>  9676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9676
gccagtcggt aagttctgtc                                                  20

<210>  9677
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9677
gccagtcggt aagttctgt                                                   19

<210>  9678
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9678
gccagtcggt aagttctg                                                    18

<210>  9679
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9679
gccagtcggt aagttct                                                     17

<210>  9680
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9680
gccagtcggt aagttc                                                      16

<210>  9681
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9681
gccagtcggt aagtt                                                       15

<210>  9682
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9682
gccagtcggt aagt                                                        14

<210>  9683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9683
tcaaggaaga tggcatttct                                                  20

<210>  9684
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9684
tcaaggaaga tggcatttct ag                                               22

<210>  9685
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9685
tcaaggaaga tggcat                                                      16

<210>  9686
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9686
gaagatggca tttct                                                       15

<210>  9687
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9687
tcaaggaaga tggcatttct a                                                21

<210>  9688
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  9688
tcaaggaaga tggcatttc                                                   19

<210>  9689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9689
tcaaggaaga tggcattt                                                    18

<210>  9690
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9690
tcaaggaaga tggcatt                                                     17

<210>  9691
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9691
tcaaggaaga tggca                                                       15

<210>  9692
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9692
tcaaggaaga tggc                                                        14

<210>  9693
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9693
tcaaggaaga tgg                                                         13

<210>  9694
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9694
tcaaggaaga tg                                                          12

<210>  9695
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9695
tcaaggaaga t                                                           11

<210>  9696
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9696
tcaaggaaga                                                             10

<210>  9697
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  9697
tcaaggaag                                                              9

<210>  9698
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9698
caaggaagat ggcatttcta g                                                21

<210>  9699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9699
caaggaagat ggcatttcta                                                  20

<210>  9700
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9700
caaggaagat ggcatttct                                                   19

<210>  9701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9701
caaggaagat ggcatttc                                                    18

<210>  9702
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9702
caaggaagat ggcattt                                                     17

<210>  9703
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9703
caaggaagat ggcatt                                                      16

<210>  9704
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9704
caaggaagat ggcat                                                       15

<210>  9705
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9705
caaggaagat ggca                                                        14

<210>  9706
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9706
caaggaagat ggc                                                         13

<210>  9707
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9707
caaggaagat gg                                                          12

<210>  9708
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9708
caaggaagat g                                                           11

<210>  9709
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9709
caaggaagat                                                             10

<210>  9710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9710
aaggaagatg gcatttctag                                                  20

<210>  9711
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9711
aaggaagatg gcatttcta                                                   19

<210>  9712
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9712
aaggaagatg gcatttct                                                    18

<210>  9713
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9713
aaggaagatg gcatttc                                                     17

<210>  9714
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9714
aaggaagatg gcattt                                                      16

<210>  9715
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9715
aaggaagatg gcatt                                                       15

<210>  9716
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9716
aaggaagatg gcat                                                        14

<210>  9717
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9717
aaggaagatg gca                                                         13

<210>  9718
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9718
aaggaagatg gc                                                          12

<210>  9719
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9719
aggaagatgg catttctag                                                   19

<210>  9720
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9720
aggaagatgg catttcta                                                    18

<210>  9721
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9721
aggaagatgg catttct                                                     17

<210>  9722
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  9722
aggaagatgg catttc                                                      16

<210>  9723
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9723
aggaagatgg cattt                                                       15

<210>  9724
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9724
aggaagatgg catt                                                        14

<210>  9725
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9725
aggaagatgg cat                                                         13

<210>  9726
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  9726
aggaagatgg ca                                                          12

<210>  9727
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9727
ggaagatggc atttctag                                                    18

<210>  9728
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9728
ggaagatggc atttcta                                                     17

<210>  9729
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9729
ggaagatggc atttct                                                      16

<210>  9730
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9730
ggaagatggc atttc                                                       15

<210>  9731
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9731
ggaagatggc attt                                                        14

<210>  9732
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9732
ggaagatggc att                                                         13

<210>  9733
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9733
ggaagatggc at                                                          12

<210>  9734
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9734
ggaagatggc a                                                           11

<210>  9735
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  9735
ggaagatggc                                                             10

<210>  9736
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9736
gaagatggca tttctag                                                     17

<210>  9737
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9737
gaagatggca tttcta                                                      16

<210>  9738
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  9738
gaagatggca tttc                                                        14

<210>  9739
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9739
gaagatggca ttt                                                         13

<210>  9740
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9740
gaagatggca tt                                                          12

<210>  9741
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9741
gaagatggca t                                                           11

<210>  9742
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9742
gaagatggca                                                             10

<210>  9743
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9743
gaagatggc                                                              9

<210>  9744
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9744
aagatggcat ttctag                                                      16

<210>  9745
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9745
aagatggcat ttcta                                                       15

<210>  9746
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9746
aagatggcat ttct                                                        14

<210>  9747
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  9747
aagatggcat ttc                                                         13

<210>  9748
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9748
aagatggcat tt                                                          12

<210>  9749
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9749
aagatggcat t                                                           11

<210>  9750
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9750
aagatggcat                                                             10

<210>  9751
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9751
aagatggca                                                              9

<210>  9752
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9752
aagatggc                                                               8

<210>  9753
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9753
agatggcatt tctag                                                       15

<210>  9754
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9754
agatggcatt tcta                                                        14

<210>  9755
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9755
agatggcatt tct                                                         13

<210>  9756
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  9756
agatggcatt tc                                                          12

<210>  9757
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9757
agatggcatt t                                                           11

<210>  9758
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9758
agatggcatt                                                             10

<210>  9759
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9759
agatggcat                                                              9

<210>  9760
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  9760
agatggca                                                               8

<210>  9761
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9761
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  9762
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9762
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  9763
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9763
ctccaacatc aaggaagatg gcatttct                                         28

<210>  9764
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9764
ctccaacatc aaggaagatg gcatttc                                          27

<210>  9765
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9765
ctccaacatc aaggaagatg gcattt                                           26

<210>  9766
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9766
ctccaacatc aaggaagatg gcatt                                            25

<210>  9767
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9767
ctccaacatc aaggaagatg gcat                                             24

<210>  9768
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9768
ctccaacatc aaggaagatg gca                                              23

<210>  9769
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9769
ctccaacatc aaggaagatg gc                                               22

<210>  9770
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9770
ctccaacatc aaggaagatg g                                                21

<210>  9771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9771
ctccaacatc aaggaagatg                                                  20

<210>  9772
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9772
ctccaacatc aaggaagat                                                   19

<210>  9773
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9773
ctccaacatc aaggaaga                                                    18

<210>  9774
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9774
ctccaacatc aaggaag                                                     17

<210>  9775
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9775
tccaacatca aggaagatgg catttctag                                        29

<210>  9776
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9776
tccaacatca aggaagatgg catttcta                                         28

<210>  9777
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9777
tccaacatca aggaagatgg catttct                                          27

<210>  9778
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  9778
tccaacatca aggaagatgg catttc                                           26

<210>  9779
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9779
tccaacatca aggaagatgg cattt                                            25

<210>  9780
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9780
tccaacatca aggaagatgg catt                                             24

<210>  9781
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9781
tccaacatca aggaagatgg cat                                              23

<210>  9782
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9782
tccaacatca aggaagatgg ca                                               22

<210>  9783
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  9783
tccaacatca aggaagatgg c                                                21

<210>  9784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9784
tccaacatca aggaagatgg                                                  20

<210>  9785
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9785
tccaacatca aggaagatg                                                   19

<210>  9786
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9786
tccaacatca aggaagat                                                    18

<210>  9787
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9787
tccaacatca aggaaga                                                     17

<210>  9788
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9788
tccaacatca aggaag                                                      16

<210>  9789
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9789
ccaacatcaa ggaagatggc atttctag                                         28

<210>  9790
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9790
ccaacatcaa ggaagatggc atttcta                                          27

<210>  9791
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9791
ccaacatcaa ggaagatggc atttct                                           26

<210>  9792
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9792
ccaacatcaa ggaagatggc atttc                                            25

<210>  9793
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9793
ccaacatcaa ggaagatggc attt                                             24

<210>  9794
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9794
ccaacatcaa ggaagatggc att                                              23

<210>  9795
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9795
ccaacatcaa ggaagatggc at                                               22

<210>  9796
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9796
ccaacatcaa ggaagatggc a                                                21

<210>  9797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9797
ccaacatcaa ggaagatggc                                                  20

<210>  9798
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9798
ccaacatcaa ggaagatgg                                                   19

<210>  9799
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9799
ccaacatcaa ggaagatg                                                    18

<210>  9800
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9800
ccaacatcaa ggaagat                                                     17

<210>  9801
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9801
ccaacatcaa ggaaga                                                      16

<210>  9802
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9802
ccaacatcaa ggaag                                                       15

<210>  9803
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9803
caacatcaag gaagatggca tttctag                                          27

<210>  9804
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9804
caacatcaag gaagatggca tttcta                                           26

<210>  9805
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9805
caacatcaag gaagatggca tttct                                            25

<210>  9806
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9806
caacatcaag gaagatggca tttc                                             24

<210>  9807
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9807
caacatcaag gaagatggca ttt                                              23

<210>  9808
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9808
caacatcaag gaagatggca tt                                               22

<210>  9809
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9809
caacatcaag gaagatggca t                                                21

<210>  9810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9810
caacatcaag gaagatggca                                                  20

<210>  9811
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9811
caacatcaag gaagatggc                                                   19

<210>  9812
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9812
caacatcaag gaagatgg                                                    18

<210>  9813
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9813
caacatcaag gaagatg                                                     17

<210>  9814
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9814
caacatcaag gaagat                                                      16

<210>  9815
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9815
caacatcaag gaaga                                                       15

<210>  9816
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9816
caacatcaag gaag                                                        14

<210>  9817
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9817
aacatcaagg aagatggcat ttctag                                           26

<210>  9818
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9818
aacatcaagg aagatggcat ttcta                                            25

<210>  9819
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9819
aacatcaagg aagatggcat ttct                                             24

<210>  9820
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  9820
aacatcaagg aagatggcat ttc                                              23

<210>  9821
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9821
aacatcaagg aagatggcat tt                                               22

<210>  9822
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9822
aacatcaagg aagatggcat t                                                21

<210>  9823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9823
aacatcaagg aagatggcat                                                  20

<210>  9824
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9824
aacatcaagg aagatggca                                                   19

<210>  9825
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  9825
aacatcaagg aagatggc                                                    18

<210>  9826
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9826
aacatcaagg aagatgg                                                     17

<210>  9827
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9827
aacatcaagg aagatg                                                      16

<210>  9828
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9828
aacatcaagg aagat                                                       15

<210>  9829
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9829
aacatcaagg aaga                                                        14

<210>  9830
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  9830
aacatcaagg aag                                                         13

<210>  9831
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9831
acatcaagga agatggcatt tctag                                            25

<210>  9832
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9832
acatcaagga agatggcatt tcta                                             24

<210>  9833
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9833
acatcaagga agatggcatt tct                                              23

<210>  9834
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  9834
acatcaagga agatggcatt tc                                               22

<210>  9835
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9835
acatcaagga agatggcatt t                                                21

<210>  9836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9836
acatcaagga agatggcatt                                                  20

<210>  9837
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9837
acatcaagga agatggcat                                                   19

<210>  9838
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9838
acatcaagga agatggca                                                    18

<210>  9839
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  9839
acatcaagga agatggc                                                     17

<210>  9840
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9840
acatcaagga agatgg                                                      16

<210>  9841
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9841
acatcaagga agatg                                                       15

<210>  9842
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9842
acatcaagga agat                                                        14

<210>  9843
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9843
acatcaagga aga                                                         13

<210>  9844
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  9844
acatcaagga ag                                                          12

<210>  9845
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9845
catcaaggaa gatggcattt ctag                                             24

<210>  9846
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9846
catcaaggaa gatggcattt cta                                              23

<210>  9847
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9847
catcaaggaa gatggcattt ct                                               22

<210>  9848
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9848
catcaaggaa gatggcattt c                                                21

<210>  9849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9849
catcaaggaa gatggcattt                                                  20

<210>  9850
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9850
catcaaggaa gatggcatt                                                   19

<210>  9851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9851
catcaaggaa gatggcat                                                    18

<210>  9852
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9852
catcaaggaa gatggca                                                     17

<210>  9853
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9853
catcaaggaa gatggc                                                      16

<210>  9854
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9854
catcaaggaa gatgg                                                       15

<210>  9855
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9855
catcaaggaa gatg                                                        14

<210>  9856
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9856
catcaaggaa gat                                                         13

<210>  9857
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9857
catcaaggaa ga                                                          12

<210>  9858
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  9858
catcaaggaa g                                                           11

<210>  9859
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9859
atcaaggaag atggcatttc tag                                              23

<210>  9860
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9860
atcaaggaag atggcatttc ta                                               22

<210>  9861
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9861
atcaaggaag atggcatttc t                                                21

<210>  9862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  9862
atcaaggaag atggcatttc                                                  20

<210>  9863
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9863
atcaaggaag atggcattt                                                   19

<210>  9864
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9864
atcaaggaag atggcatt                                                    18

<210>  9865
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9865
atcaaggaag atggcat                                                     17

<210>  9866
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9866
atcaaggaag atggca                                                      16

<210>  9867
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  9867
atcaaggaag atggc                                                       15

<210>  9868
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9868
atcaaggaag atgg                                                        14

<210>  9869
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9869
atcaaggaag atg                                                         13

<210>  9870
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9870
atcaaggaag at                                                          12

<210>  9871
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9871
atcaaggaag a                                                           11

<210>  9872
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  9872
atcaaggaag                                                             10

<210>  9873
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9873
ggtaagttct gtccaagc                                                    18

<210>  9874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9874
gtaagttctg tccaagcc                                                    18

<210>  9875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9875
agtcggtaag ttctgtcc                                                    18

<210>  9876
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9876
ctgtccaagc ccggttga                                                    18

<210>  9877
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9877
taagttctgt ccaag                                                       15

<210>  9878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9878
ttctgtccaa gcccggttga                                                  20

<210>  9879
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9879
ttctgtccaa gcccggttg                                                   19

<210>  9880
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9880
ttctgtccaa gcccggtt                                                    18

<210>  9881
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9881
ttctgtccaa gcccggt                                                     17

<210>  9882
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9882
ttctgtccaa gcccgg                                                      16

<210>  9883
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9883
ttctgtccaa gcccg                                                       15

<210>  9884
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9884
ttctgtccaa gccc                                                        14

<210>  9885
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9885
ttctgtccaa gcc                                                         13

<210>  9886
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9886
ttctgtccaa gc                                                          12

<210>  9887
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9887
ttctgtccaa g                                                           11

<210>  9888
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9888
ttctgtccaa                                                             10

<210>  9889
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9889
ttctgtcca                                                              9

<210>  9890
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9890
ttctgtcc                                                               8

<210>  9891
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9891
tctgtccaag cccggttga                                                   19

<210>  9892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9892
tctgtccaag cccggttg                                                    18

<210>  9893
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9893
tctgtccaag cccggtt                                                     17

<210>  9894
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9894
tctgtccaag cccggt                                                      16

<210>  9895
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9895
tctgtccaag cccgg                                                       15

<210>  9896
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9896
tctgtccaag cccg                                                        14

<210>  9897
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9897
tctgtccaag ccc                                                         13

<210>  9898
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9898
tctgtccaag cc                                                          12

<210>  9899
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9899
tctgtccaag c                                                           11

<210>  9900
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9900
tctgtccaag                                                             10

<210>  9901
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9901
tctgtccaa                                                              9

<210>  9902
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9902
tctgtcca                                                               8

<210>  9903
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9903
ctgtccaagc ccggttg                                                     17

<210>  9904
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9904
ctgtccaagc ccggtt                                                      16

<210>  9905
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9905
ctgtccaagc ccggt                                                       15

<210>  9906
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9906
ctgtccaagc ccgg                                                        14

<210>  9907
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9907
ctgtccaagc ccg                                                         13

<210>  9908
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9908
ctgtccaagc cc                                                          12

<210>  9909
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9909
ctgtccaagc c                                                           11

<210>  9910
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9910
ctgtccaagc                                                             10

<210>  9911
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9911
ctgtccaag                                                              9

<210>  9912
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9912
ctgtccaa                                                               8

<210>  9913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9913
gttctgtcca agcccggttg                                                  20

<210>  9914
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9914
gttctgtcca agcccggtt                                                   19

<210>  9915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9915
gttctgtcca agcccggt                                                    18

<210>  9916
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9916
gttctgtcca agcccgg                                                     17

<210>  9917
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9917
gttctgtcca agcccg                                                      16

<210>  9918
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9918
gttctgtcca agccc                                                       15

<210>  9919
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9919
gttctgtcca agcc                                                        14

<210>  9920
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9920
gttctgtcca agc                                                         13

<210>  9921
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9921
gttctgtcca ag                                                          12

<210>  9922
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9922
gttctgtcca a                                                           11

<210>  9923
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9923
gttctgtcca                                                             10

<210>  9924
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9924
gttctgtcc                                                              9

<210>  9925
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9925
gttctgtc                                                               8

<210>  9926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9926
agttctgtcc aagcccggtt                                                  20

<210>  9927
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9927
agttctgtcc aagcccggt                                                   19

<210>  9928
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9928
agttctgtcc aagcccgg                                                    18

<210>  9929
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9929
agttctgtcc aagcccg                                                     17

<210>  9930
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9930
agttctgtcc aagccc                                                      16

<210>  9931
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9931
agttctgtcc aagcc                                                       15

<210>  9932
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9932
agttctgtcc aagc                                                        14

<210>  9933
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9933
agttctgtcc aag                                                         13

<210>  9934
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9934
agttctgtcc aa                                                          12

<210>  9935
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9935
agttctgtcc a                                                           11

<210>  9936
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9936
agttctgtcc                                                             10

<210>  9937
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9937
agttctgtc                                                              9

<210>  9938
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9938
agttctgt                                                               8

<210>  9939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9939
aagttctgtc caagcccggt                                                  20

<210>  9940
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9940
aagttctgtc caagcccgg                                                   19

<210>  9941
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9941
aagttctgtc caagcccg                                                    18

<210>  9942
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9942
aagttctgtc caagccc                                                     17

<210>  9943
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9943
aagttctgtc caagcc                                                      16

<210>  9944
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9944
aagttctgtc caagc                                                       15

<210>  9945
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9945
aagttctgtc caag                                                        14

<210>  9946
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9946
aagttctgtc caa                                                         13

<210>  9947
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9947
aagttctgtc ca                                                          12

<210>  9948
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9948
aagttctgtc c                                                           11

<210>  9949
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9949
aagttctgtc                                                             10

<210>  9950
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9950
aagttctgt                                                              9

<210>  9951
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9951
aagttctg                                                               8

<210>  9952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9952
taagttctgt ccaagcccgg                                                  20

<210>  9953
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9953
taagttctgt ccaagcccg                                                   19

<210>  9954
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9954
taagttctgt ccaagccc                                                    18

<210>  9955
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9955
taagttctgt ccaagcc                                                     17

<210>  9956
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9956
taagttctgt ccaagc                                                      16

<210>  9957
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9957
taagttctgt ccaa                                                        14

<210>  9958
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9958
taagttctgt cca                                                         13

<210>  9959
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9959
taagttctgt cc                                                          12

<210>  9960
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9960
taagttctgt c                                                           11

<210>  9961
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9961
taagttctgt                                                             10

<210>  9962
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9962
taagttctg                                                              9

<210>  9963
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9963
taagttct                                                               8

<210>  9964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9964
gtaagttctg tccaagcccg                                                  20

<210>  9965
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9965
gtaagttctg tccaagccc                                                   19

<210>  9966
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9966
gtaagttctg tccaagc                                                     17

<210>  9967
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9967
gtaagttctg tccaag                                                      16

<210>  9968
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9968
gtaagttctg tccaa                                                       15

<210>  9969
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9969
gtaagttctg tcca                                                        14

<210>  9970
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9970
gtaagttctg tcc                                                         13

<210>  9971
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9971
gtaagttctg tc                                                          12

<210>  9972
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9972
gtaagttctg t                                                           11

<210>  9973
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9973
gtaagttctg                                                             10

<210>  9974
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9974
gtaagttct                                                              9

<210>  9975
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  9975
gtaagttc                                                               8

<210>  9976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9976
ggtaagttct gtccaagccc                                                  20

<210>  9977
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9977
ggtaagttct gtccaagcc                                                   19

<210>  9978
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9978
ggtaagttct gtccaag                                                     17

<210>  9979
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9979
ggtaagttct gtccaa                                                      16

<210>  9980
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9980
ggtaagttct gtcca                                                       15

<210>  9981
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9981
ggtaagttct gtcc                                                        14

<210>  9982
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9982
ggtaagttct gtc                                                         13

<210>  9983
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9983
ggtaagttct gt                                                          12

<210>  9984
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9984
ggtaagttct g                                                           11

<210>  9985
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9985
ggtaagttct                                                             10

<210>  9986
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  9986
ggtaagttc                                                              9

<210>  9987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  9987
cggtaagttc tgtccaagcc                                                  20

<210>  9988
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  9988
cggtaagttc tgtccaagc                                                   19

<210>  9989
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  9989
cggtaagttc tgtccaag                                                    18

<210>  9990
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  9990
cggtaagttc tgtccaa                                                     17

<210>  9991
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  9991
cggtaagttc tgtcca                                                      16

<210>  9992
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  9992
cggtaagttc tgtcc                                                       15

<210>  9993
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  9993
cggtaagttc tgtc                                                        14

<210>  9994
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  9994
cggtaagttc tgt                                                         13

<210>  9995
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  9995
cggtaagttc tg                                                          12

<210>  9996
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  9996
cggtaagttc t                                                           11

<210>  9997
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  9997
cggtaagttc                                                             10

<210>  9998
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  9998
cggtaagtt                                                              9

<210>  9999
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  9999
cggtaagt                                                               8

<210>  10000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10000
tcggtaagtt ctgtccaagc                                                  20

<210>  10001
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10001
tcggtaagtt ctgtccaag                                                   19

<210>  10002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10002
tcggtaagtt ctgtccaa                                                    18

<210>  10003
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10003
tcggtaagtt ctgtcca                                                     17

<210>  10004
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10004
tcggtaagtt ctgtcc                                                      16

<210>  10005
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10005
tcggtaagtt ctgtc                                                       15

<210>  10006
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10006
tcggtaagtt ctgt                                                        14

<210>  10007
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10007
tcggtaagtt ctg                                                         13

<210>  10008
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10008
tcggtaagtt ct                                                          12

<210>  10009
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10009
tcggtaagtt c                                                           11

<210>  10010
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10010
tcggtaagtt                                                             10

<210>  10011
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10011
tcggtaagt                                                              9

<210>  10012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10012
gtcggtaagt tctgtccaag                                                  20

<210>  10013
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10013
gtcggtaagt tctgtccaa                                                   19

<210>  10014
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10014
gtcggtaagt tctgtcca                                                    18

<210>  10015
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10015
gtcggtaagt tctgtcc                                                     17

<210>  10016
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10016
gtcggtaagt tctgtc                                                      16

<210>  10017
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10017
gtcggtaagt tctgt                                                       15

<210>  10018
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10018
gtcggtaagt tctg                                                        14

<210>  10019
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10019
gtcggtaagt tct                                                         13

<210>  10020
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10020
gtcggtaagt tc                                                          12

<210>  10021
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10021
gtcggtaagt t                                                           11

<210>  10022
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10022
gtcggtaagt                                                             10

<210>  10023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10023
agtcggtaag ttctgtccaa                                                  20

<210>  10024
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10024
agtcggtaag ttctgtcca                                                   19

<210>  10025
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10025
agtcggtaag ttctgtc                                                     17

<210>  10026
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10026
agtcggtaag ttctgt                                                      16

<210>  10027
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10027
agtcggtaag ttctg                                                       15

<210>  10028
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10028
agtcggtaag ttct                                                        14

<210>  10029
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10029
agtcggtaag ttc                                                         13

<210>  10030
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10030
agtcggtaag tt                                                          12

<210>  10031
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10031
agtcggtaag t                                                           11

<210>  10032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10032
cagtcggtaa gttctgtcca                                                  20

<210>  10033
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10033
cagtcggtaa gttctgtcc                                                   19

<210>  10034
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10034
cagtcggtaa gttctgtc                                                    18

<210>  10035
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10035
cagtcggtaa gttctgt                                                     17

<210>  10036
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10036
cagtcggtaa gttctg                                                      16

<210>  10037
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10037
cagtcggtaa gttct                                                       15

<210>  10038
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10038
cagtcggtaa gttc                                                        14

<210>  10039
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10039
cagtcggtaa gtt                                                         13

<210>  10040
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10040
cagtcggtaa gt                                                          12

<210>  10041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10041
ccagtcggta agttctgtcc                                                  20

<210>  10042
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10042
ccagtcggta agttctgtc                                                   19

<210>  10043
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10043
ccagtcggta agttctgt                                                    18

<210>  10044
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10044
ccagtcggta agttctg                                                     17

<210>  10045
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10045
ccagtcggta agttct                                                      16

<210>  10046
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10046
ccagtcggta agttc                                                       15

<210>  10047
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10047
ccagtcggta agtt                                                        14

<210>  10048
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10048
ccagtcggta agt                                                         13

<210>  10049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10049
gccagtcggt aagttctgtc                                                  20

<210>  10050
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10050
gccagtcggt aagttctgt                                                   19

<210>  10051
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10051
gccagtcggt aagttctg                                                    18

<210>  10052
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10052
gccagtcggt aagttct                                                     17

<210>  10053
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10053
gccagtcggt aagttc                                                      16

<210>  10054
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10054
gccagtcggt aagtt                                                       15

<210>  10055
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10055
gccagtcggt aagt                                                        14

<210>  10056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10056
tcaaggaaga tggcatttct                                                  20

<210>  10057
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10057
tcaaggaaga tggcatttct ag                                               22

<210>  10058
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10058
tcaaggaaga tggcat                                                      16

<210>  10059
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10059
gaagatggca tttct                                                       15

<210>  10060
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10060
tcaaggaaga tggcatttct a                                                21

<210>  10061
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10061
tcaaggaaga tggcatttc                                                   19

<210>  10062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10062
tcaaggaaga tggcattt                                                    18

<210>  10063
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10063
tcaaggaaga tggcatt                                                     17

<210>  10064
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10064
tcaaggaaga tggca                                                       15

<210>  10065
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10065
tcaaggaaga tggc                                                        14

<210>  10066
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10066
tcaaggaaga tgg                                                         13

<210>  10067
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10067
tcaaggaaga tg                                                          12

<210>  10068
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10068
tcaaggaaga t                                                           11

<210>  10069
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10069
tcaaggaaga                                                             10

<210>  10070
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10070
tcaaggaag                                                              9

<210>  10071
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10071
caaggaagat ggcatttcta g                                                21

<210>  10072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10072
caaggaagat ggcatttcta                                                  20

<210>  10073
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10073
caaggaagat ggcatttct                                                   19

<210>  10074
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10074
caaggaagat ggcatttc                                                    18

<210>  10075
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10075
caaggaagat ggcattt                                                     17

<210>  10076
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10076
caaggaagat ggcatt                                                      16

<210>  10077
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10077
caaggaagat ggcat                                                       15

<210>  10078
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10078
caaggaagat ggca                                                        14

<210>  10079
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10079
caaggaagat ggc                                                         13

<210>  10080
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10080
caaggaagat gg                                                          12

<210>  10081
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10081
caaggaagat g                                                           11

<210>  10082
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10082
caaggaagat                                                             10

<210>  10083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10083
aaggaagatg gcatttctag                                                  20

<210>  10084
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10084
aaggaagatg gcatttcta                                                   19

<210>  10085
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10085
aaggaagatg gcatttct                                                    18

<210>  10086
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10086
aaggaagatg gcatttc                                                     17

<210>  10087
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10087
aaggaagatg gcattt                                                      16

<210>  10088
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10088
aaggaagatg gcatt                                                       15

<210>  10089
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10089
aaggaagatg gcat                                                        14

<210>  10090
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10090
aaggaagatg gca                                                         13

<210>  10091
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10091
aaggaagatg gc                                                          12

<210>  10092
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10092
aggaagatgg catttctag                                                   19

<210>  10093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10093
aggaagatgg catttcta                                                    18

<210>  10094
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10094
aggaagatgg catttct                                                     17

<210>  10095
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10095
aggaagatgg catttc                                                      16

<210>  10096
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10096
aggaagatgg cattt                                                       15

<210>  10097
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10097
aggaagatgg catt                                                        14

<210>  10098
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10098
aggaagatgg cat                                                         13

<210>  10099
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10099
aggaagatgg ca                                                          12

<210>  10100
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10100
ggaagatggc atttctag                                                    18

<210>  10101
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10101
ggaagatggc atttcta                                                     17

<210>  10102
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10102
ggaagatggc atttct                                                      16

<210>  10103
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10103
ggaagatggc atttc                                                       15

<210>  10104
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10104
ggaagatggc attt                                                        14

<210>  10105
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10105
ggaagatggc att                                                         13

<210>  10106
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10106
ggaagatggc at                                                          12

<210>  10107
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10107
ggaagatggc a                                                           11

<210>  10108
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10108
ggaagatggc                                                             10

<210>  10109
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10109
gaagatggca tttctag                                                     17

<210>  10110
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10110
gaagatggca tttcta                                                      16

<210>  10111
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10111
gaagatggca tttc                                                        14

<210>  10112
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10112
gaagatggca ttt                                                         13

<210>  10113
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10113
gaagatggca tt                                                          12

<210>  10114
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10114
gaagatggca t                                                           11

<210>  10115
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10115
gaagatggca                                                             10

<210>  10116
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10116
gaagatggc                                                              9

<210>  10117
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10117
aagatggcat ttctag                                                      16

<210>  10118
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10118
aagatggcat ttcta                                                       15

<210>  10119
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10119
aagatggcat ttct                                                        14

<210>  10120
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10120
aagatggcat ttc                                                         13

<210>  10121
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10121
aagatggcat tt                                                          12

<210>  10122
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10122
aagatggcat t                                                           11

<210>  10123
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10123
aagatggcat                                                             10

<210>  10124
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10124
aagatggca                                                              9

<210>  10125
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10125
aagatggc                                                               8

<210>  10126
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10126
agatggcatt tctag                                                       15

<210>  10127
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10127
agatggcatt tcta                                                        14

<210>  10128
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10128
agatggcatt tct                                                         13

<210>  10129
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10129
agatggcatt tc                                                          12

<210>  10130
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10130
agatggcatt t                                                           11

<210>  10131
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10131
agatggcatt                                                             10

<210>  10132
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10132
agatggcat                                                              9

<210>  10133
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  10133
agatggca                                                               8

<210>  10134
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  10134
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  10135
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  10135
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  10136
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  10136
ctccaacatc aaggaagatg gcatttct                                         28

<210>  10137
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10137
ctccaacatc aaggaagatg gcatttc                                          27

<210>  10138
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10138
ctccaacatc aaggaagatg gcattt                                           26

<210>  10139
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10139
ctccaacatc aaggaagatg gcatt                                            25

<210>  10140
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10140
ctccaacatc aaggaagatg gcat                                             24

<210>  10141
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10141
ctccaacatc aaggaagatg gca                                              23

<210>  10142
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10142
ctccaacatc aaggaagatg gc                                               22

<210>  10143
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10143
ctccaacatc aaggaagatg g                                                21

<210>  10144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10144
ctccaacatc aaggaagatg                                                  20

<210>  10145
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10145
ctccaacatc aaggaagat                                                   19

<210>  10146
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10146
ctccaacatc aaggaaga                                                    18

<210>  10147
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10147
ctccaacatc aaggaag                                                     17

<210>  10148
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  10148
tccaacatca aggaagatgg catttctag                                        29

<210>  10149
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  10149
tccaacatca aggaagatgg catttcta                                         28

<210>  10150
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10150
tccaacatca aggaagatgg catttct                                          27

<210>  10151
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10151
tccaacatca aggaagatgg catttc                                           26

<210>  10152
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10152
tccaacatca aggaagatgg cattt                                            25

<210>  10153
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10153
tccaacatca aggaagatgg catt                                             24

<210>  10154
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10154
tccaacatca aggaagatgg cat                                              23

<210>  10155
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10155
tccaacatca aggaagatgg ca                                               22

<210>  10156
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10156
tccaacatca aggaagatgg c                                                21

<210>  10157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10157
tccaacatca aggaagatgg                                                  20

<210>  10158
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10158
tccaacatca aggaagatg                                                   19

<210>  10159
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10159
tccaacatca aggaagat                                                    18

<210>  10160
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10160
tccaacatca aggaaga                                                     17

<210>  10161
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10161
tccaacatca aggaag                                                      16

<210>  10162
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  10162
ccaacatcaa ggaagatggc atttctag                                         28

<210>  10163
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10163
ccaacatcaa ggaagatggc atttcta                                          27

<210>  10164
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10164
ccaacatcaa ggaagatggc atttct                                           26

<210>  10165
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10165
ccaacatcaa ggaagatggc atttc                                            25

<210>  10166
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10166
ccaacatcaa ggaagatggc attt                                             24

<210>  10167
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10167
ccaacatcaa ggaagatggc att                                              23

<210>  10168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10168
ccaacatcaa ggaagatggc at                                               22

<210>  10169
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10169
ccaacatcaa ggaagatggc a                                                21

<210>  10170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10170
ccaacatcaa ggaagatggc                                                  20

<210>  10171
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10171
ccaacatcaa ggaagatgg                                                   19

<210>  10172
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10172
ccaacatcaa ggaagatg                                                    18

<210>  10173
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10173
ccaacatcaa ggaagat                                                     17

<210>  10174
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10174
ccaacatcaa ggaaga                                                      16

<210>  10175
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10175
ccaacatcaa ggaag                                                       15

<210>  10176
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10176
caacatcaag gaagatggca tttctag                                          27

<210>  10177
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10177
caacatcaag gaagatggca tttcta                                           26

<210>  10178
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10178
caacatcaag gaagatggca tttct                                            25

<210>  10179
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10179
caacatcaag gaagatggca tttc                                             24

<210>  10180
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10180
caacatcaag gaagatggca ttt                                              23

<210>  10181
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10181
caacatcaag gaagatggca tt                                               22

<210>  10182
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10182
caacatcaag gaagatggca t                                                21

<210>  10183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10183
caacatcaag gaagatggca                                                  20

<210>  10184
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10184
caacatcaag gaagatggc                                                   19

<210>  10185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10185
caacatcaag gaagatgg                                                    18

<210>  10186
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10186
caacatcaag gaagatg                                                     17

<210>  10187
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10187
caacatcaag gaagat                                                      16

<210>  10188
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10188
caacatcaag gaaga                                                       15

<210>  10189
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10189
caacatcaag gaag                                                        14

<210>  10190
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10190
aacatcaagg aagatggcat ttctag                                           26

<210>  10191
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10191
aacatcaagg aagatggcat ttcta                                            25

<210>  10192
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10192
aacatcaagg aagatggcat ttct                                             24

<210>  10193
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10193
aacatcaagg aagatggcat ttc                                              23

<210>  10194
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10194
aacatcaagg aagatggcat tt                                               22

<210>  10195
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10195
aacatcaagg aagatggcat t                                                21

<210>  10196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10196
aacatcaagg aagatggcat                                                  20

<210>  10197
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10197
aacatcaagg aagatggca                                                   19

<210>  10198
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10198
aacatcaagg aagatggc                                                    18

<210>  10199
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10199
aacatcaagg aagatgg                                                     17

<210>  10200
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10200
aacatcaagg aagatg                                                      16

<210>  10201
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10201
aacatcaagg aagat                                                       15

<210>  10202
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10202
aacatcaagg aaga                                                        14

<210>  10203
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10203
aacatcaagg aag                                                         13

<210>  10204
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10204
acatcaagga agatggcatt tctag                                            25

<210>  10205
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10205
acatcaagga agatggcatt tcta                                             24

<210>  10206
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10206
acatcaagga agatggcatt tct                                              23

<210>  10207
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10207
acatcaagga agatggcatt tc                                               22

<210>  10208
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10208
acatcaagga agatggcatt t                                                21

<210>  10209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10209
acatcaagga agatggcatt                                                  20

<210>  10210
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10210
acatcaagga agatggcat                                                   19

<210>  10211
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10211
acatcaagga agatggca                                                    18

<210>  10212
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10212
acatcaagga agatggc                                                     17

<210>  10213
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10213
acatcaagga agatgg                                                      16

<210>  10214
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10214
acatcaagga agatg                                                       15

<210>  10215
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10215
acatcaagga agat                                                        14

<210>  10216
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10216
acatcaagga aga                                                         13

<210>  10217
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10217
acatcaagga ag                                                          12

<210>  10218
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10218
catcaaggaa gatggcattt ctag                                             24

<210>  10219
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10219
catcaaggaa gatggcattt cta                                              23

<210>  10220
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10220
catcaaggaa gatggcattt ct                                               22

<210>  10221
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10221
catcaaggaa gatggcattt c                                                21

<210>  10222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10222
catcaaggaa gatggcattt                                                  20

<210>  10223
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10223
catcaaggaa gatggcatt                                                   19

<210>  10224
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10224
catcaaggaa gatggcat                                                    18

<210>  10225
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10225
catcaaggaa gatggca                                                     17

<210>  10226
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10226
catcaaggaa gatggc                                                      16

<210>  10227
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10227
catcaaggaa gatgg                                                       15

<210>  10228
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10228
catcaaggaa gatg                                                        14

<210>  10229
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10229
catcaaggaa gat                                                         13

<210>  10230
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10230
catcaaggaa ga                                                          12

<210>  10231
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10231
catcaaggaa g                                                           11

<210>  10232
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10232
atcaaggaag atggcatttc tag                                              23

<210>  10233
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10233
atcaaggaag atggcatttc ta                                               22

<210>  10234
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10234
atcaaggaag atggcatttc t                                                21

<210>  10235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10235
atcaaggaag atggcatttc                                                  20

<210>  10236
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10236
atcaaggaag atggcattt                                                   19

<210>  10237
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10237
atcaaggaag atggcatt                                                    18

<210>  10238
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10238
atcaaggaag atggcat                                                     17

<210>  10239
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10239
atcaaggaag atggca                                                      16

<210>  10240
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10240
atcaaggaag atggc                                                       15

<210>  10241
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10241
atcaaggaag atgg                                                        14

<210>  10242
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10242
atcaaggaag atg                                                         13

<210>  10243
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10243
atcaaggaag at                                                          12

<210>  10244
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10244
atcaaggaag a                                                           11

<210>  10245
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10245
atcaaggaag                                                             10

<210>  10246
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10246
ggtaagttct gtccaagc                                                    18

<210>  10247
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10247
gtaagttctg tccaagcc                                                    18

<210>  10248
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10248
agtcggtaag ttctgtcc                                                    18

<210>  10249
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10249
ctgtccaagc ccggttga                                                    18

<210>  10250
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  10250
taagttctgt ccaag                                                       15

<210>  10251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10251
ttctgtccaa gcccggttga                                                  20

<210>  10252
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10252
ttctgtccaa gcccggttg                                                   19

<210>  10253
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10253
ttctgtccaa gcccggtt                                                    18

<210>  10254
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10254
ttctgtccaa gcccggt                                                     17

<210>  10255
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10255
ttctgtccaa gcccgg                                                      16

<210>  10256
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10256
ttctgtccaa gcccg                                                       15

<210>  10257
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  5-methyl

<400>  10257
ttctgtccaa gccc                                                        14

<210>  10258
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  10258
ttctgtccaa gcc                                                         13

<210>  10259
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10259
ttctgtccaa gc                                                          12

<210>  10260
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  10260
ttctgtccaa g                                                           11

<210>  10261
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  10261
ttctgtccaa                                                             10

<210>  10262
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  10262
ttctgtcca                                                              9

<210>  10263
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  5-methyl

<400>  10263
ttctgtcc                                                               8

<210>  10264
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10264
tctgtccaag cccggttga                                                   19

<210>  10265
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10265
tctgtccaag cccggttg                                                    18

<210>  10266
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10266
tctgtccaag cccggtt                                                     17

<210>  10267
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10267
tctgtccaag cccggt                                                      16

<210>  10268
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10268
tctgtccaag cccgg                                                       15

<210>  10269
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10269
tctgtccaag cccg                                                        14

<210>  10270
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  5-methyl

<400>  10270
tctgtccaag ccc                                                         13

<210>  10271
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  10271
tctgtccaag cc                                                          12

<210>  10272
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10272
tctgtccaag c                                                           11

<210>  10273
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  10273
tctgtccaag                                                             10

<210>  10274
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  10274
tctgtccaa                                                              9

<210>  10275
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  5-methyl

<400>  10275
tctgtcca                                                               8

<210>  10276
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10276
ctgtccaagc ccggttg                                                     17

<210>  10277
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10277
ctgtccaagc ccggtt                                                      16

<210>  10278
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10278
ctgtccaagc ccggt                                                       15

<210>  10279
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10279
ctgtccaagc ccgg                                                        14

<210>  10280
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10280
ctgtccaagc ccg                                                         13

<210>  10281
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10281
ctgtccaagc cc                                                          12

<210>  10282
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10282
ctgtccaagc c                                                           11

<210>  10283
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10283
ctgtccaagc                                                             10

<210>  10284
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10284
ctgtccaag                                                              9

<210>  10285
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  10285
ctgtccaa                                                               8

<210>  10286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  10286
gttctgtcca agcccggttg                                                  20

<210>  10287
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  10287
gttctgtcca agcccggtt                                                   19

<210>  10288
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  10288
gttctgtcca agcccggt                                                    18

<210>  10289
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  10289
gttctgtcca agcccgg                                                     17

<210>  10290
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  10290
gttctgtcca agcccg                                                      16

<210>  10291
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  5-methyl

<400>  10291
gttctgtcca agccc                                                       15

<210>  10292
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  10292
gttctgtcca agcc                                                        14

<210>  10293
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10293
gttctgtcca agc                                                         13

<210>  10294
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  10294
gttctgtcca ag                                                          12

<210>  10295
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  10295
gttctgtcca a                                                           11

<210>  10296
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  10296
gttctgtcca                                                             10

<210>  10297
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  5-methyl

<400>  10297
gttctgtcc                                                              9

<210>  10298
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10298
gttctgtc                                                               8

<210>  10299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  10299
agttctgtcc aagcccggtt                                                  20

<210>  10300
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  10300
agttctgtcc aagcccggt                                                   19

<210>  10301
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  10301
agttctgtcc aagcccgg                                                    18

<210>  10302
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  10302
agttctgtcc aagcccg                                                     17

<210>  10303
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  5-methyl

<400>  10303
agttctgtcc aagccc                                                      16

<210>  10304
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<400>  10304
agttctgtcc aagcc                                                       15

<210>  10305
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10305
agttctgtcc aagc                                                        14

<210>  10306
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  10306
agttctgtcc aag                                                         13

<210>  10307
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  10307
agttctgtcc aa                                                          12

<210>  10308
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  10308
agttctgtcc a                                                           11

<210>  10309
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  5-methyl

<400>  10309
agttctgtcc                                                             10

<210>  10310
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10310
agttctgtc                                                              9

<210>  10311
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  10311
agttctgt                                                               8

<210>  10312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  10312
aagttctgtc caagcccggt                                                  20

<210>  10313
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  10313
aagttctgtc caagcccgg                                                   19

<210>  10314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  10314
aagttctgtc caagcccg                                                    18

<210>  10315
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  5-methyl

<400>  10315
aagttctgtc caagccc                                                     17

<210>  10316
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  10316
aagttctgtc caagcc                                                      16

<210>  10317
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10317
aagttctgtc caagc                                                       15

<210>  10318
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  10318
aagttctgtc caag                                                        14

<210>  10319
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  10319
aagttctgtc caa                                                         13

<210>  10320
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  10320
aagttctgtc ca                                                          12

<210>  10321
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5-methyl

<400>  10321
aagttctgtc c                                                           11

<210>  10322
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10322
aagttctgtc                                                             10

<210>  10323
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10323
aagttctgt                                                              9

<210>  10324
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10324
aagttctg                                                               8

<210>  10325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  10325
taagttctgt ccaagcccgg                                                  20

<210>  10326
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  10326
taagttctgt ccaagcccg                                                   19

<210>  10327
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  5-methyl

<400>  10327
taagttctgt ccaagccc                                                    18

<210>  10328
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  10328
taagttctgt ccaagcc                                                     17

<210>  10329
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10329
taagttctgt ccaagc                                                      16

<210>  10330
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  10330
taagttctgt ccaa                                                        14

<210>  10331
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  10331
taagttctgt cca                                                         13

<210>  10332
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  10332
taagttctgt cc                                                          12

<210>  10333
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10333
taagttctgt c                                                           11

<210>  10334
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10334
taagttctgt                                                             10

<210>  10335
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10335
taagttctg                                                              9

<210>  10336
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10336
taagttct                                                               8

<210>  10337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  10337
gtaagttctg tccaagcccg                                                  20

<210>  10338
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  5-methyl

<400>  10338
gtaagttctg tccaagccc                                                   19

<210>  10339
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10339
gtaagttctg tccaagc                                                     17

<210>  10340
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  10340
gtaagttctg tccaag                                                      16

<210>  10341
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  10341
gtaagttctg tccaa                                                       15

<210>  10342
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  10342
gtaagttctg tcca                                                        14

<210>  10343
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<400>  10343
gtaagttctg tcc                                                         13

<210>  10344
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10344
gtaagttctg tc                                                          12

<210>  10345
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10345
gtaagttctg t                                                           11

<210>  10346
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10346
gtaagttctg                                                             10

<210>  10347
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10347
gtaagttct                                                              9

<210>  10348
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10348
gtaagttc                                                               8

<210>  10349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  5-methyl

<400>  10349
ggtaagttct gtccaagccc                                                  20

<210>  10350
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<400>  10350
ggtaagttct gtccaagcc                                                   19

<210>  10351
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  10351
ggtaagttct gtccaag                                                     17

<210>  10352
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  10352
ggtaagttct gtccaa                                                      16

<210>  10353
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  10353
ggtaagttct gtcca                                                       15

<210>  10354
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<400>  10354
ggtaagttct gtcc                                                        14

<210>  10355
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10355
ggtaagttct gtc                                                         13

<210>  10356
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10356
ggtaagttct gt                                                          12

<210>  10357
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10357
ggtaagttct g                                                           11

<210>  10358
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10358
ggtaagttct                                                             10

<210>  10359
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10359
ggtaagttc                                                              9

<210>  10360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10360
cggtaagttc tgtccaagcc                                                  20

<210>  10361
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10361
cggtaagttc tgtccaagc                                                   19

<210>  10362
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10362
cggtaagttc tgtccaag                                                    18

<210>  10363
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10363
cggtaagttc tgtccaa                                                     17

<210>  10364
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10364
cggtaagttc tgtcca                                                      16

<210>  10365
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10365
cggtaagttc tgtcc                                                       15

<210>  10366
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10366
cggtaagttc tgtc                                                        14

<210>  10367
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10367
cggtaagttc tgt                                                         13

<210>  10368
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10368
cggtaagttc tg                                                          12

<210>  10369
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10369
cggtaagttc t                                                           11

<210>  10370
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10370
cggtaagttc                                                             10

<210>  10371
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10371
cggtaagtt                                                              9

<210>  10372
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  10372
cggtaagt                                                               8

<210>  10373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  10373
tcggtaagtt ctgtccaagc                                                  20

<210>  10374
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  10374
tcggtaagtt ctgtccaag                                                   19

<210>  10375
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  10375
tcggtaagtt ctgtccaa                                                    18

<210>  10376
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  10376
tcggtaagtt ctgtcca                                                     17

<210>  10377
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5-methyl

<400>  10377
tcggtaagtt ctgtcc                                                      16

<210>  10378
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10378
tcggtaagtt ctgtc                                                       15

<210>  10379
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10379
tcggtaagtt ctgt                                                        14

<210>  10380
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10380
tcggtaagtt ctg                                                         13

<210>  10381
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10381
tcggtaagtt ct                                                          12

<210>  10382
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10382
tcggtaagtt c                                                           11

<210>  10383
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10383
tcggtaagtt                                                             10

<210>  10384
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10384
tcggtaagt                                                              9

<210>  10385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  10385
gtcggtaagt tctgtccaag                                                  20

<210>  10386
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  10386
gtcggtaagt tctgtccaa                                                   19

<210>  10387
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  10387
gtcggtaagt tctgtcca                                                    18

<210>  10388
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5-methyl

<400>  10388
gtcggtaagt tctgtcc                                                     17

<210>  10389
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10389
gtcggtaagt tctgtc                                                      16

<210>  10390
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10390
gtcggtaagt tctgt                                                       15

<210>  10391
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10391
gtcggtaagt tctg                                                        14

<210>  10392
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10392
gtcggtaagt tct                                                         13

<210>  10393
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10393
gtcggtaagt tc                                                          12

<210>  10394
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10394
gtcggtaagt t                                                           11

<210>  10395
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10395
gtcggtaagt                                                             10

<210>  10396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10396
agtcggtaag ttctgtccaa                                                  20

<210>  10397
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10397
agtcggtaag ttctgtcca                                                   19

<210>  10398
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10398
agtcggtaag ttctgtc                                                     17

<210>  10399
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10399
agtcggtaag ttctgt                                                      16

<210>  10400
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10400
agtcggtaag ttctg                                                       15

<210>  10401
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10401
agtcggtaag ttct                                                        14

<210>  10402
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10402
agtcggtaag ttc                                                         13

<210>  10403
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  10403
agtcggtaag tt                                                          12

<210>  10404
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<400>  10404
agtcggtaag t                                                           11

<210>  10405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10405
cagtcggtaa gttctgtcca                                                  20

<210>  10406
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10406
cagtcggtaa gttctgtcc                                                   19

<210>  10407
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10407
cagtcggtaa gttctgtc                                                    18

<210>  10408
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10408
cagtcggtaa gttctgt                                                     17

<210>  10409
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10409
cagtcggtaa gttctg                                                      16

<210>  10410
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10410
cagtcggtaa gttct                                                       15

<210>  10411
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10411
cagtcggtaa gttc                                                        14

<210>  10412
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10412
cagtcggtaa gtt                                                         13

<210>  10413
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10413
cagtcggtaa gt                                                          12

<210>  10414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10414
ccagtcggta agttctgtcc                                                  20

<210>  10415
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10415
ccagtcggta agttctgtc                                                   19

<210>  10416
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10416
ccagtcggta agttctgt                                                    18

<210>  10417
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10417
ccagtcggta agttctg                                                     17

<210>  10418
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10418
ccagtcggta agttct                                                      16

<210>  10419
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10419
ccagtcggta agttc                                                       15

<210>  10420
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10420
ccagtcggta agtt                                                        14

<210>  10421
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10421
ccagtcggta agt                                                         13

<210>  10422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  10422
gccagtcggt aagttctgtc                                                  20

<210>  10423
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10423
gccagtcggt aagttctgt                                                   19

<210>  10424
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10424
gccagtcggt aagttctg                                                    18

<210>  10425
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10425
gccagtcggt aagttct                                                     17

<210>  10426
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10426
gccagtcggt aagttc                                                      16

<210>  10427
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10427
gccagtcggt aagtt                                                       15

<210>  10428
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10428
gccagtcggt aagt                                                        14

<210>  10429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  10429
tcaaggaaga tggcatttct                                                  20

<210>  10430
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  10430
tcaaggaaga tggcatttct ag                                               22

<210>  10431
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10431
tcaaggaaga tggcat                                                      16

<210>  10432
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10432
gaagatggca tttct                                                       15

<210>  10433
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  10433
tcaaggaaga tggcatttct a                                                21

<210>  10434
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  10434
tcaaggaaga tggcatttc                                                   19

<210>  10435
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10435
tcaaggaaga tggcattt                                                    18

<210>  10436
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10436
tcaaggaaga tggcatt                                                     17

<210>  10437
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10437
tcaaggaaga tggca                                                       15

<210>  10438
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10438
tcaaggaaga tggc                                                        14

<210>  10439
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10439
tcaaggaaga tgg                                                         13

<210>  10440
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10440
tcaaggaaga tg                                                          12

<210>  10441
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10441
tcaaggaaga t                                                           11

<210>  10442
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10442
tcaaggaaga                                                             10

<210>  10443
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<400>  10443
tcaaggaag                                                              9

<210>  10444
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10444
caaggaagat ggcatttcta g                                                21

<210>  10445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10445
caaggaagat ggcatttcta                                                  20

<210>  10446
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10446
caaggaagat ggcatttct                                                   19

<210>  10447
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10447
caaggaagat ggcatttc                                                    18

<210>  10448
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10448
caaggaagat ggcattt                                                     17

<210>  10449
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10449
caaggaagat ggcatt                                                      16

<210>  10450
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10450
caaggaagat ggcat                                                       15

<210>  10451
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10451
caaggaagat ggca                                                        14

<210>  10452
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10452
caaggaagat ggc                                                         13

<210>  10453
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10453
caaggaagat gg                                                          12

<210>  10454
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10454
caaggaagat g                                                           11

<210>  10455
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10455
caaggaagat                                                             10

<210>  10456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10456
aaggaagatg gcatttctag                                                  20

<210>  10457
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10457
aaggaagatg gcatttcta                                                   19

<210>  10458
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10458
aaggaagatg gcatttct                                                    18

<210>  10459
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10459
aaggaagatg gcatttc                                                     17

<210>  10460
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10460
aaggaagatg gcattt                                                      16

<210>  10461
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10461
aaggaagatg gcatt                                                       15

<210>  10462
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10462
aaggaagatg gcat                                                        14

<210>  10463
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10463
aaggaagatg gca                                                         13

<210>  10464
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10464
aaggaagatg gc                                                          12

<210>  10465
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10465
aggaagatgg catttctag                                                   19

<210>  10466
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10466
aggaagatgg catttcta                                                    18

<210>  10467
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10467
aggaagatgg catttct                                                     17

<210>  10468
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<400>  10468
aggaagatgg catttc                                                      16

<210>  10469
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10469
aggaagatgg cattt                                                       15

<210>  10470
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10470
aggaagatgg catt                                                        14

<210>  10471
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10471
aggaagatgg cat                                                         13

<210>  10472
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5-methyl

<400>  10472
aggaagatgg ca                                                          12

<210>  10473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10473
ggaagatggc atttctag                                                    18

<210>  10474
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10474
ggaagatggc atttcta                                                     17

<210>  10475
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10475
ggaagatggc atttct                                                      16

<210>  10476
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10476
ggaagatggc atttc                                                       15

<210>  10477
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10477
ggaagatggc attt                                                        14

<210>  10478
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10478
ggaagatggc att                                                         13

<210>  10479
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10479
ggaagatggc at                                                          12

<210>  10480
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10480
ggaagatggc a                                                           11

<210>  10481
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<400>  10481
ggaagatggc                                                             10

<210>  10482
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10482
gaagatggca tttctag                                                     17

<210>  10483
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10483
gaagatggca tttcta                                                      16

<210>  10484
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  10484
gaagatggca tttc                                                        14

<210>  10485
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10485
gaagatggca ttt                                                         13

<210>  10486
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10486
gaagatggca tt                                                          12

<210>  10487
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10487
gaagatggca t                                                           11

<210>  10488
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10488
gaagatggca                                                             10

<210>  10489
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10489
gaagatggc                                                              9

<210>  10490
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10490
aagatggcat ttctag                                                      16

<210>  10491
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10491
aagatggcat ttcta                                                       15

<210>  10492
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10492
aagatggcat ttct                                                        14

<210>  10493
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<400>  10493
aagatggcat ttc                                                         13

<210>  10494
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10494
aagatggcat tt                                                          12

<210>  10495
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10495
aagatggcat t                                                           11

<210>  10496
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10496
aagatggcat                                                             10

<210>  10497
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10497
aagatggca                                                              9

<210>  10498
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<400>  10498
aagatggc                                                               8

<210>  10499
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10499
agatggcatt tctag                                                       15

<210>  10500
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10500
agatggcatt tcta                                                        14

<210>  10501
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10501
agatggcatt tct                                                         13

<210>  10502
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5-methyl

<400>  10502
agatggcatt tc                                                          12

<210>  10503
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10503
agatggcatt t                                                           11

<210>  10504
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10504
agatggcatt                                                             10

<210>  10505
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10505
agatggcat                                                              9

<210>  10506
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<400>  10506
agatggca                                                               8

<210>  10507
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  bicyclic nucleic acid (BNA)

<400>  10507
ctccaacatc aaggaagatg gcatttctag                                       30

<210>  10508
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<400>  10508
ctccaacatc aaggaagatg gcatttcta                                        29

<210>  10509
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  10509
ctccaacatc aaggaagatg gcatttct                                         28

<210>  10510
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10510
ctccaacatc aaggaagatg gcatttc                                          27

<210>  10511
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10511
ctccaacatc aaggaagatg gcattt                                           26

<210>  10512
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10512
ctccaacatc aaggaagatg gcatt                                            25

<210>  10513
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10513
ctccaacatc aaggaagatg gcat                                             24

<210>  10514
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10514
ctccaacatc aaggaagatg gca                                              23

<210>  10515
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10515
ctccaacatc aaggaagatg gc                                               22

<210>  10516
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10516
ctccaacatc aaggaagatg g                                                21

<210>  10517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10517
ctccaacatc aaggaagatg                                                  20

<210>  10518
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10518
ctccaacatc aaggaagat                                                   19

<210>  10519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10519
ctccaacatc aaggaaga                                                    18

<210>  10520
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10520
ctccaacatc aaggaag                                                     17

<210>  10521
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  10521
tccaacatca aggaagatgg catttctag                                        29

<210>  10522
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  10522
tccaacatca aggaagatgg catttcta                                         28

<210>  10523
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  10523
tccaacatca aggaagatgg catttct                                          27

<210>  10524
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  5-methyl

<400>  10524
tccaacatca aggaagatgg catttc                                           26

<210>  10525
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  10525
tccaacatca aggaagatgg cattt                                            25

<210>  10526
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  10526
tccaacatca aggaagatgg catt                                             24

<210>  10527
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  10527
tccaacatca aggaagatgg cat                                              23

<210>  10528
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  10528
tccaacatca aggaagatgg ca                                               22

<210>  10529
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<400>  10529
tccaacatca aggaagatgg c                                                21

<210>  10530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10530
tccaacatca aggaagatgg                                                  20

<210>  10531
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10531
tccaacatca aggaagatg                                                   19

<210>  10532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10532
tccaacatca aggaagat                                                    18

<210>  10533
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10533
tccaacatca aggaaga                                                     17

<210>  10534
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<400>  10534
tccaacatca aggaag                                                      16

<210>  10535
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  bicyclic nucleic acid (BNA)

<400>  10535
ccaacatcaa ggaagatggc atttctag                                         28

<210>  10536
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10536
ccaacatcaa ggaagatggc atttcta                                          27

<210>  10537
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10537
ccaacatcaa ggaagatggc atttct                                           26

<210>  10538
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10538
ccaacatcaa ggaagatggc atttc                                            25

<210>  10539
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10539
ccaacatcaa ggaagatggc attt                                             24

<210>  10540
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10540
ccaacatcaa ggaagatggc att                                              23

<210>  10541
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10541
ccaacatcaa ggaagatggc at                                               22

<210>  10542
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10542
ccaacatcaa ggaagatggc a                                                21

<210>  10543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10543
ccaacatcaa ggaagatggc                                                  20

<210>  10544
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10544
ccaacatcaa ggaagatgg                                                   19

<210>  10545
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10545
ccaacatcaa ggaagatg                                                    18

<210>  10546
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10546
ccaacatcaa ggaagat                                                     17

<210>  10547
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10547
ccaacatcaa ggaaga                                                      16

<210>  10548
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10548
ccaacatcaa ggaag                                                       15

<210>  10549
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  bicyclic nucleic acid (BNA)

<400>  10549
caacatcaag gaagatggca tttctag                                          27

<210>  10550
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<400>  10550
caacatcaag gaagatggca tttcta                                           26

<210>  10551
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<400>  10551
caacatcaag gaagatggca tttct                                            25

<210>  10552
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10552
caacatcaag gaagatggca tttc                                             24

<210>  10553
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10553
caacatcaag gaagatggca ttt                                              23

<210>  10554
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10554
caacatcaag gaagatggca tt                                               22

<210>  10555
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10555
caacatcaag gaagatggca t                                                21

<210>  10556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10556
caacatcaag gaagatggca                                                  20

<210>  10557
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10557
caacatcaag gaagatggc                                                   19

<210>  10558
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10558
caacatcaag gaagatgg                                                    18

<210>  10559
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10559
caacatcaag gaagatg                                                     17

<210>  10560
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10560
caacatcaag gaagat                                                      16

<210>  10561
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10561
caacatcaag gaaga                                                       15

<210>  10562
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10562
caacatcaag gaag                                                        14

<210>  10563
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  10563
aacatcaagg aagatggcat ttctag                                           26

<210>  10564
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  10564
aacatcaagg aagatggcat ttcta                                            25

<210>  10565
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  10565
aacatcaagg aagatggcat ttct                                             24

<210>  10566
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<400>  10566
aacatcaagg aagatggcat ttc                                              23

<210>  10567
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10567
aacatcaagg aagatggcat tt                                               22

<210>  10568
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10568
aacatcaagg aagatggcat t                                                21

<210>  10569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10569
aacatcaagg aagatggcat                                                  20

<210>  10570
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10570
aacatcaagg aagatggca                                                   19

<210>  10571
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10571
aacatcaagg aagatggc                                                    18

<210>  10572
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10572
aacatcaagg aagatgg                                                     17

<210>  10573
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10573
aacatcaagg aagatg                                                      16

<210>  10574
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10574
aacatcaagg aagat                                                       15

<210>  10575
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10575
aacatcaagg aaga                                                        14

<210>  10576
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5-methyl

<400>  10576
aacatcaagg aag                                                         13

<210>  10577
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  10577
acatcaagga agatggcatt tctag                                            25

<210>  10578
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  10578
acatcaagga agatggcatt tcta                                             24

<210>  10579
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  10579
acatcaagga agatggcatt tct                                              23

<210>  10580
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<400>  10580
acatcaagga agatggcatt tc                                               22

<210>  10581
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10581
acatcaagga agatggcatt t                                                21

<210>  10582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10582
acatcaagga agatggcatt                                                  20

<210>  10583
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10583
acatcaagga agatggcat                                                   19

<210>  10584
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10584
acatcaagga agatggca                                                    18

<210>  10585
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<400>  10585
acatcaagga agatggc                                                     17

<210>  10586
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  10586
acatcaagga agatgg                                                      16

<210>  10587
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  10587
acatcaagga agatg                                                       15

<210>  10588
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  10588
acatcaagga agat                                                        14

<210>  10589
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  10589
acatcaagga aga                                                         13

<210>  10590
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5-methyl

<400>  10590
acatcaagga ag                                                          12

<210>  10591
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  bicyclic nucleic acid (BNA)

<400>  10591
catcaaggaa gatggcattt ctag                                             24

<210>  10592
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<400>  10592
catcaaggaa gatggcattt cta                                              23

<210>  10593
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  10593
catcaaggaa gatggcattt ct                                               22

<210>  10594
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<400>  10594
catcaaggaa gatggcattt c                                                21

<210>  10595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  10595
catcaaggaa gatggcattt                                                  20

<210>  10596
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10596
catcaaggaa gatggcatt                                                   19

<210>  10597
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  10597
catcaaggaa gatggcat                                                    18

<210>  10598
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10598
catcaaggaa gatggca                                                     17

<210>  10599
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10599
catcaaggaa gatggc                                                      16

<210>  10600
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10600
catcaaggaa gatgg                                                       15

<210>  10601
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10601
catcaaggaa gatg                                                        14

<210>  10602
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10602
catcaaggaa gat                                                         13

<210>  10603
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10603
catcaaggaa ga                                                          12

<210>  10604
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10604
catcaaggaa g                                                           11

<210>  10605
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  10605
atcaaggaag atggcatttc tag                                              23

<210>  10606
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  10606
atcaaggaag atggcatttc ta                                               22

<210>  10607
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  10607
atcaaggaag atggcatttc t                                                21

<210>  10608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5-methyl

<400>  10608
atcaaggaag atggcatttc                                                  20

<210>  10609
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10609
atcaaggaag atggcattt                                                   19

<210>  10610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10610
atcaaggaag atggcatt                                                    18

<210>  10611
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10611
atcaaggaag atggcat                                                     17

<210>  10612
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10612
atcaaggaag atggca                                                      16

<210>  10613
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5-methyl

<400>  10613
atcaaggaag atggc                                                       15

<210>  10614
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10614
atcaaggaag atgg                                                        14

<210>  10615
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10615
atcaaggaag atg                                                         13

<210>  10616
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10616
atcaaggaag at                                                          12

<210>  10617
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10617
atcaaggaag a                                                           11

<210>  10618
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5-methyl

<400>  10618
atcaaggaag                                                             10

<210>  10619
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  10619
gguaaguucu guccaagc                                                    18

<210>  10620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10620
gguaaguucu guccaagc                                                    18

<210>  10621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10621
gguaaguucu guccaagc                                                    18

<210>  10622
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10622
gguaaguucu guccaagc                                                    18

<210>  10623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10623
gguaaguucu guccaagc                                                    18

<210>  10624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10624
gguaaguucu guccaagc                                                    18

<210>  10625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10625
gguaaguucu guccaagc                                                    18

<210>  10626
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10626
guaaguucug uccaagcc                                                    18

<210>  10627
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10627
guaaguucug uccaagcc                                                    18

<210>  10628
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10628
guaaguucug uccaagcc                                                    18

<210>  10629
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10629
guaaguucug uccaagcc                                                    18

<210>  10630
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10630
guaaguucug uccaagcc                                                    18

<210>  10631
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10631
guaaguucug uccaagcc                                                    18

<210>  10632
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  10632
guaaguucug uccaagcc                                                    18

<210>  10633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  10633
agucgguaag uucugucc                                                    18

<210>  10634
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  10634
agucgguaag uucugucc                                                    18

<210>  10635
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10635
agucgguaag uucugucc                                                    18

<210>  10636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10636
agucgguaag uucugucc                                                    18

<210>  10637
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10637
agucgguaag uucugucc                                                    18

<210>  10638
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10638
agucgguaag uucugucc                                                    18

<210>  10639
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10639
agucgguaag uucugucc                                                    18

<210>  10640
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10640
agucgguaag uucugucc                                                    18

<210>  10641
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  10641
cuguccaagc ccgguuga                                                    18

<210>  10642
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10642
cuguccaagc ccgguuga                                                    18

<210>  10643
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10643
cuguccaagc ccgguuga                                                    18

<210>  10644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10644
cuguccaagc ccgguuga                                                    18

<210>  10645
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10645
cuguccaagc ccgguuga                                                    18

<210>  10646
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10646
cuguccaagc ccgguuga                                                    18

<210>  10647
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10647
cuguccaagc ccgguuga                                                    18

<210>  10648
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10648
cuguccaagc ccgguuga                                                    18

<210>  10649
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10649
cuguccaagc ccgguuga                                                    18

<210>  10650
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10650
cuguccaagc ccgguuga                                                    18

<210>  10651
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10651
gguaaguucu guccaagc                                                    18

<210>  10652
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10652
gguaaguucu guccaagc                                                    18

<210>  10653
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10653
gguaaguucu guccaagc                                                    18

<210>  10654
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10654
gguaaguucu guccaagc                                                    18

<210>  10655
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10655
gguaaguucu guccaagc                                                    18

<210>  10656
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10656
gguaaguucu guccaagc                                                    18

<210>  10657
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10657
gguaaguucu guccaagc                                                    18

<210>  10658
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10658
gguaaguucu guccaagc                                                    18

<210>  10659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10659
gguaaguucu guccaagc                                                    18

<210>  10660
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10660
gguaaguucu guccaagc                                                    18

<210>  10661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10661
gguaaguucu guccaagc                                                    18

<210>  10662
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10662
gguaaguucu guccaagc                                                    18

<210>  10663
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10663
gguaaguucu guccaagc                                                    18

<210>  10664
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10664
gguaaguucu guccaagc                                                    18

<210>  10665
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10665
gguaaguucu guccaagc                                                    18

<210>  10666
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10666
gguaaguucu guccaagc                                                    18

<210>  10667
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10667
gguaaguucu guccaagc                                                    18

<210>  10668
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10668
gguaaguucu guccaagc                                                    18

<210>  10669
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10669
gguaaguucu guccaagc                                                    18

<210>  10670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10670
gguaaguucu guccaagc                                                    18

<210>  10671
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10671
gguaaguucu guccaagc                                                    18

<210>  10672
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10672
guaaguucug uccaagcc                                                    18

<210>  10673
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  10673
guaaguucug uccaagcc                                                    18

<210>  10674
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10674
guaaguucug uccaagcc                                                    18

<210>  10675
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10675
guaaguucug uccaagcc                                                    18

<210>  10676
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10676
guaaguucug uccaagcc                                                    18

<210>  10677
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10677
guaaguucug uccaagcc                                                    18

<210>  10678
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10678
guaaguucug uccaagcc                                                    18

<210>  10679
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10679
guaaguucug uccaagcc                                                    18

<210>  10680
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10680
guaaguucug uccaagcc                                                    18

<210>  10681
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10681
guaaguucug uccaagcc                                                    18

<210>  10682
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10682
guaaguucug uccaagcc                                                    18

<210>  10683
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10683
guaaguucug uccaagcc                                                    18

<210>  10684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10684
guaaguucug uccaagcc                                                    18

<210>  10685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10685
guaaguucug uccaagcc                                                    18

<210>  10686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10686
guaaguucug uccaagcc                                                    18

<210>  10687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10687
guaaguucug uccaagcc                                                    18

<210>  10688
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10688
guaaguucug uccaagcc                                                    18

<210>  10689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10689
guaaguucug uccaagcc                                                    18

<210>  10690
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10690
guaaguucug uccaagcc                                                    18

<210>  10691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10691
guaaguucug uccaagcc                                                    18

<210>  10692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10692
guaaguucug uccaagcc                                                    18

<210>  10693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10693
agucgguaag uucugucc                                                    18

<210>  10694
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  10694
agucgguaag uucugucc                                                    18

<210>  10695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10695
agucgguaag uucugucc                                                    18

<210>  10696
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10696
agucgguaag uucugucc                                                    18

<210>  10697
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10697
agucgguaag uucugucc                                                    18

<210>  10698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10698
agucgguaag uucugucc                                                    18

<210>  10699
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10699
agucgguaag uucugucc                                                    18

<210>  10700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10700
agucgguaag uucugucc                                                    18

<210>  10701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10701
agucgguaag uucugucc                                                    18

<210>  10702
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10702
agucgguaag uucugucc                                                    18

<210>  10703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10703
agucgguaag uucugucc                                                    18

<210>  10704
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10704
agucgguaag uucugucc                                                    18

<210>  10705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10705
agucgguaag uucugucc                                                    18

<210>  10706
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10706
agucgguaag uucugucc                                                    18

<210>  10707
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10707
agucgguaag uucugucc                                                    18

<210>  10708
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10708
agucgguaag uucugucc                                                    18

<210>  10709
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10709
agucgguaag uucugucc                                                    18

<210>  10710
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10710
agucgguaag uucugucc                                                    18

<210>  10711
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10711
agucgguaag uucugucc                                                    18

<210>  10712
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10712
agucgguaag uucugucc                                                    18

<210>  10713
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10713
agucgguaag uucugucc                                                    18

<210>  10714
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10714
agucgguaag uucugucc                                                    18

<210>  10715
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10715
agucgguaag uucugucc                                                    18

<210>  10716
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10716
agucgguaag uucugucc                                                    18

<210>  10717
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10717
agucgguaag uucugucc                                                    18

<210>  10718
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10718
agucgguaag uucugucc                                                    18

<210>  10719
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10719
agucgguaag uucugucc                                                    18

<210>  10720
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10720
agucgguaag uucugucc                                                    18

<210>  10721
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10721
cuguccaagc ccgguuga                                                    18

<210>  10722
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10722
cuguccaagc ccgguuga                                                    18

<210>  10723
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10723
cuguccaagc ccgguuga                                                    18

<210>  10724
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10724
cuguccaagc ccgguuga                                                    18

<210>  10725
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10725
cuguccaagc ccgguuga                                                    18

<210>  10726
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10726
cuguccaagc ccgguuga                                                    18

<210>  10727
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10727
cuguccaagc ccgguuga                                                    18

<210>  10728
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10728
cuguccaagc ccgguuga                                                    18

<210>  10729
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10729
cuguccaagc ccgguuga                                                    18

<210>  10730
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10730
cuguccaagc ccgguuga                                                    18

<210>  10731
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10731
cuguccaagc ccgguuga                                                    18

<210>  10732
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10732
cuguccaagc ccgguuga                                                    18

<210>  10733
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10733
cuguccaagc ccgguuga                                                    18

<210>  10734
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10734
cuguccaagc ccgguuga                                                    18

<210>  10735
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10735
cuguccaagc ccgguuga                                                    18

<210>  10736
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10736
cuguccaagc ccgguuga                                                    18

<210>  10737
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10737
cuguccaagc ccgguuga                                                    18

<210>  10738
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10738
cuguccaagc ccgguuga                                                    18

<210>  10739
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10739
cuguccaagc ccgguuga                                                    18

<210>  10740
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10740
cuguccaagc ccgguuga                                                    18

<210>  10741
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10741
cuguccaagc ccgguuga                                                    18

<210>  10742
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10742
cuguccaagc ccgguuga                                                    18

<210>  10743
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10743
cuguccaagc ccgguuga                                                    18

<210>  10744
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10744
cuguccaagc ccgguuga                                                    18

<210>  10745
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10745
cuguccaagc ccgguuga                                                    18

<210>  10746
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10746
cuguccaagc ccgguuga                                                    18

<210>  10747
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10747
cuguccaagc ccgguuga                                                    18

<210>  10748
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10748
cuguccaagc ccgguuga                                                    18

<210>  10749
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10749
cuguccaagc ccgguuga                                                    18

<210>  10750
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10750
cuguccaagc ccgguuga                                                    18

<210>  10751
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10751
cuguccaagc ccgguuga                                                    18

<210>  10752
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10752
cuguccaagc ccgguuga                                                    18

<210>  10753
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10753
cuguccaagc ccgguuga                                                    18

<210>  10754
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10754
cuguccaagc ccgguuga                                                    18

<210>  10755
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10755
cuguccaagc ccgguuga                                                    18

<210>  10756
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10756
cuguccaagc ccgguuga                                                    18

<210>  10757
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10757
cuguccaagc ccgguuga                                                    18

<210>  10758
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10758
cuguccaagc ccgguuga                                                    18

<210>  10759
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10759
cuguccaagc ccgguuga                                                    18

<210>  10760
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10760
cuguccaagc ccgguuga                                                    18

<210>  10761
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10761
cuguccaagc ccgguuga                                                    18

<210>  10762
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10762
cuguccaagc ccgguuga                                                    18

<210>  10763
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10763
cuguccaagc ccgguuga                                                    18

<210>  10764
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10764
cuguccaagc ccgguuga                                                    18

<210>  10765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10765
cuguccaagc ccgguuga                                                    18

<210>  10766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  10766
ucaaggaaga uggcauuucu                                                  20

<210>  10767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10767
ucaaggaaga uggcauuucu                                                  20

<210>  10768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10768
ucaaggaaga uggcauuucu                                                  20

<210>  10769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10769
ucaaggaaga uggcauuucu                                                  20

<210>  10770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10770
ucaaggaaga uggcauuucu                                                  20

<210>  10771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10771
ucaaggaaga uggcauuucu                                                  20

<210>  10772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10772
ucaaggaaga uggcauuucu                                                  20

<210>  10773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10773
ucaaggaaga uggcauuucu                                                  20

<210>  10774
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  10774
ucaaggaaga uggcauuucu ag                                               22

<210>  10775
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10775
ucaaggaaga uggcauuucu ag                                               22

<210>  10776
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10776
ucaaggaaga uggcauuucu ag                                               22

<210>  10777
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10777
ucaaggaaga uggcauuucu ag                                               22

<210>  10778
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10778
ucaaggaaga uggcauuucu ag                                               22

<210>  10779
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10779
ucaaggaaga uggcauuucu ag                                               22

<210>  10780
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10780
ucaaggaaga uggcauuucu ag                                               22

<210>  10781
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10781
ucaaggaaga uggcauuucu ag                                               22

<210>  10782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10782
ucaaggaaga uggcauuucu                                                  20

<210>  10783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10783
ucaaggaaga uggcauuucu                                                  20

<210>  10784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10784
ucaaggaaga uggcauuucu                                                  20

<210>  10785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10785
ucaaggaaga uggcauuucu                                                  20

<210>  10786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10786
ucaaggaaga uggcauuucu                                                  20

<210>  10787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10787
ucaaggaaga uggcauuucu                                                  20

<210>  10788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10788
ucaaggaaga uggcauuucu                                                  20

<210>  10789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10789
ucaaggaaga uggcauuucu                                                  20

<210>  10790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10790
ucaaggaaga uggcauuucu                                                  20

<210>  10791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10791
ucaaggaaga uggcauuucu                                                  20

<210>  10792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10792
ucaaggaaga uggcauuucu                                                  20

<210>  10793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10793
ucaaggaaga uggcauuucu                                                  20

<210>  10794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10794
ucaaggaaga uggcauuucu                                                  20

<210>  10795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10795
ucaaggaaga uggcauuucu                                                  20

<210>  10796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10796
ucaaggaaga uggcauuucu                                                  20

<210>  10797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10797
ucaaggaaga uggcauuucu                                                  20

<210>  10798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10798
ucaaggaaga uggcauuucu                                                  20

<210>  10799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10799
ucaaggaaga uggcauuucu                                                  20

<210>  10800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10800
ucaaggaaga uggcauuucu                                                  20

<210>  10801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10801
ucaaggaaga uggcauuucu                                                  20

<210>  10802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10802
ucaaggaaga uggcauuucu                                                  20

<210>  10803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10803
ucaaggaaga uggcauuucu                                                  20

<210>  10804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10804
ucaaggaaga uggcauuucu                                                  20

<210>  10805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10805
ucaaggaaga uggcauuucu                                                  20

<210>  10806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10806
ucaaggaaga uggcauuucu                                                  20

<210>  10807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10807
ucaaggaaga uggcauuucu                                                  20

<210>  10808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10808
ucaaggaaga uggcauuucu                                                  20

<210>  10809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10809
ucaaggaaga uggcauuucu                                                  20

<210>  10810
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10810
ucaaggaaga uggcauuucu ag                                               22

<210>  10811
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10811
ucaaggaaga uggcauuucu ag                                               22

<210>  10812
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10812
ucaaggaaga uggcauuucu ag                                               22

<210>  10813
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10813
ucaaggaaga uggcauuucu ag                                               22

<210>  10814
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10814
ucaaggaaga uggcauuucu ag                                               22

<210>  10815
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10815
ucaaggaaga uggcauuucu ag                                               22

<210>  10816
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10816
ucaaggaaga uggcauuucu ag                                               22

<210>  10817
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10817
ucaaggaaga uggcauuucu ag                                               22

<210>  10818
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10818
ucaaggaaga uggcauuucu ag                                               22

<210>  10819
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10819
ucaaggaaga uggcauuucu ag                                               22

<210>  10820
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10820
ucaaggaaga uggcauuucu ag                                               22

<210>  10821
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10821
ucaaggaaga uggcauuucu ag                                               22

<210>  10822
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10822
ucaaggaaga uggcauuucu ag                                               22

<210>  10823
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10823
ucaaggaaga uggcauuucu ag                                               22

<210>  10824
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10824
ucaaggaaga uggcauuucu ag                                               22

<210>  10825
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10825
ucaaggaaga uggcauuucu ag                                               22

<210>  10826
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10826
ucaaggaaga uggcauuucu ag                                               22

<210>  10827
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10827
ucaaggaaga uggcauuucu ag                                               22

<210>  10828
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10828
ucaaggaaga uggcauuucu ag                                               22

<210>  10829
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10829
ucaaggaaga uggcauuucu ag                                               22

<210>  10830
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10830
ucaaggaaga uggcauuucu ag                                               22

<210>  10831
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10831
ucaaggaaga uggcauuucu ag                                               22

<210>  10832
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10832
ucaaggaaga uggcauuucu ag                                               22

<210>  10833
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10833
ucaaggaaga uggcauuucu ag                                               22

<210>  10834
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10834
ucaaggaaga uggcauuucu ag                                               22

<210>  10835
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10835
ucaaggaaga uggcauuucu ag                                               22

<210>  10836
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10836
ucaaggaaga uggcauuucu ag                                               22

<210>  10837
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10837
ucaaggaaga uggcauuucu ag                                               22

<210>  10838
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10838
gguaaguucu guccaagc                                                    18

<210>  10839
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10839
gguaaguucu guccaagc                                                    18

<210>  10840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10840
gguaaguucu guccaagc                                                    18

<210>  10841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10841
gguaaguucu guccaagc                                                    18

<210>  10842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10842
gguaaguucu guccaagc                                                    18

<210>  10843
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10843
gguaaguucu guccaagc                                                    18

<210>  10844
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10844
gguaaguucu guccaagc                                                    18

<210>  10845
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10845
guaaguucug uccaagcc                                                    18

<210>  10846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10846
guaaguucug uccaagcc                                                    18

<210>  10847
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10847
guaaguucug uccaagcc                                                    18

<210>  10848
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10848
guaaguucug uccaagcc                                                    18

<210>  10849
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10849
guaaguucug uccaagcc                                                    18

<210>  10850
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10850
guaaguucug uccaagcc                                                    18

<210>  10851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  10851
guaaguucug uccaagcc                                                    18

<210>  10852
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10852
agucgguaag uucugucc                                                    18

<210>  10853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  10853
agucgguaag uucugucc                                                    18

<210>  10854
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10854
agucgguaag uucugucc                                                    18

<210>  10855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10855
agucgguaag uucugucc                                                    18

<210>  10856
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10856
agucgguaag uucugucc                                                    18

<210>  10857
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10857
agucgguaag uucugucc                                                    18

<210>  10858
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10858
agucgguaag uucugucc                                                    18

<210>  10859
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10859
agucgguaag uucugucc                                                    18

<210>  10860
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  10860
cuguccaagc ccgguuga                                                    18

<210>  10861
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10861
cuguccaagc ccgguuga                                                    18

<210>  10862
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10862
cuguccaagc ccgguuga                                                    18

<210>  10863
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10863
cuguccaagc ccgguuga                                                    18

<210>  10864
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10864
cuguccaagc ccgguuga                                                    18

<210>  10865
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10865
cuguccaagc ccgguuga                                                    18

<210>  10866
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10866
cuguccaagc ccgguuga                                                    18

<210>  10867
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10867
cuguccaagc ccgguuga                                                    18

<210>  10868
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10868
cuguccaagc ccgguuga                                                    18

<210>  10869
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10869
cuguccaagc ccgguuga                                                    18

<210>  10870
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10870
gguaaguucu guccaagc                                                    18

<210>  10871
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10871
gguaaguucu guccaagc                                                    18

<210>  10872
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10872
gguaaguucu guccaagc                                                    18

<210>  10873
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10873
gguaaguucu guccaagc                                                    18

<210>  10874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10874
gguaaguucu guccaagc                                                    18

<210>  10875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10875
gguaaguucu guccaagc                                                    18

<210>  10876
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10876
gguaaguucu guccaagc                                                    18

<210>  10877
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10877
gguaaguucu guccaagc                                                    18

<210>  10878
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10878
gguaaguucu guccaagc                                                    18

<210>  10879
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10879
gguaaguucu guccaagc                                                    18

<210>  10880
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10880
gguaaguucu guccaagc                                                    18

<210>  10881
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10881
gguaaguucu guccaagc                                                    18

<210>  10882
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10882
gguaaguucu guccaagc                                                    18

<210>  10883
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10883
gguaaguucu guccaagc                                                    18

<210>  10884
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10884
gguaaguucu guccaagc                                                    18

<210>  10885
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10885
gguaaguucu guccaagc                                                    18

<210>  10886
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10886
gguaaguucu guccaagc                                                    18

<210>  10887
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10887
gguaaguucu guccaagc                                                    18

<210>  10888
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10888
gguaaguucu guccaagc                                                    18

<210>  10889
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10889
gguaaguucu guccaagc                                                    18

<210>  10890
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  10890
gguaaguucu guccaagc                                                    18

<210>  10891
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10891
guaaguucug uccaagcc                                                    18

<210>  10892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10892
guaaguucug uccaagcc                                                    18

<210>  10893
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10893
guaaguucug uccaagcc                                                    18

<210>  10894
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10894
guaaguucug uccaagcc                                                    18

<210>  10895
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10895
guaaguucug uccaagcc                                                    18

<210>  10896
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10896
guaaguucug uccaagcc                                                    18

<210>  10897
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10897
guaaguucug uccaagcc                                                    18

<210>  10898
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10898
guaaguucug uccaagcc                                                    18

<210>  10899
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10899
guaaguucug uccaagcc                                                    18

<210>  10900
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10900
guaaguucug uccaagcc                                                    18

<210>  10901
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10901
guaaguucug uccaagcc                                                    18

<210>  10902
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10902
guaaguucug uccaagcc                                                    18

<210>  10903
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10903
guaaguucug uccaagcc                                                    18

<210>  10904
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10904
guaaguucug uccaagcc                                                    18

<210>  10905
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10905
guaaguucug uccaagcc                                                    18

<210>  10906
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10906
guaaguucug uccaagcc                                                    18

<210>  10907
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10907
guaaguucug uccaagcc                                                    18

<210>  10908
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10908
guaaguucug uccaagcc                                                    18

<210>  10909
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  10909
guaaguucug uccaagcc                                                    18

<210>  10910
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10910
guaaguucug uccaagcc                                                    18

<210>  10911
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10911
guaaguucug uccaagcc                                                    18

<210>  10912
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10912
agucgguaag uucugucc                                                    18

<210>  10913
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10913
agucgguaag uucugucc                                                    18

<210>  10914
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10914
agucgguaag uucugucc                                                    18

<210>  10915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10915
agucgguaag uucugucc                                                    18

<210>  10916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10916
agucgguaag uucugucc                                                    18

<210>  10917
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10917
agucgguaag uucugucc                                                    18

<210>  10918
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10918
agucgguaag uucugucc                                                    18

<210>  10919
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10919
agucgguaag uucugucc                                                    18

<210>  10920
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10920
agucgguaag uucugucc                                                    18

<210>  10921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10921
agucgguaag uucugucc                                                    18

<210>  10922
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10922
agucgguaag uucugucc                                                    18

<210>  10923
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10923
agucgguaag uucugucc                                                    18

<210>  10924
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10924
agucgguaag uucugucc                                                    18

<210>  10925
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10925
agucgguaag uucugucc                                                    18

<210>  10926
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10926
agucgguaag uucugucc                                                    18

<210>  10927
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10927
agucgguaag uucugucc                                                    18

<210>  10928
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10928
agucgguaag uucugucc                                                    18

<210>  10929
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10929
agucgguaag uucugucc                                                    18

<210>  10930
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10930
agucgguaag uucugucc                                                    18

<210>  10931
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10931
agucgguaag uucugucc                                                    18

<210>  10932
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10932
agucgguaag uucugucc                                                    18

<210>  10933
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10933
agucgguaag uucugucc                                                    18

<210>  10934
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10934
agucgguaag uucugucc                                                    18

<210>  10935
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  10935
agucgguaag uucugucc                                                    18

<210>  10936
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10936
agucgguaag uucugucc                                                    18

<210>  10937
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  10937
agucgguaag uucugucc                                                    18

<210>  10938
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10938
agucgguaag uucugucc                                                    18

<210>  10939
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10939
agucgguaag uucugucc                                                    18

<210>  10940
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10940
cuguccaagc ccgguuga                                                    18

<210>  10941
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10941
cuguccaagc ccgguuga                                                    18

<210>  10942
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10942
cuguccaagc ccgguuga                                                    18

<210>  10943
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10943
cuguccaagc ccgguuga                                                    18

<210>  10944
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10944
cuguccaagc ccgguuga                                                    18

<210>  10945
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10945
cuguccaagc ccgguuga                                                    18

<210>  10946
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10946
cuguccaagc ccgguuga                                                    18

<210>  10947
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10947
cuguccaagc ccgguuga                                                    18

<210>  10948
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10948
cuguccaagc ccgguuga                                                    18

<210>  10949
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10949
cuguccaagc ccgguuga                                                    18

<210>  10950
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10950
cuguccaagc ccgguuga                                                    18

<210>  10951
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10951
cuguccaagc ccgguuga                                                    18

<210>  10952
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10952
cuguccaagc ccgguuga                                                    18

<210>  10953
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10953
cuguccaagc ccgguuga                                                    18

<210>  10954
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  10954
cuguccaagc ccgguuga                                                    18

<210>  10955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10955
cuguccaagc ccgguuga                                                    18

<210>  10956
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10956
cuguccaagc ccgguuga                                                    18

<210>  10957
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10957
cuguccaagc ccgguuga                                                    18

<210>  10958
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10958
cuguccaagc ccgguuga                                                    18

<210>  10959
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10959
cuguccaagc ccgguuga                                                    18

<210>  10960
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10960
cuguccaagc ccgguuga                                                    18

<210>  10961
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10961
cuguccaagc ccgguuga                                                    18

<210>  10962
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10962
cuguccaagc ccgguuga                                                    18

<210>  10963
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10963
cuguccaagc ccgguuga                                                    18

<210>  10964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10964
cuguccaagc ccgguuga                                                    18

<210>  10965
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10965
cuguccaagc ccgguuga                                                    18

<210>  10966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10966
cuguccaagc ccgguuga                                                    18

<210>  10967
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10967
cuguccaagc ccgguuga                                                    18

<210>  10968
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10968
cuguccaagc ccgguuga                                                    18

<210>  10969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10969
cuguccaagc ccgguuga                                                    18

<210>  10970
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10970
cuguccaagc ccgguuga                                                    18

<210>  10971
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10971
cuguccaagc ccgguuga                                                    18

<210>  10972
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10972
cuguccaagc ccgguuga                                                    18

<210>  10973
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10973
cuguccaagc ccgguuga                                                    18

<210>  10974
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10974
cuguccaagc ccgguuga                                                    18

<210>  10975
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10975
cuguccaagc ccgguuga                                                    18

<210>  10976
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10976
cuguccaagc ccgguuga                                                    18

<210>  10977
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10977
cuguccaagc ccgguuga                                                    18

<210>  10978
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  10978
cuguccaagc ccgguuga                                                    18

<210>  10979
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10979
cuguccaagc ccgguuga                                                    18

<210>  10980
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10980
cuguccaagc ccgguuga                                                    18

<210>  10981
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  10981
cuguccaagc ccgguuga                                                    18

<210>  10982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10982
cuguccaagc ccgguuga                                                    18

<210>  10983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10983
cuguccaagc ccgguuga                                                    18

<210>  10984
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10984
cuguccaagc ccgguuga                                                    18

<210>  10985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  10985
ucaaggaaga uggcauuucu                                                  20

<210>  10986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10986
ucaaggaaga uggcauuucu                                                  20

<210>  10987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10987
ucaaggaaga uggcauuucu                                                  20

<210>  10988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10988
ucaaggaaga uggcauuucu                                                  20

<210>  10989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10989
ucaaggaaga uggcauuucu                                                  20

<210>  10990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10990
ucaaggaaga uggcauuucu                                                  20

<210>  10991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10991
ucaaggaaga uggcauuucu                                                  20

<210>  10992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  10992
ucaaggaaga uggcauuucu                                                  20

<210>  10993
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  10993
ucaaggaaga uggcauuucu ag                                               22

<210>  10994
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  10994
ucaaggaaga uggcauuucu ag                                               22

<210>  10995
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  10995
ucaaggaaga uggcauuucu ag                                               22

<210>  10996
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  10996
ucaaggaaga uggcauuucu ag                                               22

<210>  10997
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  10997
ucaaggaaga uggcauuucu ag                                               22

<210>  10998
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  10998
ucaaggaaga uggcauuucu ag                                               22

<210>  10999
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  10999
ucaaggaaga uggcauuucu ag                                               22

<210>  11000
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11000
ucaaggaaga uggcauuucu ag                                               22

<210>  11001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11001
ucaaggaaga uggcauuucu                                                  20

<210>  11002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11002
ucaaggaaga uggcauuucu                                                  20

<210>  11003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11003
ucaaggaaga uggcauuucu                                                  20

<210>  11004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11004
ucaaggaaga uggcauuucu                                                  20

<210>  11005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11005
ucaaggaaga uggcauuucu                                                  20

<210>  11006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11006
ucaaggaaga uggcauuucu                                                  20

<210>  11007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11007
ucaaggaaga uggcauuucu                                                  20

<210>  11008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11008
ucaaggaaga uggcauuucu                                                  20

<210>  11009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11009
ucaaggaaga uggcauuucu                                                  20

<210>  11010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11010
ucaaggaaga uggcauuucu                                                  20

<210>  11011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11011
ucaaggaaga uggcauuucu                                                  20

<210>  11012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11012
ucaaggaaga uggcauuucu                                                  20

<210>  11013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11013
ucaaggaaga uggcauuucu                                                  20

<210>  11014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11014
ucaaggaaga uggcauuucu                                                  20

<210>  11015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11015
ucaaggaaga uggcauuucu                                                  20

<210>  11016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11016
ucaaggaaga uggcauuucu                                                  20

<210>  11017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11017
ucaaggaaga uggcauuucu                                                  20

<210>  11018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11018
ucaaggaaga uggcauuucu                                                  20

<210>  11019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11019
ucaaggaaga uggcauuucu                                                  20

<210>  11020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11020
ucaaggaaga uggcauuucu                                                  20

<210>  11021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11021
ucaaggaaga uggcauuucu                                                  20

<210>  11022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11022
ucaaggaaga uggcauuucu                                                  20

<210>  11023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11023
ucaaggaaga uggcauuucu                                                  20

<210>  11024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11024
ucaaggaaga uggcauuucu                                                  20

<210>  11025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11025
ucaaggaaga uggcauuucu                                                  20

<210>  11026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11026
ucaaggaaga uggcauuucu                                                  20

<210>  11027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11027
ucaaggaaga uggcauuucu                                                  20

<210>  11028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11028
ucaaggaaga uggcauuucu                                                  20

<210>  11029
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11029
ucaaggaaga uggcauuucu ag                                               22

<210>  11030
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11030
ucaaggaaga uggcauuucu ag                                               22

<210>  11031
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11031
ucaaggaaga uggcauuucu ag                                               22

<210>  11032
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11032
ucaaggaaga uggcauuucu ag                                               22

<210>  11033
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11033
ucaaggaaga uggcauuucu ag                                               22

<210>  11034
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11034
ucaaggaaga uggcauuucu ag                                               22

<210>  11035
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11035
ucaaggaaga uggcauuucu ag                                               22

<210>  11036
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11036
ucaaggaaga uggcauuucu ag                                               22

<210>  11037
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11037
ucaaggaaga uggcauuucu ag                                               22

<210>  11038
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11038
ucaaggaaga uggcauuucu ag                                               22

<210>  11039
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11039
ucaaggaaga uggcauuucu ag                                               22

<210>  11040
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11040
ucaaggaaga uggcauuucu ag                                               22

<210>  11041
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11041
ucaaggaaga uggcauuucu ag                                               22

<210>  11042
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11042
ucaaggaaga uggcauuucu ag                                               22

<210>  11043
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11043
ucaaggaaga uggcauuucu ag                                               22

<210>  11044
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11044
ucaaggaaga uggcauuucu ag                                               22

<210>  11045
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11045
ucaaggaaga uggcauuucu ag                                               22

<210>  11046
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11046
ucaaggaaga uggcauuucu ag                                               22

<210>  11047
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11047
ucaaggaaga uggcauuucu ag                                               22

<210>  11048
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11048
ucaaggaaga uggcauuucu ag                                               22

<210>  11049
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11049
ucaaggaaga uggcauuucu ag                                               22

<210>  11050
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11050
ucaaggaaga uggcauuucu ag                                               22

<210>  11051
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11051
ucaaggaaga uggcauuucu ag                                               22

<210>  11052
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11052
ucaaggaaga uggcauuucu ag                                               22

<210>  11053
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11053
ucaaggaaga uggcauuucu ag                                               22

<210>  11054
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11054
ucaaggaaga uggcauuucu ag                                               22

<210>  11055
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11055
ucaaggaaga uggcauuucu ag                                               22

<210>  11056
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11056
ucaaggaaga uggcauuucu ag                                               22

<210>  11057
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  11057
ggtaagttct gtccaagc                                                    18

<210>  11058
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11058
ggtaagttct gtccaagc                                                    18

<210>  11059
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11059
ggtaagttct gtccaagc                                                    18

<210>  11060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11060
ggtaagttct gtccaagc                                                    18

<210>  11061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11061
ggtaagttct gtccaagc                                                    18

<210>  11062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11062
ggtaagttct gtccaagc                                                    18

<210>  11063
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11063
ggtaagttct gtccaagc                                                    18

<210>  11064
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11064
gtaagttctg tccaagcc                                                    18

<210>  11065
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11065
gtaagttctg tccaagcc                                                    18

<210>  11066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11066
gtaagttctg tccaagcc                                                    18

<210>  11067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11067
gtaagttctg tccaagcc                                                    18

<210>  11068
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11068
gtaagttctg tccaagcc                                                    18

<210>  11069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11069
gtaagttctg tccaagcc                                                    18

<210>  11070
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11070
gtaagttctg tccaagcc                                                    18

<210>  11071
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  11071
agtcggtaag ttctgtcc                                                    18

<210>  11072
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  11072
agtcggtaag ttctgtcc                                                    18

<210>  11073
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11073
agtcggtaag ttctgtcc                                                    18

<210>  11074
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11074
agtcggtaag ttctgtcc                                                    18

<210>  11075
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11075
agtcggtaag ttctgtcc                                                    18

<210>  11076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11076
agtcggtaag ttctgtcc                                                    18

<210>  11077
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11077
agtcggtaag ttctgtcc                                                    18

<210>  11078
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11078
agtcggtaag ttctgtcc                                                    18

<210>  11079
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  11079
ctgtccaagc ccggttga                                                    18

<210>  11080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11080
ctgtccaagc ccggttga                                                    18

<210>  11081
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11081
ctgtccaagc ccggttga                                                    18

<210>  11082
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11082
ctgtccaagc ccggttga                                                    18

<210>  11083
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11083
ctgtccaagc ccggttga                                                    18

<210>  11084
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11084
ctgtccaagc ccggttga                                                    18

<210>  11085
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11085
ctgtccaagc ccggttga                                                    18

<210>  11086
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11086
ctgtccaagc ccggttga                                                    18

<210>  11087
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11087
ctgtccaagc ccggttga                                                    18

<210>  11088
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11088
ctgtccaagc ccggttga                                                    18

<210>  11089
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11089
ggtaagttct gtccaagc                                                    18

<210>  11090
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11090
ggtaagttct gtccaagc                                                    18

<210>  11091
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11091
ggtaagttct gtccaagc                                                    18

<210>  11092
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11092
ggtaagttct gtccaagc                                                    18

<210>  11093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11093
ggtaagttct gtccaagc                                                    18

<210>  11094
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11094
ggtaagttct gtccaagc                                                    18

<210>  11095
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11095
ggtaagttct gtccaagc                                                    18

<210>  11096
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11096
ggtaagttct gtccaagc                                                    18

<210>  11097
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11097
ggtaagttct gtccaagc                                                    18

<210>  11098
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11098
ggtaagttct gtccaagc                                                    18

<210>  11099
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11099
ggtaagttct gtccaagc                                                    18

<210>  11100
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11100
ggtaagttct gtccaagc                                                    18

<210>  11101
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11101
ggtaagttct gtccaagc                                                    18

<210>  11102
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11102
ggtaagttct gtccaagc                                                    18

<210>  11103
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11103
ggtaagttct gtccaagc                                                    18

<210>  11104
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11104
ggtaagttct gtccaagc                                                    18

<210>  11105
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11105
ggtaagttct gtccaagc                                                    18

<210>  11106
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11106
ggtaagttct gtccaagc                                                    18

<210>  11107
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11107
ggtaagttct gtccaagc                                                    18

<210>  11108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11108
ggtaagttct gtccaagc                                                    18

<210>  11109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11109
ggtaagttct gtccaagc                                                    18

<210>  11110
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11110
gtaagttctg tccaagcc                                                    18

<210>  11111
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11111
gtaagttctg tccaagcc                                                    18

<210>  11112
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11112
gtaagttctg tccaagcc                                                    18

<210>  11113
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11113
gtaagttctg tccaagcc                                                    18

<210>  11114
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11114
gtaagttctg tccaagcc                                                    18

<210>  11115
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11115
gtaagttctg tccaagcc                                                    18

<210>  11116
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11116
gtaagttctg tccaagcc                                                    18

<210>  11117
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11117
gtaagttctg tccaagcc                                                    18

<210>  11118
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11118
gtaagttctg tccaagcc                                                    18

<210>  11119
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11119
gtaagttctg tccaagcc                                                    18

<210>  11120
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11120
gtaagttctg tccaagcc                                                    18

<210>  11121
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11121
gtaagttctg tccaagcc                                                    18

<210>  11122
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11122
gtaagttctg tccaagcc                                                    18

<210>  11123
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11123
gtaagttctg tccaagcc                                                    18

<210>  11124
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11124
gtaagttctg tccaagcc                                                    18

<210>  11125
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11125
gtaagttctg tccaagcc                                                    18

<210>  11126
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11126
gtaagttctg tccaagcc                                                    18

<210>  11127
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11127
gtaagttctg tccaagcc                                                    18

<210>  11128
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11128
gtaagttctg tccaagcc                                                    18

<210>  11129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11129
gtaagttctg tccaagcc                                                    18

<210>  11130
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11130
gtaagttctg tccaagcc                                                    18

<210>  11131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11131
agtcggtaag ttctgtcc                                                    18

<210>  11132
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  11132
agtcggtaag ttctgtcc                                                    18

<210>  11133
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11133
agtcggtaag ttctgtcc                                                    18

<210>  11134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11134
agtcggtaag ttctgtcc                                                    18

<210>  11135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11135
agtcggtaag ttctgtcc                                                    18

<210>  11136
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11136
agtcggtaag ttctgtcc                                                    18

<210>  11137
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11137
agtcggtaag ttctgtcc                                                    18

<210>  11138
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11138
agtcggtaag ttctgtcc                                                    18

<210>  11139
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11139
agtcggtaag ttctgtcc                                                    18

<210>  11140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11140
agtcggtaag ttctgtcc                                                    18

<210>  11141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11141
agtcggtaag ttctgtcc                                                    18

<210>  11142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11142
agtcggtaag ttctgtcc                                                    18

<210>  11143
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11143
agtcggtaag ttctgtcc                                                    18

<210>  11144
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11144
agtcggtaag ttctgtcc                                                    18

<210>  11145
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11145
agtcggtaag ttctgtcc                                                    18

<210>  11146
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11146
agtcggtaag ttctgtcc                                                    18

<210>  11147
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11147
agtcggtaag ttctgtcc                                                    18

<210>  11148
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11148
agtcggtaag ttctgtcc                                                    18

<210>  11149
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11149
agtcggtaag ttctgtcc                                                    18

<210>  11150
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11150
agtcggtaag ttctgtcc                                                    18

<210>  11151
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11151
agtcggtaag ttctgtcc                                                    18

<210>  11152
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11152
agtcggtaag ttctgtcc                                                    18

<210>  11153
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11153
agtcggtaag ttctgtcc                                                    18

<210>  11154
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11154
agtcggtaag ttctgtcc                                                    18

<210>  11155
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11155
agtcggtaag ttctgtcc                                                    18

<210>  11156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11156
agtcggtaag ttctgtcc                                                    18

<210>  11157
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11157
agtcggtaag ttctgtcc                                                    18

<210>  11158
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11158
agtcggtaag ttctgtcc                                                    18

<210>  11159
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11159
ctgtccaagc ccggttga                                                    18

<210>  11160
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11160
ctgtccaagc ccggttga                                                    18

<210>  11161
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11161
ctgtccaagc ccggttga                                                    18

<210>  11162
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11162
ctgtccaagc ccggttga                                                    18

<210>  11163
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11163
ctgtccaagc ccggttga                                                    18

<210>  11164
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11164
ctgtccaagc ccggttga                                                    18

<210>  11165
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11165
ctgtccaagc ccggttga                                                    18

<210>  11166
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11166
ctgtccaagc ccggttga                                                    18

<210>  11167
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11167
ctgtccaagc ccggttga                                                    18

<210>  11168
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11168
ctgtccaagc ccggttga                                                    18

<210>  11169
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11169
ctgtccaagc ccggttga                                                    18

<210>  11170
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11170
ctgtccaagc ccggttga                                                    18

<210>  11171
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11171
ctgtccaagc ccggttga                                                    18

<210>  11172
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11172
ctgtccaagc ccggttga                                                    18

<210>  11173
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11173
ctgtccaagc ccggttga                                                    18

<210>  11174
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11174
ctgtccaagc ccggttga                                                    18

<210>  11175
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11175
ctgtccaagc ccggttga                                                    18

<210>  11176
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11176
ctgtccaagc ccggttga                                                    18

<210>  11177
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11177
ctgtccaagc ccggttga                                                    18

<210>  11178
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11178
ctgtccaagc ccggttga                                                    18

<210>  11179
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11179
ctgtccaagc ccggttga                                                    18

<210>  11180
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11180
ctgtccaagc ccggttga                                                    18

<210>  11181
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11181
ctgtccaagc ccggttga                                                    18

<210>  11182
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11182
ctgtccaagc ccggttga                                                    18

<210>  11183
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11183
ctgtccaagc ccggttga                                                    18

<210>  11184
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11184
ctgtccaagc ccggttga                                                    18

<210>  11185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11185
ctgtccaagc ccggttga                                                    18

<210>  11186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11186
ctgtccaagc ccggttga                                                    18

<210>  11187
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11187
ctgtccaagc ccggttga                                                    18

<210>  11188
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11188
ctgtccaagc ccggttga                                                    18

<210>  11189
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11189
ctgtccaagc ccggttga                                                    18

<210>  11190
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11190
ctgtccaagc ccggttga                                                    18

<210>  11191
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11191
ctgtccaagc ccggttga                                                    18

<210>  11192
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11192
ctgtccaagc ccggttga                                                    18

<210>  11193
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11193
ctgtccaagc ccggttga                                                    18

<210>  11194
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11194
ctgtccaagc ccggttga                                                    18

<210>  11195
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11195
ctgtccaagc ccggttga                                                    18

<210>  11196
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11196
ctgtccaagc ccggttga                                                    18

<210>  11197
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11197
ctgtccaagc ccggttga                                                    18

<210>  11198
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11198
ctgtccaagc ccggttga                                                    18

<210>  11199
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11199
ctgtccaagc ccggttga                                                    18

<210>  11200
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11200
ctgtccaagc ccggttga                                                    18

<210>  11201
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11201
ctgtccaagc ccggttga                                                    18

<210>  11202
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11202
ctgtccaagc ccggttga                                                    18

<210>  11203
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11203
ctgtccaagc ccggttga                                                    18

<210>  11204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  11204
tcaaggaaga tggcatttct                                                  20

<210>  11205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11205
tcaaggaaga tggcatttct                                                  20

<210>  11206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11206
tcaaggaaga tggcatttct                                                  20

<210>  11207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11207
tcaaggaaga tggcatttct                                                  20

<210>  11208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11208
tcaaggaaga tggcatttct                                                  20

<210>  11209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11209
tcaaggaaga tggcatttct                                                  20

<210>  11210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11210
tcaaggaaga tggcatttct                                                  20

<210>  11211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11211
tcaaggaaga tggcatttct                                                  20

<210>  11212
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  11212
tcaaggaaga tggcatttct ag                                               22

<210>  11213
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11213
tcaaggaaga tggcatttct ag                                               22

<210>  11214
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11214
tcaaggaaga tggcatttct ag                                               22

<210>  11215
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11215
tcaaggaaga tggcatttct ag                                               22

<210>  11216
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11216
tcaaggaaga tggcatttct ag                                               22

<210>  11217
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11217
tcaaggaaga tggcatttct ag                                               22

<210>  11218
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11218
tcaaggaaga tggcatttct ag                                               22

<210>  11219
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11219
tcaaggaaga tggcatttct ag                                               22

<210>  11220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11220
tcaaggaaga tggcatttct                                                  20

<210>  11221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11221
tcaaggaaga tggcatttct                                                  20

<210>  11222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11222
tcaaggaaga tggcatttct                                                  20

<210>  11223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11223
tcaaggaaga tggcatttct                                                  20

<210>  11224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11224
tcaaggaaga tggcatttct                                                  20

<210>  11225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11225
tcaaggaaga tggcatttct                                                  20

<210>  11226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11226
tcaaggaaga tggcatttct                                                  20

<210>  11227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11227
tcaaggaaga tggcatttct                                                  20

<210>  11228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11228
tcaaggaaga tggcatttct                                                  20

<210>  11229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11229
tcaaggaaga tggcatttct                                                  20

<210>  11230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11230
tcaaggaaga tggcatttct                                                  20

<210>  11231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11231
tcaaggaaga tggcatttct                                                  20

<210>  11232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11232
tcaaggaaga tggcatttct                                                  20

<210>  11233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11233
tcaaggaaga tggcatttct                                                  20

<210>  11234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11234
tcaaggaaga tggcatttct                                                  20

<210>  11235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11235
tcaaggaaga tggcatttct                                                  20

<210>  11236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11236
tcaaggaaga tggcatttct                                                  20

<210>  11237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11237
tcaaggaaga tggcatttct                                                  20

<210>  11238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11238
tcaaggaaga tggcatttct                                                  20

<210>  11239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11239
tcaaggaaga tggcatttct                                                  20

<210>  11240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11240
tcaaggaaga tggcatttct                                                  20

<210>  11241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11241
tcaaggaaga tggcatttct                                                  20

<210>  11242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11242
tcaaggaaga tggcatttct                                                  20

<210>  11243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11243
tcaaggaaga tggcatttct                                                  20

<210>  11244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11244
tcaaggaaga tggcatttct                                                  20

<210>  11245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11245
tcaaggaaga tggcatttct                                                  20

<210>  11246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11246
tcaaggaaga tggcatttct                                                  20

<210>  11247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11247
tcaaggaaga tggcatttct                                                  20

<210>  11248
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11248
tcaaggaaga tggcatttct ag                                               22

<210>  11249
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11249
tcaaggaaga tggcatttct ag                                               22

<210>  11250
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11250
tcaaggaaga tggcatttct ag                                               22

<210>  11251
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11251
tcaaggaaga tggcatttct ag                                               22

<210>  11252
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11252
tcaaggaaga tggcatttct ag                                               22

<210>  11253
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11253
tcaaggaaga tggcatttct ag                                               22

<210>  11254
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11254
tcaaggaaga tggcatttct ag                                               22

<210>  11255
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11255
tcaaggaaga tggcatttct ag                                               22

<210>  11256
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11256
tcaaggaaga tggcatttct ag                                               22

<210>  11257
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11257
tcaaggaaga tggcatttct ag                                               22

<210>  11258
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11258
tcaaggaaga tggcatttct ag                                               22

<210>  11259
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11259
tcaaggaaga tggcatttct ag                                               22

<210>  11260
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11260
tcaaggaaga tggcatttct ag                                               22

<210>  11261
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11261
tcaaggaaga tggcatttct ag                                               22

<210>  11262
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11262
tcaaggaaga tggcatttct ag                                               22

<210>  11263
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11263
tcaaggaaga tggcatttct ag                                               22

<210>  11264
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11264
tcaaggaaga tggcatttct ag                                               22

<210>  11265
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11265
tcaaggaaga tggcatttct ag                                               22

<210>  11266
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11266
tcaaggaaga tggcatttct ag                                               22

<210>  11267
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11267
tcaaggaaga tggcatttct ag                                               22

<210>  11268
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11268
tcaaggaaga tggcatttct ag                                               22

<210>  11269
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11269
tcaaggaaga tggcatttct ag                                               22

<210>  11270
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11270
tcaaggaaga tggcatttct ag                                               22

<210>  11271
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11271
tcaaggaaga tggcatttct ag                                               22

<210>  11272
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11272
tcaaggaaga tggcatttct ag                                               22

<210>  11273
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11273
tcaaggaaga tggcatttct ag                                               22

<210>  11274
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11274
tcaaggaaga tggcatttct ag                                               22

<210>  11275
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11275
tcaaggaaga tggcatttct ag                                               22

<210>  11276
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11276
ggtaagttct gtccaagc                                                    18

<210>  11277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11277
ggtaagttct gtccaagc                                                    18

<210>  11278
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11278
ggtaagttct gtccaagc                                                    18

<210>  11279
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11279
ggtaagttct gtccaagc                                                    18

<210>  11280
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11280
ggtaagttct gtccaagc                                                    18

<210>  11281
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11281
ggtaagttct gtccaagc                                                    18

<210>  11282
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11282
ggtaagttct gtccaagc                                                    18

<210>  11283
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11283
gtaagttctg tccaagcc                                                    18

<210>  11284
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11284
gtaagttctg tccaagcc                                                    18

<210>  11285
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11285
gtaagttctg tccaagcc                                                    18

<210>  11286
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11286
gtaagttctg tccaagcc                                                    18

<210>  11287
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11287
gtaagttctg tccaagcc                                                    18

<210>  11288
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11288
gtaagttctg tccaagcc                                                    18

<210>  11289
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11289
gtaagttctg tccaagcc                                                    18

<210>  11290
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11290
agtcggtaag ttctgtcc                                                    18

<210>  11291
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  11291
agtcggtaag ttctgtcc                                                    18

<210>  11292
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11292
agtcggtaag ttctgtcc                                                    18

<210>  11293
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11293
agtcggtaag ttctgtcc                                                    18

<210>  11294
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11294
agtcggtaag ttctgtcc                                                    18

<210>  11295
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11295
agtcggtaag ttctgtcc                                                    18

<210>  11296
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11296
agtcggtaag ttctgtcc                                                    18

<210>  11297
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11297
agtcggtaag ttctgtcc                                                    18

<210>  11298
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  11298
ctgtccaagc ccggttga                                                    18

<210>  11299
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11299
ctgtccaagc ccggttga                                                    18

<210>  11300
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11300
ctgtccaagc ccggttga                                                    18

<210>  11301
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11301
ctgtccaagc ccggttga                                                    18

<210>  11302
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11302
ctgtccaagc ccggttga                                                    18

<210>  11303
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11303
ctgtccaagc ccggttga                                                    18

<210>  11304
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11304
ctgtccaagc ccggttga                                                    18

<210>  11305
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11305
ctgtccaagc ccggttga                                                    18

<210>  11306
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11306
ctgtccaagc ccggttga                                                    18

<210>  11307
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11307
ctgtccaagc ccggttga                                                    18

<210>  11308
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11308
ggtaagttct gtccaagc                                                    18

<210>  11309
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11309
ggtaagttct gtccaagc                                                    18

<210>  11310
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11310
ggtaagttct gtccaagc                                                    18

<210>  11311
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11311
ggtaagttct gtccaagc                                                    18

<210>  11312
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11312
ggtaagttct gtccaagc                                                    18

<210>  11313
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11313
ggtaagttct gtccaagc                                                    18

<210>  11314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11314
ggtaagttct gtccaagc                                                    18

<210>  11315
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11315
ggtaagttct gtccaagc                                                    18

<210>  11316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11316
ggtaagttct gtccaagc                                                    18

<210>  11317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11317
ggtaagttct gtccaagc                                                    18

<210>  11318
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11318
ggtaagttct gtccaagc                                                    18

<210>  11319
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11319
ggtaagttct gtccaagc                                                    18

<210>  11320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11320
ggtaagttct gtccaagc                                                    18

<210>  11321
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11321
ggtaagttct gtccaagc                                                    18

<210>  11322
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11322
ggtaagttct gtccaagc                                                    18

<210>  11323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11323
ggtaagttct gtccaagc                                                    18

<210>  11324
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11324
ggtaagttct gtccaagc                                                    18

<210>  11325
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11325
ggtaagttct gtccaagc                                                    18

<210>  11326
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11326
ggtaagttct gtccaagc                                                    18

<210>  11327
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11327
ggtaagttct gtccaagc                                                    18

<210>  11328
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11328
ggtaagttct gtccaagc                                                    18

<210>  11329
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11329
gtaagttctg tccaagcc                                                    18

<210>  11330
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11330
gtaagttctg tccaagcc                                                    18

<210>  11331
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11331
gtaagttctg tccaagcc                                                    18

<210>  11332
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11332
gtaagttctg tccaagcc                                                    18

<210>  11333
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11333
gtaagttctg tccaagcc                                                    18

<210>  11334
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11334
gtaagttctg tccaagcc                                                    18

<210>  11335
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11335
gtaagttctg tccaagcc                                                    18

<210>  11336
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11336
gtaagttctg tccaagcc                                                    18

<210>  11337
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11337
gtaagttctg tccaagcc                                                    18

<210>  11338
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11338
gtaagttctg tccaagcc                                                    18

<210>  11339
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11339
gtaagttctg tccaagcc                                                    18

<210>  11340
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11340
gtaagttctg tccaagcc                                                    18

<210>  11341
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11341
gtaagttctg tccaagcc                                                    18

<210>  11342
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11342
gtaagttctg tccaagcc                                                    18

<210>  11343
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11343
gtaagttctg tccaagcc                                                    18

<210>  11344
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11344
gtaagttctg tccaagcc                                                    18

<210>  11345
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11345
gtaagttctg tccaagcc                                                    18

<210>  11346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11346
gtaagttctg tccaagcc                                                    18

<210>  11347
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11347
gtaagttctg tccaagcc                                                    18

<210>  11348
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11348
gtaagttctg tccaagcc                                                    18

<210>  11349
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11349
gtaagttctg tccaagcc                                                    18

<210>  11350
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11350
agtcggtaag ttctgtcc                                                    18

<210>  11351
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11351
agtcggtaag ttctgtcc                                                    18

<210>  11352
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11352
agtcggtaag ttctgtcc                                                    18

<210>  11353
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11353
agtcggtaag ttctgtcc                                                    18

<210>  11354
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11354
agtcggtaag ttctgtcc                                                    18

<210>  11355
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11355
agtcggtaag ttctgtcc                                                    18

<210>  11356
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11356
agtcggtaag ttctgtcc                                                    18

<210>  11357
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11357
agtcggtaag ttctgtcc                                                    18

<210>  11358
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11358
agtcggtaag ttctgtcc                                                    18

<210>  11359
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11359
agtcggtaag ttctgtcc                                                    18

<210>  11360
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11360
agtcggtaag ttctgtcc                                                    18

<210>  11361
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11361
agtcggtaag ttctgtcc                                                    18

<210>  11362
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11362
agtcggtaag ttctgtcc                                                    18

<210>  11363
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11363
agtcggtaag ttctgtcc                                                    18

<210>  11364
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11364
agtcggtaag ttctgtcc                                                    18

<210>  11365
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11365
agtcggtaag ttctgtcc                                                    18

<210>  11366
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11366
agtcggtaag ttctgtcc                                                    18

<210>  11367
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11367
agtcggtaag ttctgtcc                                                    18

<210>  11368
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11368
agtcggtaag ttctgtcc                                                    18

<210>  11369
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11369
agtcggtaag ttctgtcc                                                    18

<210>  11370
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11370
agtcggtaag ttctgtcc                                                    18

<210>  11371
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11371
agtcggtaag ttctgtcc                                                    18

<210>  11372
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11372
agtcggtaag ttctgtcc                                                    18

<210>  11373
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11373
agtcggtaag ttctgtcc                                                    18

<210>  11374
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11374
agtcggtaag ttctgtcc                                                    18

<210>  11375
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11375
agtcggtaag ttctgtcc                                                    18

<210>  11376
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11376
agtcggtaag ttctgtcc                                                    18

<210>  11377
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11377
agtcggtaag ttctgtcc                                                    18

<210>  11378
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11378
ctgtccaagc ccggttga                                                    18

<210>  11379
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11379
ctgtccaagc ccggttga                                                    18

<210>  11380
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11380
ctgtccaagc ccggttga                                                    18

<210>  11381
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11381
ctgtccaagc ccggttga                                                    18

<210>  11382
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11382
ctgtccaagc ccggttga                                                    18

<210>  11383
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11383
ctgtccaagc ccggttga                                                    18

<210>  11384
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11384
ctgtccaagc ccggttga                                                    18

<210>  11385
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11385
ctgtccaagc ccggttga                                                    18

<210>  11386
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11386
ctgtccaagc ccggttga                                                    18

<210>  11387
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11387
ctgtccaagc ccggttga                                                    18

<210>  11388
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11388
ctgtccaagc ccggttga                                                    18

<210>  11389
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11389
ctgtccaagc ccggttga                                                    18

<210>  11390
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11390
ctgtccaagc ccggttga                                                    18

<210>  11391
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11391
ctgtccaagc ccggttga                                                    18

<210>  11392
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11392
ctgtccaagc ccggttga                                                    18

<210>  11393
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11393
ctgtccaagc ccggttga                                                    18

<210>  11394
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11394
ctgtccaagc ccggttga                                                    18

<210>  11395
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11395
ctgtccaagc ccggttga                                                    18

<210>  11396
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11396
ctgtccaagc ccggttga                                                    18

<210>  11397
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11397
ctgtccaagc ccggttga                                                    18

<210>  11398
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11398
ctgtccaagc ccggttga                                                    18

<210>  11399
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11399
ctgtccaagc ccggttga                                                    18

<210>  11400
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11400
ctgtccaagc ccggttga                                                    18

<210>  11401
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11401
ctgtccaagc ccggttga                                                    18

<210>  11402
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11402
ctgtccaagc ccggttga                                                    18

<210>  11403
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11403
ctgtccaagc ccggttga                                                    18

<210>  11404
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11404
ctgtccaagc ccggttga                                                    18

<210>  11405
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11405
ctgtccaagc ccggttga                                                    18

<210>  11406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11406
ctgtccaagc ccggttga                                                    18

<210>  11407
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11407
ctgtccaagc ccggttga                                                    18

<210>  11408
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11408
ctgtccaagc ccggttga                                                    18

<210>  11409
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11409
ctgtccaagc ccggttga                                                    18

<210>  11410
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11410
ctgtccaagc ccggttga                                                    18

<210>  11411
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11411
ctgtccaagc ccggttga                                                    18

<210>  11412
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11412
ctgtccaagc ccggttga                                                    18

<210>  11413
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11413
ctgtccaagc ccggttga                                                    18

<210>  11414
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11414
ctgtccaagc ccggttga                                                    18

<210>  11415
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11415
ctgtccaagc ccggttga                                                    18

<210>  11416
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11416
ctgtccaagc ccggttga                                                    18

<210>  11417
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11417
ctgtccaagc ccggttga                                                    18

<210>  11418
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11418
ctgtccaagc ccggttga                                                    18

<210>  11419
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11419
ctgtccaagc ccggttga                                                    18

<210>  11420
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11420
ctgtccaagc ccggttga                                                    18

<210>  11421
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11421
ctgtccaagc ccggttga                                                    18

<210>  11422
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11422
ctgtccaagc ccggttga                                                    18

<210>  11423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  11423
tcaaggaaga tggcatttct                                                  20

<210>  11424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11424
tcaaggaaga tggcatttct                                                  20

<210>  11425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11425
tcaaggaaga tggcatttct                                                  20

<210>  11426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11426
tcaaggaaga tggcatttct                                                  20

<210>  11427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11427
tcaaggaaga tggcatttct                                                  20

<210>  11428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11428
tcaaggaaga tggcatttct                                                  20

<210>  11429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11429
tcaaggaaga tggcatttct                                                  20

<210>  11430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11430
tcaaggaaga tggcatttct                                                  20

<210>  11431
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  11431
tcaaggaaga tggcatttct ag                                               22

<210>  11432
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11432
tcaaggaaga tggcatttct ag                                               22

<210>  11433
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11433
tcaaggaaga tggcatttct ag                                               22

<210>  11434
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11434
tcaaggaaga tggcatttct ag                                               22

<210>  11435
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11435
tcaaggaaga tggcatttct ag                                               22

<210>  11436
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11436
tcaaggaaga tggcatttct ag                                               22

<210>  11437
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11437
tcaaggaaga tggcatttct ag                                               22

<210>  11438
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11438
tcaaggaaga tggcatttct ag                                               22

<210>  11439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11439
tcaaggaaga tggcatttct                                                  20

<210>  11440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11440
tcaaggaaga tggcatttct                                                  20

<210>  11441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11441
tcaaggaaga tggcatttct                                                  20

<210>  11442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11442
tcaaggaaga tggcatttct                                                  20

<210>  11443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11443
tcaaggaaga tggcatttct                                                  20

<210>  11444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11444
tcaaggaaga tggcatttct                                                  20

<210>  11445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11445
tcaaggaaga tggcatttct                                                  20

<210>  11446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11446
tcaaggaaga tggcatttct                                                  20

<210>  11447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11447
tcaaggaaga tggcatttct                                                  20

<210>  11448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11448
tcaaggaaga tggcatttct                                                  20

<210>  11449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11449
tcaaggaaga tggcatttct                                                  20

<210>  11450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11450
tcaaggaaga tggcatttct                                                  20

<210>  11451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11451
tcaaggaaga tggcatttct                                                  20

<210>  11452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11452
tcaaggaaga tggcatttct                                                  20

<210>  11453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11453
tcaaggaaga tggcatttct                                                  20

<210>  11454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11454
tcaaggaaga tggcatttct                                                  20

<210>  11455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11455
tcaaggaaga tggcatttct                                                  20

<210>  11456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11456
tcaaggaaga tggcatttct                                                  20

<210>  11457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11457
tcaaggaaga tggcatttct                                                  20

<210>  11458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11458
tcaaggaaga tggcatttct                                                  20

<210>  11459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11459
tcaaggaaga tggcatttct                                                  20

<210>  11460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11460
tcaaggaaga tggcatttct                                                  20

<210>  11461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11461
tcaaggaaga tggcatttct                                                  20

<210>  11462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11462
tcaaggaaga tggcatttct                                                  20

<210>  11463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11463
tcaaggaaga tggcatttct                                                  20

<210>  11464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11464
tcaaggaaga tggcatttct                                                  20

<210>  11465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11465
tcaaggaaga tggcatttct                                                  20

<210>  11466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11466
tcaaggaaga tggcatttct                                                  20

<210>  11467
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11467
tcaaggaaga tggcatttct ag                                               22

<210>  11468
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11468
tcaaggaaga tggcatttct ag                                               22

<210>  11469
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11469
tcaaggaaga tggcatttct ag                                               22

<210>  11470
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11470
tcaaggaaga tggcatttct ag                                               22

<210>  11471
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11471
tcaaggaaga tggcatttct ag                                               22

<210>  11472
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11472
tcaaggaaga tggcatttct ag                                               22

<210>  11473
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11473
tcaaggaaga tggcatttct ag                                               22

<210>  11474
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11474
tcaaggaaga tggcatttct ag                                               22

<210>  11475
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11475
tcaaggaaga tggcatttct ag                                               22

<210>  11476
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11476
tcaaggaaga tggcatttct ag                                               22

<210>  11477
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11477
tcaaggaaga tggcatttct ag                                               22

<210>  11478
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11478
tcaaggaaga tggcatttct ag                                               22

<210>  11479
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11479
tcaaggaaga tggcatttct ag                                               22

<210>  11480
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11480
tcaaggaaga tggcatttct ag                                               22

<210>  11481
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11481
tcaaggaaga tggcatttct ag                                               22

<210>  11482
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11482
tcaaggaaga tggcatttct ag                                               22

<210>  11483
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11483
tcaaggaaga tggcatttct ag                                               22

<210>  11484
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11484
tcaaggaaga tggcatttct ag                                               22

<210>  11485
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11485
tcaaggaaga tggcatttct ag                                               22

<210>  11486
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11486
tcaaggaaga tggcatttct ag                                               22

<210>  11487
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11487
tcaaggaaga tggcatttct ag                                               22

<210>  11488
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11488
tcaaggaaga tggcatttct ag                                               22

<210>  11489
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11489
tcaaggaaga tggcatttct ag                                               22

<210>  11490
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11490
tcaaggaaga tggcatttct ag                                               22

<210>  11491
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11491
tcaaggaaga tggcatttct ag                                               22

<210>  11492
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11492
tcaaggaaga tggcatttct ag                                               22

<210>  11493
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11493
tcaaggaaga tggcatttct ag                                               22

<210>  11494
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11494
tcaaggaaga tggcatttct ag                                               22

<210>  11495
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11495
gguaaguucu guccaagc                                                    18

<210>  11496
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11496
gguaaguucu guccaagc                                                    18

<210>  11497
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11497
gguaaguucu guccaagc                                                    18

<210>  11498
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11498
gguaaguucu guccaagc                                                    18

<210>  11499
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11499
gguaaguucu guccaagc                                                    18

<210>  11500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11500
gguaaguucu guccaagc                                                    18

<210>  11501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11501
guaaguucug uccaagcc                                                    18

<210>  11502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11502
guaaguucug uccaagcc                                                    18

<210>  11503
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11503
guaaguucug uccaagcc                                                    18

<210>  11504
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11504
guaaguucug uccaagcc                                                    18

<210>  11505
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11505
guaaguucug uccaagcc                                                    18

<210>  11506
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11506
guaaguucug uccaagcc                                                    18

<210>  11507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11507
guaaguucug uccaagcc                                                    18

<210>  11508
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  11508
agucgguaag uucugucc                                                    18

<210>  11509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11509
agucgguaag uucugucc                                                    18

<210>  11510
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11510
agucgguaag uucugucc                                                    18

<210>  11511
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11511
agucgguaag uucugucc                                                    18

<210>  11512
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11512
agucgguaag uucugucc                                                    18

<210>  11513
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11513
agucgguaag uucugucc                                                    18

<210>  11514
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11514
agucgguaag uucugucc                                                    18

<210>  11515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  11515
cuguccaagc ccgguuga                                                    18

<210>  11516
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11516
cuguccaagc ccgguuga                                                    18

<210>  11517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11517
cuguccaagc ccgguuga                                                    18

<210>  11518
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11518
cuguccaagc ccgguuga                                                    18

<210>  11519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11519
cuguccaagc ccgguuga                                                    18

<210>  11520
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11520
cuguccaagc ccgguuga                                                    18

<210>  11521
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11521
cuguccaagc ccgguuga                                                    18

<210>  11522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11522
cuguccaagc ccgguuga                                                    18

<210>  11523
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11523
cuguccaagc ccgguuga                                                    18

<210>  11524
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11524
cuguccaagc ccgguuga                                                    18

<210>  11525
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11525
gguaaguucu guccaagc                                                    18

<210>  11526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11526
gguaaguucu guccaagc                                                    18

<210>  11527
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11527
gguaaguucu guccaagc                                                    18

<210>  11528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11528
gguaaguucu guccaagc                                                    18

<210>  11529
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11529
gguaaguucu guccaagc                                                    18

<210>  11530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11530
gguaaguucu guccaagc                                                    18

<210>  11531
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11531
gguaaguucu guccaagc                                                    18

<210>  11532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11532
gguaaguucu guccaagc                                                    18

<210>  11533
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11533
gguaaguucu guccaagc                                                    18

<210>  11534
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11534
gguaaguucu guccaagc                                                    18

<210>  11535
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11535
gguaaguucu guccaagc                                                    18

<210>  11536
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11536
gguaaguucu guccaagc                                                    18

<210>  11537
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11537
gguaaguucu guccaagc                                                    18

<210>  11538
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11538
gguaaguucu guccaagc                                                    18

<210>  11539
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11539
gguaaguucu guccaagc                                                    18

<210>  11540
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11540
guaaguucug uccaagcc                                                    18

<210>  11541
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11541
guaaguucug uccaagcc                                                    18

<210>  11542
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11542
guaaguucug uccaagcc                                                    18

<210>  11543
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11543
guaaguucug uccaagcc                                                    18

<210>  11544
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11544
guaaguucug uccaagcc                                                    18

<210>  11545
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11545
guaaguucug uccaagcc                                                    18

<210>  11546
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11546
guaaguucug uccaagcc                                                    18

<210>  11547
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11547
guaaguucug uccaagcc                                                    18

<210>  11548
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11548
guaaguucug uccaagcc                                                    18

<210>  11549
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11549
guaaguucug uccaagcc                                                    18

<210>  11550
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11550
guaaguucug uccaagcc                                                    18

<210>  11551
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11551
guaaguucug uccaagcc                                                    18

<210>  11552
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11552
guaaguucug uccaagcc                                                    18

<210>  11553
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11553
guaaguucug uccaagcc                                                    18

<210>  11554
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11554
guaaguucug uccaagcc                                                    18

<210>  11555
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11555
guaaguucug uccaagcc                                                    18

<210>  11556
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11556
guaaguucug uccaagcc                                                    18

<210>  11557
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11557
guaaguucug uccaagcc                                                    18

<210>  11558
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11558
guaaguucug uccaagcc                                                    18

<210>  11559
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11559
guaaguucug uccaagcc                                                    18

<210>  11560
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11560
guaaguucug uccaagcc                                                    18

<210>  11561
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11561
agucgguaag uucugucc                                                    18

<210>  11562
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11562
agucgguaag uucugucc                                                    18

<210>  11563
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11563
agucgguaag uucugucc                                                    18

<210>  11564
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11564
agucgguaag uucugucc                                                    18

<210>  11565
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11565
agucgguaag uucugucc                                                    18

<210>  11566
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11566
agucgguaag uucugucc                                                    18

<210>  11567
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11567
agucgguaag uucugucc                                                    18

<210>  11568
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11568
agucgguaag uucugucc                                                    18

<210>  11569
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11569
agucgguaag uucugucc                                                    18

<210>  11570
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11570
agucgguaag uucugucc                                                    18

<210>  11571
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11571
agucgguaag uucugucc                                                    18

<210>  11572
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11572
agucgguaag uucugucc                                                    18

<210>  11573
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11573
agucgguaag uucugucc                                                    18

<210>  11574
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11574
agucgguaag uucugucc                                                    18

<210>  11575
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11575
agucgguaag uucugucc                                                    18

<210>  11576
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11576
agucgguaag uucugucc                                                    18

<210>  11577
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11577
agucgguaag uucugucc                                                    18

<210>  11578
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11578
agucgguaag uucugucc                                                    18

<210>  11579
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11579
agucgguaag uucugucc                                                    18

<210>  11580
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11580
agucgguaag uucugucc                                                    18

<210>  11581
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11581
agucgguaag uucugucc                                                    18

<210>  11582
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11582
cuguccaagc ccgguuga                                                    18

<210>  11583
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11583
cuguccaagc ccgguuga                                                    18

<210>  11584
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11584
cuguccaagc ccgguuga                                                    18

<210>  11585
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11585
cuguccaagc ccgguuga                                                    18

<210>  11586
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11586
cuguccaagc ccgguuga                                                    18

<210>  11587
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11587
cuguccaagc ccgguuga                                                    18

<210>  11588
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11588
cuguccaagc ccgguuga                                                    18

<210>  11589
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11589
cuguccaagc ccgguuga                                                    18

<210>  11590
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11590
cuguccaagc ccgguuga                                                    18

<210>  11591
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11591
cuguccaagc ccgguuga                                                    18

<210>  11592
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11592
cuguccaagc ccgguuga                                                    18

<210>  11593
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11593
cuguccaagc ccgguuga                                                    18

<210>  11594
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11594
cuguccaagc ccgguuga                                                    18

<210>  11595
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11595
cuguccaagc ccgguuga                                                    18

<210>  11596
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11596
cuguccaagc ccgguuga                                                    18

<210>  11597
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11597
cuguccaagc ccgguuga                                                    18

<210>  11598
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11598
cuguccaagc ccgguuga                                                    18

<210>  11599
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11599
cuguccaagc ccgguuga                                                    18

<210>  11600
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11600
cuguccaagc ccgguuga                                                    18

<210>  11601
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11601
cuguccaagc ccgguuga                                                    18

<210>  11602
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11602
cuguccaagc ccgguuga                                                    18

<210>  11603
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11603
cuguccaagc ccgguuga                                                    18

<210>  11604
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11604
cuguccaagc ccgguuga                                                    18

<210>  11605
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11605
cuguccaagc ccgguuga                                                    18

<210>  11606
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11606
cuguccaagc ccgguuga                                                    18

<210>  11607
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11607
cuguccaagc ccgguuga                                                    18

<210>  11608
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11608
cuguccaagc ccgguuga                                                    18

<210>  11609
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11609
cuguccaagc ccgguuga                                                    18

<210>  11610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11610
cuguccaagc ccgguuga                                                    18

<210>  11611
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11611
cuguccaagc ccgguuga                                                    18

<210>  11612
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11612
cuguccaagc ccgguuga                                                    18

<210>  11613
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11613
cuguccaagc ccgguuga                                                    18

<210>  11614
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11614
cuguccaagc ccgguuga                                                    18

<210>  11615
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11615
cuguccaagc ccgguuga                                                    18

<210>  11616
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11616
cuguccaagc ccgguuga                                                    18

<210>  11617
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11617
cuguccaagc ccgguuga                                                    18

<210>  11618
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11618
cuguccaagc ccgguuga                                                    18

<210>  11619
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11619
cuguccaagc ccgguuga                                                    18

<210>  11620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11620
cuguccaagc ccgguuga                                                    18

<210>  11621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11621
cuguccaagc ccgguuga                                                    18

<210>  11622
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11622
cuguccaagc ccgguuga                                                    18

<210>  11623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11623
cuguccaagc ccgguuga                                                    18

<210>  11624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11624
cuguccaagc ccgguuga                                                    18

<210>  11625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11625
cuguccaagc ccgguuga                                                    18

<210>  11626
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11626
cuguccaagc ccgguuga                                                    18

<210>  11627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11627
tcaaggaaga uggcauuucu                                                  20

<210>  11628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11628
tcaaggaaga uggcauuucu                                                  20

<210>  11629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11629
tcaaggaaga uggcauuucu                                                  20

<210>  11630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11630
tcaaggaaga uggcauuucu                                                  20

<210>  11631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11631
tcaaggaaga uggcauuucu                                                  20

<210>  11632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11632
tcaaggaaga uggcauuucu                                                  20

<210>  11633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11633
tcaaggaaga uggcauuucu                                                  20

<210>  11634
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11634
tcaaggaaga uggcauuucu ag                                               22

<210>  11635
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11635
tcaaggaaga uggcauuucu ag                                               22

<210>  11636
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11636
tcaaggaaga uggcauuucu ag                                               22

<210>  11637
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11637
tcaaggaaga uggcauuucu ag                                               22

<210>  11638
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11638
tcaaggaaga uggcauuucu ag                                               22

<210>  11639
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11639
tcaaggaaga uggcauuucu ag                                               22

<210>  11640
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11640
tcaaggaaga uggcauuucu ag                                               22

<210>  11641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11641
tcaaggaaga uggcauuucu                                                  20

<210>  11642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11642
tcaaggaaga uggcauuucu                                                  20

<210>  11643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11643
tcaaggaaga uggcauuucu                                                  20

<210>  11644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11644
tcaaggaaga uggcauuucu                                                  20

<210>  11645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11645
tcaaggaaga uggcauuucu                                                  20

<210>  11646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11646
tcaaggaaga uggcauuucu                                                  20

<210>  11647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11647
tcaaggaaga uggcauuucu                                                  20

<210>  11648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11648
tcaaggaaga uggcauuucu                                                  20

<210>  11649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11649
tcaaggaaga uggcauuucu                                                  20

<210>  11650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11650
tcaaggaaga uggcauuucu                                                  20

<210>  11651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11651
tcaaggaaga uggcauuucu                                                  20

<210>  11652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11652
tcaaggaaga uggcauuucu                                                  20

<210>  11653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11653
tcaaggaaga uggcauuucu                                                  20

<210>  11654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11654
tcaaggaaga uggcauuucu                                                  20

<210>  11655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11655
tcaaggaaga uggcauuucu                                                  20

<210>  11656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11656
tcaaggaaga uggcauuucu                                                  20

<210>  11657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11657
tcaaggaaga uggcauuucu                                                  20

<210>  11658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11658
tcaaggaaga uggcauuucu                                                  20

<210>  11659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11659
tcaaggaaga uggcauuucu                                                  20

<210>  11660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11660
tcaaggaaga uggcauuucu                                                  20

<210>  11661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11661
tcaaggaaga uggcauuucu                                                  20

<210>  11662
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11662
tcaaggaaga uggcauuucu ag                                               22

<210>  11663
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11663
tcaaggaaga uggcauuucu ag                                               22

<210>  11664
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11664
tcaaggaaga uggcauuucu ag                                               22

<210>  11665
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11665
tcaaggaaga uggcauuucu ag                                               22

<210>  11666
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11666
tcaaggaaga uggcauuucu ag                                               22

<210>  11667
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11667
tcaaggaaga uggcauuucu ag                                               22

<210>  11668
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11668
tcaaggaaga uggcauuucu ag                                               22

<210>  11669
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11669
tcaaggaaga uggcauuucu ag                                               22

<210>  11670
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11670
tcaaggaaga uggcauuucu ag                                               22

<210>  11671
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11671
tcaaggaaga uggcauuucu ag                                               22

<210>  11672
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11672
tcaaggaaga uggcauuucu ag                                               22

<210>  11673
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11673
tcaaggaaga uggcauuucu ag                                               22

<210>  11674
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11674
tcaaggaaga uggcauuucu ag                                               22

<210>  11675
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11675
tcaaggaaga uggcauuucu ag                                               22

<210>  11676
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11676
tcaaggaaga uggcauuucu ag                                               22

<210>  11677
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11677
tcaaggaaga uggcauuucu ag                                               22

<210>  11678
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11678
tcaaggaaga uggcauuucu ag                                               22

<210>  11679
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11679
tcaaggaaga uggcauuucu ag                                               22

<210>  11680
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11680
tcaaggaaga uggcauuucu ag                                               22

<210>  11681
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11681
tcaaggaaga uggcauuucu ag                                               22

<210>  11682
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  11682
tcaaggaaga uggcauuucu ag                                               22

<210>  11683
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11683
gguaaguucu guccaagc                                                    18

<210>  11684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11684
gguaaguucu guccaagc                                                    18

<210>  11685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11685
gguaaguucu guccaagc                                                    18

<210>  11686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11686
gguaaguucu guccaagc                                                    18

<210>  11687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11687
gguaaguucu guccaagc                                                    18

<210>  11688
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11688
gguaaguucu guccaagc                                                    18

<210>  11689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11689
guaaguucug uccaagcc                                                    18

<210>  11690
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11690
guaaguucug uccaagcc                                                    18

<210>  11691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11691
guaaguucug uccaagcc                                                    18

<210>  11692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11692
guaaguucug uccaagcc                                                    18

<210>  11693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11693
guaaguucug uccaagcc                                                    18

<210>  11694
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11694
guaaguucug uccaagcc                                                    18

<210>  11695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11695
guaaguucug uccaagcc                                                    18

<210>  11696
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11696
agucgguaag uucugucc                                                    18

<210>  11697
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11697
agucgguaag uucugucc                                                    18

<210>  11698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11698
agucgguaag uucugucc                                                    18

<210>  11699
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11699
agucgguaag uucugucc                                                    18

<210>  11700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11700
agucgguaag uucugucc                                                    18

<210>  11701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11701
agucgguaag uucugucc                                                    18

<210>  11702
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11702
agucgguaag uucugucc                                                    18

<210>  11703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  11703
cuguccaagc ccgguuga                                                    18

<210>  11704
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11704
cuguccaagc ccgguuga                                                    18

<210>  11705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11705
cuguccaagc ccgguuga                                                    18

<210>  11706
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11706
cuguccaagc ccgguuga                                                    18

<210>  11707
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11707
cuguccaagc ccgguuga                                                    18

<210>  11708
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11708
cuguccaagc ccgguuga                                                    18

<210>  11709
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11709
cuguccaagc ccgguuga                                                    18

<210>  11710
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11710
cuguccaagc ccgguuga                                                    18

<210>  11711
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11711
cuguccaagc ccgguuga                                                    18

<210>  11712
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11712
cuguccaagc ccgguuga                                                    18

<210>  11713
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11713
gguaaguucu guccaagc                                                    18

<210>  11714
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11714
gguaaguucu guccaagc                                                    18

<210>  11715
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11715
gguaaguucu guccaagc                                                    18

<210>  11716
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11716
gguaaguucu guccaagc                                                    18

<210>  11717
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11717
gguaaguucu guccaagc                                                    18

<210>  11718
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11718
gguaaguucu guccaagc                                                    18

<210>  11719
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11719
gguaaguucu guccaagc                                                    18

<210>  11720
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11720
gguaaguucu guccaagc                                                    18

<210>  11721
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11721
gguaaguucu guccaagc                                                    18

<210>  11722
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11722
gguaaguucu guccaagc                                                    18

<210>  11723
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11723
gguaaguucu guccaagc                                                    18

<210>  11724
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11724
gguaaguucu guccaagc                                                    18

<210>  11725
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11725
gguaaguucu guccaagc                                                    18

<210>  11726
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11726
gguaaguucu guccaagc                                                    18

<210>  11727
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  11727
gguaaguucu guccaagc                                                    18

<210>  11728
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11728
guaaguucug uccaagcc                                                    18

<210>  11729
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11729
guaaguucug uccaagcc                                                    18

<210>  11730
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11730
guaaguucug uccaagcc                                                    18

<210>  11731
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11731
guaaguucug uccaagcc                                                    18

<210>  11732
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11732
guaaguucug uccaagcc                                                    18

<210>  11733
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11733
guaaguucug uccaagcc                                                    18

<210>  11734
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11734
guaaguucug uccaagcc                                                    18

<210>  11735
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11735
guaaguucug uccaagcc                                                    18

<210>  11736
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11736
guaaguucug uccaagcc                                                    18

<210>  11737
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11737
guaaguucug uccaagcc                                                    18

<210>  11738
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11738
guaaguucug uccaagcc                                                    18

<210>  11739
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11739
guaaguucug uccaagcc                                                    18

<210>  11740
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11740
guaaguucug uccaagcc                                                    18

<210>  11741
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11741
guaaguucug uccaagcc                                                    18

<210>  11742
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11742
guaaguucug uccaagcc                                                    18

<210>  11743
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11743
guaaguucug uccaagcc                                                    18

<210>  11744
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11744
guaaguucug uccaagcc                                                    18

<210>  11745
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11745
guaaguucug uccaagcc                                                    18

<210>  11746
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11746
guaaguucug uccaagcc                                                    18

<210>  11747
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11747
guaaguucug uccaagcc                                                    18

<210>  11748
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11748
guaaguucug uccaagcc                                                    18

<210>  11749
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11749
agucgguaag uucugucc                                                    18

<210>  11750
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11750
agucgguaag uucugucc                                                    18

<210>  11751
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11751
agucgguaag uucugucc                                                    18

<210>  11752
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11752
agucgguaag uucugucc                                                    18

<210>  11753
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11753
agucgguaag uucugucc                                                    18

<210>  11754
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11754
agucgguaag uucugucc                                                    18

<210>  11755
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11755
agucgguaag uucugucc                                                    18

<210>  11756
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11756
agucgguaag uucugucc                                                    18

<210>  11757
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11757
agucgguaag uucugucc                                                    18

<210>  11758
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11758
agucgguaag uucugucc                                                    18

<210>  11759
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11759
agucgguaag uucugucc                                                    18

<210>  11760
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11760
agucgguaag uucugucc                                                    18

<210>  11761
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11761
agucgguaag uucugucc                                                    18

<210>  11762
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11762
agucgguaag uucugucc                                                    18

<210>  11763
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11763
agucgguaag uucugucc                                                    18

<210>  11764
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11764
agucgguaag uucugucc                                                    18

<210>  11765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11765
agucgguaag uucugucc                                                    18

<210>  11766
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11766
agucgguaag uucugucc                                                    18

<210>  11767
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11767
agucgguaag uucugucc                                                    18

<210>  11768
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11768
agucgguaag uucugucc                                                    18

<210>  11769
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  11769
agucgguaag uucugucc                                                    18

<210>  11770
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11770
cuguccaagc ccgguuga                                                    18

<210>  11771
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11771
cuguccaagc ccgguuga                                                    18

<210>  11772
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11772
cuguccaagc ccgguuga                                                    18

<210>  11773
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11773
cuguccaagc ccgguuga                                                    18

<210>  11774
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11774
cuguccaagc ccgguuga                                                    18

<210>  11775
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11775
cuguccaagc ccgguuga                                                    18

<210>  11776
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11776
cuguccaagc ccgguuga                                                    18

<210>  11777
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11777
cuguccaagc ccgguuga                                                    18

<210>  11778
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11778
cuguccaagc ccgguuga                                                    18

<210>  11779
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11779
cuguccaagc ccgguuga                                                    18

<210>  11780
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11780
cuguccaagc ccgguuga                                                    18

<210>  11781
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11781
cuguccaagc ccgguuga                                                    18

<210>  11782
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11782
cuguccaagc ccgguuga                                                    18

<210>  11783
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11783
cuguccaagc ccgguuga                                                    18

<210>  11784
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11784
cuguccaagc ccgguuga                                                    18

<210>  11785
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11785
cuguccaagc ccgguuga                                                    18

<210>  11786
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11786
cuguccaagc ccgguuga                                                    18

<210>  11787
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11787
cuguccaagc ccgguuga                                                    18

<210>  11788
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11788
cuguccaagc ccgguuga                                                    18

<210>  11789
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11789
cuguccaagc ccgguuga                                                    18

<210>  11790
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11790
cuguccaagc ccgguuga                                                    18

<210>  11791
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11791
cuguccaagc ccgguuga                                                    18

<210>  11792
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11792
cuguccaagc ccgguuga                                                    18

<210>  11793
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11793
cuguccaagc ccgguuga                                                    18

<210>  11794
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11794
cuguccaagc ccgguuga                                                    18

<210>  11795
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11795
cuguccaagc ccgguuga                                                    18

<210>  11796
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11796
cuguccaagc ccgguuga                                                    18

<210>  11797
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11797
cuguccaagc ccgguuga                                                    18

<210>  11798
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11798
cuguccaagc ccgguuga                                                    18

<210>  11799
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11799
cuguccaagc ccgguuga                                                    18

<210>  11800
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11800
cuguccaagc ccgguuga                                                    18

<210>  11801
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11801
cuguccaagc ccgguuga                                                    18

<210>  11802
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11802
cuguccaagc ccgguuga                                                    18

<210>  11803
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11803
cuguccaagc ccgguuga                                                    18

<210>  11804
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11804
cuguccaagc ccgguuga                                                    18

<210>  11805
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11805
cuguccaagc ccgguuga                                                    18

<210>  11806
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11806
cuguccaagc ccgguuga                                                    18

<210>  11807
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11807
cuguccaagc ccgguuga                                                    18

<210>  11808
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11808
cuguccaagc ccgguuga                                                    18

<210>  11809
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11809
cuguccaagc ccgguuga                                                    18

<210>  11810
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11810
cuguccaagc ccgguuga                                                    18

<210>  11811
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11811
cuguccaagc ccgguuga                                                    18

<210>  11812
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11812
cuguccaagc ccgguuga                                                    18

<210>  11813
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11813
cuguccaagc ccgguuga                                                    18

<210>  11814
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11814
cuguccaagc ccgguuga                                                    18

<210>  11815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11815
tcaaggaaga uggcauuucu                                                  20

<210>  11816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11816
tcaaggaaga uggcauuucu                                                  20

<210>  11817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11817
tcaaggaaga uggcauuucu                                                  20

<210>  11818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11818
tcaaggaaga uggcauuucu                                                  20

<210>  11819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11819
tcaaggaaga uggcauuucu                                                  20

<210>  11820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11820
tcaaggaaga uggcauuucu                                                  20

<210>  11821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11821
tcaaggaaga uggcauuucu                                                  20

<210>  11822
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11822
tcaaggaaga uggcauuucu ag                                               22

<210>  11823
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11823
tcaaggaaga uggcauuucu ag                                               22

<210>  11824
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11824
tcaaggaaga uggcauuucu ag                                               22

<210>  11825
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11825
tcaaggaaga uggcauuucu ag                                               22

<210>  11826
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11826
tcaaggaaga uggcauuucu ag                                               22

<210>  11827
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11827
tcaaggaaga uggcauuucu ag                                               22

<210>  11828
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11828
tcaaggaaga uggcauuucu ag                                               22

<210>  11829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11829
tcaaggaaga uggcauuucu                                                  20

<210>  11830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11830
tcaaggaaga uggcauuucu                                                  20

<210>  11831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11831
tcaaggaaga uggcauuucu                                                  20

<210>  11832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11832
tcaaggaaga uggcauuucu                                                  20

<210>  11833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11833
tcaaggaaga uggcauuucu                                                  20

<210>  11834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11834
tcaaggaaga uggcauuucu                                                  20

<210>  11835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11835
tcaaggaaga uggcauuucu                                                  20

<210>  11836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11836
tcaaggaaga uggcauuucu                                                  20

<210>  11837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11837
tcaaggaaga uggcauuucu                                                  20

<210>  11838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11838
tcaaggaaga uggcauuucu                                                  20

<210>  11839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11839
tcaaggaaga uggcauuucu                                                  20

<210>  11840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11840
tcaaggaaga uggcauuucu                                                  20

<210>  11841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11841
tcaaggaaga uggcauuucu                                                  20

<210>  11842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11842
tcaaggaaga uggcauuucu                                                  20

<210>  11843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11843
tcaaggaaga uggcauuucu                                                  20

<210>  11844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11844
tcaaggaaga uggcauuucu                                                  20

<210>  11845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11845
tcaaggaaga uggcauuucu                                                  20

<210>  11846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11846
tcaaggaaga uggcauuucu                                                  20

<210>  11847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11847
tcaaggaaga uggcauuucu                                                  20

<210>  11848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11848
tcaaggaaga uggcauuucu                                                  20

<210>  11849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11849
tcaaggaaga uggcauuucu                                                  20

<210>  11850
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11850
tcaaggaaga uggcauuucu ag                                               22

<210>  11851
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11851
tcaaggaaga uggcauuucu ag                                               22

<210>  11852
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11852
tcaaggaaga uggcauuucu ag                                               22

<210>  11853
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11853
tcaaggaaga uggcauuucu ag                                               22

<210>  11854
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11854
tcaaggaaga uggcauuucu ag                                               22

<210>  11855
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11855
tcaaggaaga uggcauuucu ag                                               22

<210>  11856
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11856
tcaaggaaga uggcauuucu ag                                               22

<210>  11857
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11857
tcaaggaaga uggcauuucu ag                                               22

<210>  11858
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11858
tcaaggaaga uggcauuucu ag                                               22

<210>  11859
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11859
tcaaggaaga uggcauuucu ag                                               22

<210>  11860
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11860
tcaaggaaga uggcauuucu ag                                               22

<210>  11861
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11861
tcaaggaaga uggcauuucu ag                                               22

<210>  11862
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11862
tcaaggaaga uggcauuucu ag                                               22

<210>  11863
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11863
tcaaggaaga uggcauuucu ag                                               22

<210>  11864
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11864
tcaaggaaga uggcauuucu ag                                               22

<210>  11865
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11865
tcaaggaaga uggcauuucu ag                                               22

<210>  11866
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11866
tcaaggaaga uggcauuucu ag                                               22

<210>  11867
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11867
tcaaggaaga uggcauuucu ag                                               22

<210>  11868
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11868
tcaaggaaga uggcauuucu ag                                               22

<210>  11869
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11869
tcaaggaaga uggcauuucu ag                                               22

<210>  11870
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  11870
tcaaggaaga uggcauuucu ag                                               22

<210>  11871
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11871
ggtaagttct gtccaagc                                                    18

<210>  11872
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11872
ggtaagttct gtccaagc                                                    18

<210>  11873
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11873
ggtaagttct gtccaagc                                                    18

<210>  11874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11874
ggtaagttct gtccaagc                                                    18

<210>  11875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11875
ggtaagttct gtccaagc                                                    18

<210>  11876
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11876
ggtaagttct gtccaagc                                                    18

<210>  11877
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11877
gtaagttctg tccaagcc                                                    18

<210>  11878
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11878
gtaagttctg tccaagcc                                                    18

<210>  11879
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11879
gtaagttctg tccaagcc                                                    18

<210>  11880
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11880
gtaagttctg tccaagcc                                                    18

<210>  11881
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11881
gtaagttctg tccaagcc                                                    18

<210>  11882
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11882
gtaagttctg tccaagcc                                                    18

<210>  11883
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11883
gtaagttctg tccaagcc                                                    18

<210>  11884
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  11884
agtcggtaag ttctgtcc                                                    18

<210>  11885
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11885
agtcggtaag ttctgtcc                                                    18

<210>  11886
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11886
agtcggtaag ttctgtcc                                                    18

<210>  11887
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11887
agtcggtaag ttctgtcc                                                    18

<210>  11888
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11888
agtcggtaag ttctgtcc                                                    18

<210>  11889
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11889
agtcggtaag ttctgtcc                                                    18

<210>  11890
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11890
agtcggtaag ttctgtcc                                                    18

<210>  11891
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  11891
ctgtccaagc ccggttga                                                    18

<210>  11892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11892
ctgtccaagc ccggttga                                                    18

<210>  11893
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11893
ctgtccaagc ccggttga                                                    18

<210>  11894
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11894
ctgtccaagc ccggttga                                                    18

<210>  11895
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11895
ctgtccaagc ccggttga                                                    18

<210>  11896
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11896
ctgtccaagc ccggttga                                                    18

<210>  11897
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11897
ctgtccaagc ccggttga                                                    18

<210>  11898
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11898
ctgtccaagc ccggttga                                                    18

<210>  11899
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11899
ctgtccaagc ccggttga                                                    18

<210>  11900
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11900
ctgtccaagc ccggttga                                                    18

<210>  11901
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11901
ggtaagttct gtccaagc                                                    18

<210>  11902
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11902
ggtaagttct gtccaagc                                                    18

<210>  11903
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11903
ggtaagttct gtccaagc                                                    18

<210>  11904
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11904
ggtaagttct gtccaagc                                                    18

<210>  11905
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11905
ggtaagttct gtccaagc                                                    18

<210>  11906
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11906
ggtaagttct gtccaagc                                                    18

<210>  11907
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11907
ggtaagttct gtccaagc                                                    18

<210>  11908
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11908
ggtaagttct gtccaagc                                                    18

<210>  11909
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11909
ggtaagttct gtccaagc                                                    18

<210>  11910
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11910
ggtaagttct gtccaagc                                                    18

<210>  11911
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11911
ggtaagttct gtccaagc                                                    18

<210>  11912
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11912
ggtaagttct gtccaagc                                                    18

<210>  11913
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11913
ggtaagttct gtccaagc                                                    18

<210>  11914
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11914
ggtaagttct gtccaagc                                                    18

<210>  11915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11915
ggtaagttct gtccaagc                                                    18

<210>  11916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11916
gtaagttctg tccaagcc                                                    18

<210>  11917
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  11917
gtaagttctg tccaagcc                                                    18

<210>  11918
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11918
gtaagttctg tccaagcc                                                    18

<210>  11919
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11919
gtaagttctg tccaagcc                                                    18

<210>  11920
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11920
gtaagttctg tccaagcc                                                    18

<210>  11921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11921
gtaagttctg tccaagcc                                                    18

<210>  11922
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11922
gtaagttctg tccaagcc                                                    18

<210>  11923
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11923
gtaagttctg tccaagcc                                                    18

<210>  11924
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11924
gtaagttctg tccaagcc                                                    18

<210>  11925
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11925
gtaagttctg tccaagcc                                                    18

<210>  11926
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11926
gtaagttctg tccaagcc                                                    18

<210>  11927
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11927
gtaagttctg tccaagcc                                                    18

<210>  11928
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11928
gtaagttctg tccaagcc                                                    18

<210>  11929
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11929
gtaagttctg tccaagcc                                                    18

<210>  11930
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11930
gtaagttctg tccaagcc                                                    18

<210>  11931
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11931
gtaagttctg tccaagcc                                                    18

<210>  11932
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11932
gtaagttctg tccaagcc                                                    18

<210>  11933
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11933
gtaagttctg tccaagcc                                                    18

<210>  11934
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  11934
gtaagttctg tccaagcc                                                    18

<210>  11935
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11935
gtaagttctg tccaagcc                                                    18

<210>  11936
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11936
gtaagttctg tccaagcc                                                    18

<210>  11937
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11937
agtcggtaag ttctgtcc                                                    18

<210>  11938
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11938
agtcggtaag ttctgtcc                                                    18

<210>  11939
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11939
agtcggtaag ttctgtcc                                                    18

<210>  11940
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11940
agtcggtaag ttctgtcc                                                    18

<210>  11941
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11941
agtcggtaag ttctgtcc                                                    18

<210>  11942
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11942
agtcggtaag ttctgtcc                                                    18

<210>  11943
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11943
agtcggtaag ttctgtcc                                                    18

<210>  11944
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11944
agtcggtaag ttctgtcc                                                    18

<210>  11945
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11945
agtcggtaag ttctgtcc                                                    18

<210>  11946
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11946
agtcggtaag ttctgtcc                                                    18

<210>  11947
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11947
agtcggtaag ttctgtcc                                                    18

<210>  11948
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11948
agtcggtaag ttctgtcc                                                    18

<210>  11949
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11949
agtcggtaag ttctgtcc                                                    18

<210>  11950
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11950
agtcggtaag ttctgtcc                                                    18

<210>  11951
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11951
agtcggtaag ttctgtcc                                                    18

<210>  11952
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11952
agtcggtaag ttctgtcc                                                    18

<210>  11953
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11953
agtcggtaag ttctgtcc                                                    18

<210>  11954
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11954
agtcggtaag ttctgtcc                                                    18

<210>  11955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  11955
agtcggtaag ttctgtcc                                                    18

<210>  11956
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  11956
agtcggtaag ttctgtcc                                                    18

<210>  11957
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11957
agtcggtaag ttctgtcc                                                    18

<210>  11958
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11958
ctgtccaagc ccggttga                                                    18

<210>  11959
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11959
ctgtccaagc ccggttga                                                    18

<210>  11960
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11960
ctgtccaagc ccggttga                                                    18

<210>  11961
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11961
ctgtccaagc ccggttga                                                    18

<210>  11962
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11962
ctgtccaagc ccggttga                                                    18

<210>  11963
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11963
ctgtccaagc ccggttga                                                    18

<210>  11964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11964
ctgtccaagc ccggttga                                                    18

<210>  11965
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11965
ctgtccaagc ccggttga                                                    18

<210>  11966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11966
ctgtccaagc ccggttga                                                    18

<210>  11967
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11967
ctgtccaagc ccggttga                                                    18

<210>  11968
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11968
ctgtccaagc ccggttga                                                    18

<210>  11969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11969
ctgtccaagc ccggttga                                                    18

<210>  11970
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  11970
ctgtccaagc ccggttga                                                    18

<210>  11971
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11971
ctgtccaagc ccggttga                                                    18

<210>  11972
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  11972
ctgtccaagc ccggttga                                                    18

<210>  11973
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11973
ctgtccaagc ccggttga                                                    18

<210>  11974
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11974
ctgtccaagc ccggttga                                                    18

<210>  11975
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11975
ctgtccaagc ccggttga                                                    18

<210>  11976
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11976
ctgtccaagc ccggttga                                                    18

<210>  11977
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11977
ctgtccaagc ccggttga                                                    18

<210>  11978
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11978
ctgtccaagc ccggttga                                                    18

<210>  11979
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11979
ctgtccaagc ccggttga                                                    18

<210>  11980
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11980
ctgtccaagc ccggttga                                                    18

<210>  11981
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11981
ctgtccaagc ccggttga                                                    18

<210>  11982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11982
ctgtccaagc ccggttga                                                    18

<210>  11983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11983
ctgtccaagc ccggttga                                                    18

<210>  11984
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11984
ctgtccaagc ccggttga                                                    18

<210>  11985
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11985
ctgtccaagc ccggttga                                                    18

<210>  11986
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  11986
ctgtccaagc ccggttga                                                    18

<210>  11987
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11987
ctgtccaagc ccggttga                                                    18

<210>  11988
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11988
ctgtccaagc ccggttga                                                    18

<210>  11989
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11989
ctgtccaagc ccggttga                                                    18

<210>  11990
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11990
ctgtccaagc ccggttga                                                    18

<210>  11991
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11991
ctgtccaagc ccggttga                                                    18

<210>  11992
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11992
ctgtccaagc ccggttga                                                    18

<210>  11993
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11993
ctgtccaagc ccggttga                                                    18

<210>  11994
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  11994
ctgtccaagc ccggttga                                                    18

<210>  11995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  11995
ctgtccaagc ccggttga                                                    18

<210>  11996
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  11996
ctgtccaagc ccggttga                                                    18

<210>  11997
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11997
ctgtccaagc ccggttga                                                    18

<210>  11998
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  11998
ctgtccaagc ccggttga                                                    18

<210>  11999
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  11999
ctgtccaagc ccggttga                                                    18

<210>  12000
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12000
ctgtccaagc ccggttga                                                    18

<210>  12001
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  12001
ctgtccaagc ccggttga                                                    18

<210>  12002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12002
ctgtccaagc ccggttga                                                    18

<210>  12003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12003
tcaaggaaga tggcatttct                                                  20

<210>  12004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  12004
tcaaggaaga tggcatttct                                                  20

<210>  12005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12005
tcaaggaaga tggcatttct                                                  20

<210>  12006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12006
tcaaggaaga tggcatttct                                                  20

<210>  12007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12007
tcaaggaaga tggcatttct                                                  20

<210>  12008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12008
tcaaggaaga tggcatttct                                                  20

<210>  12009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12009
tcaaggaaga tggcatttct                                                  20

<210>  12010
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12010
tcaaggaaga tggcatttct ag                                               22

<210>  12011
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  12011
tcaaggaaga tggcatttct ag                                               22

<210>  12012
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12012
tcaaggaaga tggcatttct ag                                               22

<210>  12013
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12013
tcaaggaaga tggcatttct ag                                               22

<210>  12014
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12014
tcaaggaaga tggcatttct ag                                               22

<210>  12015
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12015
tcaaggaaga tggcatttct ag                                               22

<210>  12016
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12016
tcaaggaaga tggcatttct ag                                               22

<210>  12017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12017
tcaaggaaga tggcatttct                                                  20

<210>  12018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12018
tcaaggaaga tggcatttct                                                  20

<210>  12019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12019
tcaaggaaga tggcatttct                                                  20

<210>  12020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12020
tcaaggaaga tggcatttct                                                  20

<210>  12021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12021
tcaaggaaga tggcatttct                                                  20

<210>  12022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12022
tcaaggaaga tggcatttct                                                  20

<210>  12023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12023
tcaaggaaga tggcatttct                                                  20

<210>  12024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12024
tcaaggaaga tggcatttct                                                  20

<210>  12025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12025
tcaaggaaga tggcatttct                                                  20

<210>  12026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12026
tcaaggaaga tggcatttct                                                  20

<210>  12027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12027
tcaaggaaga tggcatttct                                                  20

<210>  12028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12028
tcaaggaaga tggcatttct                                                  20

<210>  12029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12029
tcaaggaaga tggcatttct                                                  20

<210>  12030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12030
tcaaggaaga tggcatttct                                                  20

<210>  12031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12031
tcaaggaaga tggcatttct                                                  20

<210>  12032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12032
tcaaggaaga tggcatttct                                                  20

<210>  12033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12033
tcaaggaaga tggcatttct                                                  20

<210>  12034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12034
tcaaggaaga tggcatttct                                                  20

<210>  12035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12035
tcaaggaaga tggcatttct                                                  20

<210>  12036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12036
tcaaggaaga tggcatttct                                                  20

<210>  12037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12037
tcaaggaaga tggcatttct                                                  20

<210>  12038
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12038
tcaaggaaga tggcatttct ag                                               22

<210>  12039
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12039
tcaaggaaga tggcatttct ag                                               22

<210>  12040
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12040
tcaaggaaga tggcatttct ag                                               22

<210>  12041
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12041
tcaaggaaga tggcatttct ag                                               22

<210>  12042
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12042
tcaaggaaga tggcatttct ag                                               22

<210>  12043
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12043
tcaaggaaga tggcatttct ag                                               22

<210>  12044
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12044
tcaaggaaga tggcatttct ag                                               22

<210>  12045
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12045
tcaaggaaga tggcatttct ag                                               22

<210>  12046
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12046
tcaaggaaga tggcatttct ag                                               22

<210>  12047
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12047
tcaaggaaga tggcatttct ag                                               22

<210>  12048
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12048
tcaaggaaga tggcatttct ag                                               22

<210>  12049
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12049
tcaaggaaga tggcatttct ag                                               22

<210>  12050
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12050
tcaaggaaga tggcatttct ag                                               22

<210>  12051
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12051
tcaaggaaga tggcatttct ag                                               22

<210>  12052
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12052
tcaaggaaga tggcatttct ag                                               22

<210>  12053
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12053
tcaaggaaga tggcatttct ag                                               22

<210>  12054
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12054
tcaaggaaga tggcatttct ag                                               22

<210>  12055
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12055
tcaaggaaga tggcatttct ag                                               22

<210>  12056
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12056
tcaaggaaga tggcatttct ag                                               22

<210>  12057
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12057
tcaaggaaga tggcatttct ag                                               22

<210>  12058
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  12058
tcaaggaaga tggcatttct ag                                               22

<210>  12059
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12059
ggtaagttct gtccaagc                                                    18

<210>  12060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12060
ggtaagttct gtccaagc                                                    18

<210>  12061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12061
ggtaagttct gtccaagc                                                    18

<210>  12062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12062
ggtaagttct gtccaagc                                                    18

<210>  12063
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12063
ggtaagttct gtccaagc                                                    18

<210>  12064
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12064
ggtaagttct gtccaagc                                                    18

<210>  12065
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12065
gtaagttctg tccaagcc                                                    18

<210>  12066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12066
gtaagttctg tccaagcc                                                    18

<210>  12067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12067
gtaagttctg tccaagcc                                                    18

<210>  12068
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12068
gtaagttctg tccaagcc                                                    18

<210>  12069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12069
gtaagttctg tccaagcc                                                    18

<210>  12070
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12070
gtaagttctg tccaagcc                                                    18

<210>  12071
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12071
gtaagttctg tccaagcc                                                    18

<210>  12072
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12072
agtcggtaag ttctgtcc                                                    18

<210>  12073
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12073
agtcggtaag ttctgtcc                                                    18

<210>  12074
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12074
agtcggtaag ttctgtcc                                                    18

<210>  12075
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12075
agtcggtaag ttctgtcc                                                    18

<210>  12076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12076
agtcggtaag ttctgtcc                                                    18

<210>  12077
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12077
agtcggtaag ttctgtcc                                                    18

<210>  12078
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12078
agtcggtaag ttctgtcc                                                    18

<210>  12079
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  12079
ctgtccaagc ccggttga                                                    18

<210>  12080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12080
ctgtccaagc ccggttga                                                    18

<210>  12081
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  12081
ctgtccaagc ccggttga                                                    18

<210>  12082
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  12082
ctgtccaagc ccggttga                                                    18

<210>  12083
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  12083
ctgtccaagc ccggttga                                                    18

<210>  12084
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12084
ctgtccaagc ccggttga                                                    18

<210>  12085
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12085
ctgtccaagc ccggttga                                                    18

<210>  12086
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12086
ctgtccaagc ccggttga                                                    18

<210>  12087
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12087
ctgtccaagc ccggttga                                                    18

<210>  12088
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12088
ctgtccaagc ccggttga                                                    18

<210>  12089
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12089
ggtaagttct gtccaagc                                                    18

<210>  12090
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12090
ggtaagttct gtccaagc                                                    18

<210>  12091
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12091
ggtaagttct gtccaagc                                                    18

<210>  12092
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12092
ggtaagttct gtccaagc                                                    18

<210>  12093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12093
ggtaagttct gtccaagc                                                    18

<210>  12094
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12094
ggtaagttct gtccaagc                                                    18

<210>  12095
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12095
ggtaagttct gtccaagc                                                    18

<210>  12096
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12096
ggtaagttct gtccaagc                                                    18

<210>  12097
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12097
ggtaagttct gtccaagc                                                    18

<210>  12098
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12098
ggtaagttct gtccaagc                                                    18

<210>  12099
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12099
ggtaagttct gtccaagc                                                    18

<210>  12100
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12100
ggtaagttct gtccaagc                                                    18

<210>  12101
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12101
ggtaagttct gtccaagc                                                    18

<210>  12102
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12102
ggtaagttct gtccaagc                                                    18

<210>  12103
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12103
ggtaagttct gtccaagc                                                    18

<210>  12104
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12104
gtaagttctg tccaagcc                                                    18

<210>  12105
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12105
gtaagttctg tccaagcc                                                    18

<210>  12106
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12106
gtaagttctg tccaagcc                                                    18

<210>  12107
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12107
gtaagttctg tccaagcc                                                    18

<210>  12108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12108
gtaagttctg tccaagcc                                                    18

<210>  12109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12109
gtaagttctg tccaagcc                                                    18

<210>  12110
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12110
gtaagttctg tccaagcc                                                    18

<210>  12111
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12111
gtaagttctg tccaagcc                                                    18

<210>  12112
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12112
gtaagttctg tccaagcc                                                    18

<210>  12113
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12113
gtaagttctg tccaagcc                                                    18

<210>  12114
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12114
gtaagttctg tccaagcc                                                    18

<210>  12115
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12115
gtaagttctg tccaagcc                                                    18

<210>  12116
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12116
gtaagttctg tccaagcc                                                    18

<210>  12117
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12117
gtaagttctg tccaagcc                                                    18

<210>  12118
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12118
gtaagttctg tccaagcc                                                    18

<210>  12119
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12119
gtaagttctg tccaagcc                                                    18

<210>  12120
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12120
gtaagttctg tccaagcc                                                    18

<210>  12121
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12121
gtaagttctg tccaagcc                                                    18

<210>  12122
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12122
gtaagttctg tccaagcc                                                    18

<210>  12123
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12123
gtaagttctg tccaagcc                                                    18

<210>  12124
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12124
gtaagttctg tccaagcc                                                    18

<210>  12125
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12125
agtcggtaag ttctgtcc                                                    18

<210>  12126
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12126
agtcggtaag ttctgtcc                                                    18

<210>  12127
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12127
agtcggtaag ttctgtcc                                                    18

<210>  12128
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12128
agtcggtaag ttctgtcc                                                    18

<210>  12129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12129
agtcggtaag ttctgtcc                                                    18

<210>  12130
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12130
agtcggtaag ttctgtcc                                                    18

<210>  12131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12131
agtcggtaag ttctgtcc                                                    18

<210>  12132
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12132
agtcggtaag ttctgtcc                                                    18

<210>  12133
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12133
agtcggtaag ttctgtcc                                                    18

<210>  12134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12134
agtcggtaag ttctgtcc                                                    18

<210>  12135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12135
agtcggtaag ttctgtcc                                                    18

<210>  12136
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12136
agtcggtaag ttctgtcc                                                    18

<210>  12137
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12137
agtcggtaag ttctgtcc                                                    18

<210>  12138
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12138
agtcggtaag ttctgtcc                                                    18

<210>  12139
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12139
agtcggtaag ttctgtcc                                                    18

<210>  12140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12140
agtcggtaag ttctgtcc                                                    18

<210>  12141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12141
agtcggtaag ttctgtcc                                                    18

<210>  12142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12142
agtcggtaag ttctgtcc                                                    18

<210>  12143
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12143
agtcggtaag ttctgtcc                                                    18

<210>  12144
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12144
agtcggtaag ttctgtcc                                                    18

<210>  12145
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12145
agtcggtaag ttctgtcc                                                    18

<210>  12146
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12146
ctgtccaagc ccggttga                                                    18

<210>  12147
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  12147
ctgtccaagc ccggttga                                                    18

<210>  12148
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12148
ctgtccaagc ccggttga                                                    18

<210>  12149
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12149
ctgtccaagc ccggttga                                                    18

<210>  12150
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12150
ctgtccaagc ccggttga                                                    18

<210>  12151
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12151
ctgtccaagc ccggttga                                                    18

<210>  12152
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12152
ctgtccaagc ccggttga                                                    18

<210>  12153
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  12153
ctgtccaagc ccggttga                                                    18

<210>  12154
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12154
ctgtccaagc ccggttga                                                    18

<210>  12155
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12155
ctgtccaagc ccggttga                                                    18

<210>  12156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12156
ctgtccaagc ccggttga                                                    18

<210>  12157
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12157
ctgtccaagc ccggttga                                                    18

<210>  12158
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  12158
ctgtccaagc ccggttga                                                    18

<210>  12159
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  12159
ctgtccaagc ccggttga                                                    18

<210>  12160
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  12160
ctgtccaagc ccggttga                                                    18

<210>  12161
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12161
ctgtccaagc ccggttga                                                    18

<210>  12162
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12162
ctgtccaagc ccggttga                                                    18

<210>  12163
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  12163
ctgtccaagc ccggttga                                                    18

<210>  12164
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12164
ctgtccaagc ccggttga                                                    18

<210>  12165
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12165
ctgtccaagc ccggttga                                                    18

<210>  12166
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12166
ctgtccaagc ccggttga                                                    18

<210>  12167
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12167
ctgtccaagc ccggttga                                                    18

<210>  12168
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12168
ctgtccaagc ccggttga                                                    18

<210>  12169
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12169
ctgtccaagc ccggttga                                                    18

<210>  12170
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12170
ctgtccaagc ccggttga                                                    18

<210>  12171
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  12171
ctgtccaagc ccggttga                                                    18

<210>  12172
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12172
ctgtccaagc ccggttga                                                    18

<210>  12173
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12173
ctgtccaagc ccggttga                                                    18

<210>  12174
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  12174
ctgtccaagc ccggttga                                                    18

<210>  12175
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12175
ctgtccaagc ccggttga                                                    18

<210>  12176
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12176
ctgtccaagc ccggttga                                                    18

<210>  12177
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12177
ctgtccaagc ccggttga                                                    18

<210>  12178
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  12178
ctgtccaagc ccggttga                                                    18

<210>  12179
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  12179
ctgtccaagc ccggttga                                                    18

<210>  12180
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12180
ctgtccaagc ccggttga                                                    18

<210>  12181
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12181
ctgtccaagc ccggttga                                                    18

<210>  12182
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12182
ctgtccaagc ccggttga                                                    18

<210>  12183
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  12183
ctgtccaagc ccggttga                                                    18

<210>  12184
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  12184
ctgtccaagc ccggttga                                                    18

<210>  12185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12185
ctgtccaagc ccggttga                                                    18

<210>  12186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12186
ctgtccaagc ccggttga                                                    18

<210>  12187
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  12187
ctgtccaagc ccggttga                                                    18

<210>  12188
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  12188
ctgtccaagc ccggttga                                                    18

<210>  12189
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  12189
ctgtccaagc ccggttga                                                    18

<210>  12190
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  12190
ctgtccaagc ccggttga                                                    18

<210>  12191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12191
tcaaggaaga tggcatttct                                                  20

<210>  12192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12192
tcaaggaaga tggcatttct                                                  20

<210>  12193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12193
tcaaggaaga tggcatttct                                                  20

<210>  12194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12194
tcaaggaaga tggcatttct                                                  20

<210>  12195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12195
tcaaggaaga tggcatttct                                                  20

<210>  12196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12196
tcaaggaaga tggcatttct                                                  20

<210>  12197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12197
tcaaggaaga tggcatttct                                                  20

<210>  12198
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12198
tcaaggaaga tggcatttct ag                                               22

<210>  12199
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12199
tcaaggaaga tggcatttct ag                                               22

<210>  12200
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12200
tcaaggaaga tggcatttct ag                                               22

<210>  12201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12201
tcaaggaaga tggcatttct ag                                               22

<210>  12202
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12202
tcaaggaaga tggcatttct ag                                               22

<210>  12203
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12203
tcaaggaaga tggcatttct ag                                               22

<210>  12204
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12204
tcaaggaaga tggcatttct ag                                               22

<210>  12205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12205
tcaaggaaga tggcatttct                                                  20

<210>  12206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12206
tcaaggaaga tggcatttct                                                  20

<210>  12207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12207
tcaaggaaga tggcatttct                                                  20

<210>  12208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12208
tcaaggaaga tggcatttct                                                  20

<210>  12209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12209
tcaaggaaga tggcatttct                                                  20

<210>  12210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12210
tcaaggaaga tggcatttct                                                  20

<210>  12211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12211
tcaaggaaga tggcatttct                                                  20

<210>  12212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12212
tcaaggaaga tggcatttct                                                  20

<210>  12213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12213
tcaaggaaga tggcatttct                                                  20

<210>  12214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12214
tcaaggaaga tggcatttct                                                  20

<210>  12215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12215
tcaaggaaga tggcatttct                                                  20

<210>  12216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12216
tcaaggaaga tggcatttct                                                  20

<210>  12217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12217
tcaaggaaga tggcatttct                                                  20

<210>  12218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12218
tcaaggaaga tggcatttct                                                  20

<210>  12219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12219
tcaaggaaga tggcatttct                                                  20

<210>  12220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12220
tcaaggaaga tggcatttct                                                  20

<210>  12221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12221
tcaaggaaga tggcatttct                                                  20

<210>  12222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12222
tcaaggaaga tggcatttct                                                  20

<210>  12223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12223
tcaaggaaga tggcatttct                                                  20

<210>  12224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12224
tcaaggaaga tggcatttct                                                  20

<210>  12225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12225
tcaaggaaga tggcatttct                                                  20

<210>  12226
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12226
tcaaggaaga tggcatttct ag                                               22

<210>  12227
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12227
tcaaggaaga tggcatttct ag                                               22

<210>  12228
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12228
tcaaggaaga tggcatttct ag                                               22

<210>  12229
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12229
tcaaggaaga tggcatttct ag                                               22

<210>  12230
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12230
tcaaggaaga tggcatttct ag                                               22

<210>  12231
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12231
tcaaggaaga tggcatttct ag                                               22

<210>  12232
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12232
tcaaggaaga tggcatttct ag                                               22

<210>  12233
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12233
tcaaggaaga tggcatttct ag                                               22

<210>  12234
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12234
tcaaggaaga tggcatttct ag                                               22

<210>  12235
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12235
tcaaggaaga tggcatttct ag                                               22

<210>  12236
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12236
tcaaggaaga tggcatttct ag                                               22

<210>  12237
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12237
tcaaggaaga tggcatttct ag                                               22

<210>  12238
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12238
tcaaggaaga tggcatttct ag                                               22

<210>  12239
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12239
tcaaggaaga tggcatttct ag                                               22

<210>  12240
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12240
tcaaggaaga tggcatttct ag                                               22

<210>  12241
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12241
tcaaggaaga tggcatttct ag                                               22

<210>  12242
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12242
tcaaggaaga tggcatttct ag                                               22

<210>  12243
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12243
tcaaggaaga tggcatttct ag                                               22

<210>  12244
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12244
tcaaggaaga tggcatttct ag                                               22

<210>  12245
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12245
tcaaggaaga tggcatttct ag                                               22

<210>  12246
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  12246
tcaaggaaga tggcatttct ag                                               22

<210>  12247
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12247
gguaaguucu guccaagc                                                    18

<210>  12248
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12248
gguaaguucu guccaagc                                                    18

<210>  12249
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12249
gguaaguucu guccaagc                                                    18

<210>  12250
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12250
gguaaguucu guccaagc                                                    18

<210>  12251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12251
gguaaguucu guccaagc                                                    18

<210>  12252
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12252
gguaaguucu guccaagc                                                    18

<210>  12253
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12253
guaaguucug uccaagcc                                                    18

<210>  12254
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12254
guaaguucug uccaagcc                                                    18

<210>  12255
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12255
guaaguucug uccaagcc                                                    18

<210>  12256
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12256
guaaguucug uccaagcc                                                    18

<210>  12257
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12257
guaaguucug uccaagcc                                                    18

<210>  12258
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12258
guaaguucug uccaagcc                                                    18

<210>  12259
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12259
agucgguaag uucugucc                                                    18

<210>  12260
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12260
agucgguaag uucugucc                                                    18

<210>  12261
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12261
agucgguaag uucugucc                                                    18

<210>  12262
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12262
agucgguaag uucugucc                                                    18

<210>  12263
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12263
agucgguaag uucugucc                                                    18

<210>  12264
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12264
agucgguaag uucugucc                                                    18

<210>  12265
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12265
agucgguaag uucugucc                                                    18

<210>  12266
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12266
cuguccaagc ccgguuga                                                    18

<210>  12267
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12267
cuguccaagc ccgguuga                                                    18

<210>  12268
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12268
cuguccaagc ccgguuga                                                    18

<210>  12269
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12269
cuguccaagc ccgguuga                                                    18

<210>  12270
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12270
cuguccaagc ccgguuga                                                    18

<210>  12271
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12271
cuguccaagc ccgguuga                                                    18

<210>  12272
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12272
cuguccaagc ccgguuga                                                    18

<210>  12273
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12273
cuguccaagc ccgguuga                                                    18

<210>  12274
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12274
cuguccaagc ccgguuga                                                    18

<210>  12275
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12275
gguaaguucu guccaagc                                                    18

<210>  12276
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12276
gguaaguucu guccaagc                                                    18

<210>  12277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12277
gguaaguucu guccaagc                                                    18

<210>  12278
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12278
gguaaguucu guccaagc                                                    18

<210>  12279
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12279
gguaaguucu guccaagc                                                    18

<210>  12280
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12280
gguaaguucu guccaagc                                                    18

<210>  12281
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12281
gguaaguucu guccaagc                                                    18

<210>  12282
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12282
gguaaguucu guccaagc                                                    18

<210>  12283
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12283
gguaaguucu guccaagc                                                    18

<210>  12284
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12284
gguaaguucu guccaagc                                                    18

<210>  12285
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12285
gguaaguucu guccaagc                                                    18

<210>  12286
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12286
gguaaguucu guccaagc                                                    18

<210>  12287
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12287
gguaaguucu guccaagc                                                    18

<210>  12288
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12288
gguaaguucu guccaagc                                                    18

<210>  12289
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12289
gguaaguucu guccaagc                                                    18

<210>  12290
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12290
guaaguucug uccaagcc                                                    18

<210>  12291
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12291
guaaguucug uccaagcc                                                    18

<210>  12292
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12292
guaaguucug uccaagcc                                                    18

<210>  12293
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12293
guaaguucug uccaagcc                                                    18

<210>  12294
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12294
guaaguucug uccaagcc                                                    18

<210>  12295
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12295
guaaguucug uccaagcc                                                    18

<210>  12296
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12296
guaaguucug uccaagcc                                                    18

<210>  12297
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12297
guaaguucug uccaagcc                                                    18

<210>  12298
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12298
guaaguucug uccaagcc                                                    18

<210>  12299
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12299
guaaguucug uccaagcc                                                    18

<210>  12300
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12300
guaaguucug uccaagcc                                                    18

<210>  12301
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12301
guaaguucug uccaagcc                                                    18

<210>  12302
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12302
guaaguucug uccaagcc                                                    18

<210>  12303
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12303
guaaguucug uccaagcc                                                    18

<210>  12304
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12304
guaaguucug uccaagcc                                                    18

<210>  12305
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12305
agucgguaag uucugucc                                                    18

<210>  12306
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12306
agucgguaag uucugucc                                                    18

<210>  12307
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12307
agucgguaag uucugucc                                                    18

<210>  12308
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12308
agucgguaag uucugucc                                                    18

<210>  12309
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12309
agucgguaag uucugucc                                                    18

<210>  12310
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12310
agucgguaag uucugucc                                                    18

<210>  12311
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12311
agucgguaag uucugucc                                                    18

<210>  12312
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12312
agucgguaag uucugucc                                                    18

<210>  12313
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12313
agucgguaag uucugucc                                                    18

<210>  12314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12314
agucgguaag uucugucc                                                    18

<210>  12315
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12315
agucgguaag uucugucc                                                    18

<210>  12316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12316
agucgguaag uucugucc                                                    18

<210>  12317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12317
agucgguaag uucugucc                                                    18

<210>  12318
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12318
agucgguaag uucugucc                                                    18

<210>  12319
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12319
agucgguaag uucugucc                                                    18

<210>  12320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12320
agucgguaag uucugucc                                                    18

<210>  12321
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12321
agucgguaag uucugucc                                                    18

<210>  12322
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12322
agucgguaag uucugucc                                                    18

<210>  12323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12323
agucgguaag uucugucc                                                    18

<210>  12324
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12324
agucgguaag uucugucc                                                    18

<210>  12325
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12325
agucgguaag uucugucc                                                    18

<210>  12326
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12326
cuguccaagc ccgguuga                                                    18

<210>  12327
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12327
cuguccaagc ccgguuga                                                    18

<210>  12328
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12328
cuguccaagc ccgguuga                                                    18

<210>  12329
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12329
cuguccaagc ccgguuga                                                    18

<210>  12330
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12330
cuguccaagc ccgguuga                                                    18

<210>  12331
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12331
cuguccaagc ccgguuga                                                    18

<210>  12332
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12332
cuguccaagc ccgguuga                                                    18

<210>  12333
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12333
cuguccaagc ccgguuga                                                    18

<210>  12334
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12334
cuguccaagc ccgguuga                                                    18

<210>  12335
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12335
cuguccaagc ccgguuga                                                    18

<210>  12336
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12336
cuguccaagc ccgguuga                                                    18

<210>  12337
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12337
cuguccaagc ccgguuga                                                    18

<210>  12338
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12338
cuguccaagc ccgguuga                                                    18

<210>  12339
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12339
cuguccaagc ccgguuga                                                    18

<210>  12340
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12340
cuguccaagc ccgguuga                                                    18

<210>  12341
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12341
cuguccaagc ccgguuga                                                    18

<210>  12342
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12342
cuguccaagc ccgguuga                                                    18

<210>  12343
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12343
cuguccaagc ccgguuga                                                    18

<210>  12344
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12344
cuguccaagc ccgguuga                                                    18

<210>  12345
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12345
cuguccaagc ccgguuga                                                    18

<210>  12346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12346
cuguccaagc ccgguuga                                                    18

<210>  12347
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12347
cuguccaagc ccgguuga                                                    18

<210>  12348
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12348
cuguccaagc ccgguuga                                                    18

<210>  12349
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12349
cuguccaagc ccgguuga                                                    18

<210>  12350
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12350
cuguccaagc ccgguuga                                                    18

<210>  12351
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12351
cuguccaagc ccgguuga                                                    18

<210>  12352
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12352
cuguccaagc ccgguuga                                                    18

<210>  12353
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12353
cuguccaagc ccgguuga                                                    18

<210>  12354
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12354
cuguccaagc ccgguuga                                                    18

<210>  12355
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12355
cuguccaagc ccgguuga                                                    18

<210>  12356
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12356
cuguccaagc ccgguuga                                                    18

<210>  12357
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12357
cuguccaagc ccgguuga                                                    18

<210>  12358
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12358
cuguccaagc ccgguuga                                                    18

<210>  12359
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12359
cuguccaagc ccgguuga                                                    18

<210>  12360
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12360
cuguccaagc ccgguuga                                                    18

<210>  12361
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12361
cuguccaagc ccgguuga                                                    18

<210>  12362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12362
ucaaggaaga uggcauuuct                                                  20

<210>  12363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12363
ucaaggaaga uggcauuuct                                                  20

<210>  12364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12364
ucaaggaaga uggcauuuct                                                  20

<210>  12365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12365
ucaaggaaga uggcauuuct                                                  20

<210>  12366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12366
ucaaggaaga uggcauuuct                                                  20

<210>  12367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12367
ucaaggaaga uggcauuuct                                                  20

<210>  12368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12368
ucaaggaaga uggcauuuct                                                  20

<210>  12369
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12369
ucaaggaaga uggcauuucu ag                                               22

<210>  12370
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12370
ucaaggaaga uggcauuucu ag                                               22

<210>  12371
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12371
ucaaggaaga uggcauuucu ag                                               22

<210>  12372
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12372
ucaaggaaga uggcauuucu ag                                               22

<210>  12373
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12373
ucaaggaaga uggcauuucu ag                                               22

<210>  12374
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12374
ucaaggaaga uggcauuucu ag                                               22

<210>  12375
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12375
ucaaggaaga uggcauuucu ag                                               22

<210>  12376
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12376
ucaaggaaga uggcauuucu ag                                               22

<210>  12377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12377
ucaaggaaga uggcauuuct                                                  20

<210>  12378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12378
ucaaggaaga uggcauuuct                                                  20

<210>  12379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12379
ucaaggaaga uggcauuuct                                                  20

<210>  12380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12380
ucaaggaaga uggcauuuct                                                  20

<210>  12381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12381
ucaaggaaga uggcauuuct                                                  20

<210>  12382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12382
ucaaggaaga uggcauuuct                                                  20

<210>  12383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12383
ucaaggaaga uggcauuuct                                                  20

<210>  12384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12384
ucaaggaaga uggcauuuct                                                  20

<210>  12385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12385
ucaaggaaga uggcauuuct                                                  20

<210>  12386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12386
ucaaggaaga uggcauuuct                                                  20

<210>  12387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12387
ucaaggaaga uggcauuuct                                                  20

<210>  12388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12388
ucaaggaaga uggcauuuct                                                  20

<210>  12389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12389
ucaaggaaga uggcauuuct                                                  20

<210>  12390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12390
ucaaggaaga uggcauuuct                                                  20

<210>  12391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12391
ucaaggaaga uggcauuuct                                                  20

<210>  12392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12392
ucaaggaaga uggcauuuct                                                  20

<210>  12393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12393
ucaaggaaga uggcauuuct                                                  20

<210>  12394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12394
ucaaggaaga uggcauuuct                                                  20

<210>  12395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12395
ucaaggaaga uggcauuuct                                                  20

<210>  12396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12396
ucaaggaaga uggcauuuct                                                  20

<210>  12397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12397
ucaaggaaga uggcauuuct                                                  20

<210>  12398
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12398
ucaaggaaga uggcauuucu ag                                               22

<210>  12399
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12399
ucaaggaaga uggcauuucu ag                                               22

<210>  12400
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12400
ucaaggaaga uggcauuucu ag                                               22

<210>  12401
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12401
ucaaggaaga uggcauuucu ag                                               22

<210>  12402
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12402
ucaaggaaga uggcauuucu ag                                               22

<210>  12403
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12403
ucaaggaaga uggcauuucu ag                                               22

<210>  12404
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12404
ucaaggaaga uggcauuucu ag                                               22

<210>  12405
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12405
ucaaggaaga uggcauuucu ag                                               22

<210>  12406
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12406
ucaaggaaga uggcauuucu ag                                               22

<210>  12407
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12407
ucaaggaaga uggcauuucu ag                                               22

<210>  12408
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12408
ucaaggaaga uggcauuucu ag                                               22

<210>  12409
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12409
ucaaggaaga uggcauuucu ag                                               22

<210>  12410
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12410
ucaaggaaga uggcauuucu ag                                               22

<210>  12411
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12411
ucaaggaaga uggcauuucu ag                                               22

<210>  12412
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12412
ucaaggaaga uggcauuucu ag                                               22

<210>  12413
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12413
ucaaggaaga uggcauuucu ag                                               22

<210>  12414
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12414
ucaaggaaga uggcauuucu ag                                               22

<210>  12415
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12415
ucaaggaaga uggcauuucu ag                                               22

<210>  12416
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12416
ucaaggaaga uggcauuucu ag                                               22

<210>  12417
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12417
ucaaggaaga uggcauuucu ag                                               22

<210>  12418
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12418
ucaaggaaga uggcauuucu ag                                               22

<210>  12419
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12419
ucaaggaaga uggcauuucu ag                                               22

<210>  12420
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12420
ucaaggaaga uggcauuucu ag                                               22

<210>  12421
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12421
ucaaggaaga uggcauuucu ag                                               22

<210>  12422
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12422
ucaaggaaga uggcauuucu ag                                               22

<210>  12423
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12423
ucaaggaaga uggcauuucu ag                                               22

<210>  12424
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12424
ucaaggaaga uggcauuucu ag                                               22

<210>  12425
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12425
ucaaggaaga uggcauuucu ag                                               22

<210>  12426
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12426
gguaaguucu guccaagc                                                    18

<210>  12427
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12427
gguaaguucu guccaagc                                                    18

<210>  12428
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12428
gguaaguucu guccaagc                                                    18

<210>  12429
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12429
gguaaguucu guccaagc                                                    18

<210>  12430
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12430
gguaaguucu guccaagc                                                    18

<210>  12431
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12431
gguaaguucu guccaagc                                                    18

<210>  12432
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12432
guaaguucug uccaagcc                                                    18

<210>  12433
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12433
guaaguucug uccaagcc                                                    18

<210>  12434
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12434
guaaguucug uccaagcc                                                    18

<210>  12435
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12435
guaaguucug uccaagcc                                                    18

<210>  12436
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12436
guaaguucug uccaagcc                                                    18

<210>  12437
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12437
guaaguucug uccaagcc                                                    18

<210>  12438
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12438
agucgguaag uucugucc                                                    18

<210>  12439
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12439
agucgguaag uucugucc                                                    18

<210>  12440
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12440
agucgguaag uucugucc                                                    18

<210>  12441
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12441
agucgguaag uucugucc                                                    18

<210>  12442
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12442
agucgguaag uucugucc                                                    18

<210>  12443
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12443
agucgguaag uucugucc                                                    18

<210>  12444
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12444
agucgguaag uucugucc                                                    18

<210>  12445
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12445
cuguccaagc ccgguuga                                                    18

<210>  12446
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12446
cuguccaagc ccgguuga                                                    18

<210>  12447
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12447
cuguccaagc ccgguuga                                                    18

<210>  12448
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12448
cuguccaagc ccgguuga                                                    18

<210>  12449
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12449
cuguccaagc ccgguuga                                                    18

<210>  12450
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12450
cuguccaagc ccgguuga                                                    18

<210>  12451
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12451
cuguccaagc ccgguuga                                                    18

<210>  12452
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12452
cuguccaagc ccgguuga                                                    18

<210>  12453
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12453
cuguccaagc ccgguuga                                                    18

<210>  12454
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12454
gguaaguucu guccaagc                                                    18

<210>  12455
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12455
gguaaguucu guccaagc                                                    18

<210>  12456
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12456
gguaaguucu guccaagc                                                    18

<210>  12457
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12457
gguaaguucu guccaagc                                                    18

<210>  12458
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12458
gguaaguucu guccaagc                                                    18

<210>  12459
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12459
gguaaguucu guccaagc                                                    18

<210>  12460
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12460
gguaaguucu guccaagc                                                    18

<210>  12461
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12461
gguaaguucu guccaagc                                                    18

<210>  12462
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12462
gguaaguucu guccaagc                                                    18

<210>  12463
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12463
gguaaguucu guccaagc                                                    18

<210>  12464
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12464
gguaaguucu guccaagc                                                    18

<210>  12465
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12465
gguaaguucu guccaagc                                                    18

<210>  12466
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12466
gguaaguucu guccaagc                                                    18

<210>  12467
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12467
gguaaguucu guccaagc                                                    18

<210>  12468
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12468
gguaaguucu guccaagc                                                    18

<210>  12469
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12469
guaaguucug uccaagcc                                                    18

<210>  12470
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12470
guaaguucug uccaagcc                                                    18

<210>  12471
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12471
guaaguucug uccaagcc                                                    18

<210>  12472
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12472
guaaguucug uccaagcc                                                    18

<210>  12473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12473
guaaguucug uccaagcc                                                    18

<210>  12474
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12474
guaaguucug uccaagcc                                                    18

<210>  12475
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12475
guaaguucug uccaagcc                                                    18

<210>  12476
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12476
guaaguucug uccaagcc                                                    18

<210>  12477
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12477
guaaguucug uccaagcc                                                    18

<210>  12478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12478
guaaguucug uccaagcc                                                    18

<210>  12479
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12479
guaaguucug uccaagcc                                                    18

<210>  12480
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12480
guaaguucug uccaagcc                                                    18

<210>  12481
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12481
guaaguucug uccaagcc                                                    18

<210>  12482
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12482
guaaguucug uccaagcc                                                    18

<210>  12483
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12483
guaaguucug uccaagcc                                                    18

<210>  12484
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12484
agucgguaag uucugucc                                                    18

<210>  12485
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12485
agucgguaag uucugucc                                                    18

<210>  12486
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12486
agucgguaag uucugucc                                                    18

<210>  12487
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12487
agucgguaag uucugucc                                                    18

<210>  12488
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12488
agucgguaag uucugucc                                                    18

<210>  12489
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12489
agucgguaag uucugucc                                                    18

<210>  12490
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12490
agucgguaag uucugucc                                                    18

<210>  12491
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12491
agucgguaag uucugucc                                                    18

<210>  12492
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12492
agucgguaag uucugucc                                                    18

<210>  12493
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12493
agucgguaag uucugucc                                                    18

<210>  12494
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12494
agucgguaag uucugucc                                                    18

<210>  12495
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12495
agucgguaag uucugucc                                                    18

<210>  12496
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12496
agucgguaag uucugucc                                                    18

<210>  12497
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12497
agucgguaag uucugucc                                                    18

<210>  12498
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12498
agucgguaag uucugucc                                                    18

<210>  12499
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12499
agucgguaag uucugucc                                                    18

<210>  12500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12500
agucgguaag uucugucc                                                    18

<210>  12501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12501
agucgguaag uucugucc                                                    18

<210>  12502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12502
agucgguaag uucugucc                                                    18

<210>  12503
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12503
agucgguaag uucugucc                                                    18

<210>  12504
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12504
agucgguaag uucugucc                                                    18

<210>  12505
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12505
cuguccaagc ccgguuga                                                    18

<210>  12506
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12506
cuguccaagc ccgguuga                                                    18

<210>  12507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12507
cuguccaagc ccgguuga                                                    18

<210>  12508
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12508
cuguccaagc ccgguuga                                                    18

<210>  12509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12509
cuguccaagc ccgguuga                                                    18

<210>  12510
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12510
cuguccaagc ccgguuga                                                    18

<210>  12511
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12511
cuguccaagc ccgguuga                                                    18

<210>  12512
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12512
cuguccaagc ccgguuga                                                    18

<210>  12513
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12513
cuguccaagc ccgguuga                                                    18

<210>  12514
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12514
cuguccaagc ccgguuga                                                    18

<210>  12515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12515
cuguccaagc ccgguuga                                                    18

<210>  12516
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12516
cuguccaagc ccgguuga                                                    18

<210>  12517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12517
cuguccaagc ccgguuga                                                    18

<210>  12518
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12518
cuguccaagc ccgguuga                                                    18

<210>  12519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12519
cuguccaagc ccgguuga                                                    18

<210>  12520
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12520
cuguccaagc ccgguuga                                                    18

<210>  12521
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12521
cuguccaagc ccgguuga                                                    18

<210>  12522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12522
cuguccaagc ccgguuga                                                    18

<210>  12523
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12523
cuguccaagc ccgguuga                                                    18

<210>  12524
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12524
cuguccaagc ccgguuga                                                    18

<210>  12525
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12525
cuguccaagc ccgguuga                                                    18

<210>  12526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12526
cuguccaagc ccgguuga                                                    18

<210>  12527
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12527
cuguccaagc ccgguuga                                                    18

<210>  12528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12528
cuguccaagc ccgguuga                                                    18

<210>  12529
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12529
cuguccaagc ccgguuga                                                    18

<210>  12530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12530
cuguccaagc ccgguuga                                                    18

<210>  12531
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12531
cuguccaagc ccgguuga                                                    18

<210>  12532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12532
cuguccaagc ccgguuga                                                    18

<210>  12533
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12533
cuguccaagc ccgguuga                                                    18

<210>  12534
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12534
cuguccaagc ccgguuga                                                    18

<210>  12535
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12535
cuguccaagc ccgguuga                                                    18

<210>  12536
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12536
cuguccaagc ccgguuga                                                    18

<210>  12537
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12537
cuguccaagc ccgguuga                                                    18

<210>  12538
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12538
cuguccaagc ccgguuga                                                    18

<210>  12539
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12539
cuguccaagc ccgguuga                                                    18

<210>  12540
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12540
cuguccaagc ccgguuga                                                    18

<210>  12541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12541
ucaaggaaga uggcauuuct                                                  20

<210>  12542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12542
ucaaggaaga uggcauuuct                                                  20

<210>  12543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12543
ucaaggaaga uggcauuuct                                                  20

<210>  12544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12544
ucaaggaaga uggcauuuct                                                  20

<210>  12545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12545
ucaaggaaga uggcauuuct                                                  20

<210>  12546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12546
ucaaggaaga uggcauuuct                                                  20

<210>  12547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12547
ucaaggaaga uggcauuuct                                                  20

<210>  12548
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12548
ucaaggaaga uggcauuucu ag                                               22

<210>  12549
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12549
ucaaggaaga uggcauuucu ag                                               22

<210>  12550
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12550
ucaaggaaga uggcauuucu ag                                               22

<210>  12551
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12551
ucaaggaaga uggcauuucu ag                                               22

<210>  12552
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12552
ucaaggaaga uggcauuucu ag                                               22

<210>  12553
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12553
ucaaggaaga uggcauuucu ag                                               22

<210>  12554
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12554
ucaaggaaga uggcauuucu ag                                               22

<210>  12555
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12555
ucaaggaaga uggcauuucu ag                                               22

<210>  12556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12556
ucaaggaaga uggcauuuct                                                  20

<210>  12557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12557
ucaaggaaga uggcauuuct                                                  20

<210>  12558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12558
ucaaggaaga uggcauuuct                                                  20

<210>  12559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12559
ucaaggaaga uggcauuuct                                                  20

<210>  12560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12560
ucaaggaaga uggcauuuct                                                  20

<210>  12561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12561
ucaaggaaga uggcauuuct                                                  20

<210>  12562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12562
ucaaggaaga uggcauuuct                                                  20

<210>  12563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12563
ucaaggaaga uggcauuuct                                                  20

<210>  12564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12564
ucaaggaaga uggcauuuct                                                  20

<210>  12565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12565
ucaaggaaga uggcauuuct                                                  20

<210>  12566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12566
ucaaggaaga uggcauuuct                                                  20

<210>  12567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12567
ucaaggaaga uggcauuuct                                                  20

<210>  12568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12568
ucaaggaaga uggcauuuct                                                  20

<210>  12569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12569
ucaaggaaga uggcauuuct                                                  20

<210>  12570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12570
ucaaggaaga uggcauuuct                                                  20

<210>  12571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12571
ucaaggaaga uggcauuuct                                                  20

<210>  12572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12572
ucaaggaaga uggcauuuct                                                  20

<210>  12573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12573
ucaaggaaga uggcauuuct                                                  20

<210>  12574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12574
ucaaggaaga uggcauuuct                                                  20

<210>  12575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12575
ucaaggaaga uggcauuuct                                                  20

<210>  12576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12576
ucaaggaaga uggcauuuct                                                  20

<210>  12577
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12577
ucaaggaaga uggcauuucu ag                                               22

<210>  12578
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12578
ucaaggaaga uggcauuucu ag                                               22

<210>  12579
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12579
ucaaggaaga uggcauuucu ag                                               22

<210>  12580
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12580
ucaaggaaga uggcauuucu ag                                               22

<210>  12581
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12581
ucaaggaaga uggcauuucu ag                                               22

<210>  12582
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12582
ucaaggaaga uggcauuucu ag                                               22

<210>  12583
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12583
ucaaggaaga uggcauuucu ag                                               22

<210>  12584
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12584
ucaaggaaga uggcauuucu ag                                               22

<210>  12585
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12585
ucaaggaaga uggcauuucu ag                                               22

<210>  12586
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12586
ucaaggaaga uggcauuucu ag                                               22

<210>  12587
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12587
ucaaggaaga uggcauuucu ag                                               22

<210>  12588
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12588
ucaaggaaga uggcauuucu ag                                               22

<210>  12589
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12589
ucaaggaaga uggcauuucu ag                                               22

<210>  12590
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12590
ucaaggaaga uggcauuucu ag                                               22

<210>  12591
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12591
ucaaggaaga uggcauuucu ag                                               22

<210>  12592
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12592
ucaaggaaga uggcauuucu ag                                               22

<210>  12593
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12593
ucaaggaaga uggcauuucu ag                                               22

<210>  12594
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12594
ucaaggaaga uggcauuucu ag                                               22

<210>  12595
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12595
ucaaggaaga uggcauuucu ag                                               22

<210>  12596
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12596
ucaaggaaga uggcauuucu ag                                               22

<210>  12597
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12597
ucaaggaaga uggcauuucu ag                                               22

<210>  12598
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12598
ucaaggaaga uggcauuucu ag                                               22

<210>  12599
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12599
ucaaggaaga uggcauuucu ag                                               22

<210>  12600
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12600
ucaaggaaga uggcauuucu ag                                               22

<210>  12601
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12601
ucaaggaaga uggcauuucu ag                                               22

<210>  12602
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12602
ucaaggaaga uggcauuucu ag                                               22

<210>  12603
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12603
ucaaggaaga uggcauuucu ag                                               22

<210>  12604
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12604
ucaaggaaga uggcauuucu ag                                               22

<210>  12605
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12605
ggtaagttct gtccaagc                                                    18

<210>  12606
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12606
ggtaagttct gtccaagc                                                    18

<210>  12607
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12607
ggtaagttct gtccaagc                                                    18

<210>  12608
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12608
ggtaagttct gtccaagc                                                    18

<210>  12609
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12609
ggtaagttct gtccaagc                                                    18

<210>  12610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12610
ggtaagttct gtccaagc                                                    18

<210>  12611
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12611
gtaagttctg tccaagcc                                                    18

<210>  12612
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12612
gtaagttctg tccaagcc                                                    18

<210>  12613
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12613
gtaagttctg tccaagcc                                                    18

<210>  12614
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12614
gtaagttctg tccaagcc                                                    18

<210>  12615
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12615
gtaagttctg tccaagcc                                                    18

<210>  12616
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12616
gtaagttctg tccaagcc                                                    18

<210>  12617
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12617
agtcggtaag ttctgtcc                                                    18

<210>  12618
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12618
agtcggtaag ttctgtcc                                                    18

<210>  12619
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12619
agtcggtaag ttctgtcc                                                    18

<210>  12620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12620
agtcggtaag ttctgtcc                                                    18

<210>  12621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12621
agtcggtaag ttctgtcc                                                    18

<210>  12622
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12622
agtcggtaag ttctgtcc                                                    18

<210>  12623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12623
agtcggtaag ttctgtcc                                                    18

<210>  12624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12624
ctgtccaagc ccggttga                                                    18

<210>  12625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12625
ctgtccaagc ccggttga                                                    18

<210>  12626
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12626
ctgtccaagc ccggttga                                                    18

<210>  12627
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12627
ctgtccaagc ccggttga                                                    18

<210>  12628
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12628
ctgtccaagc ccggttga                                                    18

<210>  12629
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12629
ctgtccaagc ccggttga                                                    18

<210>  12630
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12630
ctgtccaagc ccggttga                                                    18

<210>  12631
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12631
ctgtccaagc ccggttga                                                    18

<210>  12632
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12632
ctgtccaagc ccggttga                                                    18

<210>  12633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12633
ggtaagttct gtccaagc                                                    18

<210>  12634
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12634
ggtaagttct gtccaagc                                                    18

<210>  12635
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12635
ggtaagttct gtccaagc                                                    18

<210>  12636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12636
ggtaagttct gtccaagc                                                    18

<210>  12637
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12637
ggtaagttct gtccaagc                                                    18

<210>  12638
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12638
ggtaagttct gtccaagc                                                    18

<210>  12639
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12639
ggtaagttct gtccaagc                                                    18

<210>  12640
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12640
ggtaagttct gtccaagc                                                    18

<210>  12641
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12641
ggtaagttct gtccaagc                                                    18

<210>  12642
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12642
ggtaagttct gtccaagc                                                    18

<210>  12643
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12643
ggtaagttct gtccaagc                                                    18

<210>  12644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12644
ggtaagttct gtccaagc                                                    18

<210>  12645
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12645
ggtaagttct gtccaagc                                                    18

<210>  12646
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12646
ggtaagttct gtccaagc                                                    18

<210>  12647
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12647
ggtaagttct gtccaagc                                                    18

<210>  12648
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12648
gtaagttctg tccaagcc                                                    18

<210>  12649
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12649
gtaagttctg tccaagcc                                                    18

<210>  12650
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12650
gtaagttctg tccaagcc                                                    18

<210>  12651
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12651
gtaagttctg tccaagcc                                                    18

<210>  12652
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12652
gtaagttctg tccaagcc                                                    18

<210>  12653
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12653
gtaagttctg tccaagcc                                                    18

<210>  12654
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12654
gtaagttctg tccaagcc                                                    18

<210>  12655
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12655
gtaagttctg tccaagcc                                                    18

<210>  12656
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12656
gtaagttctg tccaagcc                                                    18

<210>  12657
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12657
gtaagttctg tccaagcc                                                    18

<210>  12658
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12658
gtaagttctg tccaagcc                                                    18

<210>  12659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12659
gtaagttctg tccaagcc                                                    18

<210>  12660
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12660
gtaagttctg tccaagcc                                                    18

<210>  12661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12661
gtaagttctg tccaagcc                                                    18

<210>  12662
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12662
gtaagttctg tccaagcc                                                    18

<210>  12663
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12663
agtcggtaag ttctgtcc                                                    18

<210>  12664
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12664
agtcggtaag ttctgtcc                                                    18

<210>  12665
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12665
agtcggtaag ttctgtcc                                                    18

<210>  12666
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12666
agtcggtaag ttctgtcc                                                    18

<210>  12667
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12667
agtcggtaag ttctgtcc                                                    18

<210>  12668
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12668
agtcggtaag ttctgtcc                                                    18

<210>  12669
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12669
agtcggtaag ttctgtcc                                                    18

<210>  12670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12670
agtcggtaag ttctgtcc                                                    18

<210>  12671
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12671
agtcggtaag ttctgtcc                                                    18

<210>  12672
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12672
agtcggtaag ttctgtcc                                                    18

<210>  12673
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12673
agtcggtaag ttctgtcc                                                    18

<210>  12674
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12674
agtcggtaag ttctgtcc                                                    18

<210>  12675
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12675
agtcggtaag ttctgtcc                                                    18

<210>  12676
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12676
agtcggtaag ttctgtcc                                                    18

<210>  12677
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12677
agtcggtaag ttctgtcc                                                    18

<210>  12678
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12678
agtcggtaag ttctgtcc                                                    18

<210>  12679
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12679
agtcggtaag ttctgtcc                                                    18

<210>  12680
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12680
agtcggtaag ttctgtcc                                                    18

<210>  12681
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12681
agtcggtaag ttctgtcc                                                    18

<210>  12682
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12682
agtcggtaag ttctgtcc                                                    18

<210>  12683
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12683
agtcggtaag ttctgtcc                                                    18

<210>  12684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12684
ctgtccaagc ccggttga                                                    18

<210>  12685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12685
ctgtccaagc ccggttga                                                    18

<210>  12686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12686
ctgtccaagc ccggttga                                                    18

<210>  12687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12687
ctgtccaagc ccggttga                                                    18

<210>  12688
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12688
ctgtccaagc ccggttga                                                    18

<210>  12689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12689
ctgtccaagc ccggttga                                                    18

<210>  12690
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12690
ctgtccaagc ccggttga                                                    18

<210>  12691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12691
ctgtccaagc ccggttga                                                    18

<210>  12692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12692
ctgtccaagc ccggttga                                                    18

<210>  12693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12693
ctgtccaagc ccggttga                                                    18

<210>  12694
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12694
ctgtccaagc ccggttga                                                    18

<210>  12695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12695
ctgtccaagc ccggttga                                                    18

<210>  12696
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12696
ctgtccaagc ccggttga                                                    18

<210>  12697
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12697
ctgtccaagc ccggttga                                                    18

<210>  12698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12698
ctgtccaagc ccggttga                                                    18

<210>  12699
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12699
ctgtccaagc ccggttga                                                    18

<210>  12700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12700
ctgtccaagc ccggttga                                                    18

<210>  12701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12701
ctgtccaagc ccggttga                                                    18

<210>  12702
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12702
ctgtccaagc ccggttga                                                    18

<210>  12703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12703
ctgtccaagc ccggttga                                                    18

<210>  12704
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12704
ctgtccaagc ccggttga                                                    18

<210>  12705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12705
ctgtccaagc ccggttga                                                    18

<210>  12706
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12706
ctgtccaagc ccggttga                                                    18

<210>  12707
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12707
ctgtccaagc ccggttga                                                    18

<210>  12708
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12708
ctgtccaagc ccggttga                                                    18

<210>  12709
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12709
ctgtccaagc ccggttga                                                    18

<210>  12710
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12710
ctgtccaagc ccggttga                                                    18

<210>  12711
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12711
ctgtccaagc ccggttga                                                    18

<210>  12712
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12712
ctgtccaagc ccggttga                                                    18

<210>  12713
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12713
ctgtccaagc ccggttga                                                    18

<210>  12714
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12714
ctgtccaagc ccggttga                                                    18

<210>  12715
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12715
ctgtccaagc ccggttga                                                    18

<210>  12716
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12716
ctgtccaagc ccggttga                                                    18

<210>  12717
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12717
ctgtccaagc ccggttga                                                    18

<210>  12718
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12718
ctgtccaagc ccggttga                                                    18

<210>  12719
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12719
ctgtccaagc ccggttga                                                    18

<210>  12720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12720
tcaaggaaga tggcatttct                                                  20

<210>  12721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12721
tcaaggaaga tggcatttct                                                  20

<210>  12722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12722
tcaaggaaga tggcatttct                                                  20

<210>  12723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12723
tcaaggaaga tggcatttct                                                  20

<210>  12724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12724
tcaaggaaga tggcatttct                                                  20

<210>  12725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12725
tcaaggaaga tggcatttct                                                  20

<210>  12726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12726
tcaaggaaga tggcatttct                                                  20

<210>  12727
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12727
tcaaggaaga tggcatttct ag                                               22

<210>  12728
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12728
tcaaggaaga tggcatttct ag                                               22

<210>  12729
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12729
tcaaggaaga tggcatttct ag                                               22

<210>  12730
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12730
tcaaggaaga tggcatttct ag                                               22

<210>  12731
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12731
tcaaggaaga tggcatttct ag                                               22

<210>  12732
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12732
tcaaggaaga tggcatttct ag                                               22

<210>  12733
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12733
tcaaggaaga tggcatttct ag                                               22

<210>  12734
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12734
tcaaggaaga tggcatttct ag                                               22

<210>  12735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12735
tcaaggaaga tggcatttct                                                  20

<210>  12736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12736
tcaaggaaga tggcatttct                                                  20

<210>  12737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12737
tcaaggaaga tggcatttct                                                  20

<210>  12738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12738
tcaaggaaga tggcatttct                                                  20

<210>  12739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12739
tcaaggaaga tggcatttct                                                  20

<210>  12740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12740
tcaaggaaga tggcatttct                                                  20

<210>  12741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12741
tcaaggaaga tggcatttct                                                  20

<210>  12742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12742
tcaaggaaga tggcatttct                                                  20

<210>  12743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12743
tcaaggaaga tggcatttct                                                  20

<210>  12744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12744
tcaaggaaga tggcatttct                                                  20

<210>  12745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12745
tcaaggaaga tggcatttct                                                  20

<210>  12746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12746
tcaaggaaga tggcatttct                                                  20

<210>  12747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12747
tcaaggaaga tggcatttct                                                  20

<210>  12748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12748
tcaaggaaga tggcatttct                                                  20

<210>  12749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12749
tcaaggaaga tggcatttct                                                  20

<210>  12750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12750
tcaaggaaga tggcatttct                                                  20

<210>  12751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12751
tcaaggaaga tggcatttct                                                  20

<210>  12752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12752
tcaaggaaga tggcatttct                                                  20

<210>  12753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12753
tcaaggaaga tggcatttct                                                  20

<210>  12754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12754
tcaaggaaga tggcatttct                                                  20

<210>  12755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12755
tcaaggaaga tggcatttct                                                  20

<210>  12756
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12756
tcaaggaaga tggcatttct ag                                               22

<210>  12757
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12757
tcaaggaaga tggcatttct ag                                               22

<210>  12758
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12758
tcaaggaaga tggcatttct ag                                               22

<210>  12759
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12759
tcaaggaaga tggcatttct ag                                               22

<210>  12760
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12760
tcaaggaaga tggcatttct ag                                               22

<210>  12761
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12761
tcaaggaaga tggcatttct ag                                               22

<210>  12762
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12762
tcaaggaaga tggcatttct ag                                               22

<210>  12763
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12763
tcaaggaaga tggcatttct ag                                               22

<210>  12764
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12764
tcaaggaaga tggcatttct ag                                               22

<210>  12765
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12765
tcaaggaaga tggcatttct ag                                               22

<210>  12766
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12766
tcaaggaaga tggcatttct ag                                               22

<210>  12767
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12767
tcaaggaaga tggcatttct ag                                               22

<210>  12768
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12768
tcaaggaaga tggcatttct ag                                               22

<210>  12769
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12769
tcaaggaaga tggcatttct ag                                               22

<210>  12770
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12770
tcaaggaaga tggcatttct ag                                               22

<210>  12771
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12771
tcaaggaaga tggcatttct ag                                               22

<210>  12772
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12772
tcaaggaaga tggcatttct ag                                               22

<210>  12773
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12773
tcaaggaaga tggcatttct ag                                               22

<210>  12774
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12774
tcaaggaaga tggcatttct ag                                               22

<210>  12775
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12775
tcaaggaaga tggcatttct ag                                               22

<210>  12776
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12776
tcaaggaaga tggcatttct ag                                               22

<210>  12777
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12777
tcaaggaaga tggcatttct ag                                               22

<210>  12778
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12778
tcaaggaaga tggcatttct ag                                               22

<210>  12779
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12779
tcaaggaaga tggcatttct ag                                               22

<210>  12780
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12780
tcaaggaaga tggcatttct ag                                               22

<210>  12781
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12781
tcaaggaaga tggcatttct ag                                               22

<210>  12782
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12782
tcaaggaaga tggcatttct ag                                               22

<210>  12783
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12783
tcaaggaaga tggcatttct ag                                               22

<210>  12784
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12784
ggtaagttct gtccaagc                                                    18

<210>  12785
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12785
ggtaagttct gtccaagc                                                    18

<210>  12786
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12786
ggtaagttct gtccaagc                                                    18

<210>  12787
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12787
ggtaagttct gtccaagc                                                    18

<210>  12788
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12788
ggtaagttct gtccaagc                                                    18

<210>  12789
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12789
ggtaagttct gtccaagc                                                    18

<210>  12790
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12790
gtaagttctg tccaagcc                                                    18

<210>  12791
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12791
gtaagttctg tccaagcc                                                    18

<210>  12792
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12792
gtaagttctg tccaagcc                                                    18

<210>  12793
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12793
gtaagttctg tccaagcc                                                    18

<210>  12794
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12794
gtaagttctg tccaagcc                                                    18

<210>  12795
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12795
gtaagttctg tccaagcc                                                    18

<210>  12796
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12796
agtcggtaag ttctgtcc                                                    18

<210>  12797
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12797
agtcggtaag ttctgtcc                                                    18

<210>  12798
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12798
agtcggtaag ttctgtcc                                                    18

<210>  12799
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12799
agtcggtaag ttctgtcc                                                    18

<210>  12800
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12800
agtcggtaag ttctgtcc                                                    18

<210>  12801
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12801
agtcggtaag ttctgtcc                                                    18

<210>  12802
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12802
agtcggtaag ttctgtcc                                                    18

<210>  12803
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12803
ctgtccaagc ccggttga                                                    18

<210>  12804
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12804
ctgtccaagc ccggttga                                                    18

<210>  12805
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12805
ctgtccaagc ccggttga                                                    18

<210>  12806
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12806
ctgtccaagc ccggttga                                                    18

<210>  12807
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12807
ctgtccaagc ccggttga                                                    18

<210>  12808
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12808
ctgtccaagc ccggttga                                                    18

<210>  12809
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12809
ctgtccaagc ccggttga                                                    18

<210>  12810
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12810
ctgtccaagc ccggttga                                                    18

<210>  12811
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12811
ctgtccaagc ccggttga                                                    18

<210>  12812
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12812
ggtaagttct gtccaagc                                                    18

<210>  12813
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12813
ggtaagttct gtccaagc                                                    18

<210>  12814
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12814
ggtaagttct gtccaagc                                                    18

<210>  12815
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12815
ggtaagttct gtccaagc                                                    18

<210>  12816
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12816
ggtaagttct gtccaagc                                                    18

<210>  12817
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12817
ggtaagttct gtccaagc                                                    18

<210>  12818
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12818
ggtaagttct gtccaagc                                                    18

<210>  12819
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12819
ggtaagttct gtccaagc                                                    18

<210>  12820
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12820
ggtaagttct gtccaagc                                                    18

<210>  12821
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12821
ggtaagttct gtccaagc                                                    18

<210>  12822
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12822
ggtaagttct gtccaagc                                                    18

<210>  12823
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12823
ggtaagttct gtccaagc                                                    18

<210>  12824
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12824
ggtaagttct gtccaagc                                                    18

<210>  12825
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12825
ggtaagttct gtccaagc                                                    18

<210>  12826
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  12826
ggtaagttct gtccaagc                                                    18

<210>  12827
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12827
gtaagttctg tccaagcc                                                    18

<210>  12828
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12828
gtaagttctg tccaagcc                                                    18

<210>  12829
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12829
gtaagttctg tccaagcc                                                    18

<210>  12830
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12830
gtaagttctg tccaagcc                                                    18

<210>  12831
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12831
gtaagttctg tccaagcc                                                    18

<210>  12832
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12832
gtaagttctg tccaagcc                                                    18

<210>  12833
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12833
gtaagttctg tccaagcc                                                    18

<210>  12834
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12834
gtaagttctg tccaagcc                                                    18

<210>  12835
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12835
gtaagttctg tccaagcc                                                    18

<210>  12836
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12836
gtaagttctg tccaagcc                                                    18

<210>  12837
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12837
gtaagttctg tccaagcc                                                    18

<210>  12838
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12838
gtaagttctg tccaagcc                                                    18

<210>  12839
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12839
gtaagttctg tccaagcc                                                    18

<210>  12840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12840
gtaagttctg tccaagcc                                                    18

<210>  12841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12841
gtaagttctg tccaagcc                                                    18

<210>  12842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12842
agtcggtaag ttctgtcc                                                    18

<210>  12843
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12843
agtcggtaag ttctgtcc                                                    18

<210>  12844
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12844
agtcggtaag ttctgtcc                                                    18

<210>  12845
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12845
agtcggtaag ttctgtcc                                                    18

<210>  12846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12846
agtcggtaag ttctgtcc                                                    18

<210>  12847
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12847
agtcggtaag ttctgtcc                                                    18

<210>  12848
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12848
agtcggtaag ttctgtcc                                                    18

<210>  12849
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12849
agtcggtaag ttctgtcc                                                    18

<210>  12850
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12850
agtcggtaag ttctgtcc                                                    18

<210>  12851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12851
agtcggtaag ttctgtcc                                                    18

<210>  12852
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12852
agtcggtaag ttctgtcc                                                    18

<210>  12853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12853
agtcggtaag ttctgtcc                                                    18

<210>  12854
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12854
agtcggtaag ttctgtcc                                                    18

<210>  12855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12855
agtcggtaag ttctgtcc                                                    18

<210>  12856
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12856
agtcggtaag ttctgtcc                                                    18

<210>  12857
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12857
agtcggtaag ttctgtcc                                                    18

<210>  12858
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12858
agtcggtaag ttctgtcc                                                    18

<210>  12859
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  12859
agtcggtaag ttctgtcc                                                    18

<210>  12860
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12860
agtcggtaag ttctgtcc                                                    18

<210>  12861
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12861
agtcggtaag ttctgtcc                                                    18

<210>  12862
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12862
agtcggtaag ttctgtcc                                                    18

<210>  12863
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12863
ctgtccaagc ccggttga                                                    18

<210>  12864
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12864
ctgtccaagc ccggttga                                                    18

<210>  12865
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12865
ctgtccaagc ccggttga                                                    18

<210>  12866
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12866
ctgtccaagc ccggttga                                                    18

<210>  12867
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12867
ctgtccaagc ccggttga                                                    18

<210>  12868
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12868
ctgtccaagc ccggttga                                                    18

<210>  12869
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12869
ctgtccaagc ccggttga                                                    18

<210>  12870
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12870
ctgtccaagc ccggttga                                                    18

<210>  12871
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12871
ctgtccaagc ccggttga                                                    18

<210>  12872
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12872
ctgtccaagc ccggttga                                                    18

<210>  12873
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12873
ctgtccaagc ccggttga                                                    18

<210>  12874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12874
ctgtccaagc ccggttga                                                    18

<210>  12875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12875
ctgtccaagc ccggttga                                                    18

<210>  12876
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12876
ctgtccaagc ccggttga                                                    18

<210>  12877
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12877
ctgtccaagc ccggttga                                                    18

<210>  12878
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12878
ctgtccaagc ccggttga                                                    18

<210>  12879
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12879
ctgtccaagc ccggttga                                                    18

<210>  12880
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12880
ctgtccaagc ccggttga                                                    18

<210>  12881
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12881
ctgtccaagc ccggttga                                                    18

<210>  12882
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12882
ctgtccaagc ccggttga                                                    18

<210>  12883
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12883
ctgtccaagc ccggttga                                                    18

<210>  12884
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12884
ctgtccaagc ccggttga                                                    18

<210>  12885
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12885
ctgtccaagc ccggttga                                                    18

<210>  12886
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12886
ctgtccaagc ccggttga                                                    18

<210>  12887
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12887
ctgtccaagc ccggttga                                                    18

<210>  12888
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12888
ctgtccaagc ccggttga                                                    18

<210>  12889
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12889
ctgtccaagc ccggttga                                                    18

<210>  12890
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12890
ctgtccaagc ccggttga                                                    18

<210>  12891
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12891
ctgtccaagc ccggttga                                                    18

<210>  12892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12892
ctgtccaagc ccggttga                                                    18

<210>  12893
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12893
ctgtccaagc ccggttga                                                    18

<210>  12894
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12894
ctgtccaagc ccggttga                                                    18

<210>  12895
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12895
ctgtccaagc ccggttga                                                    18

<210>  12896
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12896
ctgtccaagc ccggttga                                                    18

<210>  12897
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12897
ctgtccaagc ccggttga                                                    18

<210>  12898
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12898
ctgtccaagc ccggttga                                                    18

<210>  12899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12899
tcaaggaaga tggcatttct                                                  20

<210>  12900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12900
tcaaggaaga tggcatttct                                                  20

<210>  12901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12901
tcaaggaaga tggcatttct                                                  20

<210>  12902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12902
tcaaggaaga tggcatttct                                                  20

<210>  12903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12903
tcaaggaaga tggcatttct                                                  20

<210>  12904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12904
tcaaggaaga tggcatttct                                                  20

<210>  12905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12905
tcaaggaaga tggcatttct                                                  20

<210>  12906
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12906
tcaaggaaga tggcatttct ag                                               22

<210>  12907
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12907
tcaaggaaga tggcatttct ag                                               22

<210>  12908
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12908
tcaaggaaga tggcatttct ag                                               22

<210>  12909
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12909
tcaaggaaga tggcatttct ag                                               22

<210>  12910
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12910
tcaaggaaga tggcatttct ag                                               22

<210>  12911
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12911
tcaaggaaga tggcatttct ag                                               22

<210>  12912
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12912
tcaaggaaga tggcatttct ag                                               22

<210>  12913
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12913
tcaaggaaga tggcatttct ag                                               22

<210>  12914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12914
tcaaggaaga tggcatttct                                                  20

<210>  12915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12915
tcaaggaaga tggcatttct                                                  20

<210>  12916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12916
tcaaggaaga tggcatttct                                                  20

<210>  12917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12917
tcaaggaaga tggcatttct                                                  20

<210>  12918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12918
tcaaggaaga tggcatttct                                                  20

<210>  12919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12919
tcaaggaaga tggcatttct                                                  20

<210>  12920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12920
tcaaggaaga tggcatttct                                                  20

<210>  12921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12921
tcaaggaaga tggcatttct                                                  20

<210>  12922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12922
tcaaggaaga tggcatttct                                                  20

<210>  12923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12923
tcaaggaaga tggcatttct                                                  20

<210>  12924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12924
tcaaggaaga tggcatttct                                                  20

<210>  12925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12925
tcaaggaaga tggcatttct                                                  20

<210>  12926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12926
tcaaggaaga tggcatttct                                                  20

<210>  12927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12927
tcaaggaaga tggcatttct                                                  20

<210>  12928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12928
tcaaggaaga tggcatttct                                                  20

<210>  12929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12929
tcaaggaaga tggcatttct                                                  20

<210>  12930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12930
tcaaggaaga tggcatttct                                                  20

<210>  12931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12931
tcaaggaaga tggcatttct                                                  20

<210>  12932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12932
tcaaggaaga tggcatttct                                                  20

<210>  12933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12933
tcaaggaaga tggcatttct                                                  20

<210>  12934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  12934
tcaaggaaga tggcatttct                                                  20

<210>  12935
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12935
tcaaggaaga tggcatttct ag                                               22

<210>  12936
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12936
tcaaggaaga tggcatttct ag                                               22

<210>  12937
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12937
tcaaggaaga tggcatttct ag                                               22

<210>  12938
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12938
tcaaggaaga tggcatttct ag                                               22

<210>  12939
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12939
tcaaggaaga tggcatttct ag                                               22

<210>  12940
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12940
tcaaggaaga tggcatttct ag                                               22

<210>  12941
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12941
tcaaggaaga tggcatttct ag                                               22

<210>  12942
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12942
tcaaggaaga tggcatttct ag                                               22

<210>  12943
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12943
tcaaggaaga tggcatttct ag                                               22

<210>  12944
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12944
tcaaggaaga tggcatttct ag                                               22

<210>  12945
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12945
tcaaggaaga tggcatttct ag                                               22

<210>  12946
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12946
tcaaggaaga tggcatttct ag                                               22

<210>  12947
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12947
tcaaggaaga tggcatttct ag                                               22

<210>  12948
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12948
tcaaggaaga tggcatttct ag                                               22

<210>  12949
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12949
tcaaggaaga tggcatttct ag                                               22

<210>  12950
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12950
tcaaggaaga tggcatttct ag                                               22

<210>  12951
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12951
tcaaggaaga tggcatttct ag                                               22

<210>  12952
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12952
tcaaggaaga tggcatttct ag                                               22

<210>  12953
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12953
tcaaggaaga tggcatttct ag                                               22

<210>  12954
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12954
tcaaggaaga tggcatttct ag                                               22

<210>  12955
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12955
tcaaggaaga tggcatttct ag                                               22

<210>  12956
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12956
tcaaggaaga tggcatttct ag                                               22

<210>  12957
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12957
tcaaggaaga tggcatttct ag                                               22

<210>  12958
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12958
tcaaggaaga tggcatttct ag                                               22

<210>  12959
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12959
tcaaggaaga tggcatttct ag                                               22

<210>  12960
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12960
tcaaggaaga tggcatttct ag                                               22

<210>  12961
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12961
tcaaggaaga tggcatttct ag                                               22

<210>  12962
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  12962
tcaaggaaga tggcatttct ag                                               22

<210>  12963
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12963
gguaaguucu guccaagc                                                    18

<210>  12964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12964
gguaaguucu guccaagc                                                    18

<210>  12965
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12965
gguaaguucu guccaagc                                                    18

<210>  12966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12966
gguaaguucu guccaagc                                                    18

<210>  12967
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12967
gguaaguucu guccaagc                                                    18

<210>  12968
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12968
gguaaguucu guccaagc                                                    18

<210>  12969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12969
gguaaguucu guccaagc                                                    18

<210>  12970
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12970
guaaguucug uccaagcc                                                    18

<210>  12971
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12971
guaaguucug uccaagcc                                                    18

<210>  12972
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12972
guaaguucug uccaagcc                                                    18

<210>  12973
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12973
guaaguucug uccaagcc                                                    18

<210>  12974
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12974
guaaguucug uccaagcc                                                    18

<210>  12975
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12975
guaaguucug uccaagcc                                                    18

<210>  12976
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12976
guaaguucug uccaagcc                                                    18

<210>  12977
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12977
agucgguaag uucugucc                                                    18

<210>  12978
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12978
agucgguaag uucugucc                                                    18

<210>  12979
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12979
agucgguaag uucugucc                                                    18

<210>  12980
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12980
agucgguaag uucugucc                                                    18

<210>  12981
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12981
agucgguaag uucugucc                                                    18

<210>  12982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12982
agucgguaag uucugucc                                                    18

<210>  12983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12983
agucgguaag uucugucc                                                    18

<210>  12984
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12984
agucgguaag uucugucc                                                    18

<210>  12985
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12985
cuguccaagc ccgguuga                                                    18

<210>  12986
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12986
cuguccaagc ccgguuga                                                    18

<210>  12987
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12987
cuguccaagc ccgguuga                                                    18

<210>  12988
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12988
cuguccaagc ccgguuga                                                    18

<210>  12989
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12989
cuguccaagc ccgguuga                                                    18

<210>  12990
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12990
cuguccaagc ccgguuga                                                    18

<210>  12991
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12991
cuguccaagc ccgguuga                                                    18

<210>  12992
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12992
cuguccaagc ccgguuga                                                    18

<210>  12993
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12993
cuguccaagc ccgguuga                                                    18

<210>  12994
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12994
cuguccaagc ccgguuga                                                    18

<210>  12995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12995
gguaaguucu guccaagc                                                    18

<210>  12996
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12996
gguaaguucu guccaagc                                                    18

<210>  12997
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12997
gguaaguucu guccaagc                                                    18

<210>  12998
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12998
gguaaguucu guccaagc                                                    18

<210>  12999
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  12999
gguaaguucu guccaagc                                                    18

<210>  13000
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13000
gguaaguucu guccaagc                                                    18

<210>  13001
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13001
gguaaguucu guccaagc                                                    18

<210>  13002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13002
gguaaguucu guccaagc                                                    18

<210>  13003
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13003
gguaaguucu guccaagc                                                    18

<210>  13004
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13004
gguaaguucu guccaagc                                                    18

<210>  13005
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13005
gguaaguucu guccaagc                                                    18

<210>  13006
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13006
gguaaguucu guccaagc                                                    18

<210>  13007
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13007
gguaaguucu guccaagc                                                    18

<210>  13008
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13008
gguaaguucu guccaagc                                                    18

<210>  13009
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13009
gguaaguucu guccaagc                                                    18

<210>  13010
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13010
gguaaguucu guccaagc                                                    18

<210>  13011
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13011
gguaaguucu guccaagc                                                    18

<210>  13012
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13012
gguaaguucu guccaagc                                                    18

<210>  13013
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13013
gguaaguucu guccaagc                                                    18

<210>  13014
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13014
gguaaguucu guccaagc                                                    18

<210>  13015
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13015
gguaaguucu guccaagc                                                    18

<210>  13016
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13016
guaaguucug uccaagcc                                                    18

<210>  13017
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13017
guaaguucug uccaagcc                                                    18

<210>  13018
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13018
guaaguucug uccaagcc                                                    18

<210>  13019
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13019
guaaguucug uccaagcc                                                    18

<210>  13020
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13020
guaaguucug uccaagcc                                                    18

<210>  13021
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13021
guaaguucug uccaagcc                                                    18

<210>  13022
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13022
guaaguucug uccaagcc                                                    18

<210>  13023
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13023
guaaguucug uccaagcc                                                    18

<210>  13024
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13024
guaaguucug uccaagcc                                                    18

<210>  13025
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13025
guaaguucug uccaagcc                                                    18

<210>  13026
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13026
guaaguucug uccaagcc                                                    18

<210>  13027
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13027
guaaguucug uccaagcc                                                    18

<210>  13028
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13028
guaaguucug uccaagcc                                                    18

<210>  13029
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13029
guaaguucug uccaagcc                                                    18

<210>  13030
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13030
guaaguucug uccaagcc                                                    18

<210>  13031
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13031
guaaguucug uccaagcc                                                    18

<210>  13032
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13032
guaaguucug uccaagcc                                                    18

<210>  13033
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13033
guaaguucug uccaagcc                                                    18

<210>  13034
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13034
guaaguucug uccaagcc                                                    18

<210>  13035
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13035
guaaguucug uccaagcc                                                    18

<210>  13036
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13036
guaaguucug uccaagcc                                                    18

<210>  13037
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13037
agucgguaag uucugucc                                                    18

<210>  13038
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13038
agucgguaag uucugucc                                                    18

<210>  13039
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13039
agucgguaag uucugucc                                                    18

<210>  13040
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13040
agucgguaag uucugucc                                                    18

<210>  13041
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13041
agucgguaag uucugucc                                                    18

<210>  13042
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13042
agucgguaag uucugucc                                                    18

<210>  13043
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13043
agucgguaag uucugucc                                                    18

<210>  13044
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13044
agucgguaag uucugucc                                                    18

<210>  13045
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13045
agucgguaag uucugucc                                                    18

<210>  13046
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13046
agucgguaag uucugucc                                                    18

<210>  13047
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13047
agucgguaag uucugucc                                                    18

<210>  13048
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13048
agucgguaag uucugucc                                                    18

<210>  13049
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13049
agucgguaag uucugucc                                                    18

<210>  13050
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13050
agucgguaag uucugucc                                                    18

<210>  13051
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13051
agucgguaag uucugucc                                                    18

<210>  13052
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13052
agucgguaag uucugucc                                                    18

<210>  13053
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13053
agucgguaag uucugucc                                                    18

<210>  13054
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13054
agucgguaag uucugucc                                                    18

<210>  13055
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13055
agucgguaag uucugucc                                                    18

<210>  13056
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13056
agucgguaag uucugucc                                                    18

<210>  13057
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13057
agucgguaag uucugucc                                                    18

<210>  13058
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13058
agucgguaag uucugucc                                                    18

<210>  13059
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13059
agucgguaag uucugucc                                                    18

<210>  13060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13060
agucgguaag uucugucc                                                    18

<210>  13061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13061
agucgguaag uucugucc                                                    18

<210>  13062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13062
agucgguaag uucugucc                                                    18

<210>  13063
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13063
agucgguaag uucugucc                                                    18

<210>  13064
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13064
agucgguaag uucugucc                                                    18

<210>  13065
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13065
cuguccaagc ccgguuga                                                    18

<210>  13066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13066
cuguccaagc ccgguuga                                                    18

<210>  13067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13067
cuguccaagc ccgguuga                                                    18

<210>  13068
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13068
cuguccaagc ccgguuga                                                    18

<210>  13069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13069
cuguccaagc ccgguuga                                                    18

<210>  13070
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13070
cuguccaagc ccgguuga                                                    18

<210>  13071
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13071
cuguccaagc ccgguuga                                                    18

<210>  13072
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13072
cuguccaagc ccgguuga                                                    18

<210>  13073
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13073
cuguccaagc ccgguuga                                                    18

<210>  13074
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13074
cuguccaagc ccgguuga                                                    18

<210>  13075
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13075
cuguccaagc ccgguuga                                                    18

<210>  13076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13076
cuguccaagc ccgguuga                                                    18

<210>  13077
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13077
cuguccaagc ccgguuga                                                    18

<210>  13078
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13078
cuguccaagc ccgguuga                                                    18

<210>  13079
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13079
cuguccaagc ccgguuga                                                    18

<210>  13080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13080
cuguccaagc ccgguuga                                                    18

<210>  13081
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13081
cuguccaagc ccgguuga                                                    18

<210>  13082
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13082
cuguccaagc ccgguuga                                                    18

<210>  13083
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13083
cuguccaagc ccgguuga                                                    18

<210>  13084
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13084
cuguccaagc ccgguuga                                                    18

<210>  13085
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13085
cuguccaagc ccgguuga                                                    18

<210>  13086
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13086
cuguccaagc ccgguuga                                                    18

<210>  13087
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13087
cuguccaagc ccgguuga                                                    18

<210>  13088
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13088
cuguccaagc ccgguuga                                                    18

<210>  13089
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13089
cuguccaagc ccgguuga                                                    18

<210>  13090
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13090
cuguccaagc ccgguuga                                                    18

<210>  13091
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13091
cuguccaagc ccgguuga                                                    18

<210>  13092
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13092
cuguccaagc ccgguuga                                                    18

<210>  13093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13093
cuguccaagc ccgguuga                                                    18

<210>  13094
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13094
cuguccaagc ccgguuga                                                    18

<210>  13095
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13095
cuguccaagc ccgguuga                                                    18

<210>  13096
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13096
cuguccaagc ccgguuga                                                    18

<210>  13097
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13097
cuguccaagc ccgguuga                                                    18

<210>  13098
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13098
cuguccaagc ccgguuga                                                    18

<210>  13099
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13099
cuguccaagc ccgguuga                                                    18

<210>  13100
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13100
cuguccaagc ccgguuga                                                    18

<210>  13101
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13101
cuguccaagc ccgguuga                                                    18

<210>  13102
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13102
cuguccaagc ccgguuga                                                    18

<210>  13103
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13103
cuguccaagc ccgguuga                                                    18

<210>  13104
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13104
cuguccaagc ccgguuga                                                    18

<210>  13105
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13105
cuguccaagc ccgguuga                                                    18

<210>  13106
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13106
cuguccaagc ccgguuga                                                    18

<210>  13107
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13107
cuguccaagc ccgguuga                                                    18

<210>  13108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13108
cuguccaagc ccgguuga                                                    18

<210>  13109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13109
cuguccaagc ccgguuga                                                    18

<210>  13110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13110
tcaaggaaga uggcauuuct                                                  20

<210>  13111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13111
tcaaggaaga uggcauuuct                                                  20

<210>  13112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13112
tcaaggaaga uggcauuuct                                                  20

<210>  13113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13113
tcaaggaaga uggcauuuct                                                  20

<210>  13114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13114
tcaaggaaga uggcauuuct                                                  20

<210>  13115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13115
tcaaggaaga uggcauuuct                                                  20

<210>  13116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13116
tcaaggaaga uggcauuuct                                                  20

<210>  13117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13117
tcaaggaaga uggcauuuct                                                  20

<210>  13118
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13118
tcaaggaaga uggcauuucu ag                                               22

<210>  13119
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13119
tcaaggaaga uggcauuucu ag                                               22

<210>  13120
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13120
tcaaggaaga uggcauuucu ag                                               22

<210>  13121
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13121
tcaaggaaga uggcauuucu ag                                               22

<210>  13122
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13122
tcaaggaaga uggcauuucu ag                                               22

<210>  13123
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13123
tcaaggaaga uggcauuucu ag                                               22

<210>  13124
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13124
tcaaggaaga uggcauuucu ag                                               22

<210>  13125
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13125
tcaaggaaga uggcauuucu ag                                               22

<210>  13126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13126
tcaaggaaga uggcauuuct                                                  20

<210>  13127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13127
tcaaggaaga uggcauuuct                                                  20

<210>  13128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13128
tcaaggaaga uggcauuuct                                                  20

<210>  13129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13129
tcaaggaaga uggcauuuct                                                  20

<210>  13130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13130
tcaaggaaga uggcauuuct                                                  20

<210>  13131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13131
tcaaggaaga uggcauuuct                                                  20

<210>  13132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13132
tcaaggaaga uggcauuuct                                                  20

<210>  13133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13133
tcaaggaaga uggcauuuct                                                  20

<210>  13134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13134
tcaaggaaga uggcauuuct                                                  20

<210>  13135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13135
tcaaggaaga uggcauuuct                                                  20

<210>  13136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13136
tcaaggaaga uggcauuuct                                                  20

<210>  13137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13137
tcaaggaaga uggcauuuct                                                  20

<210>  13138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13138
tcaaggaaga uggcauuuct                                                  20

<210>  13139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13139
tcaaggaaga uggcauuuct                                                  20

<210>  13140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13140
tcaaggaaga uggcauuuct                                                  20

<210>  13141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13141
tcaaggaaga uggcauuuct                                                  20

<210>  13142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13142
tcaaggaaga uggcauuuct                                                  20

<210>  13143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13143
tcaaggaaga uggcauuuct                                                  20

<210>  13144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13144
tcaaggaaga uggcauuuct                                                  20

<210>  13145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13145
tcaaggaaga uggcauuuct                                                  20

<210>  13146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13146
tcaaggaaga uggcauuuct                                                  20

<210>  13147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13147
tcaaggaaga uggcauuuct                                                  20

<210>  13148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13148
tcaaggaaga uggcauuuct                                                  20

<210>  13149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13149
tcaaggaaga uggcauuuct                                                  20

<210>  13150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13150
tcaaggaaga uggcauuuct                                                  20

<210>  13151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13151
tcaaggaaga uggcauuuct                                                  20

<210>  13152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13152
tcaaggaaga uggcauuuct                                                  20

<210>  13153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13153
tcaaggaaga uggcauuuct                                                  20

<210>  13154
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13154
tcaaggaaga uggcauuucu ag                                               22

<210>  13155
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13155
tcaaggaaga uggcauuucu ag                                               22

<210>  13156
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13156
tcaaggaaga uggcauuucu ag                                               22

<210>  13157
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13157
tcaaggaaga uggcauuucu ag                                               22

<210>  13158
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13158
tcaaggaaga uggcauuucu ag                                               22

<210>  13159
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13159
tcaaggaaga uggcauuucu ag                                               22

<210>  13160
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13160
tcaaggaaga uggcauuucu ag                                               22

<210>  13161
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13161
tcaaggaaga uggcauuucu ag                                               22

<210>  13162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13162
tcaaggaaga uggcauuucu ag                                               22

<210>  13163
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13163
tcaaggaaga uggcauuucu ag                                               22

<210>  13164
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13164
tcaaggaaga uggcauuucu ag                                               22

<210>  13165
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13165
tcaaggaaga uggcauuucu ag                                               22

<210>  13166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13166
tcaaggaaga uggcauuucu ag                                               22

<210>  13167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13167
tcaaggaaga uggcauuucu ag                                               22

<210>  13168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13168
tcaaggaaga uggcauuucu ag                                               22

<210>  13169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13169
tcaaggaaga uggcauuucu ag                                               22

<210>  13170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13170
tcaaggaaga uggcauuucu ag                                               22

<210>  13171
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13171
tcaaggaaga uggcauuucu ag                                               22

<210>  13172
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13172
tcaaggaaga uggcauuucu ag                                               22

<210>  13173
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13173
tcaaggaaga uggcauuucu ag                                               22

<210>  13174
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13174
tcaaggaaga uggcauuucu ag                                               22

<210>  13175
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13175
tcaaggaaga uggcauuucu ag                                               22

<210>  13176
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13176
tcaaggaaga uggcauuucu ag                                               22

<210>  13177
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13177
tcaaggaaga uggcauuucu ag                                               22

<210>  13178
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13178
tcaaggaaga uggcauuucu ag                                               22

<210>  13179
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13179
tcaaggaaga uggcauuucu ag                                               22

<210>  13180
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13180
tcaaggaaga uggcauuucu ag                                               22

<210>  13181
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13181
tcaaggaaga uggcauuucu ag                                               22

<210>  13182
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13182
gguaaguucu guccaagc                                                    18

<210>  13183
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13183
gguaaguucu guccaagc                                                    18

<210>  13184
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13184
gguaaguucu guccaagc                                                    18

<210>  13185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13185
gguaaguucu guccaagc                                                    18

<210>  13186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13186
gguaaguucu guccaagc                                                    18

<210>  13187
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13187
gguaaguucu guccaagc                                                    18

<210>  13188
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13188
gguaaguucu guccaagc                                                    18

<210>  13189
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13189
guaaguucug uccaagcc                                                    18

<210>  13190
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13190
guaaguucug uccaagcc                                                    18

<210>  13191
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13191
guaaguucug uccaagcc                                                    18

<210>  13192
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13192
guaaguucug uccaagcc                                                    18

<210>  13193
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13193
guaaguucug uccaagcc                                                    18

<210>  13194
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13194
guaaguucug uccaagcc                                                    18

<210>  13195
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13195
guaaguucug uccaagcc                                                    18

<210>  13196
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13196
agucgguaag uucugucc                                                    18

<210>  13197
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13197
agucgguaag uucugucc                                                    18

<210>  13198
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13198
agucgguaag uucugucc                                                    18

<210>  13199
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13199
agucgguaag uucugucc                                                    18

<210>  13200
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13200
agucgguaag uucugucc                                                    18

<210>  13201
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13201
agucgguaag uucugucc                                                    18

<210>  13202
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13202
agucgguaag uucugucc                                                    18

<210>  13203
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13203
agucgguaag uucugucc                                                    18

<210>  13204
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13204
cuguccaagc ccgguuga                                                    18

<210>  13205
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13205
cuguccaagc ccgguuga                                                    18

<210>  13206
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13206
cuguccaagc ccgguuga                                                    18

<210>  13207
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13207
cuguccaagc ccgguuga                                                    18

<210>  13208
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13208
cuguccaagc ccgguuga                                                    18

<210>  13209
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13209
cuguccaagc ccgguuga                                                    18

<210>  13210
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13210
cuguccaagc ccgguuga                                                    18

<210>  13211
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13211
cuguccaagc ccgguuga                                                    18

<210>  13212
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13212
cuguccaagc ccgguuga                                                    18

<210>  13213
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13213
cuguccaagc ccgguuga                                                    18

<210>  13214
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13214
gguaaguucu guccaagc                                                    18

<210>  13215
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13215
gguaaguucu guccaagc                                                    18

<210>  13216
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13216
gguaaguucu guccaagc                                                    18

<210>  13217
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13217
gguaaguucu guccaagc                                                    18

<210>  13218
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13218
gguaaguucu guccaagc                                                    18

<210>  13219
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13219
gguaaguucu guccaagc                                                    18

<210>  13220
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13220
gguaaguucu guccaagc                                                    18

<210>  13221
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13221
gguaaguucu guccaagc                                                    18

<210>  13222
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13222
gguaaguucu guccaagc                                                    18

<210>  13223
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13223
gguaaguucu guccaagc                                                    18

<210>  13224
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13224
gguaaguucu guccaagc                                                    18

<210>  13225
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13225
gguaaguucu guccaagc                                                    18

<210>  13226
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13226
gguaaguucu guccaagc                                                    18

<210>  13227
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13227
gguaaguucu guccaagc                                                    18

<210>  13228
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13228
gguaaguucu guccaagc                                                    18

<210>  13229
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13229
gguaaguucu guccaagc                                                    18

<210>  13230
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13230
gguaaguucu guccaagc                                                    18

<210>  13231
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13231
gguaaguucu guccaagc                                                    18

<210>  13232
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13232
gguaaguucu guccaagc                                                    18

<210>  13233
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13233
gguaaguucu guccaagc                                                    18

<210>  13234
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13234
gguaaguucu guccaagc                                                    18

<210>  13235
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13235
guaaguucug uccaagcc                                                    18

<210>  13236
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13236
guaaguucug uccaagcc                                                    18

<210>  13237
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13237
guaaguucug uccaagcc                                                    18

<210>  13238
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13238
guaaguucug uccaagcc                                                    18

<210>  13239
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13239
guaaguucug uccaagcc                                                    18

<210>  13240
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13240
guaaguucug uccaagcc                                                    18

<210>  13241
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13241
guaaguucug uccaagcc                                                    18

<210>  13242
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13242
guaaguucug uccaagcc                                                    18

<210>  13243
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13243
guaaguucug uccaagcc                                                    18

<210>  13244
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13244
guaaguucug uccaagcc                                                    18

<210>  13245
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13245
guaaguucug uccaagcc                                                    18

<210>  13246
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13246
guaaguucug uccaagcc                                                    18

<210>  13247
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13247
guaaguucug uccaagcc                                                    18

<210>  13248
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13248
guaaguucug uccaagcc                                                    18

<210>  13249
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13249
guaaguucug uccaagcc                                                    18

<210>  13250
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13250
guaaguucug uccaagcc                                                    18

<210>  13251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13251
guaaguucug uccaagcc                                                    18

<210>  13252
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13252
guaaguucug uccaagcc                                                    18

<210>  13253
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13253
guaaguucug uccaagcc                                                    18

<210>  13254
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13254
guaaguucug uccaagcc                                                    18

<210>  13255
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13255
guaaguucug uccaagcc                                                    18

<210>  13256
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13256
agucgguaag uucugucc                                                    18

<210>  13257
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13257
agucgguaag uucugucc                                                    18

<210>  13258
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13258
agucgguaag uucugucc                                                    18

<210>  13259
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13259
agucgguaag uucugucc                                                    18

<210>  13260
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13260
agucgguaag uucugucc                                                    18

<210>  13261
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13261
agucgguaag uucugucc                                                    18

<210>  13262
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13262
agucgguaag uucugucc                                                    18

<210>  13263
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13263
agucgguaag uucugucc                                                    18

<210>  13264
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13264
agucgguaag uucugucc                                                    18

<210>  13265
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13265
agucgguaag uucugucc                                                    18

<210>  13266
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13266
agucgguaag uucugucc                                                    18

<210>  13267
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13267
agucgguaag uucugucc                                                    18

<210>  13268
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13268
agucgguaag uucugucc                                                    18

<210>  13269
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13269
agucgguaag uucugucc                                                    18

<210>  13270
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13270
agucgguaag uucugucc                                                    18

<210>  13271
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13271
agucgguaag uucugucc                                                    18

<210>  13272
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13272
agucgguaag uucugucc                                                    18

<210>  13273
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13273
agucgguaag uucugucc                                                    18

<210>  13274
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13274
agucgguaag uucugucc                                                    18

<210>  13275
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13275
agucgguaag uucugucc                                                    18

<210>  13276
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13276
agucgguaag uucugucc                                                    18

<210>  13277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13277
agucgguaag uucugucc                                                    18

<210>  13278
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13278
agucgguaag uucugucc                                                    18

<210>  13279
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13279
agucgguaag uucugucc                                                    18

<210>  13280
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13280
agucgguaag uucugucc                                                    18

<210>  13281
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13281
agucgguaag uucugucc                                                    18

<210>  13282
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13282
agucgguaag uucugucc                                                    18

<210>  13283
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13283
agucgguaag uucugucc                                                    18

<210>  13284
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13284
cuguccaagc ccgguuga                                                    18

<210>  13285
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13285
cuguccaagc ccgguuga                                                    18

<210>  13286
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13286
cuguccaagc ccgguuga                                                    18

<210>  13287
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13287
cuguccaagc ccgguuga                                                    18

<210>  13288
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13288
cuguccaagc ccgguuga                                                    18

<210>  13289
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13289
cuguccaagc ccgguuga                                                    18

<210>  13290
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13290
cuguccaagc ccgguuga                                                    18

<210>  13291
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13291
cuguccaagc ccgguuga                                                    18

<210>  13292
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13292
cuguccaagc ccgguuga                                                    18

<210>  13293
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13293
cuguccaagc ccgguuga                                                    18

<210>  13294
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13294
cuguccaagc ccgguuga                                                    18

<210>  13295
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13295
cuguccaagc ccgguuga                                                    18

<210>  13296
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13296
cuguccaagc ccgguuga                                                    18

<210>  13297
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13297
cuguccaagc ccgguuga                                                    18

<210>  13298
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13298
cuguccaagc ccgguuga                                                    18

<210>  13299
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13299
cuguccaagc ccgguuga                                                    18

<210>  13300
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13300
cuguccaagc ccgguuga                                                    18

<210>  13301
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13301
cuguccaagc ccgguuga                                                    18

<210>  13302
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13302
cuguccaagc ccgguuga                                                    18

<210>  13303
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13303
cuguccaagc ccgguuga                                                    18

<210>  13304
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13304
cuguccaagc ccgguuga                                                    18

<210>  13305
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13305
cuguccaagc ccgguuga                                                    18

<210>  13306
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13306
cuguccaagc ccgguuga                                                    18

<210>  13307
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13307
cuguccaagc ccgguuga                                                    18

<210>  13308
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13308
cuguccaagc ccgguuga                                                    18

<210>  13309
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13309
cuguccaagc ccgguuga                                                    18

<210>  13310
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13310
cuguccaagc ccgguuga                                                    18

<210>  13311
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13311
cuguccaagc ccgguuga                                                    18

<210>  13312
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13312
cuguccaagc ccgguuga                                                    18

<210>  13313
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13313
cuguccaagc ccgguuga                                                    18

<210>  13314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13314
cuguccaagc ccgguuga                                                    18

<210>  13315
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13315
cuguccaagc ccgguuga                                                    18

<210>  13316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13316
cuguccaagc ccgguuga                                                    18

<210>  13317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13317
cuguccaagc ccgguuga                                                    18

<210>  13318
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13318
cuguccaagc ccgguuga                                                    18

<210>  13319
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13319
cuguccaagc ccgguuga                                                    18

<210>  13320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13320
cuguccaagc ccgguuga                                                    18

<210>  13321
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13321
cuguccaagc ccgguuga                                                    18

<210>  13322
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13322
cuguccaagc ccgguuga                                                    18

<210>  13323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13323
cuguccaagc ccgguuga                                                    18

<210>  13324
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13324
cuguccaagc ccgguuga                                                    18

<210>  13325
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13325
cuguccaagc ccgguuga                                                    18

<210>  13326
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13326
cuguccaagc ccgguuga                                                    18

<210>  13327
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13327
cuguccaagc ccgguuga                                                    18

<210>  13328
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13328
cuguccaagc ccgguuga                                                    18

<210>  13329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13329
tcaaggaaga uggcauuuct                                                  20

<210>  13330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13330
tcaaggaaga uggcauuuct                                                  20

<210>  13331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13331
tcaaggaaga uggcauuuct                                                  20

<210>  13332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13332
tcaaggaaga uggcauuuct                                                  20

<210>  13333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13333
tcaaggaaga uggcauuuct                                                  20

<210>  13334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13334
tcaaggaaga uggcauuuct                                                  20

<210>  13335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13335
tcaaggaaga uggcauuuct                                                  20

<210>  13336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13336
tcaaggaaga uggcauuuct                                                  20

<210>  13337
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13337
tcaaggaaga uggcauuucu ag                                               22

<210>  13338
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13338
tcaaggaaga uggcauuucu ag                                               22

<210>  13339
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13339
tcaaggaaga uggcauuucu ag                                               22

<210>  13340
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13340
tcaaggaaga uggcauuucu ag                                               22

<210>  13341
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13341
tcaaggaaga uggcauuucu ag                                               22

<210>  13342
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13342
tcaaggaaga uggcauuucu ag                                               22

<210>  13343
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13343
tcaaggaaga uggcauuucu ag                                               22

<210>  13344
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13344
tcaaggaaga uggcauuucu ag                                               22

<210>  13345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13345
tcaaggaaga uggcauuuct                                                  20

<210>  13346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13346
tcaaggaaga uggcauuuct                                                  20

<210>  13347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13347
tcaaggaaga uggcauuuct                                                  20

<210>  13348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13348
tcaaggaaga uggcauuuct                                                  20

<210>  13349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13349
tcaaggaaga uggcauuuct                                                  20

<210>  13350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13350
tcaaggaaga uggcauuuct                                                  20

<210>  13351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13351
tcaaggaaga uggcauuuct                                                  20

<210>  13352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13352
tcaaggaaga uggcauuuct                                                  20

<210>  13353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13353
tcaaggaaga uggcauuuct                                                  20

<210>  13354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13354
tcaaggaaga uggcauuuct                                                  20

<210>  13355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13355
tcaaggaaga uggcauuuct                                                  20

<210>  13356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13356
tcaaggaaga uggcauuuct                                                  20

<210>  13357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13357
tcaaggaaga uggcauuuct                                                  20

<210>  13358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13358
tcaaggaaga uggcauuuct                                                  20

<210>  13359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13359
tcaaggaaga uggcauuuct                                                  20

<210>  13360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13360
tcaaggaaga uggcauuuct                                                  20

<210>  13361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13361
tcaaggaaga uggcauuuct                                                  20

<210>  13362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13362
tcaaggaaga uggcauuuct                                                  20

<210>  13363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13363
tcaaggaaga uggcauuuct                                                  20

<210>  13364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13364
tcaaggaaga uggcauuuct                                                  20

<210>  13365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13365
tcaaggaaga uggcauuuct                                                  20

<210>  13366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13366
tcaaggaaga uggcauuuct                                                  20

<210>  13367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13367
tcaaggaaga uggcauuuct                                                  20

<210>  13368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13368
tcaaggaaga uggcauuuct                                                  20

<210>  13369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13369
tcaaggaaga uggcauuuct                                                  20

<210>  13370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13370
tcaaggaaga uggcauuuct                                                  20

<210>  13371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13371
tcaaggaaga uggcauuuct                                                  20

<210>  13372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13372
tcaaggaaga uggcauuuct                                                  20

<210>  13373
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13373
tcaaggaaga uggcauuucu ag                                               22

<210>  13374
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13374
tcaaggaaga uggcauuucu ag                                               22

<210>  13375
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13375
tcaaggaaga uggcauuucu ag                                               22

<210>  13376
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13376
tcaaggaaga uggcauuucu ag                                               22

<210>  13377
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13377
tcaaggaaga uggcauuucu ag                                               22

<210>  13378
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13378
tcaaggaaga uggcauuucu ag                                               22

<210>  13379
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13379
tcaaggaaga uggcauuucu ag                                               22

<210>  13380
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13380
tcaaggaaga uggcauuucu ag                                               22

<210>  13381
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13381
tcaaggaaga uggcauuucu ag                                               22

<210>  13382
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13382
tcaaggaaga uggcauuucu ag                                               22

<210>  13383
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13383
tcaaggaaga uggcauuucu ag                                               22

<210>  13384
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13384
tcaaggaaga uggcauuucu ag                                               22

<210>  13385
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13385
tcaaggaaga uggcauuucu ag                                               22

<210>  13386
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13386
tcaaggaaga uggcauuucu ag                                               22

<210>  13387
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13387
tcaaggaaga uggcauuucu ag                                               22

<210>  13388
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13388
tcaaggaaga uggcauuucu ag                                               22

<210>  13389
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13389
tcaaggaaga uggcauuucu ag                                               22

<210>  13390
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13390
tcaaggaaga uggcauuucu ag                                               22

<210>  13391
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13391
tcaaggaaga uggcauuucu ag                                               22

<210>  13392
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13392
tcaaggaaga uggcauuucu ag                                               22

<210>  13393
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13393
tcaaggaaga uggcauuucu ag                                               22

<210>  13394
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13394
tcaaggaaga uggcauuucu ag                                               22

<210>  13395
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13395
tcaaggaaga uggcauuucu ag                                               22

<210>  13396
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13396
tcaaggaaga uggcauuucu ag                                               22

<210>  13397
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13397
tcaaggaaga uggcauuucu ag                                               22

<210>  13398
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13398
tcaaggaaga uggcauuucu ag                                               22

<210>  13399
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13399
tcaaggaaga uggcauuucu ag                                               22

<210>  13400
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13400
tcaaggaaga uggcauuucu ag                                               22

<210>  13401
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13401
ggtaagttct gtccaagc                                                    18

<210>  13402
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13402
ggtaagttct gtccaagc                                                    18

<210>  13403
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13403
ggtaagttct gtccaagc                                                    18

<210>  13404
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13404
ggtaagttct gtccaagc                                                    18

<210>  13405
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13405
ggtaagttct gtccaagc                                                    18

<210>  13406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13406
ggtaagttct gtccaagc                                                    18

<210>  13407
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13407
ggtaagttct gtccaagc                                                    18

<210>  13408
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13408
gtaagttctg tccaagcc                                                    18

<210>  13409
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13409
gtaagttctg tccaagcc                                                    18

<210>  13410
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13410
gtaagttctg tccaagcc                                                    18

<210>  13411
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13411
gtaagttctg tccaagcc                                                    18

<210>  13412
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13412
gtaagttctg tccaagcc                                                    18

<210>  13413
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13413
gtaagttctg tccaagcc                                                    18

<210>  13414
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13414
gtaagttctg tccaagcc                                                    18

<210>  13415
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13415
agtcggtaag ttctgtcc                                                    18

<210>  13416
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13416
agtcggtaag ttctgtcc                                                    18

<210>  13417
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13417
agtcggtaag ttctgtcc                                                    18

<210>  13418
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13418
agtcggtaag ttctgtcc                                                    18

<210>  13419
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13419
agtcggtaag ttctgtcc                                                    18

<210>  13420
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13420
agtcggtaag ttctgtcc                                                    18

<210>  13421
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13421
agtcggtaag ttctgtcc                                                    18

<210>  13422
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13422
agtcggtaag ttctgtcc                                                    18

<210>  13423
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13423
ctgtccaagc ccggttga                                                    18

<210>  13424
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13424
ctgtccaagc ccggttga                                                    18

<210>  13425
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13425
ctgtccaagc ccggttga                                                    18

<210>  13426
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13426
ctgtccaagc ccggttga                                                    18

<210>  13427
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13427
ctgtccaagc ccggttga                                                    18

<210>  13428
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13428
ctgtccaagc ccggttga                                                    18

<210>  13429
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13429
ctgtccaagc ccggttga                                                    18

<210>  13430
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13430
ctgtccaagc ccggttga                                                    18

<210>  13431
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13431
ctgtccaagc ccggttga                                                    18

<210>  13432
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13432
ctgtccaagc ccggttga                                                    18

<210>  13433
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13433
ggtaagttct gtccaagc                                                    18

<210>  13434
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13434
ggtaagttct gtccaagc                                                    18

<210>  13435
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13435
ggtaagttct gtccaagc                                                    18

<210>  13436
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13436
ggtaagttct gtccaagc                                                    18

<210>  13437
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13437
ggtaagttct gtccaagc                                                    18

<210>  13438
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13438
ggtaagttct gtccaagc                                                    18

<210>  13439
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13439
ggtaagttct gtccaagc                                                    18

<210>  13440
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13440
ggtaagttct gtccaagc                                                    18

<210>  13441
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13441
ggtaagttct gtccaagc                                                    18

<210>  13442
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13442
ggtaagttct gtccaagc                                                    18

<210>  13443
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13443
ggtaagttct gtccaagc                                                    18

<210>  13444
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13444
ggtaagttct gtccaagc                                                    18

<210>  13445
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13445
ggtaagttct gtccaagc                                                    18

<210>  13446
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13446
ggtaagttct gtccaagc                                                    18

<210>  13447
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13447
ggtaagttct gtccaagc                                                    18

<210>  13448
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13448
ggtaagttct gtccaagc                                                    18

<210>  13449
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13449
ggtaagttct gtccaagc                                                    18

<210>  13450
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13450
ggtaagttct gtccaagc                                                    18

<210>  13451
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13451
ggtaagttct gtccaagc                                                    18

<210>  13452
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13452
ggtaagttct gtccaagc                                                    18

<210>  13453
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13453
ggtaagttct gtccaagc                                                    18

<210>  13454
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13454
gtaagttctg tccaagcc                                                    18

<210>  13455
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13455
gtaagttctg tccaagcc                                                    18

<210>  13456
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13456
gtaagttctg tccaagcc                                                    18

<210>  13457
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13457
gtaagttctg tccaagcc                                                    18

<210>  13458
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13458
gtaagttctg tccaagcc                                                    18

<210>  13459
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13459
gtaagttctg tccaagcc                                                    18

<210>  13460
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13460
gtaagttctg tccaagcc                                                    18

<210>  13461
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13461
gtaagttctg tccaagcc                                                    18

<210>  13462
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13462
gtaagttctg tccaagcc                                                    18

<210>  13463
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13463
gtaagttctg tccaagcc                                                    18

<210>  13464
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13464
gtaagttctg tccaagcc                                                    18

<210>  13465
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13465
gtaagttctg tccaagcc                                                    18

<210>  13466
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13466
gtaagttctg tccaagcc                                                    18

<210>  13467
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13467
gtaagttctg tccaagcc                                                    18

<210>  13468
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13468
gtaagttctg tccaagcc                                                    18

<210>  13469
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13469
gtaagttctg tccaagcc                                                    18

<210>  13470
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13470
gtaagttctg tccaagcc                                                    18

<210>  13471
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13471
gtaagttctg tccaagcc                                                    18

<210>  13472
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13472
gtaagttctg tccaagcc                                                    18

<210>  13473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13473
gtaagttctg tccaagcc                                                    18

<210>  13474
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13474
gtaagttctg tccaagcc                                                    18

<210>  13475
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13475
agtcggtaag ttctgtcc                                                    18

<210>  13476
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13476
agtcggtaag ttctgtcc                                                    18

<210>  13477
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13477
agtcggtaag ttctgtcc                                                    18

<210>  13478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13478
agtcggtaag ttctgtcc                                                    18

<210>  13479
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13479
agtcggtaag ttctgtcc                                                    18

<210>  13480
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13480
agtcggtaag ttctgtcc                                                    18

<210>  13481
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13481
agtcggtaag ttctgtcc                                                    18

<210>  13482
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13482
agtcggtaag ttctgtcc                                                    18

<210>  13483
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13483
agtcggtaag ttctgtcc                                                    18

<210>  13484
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13484
agtcggtaag ttctgtcc                                                    18

<210>  13485
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13485
agtcggtaag ttctgtcc                                                    18

<210>  13486
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13486
agtcggtaag ttctgtcc                                                    18

<210>  13487
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13487
agtcggtaag ttctgtcc                                                    18

<210>  13488
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13488
agtcggtaag ttctgtcc                                                    18

<210>  13489
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13489
agtcggtaag ttctgtcc                                                    18

<210>  13490
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13490
agtcggtaag ttctgtcc                                                    18

<210>  13491
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13491
agtcggtaag ttctgtcc                                                    18

<210>  13492
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13492
agtcggtaag ttctgtcc                                                    18

<210>  13493
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13493
agtcggtaag ttctgtcc                                                    18

<210>  13494
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13494
agtcggtaag ttctgtcc                                                    18

<210>  13495
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13495
agtcggtaag ttctgtcc                                                    18

<210>  13496
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13496
agtcggtaag ttctgtcc                                                    18

<210>  13497
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13497
agtcggtaag ttctgtcc                                                    18

<210>  13498
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13498
agtcggtaag ttctgtcc                                                    18

<210>  13499
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13499
agtcggtaag ttctgtcc                                                    18

<210>  13500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13500
agtcggtaag ttctgtcc                                                    18

<210>  13501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13501
agtcggtaag ttctgtcc                                                    18

<210>  13502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13502
agtcggtaag ttctgtcc                                                    18

<210>  13503
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13503
ctgtccaagc ccggttga                                                    18

<210>  13504
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13504
ctgtccaagc ccggttga                                                    18

<210>  13505
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13505
ctgtccaagc ccggttga                                                    18

<210>  13506
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13506
ctgtccaagc ccggttga                                                    18

<210>  13507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13507
ctgtccaagc ccggttga                                                    18

<210>  13508
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13508
ctgtccaagc ccggttga                                                    18

<210>  13509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13509
ctgtccaagc ccggttga                                                    18

<210>  13510
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13510
ctgtccaagc ccggttga                                                    18

<210>  13511
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13511
ctgtccaagc ccggttga                                                    18

<210>  13512
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13512
ctgtccaagc ccggttga                                                    18

<210>  13513
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13513
ctgtccaagc ccggttga                                                    18

<210>  13514
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13514
ctgtccaagc ccggttga                                                    18

<210>  13515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13515
ctgtccaagc ccggttga                                                    18

<210>  13516
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13516
ctgtccaagc ccggttga                                                    18

<210>  13517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13517
ctgtccaagc ccggttga                                                    18

<210>  13518
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13518
ctgtccaagc ccggttga                                                    18

<210>  13519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13519
ctgtccaagc ccggttga                                                    18

<210>  13520
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13520
ctgtccaagc ccggttga                                                    18

<210>  13521
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13521
ctgtccaagc ccggttga                                                    18

<210>  13522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13522
ctgtccaagc ccggttga                                                    18

<210>  13523
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13523
ctgtccaagc ccggttga                                                    18

<210>  13524
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13524
ctgtccaagc ccggttga                                                    18

<210>  13525
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13525
ctgtccaagc ccggttga                                                    18

<210>  13526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13526
ctgtccaagc ccggttga                                                    18

<210>  13527
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13527
ctgtccaagc ccggttga                                                    18

<210>  13528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13528
ctgtccaagc ccggttga                                                    18

<210>  13529
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13529
ctgtccaagc ccggttga                                                    18

<210>  13530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13530
ctgtccaagc ccggttga                                                    18

<210>  13531
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13531
ctgtccaagc ccggttga                                                    18

<210>  13532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13532
ctgtccaagc ccggttga                                                    18

<210>  13533
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13533
ctgtccaagc ccggttga                                                    18

<210>  13534
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13534
ctgtccaagc ccggttga                                                    18

<210>  13535
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13535
ctgtccaagc ccggttga                                                    18

<210>  13536
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13536
ctgtccaagc ccggttga                                                    18

<210>  13537
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13537
ctgtccaagc ccggttga                                                    18

<210>  13538
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13538
ctgtccaagc ccggttga                                                    18

<210>  13539
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13539
ctgtccaagc ccggttga                                                    18

<210>  13540
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13540
ctgtccaagc ccggttga                                                    18

<210>  13541
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13541
ctgtccaagc ccggttga                                                    18

<210>  13542
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13542
ctgtccaagc ccggttga                                                    18

<210>  13543
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13543
ctgtccaagc ccggttga                                                    18

<210>  13544
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13544
ctgtccaagc ccggttga                                                    18

<210>  13545
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13545
ctgtccaagc ccggttga                                                    18

<210>  13546
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13546
ctgtccaagc ccggttga                                                    18

<210>  13547
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13547
ctgtccaagc ccggttga                                                    18

<210>  13548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13548
tcaaggaaga tggcatttct                                                  20

<210>  13549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13549
tcaaggaaga tggcatttct                                                  20

<210>  13550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13550
tcaaggaaga tggcatttct                                                  20

<210>  13551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13551
tcaaggaaga tggcatttct                                                  20

<210>  13552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13552
tcaaggaaga tggcatttct                                                  20

<210>  13553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13553
tcaaggaaga tggcatttct                                                  20

<210>  13554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13554
tcaaggaaga tggcatttct                                                  20

<210>  13555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13555
tcaaggaaga tggcatttct                                                  20

<210>  13556
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13556
tcaaggaaga tggcatttct ag                                               22

<210>  13557
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13557
tcaaggaaga tggcatttct ag                                               22

<210>  13558
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13558
tcaaggaaga tggcatttct ag                                               22

<210>  13559
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13559
tcaaggaaga tggcatttct ag                                               22

<210>  13560
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13560
tcaaggaaga tggcatttct ag                                               22

<210>  13561
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13561
tcaaggaaga tggcatttct ag                                               22

<210>  13562
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13562
tcaaggaaga tggcatttct ag                                               22

<210>  13563
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13563
tcaaggaaga tggcatttct ag                                               22

<210>  13564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13564
tcaaggaaga tggcatttct                                                  20

<210>  13565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13565
tcaaggaaga tggcatttct                                                  20

<210>  13566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13566
tcaaggaaga tggcatttct                                                  20

<210>  13567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13567
tcaaggaaga tggcatttct                                                  20

<210>  13568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13568
tcaaggaaga tggcatttct                                                  20

<210>  13569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13569
tcaaggaaga tggcatttct                                                  20

<210>  13570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13570
tcaaggaaga tggcatttct                                                  20

<210>  13571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13571
tcaaggaaga tggcatttct                                                  20

<210>  13572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13572
tcaaggaaga tggcatttct                                                  20

<210>  13573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13573
tcaaggaaga tggcatttct                                                  20

<210>  13574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13574
tcaaggaaga tggcatttct                                                  20

<210>  13575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13575
tcaaggaaga tggcatttct                                                  20

<210>  13576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13576
tcaaggaaga tggcatttct                                                  20

<210>  13577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13577
tcaaggaaga tggcatttct                                                  20

<210>  13578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13578
tcaaggaaga tggcatttct                                                  20

<210>  13579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13579
tcaaggaaga tggcatttct                                                  20

<210>  13580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13580
tcaaggaaga tggcatttct                                                  20

<210>  13581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13581
tcaaggaaga tggcatttct                                                  20

<210>  13582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13582
tcaaggaaga tggcatttct                                                  20

<210>  13583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13583
tcaaggaaga tggcatttct                                                  20

<210>  13584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13584
tcaaggaaga tggcatttct                                                  20

<210>  13585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13585
tcaaggaaga tggcatttct                                                  20

<210>  13586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13586
tcaaggaaga tggcatttct                                                  20

<210>  13587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13587
tcaaggaaga tggcatttct                                                  20

<210>  13588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13588
tcaaggaaga tggcatttct                                                  20

<210>  13589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13589
tcaaggaaga tggcatttct                                                  20

<210>  13590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13590
tcaaggaaga tggcatttct                                                  20

<210>  13591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  13591
tcaaggaaga tggcatttct                                                  20

<210>  13592
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13592
tcaaggaaga tggcatttct ag                                               22

<210>  13593
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13593
tcaaggaaga tggcatttct ag                                               22

<210>  13594
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13594
tcaaggaaga tggcatttct ag                                               22

<210>  13595
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13595
tcaaggaaga tggcatttct ag                                               22

<210>  13596
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13596
tcaaggaaga tggcatttct ag                                               22

<210>  13597
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13597
tcaaggaaga tggcatttct ag                                               22

<210>  13598
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13598
tcaaggaaga tggcatttct ag                                               22

<210>  13599
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13599
tcaaggaaga tggcatttct ag                                               22

<210>  13600
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13600
tcaaggaaga tggcatttct ag                                               22

<210>  13601
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13601
tcaaggaaga tggcatttct ag                                               22

<210>  13602
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13602
tcaaggaaga tggcatttct ag                                               22

<210>  13603
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13603
tcaaggaaga tggcatttct ag                                               22

<210>  13604
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13604
tcaaggaaga tggcatttct ag                                               22

<210>  13605
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13605
tcaaggaaga tggcatttct ag                                               22

<210>  13606
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13606
tcaaggaaga tggcatttct ag                                               22

<210>  13607
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13607
tcaaggaaga tggcatttct ag                                               22

<210>  13608
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13608
tcaaggaaga tggcatttct ag                                               22

<210>  13609
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13609
tcaaggaaga tggcatttct ag                                               22

<210>  13610
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13610
tcaaggaaga tggcatttct ag                                               22

<210>  13611
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13611
tcaaggaaga tggcatttct ag                                               22

<210>  13612
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13612
tcaaggaaga tggcatttct ag                                               22

<210>  13613
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13613
tcaaggaaga tggcatttct ag                                               22

<210>  13614
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13614
tcaaggaaga tggcatttct ag                                               22

<210>  13615
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13615
tcaaggaaga tggcatttct ag                                               22

<210>  13616
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13616
tcaaggaaga tggcatttct ag                                               22

<210>  13617
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13617
tcaaggaaga tggcatttct ag                                               22

<210>  13618
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13618
tcaaggaaga tggcatttct ag                                               22

<210>  13619
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  13619
tcaaggaaga tggcatttct ag                                               22

<210>  13620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13620
ggtaagttct gtccaagc                                                    18

<210>  13621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13621
ggtaagttct gtccaagc                                                    18

<210>  13622
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13622
ggtaagttct gtccaagc                                                    18

<210>  13623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13623
ggtaagttct gtccaagc                                                    18

<210>  13624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13624
ggtaagttct gtccaagc                                                    18

<210>  13625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13625
ggtaagttct gtccaagc                                                    18

<210>  13626
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13626
ggtaagttct gtccaagc                                                    18

<210>  13627
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13627
gtaagttctg tccaagcc                                                    18

<210>  13628
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13628
gtaagttctg tccaagcc                                                    18

<210>  13629
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13629
gtaagttctg tccaagcc                                                    18

<210>  13630
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13630
gtaagttctg tccaagcc                                                    18

<210>  13631
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13631
gtaagttctg tccaagcc                                                    18

<210>  13632
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13632
gtaagttctg tccaagcc                                                    18

<210>  13633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13633
gtaagttctg tccaagcc                                                    18

<210>  13634
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13634
agtcggtaag ttctgtcc                                                    18

<210>  13635
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13635
agtcggtaag ttctgtcc                                                    18

<210>  13636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13636
agtcggtaag ttctgtcc                                                    18

<210>  13637
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13637
agtcggtaag ttctgtcc                                                    18

<210>  13638
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13638
agtcggtaag ttctgtcc                                                    18

<210>  13639
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13639
agtcggtaag ttctgtcc                                                    18

<210>  13640
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13640
agtcggtaag ttctgtcc                                                    18

<210>  13641
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13641
agtcggtaag ttctgtcc                                                    18

<210>  13642
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13642
ctgtccaagc ccggttga                                                    18

<210>  13643
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13643
ctgtccaagc ccggttga                                                    18

<210>  13644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13644
ctgtccaagc ccggttga                                                    18

<210>  13645
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13645
ctgtccaagc ccggttga                                                    18

<210>  13646
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13646
ctgtccaagc ccggttga                                                    18

<210>  13647
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13647
ctgtccaagc ccggttga                                                    18

<210>  13648
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13648
ctgtccaagc ccggttga                                                    18

<210>  13649
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13649
ctgtccaagc ccggttga                                                    18

<210>  13650
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13650
ctgtccaagc ccggttga                                                    18

<210>  13651
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13651
ctgtccaagc ccggttga                                                    18

<210>  13652
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13652
ggtaagttct gtccaagc                                                    18

<210>  13653
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13653
ggtaagttct gtccaagc                                                    18

<210>  13654
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13654
ggtaagttct gtccaagc                                                    18

<210>  13655
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13655
ggtaagttct gtccaagc                                                    18

<210>  13656
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13656
ggtaagttct gtccaagc                                                    18

<210>  13657
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13657
ggtaagttct gtccaagc                                                    18

<210>  13658
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13658
ggtaagttct gtccaagc                                                    18

<210>  13659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13659
ggtaagttct gtccaagc                                                    18

<210>  13660
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13660
ggtaagttct gtccaagc                                                    18

<210>  13661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13661
ggtaagttct gtccaagc                                                    18

<210>  13662
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13662
ggtaagttct gtccaagc                                                    18

<210>  13663
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13663
ggtaagttct gtccaagc                                                    18

<210>  13664
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13664
ggtaagttct gtccaagc                                                    18

<210>  13665
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13665
ggtaagttct gtccaagc                                                    18

<210>  13666
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13666
ggtaagttct gtccaagc                                                    18

<210>  13667
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13667
ggtaagttct gtccaagc                                                    18

<210>  13668
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13668
ggtaagttct gtccaagc                                                    18

<210>  13669
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13669
ggtaagttct gtccaagc                                                    18

<210>  13670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13670
ggtaagttct gtccaagc                                                    18

<210>  13671
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13671
ggtaagttct gtccaagc                                                    18

<210>  13672
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  13672
ggtaagttct gtccaagc                                                    18

<210>  13673
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13673
gtaagttctg tccaagcc                                                    18

<210>  13674
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13674
gtaagttctg tccaagcc                                                    18

<210>  13675
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13675
gtaagttctg tccaagcc                                                    18

<210>  13676
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13676
gtaagttctg tccaagcc                                                    18

<210>  13677
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13677
gtaagttctg tccaagcc                                                    18

<210>  13678
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13678
gtaagttctg tccaagcc                                                    18

<210>  13679
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13679
gtaagttctg tccaagcc                                                    18

<210>  13680
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13680
gtaagttctg tccaagcc                                                    18

<210>  13681
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13681
gtaagttctg tccaagcc                                                    18

<210>  13682
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13682
gtaagttctg tccaagcc                                                    18

<210>  13683
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13683
gtaagttctg tccaagcc                                                    18

<210>  13684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13684
gtaagttctg tccaagcc                                                    18

<210>  13685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13685
gtaagttctg tccaagcc                                                    18

<210>  13686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13686
gtaagttctg tccaagcc                                                    18

<210>  13687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13687
gtaagttctg tccaagcc                                                    18

<210>  13688
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13688
gtaagttctg tccaagcc                                                    18

<210>  13689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13689
gtaagttctg tccaagcc                                                    18

<210>  13690
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13690
gtaagttctg tccaagcc                                                    18

<210>  13691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13691
gtaagttctg tccaagcc                                                    18

<210>  13692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13692
gtaagttctg tccaagcc                                                    18

<210>  13693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13693
gtaagttctg tccaagcc                                                    18

<210>  13694
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13694
agtcggtaag ttctgtcc                                                    18

<210>  13695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13695
agtcggtaag ttctgtcc                                                    18

<210>  13696
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13696
agtcggtaag ttctgtcc                                                    18

<210>  13697
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13697
agtcggtaag ttctgtcc                                                    18

<210>  13698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13698
agtcggtaag ttctgtcc                                                    18

<210>  13699
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13699
agtcggtaag ttctgtcc                                                    18

<210>  13700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13700
agtcggtaag ttctgtcc                                                    18

<210>  13701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13701
agtcggtaag ttctgtcc                                                    18

<210>  13702
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13702
agtcggtaag ttctgtcc                                                    18

<210>  13703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13703
agtcggtaag ttctgtcc                                                    18

<210>  13704
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13704
agtcggtaag ttctgtcc                                                    18

<210>  13705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13705
agtcggtaag ttctgtcc                                                    18

<210>  13706
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13706
agtcggtaag ttctgtcc                                                    18

<210>  13707
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13707
agtcggtaag ttctgtcc                                                    18

<210>  13708
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13708
agtcggtaag ttctgtcc                                                    18

<210>  13709
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13709
agtcggtaag ttctgtcc                                                    18

<210>  13710
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13710
agtcggtaag ttctgtcc                                                    18

<210>  13711
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13711
agtcggtaag ttctgtcc                                                    18

<210>  13712
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13712
agtcggtaag ttctgtcc                                                    18

<210>  13713
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13713
agtcggtaag ttctgtcc                                                    18

<210>  13714
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13714
agtcggtaag ttctgtcc                                                    18

<210>  13715
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13715
agtcggtaag ttctgtcc                                                    18

<210>  13716
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13716
agtcggtaag ttctgtcc                                                    18

<210>  13717
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13717
agtcggtaag ttctgtcc                                                    18

<210>  13718
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13718
agtcggtaag ttctgtcc                                                    18

<210>  13719
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13719
agtcggtaag ttctgtcc                                                    18

<210>  13720
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13720
agtcggtaag ttctgtcc                                                    18

<210>  13721
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  13721
agtcggtaag ttctgtcc                                                    18

<210>  13722
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13722
ctgtccaagc ccggttga                                                    18

<210>  13723
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13723
ctgtccaagc ccggttga                                                    18

<210>  13724
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13724
ctgtccaagc ccggttga                                                    18

<210>  13725
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13725
ctgtccaagc ccggttga                                                    18

<210>  13726
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13726
ctgtccaagc ccggttga                                                    18

<210>  13727
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13727
ctgtccaagc ccggttga                                                    18

<210>  13728
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13728
ctgtccaagc ccggttga                                                    18

<210>  13729
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13729
ctgtccaagc ccggttga                                                    18

<210>  13730
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13730
ctgtccaagc ccggttga                                                    18

<210>  13731
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13731
ctgtccaagc ccggttga                                                    18

<210>  13732
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13732
ctgtccaagc ccggttga                                                    18

<210>  13733
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13733
ctgtccaagc ccggttga                                                    18

<210>  13734
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13734
ctgtccaagc ccggttga                                                    18

<210>  13735
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13735
ctgtccaagc ccggttga                                                    18

<210>  13736
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13736
ctgtccaagc ccggttga                                                    18

<210>  13737
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13737
ctgtccaagc ccggttga                                                    18

<210>  13738
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13738
ctgtccaagc ccggttga                                                    18

<210>  13739
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13739
ctgtccaagc ccggttga                                                    18

<210>  13740
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13740
ctgtccaagc ccggttga                                                    18

<210>  13741
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13741
ctgtccaagc ccggttga                                                    18

<210>  13742
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13742
ctgtccaagc ccggttga                                                    18

<210>  13743
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13743
ctgtccaagc ccggttga                                                    18

<210>  13744
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13744
ctgtccaagc ccggttga                                                    18

<210>  13745
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13745
ctgtccaagc ccggttga                                                    18

<210>  13746
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13746
ctgtccaagc ccggttga                                                    18

<210>  13747
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13747
ctgtccaagc ccggttga                                                    18

<210>  13748
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13748
ctgtccaagc ccggttga                                                    18

<210>  13749
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13749
ctgtccaagc ccggttga                                                    18

<210>  13750
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13750
ctgtccaagc ccggttga                                                    18

<210>  13751
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13751
ctgtccaagc ccggttga                                                    18

<210>  13752
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13752
ctgtccaagc ccggttga                                                    18

<210>  13753
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13753
ctgtccaagc ccggttga                                                    18

<210>  13754
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13754
ctgtccaagc ccggttga                                                    18

<210>  13755
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13755
ctgtccaagc ccggttga                                                    18

<210>  13756
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13756
ctgtccaagc ccggttga                                                    18

<210>  13757
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13757
ctgtccaagc ccggttga                                                    18

<210>  13758
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13758
ctgtccaagc ccggttga                                                    18

<210>  13759
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13759
ctgtccaagc ccggttga                                                    18

<210>  13760
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13760
ctgtccaagc ccggttga                                                    18

<210>  13761
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13761
ctgtccaagc ccggttga                                                    18

<210>  13762
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13762
ctgtccaagc ccggttga                                                    18

<210>  13763
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13763
ctgtccaagc ccggttga                                                    18

<210>  13764
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13764
ctgtccaagc ccggttga                                                    18

<210>  13765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13765
ctgtccaagc ccggttga                                                    18

<210>  13766
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  13766
ctgtccaagc ccggttga                                                    18

<210>  13767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13767
tcaaggaaga tggcatttct                                                  20

<210>  13768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13768
tcaaggaaga tggcatttct                                                  20

<210>  13769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13769
tcaaggaaga tggcatttct                                                  20

<210>  13770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13770
tcaaggaaga tggcatttct                                                  20

<210>  13771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13771
tcaaggaaga tggcatttct                                                  20

<210>  13772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13772
tcaaggaaga tggcatttct                                                  20

<210>  13773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13773
tcaaggaaga tggcatttct                                                  20

<210>  13774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13774
tcaaggaaga tggcatttct                                                  20

<210>  13775
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13775
tcaaggaaga tggcatttct ag                                               22

<210>  13776
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13776
tcaaggaaga tggcatttct ag                                               22

<210>  13777
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13777
tcaaggaaga tggcatttct ag                                               22

<210>  13778
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13778
tcaaggaaga tggcatttct ag                                               22

<210>  13779
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13779
tcaaggaaga tggcatttct ag                                               22

<210>  13780
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13780
tcaaggaaga tggcatttct ag                                               22

<210>  13781
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13781
tcaaggaaga tggcatttct ag                                               22

<210>  13782
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13782
tcaaggaaga tggcatttct ag                                               22

<210>  13783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13783
tcaaggaaga tggcatttct                                                  20

<210>  13784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13784
tcaaggaaga tggcatttct                                                  20

<210>  13785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13785
tcaaggaaga tggcatttct                                                  20

<210>  13786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13786
tcaaggaaga tggcatttct                                                  20

<210>  13787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13787
tcaaggaaga tggcatttct                                                  20

<210>  13788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13788
tcaaggaaga tggcatttct                                                  20

<210>  13789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13789
tcaaggaaga tggcatttct                                                  20

<210>  13790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13790
tcaaggaaga tggcatttct                                                  20

<210>  13791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13791
tcaaggaaga tggcatttct                                                  20

<210>  13792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13792
tcaaggaaga tggcatttct                                                  20

<210>  13793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13793
tcaaggaaga tggcatttct                                                  20

<210>  13794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13794
tcaaggaaga tggcatttct                                                  20

<210>  13795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13795
tcaaggaaga tggcatttct                                                  20

<210>  13796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13796
tcaaggaaga tggcatttct                                                  20

<210>  13797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13797
tcaaggaaga tggcatttct                                                  20

<210>  13798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13798
tcaaggaaga tggcatttct                                                  20

<210>  13799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13799
tcaaggaaga tggcatttct                                                  20

<210>  13800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13800
tcaaggaaga tggcatttct                                                  20

<210>  13801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13801
tcaaggaaga tggcatttct                                                  20

<210>  13802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13802
tcaaggaaga tggcatttct                                                  20

<210>  13803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13803
tcaaggaaga tggcatttct                                                  20

<210>  13804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13804
tcaaggaaga tggcatttct                                                  20

<210>  13805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13805
tcaaggaaga tggcatttct                                                  20

<210>  13806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13806
tcaaggaaga tggcatttct                                                  20

<210>  13807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13807
tcaaggaaga tggcatttct                                                  20

<210>  13808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13808
tcaaggaaga tggcatttct                                                  20

<210>  13809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13809
tcaaggaaga tggcatttct                                                  20

<210>  13810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13810
tcaaggaaga tggcatttct                                                  20

<210>  13811
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13811
tcaaggaaga tggcatttct ag                                               22

<210>  13812
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13812
tcaaggaaga tggcatttct ag                                               22

<210>  13813
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13813
tcaaggaaga tggcatttct ag                                               22

<210>  13814
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13814
tcaaggaaga tggcatttct ag                                               22

<210>  13815
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13815
tcaaggaaga tggcatttct ag                                               22

<210>  13816
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13816
tcaaggaaga tggcatttct ag                                               22

<210>  13817
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13817
tcaaggaaga tggcatttct ag                                               22

<210>  13818
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13818
tcaaggaaga tggcatttct ag                                               22

<210>  13819
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13819
tcaaggaaga tggcatttct ag                                               22

<210>  13820
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13820
tcaaggaaga tggcatttct ag                                               22

<210>  13821
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13821
tcaaggaaga tggcatttct ag                                               22

<210>  13822
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13822
tcaaggaaga tggcatttct ag                                               22

<210>  13823
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13823
tcaaggaaga tggcatttct ag                                               22

<210>  13824
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13824
tcaaggaaga tggcatttct ag                                               22

<210>  13825
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13825
tcaaggaaga tggcatttct ag                                               22

<210>  13826
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13826
tcaaggaaga tggcatttct ag                                               22

<210>  13827
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13827
tcaaggaaga tggcatttct ag                                               22

<210>  13828
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13828
tcaaggaaga tggcatttct ag                                               22

<210>  13829
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13829
tcaaggaaga tggcatttct ag                                               22

<210>  13830
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13830
tcaaggaaga tggcatttct ag                                               22

<210>  13831
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13831
tcaaggaaga tggcatttct ag                                               22

<210>  13832
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13832
tcaaggaaga tggcatttct ag                                               22

<210>  13833
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13833
tcaaggaaga tggcatttct ag                                               22

<210>  13834
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13834
tcaaggaaga tggcatttct ag                                               22

<210>  13835
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13835
tcaaggaaga tggcatttct ag                                               22

<210>  13836
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13836
tcaaggaaga tggcatttct ag                                               22

<210>  13837
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13837
tcaaggaaga tggcatttct ag                                               22

<210>  13838
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  13838
tcaaggaaga tggcatttct ag                                               22

<210>  13839
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13839
gguaaguucu guccaagc                                                    18

<210>  13840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13840
gguaaguucu guccaagc                                                    18

<210>  13841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13841
gguaaguucu guccaagc                                                    18

<210>  13842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13842
gguaaguucu guccaagc                                                    18

<210>  13843
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13843
gguaaguucu guccaagc                                                    18

<210>  13844
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13844
gguaaguucu guccaagc                                                    18

<210>  13845
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  13845
gtaaguucug uccaagcc                                                    18

<210>  13846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13846
gtaaguucug uccaagcc                                                    18

<210>  13847
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13847
gtaaguucug uccaagcc                                                    18

<210>  13848
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13848
gtaaguucug uccaagcc                                                    18

<210>  13849
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13849
gtaaguucug uccaagcc                                                    18

<210>  13850
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13850
gtaaguucug uccaagcc                                                    18

<210>  13851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  13851
gtaaguucug uccaagcc                                                    18

<210>  13852
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  13852
agucgguaag uucugucc                                                    18

<210>  13853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13853
agucgguaag uucugucc                                                    18

<210>  13854
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13854
agucgguaag uucugucc                                                    18

<210>  13855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13855
agucgguaag uucugucc                                                    18

<210>  13856
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13856
agucgguaag uucugucc                                                    18

<210>  13857
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13857
agucgguaag uucugucc                                                    18

<210>  13858
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  13858
agucgguaag uucugucc                                                    18

<210>  13859
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  13859
ctguccaagc ccgguuga                                                    18

<210>  13860
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13860
ctguccaagc ccgguuga                                                    18

<210>  13861
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13861
ctguccaagc ccgguuga                                                    18

<210>  13862
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13862
ctguccaagc ccgguuga                                                    18

<210>  13863
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13863
ctguccaagc ccgguuga                                                    18

<210>  13864
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13864
ctguccaagc ccgguuga                                                    18

<210>  13865
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13865
ctguccaagc ccgguuga                                                    18

<210>  13866
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13866
ctguccaagc ccgguuga                                                    18

<210>  13867
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13867
ctguccaagc ccgguuga                                                    18

<210>  13868
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13868
ctguccaagc ccgguuga                                                    18

<210>  13869
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13869
gguaaguucu guccaagc                                                    18

<210>  13870
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13870
gguaaguucu guccaagc                                                    18

<210>  13871
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13871
gguaaguucu guccaagc                                                    18

<210>  13872
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13872
gguaaguucu guccaagc                                                    18

<210>  13873
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13873
gguaaguucu guccaagc                                                    18

<210>  13874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13874
gguaaguucu guccaagc                                                    18

<210>  13875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13875
gguaaguucu guccaagc                                                    18

<210>  13876
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13876
gguaaguucu guccaagc                                                    18

<210>  13877
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13877
gguaaguucu guccaagc                                                    18

<210>  13878
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13878
gguaaguucu guccaagc                                                    18

<210>  13879
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13879
gguaaguucu guccaagc                                                    18

<210>  13880
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13880
gguaaguucu guccaagc                                                    18

<210>  13881
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13881
gguaaguucu guccaagc                                                    18

<210>  13882
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13882
gguaaguucu guccaagc                                                    18

<210>  13883
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13883
gguaaguucu guccaagc                                                    18

<210>  13884
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13884
gtaaguucug uccaagcc                                                    18

<210>  13885
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  13885
gtaaguucug uccaagcc                                                    18

<210>  13886
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13886
gtaaguucug uccaagcc                                                    18

<210>  13887
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13887
gtaaguucug uccaagcc                                                    18

<210>  13888
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13888
gtaaguucug uccaagcc                                                    18

<210>  13889
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13889
gtaaguucug uccaagcc                                                    18

<210>  13890
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13890
gtaaguucug uccaagcc                                                    18

<210>  13891
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13891
gtaaguucug uccaagcc                                                    18

<210>  13892
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  13892
gtaaguucug uccaagcc                                                    18

<210>  13893
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  13893
gtaaguucug uccaagcc                                                    18

<210>  13894
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13894
gtaaguucug uccaagcc                                                    18

<210>  13895
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13895
gtaaguucug uccaagcc                                                    18

<210>  13896
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13896
gtaaguucug uccaagcc                                                    18

<210>  13897
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13897
gtaaguucug uccaagcc                                                    18

<210>  13898
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13898
gtaaguucug uccaagcc                                                    18

<210>  13899
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13899
gtaaguucug uccaagcc                                                    18

<210>  13900
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  13900
gtaaguucug uccaagcc                                                    18

<210>  13901
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  13901
gtaaguucug uccaagcc                                                    18

<210>  13902
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  13902
gtaaguucug uccaagcc                                                    18

<210>  13903
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13903
gtaaguucug uccaagcc                                                    18

<210>  13904
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13904
gtaaguucug uccaagcc                                                    18

<210>  13905
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13905
agucgguaag uucugucc                                                    18

<210>  13906
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13906
agucgguaag uucugucc                                                    18

<210>  13907
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13907
agucgguaag uucugucc                                                    18

<210>  13908
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  13908
agucgguaag uucugucc                                                    18

<210>  13909
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13909
agucgguaag uucugucc                                                    18

<210>  13910
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13910
agucgguaag uucugucc                                                    18

<210>  13911
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13911
agucgguaag uucugucc                                                    18

<210>  13912
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  13912
agucgguaag uucugucc                                                    18

<210>  13913
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  13913
agucgguaag uucugucc                                                    18

<210>  13914
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13914
agucgguaag uucugucc                                                    18

<210>  13915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  13915
agucgguaag uucugucc                                                    18

<210>  13916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13916
agucgguaag uucugucc                                                    18

<210>  13917
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13917
agucgguaag uucugucc                                                    18

<210>  13918
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13918
agucgguaag uucugucc                                                    18

<210>  13919
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13919
agucgguaag uucugucc                                                    18

<210>  13920
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13920
agucgguaag uucugucc                                                    18

<210>  13921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13921
agucgguaag uucugucc                                                    18

<210>  13922
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13922
agucgguaag uucugucc                                                    18

<210>  13923
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  13923
agucgguaag uucugucc                                                    18

<210>  13924
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13924
agucgguaag uucugucc                                                    18

<210>  13925
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13925
agucgguaag uucugucc                                                    18

<210>  13926
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13926
ctguccaagc ccgguuga                                                    18

<210>  13927
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13927
ctguccaagc ccgguuga                                                    18

<210>  13928
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13928
ctguccaagc ccgguuga                                                    18

<210>  13929
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13929
ctguccaagc ccgguuga                                                    18

<210>  13930
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13930
ctguccaagc ccgguuga                                                    18

<210>  13931
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13931
ctguccaagc ccgguuga                                                    18

<210>  13932
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13932
ctguccaagc ccgguuga                                                    18

<210>  13933
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13933
ctguccaagc ccgguuga                                                    18

<210>  13934
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13934
ctguccaagc ccgguuga                                                    18

<210>  13935
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13935
ctguccaagc ccgguuga                                                    18

<210>  13936
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13936
ctguccaagc ccgguuga                                                    18

<210>  13937
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13937
ctguccaagc ccgguuga                                                    18

<210>  13938
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13938
ctguccaagc ccgguuga                                                    18

<210>  13939
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13939
ctguccaagc ccgguuga                                                    18

<210>  13940
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  13940
ctguccaagc ccgguuga                                                    18

<210>  13941
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13941
ctguccaagc ccgguuga                                                    18

<210>  13942
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13942
ctguccaagc ccgguuga                                                    18

<210>  13943
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13943
ctguccaagc ccgguuga                                                    18

<210>  13944
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13944
ctguccaagc ccgguuga                                                    18

<210>  13945
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13945
ctguccaagc ccgguuga                                                    18

<210>  13946
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13946
ctguccaagc ccgguuga                                                    18

<210>  13947
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13947
ctguccaagc ccgguuga                                                    18

<210>  13948
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13948
ctguccaagc ccgguuga                                                    18

<210>  13949
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13949
ctguccaagc ccgguuga                                                    18

<210>  13950
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13950
ctguccaagc ccgguuga                                                    18

<210>  13951
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13951
ctguccaagc ccgguuga                                                    18

<210>  13952
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13952
ctguccaagc ccgguuga                                                    18

<210>  13953
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13953
ctguccaagc ccgguuga                                                    18

<210>  13954
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13954
ctguccaagc ccgguuga                                                    18

<210>  13955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13955
ctguccaagc ccgguuga                                                    18

<210>  13956
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13956
ctguccaagc ccgguuga                                                    18

<210>  13957
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13957
ctguccaagc ccgguuga                                                    18

<210>  13958
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13958
ctguccaagc ccgguuga                                                    18

<210>  13959
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13959
ctguccaagc ccgguuga                                                    18

<210>  13960
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13960
ctguccaagc ccgguuga                                                    18

<210>  13961
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13961
ctguccaagc ccgguuga                                                    18

<210>  13962
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13962
ctguccaagc ccgguuga                                                    18

<210>  13963
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13963
ctguccaagc ccgguuga                                                    18

<210>  13964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  13964
ctguccaagc ccgguuga                                                    18

<210>  13965
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13965
ctguccaagc ccgguuga                                                    18

<210>  13966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13966
ctguccaagc ccgguuga                                                    18

<210>  13967
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  13967
ctguccaagc ccgguuga                                                    18

<210>  13968
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13968
ctguccaagc ccgguuga                                                    18

<210>  13969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13969
ctguccaagc ccgguuga                                                    18

<210>  13970
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13970
ctguccaagc ccgguuga                                                    18

<210>  13971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13971
tcaaggaaga uggcauuucu                                                  20

<210>  13972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13972
tcaaggaaga uggcauuucu                                                  20

<210>  13973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13973
tcaaggaaga uggcauuucu                                                  20

<210>  13974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13974
tcaaggaaga uggcauuucu                                                  20

<210>  13975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13975
tcaaggaaga uggcauuucu                                                  20

<210>  13976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  13976
tcaaggaaga uggcauuucu                                                  20

<210>  13977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13977
tcaaggaaga uggcauuucu                                                  20

<210>  13978
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13978
tcaaggaaga uggcauuucu ag                                               22

<210>  13979
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  13979
tcaaggaaga uggcauuucu ag                                               22

<210>  13980
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13980
tcaaggaaga uggcauuucu ag                                               22

<210>  13981
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13981
tcaaggaaga uggcauuucu ag                                               22

<210>  13982
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13982
tcaaggaaga uggcauuucu ag                                               22

<210>  13983
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  13983
tcaaggaaga uggcauuucu ag                                               22

<210>  13984
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13984
tcaaggaaga uggcauuucu ag                                               22

<210>  13985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13985
tcaaggaaga uggcauuucu                                                  20

<210>  13986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13986
tcaaggaaga uggcauuucu                                                  20

<210>  13987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  13987
tcaaggaaga uggcauuucu                                                  20

<210>  13988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13988
tcaaggaaga uggcauuucu                                                  20

<210>  13989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13989
tcaaggaaga uggcauuucu                                                  20

<210>  13990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  13990
tcaaggaaga uggcauuucu                                                  20

<210>  13991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13991
tcaaggaaga uggcauuucu                                                  20

<210>  13992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  13992
tcaaggaaga uggcauuucu                                                  20

<210>  13993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  13993
tcaaggaaga uggcauuucu                                                  20

<210>  13994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13994
tcaaggaaga uggcauuucu                                                  20

<210>  13995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  13995
tcaaggaaga uggcauuucu                                                  20

<210>  13996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  13996
tcaaggaaga uggcauuucu                                                  20

<210>  13997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13997
tcaaggaaga uggcauuucu                                                  20

<210>  13998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  13998
tcaaggaaga uggcauuucu                                                  20

<210>  13999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  13999
tcaaggaaga uggcauuucu                                                  20

<210>  14000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14000
tcaaggaaga uggcauuucu                                                  20

<210>  14001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14001
tcaaggaaga uggcauuucu                                                  20

<210>  14002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14002
tcaaggaaga uggcauuucu                                                  20

<210>  14003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14003
tcaaggaaga uggcauuucu                                                  20

<210>  14004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14004
tcaaggaaga uggcauuucu                                                  20

<210>  14005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14005
tcaaggaaga uggcauuucu                                                  20

<210>  14006
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14006
tcaaggaaga uggcauuucu ag                                               22

<210>  14007
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14007
tcaaggaaga uggcauuucu ag                                               22

<210>  14008
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14008
tcaaggaaga uggcauuucu ag                                               22

<210>  14009
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14009
tcaaggaaga uggcauuucu ag                                               22

<210>  14010
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14010
tcaaggaaga uggcauuucu ag                                               22

<210>  14011
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14011
tcaaggaaga uggcauuucu ag                                               22

<210>  14012
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14012
tcaaggaaga uggcauuucu ag                                               22

<210>  14013
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14013
tcaaggaaga uggcauuucu ag                                               22

<210>  14014
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14014
tcaaggaaga uggcauuucu ag                                               22

<210>  14015
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14015
tcaaggaaga uggcauuucu ag                                               22

<210>  14016
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14016
tcaaggaaga uggcauuucu ag                                               22

<210>  14017
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14017
tcaaggaaga uggcauuucu ag                                               22

<210>  14018
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14018
tcaaggaaga uggcauuucu ag                                               22

<210>  14019
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14019
tcaaggaaga uggcauuucu ag                                               22

<210>  14020
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14020
tcaaggaaga uggcauuucu ag                                               22

<210>  14021
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14021
tcaaggaaga uggcauuucu ag                                               22

<210>  14022
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14022
tcaaggaaga uggcauuucu ag                                               22

<210>  14023
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14023
tcaaggaaga uggcauuucu ag                                               22

<210>  14024
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14024
tcaaggaaga uggcauuucu ag                                               22

<210>  14025
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14025
tcaaggaaga uggcauuucu ag                                               22

<210>  14026
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14026
tcaaggaaga uggcauuucu ag                                               22

<210>  14027
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14027
gguaaguucu guccaagc                                                    18

<210>  14028
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14028
gguaaguucu guccaagc                                                    18

<210>  14029
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14029
gguaaguucu guccaagc                                                    18

<210>  14030
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14030
gguaaguucu guccaagc                                                    18

<210>  14031
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14031
gguaaguucu guccaagc                                                    18

<210>  14032
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14032
gguaaguucu guccaagc                                                    18

<210>  14033
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14033
gtaaguucug uccaagcc                                                    18

<210>  14034
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14034
gtaaguucug uccaagcc                                                    18

<210>  14035
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14035
gtaaguucug uccaagcc                                                    18

<210>  14036
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14036
gtaaguucug uccaagcc                                                    18

<210>  14037
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14037
gtaaguucug uccaagcc                                                    18

<210>  14038
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14038
gtaaguucug uccaagcc                                                    18

<210>  14039
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14039
gtaaguucug uccaagcc                                                    18

<210>  14040
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14040
agucgguaag uucugucc                                                    18

<210>  14041
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14041
agucgguaag uucugucc                                                    18

<210>  14042
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14042
agucgguaag uucugucc                                                    18

<210>  14043
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14043
agucgguaag uucugucc                                                    18

<210>  14044
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14044
agucgguaag uucugucc                                                    18

<210>  14045
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14045
agucgguaag uucugucc                                                    18

<210>  14046
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14046
agucgguaag uucugucc                                                    18

<210>  14047
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  14047
ctguccaagc ccgguuga                                                    18

<210>  14048
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14048
ctguccaagc ccgguuga                                                    18

<210>  14049
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14049
ctguccaagc ccgguuga                                                    18

<210>  14050
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14050
ctguccaagc ccgguuga                                                    18

<210>  14051
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14051
ctguccaagc ccgguuga                                                    18

<210>  14052
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14052
ctguccaagc ccgguuga                                                    18

<210>  14053
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14053
ctguccaagc ccgguuga                                                    18

<210>  14054
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14054
ctguccaagc ccgguuga                                                    18

<210>  14055
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14055
ctguccaagc ccgguuga                                                    18

<210>  14056
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14056
ctguccaagc ccgguuga                                                    18

<210>  14057
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14057
gguaaguucu guccaagc                                                    18

<210>  14058
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14058
gguaaguucu guccaagc                                                    18

<210>  14059
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14059
gguaaguucu guccaagc                                                    18

<210>  14060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14060
gguaaguucu guccaagc                                                    18

<210>  14061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14061
gguaaguucu guccaagc                                                    18

<210>  14062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14062
gguaaguucu guccaagc                                                    18

<210>  14063
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14063
gguaaguucu guccaagc                                                    18

<210>  14064
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14064
gguaaguucu guccaagc                                                    18

<210>  14065
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14065
gguaaguucu guccaagc                                                    18

<210>  14066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14066
gguaaguucu guccaagc                                                    18

<210>  14067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14067
gguaaguucu guccaagc                                                    18

<210>  14068
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14068
gguaaguucu guccaagc                                                    18

<210>  14069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14069
gguaaguucu guccaagc                                                    18

<210>  14070
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14070
gguaaguucu guccaagc                                                    18

<210>  14071
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14071
gguaaguucu guccaagc                                                    18

<210>  14072
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14072
gtaaguucug uccaagcc                                                    18

<210>  14073
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14073
gtaaguucug uccaagcc                                                    18

<210>  14074
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14074
gtaaguucug uccaagcc                                                    18

<210>  14075
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14075
gtaaguucug uccaagcc                                                    18

<210>  14076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14076
gtaaguucug uccaagcc                                                    18

<210>  14077
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14077
gtaaguucug uccaagcc                                                    18

<210>  14078
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14078
gtaaguucug uccaagcc                                                    18

<210>  14079
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14079
gtaaguucug uccaagcc                                                    18

<210>  14080
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14080
gtaaguucug uccaagcc                                                    18

<210>  14081
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14081
gtaaguucug uccaagcc                                                    18

<210>  14082
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14082
gtaaguucug uccaagcc                                                    18

<210>  14083
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14083
gtaaguucug uccaagcc                                                    18

<210>  14084
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14084
gtaaguucug uccaagcc                                                    18

<210>  14085
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14085
gtaaguucug uccaagcc                                                    18

<210>  14086
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14086
gtaaguucug uccaagcc                                                    18

<210>  14087
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14087
gtaaguucug uccaagcc                                                    18

<210>  14088
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14088
gtaaguucug uccaagcc                                                    18

<210>  14089
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14089
gtaaguucug uccaagcc                                                    18

<210>  14090
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14090
gtaaguucug uccaagcc                                                    18

<210>  14091
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14091
gtaaguucug uccaagcc                                                    18

<210>  14092
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14092
gtaaguucug uccaagcc                                                    18

<210>  14093
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14093
agucgguaag uucugucc                                                    18

<210>  14094
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14094
agucgguaag uucugucc                                                    18

<210>  14095
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14095
agucgguaag uucugucc                                                    18

<210>  14096
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14096
agucgguaag uucugucc                                                    18

<210>  14097
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14097
agucgguaag uucugucc                                                    18

<210>  14098
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14098
agucgguaag uucugucc                                                    18

<210>  14099
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14099
agucgguaag uucugucc                                                    18

<210>  14100
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14100
agucgguaag uucugucc                                                    18

<210>  14101
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14101
agucgguaag uucugucc                                                    18

<210>  14102
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14102
agucgguaag uucugucc                                                    18

<210>  14103
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14103
agucgguaag uucugucc                                                    18

<210>  14104
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14104
agucgguaag uucugucc                                                    18

<210>  14105
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14105
agucgguaag uucugucc                                                    18

<210>  14106
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14106
agucgguaag uucugucc                                                    18

<210>  14107
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14107
agucgguaag uucugucc                                                    18

<210>  14108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14108
agucgguaag uucugucc                                                    18

<210>  14109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14109
agucgguaag uucugucc                                                    18

<210>  14110
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14110
agucgguaag uucugucc                                                    18

<210>  14111
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14111
agucgguaag uucugucc                                                    18

<210>  14112
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14112
agucgguaag uucugucc                                                    18

<210>  14113
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14113
agucgguaag uucugucc                                                    18

<210>  14114
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14114
ctguccaagc ccgguuga                                                    18

<210>  14115
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14115
ctguccaagc ccgguuga                                                    18

<210>  14116
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14116
ctguccaagc ccgguuga                                                    18

<210>  14117
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14117
ctguccaagc ccgguuga                                                    18

<210>  14118
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14118
ctguccaagc ccgguuga                                                    18

<210>  14119
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14119
ctguccaagc ccgguuga                                                    18

<210>  14120
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14120
ctguccaagc ccgguuga                                                    18

<210>  14121
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14121
ctguccaagc ccgguuga                                                    18

<210>  14122
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14122
ctguccaagc ccgguuga                                                    18

<210>  14123
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14123
ctguccaagc ccgguuga                                                    18

<210>  14124
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14124
ctguccaagc ccgguuga                                                    18

<210>  14125
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14125
ctguccaagc ccgguuga                                                    18

<210>  14126
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14126
ctguccaagc ccgguuga                                                    18

<210>  14127
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14127
ctguccaagc ccgguuga                                                    18

<210>  14128
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14128
ctguccaagc ccgguuga                                                    18

<210>  14129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14129
ctguccaagc ccgguuga                                                    18

<210>  14130
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14130
ctguccaagc ccgguuga                                                    18

<210>  14131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14131
ctguccaagc ccgguuga                                                    18

<210>  14132
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14132
ctguccaagc ccgguuga                                                    18

<210>  14133
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14133
ctguccaagc ccgguuga                                                    18

<210>  14134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14134
ctguccaagc ccgguuga                                                    18

<210>  14135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14135
ctguccaagc ccgguuga                                                    18

<210>  14136
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14136
ctguccaagc ccgguuga                                                    18

<210>  14137
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14137
ctguccaagc ccgguuga                                                    18

<210>  14138
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14138
ctguccaagc ccgguuga                                                    18

<210>  14139
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14139
ctguccaagc ccgguuga                                                    18

<210>  14140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14140
ctguccaagc ccgguuga                                                    18

<210>  14141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14141
ctguccaagc ccgguuga                                                    18

<210>  14142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14142
ctguccaagc ccgguuga                                                    18

<210>  14143
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14143
ctguccaagc ccgguuga                                                    18

<210>  14144
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14144
ctguccaagc ccgguuga                                                    18

<210>  14145
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14145
ctguccaagc ccgguuga                                                    18

<210>  14146
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14146
ctguccaagc ccgguuga                                                    18

<210>  14147
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14147
ctguccaagc ccgguuga                                                    18

<210>  14148
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14148
ctguccaagc ccgguuga                                                    18

<210>  14149
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14149
ctguccaagc ccgguuga                                                    18

<210>  14150
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14150
ctguccaagc ccgguuga                                                    18

<210>  14151
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14151
ctguccaagc ccgguuga                                                    18

<210>  14152
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14152
ctguccaagc ccgguuga                                                    18

<210>  14153
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14153
ctguccaagc ccgguuga                                                    18

<210>  14154
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14154
ctguccaagc ccgguuga                                                    18

<210>  14155
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14155
ctguccaagc ccgguuga                                                    18

<210>  14156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14156
ctguccaagc ccgguuga                                                    18

<210>  14157
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14157
ctguccaagc ccgguuga                                                    18

<210>  14158
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14158
ctguccaagc ccgguuga                                                    18

<210>  14159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14159
tcaaggaaga uggcauuucu                                                  20

<210>  14160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14160
tcaaggaaga uggcauuucu                                                  20

<210>  14161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14161
tcaaggaaga uggcauuucu                                                  20

<210>  14162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14162
tcaaggaaga uggcauuucu                                                  20

<210>  14163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14163
tcaaggaaga uggcauuucu                                                  20

<210>  14164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14164
tcaaggaaga uggcauuucu                                                  20

<210>  14165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14165
tcaaggaaga uggcauuucu                                                  20

<210>  14166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14166
tcaaggaaga uggcauuucu ag                                               22

<210>  14167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14167
tcaaggaaga uggcauuucu ag                                               22

<210>  14168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14168
tcaaggaaga uggcauuucu ag                                               22

<210>  14169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14169
tcaaggaaga uggcauuucu ag                                               22

<210>  14170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14170
tcaaggaaga uggcauuucu ag                                               22

<210>  14171
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14171
tcaaggaaga uggcauuucu ag                                               22

<210>  14172
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14172
tcaaggaaga uggcauuucu ag                                               22

<210>  14173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14173
tcaaggaaga uggcauuucu                                                  20

<210>  14174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14174
tcaaggaaga uggcauuucu                                                  20

<210>  14175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14175
tcaaggaaga uggcauuucu                                                  20

<210>  14176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14176
tcaaggaaga uggcauuucu                                                  20

<210>  14177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14177
tcaaggaaga uggcauuucu                                                  20

<210>  14178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14178
tcaaggaaga uggcauuucu                                                  20

<210>  14179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14179
tcaaggaaga uggcauuucu                                                  20

<210>  14180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14180
tcaaggaaga uggcauuucu                                                  20

<210>  14181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14181
tcaaggaaga uggcauuucu                                                  20

<210>  14182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14182
tcaaggaaga uggcauuucu                                                  20

<210>  14183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14183
tcaaggaaga uggcauuucu                                                  20

<210>  14184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14184
tcaaggaaga uggcauuucu                                                  20

<210>  14185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14185
tcaaggaaga uggcauuucu                                                  20

<210>  14186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14186
tcaaggaaga uggcauuucu                                                  20

<210>  14187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14187
tcaaggaaga uggcauuucu                                                  20

<210>  14188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14188
tcaaggaaga uggcauuucu                                                  20

<210>  14189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14189
tcaaggaaga uggcauuucu                                                  20

<210>  14190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14190
tcaaggaaga uggcauuucu                                                  20

<210>  14191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14191
tcaaggaaga uggcauuucu                                                  20

<210>  14192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14192
tcaaggaaga uggcauuucu                                                  20

<210>  14193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14193
tcaaggaaga uggcauuucu                                                  20

<210>  14194
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14194
tcaaggaaga uggcauuucu ag                                               22

<210>  14195
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14195
tcaaggaaga uggcauuucu ag                                               22

<210>  14196
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14196
tcaaggaaga uggcauuucu ag                                               22

<210>  14197
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14197
tcaaggaaga uggcauuucu ag                                               22

<210>  14198
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14198
tcaaggaaga uggcauuucu ag                                               22

<210>  14199
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14199
tcaaggaaga uggcauuucu ag                                               22

<210>  14200
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14200
tcaaggaaga uggcauuucu ag                                               22

<210>  14201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14201
tcaaggaaga uggcauuucu ag                                               22

<210>  14202
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14202
tcaaggaaga uggcauuucu ag                                               22

<210>  14203
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14203
tcaaggaaga uggcauuucu ag                                               22

<210>  14204
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14204
tcaaggaaga uggcauuucu ag                                               22

<210>  14205
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14205
tcaaggaaga uggcauuucu ag                                               22

<210>  14206
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14206
tcaaggaaga uggcauuucu ag                                               22

<210>  14207
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14207
tcaaggaaga uggcauuucu ag                                               22

<210>  14208
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14208
tcaaggaaga uggcauuucu ag                                               22

<210>  14209
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14209
tcaaggaaga uggcauuucu ag                                               22

<210>  14210
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14210
tcaaggaaga uggcauuucu ag                                               22

<210>  14211
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14211
tcaaggaaga uggcauuucu ag                                               22

<210>  14212
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14212
tcaaggaaga uggcauuucu ag                                               22

<210>  14213
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14213
tcaaggaaga uggcauuucu ag                                               22

<210>  14214
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14214
tcaaggaaga uggcauuucu ag                                               22

<210>  14215
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14215
ggtaagttct gtccaagc                                                    18

<210>  14216
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14216
ggtaagttct gtccaagc                                                    18

<210>  14217
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14217
ggtaagttct gtccaagc                                                    18

<210>  14218
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14218
ggtaagttct gtccaagc                                                    18

<210>  14219
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14219
ggtaagttct gtccaagc                                                    18

<210>  14220
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14220
ggtaagttct gtccaagc                                                    18

<210>  14221
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  14221
gtaagttctg tccaagcc                                                    18

<210>  14222
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14222
gtaagttctg tccaagcc                                                    18

<210>  14223
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14223
gtaagttctg tccaagcc                                                    18

<210>  14224
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14224
gtaagttctg tccaagcc                                                    18

<210>  14225
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14225
gtaagttctg tccaagcc                                                    18

<210>  14226
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14226
gtaagttctg tccaagcc                                                    18

<210>  14227
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  14227
gtaagttctg tccaagcc                                                    18

<210>  14228
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<400>  14228
agtcggtaag ttctgtcc                                                    18

<210>  14229
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14229
agtcggtaag ttctgtcc                                                    18

<210>  14230
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14230
agtcggtaag ttctgtcc                                                    18

<210>  14231
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14231
agtcggtaag ttctgtcc                                                    18

<210>  14232
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14232
agtcggtaag ttctgtcc                                                    18

<210>  14233
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14233
agtcggtaag ttctgtcc                                                    18

<210>  14234
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  14234
agtcggtaag ttctgtcc                                                    18

<210>  14235
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  14235
ctgtccaagc ccggttga                                                    18

<210>  14236
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14236
ctgtccaagc ccggttga                                                    18

<210>  14237
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14237
ctgtccaagc ccggttga                                                    18

<210>  14238
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14238
ctgtccaagc ccggttga                                                    18

<210>  14239
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14239
ctgtccaagc ccggttga                                                    18

<210>  14240
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14240
ctgtccaagc ccggttga                                                    18

<210>  14241
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14241
ctgtccaagc ccggttga                                                    18

<210>  14242
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14242
ctgtccaagc ccggttga                                                    18

<210>  14243
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14243
ctgtccaagc ccggttga                                                    18

<210>  14244
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14244
ctgtccaagc ccggttga                                                    18

<210>  14245
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14245
ggtaagttct gtccaagc                                                    18

<210>  14246
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14246
ggtaagttct gtccaagc                                                    18

<210>  14247
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14247
ggtaagttct gtccaagc                                                    18

<210>  14248
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14248
ggtaagttct gtccaagc                                                    18

<210>  14249
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14249
ggtaagttct gtccaagc                                                    18

<210>  14250
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14250
ggtaagttct gtccaagc                                                    18

<210>  14251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14251
ggtaagttct gtccaagc                                                    18

<210>  14252
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14252
ggtaagttct gtccaagc                                                    18

<210>  14253
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14253
ggtaagttct gtccaagc                                                    18

<210>  14254
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14254
ggtaagttct gtccaagc                                                    18

<210>  14255
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14255
ggtaagttct gtccaagc                                                    18

<210>  14256
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14256
ggtaagttct gtccaagc                                                    18

<210>  14257
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14257
ggtaagttct gtccaagc                                                    18

<210>  14258
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14258
ggtaagttct gtccaagc                                                    18

<210>  14259
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14259
ggtaagttct gtccaagc                                                    18

<210>  14260
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14260
gtaagttctg tccaagcc                                                    18

<210>  14261
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<400>  14261
gtaagttctg tccaagcc                                                    18

<210>  14262
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14262
gtaagttctg tccaagcc                                                    18

<210>  14263
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14263
gtaagttctg tccaagcc                                                    18

<210>  14264
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14264
gtaagttctg tccaagcc                                                    18

<210>  14265
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14265
gtaagttctg tccaagcc                                                    18

<210>  14266
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14266
gtaagttctg tccaagcc                                                    18

<210>  14267
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14267
gtaagttctg tccaagcc                                                    18

<210>  14268
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  14268
gtaagttctg tccaagcc                                                    18

<210>  14269
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  14269
gtaagttctg tccaagcc                                                    18

<210>  14270
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14270
gtaagttctg tccaagcc                                                    18

<210>  14271
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14271
gtaagttctg tccaagcc                                                    18

<210>  14272
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14272
gtaagttctg tccaagcc                                                    18

<210>  14273
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14273
gtaagttctg tccaagcc                                                    18

<210>  14274
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14274
gtaagttctg tccaagcc                                                    18

<210>  14275
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14275
gtaagttctg tccaagcc                                                    18

<210>  14276
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  14276
gtaagttctg tccaagcc                                                    18

<210>  14277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  14277
gtaagttctg tccaagcc                                                    18

<210>  14278
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  14278
gtaagttctg tccaagcc                                                    18

<210>  14279
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14279
gtaagttctg tccaagcc                                                    18

<210>  14280
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14280
gtaagttctg tccaagcc                                                    18

<210>  14281
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14281
agtcggtaag ttctgtcc                                                    18

<210>  14282
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14282
agtcggtaag ttctgtcc                                                    18

<210>  14283
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14283
agtcggtaag ttctgtcc                                                    18

<210>  14284
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  14284
agtcggtaag ttctgtcc                                                    18

<210>  14285
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14285
agtcggtaag ttctgtcc                                                    18

<210>  14286
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14286
agtcggtaag ttctgtcc                                                    18

<210>  14287
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14287
agtcggtaag ttctgtcc                                                    18

<210>  14288
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  14288
agtcggtaag ttctgtcc                                                    18

<210>  14289
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  14289
agtcggtaag ttctgtcc                                                    18

<210>  14290
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14290
agtcggtaag ttctgtcc                                                    18

<210>  14291
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  14291
agtcggtaag ttctgtcc                                                    18

<210>  14292
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14292
agtcggtaag ttctgtcc                                                    18

<210>  14293
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14293
agtcggtaag ttctgtcc                                                    18

<210>  14294
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14294
agtcggtaag ttctgtcc                                                    18

<210>  14295
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14295
agtcggtaag ttctgtcc                                                    18

<210>  14296
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14296
agtcggtaag ttctgtcc                                                    18

<210>  14297
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14297
agtcggtaag ttctgtcc                                                    18

<210>  14298
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14298
agtcggtaag ttctgtcc                                                    18

<210>  14299
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  14299
agtcggtaag ttctgtcc                                                    18

<210>  14300
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14300
agtcggtaag ttctgtcc                                                    18

<210>  14301
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14301
agtcggtaag ttctgtcc                                                    18

<210>  14302
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14302
ctgtccaagc ccggttga                                                    18

<210>  14303
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14303
ctgtccaagc ccggttga                                                    18

<210>  14304
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14304
ctgtccaagc ccggttga                                                    18

<210>  14305
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14305
ctgtccaagc ccggttga                                                    18

<210>  14306
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14306
ctgtccaagc ccggttga                                                    18

<210>  14307
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14307
ctgtccaagc ccggttga                                                    18

<210>  14308
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14308
ctgtccaagc ccggttga                                                    18

<210>  14309
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14309
ctgtccaagc ccggttga                                                    18

<210>  14310
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14310
ctgtccaagc ccggttga                                                    18

<210>  14311
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14311
ctgtccaagc ccggttga                                                    18

<210>  14312
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14312
ctgtccaagc ccggttga                                                    18

<210>  14313
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14313
ctgtccaagc ccggttga                                                    18

<210>  14314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14314
ctgtccaagc ccggttga                                                    18

<210>  14315
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14315
ctgtccaagc ccggttga                                                    18

<210>  14316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14316
ctgtccaagc ccggttga                                                    18

<210>  14317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14317
ctgtccaagc ccggttga                                                    18

<210>  14318
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14318
ctgtccaagc ccggttga                                                    18

<210>  14319
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14319
ctgtccaagc ccggttga                                                    18

<210>  14320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14320
ctgtccaagc ccggttga                                                    18

<210>  14321
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14321
ctgtccaagc ccggttga                                                    18

<210>  14322
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14322
ctgtccaagc ccggttga                                                    18

<210>  14323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14323
ctgtccaagc ccggttga                                                    18

<210>  14324
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14324
ctgtccaagc ccggttga                                                    18

<210>  14325
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14325
ctgtccaagc ccggttga                                                    18

<210>  14326
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14326
ctgtccaagc ccggttga                                                    18

<210>  14327
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14327
ctgtccaagc ccggttga                                                    18

<210>  14328
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14328
ctgtccaagc ccggttga                                                    18

<210>  14329
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14329
ctgtccaagc ccggttga                                                    18

<210>  14330
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14330
ctgtccaagc ccggttga                                                    18

<210>  14331
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14331
ctgtccaagc ccggttga                                                    18

<210>  14332
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14332
ctgtccaagc ccggttga                                                    18

<210>  14333
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14333
ctgtccaagc ccggttga                                                    18

<210>  14334
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14334
ctgtccaagc ccggttga                                                    18

<210>  14335
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14335
ctgtccaagc ccggttga                                                    18

<210>  14336
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14336
ctgtccaagc ccggttga                                                    18

<210>  14337
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14337
ctgtccaagc ccggttga                                                    18

<210>  14338
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14338
ctgtccaagc ccggttga                                                    18

<210>  14339
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14339
ctgtccaagc ccggttga                                                    18

<210>  14340
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14340
ctgtccaagc ccggttga                                                    18

<210>  14341
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14341
ctgtccaagc ccggttga                                                    18

<210>  14342
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14342
ctgtccaagc ccggttga                                                    18

<210>  14343
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14343
ctgtccaagc ccggttga                                                    18

<210>  14344
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14344
ctgtccaagc ccggttga                                                    18

<210>  14345
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14345
ctgtccaagc ccggttga                                                    18

<210>  14346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14346
ctgtccaagc ccggttga                                                    18

<210>  14347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14347
tcaaggaaga tggcatttct                                                  20

<210>  14348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14348
tcaaggaaga tggcatttct                                                  20

<210>  14349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14349
tcaaggaaga tggcatttct                                                  20

<210>  14350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14350
tcaaggaaga tggcatttct                                                  20

<210>  14351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14351
tcaaggaaga tggcatttct                                                  20

<210>  14352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14352
tcaaggaaga tggcatttct                                                  20

<210>  14353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14353
tcaaggaaga tggcatttct                                                  20

<210>  14354
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14354
tcaaggaaga tggcatttct ag                                               22

<210>  14355
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14355
tcaaggaaga tggcatttct ag                                               22

<210>  14356
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14356
tcaaggaaga tggcatttct ag                                               22

<210>  14357
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14357
tcaaggaaga tggcatttct ag                                               22

<210>  14358
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14358
tcaaggaaga tggcatttct ag                                               22

<210>  14359
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14359
tcaaggaaga tggcatttct ag                                               22

<210>  14360
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14360
tcaaggaaga tggcatttct ag                                               22

<210>  14361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14361
tcaaggaaga tggcatttct                                                  20

<210>  14362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14362
tcaaggaaga tggcatttct                                                  20

<210>  14363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14363
tcaaggaaga tggcatttct                                                  20

<210>  14364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14364
tcaaggaaga tggcatttct                                                  20

<210>  14365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14365
tcaaggaaga tggcatttct                                                  20

<210>  14366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14366
tcaaggaaga tggcatttct                                                  20

<210>  14367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14367
tcaaggaaga tggcatttct                                                  20

<210>  14368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14368
tcaaggaaga tggcatttct                                                  20

<210>  14369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14369
tcaaggaaga tggcatttct                                                  20

<210>  14370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14370
tcaaggaaga tggcatttct                                                  20

<210>  14371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14371
tcaaggaaga tggcatttct                                                  20

<210>  14372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14372
tcaaggaaga tggcatttct                                                  20

<210>  14373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14373
tcaaggaaga tggcatttct                                                  20

<210>  14374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14374
tcaaggaaga tggcatttct                                                  20

<210>  14375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14375
tcaaggaaga tggcatttct                                                  20

<210>  14376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14376
tcaaggaaga tggcatttct                                                  20

<210>  14377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14377
tcaaggaaga tggcatttct                                                  20

<210>  14378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14378
tcaaggaaga tggcatttct                                                  20

<210>  14379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14379
tcaaggaaga tggcatttct                                                  20

<210>  14380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14380
tcaaggaaga tggcatttct                                                  20

<210>  14381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14381
tcaaggaaga tggcatttct                                                  20

<210>  14382
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14382
tcaaggaaga tggcatttct ag                                               22

<210>  14383
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14383
tcaaggaaga tggcatttct ag                                               22

<210>  14384
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14384
tcaaggaaga tggcatttct ag                                               22

<210>  14385
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14385
tcaaggaaga tggcatttct ag                                               22

<210>  14386
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14386
tcaaggaaga tggcatttct ag                                               22

<210>  14387
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14387
tcaaggaaga tggcatttct ag                                               22

<210>  14388
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14388
tcaaggaaga tggcatttct ag                                               22

<210>  14389
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14389
tcaaggaaga tggcatttct ag                                               22

<210>  14390
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14390
tcaaggaaga tggcatttct ag                                               22

<210>  14391
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14391
tcaaggaaga tggcatttct ag                                               22

<210>  14392
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14392
tcaaggaaga tggcatttct ag                                               22

<210>  14393
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14393
tcaaggaaga tggcatttct ag                                               22

<210>  14394
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14394
tcaaggaaga tggcatttct ag                                               22

<210>  14395
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14395
tcaaggaaga tggcatttct ag                                               22

<210>  14396
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14396
tcaaggaaga tggcatttct ag                                               22

<210>  14397
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14397
tcaaggaaga tggcatttct ag                                               22

<210>  14398
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14398
tcaaggaaga tggcatttct ag                                               22

<210>  14399
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14399
tcaaggaaga tggcatttct ag                                               22

<210>  14400
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14400
tcaaggaaga tggcatttct ag                                               22

<210>  14401
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14401
tcaaggaaga tggcatttct ag                                               22

<210>  14402
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  14402
tcaaggaaga tggcatttct ag                                               22

<210>  14403
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14403
ggtaagttct gtccaagc                                                    18

<210>  14404
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14404
ggtaagttct gtccaagc                                                    18

<210>  14405
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14405
ggtaagttct gtccaagc                                                    18

<210>  14406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14406
ggtaagttct gtccaagc                                                    18

<210>  14407
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14407
ggtaagttct gtccaagc                                                    18

<210>  14408
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14408
ggtaagttct gtccaagc                                                    18

<210>  14409
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14409
gtaagttctg tccaagcc                                                    18

<210>  14410
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14410
gtaagttctg tccaagcc                                                    18

<210>  14411
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14411
gtaagttctg tccaagcc                                                    18

<210>  14412
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14412
gtaagttctg tccaagcc                                                    18

<210>  14413
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14413
gtaagttctg tccaagcc                                                    18

<210>  14414
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14414
gtaagttctg tccaagcc                                                    18

<210>  14415
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14415
gtaagttctg tccaagcc                                                    18

<210>  14416
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14416
agtcggtaag ttctgtcc                                                    18

<210>  14417
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14417
agtcggtaag ttctgtcc                                                    18

<210>  14418
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14418
agtcggtaag ttctgtcc                                                    18

<210>  14419
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14419
agtcggtaag ttctgtcc                                                    18

<210>  14420
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14420
agtcggtaag ttctgtcc                                                    18

<210>  14421
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14421
agtcggtaag ttctgtcc                                                    18

<210>  14422
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14422
agtcggtaag ttctgtcc                                                    18

<210>  14423
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<400>  14423
ctgtccaagc ccggttga                                                    18

<210>  14424
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14424
ctgtccaagc ccggttga                                                    18

<210>  14425
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14425
ctgtccaagc ccggttga                                                    18

<210>  14426
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14426
ctgtccaagc ccggttga                                                    18

<210>  14427
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14427
ctgtccaagc ccggttga                                                    18

<210>  14428
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14428
ctgtccaagc ccggttga                                                    18

<210>  14429
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14429
ctgtccaagc ccggttga                                                    18

<210>  14430
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14430
ctgtccaagc ccggttga                                                    18

<210>  14431
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14431
ctgtccaagc ccggttga                                                    18

<210>  14432
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14432
ctgtccaagc ccggttga                                                    18

<210>  14433
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14433
ggtaagttct gtccaagc                                                    18

<210>  14434
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14434
ggtaagttct gtccaagc                                                    18

<210>  14435
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14435
ggtaagttct gtccaagc                                                    18

<210>  14436
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14436
ggtaagttct gtccaagc                                                    18

<210>  14437
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14437
ggtaagttct gtccaagc                                                    18

<210>  14438
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14438
ggtaagttct gtccaagc                                                    18

<210>  14439
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14439
ggtaagttct gtccaagc                                                    18

<210>  14440
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14440
ggtaagttct gtccaagc                                                    18

<210>  14441
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14441
ggtaagttct gtccaagc                                                    18

<210>  14442
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14442
ggtaagttct gtccaagc                                                    18

<210>  14443
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14443
ggtaagttct gtccaagc                                                    18

<210>  14444
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14444
ggtaagttct gtccaagc                                                    18

<210>  14445
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14445
ggtaagttct gtccaagc                                                    18

<210>  14446
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14446
ggtaagttct gtccaagc                                                    18

<210>  14447
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14447
ggtaagttct gtccaagc                                                    18

<210>  14448
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14448
gtaagttctg tccaagcc                                                    18

<210>  14449
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14449
gtaagttctg tccaagcc                                                    18

<210>  14450
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14450
gtaagttctg tccaagcc                                                    18

<210>  14451
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14451
gtaagttctg tccaagcc                                                    18

<210>  14452
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14452
gtaagttctg tccaagcc                                                    18

<210>  14453
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14453
gtaagttctg tccaagcc                                                    18

<210>  14454
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14454
gtaagttctg tccaagcc                                                    18

<210>  14455
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14455
gtaagttctg tccaagcc                                                    18

<210>  14456
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14456
gtaagttctg tccaagcc                                                    18

<210>  14457
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14457
gtaagttctg tccaagcc                                                    18

<210>  14458
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14458
gtaagttctg tccaagcc                                                    18

<210>  14459
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14459
gtaagttctg tccaagcc                                                    18

<210>  14460
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14460
gtaagttctg tccaagcc                                                    18

<210>  14461
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14461
gtaagttctg tccaagcc                                                    18

<210>  14462
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14462
gtaagttctg tccaagcc                                                    18

<210>  14463
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14463
gtaagttctg tccaagcc                                                    18

<210>  14464
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14464
gtaagttctg tccaagcc                                                    18

<210>  14465
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14465
gtaagttctg tccaagcc                                                    18

<210>  14466
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14466
gtaagttctg tccaagcc                                                    18

<210>  14467
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14467
gtaagttctg tccaagcc                                                    18

<210>  14468
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14468
gtaagttctg tccaagcc                                                    18

<210>  14469
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14469
agtcggtaag ttctgtcc                                                    18

<210>  14470
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14470
agtcggtaag ttctgtcc                                                    18

<210>  14471
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14471
agtcggtaag ttctgtcc                                                    18

<210>  14472
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14472
agtcggtaag ttctgtcc                                                    18

<210>  14473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14473
agtcggtaag ttctgtcc                                                    18

<210>  14474
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14474
agtcggtaag ttctgtcc                                                    18

<210>  14475
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14475
agtcggtaag ttctgtcc                                                    18

<210>  14476
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14476
agtcggtaag ttctgtcc                                                    18

<210>  14477
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14477
agtcggtaag ttctgtcc                                                    18

<210>  14478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14478
agtcggtaag ttctgtcc                                                    18

<210>  14479
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14479
agtcggtaag ttctgtcc                                                    18

<210>  14480
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14480
agtcggtaag ttctgtcc                                                    18

<210>  14481
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14481
agtcggtaag ttctgtcc                                                    18

<210>  14482
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14482
agtcggtaag ttctgtcc                                                    18

<210>  14483
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14483
agtcggtaag ttctgtcc                                                    18

<210>  14484
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14484
agtcggtaag ttctgtcc                                                    18

<210>  14485
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14485
agtcggtaag ttctgtcc                                                    18

<210>  14486
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14486
agtcggtaag ttctgtcc                                                    18

<210>  14487
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14487
agtcggtaag ttctgtcc                                                    18

<210>  14488
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14488
agtcggtaag ttctgtcc                                                    18

<210>  14489
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14489
agtcggtaag ttctgtcc                                                    18

<210>  14490
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14490
ctgtccaagc ccggttga                                                    18

<210>  14491
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14491
ctgtccaagc ccggttga                                                    18

<210>  14492
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14492
ctgtccaagc ccggttga                                                    18

<210>  14493
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14493
ctgtccaagc ccggttga                                                    18

<210>  14494
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14494
ctgtccaagc ccggttga                                                    18

<210>  14495
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14495
ctgtccaagc ccggttga                                                    18

<210>  14496
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14496
ctgtccaagc ccggttga                                                    18

<210>  14497
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14497
ctgtccaagc ccggttga                                                    18

<210>  14498
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14498
ctgtccaagc ccggttga                                                    18

<210>  14499
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14499
ctgtccaagc ccggttga                                                    18

<210>  14500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14500
ctgtccaagc ccggttga                                                    18

<210>  14501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14501
ctgtccaagc ccggttga                                                    18

<210>  14502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<400>  14502
ctgtccaagc ccggttga                                                    18

<210>  14503
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14503
ctgtccaagc ccggttga                                                    18

<210>  14504
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<400>  14504
ctgtccaagc ccggttga                                                    18

<210>  14505
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14505
ctgtccaagc ccggttga                                                    18

<210>  14506
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14506
ctgtccaagc ccggttga                                                    18

<210>  14507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14507
ctgtccaagc ccggttga                                                    18

<210>  14508
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14508
ctgtccaagc ccggttga                                                    18

<210>  14509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14509
ctgtccaagc ccggttga                                                    18

<210>  14510
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14510
ctgtccaagc ccggttga                                                    18

<210>  14511
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14511
ctgtccaagc ccggttga                                                    18

<210>  14512
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14512
ctgtccaagc ccggttga                                                    18

<210>  14513
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14513
ctgtccaagc ccggttga                                                    18

<210>  14514
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14514
ctgtccaagc ccggttga                                                    18

<210>  14515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14515
ctgtccaagc ccggttga                                                    18

<210>  14516
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14516
ctgtccaagc ccggttga                                                    18

<210>  14517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14517
ctgtccaagc ccggttga                                                    18

<210>  14518
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<400>  14518
ctgtccaagc ccggttga                                                    18

<210>  14519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14519
ctgtccaagc ccggttga                                                    18

<210>  14520
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14520
ctgtccaagc ccggttga                                                    18

<210>  14521
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14521
ctgtccaagc ccggttga                                                    18

<210>  14522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14522
ctgtccaagc ccggttga                                                    18

<210>  14523
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14523
ctgtccaagc ccggttga                                                    18

<210>  14524
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14524
ctgtccaagc ccggttga                                                    18

<210>  14525
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14525
ctgtccaagc ccggttga                                                    18

<210>  14526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14526
ctgtccaagc ccggttga                                                    18

<210>  14527
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<400>  14527
ctgtccaagc ccggttga                                                    18

<210>  14528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<400>  14528
ctgtccaagc ccggttga                                                    18

<210>  14529
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14529
ctgtccaagc ccggttga                                                    18

<210>  14530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14530
ctgtccaagc ccggttga                                                    18

<210>  14531
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<400>  14531
ctgtccaagc ccggttga                                                    18

<210>  14532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<400>  14532
ctgtccaagc ccggttga                                                    18

<210>  14533
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  14533
ctgtccaagc ccggttga                                                    18

<210>  14534
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  14534
ctgtccaagc ccggttga                                                    18

<210>  14535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14535
tcaaggaaga tggcatttct                                                  20

<210>  14536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14536
tcaaggaaga tggcatttct                                                  20

<210>  14537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14537
tcaaggaaga tggcatttct                                                  20

<210>  14538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14538
tcaaggaaga tggcatttct                                                  20

<210>  14539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14539
tcaaggaaga tggcatttct                                                  20

<210>  14540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14540
tcaaggaaga tggcatttct                                                  20

<210>  14541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14541
tcaaggaaga tggcatttct                                                  20

<210>  14542
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14542
tcaaggaaga tggcatttct ag                                               22

<210>  14543
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14543
tcaaggaaga tggcatttct ag                                               22

<210>  14544
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14544
tcaaggaaga tggcatttct ag                                               22

<210>  14545
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14545
tcaaggaaga tggcatttct ag                                               22

<210>  14546
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14546
tcaaggaaga tggcatttct ag                                               22

<210>  14547
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14547
tcaaggaaga tggcatttct ag                                               22

<210>  14548
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14548
tcaaggaaga tggcatttct ag                                               22

<210>  14549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14549
tcaaggaaga tggcatttct                                                  20

<210>  14550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14550
tcaaggaaga tggcatttct                                                  20

<210>  14551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14551
tcaaggaaga tggcatttct                                                  20

<210>  14552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14552
tcaaggaaga tggcatttct                                                  20

<210>  14553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14553
tcaaggaaga tggcatttct                                                  20

<210>  14554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14554
tcaaggaaga tggcatttct                                                  20

<210>  14555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14555
tcaaggaaga tggcatttct                                                  20

<210>  14556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14556
tcaaggaaga tggcatttct                                                  20

<210>  14557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14557
tcaaggaaga tggcatttct                                                  20

<210>  14558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14558
tcaaggaaga tggcatttct                                                  20

<210>  14559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14559
tcaaggaaga tggcatttct                                                  20

<210>  14560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14560
tcaaggaaga tggcatttct                                                  20

<210>  14561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14561
tcaaggaaga tggcatttct                                                  20

<210>  14562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14562
tcaaggaaga tggcatttct                                                  20

<210>  14563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14563
tcaaggaaga tggcatttct                                                  20

<210>  14564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14564
tcaaggaaga tggcatttct                                                  20

<210>  14565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14565
tcaaggaaga tggcatttct                                                  20

<210>  14566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14566
tcaaggaaga tggcatttct                                                  20

<210>  14567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14567
tcaaggaaga tggcatttct                                                  20

<210>  14568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14568
tcaaggaaga tggcatttct                                                  20

<210>  14569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14569
tcaaggaaga tggcatttct                                                  20

<210>  14570
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14570
tcaaggaaga tggcatttct ag                                               22

<210>  14571
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14571
tcaaggaaga tggcatttct ag                                               22

<210>  14572
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14572
tcaaggaaga tggcatttct ag                                               22

<210>  14573
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14573
tcaaggaaga tggcatttct ag                                               22

<210>  14574
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14574
tcaaggaaga tggcatttct ag                                               22

<210>  14575
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14575
tcaaggaaga tggcatttct ag                                               22

<210>  14576
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14576
tcaaggaaga tggcatttct ag                                               22

<210>  14577
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14577
tcaaggaaga tggcatttct ag                                               22

<210>  14578
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14578
tcaaggaaga tggcatttct ag                                               22

<210>  14579
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14579
tcaaggaaga tggcatttct ag                                               22

<210>  14580
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14580
tcaaggaaga tggcatttct ag                                               22

<210>  14581
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14581
tcaaggaaga tggcatttct ag                                               22

<210>  14582
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14582
tcaaggaaga tggcatttct ag                                               22

<210>  14583
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14583
tcaaggaaga tggcatttct ag                                               22

<210>  14584
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14584
tcaaggaaga tggcatttct ag                                               22

<210>  14585
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14585
tcaaggaaga tggcatttct ag                                               22

<210>  14586
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14586
tcaaggaaga tggcatttct ag                                               22

<210>  14587
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14587
tcaaggaaga tggcatttct ag                                               22

<210>  14588
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14588
tcaaggaaga tggcatttct ag                                               22

<210>  14589
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14589
tcaaggaaga tggcatttct ag                                               22

<210>  14590
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  14590
tcaaggaaga tggcatttct ag                                               22

<210>  14591
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14591
gguaaguucu guccaagc                                                    18

<210>  14592
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14592
gguaaguucu guccaagc                                                    18

<210>  14593
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14593
gguaaguucu guccaagc                                                    18

<210>  14594
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14594
gguaaguucu guccaagc                                                    18

<210>  14595
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14595
gguaaguucu guccaagc                                                    18

<210>  14596
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14596
gguaaguucu guccaagc                                                    18

<210>  14597
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14597
guaaguucug uccaagcc                                                    18

<210>  14598
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14598
guaaguucug uccaagcc                                                    18

<210>  14599
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14599
guaaguucug uccaagcc                                                    18

<210>  14600
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14600
guaaguucug uccaagcc                                                    18

<210>  14601
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14601
guaaguucug uccaagcc                                                    18

<210>  14602
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14602
guaaguucug uccaagcc                                                    18

<210>  14603
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14603
agucgguaag uucugucc                                                    18

<210>  14604
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14604
agucgguaag uucugucc                                                    18

<210>  14605
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14605
agucgguaag uucugucc                                                    18

<210>  14606
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14606
agucgguaag uucugucc                                                    18

<210>  14607
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14607
agucgguaag uucugucc                                                    18

<210>  14608
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14608
agucgguaag uucugucc                                                    18

<210>  14609
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14609
agucgguaag uucugucc                                                    18

<210>  14610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14610
cuguccaagc ccgguuga                                                    18

<210>  14611
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14611
cuguccaagc ccgguuga                                                    18

<210>  14612
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14612
cuguccaagc ccgguuga                                                    18

<210>  14613
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14613
cuguccaagc ccgguuga                                                    18

<210>  14614
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14614
cuguccaagc ccgguuga                                                    18

<210>  14615
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14615
cuguccaagc ccgguuga                                                    18

<210>  14616
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14616
cuguccaagc ccgguuga                                                    18

<210>  14617
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14617
cuguccaagc ccgguuga                                                    18

<210>  14618
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14618
cuguccaagc ccgguuga                                                    18

<210>  14619
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14619
gguaaguucu guccaagc                                                    18

<210>  14620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14620
gguaaguucu guccaagc                                                    18

<210>  14621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14621
gguaaguucu guccaagc                                                    18

<210>  14622
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14622
gguaaguucu guccaagc                                                    18

<210>  14623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14623
gguaaguucu guccaagc                                                    18

<210>  14624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14624
gguaaguucu guccaagc                                                    18

<210>  14625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14625
gguaaguucu guccaagc                                                    18

<210>  14626
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14626
gguaaguucu guccaagc                                                    18

<210>  14627
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14627
gguaaguucu guccaagc                                                    18

<210>  14628
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14628
gguaaguucu guccaagc                                                    18

<210>  14629
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14629
gguaaguucu guccaagc                                                    18

<210>  14630
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14630
gguaaguucu guccaagc                                                    18

<210>  14631
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14631
gguaaguucu guccaagc                                                    18

<210>  14632
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14632
gguaaguucu guccaagc                                                    18

<210>  14633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14633
gguaaguucu guccaagc                                                    18

<210>  14634
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14634
guaaguucug uccaagcc                                                    18

<210>  14635
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14635
guaaguucug uccaagcc                                                    18

<210>  14636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14636
guaaguucug uccaagcc                                                    18

<210>  14637
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14637
guaaguucug uccaagcc                                                    18

<210>  14638
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14638
guaaguucug uccaagcc                                                    18

<210>  14639
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14639
guaaguucug uccaagcc                                                    18

<210>  14640
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14640
guaaguucug uccaagcc                                                    18

<210>  14641
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14641
guaaguucug uccaagcc                                                    18

<210>  14642
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14642
guaaguucug uccaagcc                                                    18

<210>  14643
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14643
guaaguucug uccaagcc                                                    18

<210>  14644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14644
guaaguucug uccaagcc                                                    18

<210>  14645
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14645
guaaguucug uccaagcc                                                    18

<210>  14646
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14646
guaaguucug uccaagcc                                                    18

<210>  14647
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14647
guaaguucug uccaagcc                                                    18

<210>  14648
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14648
guaaguucug uccaagcc                                                    18

<210>  14649
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14649
agucgguaag uucugucc                                                    18

<210>  14650
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14650
agucgguaag uucugucc                                                    18

<210>  14651
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14651
agucgguaag uucugucc                                                    18

<210>  14652
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14652
agucgguaag uucugucc                                                    18

<210>  14653
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14653
agucgguaag uucugucc                                                    18

<210>  14654
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14654
agucgguaag uucugucc                                                    18

<210>  14655
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14655
agucgguaag uucugucc                                                    18

<210>  14656
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14656
agucgguaag uucugucc                                                    18

<210>  14657
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14657
agucgguaag uucugucc                                                    18

<210>  14658
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14658
agucgguaag uucugucc                                                    18

<210>  14659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14659
agucgguaag uucugucc                                                    18

<210>  14660
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14660
agucgguaag uucugucc                                                    18

<210>  14661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14661
agucgguaag uucugucc                                                    18

<210>  14662
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14662
agucgguaag uucugucc                                                    18

<210>  14663
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14663
agucgguaag uucugucc                                                    18

<210>  14664
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14664
agucgguaag uucugucc                                                    18

<210>  14665
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14665
agucgguaag uucugucc                                                    18

<210>  14666
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14666
agucgguaag uucugucc                                                    18

<210>  14667
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14667
agucgguaag uucugucc                                                    18

<210>  14668
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14668
agucgguaag uucugucc                                                    18

<210>  14669
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14669
agucgguaag uucugucc                                                    18

<210>  14670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14670
cuguccaagc ccgguuga                                                    18

<210>  14671
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14671
cuguccaagc ccgguuga                                                    18

<210>  14672
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14672
cuguccaagc ccgguuga                                                    18

<210>  14673
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14673
cuguccaagc ccgguuga                                                    18

<210>  14674
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14674
cuguccaagc ccgguuga                                                    18

<210>  14675
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14675
cuguccaagc ccgguuga                                                    18

<210>  14676
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14676
cuguccaagc ccgguuga                                                    18

<210>  14677
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14677
cuguccaagc ccgguuga                                                    18

<210>  14678
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14678
cuguccaagc ccgguuga                                                    18

<210>  14679
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14679
cuguccaagc ccgguuga                                                    18

<210>  14680
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14680
cuguccaagc ccgguuga                                                    18

<210>  14681
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14681
cuguccaagc ccgguuga                                                    18

<210>  14682
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14682
cuguccaagc ccgguuga                                                    18

<210>  14683
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14683
cuguccaagc ccgguuga                                                    18

<210>  14684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14684
cuguccaagc ccgguuga                                                    18

<210>  14685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14685
cuguccaagc ccgguuga                                                    18

<210>  14686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14686
cuguccaagc ccgguuga                                                    18

<210>  14687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14687
cuguccaagc ccgguuga                                                    18

<210>  14688
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14688
cuguccaagc ccgguuga                                                    18

<210>  14689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14689
cuguccaagc ccgguuga                                                    18

<210>  14690
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14690
cuguccaagc ccgguuga                                                    18

<210>  14691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14691
cuguccaagc ccgguuga                                                    18

<210>  14692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14692
cuguccaagc ccgguuga                                                    18

<210>  14693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14693
cuguccaagc ccgguuga                                                    18

<210>  14694
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14694
cuguccaagc ccgguuga                                                    18

<210>  14695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14695
cuguccaagc ccgguuga                                                    18

<210>  14696
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14696
cuguccaagc ccgguuga                                                    18

<210>  14697
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14697
cuguccaagc ccgguuga                                                    18

<210>  14698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14698
cuguccaagc ccgguuga                                                    18

<210>  14699
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14699
cuguccaagc ccgguuga                                                    18

<210>  14700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14700
cuguccaagc ccgguuga                                                    18

<210>  14701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14701
cuguccaagc ccgguuga                                                    18

<210>  14702
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14702
cuguccaagc ccgguuga                                                    18

<210>  14703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14703
cuguccaagc ccgguuga                                                    18

<210>  14704
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14704
cuguccaagc ccgguuga                                                    18

<210>  14705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14705
cuguccaagc ccgguuga                                                    18

<210>  14706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14706
ucaaggaaga uggcauuuct                                                  20

<210>  14707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14707
ucaaggaaga uggcauuuct                                                  20

<210>  14708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14708
ucaaggaaga uggcauuuct                                                  20

<210>  14709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14709
ucaaggaaga uggcauuuct                                                  20

<210>  14710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14710
ucaaggaaga uggcauuuct                                                  20

<210>  14711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14711
ucaaggaaga uggcauuuct                                                  20

<210>  14712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14712
ucaaggaaga uggcauuuct                                                  20

<210>  14713
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14713
ucaaggaaga uggcauuucu ag                                               22

<210>  14714
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14714
ucaaggaaga uggcauuucu ag                                               22

<210>  14715
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14715
ucaaggaaga uggcauuucu ag                                               22

<210>  14716
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14716
ucaaggaaga uggcauuucu ag                                               22

<210>  14717
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14717
ucaaggaaga uggcauuucu ag                                               22

<210>  14718
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14718
ucaaggaaga uggcauuucu ag                                               22

<210>  14719
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14719
ucaaggaaga uggcauuucu ag                                               22

<210>  14720
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14720
ucaaggaaga uggcauuucu ag                                               22

<210>  14721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14721
ucaaggaaga uggcauuuct                                                  20

<210>  14722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14722
ucaaggaaga uggcauuuct                                                  20

<210>  14723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14723
ucaaggaaga uggcauuuct                                                  20

<210>  14724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14724
ucaaggaaga uggcauuuct                                                  20

<210>  14725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14725
ucaaggaaga uggcauuuct                                                  20

<210>  14726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14726
ucaaggaaga uggcauuuct                                                  20

<210>  14727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14727
ucaaggaaga uggcauuuct                                                  20

<210>  14728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14728
ucaaggaaga uggcauuuct                                                  20

<210>  14729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14729
ucaaggaaga uggcauuuct                                                  20

<210>  14730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14730
ucaaggaaga uggcauuuct                                                  20

<210>  14731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14731
ucaaggaaga uggcauuuct                                                  20

<210>  14732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14732
ucaaggaaga uggcauuuct                                                  20

<210>  14733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14733
ucaaggaaga uggcauuuct                                                  20

<210>  14734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14734
ucaaggaaga uggcauuuct                                                  20

<210>  14735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14735
ucaaggaaga uggcauuuct                                                  20

<210>  14736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14736
ucaaggaaga uggcauuuct                                                  20

<210>  14737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14737
ucaaggaaga uggcauuuct                                                  20

<210>  14738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14738
ucaaggaaga uggcauuuct                                                  20

<210>  14739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14739
ucaaggaaga uggcauuuct                                                  20

<210>  14740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14740
ucaaggaaga uggcauuuct                                                  20

<210>  14741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14741
ucaaggaaga uggcauuuct                                                  20

<210>  14742
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14742
ucaaggaaga uggcauuucu ag                                               22

<210>  14743
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14743
ucaaggaaga uggcauuucu ag                                               22

<210>  14744
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14744
ucaaggaaga uggcauuucu ag                                               22

<210>  14745
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14745
ucaaggaaga uggcauuucu ag                                               22

<210>  14746
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14746
ucaaggaaga uggcauuucu ag                                               22

<210>  14747
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14747
ucaaggaaga uggcauuucu ag                                               22

<210>  14748
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14748
ucaaggaaga uggcauuucu ag                                               22

<210>  14749
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14749
ucaaggaaga uggcauuucu ag                                               22

<210>  14750
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14750
ucaaggaaga uggcauuucu ag                                               22

<210>  14751
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14751
ucaaggaaga uggcauuucu ag                                               22

<210>  14752
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14752
ucaaggaaga uggcauuucu ag                                               22

<210>  14753
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14753
ucaaggaaga uggcauuucu ag                                               22

<210>  14754
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14754
ucaaggaaga uggcauuucu ag                                               22

<210>  14755
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14755
ucaaggaaga uggcauuucu ag                                               22

<210>  14756
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14756
ucaaggaaga uggcauuucu ag                                               22

<210>  14757
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14757
ucaaggaaga uggcauuucu ag                                               22

<210>  14758
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14758
ucaaggaaga uggcauuucu ag                                               22

<210>  14759
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14759
ucaaggaaga uggcauuucu ag                                               22

<210>  14760
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14760
ucaaggaaga uggcauuucu ag                                               22

<210>  14761
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14761
ucaaggaaga uggcauuucu ag                                               22

<210>  14762
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14762
ucaaggaaga uggcauuucu ag                                               22

<210>  14763
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14763
ucaaggaaga uggcauuucu ag                                               22

<210>  14764
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14764
ucaaggaaga uggcauuucu ag                                               22

<210>  14765
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14765
ucaaggaaga uggcauuucu ag                                               22

<210>  14766
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14766
ucaaggaaga uggcauuucu ag                                               22

<210>  14767
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14767
ucaaggaaga uggcauuucu ag                                               22

<210>  14768
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14768
ucaaggaaga uggcauuucu ag                                               22

<210>  14769
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14769
ucaaggaaga uggcauuucu ag                                               22

<210>  14770
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14770
gguaaguucu guccaagc                                                    18

<210>  14771
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14771
gguaaguucu guccaagc                                                    18

<210>  14772
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14772
gguaaguucu guccaagc                                                    18

<210>  14773
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14773
gguaaguucu guccaagc                                                    18

<210>  14774
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14774
gguaaguucu guccaagc                                                    18

<210>  14775
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14775
gguaaguucu guccaagc                                                    18

<210>  14776
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14776
guaaguucug uccaagcc                                                    18

<210>  14777
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14777
guaaguucug uccaagcc                                                    18

<210>  14778
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14778
guaaguucug uccaagcc                                                    18

<210>  14779
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14779
guaaguucug uccaagcc                                                    18

<210>  14780
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14780
guaaguucug uccaagcc                                                    18

<210>  14781
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14781
guaaguucug uccaagcc                                                    18

<210>  14782
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14782
agucgguaag uucugucc                                                    18

<210>  14783
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14783
agucgguaag uucugucc                                                    18

<210>  14784
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14784
agucgguaag uucugucc                                                    18

<210>  14785
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14785
agucgguaag uucugucc                                                    18

<210>  14786
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14786
agucgguaag uucugucc                                                    18

<210>  14787
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14787
agucgguaag uucugucc                                                    18

<210>  14788
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14788
agucgguaag uucugucc                                                    18

<210>  14789
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14789
cuguccaagc ccgguuga                                                    18

<210>  14790
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14790
cuguccaagc ccgguuga                                                    18

<210>  14791
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14791
cuguccaagc ccgguuga                                                    18

<210>  14792
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14792
cuguccaagc ccgguuga                                                    18

<210>  14793
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14793
cuguccaagc ccgguuga                                                    18

<210>  14794
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14794
cuguccaagc ccgguuga                                                    18

<210>  14795
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14795
cuguccaagc ccgguuga                                                    18

<210>  14796
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14796
cuguccaagc ccgguuga                                                    18

<210>  14797
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14797
cuguccaagc ccgguuga                                                    18

<210>  14798
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14798
gguaaguucu guccaagc                                                    18

<210>  14799
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14799
gguaaguucu guccaagc                                                    18

<210>  14800
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14800
gguaaguucu guccaagc                                                    18

<210>  14801
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14801
gguaaguucu guccaagc                                                    18

<210>  14802
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14802
gguaaguucu guccaagc                                                    18

<210>  14803
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14803
gguaaguucu guccaagc                                                    18

<210>  14804
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14804
gguaaguucu guccaagc                                                    18

<210>  14805
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14805
gguaaguucu guccaagc                                                    18

<210>  14806
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14806
gguaaguucu guccaagc                                                    18

<210>  14807
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14807
gguaaguucu guccaagc                                                    18

<210>  14808
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14808
gguaaguucu guccaagc                                                    18

<210>  14809
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14809
gguaaguucu guccaagc                                                    18

<210>  14810
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14810
gguaaguucu guccaagc                                                    18

<210>  14811
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14811
gguaaguucu guccaagc                                                    18

<210>  14812
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  14812
gguaaguucu guccaagc                                                    18

<210>  14813
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14813
guaaguucug uccaagcc                                                    18

<210>  14814
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14814
guaaguucug uccaagcc                                                    18

<210>  14815
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14815
guaaguucug uccaagcc                                                    18

<210>  14816
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14816
guaaguucug uccaagcc                                                    18

<210>  14817
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14817
guaaguucug uccaagcc                                                    18

<210>  14818
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14818
guaaguucug uccaagcc                                                    18

<210>  14819
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14819
guaaguucug uccaagcc                                                    18

<210>  14820
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14820
guaaguucug uccaagcc                                                    18

<210>  14821
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14821
guaaguucug uccaagcc                                                    18

<210>  14822
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14822
guaaguucug uccaagcc                                                    18

<210>  14823
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14823
guaaguucug uccaagcc                                                    18

<210>  14824
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14824
guaaguucug uccaagcc                                                    18

<210>  14825
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14825
guaaguucug uccaagcc                                                    18

<210>  14826
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14826
guaaguucug uccaagcc                                                    18

<210>  14827
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14827
guaaguucug uccaagcc                                                    18

<210>  14828
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14828
agucgguaag uucugucc                                                    18

<210>  14829
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14829
agucgguaag uucugucc                                                    18

<210>  14830
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14830
agucgguaag uucugucc                                                    18

<210>  14831
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14831
agucgguaag uucugucc                                                    18

<210>  14832
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14832
agucgguaag uucugucc                                                    18

<210>  14833
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14833
agucgguaag uucugucc                                                    18

<210>  14834
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14834
agucgguaag uucugucc                                                    18

<210>  14835
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14835
agucgguaag uucugucc                                                    18

<210>  14836
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14836
agucgguaag uucugucc                                                    18

<210>  14837
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14837
agucgguaag uucugucc                                                    18

<210>  14838
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14838
agucgguaag uucugucc                                                    18

<210>  14839
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14839
agucgguaag uucugucc                                                    18

<210>  14840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14840
agucgguaag uucugucc                                                    18

<210>  14841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14841
agucgguaag uucugucc                                                    18

<210>  14842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14842
agucgguaag uucugucc                                                    18

<210>  14843
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14843
agucgguaag uucugucc                                                    18

<210>  14844
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14844
agucgguaag uucugucc                                                    18

<210>  14845
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  14845
agucgguaag uucugucc                                                    18

<210>  14846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14846
agucgguaag uucugucc                                                    18

<210>  14847
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14847
agucgguaag uucugucc                                                    18

<210>  14848
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14848
agucgguaag uucugucc                                                    18

<210>  14849
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14849
cuguccaagc ccgguuga                                                    18

<210>  14850
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14850
cuguccaagc ccgguuga                                                    18

<210>  14851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14851
cuguccaagc ccgguuga                                                    18

<210>  14852
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14852
cuguccaagc ccgguuga                                                    18

<210>  14853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14853
cuguccaagc ccgguuga                                                    18

<210>  14854
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14854
cuguccaagc ccgguuga                                                    18

<210>  14855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14855
cuguccaagc ccgguuga                                                    18

<210>  14856
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14856
cuguccaagc ccgguuga                                                    18

<210>  14857
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14857
cuguccaagc ccgguuga                                                    18

<210>  14858
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14858
cuguccaagc ccgguuga                                                    18

<210>  14859
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14859
cuguccaagc ccgguuga                                                    18

<210>  14860
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14860
cuguccaagc ccgguuga                                                    18

<210>  14861
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14861
cuguccaagc ccgguuga                                                    18

<210>  14862
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14862
cuguccaagc ccgguuga                                                    18

<210>  14863
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14863
cuguccaagc ccgguuga                                                    18

<210>  14864
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14864
cuguccaagc ccgguuga                                                    18

<210>  14865
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14865
cuguccaagc ccgguuga                                                    18

<210>  14866
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14866
cuguccaagc ccgguuga                                                    18

<210>  14867
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14867
cuguccaagc ccgguuga                                                    18

<210>  14868
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14868
cuguccaagc ccgguuga                                                    18

<210>  14869
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14869
cuguccaagc ccgguuga                                                    18

<210>  14870
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14870
cuguccaagc ccgguuga                                                    18

<210>  14871
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14871
cuguccaagc ccgguuga                                                    18

<210>  14872
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14872
cuguccaagc ccgguuga                                                    18

<210>  14873
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14873
cuguccaagc ccgguuga                                                    18

<210>  14874
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14874
cuguccaagc ccgguuga                                                    18

<210>  14875
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14875
cuguccaagc ccgguuga                                                    18

<210>  14876
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14876
cuguccaagc ccgguuga                                                    18

<210>  14877
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14877
cuguccaagc ccgguuga                                                    18

<210>  14878
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14878
cuguccaagc ccgguuga                                                    18

<210>  14879
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14879
cuguccaagc ccgguuga                                                    18

<210>  14880
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14880
cuguccaagc ccgguuga                                                    18

<210>  14881
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14881
cuguccaagc ccgguuga                                                    18

<210>  14882
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14882
cuguccaagc ccgguuga                                                    18

<210>  14883
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14883
cuguccaagc ccgguuga                                                    18

<210>  14884
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14884
cuguccaagc ccgguuga                                                    18

<210>  14885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14885
ucaaggaaga uggcauuuct                                                  20

<210>  14886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14886
ucaaggaaga uggcauuuct                                                  20

<210>  14887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14887
ucaaggaaga uggcauuuct                                                  20

<210>  14888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14888
ucaaggaaga uggcauuuct                                                  20

<210>  14889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14889
ucaaggaaga uggcauuuct                                                  20

<210>  14890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14890
ucaaggaaga uggcauuuct                                                  20

<210>  14891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14891
ucaaggaaga uggcauuuct                                                  20

<210>  14892
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14892
ucaaggaaga uggcauuucu ag                                               22

<210>  14893
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14893
ucaaggaaga uggcauuucu ag                                               22

<210>  14894
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14894
ucaaggaaga uggcauuucu ag                                               22

<210>  14895
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14895
ucaaggaaga uggcauuucu ag                                               22

<210>  14896
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14896
ucaaggaaga uggcauuucu ag                                               22

<210>  14897
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14897
ucaaggaaga uggcauuucu ag                                               22

<210>  14898
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14898
ucaaggaaga uggcauuucu ag                                               22

<210>  14899
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14899
ucaaggaaga uggcauuucu ag                                               22

<210>  14900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14900
ucaaggaaga uggcauuuct                                                  20

<210>  14901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14901
ucaaggaaga uggcauuuct                                                  20

<210>  14902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14902
ucaaggaaga uggcauuuct                                                  20

<210>  14903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14903
ucaaggaaga uggcauuuct                                                  20

<210>  14904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14904
ucaaggaaga uggcauuuct                                                  20

<210>  14905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14905
ucaaggaaga uggcauuuct                                                  20

<210>  14906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14906
ucaaggaaga uggcauuuct                                                  20

<210>  14907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14907
ucaaggaaga uggcauuuct                                                  20

<210>  14908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14908
ucaaggaaga uggcauuuct                                                  20

<210>  14909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14909
ucaaggaaga uggcauuuct                                                  20

<210>  14910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14910
ucaaggaaga uggcauuuct                                                  20

<210>  14911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14911
ucaaggaaga uggcauuuct                                                  20

<210>  14912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14912
ucaaggaaga uggcauuuct                                                  20

<210>  14913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14913
ucaaggaaga uggcauuuct                                                  20

<210>  14914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14914
ucaaggaaga uggcauuuct                                                  20

<210>  14915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14915
ucaaggaaga uggcauuuct                                                  20

<210>  14916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14916
ucaaggaaga uggcauuuct                                                  20

<210>  14917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14917
ucaaggaaga uggcauuuct                                                  20

<210>  14918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14918
ucaaggaaga uggcauuuct                                                  20

<210>  14919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14919
ucaaggaaga uggcauuuct                                                  20

<210>  14920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  14920
ucaaggaaga uggcauuuct                                                  20

<210>  14921
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14921
ucaaggaaga uggcauuucu ag                                               22

<210>  14922
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14922
ucaaggaaga uggcauuucu ag                                               22

<210>  14923
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14923
ucaaggaaga uggcauuucu ag                                               22

<210>  14924
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14924
ucaaggaaga uggcauuucu ag                                               22

<210>  14925
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14925
ucaaggaaga uggcauuucu ag                                               22

<210>  14926
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14926
ucaaggaaga uggcauuucu ag                                               22

<210>  14927
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14927
ucaaggaaga uggcauuucu ag                                               22

<210>  14928
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14928
ucaaggaaga uggcauuucu ag                                               22

<210>  14929
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14929
ucaaggaaga uggcauuucu ag                                               22

<210>  14930
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14930
ucaaggaaga uggcauuucu ag                                               22

<210>  14931
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14931
ucaaggaaga uggcauuucu ag                                               22

<210>  14932
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14932
ucaaggaaga uggcauuucu ag                                               22

<210>  14933
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14933
ucaaggaaga uggcauuucu ag                                               22

<210>  14934
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14934
ucaaggaaga uggcauuucu ag                                               22

<210>  14935
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14935
ucaaggaaga uggcauuucu ag                                               22

<210>  14936
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14936
ucaaggaaga uggcauuucu ag                                               22

<210>  14937
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14937
ucaaggaaga uggcauuucu ag                                               22

<210>  14938
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14938
ucaaggaaga uggcauuucu ag                                               22

<210>  14939
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14939
ucaaggaaga uggcauuucu ag                                               22

<210>  14940
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14940
ucaaggaaga uggcauuucu ag                                               22

<210>  14941
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14941
ucaaggaaga uggcauuucu ag                                               22

<210>  14942
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14942
ucaaggaaga uggcauuucu ag                                               22

<210>  14943
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14943
ucaaggaaga uggcauuucu ag                                               22

<210>  14944
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14944
ucaaggaaga uggcauuucu ag                                               22

<210>  14945
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14945
ucaaggaaga uggcauuucu ag                                               22

<210>  14946
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14946
ucaaggaaga uggcauuucu ag                                               22

<210>  14947
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14947
ucaaggaaga uggcauuucu ag                                               22

<210>  14948
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  14948
ucaaggaaga uggcauuucu ag                                               22

<210>  14949
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14949
ggtaagttct gtccaagc                                                    18

<210>  14950
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14950
ggtaagttct gtccaagc                                                    18

<210>  14951
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14951
ggtaagttct gtccaagc                                                    18

<210>  14952
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14952
ggtaagttct gtccaagc                                                    18

<210>  14953
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14953
ggtaagttct gtccaagc                                                    18

<210>  14954
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14954
ggtaagttct gtccaagc                                                    18

<210>  14955
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14955
gtaagttctg tccaagcc                                                    18

<210>  14956
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14956
gtaagttctg tccaagcc                                                    18

<210>  14957
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14957
gtaagttctg tccaagcc                                                    18

<210>  14958
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14958
gtaagttctg tccaagcc                                                    18

<210>  14959
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14959
gtaagttctg tccaagcc                                                    18

<210>  14960
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14960
gtaagttctg tccaagcc                                                    18

<210>  14961
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14961
agtcggtaag ttctgtcc                                                    18

<210>  14962
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14962
agtcggtaag ttctgtcc                                                    18

<210>  14963
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14963
agtcggtaag ttctgtcc                                                    18

<210>  14964
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14964
agtcggtaag ttctgtcc                                                    18

<210>  14965
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14965
agtcggtaag ttctgtcc                                                    18

<210>  14966
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14966
agtcggtaag ttctgtcc                                                    18

<210>  14967
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14967
agtcggtaag ttctgtcc                                                    18

<210>  14968
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14968
ctgtccaagc ccggttga                                                    18

<210>  14969
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14969
ctgtccaagc ccggttga                                                    18

<210>  14970
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14970
ctgtccaagc ccggttga                                                    18

<210>  14971
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14971
ctgtccaagc ccggttga                                                    18

<210>  14972
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14972
ctgtccaagc ccggttga                                                    18

<210>  14973
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14973
ctgtccaagc ccggttga                                                    18

<210>  14974
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14974
ctgtccaagc ccggttga                                                    18

<210>  14975
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14975
ctgtccaagc ccggttga                                                    18

<210>  14976
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14976
ctgtccaagc ccggttga                                                    18

<210>  14977
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14977
ggtaagttct gtccaagc                                                    18

<210>  14978
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14978
ggtaagttct gtccaagc                                                    18

<210>  14979
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14979
ggtaagttct gtccaagc                                                    18

<210>  14980
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14980
ggtaagttct gtccaagc                                                    18

<210>  14981
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14981
ggtaagttct gtccaagc                                                    18

<210>  14982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14982
ggtaagttct gtccaagc                                                    18

<210>  14983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14983
ggtaagttct gtccaagc                                                    18

<210>  14984
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14984
ggtaagttct gtccaagc                                                    18

<210>  14985
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14985
ggtaagttct gtccaagc                                                    18

<210>  14986
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14986
ggtaagttct gtccaagc                                                    18

<210>  14987
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14987
ggtaagttct gtccaagc                                                    18

<210>  14988
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14988
ggtaagttct gtccaagc                                                    18

<210>  14989
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14989
ggtaagttct gtccaagc                                                    18

<210>  14990
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14990
ggtaagttct gtccaagc                                                    18

<210>  14991
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14991
ggtaagttct gtccaagc                                                    18

<210>  14992
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14992
gtaagttctg tccaagcc                                                    18

<210>  14993
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14993
gtaagttctg tccaagcc                                                    18

<210>  14994
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14994
gtaagttctg tccaagcc                                                    18

<210>  14995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14995
gtaagttctg tccaagcc                                                    18

<210>  14996
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14996
gtaagttctg tccaagcc                                                    18

<210>  14997
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14997
gtaagttctg tccaagcc                                                    18

<210>  14998
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14998
gtaagttctg tccaagcc                                                    18

<210>  14999
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  14999
gtaagttctg tccaagcc                                                    18

<210>  15000
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15000
gtaagttctg tccaagcc                                                    18

<210>  15001
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15001
gtaagttctg tccaagcc                                                    18

<210>  15002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15002
gtaagttctg tccaagcc                                                    18

<210>  15003
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15003
gtaagttctg tccaagcc                                                    18

<210>  15004
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15004
gtaagttctg tccaagcc                                                    18

<210>  15005
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15005
gtaagttctg tccaagcc                                                    18

<210>  15006
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15006
gtaagttctg tccaagcc                                                    18

<210>  15007
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15007
agtcggtaag ttctgtcc                                                    18

<210>  15008
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15008
agtcggtaag ttctgtcc                                                    18

<210>  15009
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15009
agtcggtaag ttctgtcc                                                    18

<210>  15010
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15010
agtcggtaag ttctgtcc                                                    18

<210>  15011
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15011
agtcggtaag ttctgtcc                                                    18

<210>  15012
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15012
agtcggtaag ttctgtcc                                                    18

<210>  15013
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15013
agtcggtaag ttctgtcc                                                    18

<210>  15014
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15014
agtcggtaag ttctgtcc                                                    18

<210>  15015
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15015
agtcggtaag ttctgtcc                                                    18

<210>  15016
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15016
agtcggtaag ttctgtcc                                                    18

<210>  15017
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15017
agtcggtaag ttctgtcc                                                    18

<210>  15018
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15018
agtcggtaag ttctgtcc                                                    18

<210>  15019
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15019
agtcggtaag ttctgtcc                                                    18

<210>  15020
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15020
agtcggtaag ttctgtcc                                                    18

<210>  15021
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15021
agtcggtaag ttctgtcc                                                    18

<210>  15022
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15022
agtcggtaag ttctgtcc                                                    18

<210>  15023
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15023
agtcggtaag ttctgtcc                                                    18

<210>  15024
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15024
agtcggtaag ttctgtcc                                                    18

<210>  15025
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15025
agtcggtaag ttctgtcc                                                    18

<210>  15026
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15026
agtcggtaag ttctgtcc                                                    18

<210>  15027
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15027
agtcggtaag ttctgtcc                                                    18

<210>  15028
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15028
ctgtccaagc ccggttga                                                    18

<210>  15029
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15029
ctgtccaagc ccggttga                                                    18

<210>  15030
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15030
ctgtccaagc ccggttga                                                    18

<210>  15031
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15031
ctgtccaagc ccggttga                                                    18

<210>  15032
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15032
ctgtccaagc ccggttga                                                    18

<210>  15033
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15033
ctgtccaagc ccggttga                                                    18

<210>  15034
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15034
ctgtccaagc ccggttga                                                    18

<210>  15035
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15035
ctgtccaagc ccggttga                                                    18

<210>  15036
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15036
ctgtccaagc ccggttga                                                    18

<210>  15037
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15037
ctgtccaagc ccggttga                                                    18

<210>  15038
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15038
ctgtccaagc ccggttga                                                    18

<210>  15039
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15039
ctgtccaagc ccggttga                                                    18

<210>  15040
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15040
ctgtccaagc ccggttga                                                    18

<210>  15041
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15041
ctgtccaagc ccggttga                                                    18

<210>  15042
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15042
ctgtccaagc ccggttga                                                    18

<210>  15043
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15043
ctgtccaagc ccggttga                                                    18

<210>  15044
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15044
ctgtccaagc ccggttga                                                    18

<210>  15045
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15045
ctgtccaagc ccggttga                                                    18

<210>  15046
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15046
ctgtccaagc ccggttga                                                    18

<210>  15047
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15047
ctgtccaagc ccggttga                                                    18

<210>  15048
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15048
ctgtccaagc ccggttga                                                    18

<210>  15049
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15049
ctgtccaagc ccggttga                                                    18

<210>  15050
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15050
ctgtccaagc ccggttga                                                    18

<210>  15051
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15051
ctgtccaagc ccggttga                                                    18

<210>  15052
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15052
ctgtccaagc ccggttga                                                    18

<210>  15053
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15053
ctgtccaagc ccggttga                                                    18

<210>  15054
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15054
ctgtccaagc ccggttga                                                    18

<210>  15055
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15055
ctgtccaagc ccggttga                                                    18

<210>  15056
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15056
ctgtccaagc ccggttga                                                    18

<210>  15057
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15057
ctgtccaagc ccggttga                                                    18

<210>  15058
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15058
ctgtccaagc ccggttga                                                    18

<210>  15059
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15059
ctgtccaagc ccggttga                                                    18

<210>  15060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15060
ctgtccaagc ccggttga                                                    18

<210>  15061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15061
ctgtccaagc ccggttga                                                    18

<210>  15062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15062
ctgtccaagc ccggttga                                                    18

<210>  15063
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15063
ctgtccaagc ccggttga                                                    18

<210>  15064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15064
tcaaggaaga tggcatttct                                                  20

<210>  15065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15065
tcaaggaaga tggcatttct                                                  20

<210>  15066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15066
tcaaggaaga tggcatttct                                                  20

<210>  15067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15067
tcaaggaaga tggcatttct                                                  20

<210>  15068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15068
tcaaggaaga tggcatttct                                                  20

<210>  15069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15069
tcaaggaaga tggcatttct                                                  20

<210>  15070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15070
tcaaggaaga tggcatttct                                                  20

<210>  15071
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15071
tcaaggaaga tggcatttct ag                                               22

<210>  15072
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15072
tcaaggaaga tggcatttct ag                                               22

<210>  15073
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15073
tcaaggaaga tggcatttct ag                                               22

<210>  15074
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15074
tcaaggaaga tggcatttct ag                                               22

<210>  15075
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15075
tcaaggaaga tggcatttct ag                                               22

<210>  15076
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15076
tcaaggaaga tggcatttct ag                                               22

<210>  15077
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15077
tcaaggaaga tggcatttct ag                                               22

<210>  15078
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15078
tcaaggaaga tggcatttct ag                                               22

<210>  15079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15079
tcaaggaaga tggcatttct                                                  20

<210>  15080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15080
tcaaggaaga tggcatttct                                                  20

<210>  15081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15081
tcaaggaaga tggcatttct                                                  20

<210>  15082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15082
tcaaggaaga tggcatttct                                                  20

<210>  15083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15083
tcaaggaaga tggcatttct                                                  20

<210>  15084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15084
tcaaggaaga tggcatttct                                                  20

<210>  15085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15085
tcaaggaaga tggcatttct                                                  20

<210>  15086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15086
tcaaggaaga tggcatttct                                                  20

<210>  15087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15087
tcaaggaaga tggcatttct                                                  20

<210>  15088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15088
tcaaggaaga tggcatttct                                                  20

<210>  15089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15089
tcaaggaaga tggcatttct                                                  20

<210>  15090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15090
tcaaggaaga tggcatttct                                                  20

<210>  15091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15091
tcaaggaaga tggcatttct                                                  20

<210>  15092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15092
tcaaggaaga tggcatttct                                                  20

<210>  15093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15093
tcaaggaaga tggcatttct                                                  20

<210>  15094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15094
tcaaggaaga tggcatttct                                                  20

<210>  15095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15095
tcaaggaaga tggcatttct                                                  20

<210>  15096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15096
tcaaggaaga tggcatttct                                                  20

<210>  15097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15097
tcaaggaaga tggcatttct                                                  20

<210>  15098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15098
tcaaggaaga tggcatttct                                                  20

<210>  15099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15099
tcaaggaaga tggcatttct                                                  20

<210>  15100
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15100
tcaaggaaga tggcatttct ag                                               22

<210>  15101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15101
tcaaggaaga tggcatttct ag                                               22

<210>  15102
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15102
tcaaggaaga tggcatttct ag                                               22

<210>  15103
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15103
tcaaggaaga tggcatttct ag                                               22

<210>  15104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15104
tcaaggaaga tggcatttct ag                                               22

<210>  15105
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15105
tcaaggaaga tggcatttct ag                                               22

<210>  15106
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15106
tcaaggaaga tggcatttct ag                                               22

<210>  15107
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15107
tcaaggaaga tggcatttct ag                                               22

<210>  15108
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15108
tcaaggaaga tggcatttct ag                                               22

<210>  15109
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15109
tcaaggaaga tggcatttct ag                                               22

<210>  15110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15110
tcaaggaaga tggcatttct ag                                               22

<210>  15111
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15111
tcaaggaaga tggcatttct ag                                               22

<210>  15112
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15112
tcaaggaaga tggcatttct ag                                               22

<210>  15113
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15113
tcaaggaaga tggcatttct ag                                               22

<210>  15114
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15114
tcaaggaaga tggcatttct ag                                               22

<210>  15115
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15115
tcaaggaaga tggcatttct ag                                               22

<210>  15116
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15116
tcaaggaaga tggcatttct ag                                               22

<210>  15117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15117
tcaaggaaga tggcatttct ag                                               22

<210>  15118
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15118
tcaaggaaga tggcatttct ag                                               22

<210>  15119
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15119
tcaaggaaga tggcatttct ag                                               22

<210>  15120
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15120
tcaaggaaga tggcatttct ag                                               22

<210>  15121
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15121
tcaaggaaga tggcatttct ag                                               22

<210>  15122
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15122
tcaaggaaga tggcatttct ag                                               22

<210>  15123
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15123
tcaaggaaga tggcatttct ag                                               22

<210>  15124
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15124
tcaaggaaga tggcatttct ag                                               22

<210>  15125
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15125
tcaaggaaga tggcatttct ag                                               22

<210>  15126
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15126
tcaaggaaga tggcatttct ag                                               22

<210>  15127
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15127
tcaaggaaga tggcatttct ag                                               22

<210>  15128
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15128
ggtaagttct gtccaagc                                                    18

<210>  15129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15129
ggtaagttct gtccaagc                                                    18

<210>  15130
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15130
ggtaagttct gtccaagc                                                    18

<210>  15131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15131
ggtaagttct gtccaagc                                                    18

<210>  15132
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15132
ggtaagttct gtccaagc                                                    18

<210>  15133
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15133
ggtaagttct gtccaagc                                                    18

<210>  15134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15134
gtaagttctg tccaagcc                                                    18

<210>  15135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15135
gtaagttctg tccaagcc                                                    18

<210>  15136
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15136
gtaagttctg tccaagcc                                                    18

<210>  15137
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15137
gtaagttctg tccaagcc                                                    18

<210>  15138
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15138
gtaagttctg tccaagcc                                                    18

<210>  15139
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15139
gtaagttctg tccaagcc                                                    18

<210>  15140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15140
agtcggtaag ttctgtcc                                                    18

<210>  15141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15141
agtcggtaag ttctgtcc                                                    18

<210>  15142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15142
agtcggtaag ttctgtcc                                                    18

<210>  15143
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15143
agtcggtaag ttctgtcc                                                    18

<210>  15144
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15144
agtcggtaag ttctgtcc                                                    18

<210>  15145
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15145
agtcggtaag ttctgtcc                                                    18

<210>  15146
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15146
agtcggtaag ttctgtcc                                                    18

<210>  15147
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15147
ctgtccaagc ccggttga                                                    18

<210>  15148
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15148
ctgtccaagc ccggttga                                                    18

<210>  15149
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15149
ctgtccaagc ccggttga                                                    18

<210>  15150
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15150
ctgtccaagc ccggttga                                                    18

<210>  15151
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15151
ctgtccaagc ccggttga                                                    18

<210>  15152
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15152
ctgtccaagc ccggttga                                                    18

<210>  15153
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15153
ctgtccaagc ccggttga                                                    18

<210>  15154
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15154
ctgtccaagc ccggttga                                                    18

<210>  15155
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15155
ctgtccaagc ccggttga                                                    18

<210>  15156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15156
ggtaagttct gtccaagc                                                    18

<210>  15157
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15157
ggtaagttct gtccaagc                                                    18

<210>  15158
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15158
ggtaagttct gtccaagc                                                    18

<210>  15159
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15159
ggtaagttct gtccaagc                                                    18

<210>  15160
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15160
ggtaagttct gtccaagc                                                    18

<210>  15161
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15161
ggtaagttct gtccaagc                                                    18

<210>  15162
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15162
ggtaagttct gtccaagc                                                    18

<210>  15163
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15163
ggtaagttct gtccaagc                                                    18

<210>  15164
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15164
ggtaagttct gtccaagc                                                    18

<210>  15165
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15165
ggtaagttct gtccaagc                                                    18

<210>  15166
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15166
ggtaagttct gtccaagc                                                    18

<210>  15167
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15167
ggtaagttct gtccaagc                                                    18

<210>  15168
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15168
ggtaagttct gtccaagc                                                    18

<210>  15169
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15169
ggtaagttct gtccaagc                                                    18

<210>  15170
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15170
ggtaagttct gtccaagc                                                    18

<210>  15171
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15171
gtaagttctg tccaagcc                                                    18

<210>  15172
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15172
gtaagttctg tccaagcc                                                    18

<210>  15173
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15173
gtaagttctg tccaagcc                                                    18

<210>  15174
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15174
gtaagttctg tccaagcc                                                    18

<210>  15175
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15175
gtaagttctg tccaagcc                                                    18

<210>  15176
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15176
gtaagttctg tccaagcc                                                    18

<210>  15177
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15177
gtaagttctg tccaagcc                                                    18

<210>  15178
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15178
gtaagttctg tccaagcc                                                    18

<210>  15179
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15179
gtaagttctg tccaagcc                                                    18

<210>  15180
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15180
gtaagttctg tccaagcc                                                    18

<210>  15181
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15181
gtaagttctg tccaagcc                                                    18

<210>  15182
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15182
gtaagttctg tccaagcc                                                    18

<210>  15183
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15183
gtaagttctg tccaagcc                                                    18

<210>  15184
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15184
gtaagttctg tccaagcc                                                    18

<210>  15185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15185
gtaagttctg tccaagcc                                                    18

<210>  15186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15186
agtcggtaag ttctgtcc                                                    18

<210>  15187
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15187
agtcggtaag ttctgtcc                                                    18

<210>  15188
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15188
agtcggtaag ttctgtcc                                                    18

<210>  15189
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15189
agtcggtaag ttctgtcc                                                    18

<210>  15190
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15190
agtcggtaag ttctgtcc                                                    18

<210>  15191
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15191
agtcggtaag ttctgtcc                                                    18

<210>  15192
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15192
agtcggtaag ttctgtcc                                                    18

<210>  15193
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15193
agtcggtaag ttctgtcc                                                    18

<210>  15194
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15194
agtcggtaag ttctgtcc                                                    18

<210>  15195
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15195
agtcggtaag ttctgtcc                                                    18

<210>  15196
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15196
agtcggtaag ttctgtcc                                                    18

<210>  15197
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15197
agtcggtaag ttctgtcc                                                    18

<210>  15198
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15198
agtcggtaag ttctgtcc                                                    18

<210>  15199
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15199
agtcggtaag ttctgtcc                                                    18

<210>  15200
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15200
agtcggtaag ttctgtcc                                                    18

<210>  15201
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15201
agtcggtaag ttctgtcc                                                    18

<210>  15202
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15202
agtcggtaag ttctgtcc                                                    18

<210>  15203
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15203
agtcggtaag ttctgtcc                                                    18

<210>  15204
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15204
agtcggtaag ttctgtcc                                                    18

<210>  15205
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15205
agtcggtaag ttctgtcc                                                    18

<210>  15206
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15206
agtcggtaag ttctgtcc                                                    18

<210>  15207
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15207
ctgtccaagc ccggttga                                                    18

<210>  15208
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15208
ctgtccaagc ccggttga                                                    18

<210>  15209
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15209
ctgtccaagc ccggttga                                                    18

<210>  15210
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15210
ctgtccaagc ccggttga                                                    18

<210>  15211
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15211
ctgtccaagc ccggttga                                                    18

<210>  15212
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15212
ctgtccaagc ccggttga                                                    18

<210>  15213
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15213
ctgtccaagc ccggttga                                                    18

<210>  15214
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15214
ctgtccaagc ccggttga                                                    18

<210>  15215
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15215
ctgtccaagc ccggttga                                                    18

<210>  15216
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15216
ctgtccaagc ccggttga                                                    18

<210>  15217
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15217
ctgtccaagc ccggttga                                                    18

<210>  15218
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15218
ctgtccaagc ccggttga                                                    18

<210>  15219
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15219
ctgtccaagc ccggttga                                                    18

<210>  15220
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15220
ctgtccaagc ccggttga                                                    18

<210>  15221
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15221
ctgtccaagc ccggttga                                                    18

<210>  15222
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15222
ctgtccaagc ccggttga                                                    18

<210>  15223
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15223
ctgtccaagc ccggttga                                                    18

<210>  15224
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15224
ctgtccaagc ccggttga                                                    18

<210>  15225
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15225
ctgtccaagc ccggttga                                                    18

<210>  15226
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15226
ctgtccaagc ccggttga                                                    18

<210>  15227
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15227
ctgtccaagc ccggttga                                                    18

<210>  15228
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15228
ctgtccaagc ccggttga                                                    18

<210>  15229
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15229
ctgtccaagc ccggttga                                                    18

<210>  15230
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15230
ctgtccaagc ccggttga                                                    18

<210>  15231
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15231
ctgtccaagc ccggttga                                                    18

<210>  15232
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15232
ctgtccaagc ccggttga                                                    18

<210>  15233
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15233
ctgtccaagc ccggttga                                                    18

<210>  15234
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15234
ctgtccaagc ccggttga                                                    18

<210>  15235
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15235
ctgtccaagc ccggttga                                                    18

<210>  15236
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15236
ctgtccaagc ccggttga                                                    18

<210>  15237
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15237
ctgtccaagc ccggttga                                                    18

<210>  15238
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15238
ctgtccaagc ccggttga                                                    18

<210>  15239
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15239
ctgtccaagc ccggttga                                                    18

<210>  15240
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15240
ctgtccaagc ccggttga                                                    18

<210>  15241
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15241
ctgtccaagc ccggttga                                                    18

<210>  15242
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15242
ctgtccaagc ccggttga                                                    18

<210>  15243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15243
tcaaggaaga tggcatttct                                                  20

<210>  15244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15244
tcaaggaaga tggcatttct                                                  20

<210>  15245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15245
tcaaggaaga tggcatttct                                                  20

<210>  15246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15246
tcaaggaaga tggcatttct                                                  20

<210>  15247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15247
tcaaggaaga tggcatttct                                                  20

<210>  15248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15248
tcaaggaaga tggcatttct                                                  20

<210>  15249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15249
tcaaggaaga tggcatttct                                                  20

<210>  15250
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15250
tcaaggaaga tggcatttct ag                                               22

<210>  15251
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15251
tcaaggaaga tggcatttct ag                                               22

<210>  15252
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15252
tcaaggaaga tggcatttct ag                                               22

<210>  15253
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15253
tcaaggaaga tggcatttct ag                                               22

<210>  15254
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15254
tcaaggaaga tggcatttct ag                                               22

<210>  15255
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15255
tcaaggaaga tggcatttct ag                                               22

<210>  15256
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15256
tcaaggaaga tggcatttct ag                                               22

<210>  15257
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15257
tcaaggaaga tggcatttct ag                                               22

<210>  15258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15258
tcaaggaaga tggcatttct                                                  20

<210>  15259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15259
tcaaggaaga tggcatttct                                                  20

<210>  15260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15260
tcaaggaaga tggcatttct                                                  20

<210>  15261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15261
tcaaggaaga tggcatttct                                                  20

<210>  15262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15262
tcaaggaaga tggcatttct                                                  20

<210>  15263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15263
tcaaggaaga tggcatttct                                                  20

<210>  15264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15264
tcaaggaaga tggcatttct                                                  20

<210>  15265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15265
tcaaggaaga tggcatttct                                                  20

<210>  15266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15266
tcaaggaaga tggcatttct                                                  20

<210>  15267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15267
tcaaggaaga tggcatttct                                                  20

<210>  15268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15268
tcaaggaaga tggcatttct                                                  20

<210>  15269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15269
tcaaggaaga tggcatttct                                                  20

<210>  15270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15270
tcaaggaaga tggcatttct                                                  20

<210>  15271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15271
tcaaggaaga tggcatttct                                                  20

<210>  15272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15272
tcaaggaaga tggcatttct                                                  20

<210>  15273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15273
tcaaggaaga tggcatttct                                                  20

<210>  15274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15274
tcaaggaaga tggcatttct                                                  20

<210>  15275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15275
tcaaggaaga tggcatttct                                                  20

<210>  15276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15276
tcaaggaaga tggcatttct                                                  20

<210>  15277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15277
tcaaggaaga tggcatttct                                                  20

<210>  15278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15278
tcaaggaaga tggcatttct                                                  20

<210>  15279
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15279
tcaaggaaga tggcatttct ag                                               22

<210>  15280
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15280
tcaaggaaga tggcatttct ag                                               22

<210>  15281
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15281
tcaaggaaga tggcatttct ag                                               22

<210>  15282
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15282
tcaaggaaga tggcatttct ag                                               22

<210>  15283
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15283
tcaaggaaga tggcatttct ag                                               22

<210>  15284
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15284
tcaaggaaga tggcatttct ag                                               22

<210>  15285
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15285
tcaaggaaga tggcatttct ag                                               22

<210>  15286
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15286
tcaaggaaga tggcatttct ag                                               22

<210>  15287
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15287
tcaaggaaga tggcatttct ag                                               22

<210>  15288
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15288
tcaaggaaga tggcatttct ag                                               22

<210>  15289
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15289
tcaaggaaga tggcatttct ag                                               22

<210>  15290
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15290
tcaaggaaga tggcatttct ag                                               22

<210>  15291
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15291
tcaaggaaga tggcatttct ag                                               22

<210>  15292
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15292
tcaaggaaga tggcatttct ag                                               22

<210>  15293
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15293
tcaaggaaga tggcatttct ag                                               22

<210>  15294
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15294
tcaaggaaga tggcatttct ag                                               22

<210>  15295
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15295
tcaaggaaga tggcatttct ag                                               22

<210>  15296
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15296
tcaaggaaga tggcatttct ag                                               22

<210>  15297
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15297
tcaaggaaga tggcatttct ag                                               22

<210>  15298
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15298
tcaaggaaga tggcatttct ag                                               22

<210>  15299
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15299
tcaaggaaga tggcatttct ag                                               22

<210>  15300
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15300
tcaaggaaga tggcatttct ag                                               22

<210>  15301
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15301
tcaaggaaga tggcatttct ag                                               22

<210>  15302
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15302
tcaaggaaga tggcatttct ag                                               22

<210>  15303
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15303
tcaaggaaga tggcatttct ag                                               22

<210>  15304
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15304
tcaaggaaga tggcatttct ag                                               22

<210>  15305
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15305
tcaaggaaga tggcatttct ag                                               22

<210>  15306
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15306
tcaaggaaga tggcatttct ag                                               22

<210>  15307
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15307
gguaaguucu guccaagc                                                    18

<210>  15308
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15308
gguaaguucu guccaagc                                                    18

<210>  15309
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15309
gguaaguucu guccaagc                                                    18

<210>  15310
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15310
gguaaguucu guccaagc                                                    18

<210>  15311
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15311
gguaaguucu guccaagc                                                    18

<210>  15312
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15312
gtaaguucug uccaagcc                                                    18

<210>  15313
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15313
gtaaguucug uccaagcc                                                    18

<210>  15314
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15314
gtaaguucug uccaagcc                                                    18

<210>  15315
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15315
gtaaguucug uccaagcc                                                    18

<210>  15316
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15316
gtaaguucug uccaagcc                                                    18

<210>  15317
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15317
gtaaguucug uccaagcc                                                    18

<210>  15318
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15318
agucgguaag uucugucc                                                    18

<210>  15319
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15319
agucgguaag uucugucc                                                    18

<210>  15320
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15320
agucgguaag uucugucc                                                    18

<210>  15321
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15321
agucgguaag uucugucc                                                    18

<210>  15322
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15322
agucgguaag uucugucc                                                    18

<210>  15323
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15323
agucgguaag uucugucc                                                    18

<210>  15324
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15324
ctguccaagc ccgguuga                                                    18

<210>  15325
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15325
ctguccaagc ccgguuga                                                    18

<210>  15326
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15326
ctguccaagc ccgguuga                                                    18

<210>  15327
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15327
ctguccaagc ccgguuga                                                    18

<210>  15328
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15328
ctguccaagc ccgguuga                                                    18

<210>  15329
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15329
ctguccaagc ccgguuga                                                    18

<210>  15330
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15330
ctguccaagc ccgguuga                                                    18

<210>  15331
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15331
ctguccaagc ccgguuga                                                    18

<210>  15332
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15332
ctguccaagc ccgguuga                                                    18

<210>  15333
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15333
gguaaguucu guccaagc                                                    18

<210>  15334
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15334
gguaaguucu guccaagc                                                    18

<210>  15335
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15335
gguaaguucu guccaagc                                                    18

<210>  15336
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15336
gguaaguucu guccaagc                                                    18

<210>  15337
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15337
gguaaguucu guccaagc                                                    18

<210>  15338
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15338
gguaaguucu guccaagc                                                    18

<210>  15339
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15339
gguaaguucu guccaagc                                                    18

<210>  15340
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15340
gguaaguucu guccaagc                                                    18

<210>  15341
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15341
gguaaguucu guccaagc                                                    18

<210>  15342
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15342
gguaaguucu guccaagc                                                    18

<210>  15343
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15343
gtaaguucug uccaagcc                                                    18

<210>  15344
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15344
gtaaguucug uccaagcc                                                    18

<210>  15345
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15345
gtaaguucug uccaagcc                                                    18

<210>  15346
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15346
gtaaguucug uccaagcc                                                    18

<210>  15347
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15347
gtaaguucug uccaagcc                                                    18

<210>  15348
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15348
gtaaguucug uccaagcc                                                    18

<210>  15349
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15349
gtaaguucug uccaagcc                                                    18

<210>  15350
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15350
gtaaguucug uccaagcc                                                    18

<210>  15351
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15351
gtaaguucug uccaagcc                                                    18

<210>  15352
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15352
gtaaguucug uccaagcc                                                    18

<210>  15353
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15353
gtaaguucug uccaagcc                                                    18

<210>  15354
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15354
gtaaguucug uccaagcc                                                    18

<210>  15355
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15355
gtaaguucug uccaagcc                                                    18

<210>  15356
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15356
gtaaguucug uccaagcc                                                    18

<210>  15357
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15357
gtaaguucug uccaagcc                                                    18

<210>  15358
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15358
agucgguaag uucugucc                                                    18

<210>  15359
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15359
agucgguaag uucugucc                                                    18

<210>  15360
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15360
agucgguaag uucugucc                                                    18

<210>  15361
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15361
agucgguaag uucugucc                                                    18

<210>  15362
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15362
agucgguaag uucugucc                                                    18

<210>  15363
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15363
agucgguaag uucugucc                                                    18

<210>  15364
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15364
agucgguaag uucugucc                                                    18

<210>  15365
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15365
agucgguaag uucugucc                                                    18

<210>  15366
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15366
agucgguaag uucugucc                                                    18

<210>  15367
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15367
agucgguaag uucugucc                                                    18

<210>  15368
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15368
agucgguaag uucugucc                                                    18

<210>  15369
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15369
agucgguaag uucugucc                                                    18

<210>  15370
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15370
agucgguaag uucugucc                                                    18

<210>  15371
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15371
agucgguaag uucugucc                                                    18

<210>  15372
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15372
agucgguaag uucugucc                                                    18

<210>  15373
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15373
ctguccaagc ccgguuga                                                    18

<210>  15374
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15374
ctguccaagc ccgguuga                                                    18

<210>  15375
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15375
ctguccaagc ccgguuga                                                    18

<210>  15376
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15376
ctguccaagc ccgguuga                                                    18

<210>  15377
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15377
ctguccaagc ccgguuga                                                    18

<210>  15378
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15378
ctguccaagc ccgguuga                                                    18

<210>  15379
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15379
ctguccaagc ccgguuga                                                    18

<210>  15380
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15380
ctguccaagc ccgguuga                                                    18

<210>  15381
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15381
ctguccaagc ccgguuga                                                    18

<210>  15382
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15382
ctguccaagc ccgguuga                                                    18

<210>  15383
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15383
ctguccaagc ccgguuga                                                    18

<210>  15384
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15384
ctguccaagc ccgguuga                                                    18

<210>  15385
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15385
ctguccaagc ccgguuga                                                    18

<210>  15386
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15386
ctguccaagc ccgguuga                                                    18

<210>  15387
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15387
ctguccaagc ccgguuga                                                    18

<210>  15388
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15388
ctguccaagc ccgguuga                                                    18

<210>  15389
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15389
ctguccaagc ccgguuga                                                    18

<210>  15390
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15390
ctguccaagc ccgguuga                                                    18

<210>  15391
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15391
ctguccaagc ccgguuga                                                    18

<210>  15392
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15392
ctguccaagc ccgguuga                                                    18

<210>  15393
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15393
ctguccaagc ccgguuga                                                    18

<210>  15394
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15394
ctguccaagc ccgguuga                                                    18

<210>  15395
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15395
ctguccaagc ccgguuga                                                    18

<210>  15396
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15396
ctguccaagc ccgguuga                                                    18

<210>  15397
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15397
ctguccaagc ccgguuga                                                    18

<210>  15398
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15398
ctguccaagc ccgguuga                                                    18

<210>  15399
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15399
ctguccaagc ccgguuga                                                    18

<210>  15400
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15400
ctguccaagc ccgguuga                                                    18

<210>  15401
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15401
ctguccaagc ccgguuga                                                    18

<210>  15402
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15402
ctguccaagc ccgguuga                                                    18

<210>  15403
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15403
ctguccaagc ccgguuga                                                    18

<210>  15404
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15404
ctguccaagc ccgguuga                                                    18

<210>  15405
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15405
ctguccaagc ccgguuga                                                    18

<210>  15406
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15406
ctguccaagc ccgguuga                                                    18

<210>  15407
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15407
ctguccaagc ccgguuga                                                    18

<210>  15408
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15408
ctguccaagc ccgguuga                                                    18

<210>  15409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15409
tcaaggaaga uggcauuuct                                                  20

<210>  15410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15410
tcaaggaaga uggcauuuct                                                  20

<210>  15411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15411
tcaaggaaga uggcauuuct                                                  20

<210>  15412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15412
tcaaggaaga uggcauuuct                                                  20

<210>  15413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15413
tcaaggaaga uggcauuuct                                                  20

<210>  15414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15414
tcaaggaaga uggcauuuct                                                  20

<210>  15415
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15415
tcaaggaaga uggcauuucu ag                                               22

<210>  15416
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15416
tcaaggaaga uggcauuucu ag                                               22

<210>  15417
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15417
tcaaggaaga uggcauuucu ag                                               22

<210>  15418
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15418
tcaaggaaga uggcauuucu ag                                               22

<210>  15419
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15419
tcaaggaaga uggcauuucu ag                                               22

<210>  15420
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15420
tcaaggaaga uggcauuucu ag                                               22

<210>  15421
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15421
tcaaggaaga uggcauuucu ag                                               22

<210>  15422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15422
tcaaggaaga uggcauuuct                                                  20

<210>  15423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15423
tcaaggaaga uggcauuuct                                                  20

<210>  15424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15424
tcaaggaaga uggcauuuct                                                  20

<210>  15425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15425
tcaaggaaga uggcauuuct                                                  20

<210>  15426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15426
tcaaggaaga uggcauuuct                                                  20

<210>  15427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15427
tcaaggaaga uggcauuuct                                                  20

<210>  15428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15428
tcaaggaaga uggcauuuct                                                  20

<210>  15429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15429
tcaaggaaga uggcauuuct                                                  20

<210>  15430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15430
tcaaggaaga uggcauuuct                                                  20

<210>  15431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15431
tcaaggaaga uggcauuuct                                                  20

<210>  15432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15432
tcaaggaaga uggcauuuct                                                  20

<210>  15433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15433
tcaaggaaga uggcauuuct                                                  20

<210>  15434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15434
tcaaggaaga uggcauuuct                                                  20

<210>  15435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15435
tcaaggaaga uggcauuuct                                                  20

<210>  15436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15436
tcaaggaaga uggcauuuct                                                  20

<210>  15437
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15437
tcaaggaaga uggcauuucu ag                                               22

<210>  15438
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15438
tcaaggaaga uggcauuucu ag                                               22

<210>  15439
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15439
tcaaggaaga uggcauuucu ag                                               22

<210>  15440
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15440
tcaaggaaga uggcauuucu ag                                               22

<210>  15441
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15441
tcaaggaaga uggcauuucu ag                                               22

<210>  15442
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15442
tcaaggaaga uggcauuucu ag                                               22

<210>  15443
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15443
tcaaggaaga uggcauuucu ag                                               22

<210>  15444
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15444
tcaaggaaga uggcauuucu ag                                               22

<210>  15445
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15445
tcaaggaaga uggcauuucu ag                                               22

<210>  15446
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15446
tcaaggaaga uggcauuucu ag                                               22

<210>  15447
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15447
tcaaggaaga uggcauuucu ag                                               22

<210>  15448
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15448
tcaaggaaga uggcauuucu ag                                               22

<210>  15449
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15449
tcaaggaaga uggcauuucu ag                                               22

<210>  15450
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15450
tcaaggaaga uggcauuucu ag                                               22

<210>  15451
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15451
tcaaggaaga uggcauuucu ag                                               22

<210>  15452
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15452
tcaaggaaga uggcauuucu ag                                               22

<210>  15453
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15453
tcaaggaaga uggcauuucu ag                                               22

<210>  15454
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15454
tcaaggaaga uggcauuucu ag                                               22

<210>  15455
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15455
tcaaggaaga uggcauuucu ag                                               22

<210>  15456
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15456
tcaaggaaga uggcauuucu ag                                               22

<210>  15457
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15457
tcaaggaaga uggcauuucu ag                                               22

<210>  15458
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15458
gguaaguucu guccaagc                                                    18

<210>  15459
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15459
gguaaguucu guccaagc                                                    18

<210>  15460
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15460
gguaaguucu guccaagc                                                    18

<210>  15461
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15461
gguaaguucu guccaagc                                                    18

<210>  15462
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15462
gguaaguucu guccaagc                                                    18

<210>  15463
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15463
gtaaguucug uccaagcc                                                    18

<210>  15464
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15464
gtaaguucug uccaagcc                                                    18

<210>  15465
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15465
gtaaguucug uccaagcc                                                    18

<210>  15466
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15466
gtaaguucug uccaagcc                                                    18

<210>  15467
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15467
gtaaguucug uccaagcc                                                    18

<210>  15468
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15468
gtaaguucug uccaagcc                                                    18

<210>  15469
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15469
agucgguaag uucugucc                                                    18

<210>  15470
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15470
agucgguaag uucugucc                                                    18

<210>  15471
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15471
agucgguaag uucugucc                                                    18

<210>  15472
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15472
agucgguaag uucugucc                                                    18

<210>  15473
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15473
agucgguaag uucugucc                                                    18

<210>  15474
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15474
agucgguaag uucugucc                                                    18

<210>  15475
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15475
ctguccaagc ccgguuga                                                    18

<210>  15476
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15476
ctguccaagc ccgguuga                                                    18

<210>  15477
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15477
ctguccaagc ccgguuga                                                    18

<210>  15478
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15478
ctguccaagc ccgguuga                                                    18

<210>  15479
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15479
ctguccaagc ccgguuga                                                    18

<210>  15480
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15480
ctguccaagc ccgguuga                                                    18

<210>  15481
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15481
ctguccaagc ccgguuga                                                    18

<210>  15482
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15482
ctguccaagc ccgguuga                                                    18

<210>  15483
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15483
ctguccaagc ccgguuga                                                    18

<210>  15484
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15484
gguaaguucu guccaagc                                                    18

<210>  15485
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15485
gguaaguucu guccaagc                                                    18

<210>  15486
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15486
gguaaguucu guccaagc                                                    18

<210>  15487
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15487
gguaaguucu guccaagc                                                    18

<210>  15488
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15488
gguaaguucu guccaagc                                                    18

<210>  15489
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15489
gguaaguucu guccaagc                                                    18

<210>  15490
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15490
gguaaguucu guccaagc                                                    18

<210>  15491
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15491
gguaaguucu guccaagc                                                    18

<210>  15492
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15492
gguaaguucu guccaagc                                                    18

<210>  15493
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15493
gguaaguucu guccaagc                                                    18

<210>  15494
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15494
gtaaguucug uccaagcc                                                    18

<210>  15495
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15495
gtaaguucug uccaagcc                                                    18

<210>  15496
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15496
gtaaguucug uccaagcc                                                    18

<210>  15497
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15497
gtaaguucug uccaagcc                                                    18

<210>  15498
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15498
gtaaguucug uccaagcc                                                    18

<210>  15499
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15499
gtaaguucug uccaagcc                                                    18

<210>  15500
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15500
gtaaguucug uccaagcc                                                    18

<210>  15501
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15501
gtaaguucug uccaagcc                                                    18

<210>  15502
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15502
gtaaguucug uccaagcc                                                    18

<210>  15503
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15503
gtaaguucug uccaagcc                                                    18

<210>  15504
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15504
gtaaguucug uccaagcc                                                    18

<210>  15505
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15505
gtaaguucug uccaagcc                                                    18

<210>  15506
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15506
gtaaguucug uccaagcc                                                    18

<210>  15507
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15507
gtaaguucug uccaagcc                                                    18

<210>  15508
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15508
gtaaguucug uccaagcc                                                    18

<210>  15509
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15509
agucgguaag uucugucc                                                    18

<210>  15510
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15510
agucgguaag uucugucc                                                    18

<210>  15511
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15511
agucgguaag uucugucc                                                    18

<210>  15512
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15512
agucgguaag uucugucc                                                    18

<210>  15513
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15513
agucgguaag uucugucc                                                    18

<210>  15514
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15514
agucgguaag uucugucc                                                    18

<210>  15515
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15515
agucgguaag uucugucc                                                    18

<210>  15516
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15516
agucgguaag uucugucc                                                    18

<210>  15517
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15517
agucgguaag uucugucc                                                    18

<210>  15518
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15518
agucgguaag uucugucc                                                    18

<210>  15519
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15519
agucgguaag uucugucc                                                    18

<210>  15520
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15520
agucgguaag uucugucc                                                    18

<210>  15521
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15521
agucgguaag uucugucc                                                    18

<210>  15522
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15522
agucgguaag uucugucc                                                    18

<210>  15523
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15523
agucgguaag uucugucc                                                    18

<210>  15524
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15524
ctguccaagc ccgguuga                                                    18

<210>  15525
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15525
ctguccaagc ccgguuga                                                    18

<210>  15526
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15526
ctguccaagc ccgguuga                                                    18

<210>  15527
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15527
ctguccaagc ccgguuga                                                    18

<210>  15528
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15528
ctguccaagc ccgguuga                                                    18

<210>  15529
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15529
ctguccaagc ccgguuga                                                    18

<210>  15530
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15530
ctguccaagc ccgguuga                                                    18

<210>  15531
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15531
ctguccaagc ccgguuga                                                    18

<210>  15532
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15532
ctguccaagc ccgguuga                                                    18

<210>  15533
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15533
ctguccaagc ccgguuga                                                    18

<210>  15534
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15534
ctguccaagc ccgguuga                                                    18

<210>  15535
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15535
ctguccaagc ccgguuga                                                    18

<210>  15536
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15536
ctguccaagc ccgguuga                                                    18

<210>  15537
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15537
ctguccaagc ccgguuga                                                    18

<210>  15538
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15538
ctguccaagc ccgguuga                                                    18

<210>  15539
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15539
ctguccaagc ccgguuga                                                    18

<210>  15540
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15540
ctguccaagc ccgguuga                                                    18

<210>  15541
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15541
ctguccaagc ccgguuga                                                    18

<210>  15542
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15542
ctguccaagc ccgguuga                                                    18

<210>  15543
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15543
ctguccaagc ccgguuga                                                    18

<210>  15544
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15544
ctguccaagc ccgguuga                                                    18

<210>  15545
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15545
ctguccaagc ccgguuga                                                    18

<210>  15546
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15546
ctguccaagc ccgguuga                                                    18

<210>  15547
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15547
ctguccaagc ccgguuga                                                    18

<210>  15548
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15548
ctguccaagc ccgguuga                                                    18

<210>  15549
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15549
ctguccaagc ccgguuga                                                    18

<210>  15550
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15550
ctguccaagc ccgguuga                                                    18

<210>  15551
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15551
ctguccaagc ccgguuga                                                    18

<210>  15552
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15552
ctguccaagc ccgguuga                                                    18

<210>  15553
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15553
ctguccaagc ccgguuga                                                    18

<210>  15554
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15554
ctguccaagc ccgguuga                                                    18

<210>  15555
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15555
ctguccaagc ccgguuga                                                    18

<210>  15556
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15556
ctguccaagc ccgguuga                                                    18

<210>  15557
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15557
ctguccaagc ccgguuga                                                    18

<210>  15558
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15558
ctguccaagc ccgguuga                                                    18

<210>  15559
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15559
ctguccaagc ccgguuga                                                    18

<210>  15560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15560
tcaaggaaga uggcauuuct                                                  20

<210>  15561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15561
tcaaggaaga uggcauuuct                                                  20

<210>  15562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15562
tcaaggaaga uggcauuuct                                                  20

<210>  15563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15563
tcaaggaaga uggcauuuct                                                  20

<210>  15564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15564
tcaaggaaga uggcauuuct                                                  20

<210>  15565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15565
tcaaggaaga uggcauuuct                                                  20

<210>  15566
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15566
tcaaggaaga uggcauuucu ag                                               22

<210>  15567
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15567
tcaaggaaga uggcauuucu ag                                               22

<210>  15568
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15568
tcaaggaaga uggcauuucu ag                                               22

<210>  15569
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15569
tcaaggaaga uggcauuucu ag                                               22

<210>  15570
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15570
tcaaggaaga uggcauuucu ag                                               22

<210>  15571
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15571
tcaaggaaga uggcauuucu ag                                               22

<210>  15572
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15572
tcaaggaaga uggcauuucu ag                                               22

<210>  15573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15573
tcaaggaaga uggcauuuct                                                  20

<210>  15574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15574
tcaaggaaga uggcauuuct                                                  20

<210>  15575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15575
tcaaggaaga uggcauuuct                                                  20

<210>  15576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15576
tcaaggaaga uggcauuuct                                                  20

<210>  15577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15577
tcaaggaaga uggcauuuct                                                  20

<210>  15578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15578
tcaaggaaga uggcauuuct                                                  20

<210>  15579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15579
tcaaggaaga uggcauuuct                                                  20

<210>  15580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15580
tcaaggaaga uggcauuuct                                                  20

<210>  15581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15581
tcaaggaaga uggcauuuct                                                  20

<210>  15582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15582
tcaaggaaga uggcauuuct                                                  20

<210>  15583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15583
tcaaggaaga uggcauuuct                                                  20

<210>  15584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15584
tcaaggaaga uggcauuuct                                                  20

<210>  15585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15585
tcaaggaaga uggcauuuct                                                  20

<210>  15586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15586
tcaaggaaga uggcauuuct                                                  20

<210>  15587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15587
tcaaggaaga uggcauuuct                                                  20

<210>  15588
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15588
tcaaggaaga uggcauuucu ag                                               22

<210>  15589
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15589
tcaaggaaga uggcauuucu ag                                               22

<210>  15590
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15590
tcaaggaaga uggcauuucu ag                                               22

<210>  15591
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15591
tcaaggaaga uggcauuucu ag                                               22

<210>  15592
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15592
tcaaggaaga uggcauuucu ag                                               22

<210>  15593
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15593
tcaaggaaga uggcauuucu ag                                               22

<210>  15594
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15594
tcaaggaaga uggcauuucu ag                                               22

<210>  15595
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15595
tcaaggaaga uggcauuucu ag                                               22

<210>  15596
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15596
tcaaggaaga uggcauuucu ag                                               22

<210>  15597
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15597
tcaaggaaga uggcauuucu ag                                               22

<210>  15598
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15598
tcaaggaaga uggcauuucu ag                                               22

<210>  15599
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15599
tcaaggaaga uggcauuucu ag                                               22

<210>  15600
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15600
tcaaggaaga uggcauuucu ag                                               22

<210>  15601
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15601
tcaaggaaga uggcauuucu ag                                               22

<210>  15602
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15602
tcaaggaaga uggcauuucu ag                                               22

<210>  15603
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15603
tcaaggaaga uggcauuucu ag                                               22

<210>  15604
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15604
tcaaggaaga uggcauuucu ag                                               22

<210>  15605
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15605
tcaaggaaga uggcauuucu ag                                               22

<210>  15606
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15606
tcaaggaaga uggcauuucu ag                                               22

<210>  15607
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15607
tcaaggaaga uggcauuucu ag                                               22

<210>  15608
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15608
tcaaggaaga uggcauuucu ag                                               22

<210>  15609
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15609
ggtaagttct gtccaagc                                                    18

<210>  15610
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15610
ggtaagttct gtccaagc                                                    18

<210>  15611
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15611
ggtaagttct gtccaagc                                                    18

<210>  15612
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15612
ggtaagttct gtccaagc                                                    18

<210>  15613
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15613
ggtaagttct gtccaagc                                                    18

<210>  15614
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15614
gtaagttctg tccaagcc                                                    18

<210>  15615
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15615
gtaagttctg tccaagcc                                                    18

<210>  15616
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15616
gtaagttctg tccaagcc                                                    18

<210>  15617
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15617
gtaagttctg tccaagcc                                                    18

<210>  15618
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15618
gtaagttctg tccaagcc                                                    18

<210>  15619
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15619
gtaagttctg tccaagcc                                                    18

<210>  15620
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15620
agtcggtaag ttctgtcc                                                    18

<210>  15621
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15621
agtcggtaag ttctgtcc                                                    18

<210>  15622
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15622
agtcggtaag ttctgtcc                                                    18

<210>  15623
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15623
agtcggtaag ttctgtcc                                                    18

<210>  15624
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15624
agtcggtaag ttctgtcc                                                    18

<210>  15625
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15625
agtcggtaag ttctgtcc                                                    18

<210>  15626
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15626
ctgtccaagc ccggttga                                                    18

<210>  15627
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15627
ctgtccaagc ccggttga                                                    18

<210>  15628
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15628
ctgtccaagc ccggttga                                                    18

<210>  15629
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15629
ctgtccaagc ccggttga                                                    18

<210>  15630
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15630
ctgtccaagc ccggttga                                                    18

<210>  15631
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15631
ctgtccaagc ccggttga                                                    18

<210>  15632
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15632
ctgtccaagc ccggttga                                                    18

<210>  15633
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15633
ctgtccaagc ccggttga                                                    18

<210>  15634
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15634
ctgtccaagc ccggttga                                                    18

<210>  15635
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15635
ggtaagttct gtccaagc                                                    18

<210>  15636
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15636
ggtaagttct gtccaagc                                                    18

<210>  15637
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15637
ggtaagttct gtccaagc                                                    18

<210>  15638
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15638
ggtaagttct gtccaagc                                                    18

<210>  15639
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15639
ggtaagttct gtccaagc                                                    18

<210>  15640
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15640
ggtaagttct gtccaagc                                                    18

<210>  15641
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15641
ggtaagttct gtccaagc                                                    18

<210>  15642
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15642
ggtaagttct gtccaagc                                                    18

<210>  15643
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15643
ggtaagttct gtccaagc                                                    18

<210>  15644
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15644
ggtaagttct gtccaagc                                                    18

<210>  15645
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15645
gtaagttctg tccaagcc                                                    18

<210>  15646
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15646
gtaagttctg tccaagcc                                                    18

<210>  15647
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15647
gtaagttctg tccaagcc                                                    18

<210>  15648
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15648
gtaagttctg tccaagcc                                                    18

<210>  15649
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15649
gtaagttctg tccaagcc                                                    18

<210>  15650
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15650
gtaagttctg tccaagcc                                                    18

<210>  15651
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15651
gtaagttctg tccaagcc                                                    18

<210>  15652
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15652
gtaagttctg tccaagcc                                                    18

<210>  15653
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15653
gtaagttctg tccaagcc                                                    18

<210>  15654
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15654
gtaagttctg tccaagcc                                                    18

<210>  15655
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15655
gtaagttctg tccaagcc                                                    18

<210>  15656
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15656
gtaagttctg tccaagcc                                                    18

<210>  15657
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15657
gtaagttctg tccaagcc                                                    18

<210>  15658
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15658
gtaagttctg tccaagcc                                                    18

<210>  15659
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15659
gtaagttctg tccaagcc                                                    18

<210>  15660
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15660
agtcggtaag ttctgtcc                                                    18

<210>  15661
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15661
agtcggtaag ttctgtcc                                                    18

<210>  15662
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15662
agtcggtaag ttctgtcc                                                    18

<210>  15663
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15663
agtcggtaag ttctgtcc                                                    18

<210>  15664
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15664
agtcggtaag ttctgtcc                                                    18

<210>  15665
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15665
agtcggtaag ttctgtcc                                                    18

<210>  15666
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15666
agtcggtaag ttctgtcc                                                    18

<210>  15667
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15667
agtcggtaag ttctgtcc                                                    18

<210>  15668
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15668
agtcggtaag ttctgtcc                                                    18

<210>  15669
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15669
agtcggtaag ttctgtcc                                                    18

<210>  15670
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15670
agtcggtaag ttctgtcc                                                    18

<210>  15671
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15671
agtcggtaag ttctgtcc                                                    18

<210>  15672
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15672
agtcggtaag ttctgtcc                                                    18

<210>  15673
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15673
agtcggtaag ttctgtcc                                                    18

<210>  15674
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15674
agtcggtaag ttctgtcc                                                    18

<210>  15675
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15675
ctgtccaagc ccggttga                                                    18

<210>  15676
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15676
ctgtccaagc ccggttga                                                    18

<210>  15677
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15677
ctgtccaagc ccggttga                                                    18

<210>  15678
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15678
ctgtccaagc ccggttga                                                    18

<210>  15679
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15679
ctgtccaagc ccggttga                                                    18

<210>  15680
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15680
ctgtccaagc ccggttga                                                    18

<210>  15681
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15681
ctgtccaagc ccggttga                                                    18

<210>  15682
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15682
ctgtccaagc ccggttga                                                    18

<210>  15683
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15683
ctgtccaagc ccggttga                                                    18

<210>  15684
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15684
ctgtccaagc ccggttga                                                    18

<210>  15685
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15685
ctgtccaagc ccggttga                                                    18

<210>  15686
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15686
ctgtccaagc ccggttga                                                    18

<210>  15687
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15687
ctgtccaagc ccggttga                                                    18

<210>  15688
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15688
ctgtccaagc ccggttga                                                    18

<210>  15689
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15689
ctgtccaagc ccggttga                                                    18

<210>  15690
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15690
ctgtccaagc ccggttga                                                    18

<210>  15691
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15691
ctgtccaagc ccggttga                                                    18

<210>  15692
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15692
ctgtccaagc ccggttga                                                    18

<210>  15693
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15693
ctgtccaagc ccggttga                                                    18

<210>  15694
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15694
ctgtccaagc ccggttga                                                    18

<210>  15695
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15695
ctgtccaagc ccggttga                                                    18

<210>  15696
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15696
ctgtccaagc ccggttga                                                    18

<210>  15697
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15697
ctgtccaagc ccggttga                                                    18

<210>  15698
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15698
ctgtccaagc ccggttga                                                    18

<210>  15699
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15699
ctgtccaagc ccggttga                                                    18

<210>  15700
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15700
ctgtccaagc ccggttga                                                    18

<210>  15701
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15701
ctgtccaagc ccggttga                                                    18

<210>  15702
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15702
ctgtccaagc ccggttga                                                    18

<210>  15703
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15703
ctgtccaagc ccggttga                                                    18

<210>  15704
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15704
ctgtccaagc ccggttga                                                    18

<210>  15705
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15705
ctgtccaagc ccggttga                                                    18

<210>  15706
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15706
ctgtccaagc ccggttga                                                    18

<210>  15707
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15707
ctgtccaagc ccggttga                                                    18

<210>  15708
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15708
ctgtccaagc ccggttga                                                    18

<210>  15709
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15709
ctgtccaagc ccggttga                                                    18

<210>  15710
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15710
ctgtccaagc ccggttga                                                    18

<210>  15711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15711
tcaaggaaga tggcatttct                                                  20

<210>  15712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15712
tcaaggaaga tggcatttct                                                  20

<210>  15713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15713
tcaaggaaga tggcatttct                                                  20

<210>  15714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15714
tcaaggaaga tggcatttct                                                  20

<210>  15715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15715
tcaaggaaga tggcatttct                                                  20

<210>  15716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15716
tcaaggaaga tggcatttct                                                  20

<210>  15717
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15717
tcaaggaaga tggcatttct ag                                               22

<210>  15718
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15718
tcaaggaaga tggcatttct ag                                               22

<210>  15719
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15719
tcaaggaaga tggcatttct ag                                               22

<210>  15720
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15720
tcaaggaaga tggcatttct ag                                               22

<210>  15721
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15721
tcaaggaaga tggcatttct ag                                               22

<210>  15722
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15722
tcaaggaaga tggcatttct ag                                               22

<210>  15723
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15723
tcaaggaaga tggcatttct ag                                               22

<210>  15724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15724
tcaaggaaga tggcatttct                                                  20

<210>  15725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15725
tcaaggaaga tggcatttct                                                  20

<210>  15726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15726
tcaaggaaga tggcatttct                                                  20

<210>  15727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15727
tcaaggaaga tggcatttct                                                  20

<210>  15728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15728
tcaaggaaga tggcatttct                                                  20

<210>  15729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15729
tcaaggaaga tggcatttct                                                  20

<210>  15730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15730
tcaaggaaga tggcatttct                                                  20

<210>  15731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15731
tcaaggaaga tggcatttct                                                  20

<210>  15732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15732
tcaaggaaga tggcatttct                                                  20

<210>  15733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15733
tcaaggaaga tggcatttct                                                  20

<210>  15734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15734
tcaaggaaga tggcatttct                                                  20

<210>  15735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15735
tcaaggaaga tggcatttct                                                  20

<210>  15736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15736
tcaaggaaga tggcatttct                                                  20

<210>  15737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15737
tcaaggaaga tggcatttct                                                  20

<210>  15738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15738
tcaaggaaga tggcatttct                                                  20

<210>  15739
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15739
tcaaggaaga tggcatttct ag                                               22

<210>  15740
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15740
tcaaggaaga tggcatttct ag                                               22

<210>  15741
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15741
tcaaggaaga tggcatttct ag                                               22

<210>  15742
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15742
tcaaggaaga tggcatttct ag                                               22

<210>  15743
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15743
tcaaggaaga tggcatttct ag                                               22

<210>  15744
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15744
tcaaggaaga tggcatttct ag                                               22

<210>  15745
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15745
tcaaggaaga tggcatttct ag                                               22

<210>  15746
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15746
tcaaggaaga tggcatttct ag                                               22

<210>  15747
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15747
tcaaggaaga tggcatttct ag                                               22

<210>  15748
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15748
tcaaggaaga tggcatttct ag                                               22

<210>  15749
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15749
tcaaggaaga tggcatttct ag                                               22

<210>  15750
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15750
tcaaggaaga tggcatttct ag                                               22

<210>  15751
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15751
tcaaggaaga tggcatttct ag                                               22

<210>  15752
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15752
tcaaggaaga tggcatttct ag                                               22

<210>  15753
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15753
tcaaggaaga tggcatttct ag                                               22

<210>  15754
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15754
tcaaggaaga tggcatttct ag                                               22

<210>  15755
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15755
tcaaggaaga tggcatttct ag                                               22

<210>  15756
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15756
tcaaggaaga tggcatttct ag                                               22

<210>  15757
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15757
tcaaggaaga tggcatttct ag                                               22

<210>  15758
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15758
tcaaggaaga tggcatttct ag                                               22

<210>  15759
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15759
tcaaggaaga tggcatttct ag                                               22

<210>  15760
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15760
ggtaagttct gtccaagc                                                    18

<210>  15761
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15761
ggtaagttct gtccaagc                                                    18

<210>  15762
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15762
ggtaagttct gtccaagc                                                    18

<210>  15763
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15763
ggtaagttct gtccaagc                                                    18

<210>  15764
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15764
ggtaagttct gtccaagc                                                    18

<210>  15765
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15765
gtaagttctg tccaagcc                                                    18

<210>  15766
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15766
gtaagttctg tccaagcc                                                    18

<210>  15767
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15767
gtaagttctg tccaagcc                                                    18

<210>  15768
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15768
gtaagttctg tccaagcc                                                    18

<210>  15769
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15769
gtaagttctg tccaagcc                                                    18

<210>  15770
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15770
gtaagttctg tccaagcc                                                    18

<210>  15771
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15771
agtcggtaag ttctgtcc                                                    18

<210>  15772
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15772
agtcggtaag ttctgtcc                                                    18

<210>  15773
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15773
agtcggtaag ttctgtcc                                                    18

<210>  15774
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15774
agtcggtaag ttctgtcc                                                    18

<210>  15775
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15775
agtcggtaag ttctgtcc                                                    18

<210>  15776
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15776
agtcggtaag ttctgtcc                                                    18

<210>  15777
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15777
ctgtccaagc ccggttga                                                    18

<210>  15778
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15778
ctgtccaagc ccggttga                                                    18

<210>  15779
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15779
ctgtccaagc ccggttga                                                    18

<210>  15780
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15780
ctgtccaagc ccggttga                                                    18

<210>  15781
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15781
ctgtccaagc ccggttga                                                    18

<210>  15782
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15782
ctgtccaagc ccggttga                                                    18

<210>  15783
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15783
ctgtccaagc ccggttga                                                    18

<210>  15784
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15784
ctgtccaagc ccggttga                                                    18

<210>  15785
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15785
ctgtccaagc ccggttga                                                    18

<210>  15786
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15786
ggtaagttct gtccaagc                                                    18

<210>  15787
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15787
ggtaagttct gtccaagc                                                    18

<210>  15788
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15788
ggtaagttct gtccaagc                                                    18

<210>  15789
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15789
ggtaagttct gtccaagc                                                    18

<210>  15790
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15790
ggtaagttct gtccaagc                                                    18

<210>  15791
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15791
ggtaagttct gtccaagc                                                    18

<210>  15792
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15792
ggtaagttct gtccaagc                                                    18

<210>  15793
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15793
ggtaagttct gtccaagc                                                    18

<210>  15794
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15794
ggtaagttct gtccaagc                                                    18

<210>  15795
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15795
ggtaagttct gtccaagc                                                    18

<210>  15796
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15796
gtaagttctg tccaagcc                                                    18

<210>  15797
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15797
gtaagttctg tccaagcc                                                    18

<210>  15798
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15798
gtaagttctg tccaagcc                                                    18

<210>  15799
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15799
gtaagttctg tccaagcc                                                    18

<210>  15800
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15800
gtaagttctg tccaagcc                                                    18

<210>  15801
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15801
gtaagttctg tccaagcc                                                    18

<210>  15802
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15802
gtaagttctg tccaagcc                                                    18

<210>  15803
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15803
gtaagttctg tccaagcc                                                    18

<210>  15804
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15804
gtaagttctg tccaagcc                                                    18

<210>  15805
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15805
gtaagttctg tccaagcc                                                    18

<210>  15806
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15806
gtaagttctg tccaagcc                                                    18

<210>  15807
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15807
gtaagttctg tccaagcc                                                    18

<210>  15808
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15808
gtaagttctg tccaagcc                                                    18

<210>  15809
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15809
gtaagttctg tccaagcc                                                    18

<210>  15810
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15810
gtaagttctg tccaagcc                                                    18

<210>  15811
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15811
agtcggtaag ttctgtcc                                                    18

<210>  15812
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15812
agtcggtaag ttctgtcc                                                    18

<210>  15813
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15813
agtcggtaag ttctgtcc                                                    18

<210>  15814
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15814
agtcggtaag ttctgtcc                                                    18

<210>  15815
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15815
agtcggtaag ttctgtcc                                                    18

<210>  15816
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15816
agtcggtaag ttctgtcc                                                    18

<210>  15817
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15817
agtcggtaag ttctgtcc                                                    18

<210>  15818
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15818
agtcggtaag ttctgtcc                                                    18

<210>  15819
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15819
agtcggtaag ttctgtcc                                                    18

<210>  15820
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15820
agtcggtaag ttctgtcc                                                    18

<210>  15821
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15821
agtcggtaag ttctgtcc                                                    18

<210>  15822
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15822
agtcggtaag ttctgtcc                                                    18

<210>  15823
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15823
agtcggtaag ttctgtcc                                                    18

<210>  15824
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15824
agtcggtaag ttctgtcc                                                    18

<210>  15825
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15825
agtcggtaag ttctgtcc                                                    18

<210>  15826
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15826
ctgtccaagc ccggttga                                                    18

<210>  15827
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15827
ctgtccaagc ccggttga                                                    18

<210>  15828
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15828
ctgtccaagc ccggttga                                                    18

<210>  15829
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15829
ctgtccaagc ccggttga                                                    18

<210>  15830
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15830
ctgtccaagc ccggttga                                                    18

<210>  15831
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15831
ctgtccaagc ccggttga                                                    18

<210>  15832
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15832
ctgtccaagc ccggttga                                                    18

<210>  15833
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15833
ctgtccaagc ccggttga                                                    18

<210>  15834
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15834
ctgtccaagc ccggttga                                                    18

<210>  15835
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15835
ctgtccaagc ccggttga                                                    18

<210>  15836
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15836
ctgtccaagc ccggttga                                                    18

<210>  15837
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15837
ctgtccaagc ccggttga                                                    18

<210>  15838
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15838
ctgtccaagc ccggttga                                                    18

<210>  15839
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15839
ctgtccaagc ccggttga                                                    18

<210>  15840
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15840
ctgtccaagc ccggttga                                                    18

<210>  15841
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15841
ctgtccaagc ccggttga                                                    18

<210>  15842
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15842
ctgtccaagc ccggttga                                                    18

<210>  15843
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15843
ctgtccaagc ccggttga                                                    18

<210>  15844
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15844
ctgtccaagc ccggttga                                                    18

<210>  15845
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15845
ctgtccaagc ccggttga                                                    18

<210>  15846
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15846
ctgtccaagc ccggttga                                                    18

<210>  15847
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15847
ctgtccaagc ccggttga                                                    18

<210>  15848
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15848
ctgtccaagc ccggttga                                                    18

<210>  15849
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15849
ctgtccaagc ccggttga                                                    18

<210>  15850
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15850
ctgtccaagc ccggttga                                                    18

<210>  15851
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15851
ctgtccaagc ccggttga                                                    18

<210>  15852
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15852
ctgtccaagc ccggttga                                                    18

<210>  15853
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15853
ctgtccaagc ccggttga                                                    18

<210>  15854
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15854
ctgtccaagc ccggttga                                                    18

<210>  15855
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15855
ctgtccaagc ccggttga                                                    18

<210>  15856
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15856
ctgtccaagc ccggttga                                                    18

<210>  15857
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15857
ctgtccaagc ccggttga                                                    18

<210>  15858
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15858
ctgtccaagc ccggttga                                                    18

<210>  15859
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15859
ctgtccaagc ccggttga                                                    18

<210>  15860
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15860
ctgtccaagc ccggttga                                                    18

<210>  15861
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15861
ctgtccaagc ccggttga                                                    18

<210>  15862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15862
tcaaggaaga tggcatttct                                                  20

<210>  15863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15863
tcaaggaaga tggcatttct                                                  20

<210>  15864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15864
tcaaggaaga tggcatttct                                                  20

<210>  15865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15865
tcaaggaaga tggcatttct                                                  20

<210>  15866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15866
tcaaggaaga tggcatttct                                                  20

<210>  15867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15867
tcaaggaaga tggcatttct                                                  20

<210>  15868
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15868
tcaaggaaga tggcatttct ag                                               22

<210>  15869
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15869
tcaaggaaga tggcatttct ag                                               22

<210>  15870
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15870
tcaaggaaga tggcatttct ag                                               22

<210>  15871
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15871
tcaaggaaga tggcatttct ag                                               22

<210>  15872
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15872
tcaaggaaga tggcatttct ag                                               22

<210>  15873
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15873
tcaaggaaga tggcatttct ag                                               22

<210>  15874
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15874
tcaaggaaga tggcatttct ag                                               22

<210>  15875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15875
tcaaggaaga tggcatttct                                                  20

<210>  15876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15876
tcaaggaaga tggcatttct                                                  20

<210>  15877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15877
tcaaggaaga tggcatttct                                                  20

<210>  15878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15878
tcaaggaaga tggcatttct                                                  20

<210>  15879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15879
tcaaggaaga tggcatttct                                                  20

<210>  15880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15880
tcaaggaaga tggcatttct                                                  20

<210>  15881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15881
tcaaggaaga tggcatttct                                                  20

<210>  15882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15882
tcaaggaaga tggcatttct                                                  20

<210>  15883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15883
tcaaggaaga tggcatttct                                                  20

<210>  15884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15884
tcaaggaaga tggcatttct                                                  20

<210>  15885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15885
tcaaggaaga tggcatttct                                                  20

<210>  15886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15886
tcaaggaaga tggcatttct                                                  20

<210>  15887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15887
tcaaggaaga tggcatttct                                                  20

<210>  15888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15888
tcaaggaaga tggcatttct                                                  20

<210>  15889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15889
tcaaggaaga tggcatttct                                                  20

<210>  15890
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15890
tcaaggaaga tggcatttct ag                                               22

<210>  15891
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15891
tcaaggaaga tggcatttct ag                                               22

<210>  15892
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15892
tcaaggaaga tggcatttct ag                                               22

<210>  15893
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15893
tcaaggaaga tggcatttct ag                                               22

<210>  15894
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15894
tcaaggaaga tggcatttct ag                                               22

<210>  15895
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15895
tcaaggaaga tggcatttct ag                                               22

<210>  15896
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15896
tcaaggaaga tggcatttct ag                                               22

<210>  15897
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15897
tcaaggaaga tggcatttct ag                                               22

<210>  15898
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15898
tcaaggaaga tggcatttct ag                                               22

<210>  15899
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15899
tcaaggaaga tggcatttct ag                                               22

<210>  15900
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15900
tcaaggaaga tggcatttct ag                                               22

<210>  15901
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15901
tcaaggaaga tggcatttct ag                                               22

<210>  15902
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15902
tcaaggaaga tggcatttct ag                                               22

<210>  15903
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15903
tcaaggaaga tggcatttct ag                                               22

<210>  15904
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15904
tcaaggaaga tggcatttct ag                                               22

<210>  15905
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15905
tcaaggaaga tggcatttct ag                                               22

<210>  15906
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15906
tcaaggaaga tggcatttct ag                                               22

<210>  15907
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15907
tcaaggaaga tggcatttct ag                                               22

<210>  15908
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15908
tcaaggaaga tggcatttct ag                                               22

<210>  15909
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15909
tcaaggaaga tggcatttct ag                                               22

<210>  15910
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  15910
tcaaggaaga tggcatttct ag                                               22

<210>  15911
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15911
gguaaguucu guccaagc                                                    18

<210>  15912
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15912
gguaaguuct guccaagc                                                    18

<210>  15913
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15913
gguaaguucu guccaagc                                                    18

<210>  15914
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15914
gguaaguucu guccaagc                                                    18

<210>  15915
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15915
gguaaguucu guccaagc                                                    18

<210>  15916
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15916
gguaaguucu guccaagc                                                    18

<210>  15917
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15917
gguaaguucu guccaagc                                                    18

<210>  15918
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15918
gguaaguucu guccaagc                                                    18

<210>  15919
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15919
gguaaguucu guccaagc                                                    18

<210>  15920
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15920
gguaaguucu guccaagc                                                    18

<210>  15921
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15921
gguaaguucu guccaagc                                                    18

<210>  15922
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15922
gguaaguucu guccaagc                                                    18

<210>  15923
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15923
guaaguucug uccaagcc                                                    18

<210>  15924
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15924
guaaguucug uccaagcc                                                    18

<210>  15925
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15925
agucgguaag uucugucc                                                    18

<210>  15926
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15926
agucgguaag uucugucc                                                    18

<210>  15927
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15927
agucgguaag uucugucc                                                    18

<210>  15928
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15928
agucgguaag uucugucc                                                    18

<210>  15929
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15929
agucgguaag uucugucc                                                    18

<210>  15930
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15930
agucgguaag uucugucc                                                    18

<210>  15931
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15931
agucgguaag uucugucc                                                    18

<210>  15932
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15932
agucgguaag uucugucc                                                    18

<210>  15933
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15933
agucgguaag uucugucc                                                    18

<210>  15934
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15934
agucgguaag uucugucc                                                    18

<210>  15935
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15935
cuguccaagc ccgguuga                                                    18

<210>  15936
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15936
cuguccaagc ccgguuga                                                    18

<210>  15937
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15937
cuguccaagc ccgguuga                                                    18

<210>  15938
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15938
cuguccaagc ccgguuga                                                    18

<210>  15939
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15939
cuguccaagc ccgguuga                                                    18

<210>  15940
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15940
cuguccaagc ccgguuga                                                    18

<210>  15941
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15941
cuguccaagc ccgguuga                                                    18

<210>  15942
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15942
cuguccaagc ccgguuga                                                    18

<210>  15943
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15943
cuguccaagc ccgguuga                                                    18

<210>  15944
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15944
cuguccaagc ccgguuga                                                    18

<210>  15945
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  15945
cuguccaagc ccgguuga                                                    18

<210>  15946
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  15946
taaguucugu ccaag                                                       15

<210>  15947
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  15947
taaguucugu ccaag                                                       15

<210>  15948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  15948
tcaaggaaga uggcauuucu                                                  20

<210>  15949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  15949
ucaaggaaga uggcauuucu                                                  20

<210>  15950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15950
tcaaggaaga uggcauuuct                                                  20

<210>  15951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  15951
tcaaggaaga uggcauuucu                                                  20

<210>  15952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  15952
tcaaggaaga uggcauuucu                                                  20

<210>  15953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15953
tcaaggaaga uggcauuuct                                                  20

<210>  15954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15954
tcaaggaaga uggcauuuct                                                  20

<210>  15955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15955
tcaaggaaga uggcauuuct                                                  20

<210>  15956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15956
tcaaggaaga uggcauuuct                                                  20

<210>  15957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15957
tcaaggaaga tggcauuuct                                                  20

<210>  15958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15958
tcaaggaaga uggcauuuct                                                  20

<210>  15959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15959
tcaaggaaga uggcauuuct                                                  20

<210>  15960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15960
tcaaggaaga uggcauuuct                                                  20

<210>  15961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15961
tcaaggaaga uggcauuuct                                                  20

<210>  15962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  15962
tcaaggaaga uggcauuuct                                                  20

<210>  15963
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  15963
tcaaggaaga uggcauuucu ag                                               22

<210>  15964
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  15964
tcaaggaaga uggcauuucu ag                                               22

<210>  15965
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15965
tcaaggaaga uggcauuucu ag                                               22

<210>  15966
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15966
tcaaggaaga uggcauuucu ag                                               22

<210>  15967
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15967
tcaaggaaga uggcauuucu ag                                               22

<210>  15968
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15968
tcaaggaaga uggcauuucu ag                                               22

<210>  15969
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15969
tcaaggaaga uggcauuucu ag                                               22

<210>  15970
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15970
tcaaggaaga uggcauuucu ag                                               22

<210>  15971
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15971
tcaaggaaga uggcauuucu ag                                               22

<210>  15972
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  15972
tcaaggaaga uggcauuucu ag                                               22

<210>  15973
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  15973
tcaaggaaga uggcat                                                      16

<210>  15974
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  15974
tcaaggaaga uggcat                                                      16

<210>  15975
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  15975
ucaaggaaga uggcau                                                      16

<210>  15976
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  15976
gaagauggca uuuct                                                       15

<210>  15977
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15977
gguaaguucu guccaagc                                                    18

<210>  15978
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15978
gguaaguuct guccaagc                                                    18

<210>  15979
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15979
gguaaguucu guccaagc                                                    18

<210>  15980
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15980
gguaaguucu guccaagc                                                    18

<210>  15981
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15981
gguaaguucu guccaagc                                                    18

<210>  15982
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15982
gguaaguucu guccaagc                                                    18

<210>  15983
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15983
gguaaguucu guccaagc                                                    18

<210>  15984
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15984
gguaaguucu guccaagc                                                    18

<210>  15985
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15985
gguaaguucu guccaagc                                                    18

<210>  15986
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15986
gguaaguucu guccaagc                                                    18

<210>  15987
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15987
gguaaguucu guccaagc                                                    18

<210>  15988
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  15988
gguaaguucu guccaagc                                                    18

<210>  15989
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15989
guaaguucug uccaagcc                                                    18

<210>  15990
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15990
guaaguucug uccaagcc                                                    18

<210>  15991
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15991
agucgguaag uucugucc                                                    18

<210>  15992
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15992
agucgguaag uucugucc                                                    18

<210>  15993
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15993
agucgguaag uucugucc                                                    18

<210>  15994
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15994
agucgguaag uucugucc                                                    18

<210>  15995
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15995
agucgguaag uucugucc                                                    18

<210>  15996
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15996
agucgguaag uucugucc                                                    18

<210>  15997
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15997
agucgguaag uucugucc                                                    18

<210>  15998
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15998
agucgguaag uucugucc                                                    18

<210>  15999
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  15999
agucgguaag uucugucc                                                    18

<210>  16000
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16000
agucgguaag uucugucc                                                    18

<210>  16001
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16001
cuguccaagc ccgguuga                                                    18

<210>  16002
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16002
cuguccaagc ccgguuga                                                    18

<210>  16003
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16003
cuguccaagc ccgguuga                                                    18

<210>  16004
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16004
cuguccaagc ccgguuga                                                    18

<210>  16005
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16005
cuguccaagc ccgguuga                                                    18

<210>  16006
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16006
cuguccaagc ccgguuga                                                    18

<210>  16007
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16007
cuguccaagc ccgguuga                                                    18

<210>  16008
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16008
cuguccaagc ccgguuga                                                    18

<210>  16009
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16009
cuguccaagc ccgguuga                                                    18

<210>  16010
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16010
cuguccaagc ccgguuga                                                    18

<210>  16011
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16011
cuguccaagc ccgguuga                                                    18

<210>  16012
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  16012
taaguucugu ccaag                                                       15

<210>  16013
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  16013
taaguucugu ccaag                                                       15

<210>  16014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16014
tcaaggaaga uggcauuucu                                                  20

<210>  16015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  16015
ucaaggaaga uggcauuucu                                                  20

<210>  16016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16016
tcaaggaaga uggcauuuct                                                  20

<210>  16017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16017
tcaaggaaga uggcauuucu                                                  20

<210>  16018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16018
tcaaggaaga uggcauuucu                                                  20

<210>  16019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16019
tcaaggaaga uggcauuuct                                                  20

<210>  16020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16020
tcaaggaaga uggcauuuct                                                  20

<210>  16021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16021
tcaaggaaga uggcauuuct                                                  20

<210>  16022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16022
tcaaggaaga uggcauuuct                                                  20

<210>  16023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16023
tcaaggaaga tggcauuuct                                                  20

<210>  16024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16024
tcaaggaaga uggcauuuct                                                  20

<210>  16025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16025
tcaaggaaga uggcauuuct                                                  20

<210>  16026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16026
tcaaggaaga uggcauuuct                                                  20

<210>  16027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16027
tcaaggaaga uggcauuuct                                                  20

<210>  16028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16028
tcaaggaaga uggcauuuct                                                  20

<210>  16029
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16029
tcaaggaaga uggcauuucu ag                                               22

<210>  16030
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16030
tcaaggaaga uggcauuucu ag                                               22

<210>  16031
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16031
tcaaggaaga uggcauuucu ag                                               22

<210>  16032
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16032
tcaaggaaga uggcauuucu ag                                               22

<210>  16033
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16033
tcaaggaaga uggcauuucu ag                                               22

<210>  16034
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16034
tcaaggaaga uggcauuucu ag                                               22

<210>  16035
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16035
tcaaggaaga uggcauuucu ag                                               22

<210>  16036
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16036
tcaaggaaga uggcauuucu ag                                               22

<210>  16037
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16037
tcaaggaaga uggcauuucu ag                                               22

<210>  16038
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16038
tcaaggaaga uggcauuucu ag                                               22

<210>  16039
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  16039
tcaaggaaga uggcat                                                      16

<210>  16040
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  16040
tcaaggaaga uggcat                                                      16

<210>  16041
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  16041
ucaaggaaga uggcau                                                      16

<210>  16042
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  16042
gaagauggca uuuct                                                       15

<210>  16043
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16043
ggtaagttct gtccaagc                                                    18

<210>  16044
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16044
ggtaagttct gtccaagc                                                    18

<210>  16045
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16045
ggtaagttct gtccaagc                                                    18

<210>  16046
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16046
ggtaagttct gtccaagc                                                    18

<210>  16047
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16047
ggtaagttct gtccaagc                                                    18

<210>  16048
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16048
ggtaagttct gtccaagc                                                    18

<210>  16049
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16049
ggtaagttct gtccaagc                                                    18

<210>  16050
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16050
ggtaagttct gtccaagc                                                    18

<210>  16051
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16051
ggtaagttct gtccaagc                                                    18

<210>  16052
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16052
ggtaagttct gtccaagc                                                    18

<210>  16053
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16053
ggtaagttct gtccaagc                                                    18

<210>  16054
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16054
ggtaagttct gtccaagc                                                    18

<210>  16055
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16055
gtaagttctg tccaagcc                                                    18

<210>  16056
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16056
gtaagttctg tccaagcc                                                    18

<210>  16057
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16057
agtcggtaag ttctgtcc                                                    18

<210>  16058
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16058
agtcggtaag ttctgtcc                                                    18

<210>  16059
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16059
agtcggtaag ttctgtcc                                                    18

<210>  16060
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16060
agtcggtaag ttctgtcc                                                    18

<210>  16061
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16061
agtcggtaag ttctgtcc                                                    18

<210>  16062
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16062
agtcggtaag ttctgtcc                                                    18

<210>  16063
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16063
agtcggtaag ttctgtcc                                                    18

<210>  16064
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16064
agtcggtaag ttctgtcc                                                    18

<210>  16065
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16065
agtcggtaag ttctgtcc                                                    18

<210>  16066
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16066
agtcggtaag ttctgtcc                                                    18

<210>  16067
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16067
ctgtccaagc ccggttga                                                    18

<210>  16068
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16068
ctgtccaagc ccggttga                                                    18

<210>  16069
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16069
ctgtccaagc ccggttga                                                    18

<210>  16070
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16070
ctgtccaagc ccggttga                                                    18

<210>  16071
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16071
ctgtccaagc ccggttga                                                    18

<210>  16072
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16072
ctgtccaagc ccggttga                                                    18

<210>  16073
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16073
ctgtccaagc ccggttga                                                    18

<210>  16074
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16074
ctgtccaagc ccggttga                                                    18

<210>  16075
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16075
ctgtccaagc ccggttga                                                    18

<210>  16076
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16076
ctgtccaagc ccggttga                                                    18

<210>  16077
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16077
ctgtccaagc ccggttga                                                    18

<210>  16078
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  16078
taagttctgt ccaag                                                       15

<210>  16079
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  16079
taagttctgt ccaag                                                       15

<210>  16080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  16080
tcaaggaaga tggcatttct                                                  20

<210>  16081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  16081
tcaaggaaga tggcatttct                                                  20

<210>  16082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16082
tcaaggaaga tggcatttct                                                  20

<210>  16083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  16083
tcaaggaaga tggcatttct                                                  20

<210>  16084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  16084
tcaaggaaga tggcatttct                                                  20

<210>  16085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16085
tcaaggaaga tggcatttct                                                  20

<210>  16086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16086
tcaaggaaga tggcatttct                                                  20

<210>  16087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16087
tcaaggaaga tggcatttct                                                  20

<210>  16088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16088
tcaaggaaga tggcatttct                                                  20

<210>  16089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16089
tcaaggaaga tggcatttct                                                  20

<210>  16090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16090
tcaaggaaga tggcatttct                                                  20

<210>  16091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16091
tcaaggaaga tggcatttct                                                  20

<210>  16092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16092
tcaaggaaga tggcatttct                                                  20

<210>  16093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16093
tcaaggaaga tggcatttct                                                  20

<210>  16094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<400>  16094
tcaaggaaga tggcatttct                                                  20

<210>  16095
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<400>  16095
tcaaggaaga tggcatttct ag                                               22

<210>  16096
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<400>  16096
tcaaggaaga tggcatttct ag                                               22

<210>  16097
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16097
tcaaggaaga tggcatttct ag                                               22

<210>  16098
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16098
tcaaggaaga tggcatttct ag                                               22

<210>  16099
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16099
tcaaggaaga tggcatttct ag                                               22

<210>  16100
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16100
tcaaggaaga tggcatttct ag                                               22

<210>  16101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16101
tcaaggaaga tggcatttct ag                                               22

<210>  16102
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16102
tcaaggaaga tggcatttct ag                                               22

<210>  16103
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16103
tcaaggaaga tggcatttct ag                                               22

<210>  16104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<400>  16104
tcaaggaaga tggcatttct ag                                               22

<210>  16105
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  16105
tcaaggaaga tggcat                                                      16

<210>  16106
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<400>  16106
tcaaggaaga tggcat                                                      16

<210>  16107
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  16107
tcaaggaaga tggcat                                                      16

<210>  16108
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<400>  16108
gaagatggca tttct                                                       15

<210>  16109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16109
ggtaagttct gtccaagc                                                    18

<210>  16110
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16110
ggtaagttct gtccaagc                                                    18

<210>  16111
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16111
ggtaagttct gtccaagc                                                    18

<210>  16112
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16112
ggtaagttct gtccaagc                                                    18

<210>  16113
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16113
ggtaagttct gtccaagc                                                    18

<210>  16114
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16114
ggtaagttct gtccaagc                                                    18

<210>  16115
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16115
ggtaagttct gtccaagc                                                    18

<210>  16116
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16116
ggtaagttct gtccaagc                                                    18

<210>  16117
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16117
ggtaagttct gtccaagc                                                    18

<210>  16118
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16118
ggtaagttct gtccaagc                                                    18

<210>  16119
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16119
ggtaagttct gtccaagc                                                    18

<210>  16120
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<400>  16120
ggtaagttct gtccaagc                                                    18

<210>  16121
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16121
gtaagttctg tccaagcc                                                    18

<210>  16122
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16122
gtaagttctg tccaagcc                                                    18

<210>  16123
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16123
agtcggtaag ttctgtcc                                                    18

<210>  16124
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16124
agtcggtaag ttctgtcc                                                    18

<210>  16125
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16125
agtcggtaag ttctgtcc                                                    18

<210>  16126
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16126
agtcggtaag ttctgtcc                                                    18

<210>  16127
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16127
agtcggtaag ttctgtcc                                                    18

<210>  16128
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16128
agtcggtaag ttctgtcc                                                    18

<210>  16129
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16129
agtcggtaag ttctgtcc                                                    18

<210>  16130
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16130
agtcggtaag ttctgtcc                                                    18

<210>  16131
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16131
agtcggtaag ttctgtcc                                                    18

<210>  16132
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<400>  16132
agtcggtaag ttctgtcc                                                    18

<210>  16133
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16133
ctgtccaagc ccggttga                                                    18

<210>  16134
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16134
ctgtccaagc ccggttga                                                    18

<210>  16135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16135
ctgtccaagc ccggttga                                                    18

<210>  16136
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16136
ctgtccaagc ccggttga                                                    18

<210>  16137
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16137
ctgtccaagc ccggttga                                                    18

<210>  16138
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16138
ctgtccaagc ccggttga                                                    18

<210>  16139
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16139
ctgtccaagc ccggttga                                                    18

<210>  16140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16140
ctgtccaagc ccggttga                                                    18

<210>  16141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16141
ctgtccaagc ccggttga                                                    18

<210>  16142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16142
ctgtccaagc ccggttga                                                    18

<210>  16143
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<400>  16143
ctgtccaagc ccggttga                                                    18

<210>  16144
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  16144
taagttctgt ccaag                                                       15

<210>  16145
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<400>  16145
taagttctgt ccaag                                                       15

<210>  16146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16146
tcaaggaaga tggcatttct                                                  20

<210>  16147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<400>  16147
tcaaggaaga tggcatttct                                                  20

<210>  16148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16148
tcaaggaaga tggcatttct                                                  20

<210>  16149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16149
tcaaggaaga tggcatttct                                                  20

<210>  16150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16150
tcaaggaaga tggcatttct                                                  20

<210>  16151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16151
tcaaggaaga tggcatttct                                                  20

<210>  16152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16152
tcaaggaaga tggcatttct                                                  20

<210>  16153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16153
tcaaggaaga tggcatttct                                                  20

<210>  16154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16154
tcaaggaaga tggcatttct                                                  20

<210>  16155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16155
tcaaggaaga tggcatttct                                                  20

<210>  16156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16156
tcaaggaaga tggcatttct                                                  20

<210>  16157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16157
tcaaggaaga tggcatttct                                                  20

<210>  16158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16158
tcaaggaaga tggcatttct                                                  20

<210>  16159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16159
tcaaggaaga tggcatttct                                                  20

<210>  16160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16160
tcaaggaaga tggcatttct                                                  20

<210>  16161
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16161
tcaaggaaga tggcatttct ag                                               22

<210>  16162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16162
tcaaggaaga tggcatttct ag                                               22

<210>  16163
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16163
tcaaggaaga tggcatttct ag                                               22

<210>  16164
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16164
tcaaggaaga tggcatttct ag                                               22

<210>  16165
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16165
tcaaggaaga tggcatttct ag                                               22

<210>  16166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16166
tcaaggaaga tggcatttct ag                                               22

<210>  16167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16167
tcaaggaaga tggcatttct ag                                               22

<210>  16168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16168
tcaaggaaga tggcatttct ag                                               22

<210>  16169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16169
tcaaggaaga tggcatttct ag                                               22

<210>  16170
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<400>  16170
tcaaggaaga tggcatttct ag                                               22

<210>  16171
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  16171
tcaaggaaga tggcat                                                      16

<210>  16172
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  16172
tcaaggaaga tggcat                                                      16

<210>  16173
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<400>  16173
tcaaggaaga tggcat                                                      16

<210>  16174
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<400>  16174
gaagatggca tttct                                                       15

<210>  16175
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16175
gguaaguucu guccaagcnu caaggaagau ggcauuucu                             39

<210>  16176
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16176
ucaaggaaga uggcauuucu ngguaaguuc uguccaagc                             39

<210>  16177
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16177
gguaaguucu guccaagcnu caaggaagau ggcauuucu                             39

<210>  16178
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16178
ucaaggaaga uggcauuucu ngguaaguuc uguccaagc                             39

<210>  16179
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16179
gguaaguucu guccaagcnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16180
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16180
ucaaggaaga uggcauuucu agngguaagu ucuguccaag                            40
c                                                                      41

<210>  16181
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16181
gguaaguucu guccaagcnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16182
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16182
ucaaggaaga uggcauuucu agngguaagu ucuguccaag                            40
c                                                                      41

<210>  16183
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16183
guaaguucug uccaagccnu caaggaagau ggcauuucu                             39

<210>  16184
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16184
ucaaggaaga uggcauuucu nguaaguucu guccaagcc                             39

<210>  16185
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16185
guaaguucug uccaagccnu caaggaagau ggcauuucu                             39

<210>  16186
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16186
ucaaggaaga uggcauuucu nguaaguucu guccaagcc                             39

<210>  16187
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16187
guaaguucug uccaagccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16188
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16188
ucaaggaaga uggcauuucu agnguaaguu cuguccaagc                            40
c                                                                      41

<210>  16189
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16189
guaaguucug uccaagccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16190
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16190
ucaaggaaga uggcauuucu agnguaaguu cuguccaagc                            40
c                                                                      41

<210>  16191
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16191
agucgguaag uucuguccnu caaggaagau ggcauuucu                             39

<210>  16192
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16192
ucaaggaaga uggcauuucu nagucgguaa guucugucc                             39

<210>  16193
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16193
agucgguaag uucuguccnu caaggaagau ggcauuucu                             39

<210>  16194
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16194
ucaaggaaga uggcauuucu nagucgguaa guucugucc                             39

<210>  16195
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16195
agucgguaag uucuguccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16196
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16196
ucaaggaaga uggcauuucu agnagucggu aaguucuguc                            40
c                                                                      41

<210>  16197
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16197
agucgguaag uucuguccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16198
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16198
ucaaggaaga uggcauuucu agnagucggu aaguucuguc                            40
c                                                                      41

<210>  16199
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16199
cuguccaagc ccgguuganu caaggaagau ggcauuucu                             39

<210>  16200
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16200
ucaaggaaga uggcauuucu ncuguccaag cccgguuga                             39

<210>  16201
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16201
cuguccaagc ccgguuganu caaggaagau ggcauuucu                             39

<210>  16202
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16202
ucaaggaaga uggcauuucu ncuguccaag cccgguuga                             39

<210>  16203
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16203
cuguccaagc ccgguuganu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16204
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16204
ucaaggaaga uggcauuucu agncugucca agcccgguug                            40
a                                                                      41

<210>  16205
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16205
cuguccaagc ccgguuganu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16206
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16206
ucaaggaaga uggcauuucu agncugucca agcccgguug                            40
a                                                                      41

<210>  16207
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16207
uaaguucugu ccaagnucaa ggaagauggc au                                    32

<210>  16208
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is tri-ethylene glycol (TEG)

<400>  16208
ucaaggaaga uggcaunuaa guucugucca ag                                    32

<210>  16209
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16209
uaaguucugu ccaagnucaa ggaagauggc au                                    32

<210>  16210
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16210
ucaaggaaga uggcaunuaa guucugucca ag                                    32

<210>  16211
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16211
uaaguucugu ccaagngaag auggcauuuc u                                     31

<210>  16212
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16212
gaagauggca uuucunuaag uucuguccaa g                                     31

<210>  16213
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16213
uaaguucugu ccaagngaag auggcauuuc u                                     31

<210>  16214
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16214
gaagauggca uuucunuaag uucuguccaa g                                     31

<210>  16215
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16215
gguaaguucu guccaagcnu caaggaagau ggcauuucu                             39

<210>  16216
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16216
ucaaggaaga uggcauuucu ngguaaguuc uguccaagc                             39

<210>  16217
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16217
gguaaguucu guccaagcnu caaggaagau ggcauuucu                             39

<210>  16218
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16218
ucaaggaaga uggcauuucu ngguaaguuc uguccaagc                             39

<210>  16219
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16219
gguaaguucu guccaagcnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16220
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16220
ucaaggaaga uggcauuucu agngguaagu ucuguccaag                            40
c                                                                      41

<210>  16221
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16221
gguaaguucu guccaagcnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16222
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16222
ucaaggaaga uggcauuucu agngguaagu ucuguccaag                            40
c                                                                      41

<210>  16223
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16223
guaaguucug uccaagccnu caaggaagau ggcauuucu                             39

<210>  16224
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16224
ucaaggaaga uggcauuucu nguaaguucu guccaagcc                             39

<210>  16225
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16225
guaaguucug uccaagccnu caaggaagau ggcauuucu                             39

<210>  16226
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16226
ucaaggaaga uggcauuucu nguaaguucu guccaagcc                             39

<210>  16227
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16227
guaaguucug uccaagccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16228
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16228
ucaaggaaga uggcauuucu agnguaaguu cuguccaagc                            40
c                                                                      41

<210>  16229
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16229
guaaguucug uccaagccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16230
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16230
ucaaggaaga uggcauuucu agnguaaguu cuguccaagc                            40
c                                                                      41

<210>  16231
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16231
agucgguaag uucuguccnu caaggaagau ggcauuucu                             39

<210>  16232
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16232
ucaaggaaga uggcauuucu nagucgguaa guucugucc                             39

<210>  16233
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16233
agucgguaag uucuguccnu caaggaagau ggcauuucu                             39

<210>  16234
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16234
ucaaggaaga uggcauuucu nagucgguaa guucugucc                             39

<210>  16235
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16235
agucgguaag uucuguccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16236
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16236
ucaaggaaga uggcauuucu agnagucggu aaguucuguc                            40
c                                                                      41

<210>  16237
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16237
agucgguaag uucuguccnu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16238
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16238
ucaaggaaga uggcauuucu agnagucggu aaguucuguc                            40
c                                                                      41

<210>  16239
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16239
cuguccaagc ccgguuganu caaggaagau ggcauuucu                             39

<210>  16240
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16240
ucaaggaaga uggcauuucu ncuguccaag cccgguuga                             39

<210>  16241
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16241
cuguccaagc ccgguuganu caaggaagau ggcauuucu                             39

<210>  16242
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16242
ucaaggaaga uggcauuucu ncuguccaag cccgguuga                             39

<210>  16243
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16243
cuguccaagc ccgguuganu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16244
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16244
ucaaggaaga uggcauuucu agncugucca agcccgguug                            40
a                                                                      41

<210>  16245
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16245
cuguccaagc ccgguuganu caaggaagau ggcauuucua                            40
g                                                                      41

<210>  16246
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16246
ucaaggaaga uggcauuucu agncugucca agcccgguug                            40
a                                                                      41

<210>  16247
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16247
uaaguucugu ccaagnucaa ggaagauggc au                                    32

<210>  16248
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is tri-ethylene glycol (TEG)

<400>  16248
ucaaggaaga uggcaunuaa guucugucca ag                                    32

<210>  16249
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16249
uaaguucugu ccaagnucaa ggaagauggc au                                    32

<210>  16250
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16250
ucaaggaaga uggcaunuaa guucugucca ag                                    32

<210>  16251
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16251
uaaguucugu ccaagngaag auggcauuuc u                                     31

<210>  16252
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16252
gaagauggca uuucunuaag uucuguccaa g                                     31

<210>  16253
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16253
uaaguucugu ccaagngaag auggcauuuc u                                     31

<210>  16254
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16254
gaagauggca uuucunuaag uucuguccaa g                                     31

<210>  16255
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16255
ggtaagttct gtccaagcnt caaggaagat ggcatttct                             39

<210>  16256
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16256
tcaaggaaga tggcatttct nggtaagttc tgtccaagc                             39

<210>  16257
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16257
ggtaagttct gtccaagcnt caaggaagat ggcatttct                             39

<210>  16258
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16258
tcaaggaaga tggcatttct nggtaagttc tgtccaagc                             39

<210>  16259
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16259
ggtaagttct gtccaagcnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16260
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16260
tcaaggaaga tggcatttct agnggtaagt tctgtccaag                            40
c                                                                      41

<210>  16261
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16261
ggtaagttct gtccaagcnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16262
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16262
tcaaggaaga tggcatttct agnggtaagt tctgtccaag                            40
c                                                                      41

<210>  16263
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16263
gtaagttctg tccaagccnt caaggaagat ggcatttct                             39

<210>  16264
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16264
tcaaggaaga tggcatttct ngtaagttct gtccaagcc                             39

<210>  16265
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16265
gtaagttctg tccaagccnt caaggaagat ggcatttct                             39

<210>  16266
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16266
tcaaggaaga tggcatttct ngtaagttct gtccaagcc                             39

<210>  16267
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16267
gtaagttctg tccaagccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16268
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16268
tcaaggaaga tggcatttct agngtaagtt ctgtccaagc                            40
c                                                                      41

<210>  16269
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16269
gtaagttctg tccaagccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16270
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16270
tcaaggaaga tggcatttct agngtaagtt ctgtccaagc                            40
c                                                                      41

<210>  16271
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16271
agtcggtaag ttctgtccnt caaggaagat ggcatttct                             39

<210>  16272
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16272
tcaaggaaga tggcatttct nagtcggtaa gttctgtcc                             39

<210>  16273
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16273
agtcggtaag ttctgtccnt caaggaagat ggcatttct                             39

<210>  16274
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16274
tcaaggaaga tggcatttct nagtcggtaa gttctgtcc                             39

<210>  16275
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16275
agtcggtaag ttctgtccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16276
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16276
tcaaggaaga tggcatttct agnagtcggt aagttctgtc                            40
c                                                                      41

<210>  16277
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16277
agtcggtaag ttctgtccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16278
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16278
tcaaggaaga tggcatttct agnagtcggt aagttctgtc                            40
c                                                                      41

<210>  16279
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16279
ctgtccaagc ccggttgant caaggaagat ggcatttct                             39

<210>  16280
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16280
tcaaggaaga tggcatttct nctgtccaag cccggttga                             39

<210>  16281
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16281
ctgtccaagc ccggttgant caaggaagat ggcatttct                             39

<210>  16282
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16282
tcaaggaaga tggcatttct nctgtccaag cccggttga                             39

<210>  16283
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16283
ctgtccaagc ccggttgant caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16284
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16284
tcaaggaaga tggcatttct agnctgtcca agcccggttg                            40
a                                                                      41

<210>  16285
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16285
ctgtccaagc ccggttgant caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16286
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16286
tcaaggaaga tggcatttct agnctgtcca agcccggttg                            40
a                                                                      41

<210>  16287
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16287
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16288
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is tri-ethylene glycol (TEG)

<400>  16288
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16289
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16289
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16290
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16290
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16291
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16291
taagttctgt ccaagngaag atggcatttc t                                     31

<210>  16292
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16292
gaagatggca tttctntaag ttctgtccaa g                                     31

<210>  16293
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16293
taagttctgt ccaagngaag atggcatttc t                                     31

<210>  16294
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16294
gaagatggca tttctntaag ttctgtccaa g                                     31

<210>  16295
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16295
ggtaagttct gtccaagcnt caaggaagat ggcatttct                             39

<210>  16296
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16296
tcaaggaaga tggcatttct nggtaagttc tgtccaagc                             39

<210>  16297
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16297
ggtaagttct gtccaagcnt caaggaagat ggcatttct                             39

<210>  16298
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16298
tcaaggaaga tggcatttct nggtaagttc tgtccaagc                             39

<210>  16299
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16299
ggtaagttct gtccaagcnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16300
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16300
tcaaggaaga tggcatttct agnggtaagt tctgtccaag                            40
c                                                                      41

<210>  16301
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16301
ggtaagttct gtccaagcnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16302
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16302
tcaaggaaga tggcatttct agnggtaagt tctgtccaag                            40
c                                                                      41

<210>  16303
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16303
gtaagttctg tccaagccnt caaggaagat ggcatttct                             39

<210>  16304
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16304
tcaaggaaga tggcatttct ngtaagttct gtccaagcc                             39

<210>  16305
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16305
gtaagttctg tccaagccnt caaggaagat ggcatttct                             39

<210>  16306
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16306
tcaaggaaga tggcatttct ngtaagttct gtccaagcc                             39

<210>  16307
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16307
gtaagttctg tccaagccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16308
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16308
tcaaggaaga tggcatttct agngtaagtt ctgtccaagc                            40
c                                                                      41

<210>  16309
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16309
gtaagttctg tccaagccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16310
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16310
tcaaggaaga tggcatttct agngtaagtt ctgtccaagc                            40
c                                                                      41

<210>  16311
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16311
agtcggtaag ttctgtccnt caaggaagat ggcatttct                             39

<210>  16312
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16312
tcaaggaaga tggcatttct nagtcggtaa gttctgtcc                             39

<210>  16313
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16313
agtcggtaag ttctgtccnt caaggaagat ggcatttct                             39

<210>  16314
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16314
tcaaggaaga tggcatttct nagtcggtaa gttctgtcc                             39

<210>  16315
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16315
agtcggtaag ttctgtccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16316
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16316
tcaaggaaga tggcatttct agnagtcggt aagttctgtc                            40
c                                                                      41

<210>  16317
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16317
agtcggtaag ttctgtccnt caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16318
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16318
tcaaggaaga tggcatttct agnagtcggt aagttctgtc                            40
c                                                                      41

<210>  16319
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16319
ctgtccaagc ccggttgant caaggaagat ggcatttct                             39

<210>  16320
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16320
tcaaggaaga tggcatttct nctgtccaag cccggttga                             39

<210>  16321
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16321
ctgtccaagc ccggttgant caaggaagat ggcatttct                             39

<210>  16322
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16322
tcaaggaaga tggcatttct nctgtccaag cccggttga                             39

<210>  16323
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16323
ctgtccaagc ccggttgant caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16324
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is tri-ethylene glycol (TEG)

<400>  16324
tcaaggaaga tggcatttct agnctgtcca agcccggttg                            40
a                                                                      41

<210>  16325
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16325
ctgtccaagc ccggttgant caaggaagat ggcatttcta                            40
g                                                                      41

<210>  16326
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16326
tcaaggaaga tggcatttct agnctgtcca agcccggttg                            40
a                                                                      41

<210>  16327
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16327
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16328
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is tri-ethylene glycol (TEG)

<400>  16328
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16329
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16329
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16330
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16330
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16331
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16331
taagttctgt ccaagngaag atggcatttc t                                     31

<210>  16332
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16332
gaagatggca tttctntaag ttctgtccaa g                                     31

<210>  16333
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16333
taagttctgt ccaagngaag atggcatttc t                                     31

<210>  16334
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16334
gaagatggca tttctntaag ttctgtccaa g                                     31

<210>  16335
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is tri-ethylene glycol (TEG)

<400>  16335
gguaaguucu guccaagcnt caaggaagau ggcauuuct                             39

<210>  16336
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is tri-ethylene glycol (TEG)

<400>  16336
tcaaggaaga uggcauuuct ngguaaguuc uguccaagc                             39

<210>  16337
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16337
gguaaguucu guccaagcnt caaggaagau ggcauuuct                             39

<210>  16338
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16338
tcaaggaaga uggcauuuct ngguaaguuc uguccaagc                             39

<210>  16339
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16339
taagttctgt ccaagngaag atggcatttc t                                     31

<210>  16340
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16340
gaagatggca tttctntaag ttctgtccaa g                                     31

<210>  16341
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16341
taagttctgt ccaagngaag atggcatttc t                                     31

<210>  16342
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16342
gaagatggca tttctntaag ttctgtccaa g                                     31

<210>  16343
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16343
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16344
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is tri-ethylene glycol (TEG)

<400>  16344
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16345
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16345
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16346
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16346
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16347
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is tri-ethylene glycol (TEG)

<400>  16347
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16348
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is tri-ethylene glycol (TEG)

<400>  16348
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16349
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16349
taagttctgt ccaagntcaa ggaagatggc at                                    32

<210>  16350
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is hexa-ethylene glycol (HEG)

<400>  16350
tcaaggaaga tggcatntaa gttctgtcca ag                                    32

<210>  16351
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  5-methyl

<400>  16351
taagttctgt ccaagtcaag gaagatggca t                                     31

<210>  16352
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  5-methyl

<400>  16352
tcaaggaaga tggcattaag ttctgtccaa g                                     31

<210>  16353
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5-methyl

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  bicyclic nucleic acid (BNA)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  bicyclic nucleic acid (BNA)

<400>  16353
caaggaagau ggcauuuct                                                   19



