                         SEQUENCE LISTING

<110>  NantKWest
 
<120>  ELIMINATION OF CD19-POSITIVE LYMPHOID MALIGNANCIES BY CD19-CAR 
       EXPRESSING NK CELLS

<130>  104077.0008PCT

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Laboratory sequence

<400>  1

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210>  2
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  2

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210>  3
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  3

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  4
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory made

<400>  4

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  5
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  laboratory made

<400>  5
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagggt gctcgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcgacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaagg caggaagtat tttcatcata attctgactt ctacattcca      480

aaagccacac tcaaagacag cggctcctac ttctgcaggg ggctttttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctttc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattc gaagctcaac aagagactgg      720

aaggaccata aatttaaatg gagaaaggac cctcaagaca aatga                      765


<210>  6
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  6

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  7
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  7

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


<210>  8
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  8
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  9
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  9
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tct                                   813


<210>  10
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  10

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265                 270     


<210>  11
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  11
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgcggccg cgctgagcaa cagcatcatg      840

tacttcagcc acttcgtgcc tgtgttcctg cctgccaagc ctacaacaac accagcccct      900

agacctccaa cccctgcccc tacaattgcc tctcagcctc tgtctctgag gcccgaagct      960

tgtagacctg ctgctggcgg agctgtgcac accagaggac tggatttcgc ctgcttttgg     1020

gtgctggtgg tcgtgggcgg agtgctggct tgttattctc tgctggtcac cgtggccttc     1080

atcatctttt gggtccgact gaagatccag gtccgaaagg ccgccatcac cagctacgag     1140

aagtctgatg gcgtgtacac cggcctgagc accagaaacc aggaaaccta cgagacactg     1200

aagcacgaga agccccccca g                                               1221


<210>  12
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  12

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            260                 265                 270         


Ala Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
        275                 280                 285             


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    290                 295                 300                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
305                 310                 315                 320 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                325                 330                 335     


Ala Cys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            340                 345                 350         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Leu Lys 
        355                 360                 365             


Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly 
    370                 375                 380                 


Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu 
385                 390                 395                 400 


Lys His Glu Lys Pro Pro Gln 
                405         


<210>  13
<211>  6778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  13
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct       60

gacgtcgacg gatcgggaga tctcccgatc ccctatggtg cactctcagt acaatctgct      120

ctgatgccgc atagttaagc cagtatctgc tccctgcttg tgtgttggag gtcgctgagt      180

agtgcgcgag caaaatttaa gctacaacaa ggcaaggctt gaccgacaat tgcatgaaga      240

atctgcttag ggttaggcgt tttgcgctgc ttcgggatcc gctgaccaaa agagcaccaa      300

aggcgccctg accttcagcc cctacctgcg ctccggtgcc cgtcagtggg cagagcgcac      360

atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag      420

aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga      480

gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg      540

gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg gcctctttac      600

gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg tgattcttga      660

tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt aaggagcccc      720

ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg tgcgaatctg      780

gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt aaaatttttg      840

atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg gccaagatct      900

gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg cgtcccagcg      960

cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac gggggtagtc     1020

tcaagctggc cggcctgctc tggtgcctgg cctcgcgccg ccgtgtatcg ccccgccctg     1080

ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc cgcttcccgg     1140

ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg cgggtgagtc     1200

acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg actccacgga     1260

gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta cgtcgtcttt     1320

aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg tggagactga     1380

agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt ttgagtttgg     1440

atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc catttcaggt     1500

gtcgtgataa tacgactcac tatagggaga cccaagctgg aattcgccac catggactgg     1560

atctggcgga ttctgtttct cgtgggagct gccacaggcg ctcattctgc tcagcctgcc     1620

gatatccaga tgacccagac aacaagcagc ctgagcgcct ctctgggcga tagagtgaca     1680

atcagctgca gagccagcca ggacatcagc aagtacctga actggtatca gcagaaaccc     1740

gacggcaccg tgaagctgct gatctaccac acaagcagac tgcacagcgg cgtgccaagc     1800

agattttctg gcagcggcag cggcaccgat tacagcctga ccatcagcaa cctggaacag     1860

gaagatatcg ctacctactt ctgtcagcag ggcaacaccc tgccttacac ctttggcggc     1920

ggaacaaagc tggaactgaa aagaggcggc ggaggaagcg gaggcggagg atctgggggc     1980

ggaggctctg gcggaggggg atctgaagtg cagctgcagc agtctggacc tggactggtg     2040

gctccttctc agtccctgtc tgtgacctgt acagtgtctg gcgtgtccct gcctgattac     2100

ggcgtgtcct ggatcagaca gcctcccaga aaaggcctgg aatggctggg agtgatctgg     2160

ggcagcgaga caacctacta caacagcgcc ctgaagtccc ggctgaccat catcaaggac     2220

aacagcaaga gccaggtgtt cctgaagatg aacagcctgc agaccgacga caccgccatc     2280

tactactgcg ccaagcacta ctactacggc ggcagctacg ccatggatta ttggggccag     2340

ggcaccaccg tgacagtgtc atctgcggcc gcgctgagca acagcatcat gtacttcagc     2400

cacttcgtgc ctgtgttcct gcctgccaag cctacaacaa caccagcccc tagacctcca     2460

acccctgccc ctacaattgc ctctcagcct ctgtctctga ggcccgaagc ttgtagacct     2520

gctgctggcg gagctgtgca caccagagga ctggatttcg cctgcttttg ggtgctggtg     2580

gtcgtgggcg gagtgctggc ttgttattct ctgctggtca ccgtggcctt catcatcttt     2640

tgggtccgac tgaagatcca ggtccgaaag gccgccatca ccagctacga gaagtctgat     2700

ggcgtgtaca ccggcctgag caccagaaac caggaaacct acgagacact gaagcacgag     2760

aagccccccc agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     2820

gaggagaacc ctggacctat gtggcagctg ctgctgccta cagctctcct gctgctggtg     2880

tccgccggca tgagaaccga ggatctgcct aaggccgtgg tgttcctgga accccagtgg     2940

tacagagtgc tggaaaagga cagcgtgacc ctgaagtgcc agggcgccta cagccccgag     3000

gacaatagca cccagtggtt ccacaacgag agcctgatca gcagccaggc cagcagctac     3060

ttcatcgacg ccgccaccgt ggacgacagc ggcgagtata gatgccagac caacctgagc     3120

accctgagcg accccgtgca gctggaagtg cacatcggat ggctgctgct gcaggccccc     3180

agatgggtgt tcaaagaaga ggaccccatc cacctgagat gccactcttg gaagaacacc     3240

gccctgcaca aagtgaccta cctgcagaac ggcaagggca gaaagtactt ccaccacaac     3300

agcgacttct acatccccaa ggccaccctg aaggactccg gctcctactt ctgcagaggc     3360

ctcgtgggca gcaagaacgt gtccagcgag acagtgaaca tcaccatcac ccagggcctg     3420

gccgtgtcta ccatcagcag ctttttccca cccggctacc aggtgtcctt ctgcctcgtg     3480

atggtgctgc tgttcgccgt ggacaccggc ctgtacttca gcgtgaaaac aaacatcaga     3540

agcagcaccc gggactggaa ggaccacaag ttcaagtggc ggaaggaccc ccaggacaag     3600

tgaaattccg cccctctccc ccccccccct ctccctcccc cccccctaac gttactggcc     3660

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     3720

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     3780

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     3840

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     3900

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     3960

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     4020

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     4080

tgggatctga tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa     4140

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgataaccgc     4200

caccatgtac cggatgcagc tgctgagctg tatcgccctg tctctggccc tcgtgaccaa     4260

cagcgcccct accagcagca gcaccaagaa aacccagctg cagctggaac atctgctgct     4320

ggacctgcag atgatcctga acggcatcaa caactacaag aaccccaagc tgacccggat     4380

gctgaccttc aagttctaca tgcccaagaa ggccaccgaa ctgaaacatc tgcagtgcct     4440

ggaagaggaa ctgaagcccc tggaagaagt gctgaacctg gcccagagca agaacttcca     4500

cctgaggccc agggacctga tcagcaacat caacgtgatc gtgctggaac tgaaaggcag     4560

cgagacaacc ttcatgtgcg agtacgccga cgagacagct accatcgtgg aatttctgaa     4620

ccggtggatc accttctgcc agagcatcat cagcaccctg accggctccg agaaggacga     4680

gctgtgagcg gccgcccgct gatcagcctc gaacgagatt tcgattccac cgccgccttc     4740

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc     4800

ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt     4860

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4920

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtgcggt gggctctatg     4980

gcttctgagg cggaaagaac cagctggggc tctagggggt atccccggat cctgagcaaa     5040

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     5100

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     5160

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     5220

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     5280

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     5340

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     5400

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     5460

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     5520

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     5580

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     5640

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     5700

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     5760

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     5820

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     5880

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     5940

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag aaccacgctc     6000

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     6060

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     6120

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     6180

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     6240

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     6300

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     6360

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     6420

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     6480

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     6540

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     6600

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     6660

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     6720

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaa       6778


<210>  14
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  14

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            260                 265                 270         


Ala Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val 
        275                 280                 285             


Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    290                 295                 300                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
305                 310                 315                 320 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                325                 330                 335     


Ala Cys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
            340                 345                 350         


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Leu Lys 
        355                 360                 365             


Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly 
    370                 375                 380                 


Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu 
385                 390                 395                 400 


Lys His Glu Lys Pro Pro Gln Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                405                 410                 415     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Gln 
            420                 425                 430         


Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala Gly Met Arg 
        435                 440                 445             


Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp Tyr 
    450                 455                 460                 


Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala Tyr 
465                 470                 475                 480 


Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu Ile 
                485                 490                 495     


Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp Asp 
            500                 505                 510         


Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp Pro 
        515                 520                 525             


Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro Arg 
    530                 535                 540                 


Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser Trp 
545                 550                 555                 560 


Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys Gly 
                565                 570                 575     


Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala Thr 
            580                 585                 590         


Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser Lys 
        595                 600                 605             


Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu Ala 
    610                 615                 620                 


Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe 
625                 630                 635                 640 


Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe 
                645                 650                 655     


Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His 
            660                 665                 670         


Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
        675                 680             


<210>  15
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  laboratory sequence

<400>  15

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


