                         SEQUENCE LISTING

<110>  GENOCEA BIOSCIENCES, INC.
 
<120>  TREATMENT METHODS

<130>  2007781-0247

<140>  PCT/US 19/58578
<141>  2019-10-29

<150>  62/752,288
<151>  2018-10-29

<150>  62/788,313
<151>  2019-01-04

<150>  62/855,332
<151>  2019-05-31

<160>  452   

<170>  PatentIn version 3.5

<210>  1
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  1

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  2
<211>  506
<212>  PRT
<213>  Listeria monocytogenes

<400>  2

Met Lys Asp Ala Ser Ala Phe Asn Lys Glu Asn Ser Ile Ser Ser Met 
1               5                   10                  15      


Ala Pro Pro Ala Ser Pro Pro Ala Ser Pro Lys Thr Pro Ile Glu Lys 
            20                  25                  30          


Lys His Ala Asp Glu Ile Asp Lys Tyr Ile Gln Gly Leu Asp Tyr Asn 
        35                  40                  45              


Lys Asn Asn Val Leu Val Tyr His Gly Asp Ala Val Thr Asn Val Pro 
    50                  55                  60                  


Pro Arg Lys Gly Tyr Lys Asp Gly Asn Glu Tyr Ile Val Val Glu Lys 
65                  70                  75                  80  


Lys Lys Lys Ser Ile Asn Gln Asn Asn Ala Asp Ile Gln Val Val Asn 
                85                  90                  95      


Ala Ile Ser Ser Leu Thr Tyr Pro Gly Ala Leu Val Lys Ala Asn Ser 
            100                 105                 110         


Glu Leu Val Glu Asn Gln Pro Asp Val Leu Pro Val Lys Arg Asp Ser 
        115                 120                 125             


Leu Thr Leu Ser Ile Asp Leu Pro Gly Met Thr Asn Gln Asp Asn Lys 
    130                 135                 140                 


Ile Val Val Lys Asn Ala Thr Lys Ser Asn Val Asn Asn Ala Val Asn 
145                 150                 155                 160 


Thr Leu Val Glu Arg Trp Asn Glu Lys Tyr Ala Gln Ala Tyr Pro Asn 
                165                 170                 175     


Val Ser Ala Lys Ile Asp Tyr Asp Asp Glu Met Ala Tyr Ser Glu Ser 
            180                 185                 190         


Gln Leu Ile Ala Lys Phe Gly Thr Ala Phe Lys Ala Val Asn Asn Ser 
        195                 200                 205             


Leu Asn Val Asn Phe Gly Ala Ile Ser Glu Gly Lys Met Gln Glu Glu 
    210                 215                 220                 


Val Ile Ser Phe Lys Gln Ile Tyr Tyr Asn Val Asn Val Asn Glu Pro 
225                 230                 235                 240 


Thr Arg Pro Ser Arg Phe Phe Gly Lys Ala Val Thr Lys Glu Gln Leu 
                245                 250                 255     


Gln Ala Leu Gly Val Asn Ala Glu Asn Pro Pro Ala Tyr Ile Ser Ser 
            260                 265                 270         


Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Ser Thr Asn Ser His 
        275                 280                 285             


Ser Thr Lys Val Lys Ala Ala Phe Asp Ala Ala Val Ser Gly Lys Ser 
    290                 295                 300                 


Val Ser Gly Asp Val Glu Leu Thr Asn Ile Ile Lys Asn Ser Ser Phe 
305                 310                 315                 320 


Lys Ala Val Ile Tyr Gly Gly Ser Ala Lys Asp Glu Val Gln Ile Ile 
                325                 330                 335     


Asp Gly Asn Leu Gly Asp Leu Arg Asp Ile Leu Lys Lys Gly Ala Thr 
            340                 345                 350         


Phe Asn Arg Glu Thr Pro Gly Val Pro Ile Ala Tyr Thr Thr Asn Phe 
        355                 360                 365             


Leu Lys Asp Asn Glu Leu Ala Val Ile Lys Asn Asn Ser Glu Tyr Ile 
    370                 375                 380                 


Glu Thr Thr Ser Lys Ala Tyr Thr Asp Gly Lys Ile Asn Ile Asp His 
385                 390                 395                 400 


Ser Gly Gly Tyr Val Ala Gln Phe Asn Ile Ser Trp Asp Glu Val Asn 
                405                 410                 415     


Tyr Asp Pro Glu Gly Asn Glu Ile Val Gln His Lys Asn Trp Ser Glu 
            420                 425                 430         


Asn Asn Lys Ser Lys Leu Ala His Phe Thr Ser Ser Ile Tyr Leu Pro 
        435                 440                 445             


Gly Asn Ala Arg Asn Ile Asn Val Tyr Ala Lys Glu Cys Thr Gly Leu 
    450                 455                 460                 


Ala Trp Glu Trp Trp Arg Thr Val Ile Asp Asp Arg Asn Leu Pro Leu 
465                 470                 475                 480 


Val Lys Asn Arg Asn Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Lys 
                485                 490                 495     


Tyr Ser Asn Lys Val Asp Asn Pro Ile Glu 
            500                 505     


<210>  3
<211>  571
<212>  PRT
<213>  Streptococcus pyogenes

<400>  3

Met Ser Asn Lys Lys Thr Phe Lys Lys Tyr Ser Arg Val Ala Gly Leu 
1               5                   10                  15      


Leu Thr Ala Ala Leu Ile Ile Gly Asn Leu Val Thr Ala Asn Ala Glu 
            20                  25                  30          


Ser Asn Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Ser Glu 
        35                  40                  45              


Gln Pro Lys Pro Glu Ser Ser Glu Leu Thr Ile Glu Lys Ala Gly Gln 
    50                  55                  60                  


Lys Met Asp Asp Met Leu Asn Ser Asn Asp Met Ile Lys Leu Ala Pro 
65                  70                  75                  80  


Lys Glu Met Pro Leu Glu Ser Ala Glu Lys Glu Glu Lys Lys Ser Glu 
                85                  90                  95      


Asp Lys Lys Lys Ser Glu Glu Asp His Thr Glu Glu Ile Asn Asp Lys 
            100                 105                 110         


Ile Tyr Ser Leu Asn Tyr Asn Glu Leu Glu Val Leu Ala Lys Asn Gly 
        115                 120                 125             


Glu Thr Ile Glu Asn Phe Val Pro Lys Glu Gly Val Lys Lys Ala Asp 
    130                 135                 140                 


Lys Phe Ile Val Ile Glu Arg Lys Lys Lys Asn Ile Asn Thr Thr Pro 
145                 150                 155                 160 


Val Asp Ile Ser Ile Ile Asp Ser Val Thr Asp Arg Thr Tyr Pro Ala 
                165                 170                 175     


Ala Leu Gln Leu Ala Asn Lys Gly Phe Thr Glu Asn Lys Pro Asp Ala 
            180                 185                 190         


Val Val Thr Lys Arg Asn Pro Gln Lys Ile His Ile Asp Leu Pro Gly 
        195                 200                 205             


Met Gly Asp Lys Ala Thr Val Glu Val Asn Asp Pro Thr Tyr Ala Asn 
    210                 215                 220                 


Val Ser Thr Ala Ile Asp Asn Leu Val Asn Gln Trp His Asp Asn Tyr 
225                 230                 235                 240 


Ser Gly Gly Asn Thr Leu Pro Ala Arg Thr Gln Tyr Thr Glu Ser Met 
                245                 250                 255     


Val Tyr Ser Lys Ser Gln Ile Glu Ala Ala Leu Asn Val Asn Ser Lys 
            260                 265                 270         


Ile Leu Asp Gly Thr Leu Gly Ile Asp Phe Lys Ser Ile Ser Lys Gly 
        275                 280                 285             


Glu Lys Lys Val Met Ile Ala Ala Tyr Lys Gln Ile Phe Tyr Thr Val 
    290                 295                 300                 


Ser Ala Asn Leu Pro Asn Asn Pro Ala Asp Val Phe Asp Lys Ser Val 
305                 310                 315                 320 


Thr Phe Lys Asp Leu Gln Arg Lys Gly Val Ser Asn Glu Ala Pro Pro 
                325                 330                 335     


Leu Phe Val Ser Asn Val Ala Tyr Gly Arg Thr Val Phe Val Lys Leu 
            340                 345                 350         


Glu Thr Ser Ser Lys Ser Asn Asp Val Glu Ala Ala Phe Ser Ala Ala 
        355                 360                 365             


Leu Lys Gly Thr Asp Val Lys Thr Asn Gly Lys Tyr Ser Asp Ile Leu 
    370                 375                 380                 


Glu Asn Ser Ser Phe Thr Ala Val Val Leu Gly Gly Asp Ala Ala Glu 
385                 390                 395                 400 


His Asn Lys Val Val Thr Lys Asp Phe Asp Val Ile Arg Asn Val Ile 
                405                 410                 415     


Lys Asp Asn Ala Thr Phe Ser Arg Lys Asn Pro Ala Tyr Pro Ile Ser 
            420                 425                 430         


Tyr Thr Ser Val Phe Leu Lys Asn Asn Lys Ile Ala Gly Val Asn Asn 
        435                 440                 445             


Arg Thr Glu Tyr Val Glu Thr Thr Ser Thr Glu Tyr Thr Ser Gly Lys 
    450                 455                 460                 


Ile Asn Leu Ser His Gln Gly Ala Tyr Val Ala Gln Tyr Glu Ile Leu 
465                 470                 475                 480 


Trp Asp Glu Ile Asn Tyr Asp Asp Lys Gly Lys Glu Val Ile Thr Lys 
                485                 490                 495     


Arg Arg Trp Asp Asn Asn Trp Tyr Ser Lys Thr Ser Pro Phe Ser Thr 
            500                 505                 510         


Val Ile Pro Leu Gly Ala Asn Ser Arg Asn Ile Arg Ile Met Ala Arg 
        515                 520                 525             


Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Lys Val Ile Asp Glu 
    530                 535                 540                 


Arg Asp Val Lys Leu Ser Lys Glu Ile Asn Val Asn Ile Ser Gly Ser 
545                 550                 555                 560 


Thr Leu Ser Pro Tyr Gly Ser Ile Thr Tyr Lys 
                565                 570     


<210>  4
<211>  500
<212>  PRT
<213>  Clostridium perfringens

<400>  4

Met Ile Arg Phe Lys Lys Thr Lys Leu Ile Ala Ser Ile Ala Met Ala 
1               5                   10                  15      


Leu Cys Leu Phe Ser Gln Pro Val Ile Ser Phe Ser Lys Asp Ile Thr 
            20                  25                  30          


Asp Lys Asn Gln Ser Ile Asp Ser Gly Ile Ser Ser Leu Ser Tyr Asn 
        35                  40                  45              


Arg Asn Glu Val Leu Ala Ser Asn Gly Asp Lys Ile Glu Ser Phe Val 
    50                  55                  60                  


Pro Lys Glu Gly Lys Lys Thr Gly Asn Lys Phe Ile Val Val Glu Arg 
65                  70                  75                  80  


Gln Lys Arg Ser Leu Thr Thr Ser Pro Val Asp Ile Ser Ile Ile Asp 
                85                  90                  95      


Ser Val Asn Asp Arg Thr Tyr Pro Gly Ala Leu Gln Leu Ala Asp Lys 
            100                 105                 110         


Ala Phe Val Glu Asn Arg Pro Thr Ile Leu Met Val Lys Arg Lys Pro 
        115                 120                 125             


Ile Asn Ile Asn Ile Asp Leu Pro Gly Leu Lys Gly Glu Asn Ser Ile 
    130                 135                 140                 


Lys Val Asp Asp Pro Thr Tyr Gly Lys Val Ser Gly Ala Ile Asp Glu 
145                 150                 155                 160 


Leu Val Ser Lys Trp Asn Glu Lys Tyr Ser Ser Thr His Thr Leu Pro 
                165                 170                 175     


Ala Arg Thr Gln Tyr Ser Glu Ser Met Val Tyr Ser Lys Ser Gln Ile 
            180                 185                 190         


Ser Ser Ala Leu Asn Val Asn Ala Lys Val Leu Glu Asn Ser Leu Gly 
        195                 200                 205             


Val Asp Phe Asn Ala Val Ala Asn Asn Glu Lys Lys Val Met Ile Leu 
    210                 215                 220                 


Ala Tyr Lys Gln Ile Phe Tyr Thr Val Ser Ala Asp Leu Pro Lys Asn 
225                 230                 235                 240 


Pro Ser Asp Leu Phe Asp Asp Ser Val Thr Phe Asn Asp Leu Lys Gln 
                245                 250                 255     


Lys Gly Val Ser Asn Glu Ala Pro Pro Leu Met Val Ser Asn Val Ala 
            260                 265                 270         


Tyr Gly Arg Thr Ile Tyr Val Lys Leu Glu Thr Thr Ser Ser Ser Lys 
        275                 280                 285             


Asp Val Gln Ala Ala Phe Lys Ala Leu Ile Lys Asn Thr Asp Ile Lys 
    290                 295                 300                 


Asn Ser Gln Gln Tyr Lys Asp Ile Tyr Glu Asn Ser Ser Phe Thr Ala 
305                 310                 315                 320 


Val Val Leu Gly Gly Asp Ala Gln Glu His Asn Lys Val Val Thr Lys 
                325                 330                 335     


Asp Phe Asp Glu Ile Arg Lys Val Ile Lys Asp Asn Ala Thr Phe Ser 
            340                 345                 350         


Thr Lys Asn Pro Ala Tyr Pro Ile Ser Tyr Thr Ser Val Phe Leu Lys 
        355                 360                 365             


Asp Asn Ser Val Ala Ala Val His Asn Lys Thr Asp Tyr Ile Glu Thr 
    370                 375                 380                 


Thr Ser Thr Glu Tyr Ser Lys Gly Lys Ile Asn Leu Asp His Ser Gly 
385                 390                 395                 400 


Ala Tyr Val Ala Gln Phe Glu Val Ala Trp Asp Glu Val Ser Tyr Asp 
                405                 410                 415     


Lys Glu Gly Asn Glu Val Leu Thr His Lys Thr Trp Asp Gly Asn Tyr 
            420                 425                 430         


Gln Asp Lys Thr Ala His Tyr Ser Thr Val Ile Pro Leu Glu Ala Asn 
        435                 440                 445             


Ala Arg Asn Ile Arg Ile Lys Ala Arg Glu Cys Thr Gly Leu Ala Trp 
    450                 455                 460                 


Glu Trp Trp Arg Asp Val Ile Ser Glu Tyr Asp Val Pro Leu Thr Asn 
465                 470                 475                 480 


Asn Ile Asn Val Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gly Ser Ser 
                485                 490                 495     


Ile Thr Tyr Asn 
            500 


<210>  5
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  5

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  6
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly 
                325                 330                 335     


Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala 
            340                 345                 350         


Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys 
        355                 360                 365             


Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val 
    370                 375                 380                 


Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro 
385                 390                 395                 400 


Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr 
                405                 410                 415     


Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg 
            420                 425                 430         


Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly 
        435                 440                 445             


Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu 
    450                 455                 460                 


Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu 
465                 470                 475                 480 


Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn 
                485                 490                 495     


Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met 
            500                 505                 510         


Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser 
        515                 520                 525             


Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile 
    530                 535                 540             


<210>  7
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro 
            20                  25                  30          


Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro 
        35                  40                  45              


Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn 
    50                  55                  60                  


Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu 
65                  70                  75                  80  


Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly 
                85                  90                  95      


Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe 
            100                 105                 110         


Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys 
        115                 120                 125             


Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp 
    130                 135                 140                 


Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe 
145                 150                 155                 160 


Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe 
                165                 170                 175     


Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu 
            180                 185                 190         


Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu 
        195                 200                 205             


Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn 
    210                 215                 220                 


Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser 
225                 230                 235                 240 


Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser 
                245                 250                 255     


Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg 
            260                 265                 270         


Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu 
        275                 280                 285             


Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr 
    290                 295                 300                 


Ala Thr Lys Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile 
305                 310                 315                 320 


Ser Ser Val Gln Lys Val Phe Gln Asp Tyr Trp Leu Ser Leu Leu Phe 
                325                 330                 335     


Lys Lys Leu Val Gly Thr Lys Val Leu Met Ala Ser Val Gln Gly Ser 
            340                 345                 350         


Lys Arg Arg Lys Leu Arg Val Tyr Leu His Cys Thr Asn Thr Asp Asn 
        355                 360                 365             


Pro Arg Tyr Lys Glu Gly Asp Leu Thr Leu Tyr Ala Ile Asn Leu His 
    370                 375                 380                 


Asn Val Thr Lys Tyr Leu Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln 
385                 390                 395                 400 


Val Asp Lys Tyr Leu Leu Arg Pro Leu Gly Pro His Gly Leu Leu Ser 
                405                 410                 415     


Lys Ser Val Gln Leu Asn Gly Leu Thr Leu Lys Met Val Asp Asp Gln 
            420                 425                 430         


Thr Leu Pro Pro Leu Met Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu 
        435                 440                 445             


Gly Leu Pro Ala Phe Ser Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys 
    450                 455                 460                 


Val Ala Ala Cys Ile 
465                 


<210>  8
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys 
1               5                   10                  15      


Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser 
            20                  25                  30          


Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys 
        35                  40                  45              


Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn 
    50                  55                  60                  


Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly 
65                  70                  75                  80  


Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala 
                85                  90                  95      


Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val 
            100                 105                 110         


Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val 
        115                 120                 125             


Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser 
    130                 135                 140                 


Gly Leu Thr Leu Gln Ser Asn Ala Pro Ser Ser Met Met Val Lys Asp 
145                 150                 155                 160 


Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Ser Thr Glu Gly 
                165                 170                 175     


His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr 
            180                 185                 190         


Glu Thr Tyr Ser Thr Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala 
        195                 200                 205             


Thr Ser Thr Ala Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln 
    210                 215                 220                 


Pro Ala Ser Ile Leu Gly Gly Ser His Ser Glu Gly Leu Leu Gln Ile 
225                 230                 235                 240 


Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Gly Gln 
                245                 250                 255     


Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg 
            260                 265                 270         


Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu 
        275                 280                 285             


Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val 
    290                 295                 300                 


His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro 
305                 310                 315                 320 


Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly 
                325                 330                 335     


Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly 
            340                 345                 350         


Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser 
        355                 360                 365             


Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly 
    370                 375                 380                 


Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg 
385                 390                 395                 400 


Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg 
                405                 410                 415     


Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser 
            420                 425                 430         


Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln 
        435                 440                 445             


Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala 
    450                 455                 460                 


Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro 
465                 470                 475                 480 


Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg 
                485                 490                 495     


Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp 
            500                 505                 510         


Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His 
        515                 520                 525             


Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro 
    530                 535                 540                 


Ile Ala Asp Pro Gln Pro Leu Asp 
545                 550         


<210>  9
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Thr Asp 
        755                 760                 765             


Pro Thr Ala Pro Pro Tyr Asp Thr Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Thr Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210>  10
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Gly Arg Gly Glu Arg Gly Ser Gln 
        755                 760                 765             


Arg Gly Asn Gly Gly Leu Gln Leu Ala Arg Gly Arg Thr Arg Arg Ser 
    770                 775                 780                 


<210>  11
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Cys Pro Gly Gln Glu Pro Ala Leu Phe Ser Thr Asp Asn Asp 
1               5                   10                  15      


Asp Phe Thr Val Arg Asn Gly Glu Thr Val Gln Glu Arg Arg Ser Leu 
            20                  25                  30          


Lys Glu Arg Asn Pro Leu Lys Ile Phe Pro Ser Lys Arg Ile Leu Arg 
        35                  40                  45              


Arg His Lys Arg Asp Trp Val Val Ala Pro Ile Ser Val Pro Glu Asn 
    50                  55                  60                  


Gly Lys Gly Pro Phe Pro Gln Arg Leu Asn Gln Leu Lys Ser Asn Lys 
65                  70                  75                  80  


Asp Arg Asp Thr Lys Ile Phe Tyr Ser Ile Thr Gly Pro Gly Ala Asp 
                85                  90                  95      


Ser Pro Pro Glu Gly Val Phe Ala Val Glu Lys Glu Thr Gly Trp Leu 
            100                 105                 110         


Leu Leu Asn Lys Pro Leu Asp Arg Glu Glu Ile Ala Lys Tyr Glu Leu 
        115                 120                 125             


Phe Gly His Ala Val Ser Glu Asn Gly Ala Ser Val Glu Asp Pro Met 
    130                 135                 140                 


Asn Ile Ser Ile Ile Val Thr Asp Gln Asn Asp His Lys Pro Lys Phe 
145                 150                 155                 160 


Thr Gln Asp Thr Phe Arg Gly Ser Val Leu Glu Gly Val Leu Pro Gly 
                165                 170                 175     


Thr Ser Val Met Gln Val Thr Ala Thr Asp Glu Asp Asp Ala Ile Tyr 
            180                 185                 190         


Thr Tyr Asn Gly Val Val Ala Tyr Ser Ile His Ser Gln Glu Pro Lys 
        195                 200                 205             


Asp Pro His Asp Leu Met Phe Thr Ile His Arg Ser Thr Gly Thr Ile 
    210                 215                 220                 


Ser Val Ile Ser Ser Gly Leu Asp Arg Glu Lys Val Pro Glu Tyr Thr 
225                 230                 235                 240 


Leu Thr Ile Gln Ala Thr Asp Met Asp Gly Asp Gly Ser Thr Thr Thr 
                245                 250                 255     


Ala Val Ala Val Val Glu Ile Leu Asp Ala Asn Asp Asn Ala Pro Met 
            260                 265                 270         


Phe Asp Pro Gln Lys Tyr Glu Ala His Val Pro Glu Asn Ala Val Gly 
        275                 280                 285             


His Glu Val Gln Arg Leu Thr Val Thr Asp Leu Asp Ala Pro Asn Ser 
    290                 295                 300                 


Pro Ala Trp Arg Ala Thr Tyr Leu Ile Met Gly Gly Asp Asp Gly Asp 
305                 310                 315                 320 


His Phe Thr Ile Thr Thr His Pro Glu Ser Asn Gln Gly Ile Leu Thr 
                325                 330                 335     


Thr Arg Lys Gly Leu Asp Phe Glu Ala Lys Asn Gln His Thr Leu Tyr 
            340                 345                 350         


Val Glu Val Thr Asn Glu Ala Pro Phe Val Leu Lys Leu Pro Thr Ser 
        355                 360                 365             


Thr Ala Thr Ile Val Val His Val Glu Asp Val Asn Glu Ala Pro Val 
    370                 375                 380                 


Phe Val Pro Pro Ser Lys Val Val Glu Val Gln Glu Gly Ile Pro Thr 
385                 390                 395                 400 


Gly Glu Pro Val Cys Val Tyr Thr Ala Glu Asp Pro Asp Lys Glu Asn 
                405                 410                 415     


Gln Lys Ile Ser Tyr Arg Ile Leu Arg Asp Pro Ala Gly Trp Leu Ala 
            420                 425                 430         


Met Asp Pro Asp Ser Gly Gln Val Thr Ala Val Gly Thr Leu Asp Arg 
        435                 440                 445             


Glu Asp Glu Gln Phe Val Arg Asn Asn Ile Tyr Glu Val Met Val Leu 
    450                 455                 460                 


Ala Met Asp Asn Gly Ser Pro Pro Thr Thr Gly Thr Gly Thr Leu Leu 
465                 470                 475                 480 


Leu Thr Leu Ile Asp Val Asn Asp His Gly Pro Val Pro Glu Pro Arg 
                485                 490                 495     


Gln Ile Thr Ile Cys Asn Gln Ser Pro Val Arg Gln Val Leu Asn Ile 
            500                 505                 510         


Thr Asp Lys Asp Leu Ser Pro His Thr Ser Pro Phe Gln Ala Gln Leu 
        515                 520                 525             


Thr Asp Asp Ser Asp Ile Tyr Trp Thr Ala Glu Val Asn Glu Glu Gly 
    530                 535                 540                 


Asp Thr Val Val Leu Ser Leu Lys Lys Phe Leu Lys Gln Asp Thr Tyr 
545                 550                 555                 560 


Asp Val His Leu Ser Leu Ser Asp His Gly Asn Lys Glu Gln Leu Thr 
                565                 570                 575     


Val Ile Arg Ala Thr Val Cys Asp Cys His Gly His Val Glu Thr Cys 
            580                 585                 590         


Pro Gly Pro Trp Lys Gly Gly Phe Ile Leu Pro Val Leu Gly Ala Val 
        595                 600                 605             


Leu Ala Leu Leu Phe Leu Leu Leu Val Leu Leu Leu Leu Val Arg Lys 
    610                 615                 620                 


Lys Arg Lys Ile Lys Glu Pro Leu Leu Leu Pro Glu Asp Asp Thr Arg 
625                 630                 635                 640 


Asp Asn Val Phe Tyr Tyr Gly Glu Glu Gly Gly Gly Glu Glu Asp Gln 
                645                 650                 655     


Asp Tyr Asp Ile Thr Gln Leu His Arg Gly Leu Glu Ala Arg Pro Glu 
            660                 665                 670         


Val Val Leu Arg Asn Asp Val Ala Pro Thr Ile Ile Pro Thr Pro Met 
        675                 680                 685             


Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Ala Asn Thr Asp Pro Thr Ala Pro Pro Tyr Asp 
705                 710                 715                 720 


Thr Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Asp Ala Ala Ser 
                725                 730                 735     


Leu Ser Ser Leu Thr Ser Ser Ala Ser Asp Gln Asp Gln Asp Tyr Asp 
            740                 745                 750         


Tyr Leu Asn Glu Trp Gly Ser Arg Phe Lys Lys Leu Ala Asp Met Tyr 
        755                 760                 765             


Gly Gly Gly Glu Asp Asp 
    770                 


<210>  12
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  13
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  14
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Met Trp Gln Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly 
1               5                   10                  15      


Ala Arg Ile Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala Ile 
            20                  25                  30          


Val Tyr Tyr Leu Ile Gln Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys 
        35                  40                  45              


Leu Ala Val Glu Gln Leu Gln Ser His Pro Glu Ala Gln Glu Ala Leu 
    50                  55                  60                  


Gly Pro Pro Leu Asn Ile His Tyr Leu Lys Leu Ile Asp Arg Glu Asn 
65                  70                  75                  80  


Phe Val Asp Ile Val Asp Ala Lys Leu Lys Ile Pro Val Ser Gly Ser 
                85                  90                  95      


Lys Ser Glu Gly Leu Leu Tyr Val His Ser Ser Arg Gly Gly Pro Phe 
            100                 105                 110         


Gln Arg Trp His Leu Asp Glu Val Phe Leu Glu Leu Lys Asp Gly Gln 
        115                 120                 125             


Gln Ile Pro Val Phe Lys Leu Ser Gly Glu Asn Gly Asp Glu Val Lys 
    130                 135                 140                 


Lys Glu 
145     


<210>  15
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Leu Gly Ala Arg Ile Leu Phe His Gly Val Phe Tyr Ala Gly 
1               5                   10                  15      


Gly Phe Ala Ile Val Tyr Tyr Leu Ile Gln Lys Phe His Ser Arg Ala 
            20                  25                  30          


Leu Tyr Tyr Lys Leu Ala Val Glu Gln Leu Gln Ser His Pro Glu Ala 
        35                  40                  45              


Gln Glu Ala Leu Gly Pro Pro Leu Asn Ile His Tyr Leu Lys Leu Ile 
    50                  55                  60                  


Asp Arg Glu Asn Phe Val Asp Ile Val Asp Ala Lys Leu Lys Ile Pro 
65                  70                  75                  80  


Val Ser Gly Ser Lys Ser Glu Gly Leu Leu Tyr Val His Ser Ser Arg 
                85                  90                  95      


Gly Gly Pro Phe Gln Arg Trp His Leu Asp Glu Val Phe Leu Glu Leu 
            100                 105                 110         


Lys Asp Gly Gln Gln Ile Pro Val Phe Lys Leu Ser Gly Glu Asn Gly 
        115                 120                 125             


Asp Glu Val Lys Lys Glu 
    130                 


<210>  16
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Met Trp Gln Lys Tyr Ala Gly Ser Arg Arg Ser Met Pro Leu Gly 
1               5                   10                  15      


Ala Arg Ile Leu Phe His Gly Val Phe Tyr Ala Gly Gly Phe Ala Ile 
            20                  25                  30          


Val Tyr Tyr Leu Ile Gln Ser Lys Tyr Pro Ala Ser Arg Leu Arg Pro 
        35                  40                  45              


Asp Leu Leu Leu Ala Cys Ser Cys Ser Ser Ile Arg Gly Asn Thr 
    50                  55                  60              


<210>  17
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gln Glu Ala Gly Gly Gln Cys Leu Trp Glu Gln Gly Ser Phe Ser 
1               5                   10                  15      


Thr Val Cys Ser Met Pro Gly Ala Leu Pro Leu Cys Ile Thr Ser Phe 
            20                  25                  30          


Lys Phe His Ser Arg Ala Leu Tyr Tyr Lys Leu Ala Val Glu Gln Leu 
        35                  40                  45              


Gln Ser His Pro Glu Ala Gln Glu Ala Leu Gly Pro Pro Leu Asn Ile 
    50                  55                  60                  


His Tyr Leu Lys Leu Ile Asp Arg Glu Asn Phe Val Asp Ile Val Asp 
65                  70                  75                  80  


Ala Lys Leu Lys Ile Pro Val Ser Gly Ser Lys Ser Glu Gly Leu Leu 
                85                  90                  95      


Tyr Val His Ser Ser Arg Gly Gly Pro Phe Gln Arg Trp His Leu Asp 
            100                 105                 110         


Glu Val Phe Leu Glu Leu Lys Asp Gly Gln Gln Ile Pro Val Phe Lys 
        115                 120                 125             


Leu Ser Gly Glu Asn Gly Asp Glu Val Lys Lys Glu 
    130                 135                 140 


<210>  18
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ile Thr Gln Phe Arg Leu Phe Lys Phe Cys Thr Cys Leu Ala 
1               5                   10                  15      


Thr Val Phe Ser Phe Leu Lys Arg Leu Ile Cys Arg Ser Gly Arg Gly 
            20                  25                  30          


Arg Lys Leu Ser Gly Asp Gln Ile Thr Leu Pro Thr Thr Val Asp Tyr 
        35                  40                  45              


Ser Ser Val Pro Lys Gln Thr Asp Val Glu Glu Trp Thr Ser Trp Asp 
    50                  55                  60                  


Glu Asp Ala Pro Thr Ser Val Lys Ile Glu Gly Gly Asn Gly Asn Val 
65                  70                  75                  80  


Ala Thr Gln Gln Asn Ser Leu Glu Gln Leu Glu Pro Asp Tyr Phe Lys 
                85                  90                  95      


Asp Met Thr Pro Thr Ile Arg Lys Thr Gln Lys Ile Val Ile Lys Lys 
            100                 105                 110         


Arg Glu Pro Leu Asn Phe Gly Ile Pro Asp Gly Ser Thr Gly Phe Ser 
        115                 120                 125             


Ser Arg Leu Ala Ala Thr Gln Asp Leu Pro Phe Ile His Gln Ser Ser 
    130                 135                 140                 


Glu Leu Gly Asp Leu Asp Thr Trp Gln Glu Asn Thr Asn Ala Trp Glu 
145                 150                 155                 160 


Glu Glu Glu Asp Ala Ala Trp Gln Ala Glu Glu Val Leu Arg Gln Gln 
                165                 170                 175     


Lys Leu Ala Asp Arg Glu Lys Arg Ala Ala Glu Gln Gln Arg Lys Lys 
            180                 185                 190         


Met Glu Lys Glu Ala Gln Arg Leu Met Lys Lys Glu Gln Asn Lys Ile 
        195                 200                 205             


Gly Val Lys Leu Ser 
    210             


<210>  19
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Gln 
1               5                   10                  15      


Lys Pro Gln Asn Lys His Met Ile Cys Trp Thr Ser Asn Asp Gly Gln 
            20                  25                  30          


Phe Lys Leu Leu Gln Ala Glu Glu Val Ala Arg Leu Trp Gly Ile Arg 
        35                  40                  45              


Lys Asn Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
    50                  55                  60                  


Tyr Tyr Tyr Val Lys Asn Ile Ile Lys Lys Val Asn Gly Gln Lys Phe 
65                  70                  75                  80  


Val Tyr Lys Phe Val Ser Tyr Pro Glu Ile Leu Asn Met Asp Pro Met 
                85                  90                  95      


Thr Val Gly Arg Ile Glu Gly Asp Cys Glu Ser Leu Asn Phe Ser Glu 
            100                 105                 110         


Val Ser Ser Ser Ser Lys Asp Val Glu Asn Gly Gly Lys Asp Lys Pro 
        115                 120                 125             


Pro Gln Pro Gly Ala Lys Thr Ser Ser Arg Asn Asp Tyr Ile His Ser 
    130                 135                 140                 


Gly Leu Tyr Ser Ser Phe Thr Leu Asn Ser Leu Asn Ser Ser Asn Val 
145                 150                 155                 160 


Lys Leu Phe Lys Leu Ile Lys Thr Glu Asn Pro Ala Glu Lys Leu Ala 
                165                 170                 175     


Glu Lys Lys Ser Pro Gln Glu Pro Thr Pro Ser Val Ile Lys Phe Val 
            180                 185                 190         


Thr Thr Pro Ser Lys Lys Pro Pro Val Glu Pro Val Ala Ala Thr Ile 
        195                 200                 205             


Ser Ile Gly Pro Ser Ile Ser Pro Ser Ser Glu Glu Thr Ile Gln Ala 
    210                 215                 220                 


Leu Glu Thr Leu Val Ser Pro Lys Leu Pro Ser Leu Glu Ala Pro Thr 
225                 230                 235                 240 


Ser Ala Ser Asn Val Met Thr Ala Phe Ala Thr Thr Pro Pro Ile Ser 
                245                 250                 255     


Ser Ile Pro Pro Leu Gln Glu Pro Pro Arg Thr Pro Ser Pro Pro Leu 
            260                 265                 270         


Ser Ser His Pro Asp Ile Asp Thr Asp Ile Asp Ser Val Ala Ser Gln 
        275                 280                 285             


Pro Met Glu Leu Pro Glu Asn Leu Ser Leu Glu Pro Lys Asp Gln Asp 
    290                 295                 300                 


Ser Val Leu Leu Glu Lys Asp Lys Val Asn Asn Ser Ser Arg Ser Lys 
305                 310                 315                 320 


Lys Pro Lys Gly Leu Glu Leu Ala Pro Thr Leu Val Ile Thr Ser Ser 
                325                 330                 335     


Asp Pro Ser Pro Leu Gly Ile Leu Ser Pro Ser Leu Pro Thr Ala Ser 
            340                 345                 350         


Leu Thr Pro Ala Phe Phe Ser Gln Thr Pro Ile Ile Leu Thr Pro Ser 
        355                 360                 365             


Pro Leu Leu Ser Ser Ile His Phe Trp Ser Thr Leu Ser Pro Val Ala 
    370                 375                 380                 


Pro Leu Ser Pro Ala Arg Leu Gln Gly Ala Asn Thr Leu Phe Gln Phe 
385                 390                 395                 400 


Pro Ser Val Leu Asn Ser His Gly Pro Phe Thr Leu Ser Gly Leu Asp 
                405                 410                 415     


Gly Pro Ser Thr Pro Gly Pro Phe Ser Pro Asp Leu Gln Lys Thr 
            420                 425                 430     


<210>  20
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Gln 
1               5                   10                  15      


Lys Pro Gln Asn Lys His Met Ile Cys Trp Thr Ser Asn Asp Gly Gln 
            20                  25                  30          


Phe Lys Leu Leu Gln Ala Glu Glu Val Ala Arg Leu Trp Gly Ile Arg 
        35                  40                  45              


Lys Asn Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg 
    50                  55                  60                  


Tyr Tyr Tyr Val Lys Asn Ile Ile Lys Lys Val Asn Gly Gln Lys Phe 
65                  70                  75                  80  


Val Tyr Lys Phe Val Ser Tyr Pro Glu Ile Leu Asn Met Asp Pro Met 
                85                  90                  95      


Thr Val Gly Arg Ile Glu Gly Asp Cys Glu Ser Leu Asn Phe Ser Glu 
            100                 105                 110         


Val Ser Ser Ser Ser Lys Asp Val Glu Asn Gly Gly Lys Asp Lys Pro 
        115                 120                 125             


Pro Gln Pro Gly Ala Lys Thr Ser Ser Arg Asn Asp Tyr Ile His Ser 
    130                 135                 140                 


Gly Leu Tyr Ser Ser Phe Thr Leu Asn Ser Leu Asn Ser Ser Asn Val 
145                 150                 155                 160 


Lys Leu Phe Lys Leu Ile Lys Thr Glu Asn Pro Ala Glu Lys Leu Ala 
                165                 170                 175     


Glu Lys Lys Ser Pro Gln Glu Pro Thr Pro Ser Val Ile Lys Phe Val 
            180                 185                 190         


Thr Thr Pro Ser Lys Lys Pro Pro Val Glu Pro Val Ala Ala Thr Ile 
        195                 200                 205             


Ser Ile Gly Pro Ser Ile Ser Pro Ser Ser Glu Glu Thr Ile Gln Ala 
    210                 215                 220                 


Leu Glu Thr Leu Val Ser Pro Lys Leu Pro Ser Leu Glu Ala Pro Thr 
225                 230                 235                 240 


Ser Ala Ser Asn Val Met Thr Ala Phe Ala Thr Thr Pro Pro Ile Ser 
                245                 250                 255     


Ser Ile Pro Pro Leu Gln Glu Pro Pro Arg Thr Pro Ser Pro Pro Leu 
            260                 265                 270         


Ser Ser His Pro Asp Ile Asp Thr Asp Ile Asp Ser Val Ala Ser Gln 
        275                 280                 285             


Pro Met Glu Leu Pro Glu Asn Leu Ser Leu Glu Pro Lys Asp Gln Asp 
    290                 295                 300                 


Ser Val Leu Leu Glu Lys Asp Lys Val Asn Asn Ser Ser Arg Ser Lys 
305                 310                 315                 320 


Lys Pro Lys Gly Leu Glu Leu Ala Pro Thr Leu Val Ile Thr Ser Ser 
                325                 330                 335     


Asp Pro Ser Pro Leu Gly Ile Leu Ser Pro Ser Leu Pro Thr Ala Ser 
            340                 345                 350         


Leu Thr Pro Ala Phe Phe Ser Gln Val Ala Cys Ser Leu Phe Met Val 
        355                 360                 365             


Ser Pro Leu Leu Ser Phe Ile Cys Pro Phe Lys Gln Ile Gln Asn Leu 
    370                 375                 380                 


Tyr Thr Gln Val Cys Phe Leu Leu Leu Arg Phe Val Leu Glu Arg Leu 
385                 390                 395                 400 


Cys Val Thr Val Met 
                405 


<210>  21
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  22
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  23
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 
1               5                   10                  15      


Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 
            20                  25                  30          


His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 
        35                  40                  45              


Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 
    50                  55                  60                  


Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 
65                  70                  75                  80  


Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
                85                  90                  95      


Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 
            100                 105                 110         


Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 
        115                 120                 125             


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 
    130                 135                 140                 


Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 
145                 150                 155                 160 


Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 
                165                 170                 175     


Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 
            180                 185                 190         


Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 
        195                 200                 205             


Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 
    210                 215                 220                 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
225                 230                 235                 240 


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
                245                 250                 255     


Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 
            260                 265                 270         


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 
        275                 280                 285             


Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 
    290                 295                 300                 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
305                 310                 315                 320 


Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
                325                 330                 335     


Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 
            340                 345                 350         


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
        355                 360                 365             


Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 
    370                 375                 380                 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
385                 390                 395                 400 


Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 
                405                 410                 415     


Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
            420                 425                 430         


Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
        435                 440                 445             


Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 
    450                 455                 460                 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
465                 470                 475                 480 


Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 
                485                 490                 495     


His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
            500                 505                 510         


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
        515                 520                 525             


Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 
    530                 535                 540                 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 
545                 550                 555                 560 


Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 
                565                 570                 575     


Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
            580                 585                 590         


Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 
        595                 600                 605             


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 
    610                 615                 620                 


Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 
625                 630                 635                 640 


Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 
                645                 650                 655     


Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665                 670         


Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 
        675                 680                 685             


Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 
    690                 695                 700                 


Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
705                 710                 715                 720 


Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 
                725                 730                 735     


Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 
            740                 745                 750         


Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 
        755                 760                 765             


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 
    770                 775                 780                 


Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 
785                 790                 795                 800 


Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 
                805                 810                 815     


Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 
            820                 825                 830         


Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 
        835                 840                 845             


Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 
    850                 855                 860                 


Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
865                 870                 875                 880 


Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
                885                 890                 895     


Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 
            900                 905                 910         


Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 
        915                 920                 925             


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
    930                 935                 940                 


Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 
945                 950                 955                 960 


Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 
                965                 970                 975     


Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 
            980                 985                 990         


Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
        995                 1000                 1005             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1010                 1015                 1020             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1025                 1030                 1035             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1040                 1045                 1050             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1055                 1060                 1065             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1070                 1075                 1080             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1085                 1090                 1095             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1100                 1105                 1110             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1115                 1120                 1125             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1130                 1135                 1140             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1145                 1150                 1155             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1160                 1165                 1170             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1175                 1180                 1185             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1190                 1195                 1200             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1205                 1210                 1215             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Asp Val Pro Val  
    1235                 1240 


<210>  24
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Asn Met  
    1055 


<210>  25
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 
        595                 600             


<210>  26
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Ser Tyr Val Pro Asp Asp 
1               5                   10                  15      


Gly Leu Thr Ala Gln Gln Leu Phe Asn Cys Gly Asp Gly Leu Thr Tyr 
            20                  25                  30          


Asn Asp Phe Leu Ile Leu Pro Gly Tyr Ile Asp Phe Thr Ala Asp Gln 
        35                  40                  45              


Val Asp Leu Thr Ser Ala Leu Thr Lys Lys Ile Thr Leu Lys Thr Pro 
    50                  55                  60                  


Leu Val Ser Ser Pro Met Asp Thr Val Thr Glu Ala Gly Met Ala Ile 
65                  70                  75                  80  


Ala Met Ala Leu Thr Gly Gly Ile Gly Phe Ile His His Asn Cys Thr 
                85                  90                  95      


Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val Lys Lys Tyr Glu Gln 
            100                 105                 110         


Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro Lys Asp Arg Val Arg 
        115                 120                 125             


Asp Val Phe Glu Ala Lys Ala Arg His Gly Phe Cys Gly Ile Pro Ile 
    130                 135                 140                 


Thr Asp Thr Gly Arg Met Gly Ser Arg Leu Val Gly Ile Ile Ser Ser 
145                 150                 155                 160 


Arg Asp Ile Asp Phe Leu Lys Glu Glu Glu His Asp Cys Phe Leu Glu 
                165                 170                 175     


Glu Ile Met Thr Lys Arg Glu Asp Leu Val Val Ala Pro Ala Gly Ile 
            180                 185                 190         


Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys 
        195                 200                 205             


Leu Pro Ile Val Asn Glu Asp Asp Glu Leu Val Ala Ile Ile Ala Arg 
    210                 215                 220                 


Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ala 
225                 230                 235                 240 


Lys Lys Gln Leu Leu Cys Gly Ala Ala Ile Gly Thr His Glu Asp Asp 
                245                 250                 255     


Lys Tyr Arg Leu Asp Leu Leu Ala Gln Ala Gly Val Asp Val Val Val 
            260                 265                 270         


Leu Asp Ser Ser Gln Gly Asn Ser Ile Phe Gln Ile Asn Met Ile Lys 
        275                 280                 285             


Tyr Ile Lys Asp Lys Tyr Pro Asn Leu Gln Val Ile Gly Gly Asn Val 
    290                 295                 300                 


Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp Ala 
305                 310                 315                 320 


Leu Arg Val Gly Met Gly Ser Gly Ser Ile Cys Ile Thr Gln Glu Val 
                325                 330                 335     


Leu Ala Cys Gly Arg Pro Gln Ala Thr Ala Val Tyr Lys Val Ser Glu 
            340                 345                 350         


Tyr Ala Arg Arg Phe Gly Val Pro Val Ile Ala Asp Gly Gly Ile Gln 
        355                 360                 365             


Asn Val Gly His Ile Ala Lys Ala Leu Ala Leu Gly Ala Ser Thr Val 
    370                 375                 380                 


Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr 
385                 390                 395                 400 


Phe Phe Ser Asp Gly Ile Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser 
                405                 410                 415     


Leu Asp Ala Met Asp Lys His Leu Ser Ser Gln Asn Arg Tyr Phe Ser 
            420                 425                 430         


Glu Ala Asp Lys Ile Lys Val Ala Gln Gly Val Ser Gly Ala Val Gln 
        435                 440                 445             


Asp Lys Gly Ser Ile His Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile 
    450                 455                 460                 


Gln His Ser Cys Gln Asp Ile Gly Ala Lys Ser Leu Thr Gln Val Arg 
465                 470                 475                 480 


Ala Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Ser Ser 
                485                 490                 495     


Ala Gln Val Glu Gly Gly Val His Ser Leu His Ser Tyr Glu Lys Arg 
            500                 505                 510         


Leu Phe 
        


<210>  27
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  28
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  29
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  30
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  31
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
    770                 775                 780                 


Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 
785                 790                 795                 800 


Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 
                805                 810                 815     


Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
            820                 825                 830         


Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
        835                 840                 845             


Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala 
    850                 855                 860                 


Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
865                 870                 875                 880 


Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 
                885                 890                 895     


Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905                 910     


<210>  32
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Gly Thr Leu Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Cys Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Lys Gln Thr Gly Ser 
    770                 775                 780                 


Met Asp Ser Asp Asp Phe Arg Ala Leu Leu Ile Ser Thr Gly Tyr Ser 
785                 790                 795                 800 


Leu Gly Glu Ala Glu Phe Asn Arg Ile Met Ser Leu Val Asp Pro Asn 
                805                 810                 815     


His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile Asp Phe Met Ser Arg 
            820                 825                 830         


Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val Ile Ala Ser Phe Lys 
        835                 840                 845             


Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala Glu Glu Leu Arg Arg 
    850                 855                 860                 


Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met Ala Pro 
865                 870                 875                 880 


Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu Asp Tyr Lys Ser Phe 
                885                 890                 895     


Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905     


<210>  33
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Val Asp Gly Val Met Ile Leu Pro Val Leu Ile Met Ile Ala Leu 
1               5                   10                  15      


Pro Ser Pro Ser Met Glu Asp Glu Lys Pro Lys Val Asn Pro Lys Leu 
            20                  25                  30          


Tyr Met Cys Val Cys Glu Gly Leu Ser Cys Gly Asn Glu Asp His Cys 
        35                  40                  45              


Glu Gly Gln Gln Cys Phe Ser Ser Leu Ser Ile Asn Asp Gly Phe His 
    50                  55                  60                  


Val Tyr Gln Lys Gly Cys Phe Gln Val Tyr Glu Gln Gly Lys Met Thr 
65                  70                  75                  80  


Cys Lys Thr Pro Pro Ser Pro Gly Gln Ala Val Glu Cys Cys Gln Gly 
                85                  90                  95      


Asp Trp Cys Asn Arg Asn Ile Thr Ala Gln Leu Pro Thr Lys Gly Lys 
            100                 105                 110         


Ser Phe Pro Gly Thr Gln Asn Phe His Leu Glu Val Gly Leu Ile Ile 
        115                 120                 125             


Leu Ser Val Val Phe Ala Val Cys Leu Leu Ala Cys Leu Leu Gly Val 
    130                 135                 140                 


Ala Leu Arg Lys Phe Lys Arg Arg Asn Gln Glu Arg Leu Asn Pro Arg 
145                 150                 155                 160 


Asp Val Glu Tyr Gly Thr Ile Glu Gly Leu Ile Thr Thr Asn Val Gly 
                165                 170                 175     


Asp Ser Thr Leu Ala Asp Leu Leu Asp His Ser Cys Thr Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Leu Pro Phe Leu Val Gln Arg Thr Val Ala Arg Gln Ile 
        195                 200                 205             


Thr Leu Leu Glu Cys Val Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg 
    210                 215                 220                 


Gly Ser Trp Gln Gly Glu Asn Val Ala Val Lys Ile Phe Ser Ser Arg 
225                 230                 235                 240 


Asp Glu Lys Ser Trp Phe Arg Glu Thr Glu Leu Tyr Asn Thr Val Met 
                245                 250                 255     


Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ser Asp Met Thr Ser 
            260                 265                 270         


Arg His Ser Ser Thr Gln Leu Trp Leu Ile Thr His Tyr His Glu Met 
        275                 280                 285             


Gly Ser Leu Tyr Asp Tyr Leu Gln Leu Thr Thr Leu Asp Thr Val Ser 
    290                 295                 300                 


Cys Leu Arg Ile Val Leu Ser Ile Ala Ser Gly Leu Ala His Leu His 
305                 310                 315                 320 


Ile Glu Ile Phe Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp 
                325                 330                 335     


Leu Lys Ser Lys Asn Ile Leu Val Lys Lys Asn Gly Gln Cys Cys Ile 
            340                 345                 350         


Ala Asp Leu Gly Leu Ala Val Met His Ser Gln Ser Thr Asn Gln Leu 
        355                 360                 365             


Asp Val Gly Asn Asn Pro Arg Val Gly Thr Lys Arg Tyr Met Ala Pro 
    370                 375                 380                 


Glu Val Leu Asp Glu Thr Ile Gln Val Asp Cys Phe Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Val Asp Ile Trp Ala Phe Gly Leu Val Leu Trp Glu Val Ala Arg 
                405                 410                 415     


Arg Met Val Ser Asn Gly Ile Val Glu Asp Tyr Lys Pro Pro Phe Tyr 
            420                 425                 430         


Asp Val Val Pro Asn Asp Pro Ser Phe Glu Asp Met Arg Lys Val Val 
        435                 440                 445             


Cys Val Asp Gln Gln Arg Pro Asn Ile Pro Asn Arg Trp Phe Ser Asp 
    450                 455                 460                 


Pro Thr Leu Thr Ser Leu Ala Lys Leu Met Lys Glu Cys Trp Tyr Gln 
465                 470                 475                 480 


Asn Pro Ser Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Thr 
                485                 490                 495     


Lys Ile Asp Asn Ser Leu Asp Lys Leu Lys Thr Asp Cys 
            500                 505                 


<210>  34
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      


Glu Leu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          


Lys Ala His Glu Val Arg Ile Lys Met Val Ala Ala Gly Ile Cys Arg 
        35                  40                  45              


Ser Asp Glu His Val Val Ser Gly Asn Leu Val Thr Pro Leu Pro Val 
    50                  55                  60                  


Ile Leu Gly His Glu Ala Ala Gly Ile Val Glu Ser Val Gly Glu Gly 
65                  70                  75                  80  


Val Thr Thr Val Lys Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro 
                85                  90                  95      


Gln Cys Gly Lys Cys Arg Ile Cys Lys Asn Pro Glu Ser Asn Tyr Cys 
            100                 105                 110         


Leu Lys Asn Asp Leu Gly Asn Pro Arg Gly Thr Leu Gln Asp Gly Thr 
        115                 120                 125             


Arg Arg Phe Thr Cys Ser Gly Lys Pro Ile His His Phe Val Gly Val 
    130                 135                 140                 


Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Asn Ala Val Ala Lys 
145                 150                 155                 160 


Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     


Phe Ser Thr Gly Tyr Gly Ser Ala Val Lys Val Ala Lys Val Thr Pro 
            180                 185                 190         


Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val 
        195                 200                 205             


Val Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Ala Val Asp 
    210                 215                 220                 


Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Leu Gly Ala Thr Glu 
225                 230                 235                 240 


Cys Ile Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Lys 
                245                 250                 255     


Glu Met Thr Asp Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         


Leu Asp Thr Met Met Ala Ser Leu Leu Cys Cys His Glu Ala Cys Gly 
        275                 280                 285             


Thr Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Ile 
    290                 295                 300                 


Asn Pro Met Leu Leu Leu Thr Gly Arg Thr Trp Lys Gly Ala Ile Phe 
305                 310                 315                 320 


Gly Gly Phe Lys Ser Lys Glu Ser Val Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     


Met Ala Lys Lys Phe Ser Leu Asp Ala Leu Ile Thr Asn Ile Leu Pro 
            340                 345                 350         


Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu Arg Ser Gly Lys Ser 
        355                 360                 365             


Ile Arg Thr Val Leu Thr Phe 
    370                 375 


<210>  35
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Ile Met Gly Ser Ser Val Tyr Ile Thr Val Glu Leu Ala Ile 
1               5                   10                  15      


Ala Val Leu Ala Ile Leu Gly Asn Val Leu Val Cys Trp Ala Val Trp 
            20                  25                  30          


Leu Asn Ser Asn Leu Gln Asn Val Thr Asn Tyr Phe Val Val Ser Leu 
        35                  40                  45              


Ala Ala Ala Asp Ile Ala Val Gly Val Leu Ala Ile Pro Phe Ala Ile 
    50                  55                  60                  


Thr Ile Ser Thr Gly Phe Cys Ala Ala Cys His Gly Cys Leu Phe Ile 
65                  70                  75                  80  


Ala Cys Phe Val Leu Val Leu Thr Gln Ser Ser Ile Phe Ser Leu Leu 
                85                  90                  95      


Ala Ile Ala Ile Asp Arg Tyr Ile Ala Ile Arg Ile Pro Leu Arg Tyr 
            100                 105                 110         


Asn Gly Leu Val Thr Gly Thr Arg Ala Lys Gly Ile Ile Ala Ile Cys 
        115                 120                 125             


Trp Val Leu Ser Phe Ala Ile Gly Leu Thr Pro Met Leu Gly Trp Asn 
    130                 135                 140                 


Asn Cys Gly Gln Pro Lys Glu Gly Lys Asn His Ser Gln Gly Cys Gly 
145                 150                 155                 160 


Glu Gly Gln Val Ala Cys Leu Phe Glu Asp Val Val Pro Met Asn Tyr 
                165                 170                 175     


Met Val Tyr Phe Asn Phe Phe Ala Cys Val Leu Val Pro Leu Leu Leu 
            180                 185                 190         


Met Leu Gly Val Tyr Leu Arg Ile Phe Leu Ala Ala Arg Arg Gln Leu 
        195                 200                 205             


Lys Gln Met Glu Ser Gln Pro Leu Pro Gly Glu Arg Ala Arg Ser Thr 
    210                 215                 220                 


Leu Gln Lys Glu Val His Ala Ala Lys Ser Leu Ala Ile Ile Val Gly 
225                 230                 235                 240 


Leu Phe Ala Leu Cys Trp Leu Pro Leu His Ile Ile Asn Cys Phe Thr 
                245                 250                 255     


Phe Phe Cys Pro Asp Cys Ser His Ala Pro Leu Trp Leu Met Tyr Leu 
            260                 265                 270         


Ala Ile Val Leu Ser His Thr Asn Ser Val Val Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ala Tyr Arg Ile Arg Glu Phe Arg Gln Thr Phe Arg Lys Ile Ile Arg 
    290                 295                 300                 


Ser His Val Leu Arg Gln Gln Glu Pro Phe Lys Ala Ala Gly Thr Ser 
305                 310                 315                 320 


Ala Arg Val Leu Ala Ala His Gly Ser Asp Gly Glu Gln Val Ser Leu 
                325                 330                 335     


Arg Leu Asn Gly His Pro Pro Gly Val Trp Ala Asn Gly Ser Ala Pro 
            340                 345                 350         


His Pro Glu Arg Arg Pro Asn Gly Tyr Ala Leu Gly Leu Val Ser Gly 
        355                 360                 365             


Gly Ser Ala Gln Glu Ser Gln Gly Asn Thr Gly Leu Pro Asp Val Glu 
    370                 375                 380                 


Leu Leu Ser His Glu Leu Lys Gly Val Cys Pro Glu Pro Pro Gly Leu 
385                 390                 395                 400 


Asp Asp Pro Leu Ala Gln Asp Gly Ala Gly Val Ser 
                405                 410         


<210>  36
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Gln Arg His Ser Asp Ser Ser Leu Glu Glu Lys Leu Leu Gly 
1               5                   10                  15      


His Arg Phe His Ser Glu Leu Arg Leu Asp Ala Gly Gly Asn Pro Ala 
            20                  25                  30          


Ser Gly Leu Pro Met Val Arg Gly Ser Pro Arg Val Arg Asp Asp Ala 
        35                  40                  45              


Ala Phe Gln Pro Gln Val Pro Ala Pro Pro Gln Pro Arg Pro Pro Gly 
    50                  55                  60                  


His Glu Glu Pro Trp Pro Ile Val Leu Ser Thr Glu Ser Pro Ala Ala 
65                  70                  75                  80  


Leu Lys Leu Gly Thr Gln Gln Leu Ile Pro Lys Ser Leu Ala Val Ala 
                85                  90                  95      


Ser Lys Ala Lys Thr Pro Ala Arg His Gln Ser Phe Gly Ala Ala Val 
            100                 105                 110         


Leu Ser Arg Glu Ala Ala Arg Arg Asp Pro Lys Leu Leu Pro Ala Pro 
        115                 120                 125             


Ser Phe Ser Leu Asp Asp Met Asp Val Asp Lys Asp Pro Gly Gly Met 
    130                 135                 140                 


Leu Arg Arg Asn Leu Arg Asn Gln Ser Tyr Arg Ala Ala Met Lys Gly 
145                 150                 155                 160 


Leu Gly Lys Pro Gly Gly Gln Gly Asp Ala Ile Gln Leu Ser Pro Lys 
                165                 170                 175     


Leu Gln Ala Leu Ala Glu Glu Pro Ser Gln Pro His Thr Arg Ser Pro 
            180                 185                 190         


Ala Lys Asn Lys Lys Thr Leu Gly Arg Lys Arg Gly His Lys Gly Ser 
        195                 200                 205             


Phe Lys Asp Asp Pro Gln Leu Tyr Gln Glu Ile Gln Glu Arg Gly Leu 
    210                 215                 220                 


Asn Thr Ser Gln Glu Ser Asp Asp Asp Ile Leu Asp Glu Ser Ser Ser 
225                 230                 235                 240 


Pro Glu Gly Thr Gln Lys Val Asp Ala Thr Ile Val Val Lys Ser Tyr 
                245                 250                 255     


Arg Pro Ala Gln Val Thr Trp Ser Gln Leu Pro Glu Val Val Glu Leu 
            260                 265                 270         


Gly Ile Leu Asp Gln Leu Ser Thr Glu Glu Arg Lys Arg Gln Glu Ala 
        275                 280                 285             


Met Phe Glu Ile Leu Thr Ser Glu Phe Ser Tyr Gln His Ser Leu Ser 
    290                 295                 300                 


Ile Leu Val Glu Glu Phe Leu Gln Ser Lys Glu Leu Arg Ala Thr Val 
305                 310                 315                 320 


Thr Gln Met Glu His His His Leu Phe Ser Asn Ile Leu Asp Val Leu 
                325                 330                 335     


Gly Ala Ser Gln Arg Phe Phe Glu Asp Leu Glu Gln Arg His Lys Ala 
            340                 345                 350         


Gln Val Leu Val Glu Asp Ile Ser Asp Ile Leu Glu Glu His Ala Glu 
        355                 360                 365             


Lys His Phe His Pro Tyr Ile Ala Tyr Cys Ser Asn Glu Val Tyr Gln 
    370                 375                 380                 


Gln Arg Thr Leu Gln Lys Leu Ile Ser Ser Asn Ala Ala Phe Arg Glu 
385                 390                 395                 400 


Ala Leu Arg Glu Ile Glu Arg Arg Pro Ala Cys Gly Gly Leu Pro Met 
                405                 410                 415     


Leu Ser Phe Leu Ile Leu Pro Met Gln Arg Val Thr Arg Leu Pro Leu 
            420                 425                 430         


Leu Met Asp Thr Leu Cys Leu Lys Thr Gln Gly His Ser Glu Arg Tyr 
        435                 440                 445             


Lys Ala Ala Ser Arg Ala Leu Lys Ala Ile Ser Lys Leu Val Arg Gln 
    450                 455                 460                 


Cys Asn Glu Gly Ala His Arg Met Glu Arg Met Glu Gln Met Tyr Thr 
465                 470                 475                 480 


Leu His Thr Gln Leu Asp Phe Ser Lys Val Lys Ser Leu Pro Leu Ile 
                485                 490                 495     


Ser Ala Ser Arg Trp Leu Leu Lys Arg Gly Glu Leu Phe Leu Val Glu 
            500                 505                 510         


Glu Thr Gly Leu Phe Arg Lys Ile Ala Ser Arg Pro Thr Cys Tyr Leu 
        515                 520                 525             


Phe Leu Phe Asn Asp Val Leu Val Val Thr Lys Lys Lys Ser Glu Glu 
    530                 535                 540                 


Ser Tyr Met Val Gln Asp Tyr Ala Gln Met Asn His Ile Gln Val Glu 
545                 550                 555                 560 


Lys Ile Glu Pro Ser Glu Leu Pro Leu Pro Gly Gly Gly Asn Arg Ser 
                565                 570                 575     


Ser Ser Val Pro His Pro Phe Gln Val Thr Leu Leu Arg Asn Ser Glu 
            580                 585                 590         


Gly Arg Gln Glu Gln Leu Leu Leu Ser Ser Asp Ser Ala Ser Asp Arg 
        595                 600                 605             


Ala Arg Trp Ile Val Ala Leu Thr His Ser Glu Arg Gln Trp Gln Gly 
    610                 615                 620                 


Leu Ser Ser Lys Gly Asp Leu Pro Gln Val Glu Ile Thr Lys Ala Phe 
625                 630                 635                 640 


Phe Ala Lys Gln Ala Asp Glu Val Thr Leu Gln Gln Ala Asp Val Val 
                645                 650                 655     


Leu Val Leu Gln Gln Glu Asp Gly Trp Leu Tyr Gly Glu Arg Leu Arg 
            660                 665                 670         


Asp Gly Glu Thr Gly Trp Phe Pro Glu Asp Phe Ala Arg Phe Ile Thr 
        675                 680                 685             


Ser Arg Val Ala Val Glu Gly Asn Val Arg Arg Met Glu Arg Leu Arg 
    690                 695                 700                 


Val Glu Thr Asp Val 
705                 


<210>  37
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Thr Glu Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        195                 200                 205             


Ser Thr Lys Pro Asn Ser Ser Thr Pro Ala Ser Pro Pro Gly Thr Ala 
    210                 215                 220                 


Ser Gly Arg Asn Ser Gly Ala Trp Glu Thr Lys Ser Pro Pro Pro Ala 
225                 230                 235                 240 


Ala Pro Ser Pro Leu Pro Arg Ala Gly Lys Lys Pro Thr Thr Pro Leu 
                245                 250                 255     


Lys Thr Thr Pro Val Ala Ser Gln Gln Asn Ala Ser Ser Val Cys Glu 
            260                 265                 270         


Glu Lys Pro Ile Pro Ala Glu Arg His Arg Gly Ser Ser His Arg Gln 
        275                 280                 285             


Glu Ala Val Gln Ser Pro Val Phe Pro Pro Ala Gln Lys Gln Ile His 
    290                 295                 300                 


Gln Lys Pro Ile Pro Leu Pro Arg Phe Thr Glu Gly Gly Asn Pro Thr 
305                 310                 315                 320 


Val Asp Gly Pro Leu Pro Ser Phe Ser Ser Asn Ser Thr Ile Ser Glu 
                325                 330                 335     


Gln Glu Ala Gly Val Leu Cys Lys Pro Trp Tyr Ala Gly Ala Cys Asp 
            340                 345                 350         


Arg Lys Ser Ala Glu Glu Ala Leu His Arg Ser Asn Lys Asp Gly Ser 
        355                 360                 365             


Phe Leu Ile Arg Lys Ser Ser Gly His Asp Ser Lys Gln Pro Tyr Thr 
    370                 375                 380                 


Leu Val Val Phe Phe Asn Lys Arg Val Tyr Asn Ile Pro Val Arg Phe 
385                 390                 395                 400 


Ile Glu Ala Thr Lys Gln Tyr Ala Leu Gly Arg Lys Lys Asn Gly Glu 
                405                 410                 415     


Glu Tyr Phe Gly Ser Val Ala Glu Ile Ile Arg Asn His Gln His Ser 
            420                 425                 430         


Pro Leu Val Leu Ile Asp Ser Gln Asn Asn Thr Lys Asp Ser Thr Arg 
        435                 440                 445             


Leu Lys Tyr Ala Val Lys Val Ser 
    450                 455     


<210>  38
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Thr Glu Ser Ser Ser Pro Pro Pro Glu Lys Gly Arg Asn Ser Gly Ala 
        195                 200                 205             


Trp Glu Thr Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg 
    210                 215                 220                 


Ala Gly Lys Lys Pro Thr Thr Pro Leu Lys Thr Thr Pro Val Ala Ser 
225                 230                 235                 240 


Gln Gln Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu 
                245                 250                 255     


Arg His Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro Val 
            260                 265                 270         


Phe Pro Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro 
        275                 280                 285             


Arg Phe Thr Glu Gly Gly Asn Pro Thr Val Asp Gly Pro Leu Pro Ser 
    290                 295                 300                 


Phe Ser Ser Asn Ser Thr Ile Ser Glu Gln Glu Ala Gly Val Leu Cys 
305                 310                 315                 320 


Lys Pro Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala 
                325                 330                 335     


Leu His Arg Ser Asn Lys Asp Gly Ser Phe Leu Ile Arg Lys Ser Ser 
            340                 345                 350         


Gly His Asp Ser Lys Gln Pro Tyr Thr Leu Val Val Phe Phe Asn Lys 
        355                 360                 365             


Arg Val Tyr Asn Ile Pro Val Arg Phe Ile Glu Ala Thr Lys Gln Tyr 
    370                 375                 380                 


Ala Leu Gly Arg Lys Lys Asn Gly Glu Glu Tyr Phe Gly Ser Val Ala 
385                 390                 395                 400 


Glu Ile Ile Arg Asn His Gln His Ser Pro Leu Val Leu Ile Asp Ser 
                405                 410                 415     


Gln Asn Asn Thr Lys Asp Ser Thr Arg Leu Lys Tyr Ala Val Lys Val 
            420                 425                 430         


Ser 
    


<210>  39
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Thr Glu Ser Ser Ser Pro Pro Pro Glu Lys Ala Pro Met Val Asn Arg 
        195                 200                 205             


Ser Thr Lys Pro Asn Ser Ser Thr Pro Ala Ser Pro Pro Gly Thr Ala 
    210                 215                 220                 


Ser Gly Arg Asn Ser Gly Ala Trp Glu Thr Lys Ser Pro Pro Pro Ala 
225                 230                 235                 240 


Ala Pro Ser Pro Leu Pro Arg Ala Gly Lys Lys Pro Thr Thr Pro Leu 
                245                 250                 255     


Lys Thr Thr Pro Val Ala Ser Gln Gln Asn Ala Ser Ser Val Cys Glu 
            260                 265                 270         


Glu Lys Pro Ile Pro Ala Glu Arg His Arg Gly Ser Ser His Arg Gln 
        275                 280                 285             


Glu Ala Val Gln Ser Pro Val Phe Pro Pro Ala Gln Lys Gln Ile His 
    290                 295                 300                 


Gln Lys Pro Ile Pro Leu Pro Arg Phe Thr Glu Gly Gly Asn Pro Thr 
305                 310                 315                 320 


Val Asp Gly Pro Leu Pro Ser Phe Ser Ser Asn Ser Thr Ile Ser Glu 
                325                 330                 335     


Gln Glu Ala Gly Val Leu Cys Lys Pro Trp Tyr Ala Gly Ala Cys Asp 
            340                 345                 350         


Arg Lys Ser Ala Glu Glu Ala Leu His Arg Ser Asn Lys Tyr Phe Gly 
        355                 360                 365             


Ser Val Ala Glu Ile Ile Arg Asn His Gln His Ser Pro Leu Val Leu 
    370                 375                 380                 


Ile Asp Ser Gln Asn Asn Thr Lys Asp Ser Thr Arg Leu Lys Tyr Ala 
385                 390                 395                 400 


Val Lys Val Ser 
                


<210>  40
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Glu Tyr Ile Asp Asn Arg Ser Ser Gln Arg His 
        115                 120                 125             


Ser Pro Pro Phe Ser Lys Thr Leu Pro Ser Lys Pro Ser Trp Pro Ser 
    130                 135                 140                 


Glu Lys Ala Arg Leu Thr Ser Thr Leu Pro Ala Leu Thr Ala Leu Gln 
145                 150                 155                 160 


Lys Pro Gln Val Pro Pro Lys Pro Lys Gly Leu Leu Glu Asp Glu Ala 
                165                 170                 175     


Asp Tyr Val Val Pro Val Glu Asp Asn Asp Glu Asn Tyr Ile His Pro 
            180                 185                 190         


Thr Glu Ser Ser Ser Pro Pro Pro Glu Lys Gly Arg Asn Ser Gly Ala 
        195                 200                 205             


Trp Glu Thr Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg 
    210                 215                 220                 


Ala Gly Lys Lys Pro Thr Thr Pro Leu Lys Thr Thr Pro Val Ala Ser 
225                 230                 235                 240 


Gln Gln Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu 
                245                 250                 255     


Arg His Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro Val 
            260                 265                 270         


Phe Pro Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro 
        275                 280                 285             


Arg Phe Thr Glu Gly Gly Asn Pro Thr Val Asp Gly Pro Leu Pro Ser 
    290                 295                 300                 


Phe Ser Ser Asn Ser Thr Ile Ser Glu Gln Glu Ala Gly Val Leu Cys 
305                 310                 315                 320 


Lys Pro Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala 
                325                 330                 335     


Leu His Arg Ser Asn Lys Tyr Phe Gly Ser Val Ala Glu Ile Ile Arg 
            340                 345                 350         


Asn His Gln His Ser Pro Leu Val Leu Ile Asp Ser Gln Asn Asn Thr 
        355                 360                 365             


Lys Asp Ser Thr Arg Leu Lys Tyr Ala Val Lys Val Ser 
    370                 375                 380     


<210>  41
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Asp Lys Leu Asn Lys Ile Thr Val Pro Ala Ser Gln Lys Leu Arg 
1               5                   10                  15      


Gln Leu Gln Lys Met Val His Asp Ile Lys Asn Asn Glu Gly Gly Ile 
            20                  25                  30          


Met Asn Lys Ile Lys Lys Leu Lys Val Lys Ala Pro Pro Ser Val Pro 
        35                  40                  45              


Arg Arg Asp Tyr Ala Ser Glu Ser Pro Ala Asp Glu Glu Glu Gln Trp 
    50                  55                  60                  


Ser Asp Asp Phe Asp Ser Asp Tyr Glu Asn Pro Asp Glu His Ser Asp 
65                  70                  75                  80  


Ser Glu Met Tyr Val Met Pro Ala Glu Glu Asn Ala Asp Asp Ser Tyr 
                85                  90                  95      


Glu Pro Pro Pro Val Glu Gln Glu Thr Arg Pro Val His Pro Ala Leu 
            100                 105                 110         


Pro Phe Ala Arg Gly Thr Ala Ser Gly Arg Asn Ser Gly Ala Trp Glu 
        115                 120                 125             


Thr Lys Ser Pro Pro Pro Ala Ala Pro Ser Pro Leu Pro Arg Ala Gly 
    130                 135                 140                 


Lys Lys Pro Thr Thr Pro Leu Lys Thr Thr Pro Val Ala Ser Gln Gln 
145                 150                 155                 160 


Asn Ala Ser Ser Val Cys Glu Glu Lys Pro Ile Pro Ala Glu Arg His 
                165                 170                 175     


Arg Gly Ser Ser His Arg Gln Glu Ala Val Gln Ser Pro Val Phe Pro 
            180                 185                 190         


Pro Ala Gln Lys Gln Ile His Gln Lys Pro Ile Pro Leu Pro Arg Phe 
        195                 200                 205             


Thr Glu Gly Gly Asn Pro Thr Val Asp Gly Pro Leu Pro Ser Phe Ser 
    210                 215                 220                 


Ser Asn Ser Thr Ile Ser Glu Gln Glu Ala Gly Val Leu Cys Lys Pro 
225                 230                 235                 240 


Trp Tyr Ala Gly Ala Cys Asp Arg Lys Ser Ala Glu Glu Ala Leu His 
                245                 250                 255     


Arg Ser Asn Lys Tyr Phe Gly Ser Val Ala Glu Ile Ile Arg Asn His 
            260                 265                 270         


Gln His Ser Pro Leu Val Leu Ile Asp Ser Gln Asn Asn Thr Lys Asp 
        275                 280                 285             


Ser Thr Arg Leu Lys Tyr Ala Val Lys Val Ser 
    290                 295                 


<210>  42
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Arg Arg Pro Pro Ser Arg Gly Gly Arg Gly Ala Ala Arg Ala 
1               5                   10                  15      


Arg Glu Thr Arg Arg Gln Pro Arg His Arg Ser Gly Arg Arg Met Ala 
            20                  25                  30          


Glu Ala Ile Ser Cys Thr Leu Asn Cys Ser Cys Gln Ser Phe Lys Pro 
        35                  40                  45              


Gly Lys Ile Asn His Arg Gln Cys Asp Gln Cys Lys His Gly Trp Val 
    50                  55                  60                  


Ala His Ala Leu Ser Lys Leu Arg Ile Pro Pro Met Tyr Pro Thr Ser 
65                  70                  75                  80  


Gln Val Glu Ile Val Gln Ser Asn Val Val Phe Asp Ile Ser Ser Leu 
                85                  90                  95      


Met Leu Tyr Gly Thr Gln Ala Ile Pro Val Arg Leu Lys Ile Leu Leu 
            100                 105                 110         


Asp Arg Leu Phe Ser Val Leu Lys Gln Asp Glu Val Leu Gln Ile Leu 
        115                 120                 125             


His Ala Leu Asp Trp Thr Leu Gln Asp Tyr Ile Arg Gly Tyr Val Leu 
    130                 135                 140                 


Gln Asp Ala Ser Gly Lys Val Leu Asp His Trp Ser Ile Met Thr Ser 
145                 150                 155                 160 


Glu Glu Glu Val Ala Thr Leu Gln Gln Phe Leu Arg Phe Gly Glu Thr 
                165                 170                 175     


Lys Ser Ile Val Glu Leu Met Ala Ile Gln Glu Lys Glu Glu Gln Ser 
            180                 185                 190         


Ile Ile Ile Pro Pro Ser Thr Ala Asn Val Asp Ile Arg Ala Phe Ile 
        195                 200                 205             


Glu Ser Cys Ser His Arg Ser Ser Ser Leu Pro Thr Pro Val Asp Lys 
    210                 215                 220                 


Gly Asn Pro Ser Ser Ile His Pro Phe Glu Asn Leu Ile Ser Asn Met 
225                 230                 235                 240 


Thr Phe Met Leu Pro Phe Gln Phe Phe Asn Pro Leu Pro Pro Ala Leu 
                245                 250                 255     


Ile Gly Ser Leu Pro Glu Gln Tyr Met Leu Glu Gln Gly His Asp Gln 
            260                 265                 270         


Ser Gln Asp Pro Lys Gln Glu Val His Gly Pro Phe Pro Asp Ser Ser 
        275                 280                 285             


Phe Leu Thr Ser Ser Ser Thr Pro Phe Gln Val Glu Lys Asp Gln Cys 
    290                 295                 300                 


Leu Asn Cys Pro Asp Ala Ile Thr Lys Lys Glu Asp Ser Thr His Leu 
305                 310                 315                 320 


Ser Asp Ser Ser Ser Tyr Asn Ile Val Thr Lys Phe Glu Arg Thr Gln 
                325                 330                 335     


Leu Ser Pro Glu Ala Lys Val Lys Pro Glu Arg Asn Ser Leu Gly Thr 
            340                 345                 350         


Lys Lys Gly Arg Val Phe Cys Thr Ala Cys Glu Lys Thr Phe Tyr Asp 
        355                 360                 365             


Lys Gly Thr Leu Lys Ile His Tyr Asn Ala Val His Leu Lys Ile Lys 
    370                 375                 380                 


His Lys Cys Thr Ile Glu Gly Cys Asn Met Val Phe Ser Ser Leu Arg 
385                 390                 395                 400 


Ser Arg Asn Arg His Ser Ala Asn Pro Asn Pro Arg Leu His Met Pro 
                405                 410                 415     


Met Asn Arg Asn Asn Arg Asp Lys Asp Leu Arg Asn Ser Leu Asn Leu 
            420                 425                 430         


Ala Ser Ser Glu Asn Tyr Lys Cys Pro Gly Phe Thr Val Thr Ser Pro 
        435                 440                 445             


Asp Cys Arg Pro Pro Pro Ser Tyr Pro Gly Ser Gly Glu Asp Ser Lys 
    450                 455                 460                 


Gly Gln Pro Ala Phe Pro Asn Ile Gly Gln Asn Gly Val Leu Phe Pro 
465                 470                 475                 480 


Asn Leu Lys Thr Val Gln Pro Val Leu Pro Phe Tyr Arg Ser Pro Ala 
                485                 490                 495     


Thr Pro Ala Glu Val Ala Asn Thr Pro Gly Ile Leu Pro Ser Leu Pro 
            500                 505                 510         


Leu Leu Ser Ser Ser Ile Pro Glu Gln Leu Ile Ser Asn Glu Met Pro 
        515                 520                 525             


Phe Asp Ala Leu Pro Lys Lys Lys Ser Arg Lys Ser Ser Met Pro Ile 
    530                 535                 540                 


Lys Ile Glu Lys Glu Ala Val Glu Ile Ala Asn Glu Lys Arg His Asn 
545                 550                 555                 560 


Leu Ser Ser Asp Glu Asp Met Pro Leu Gln Val Val Ser Glu Asp Glu 
                565                 570                 575     


Gln Glu Ala Cys Ser Pro Gln Ser His Arg Val Ser Glu Glu Gln His 
            580                 585                 590         


Val Gln Ser Gly Gly Leu Gly Lys Pro Phe Pro Glu Gly Glu Arg Pro 
        595                 600                 605             


Cys His Arg Glu Ser Val Ile Glu Ser Ser Gly Ala Ile Ser Gln Thr 
    610                 615                 620                 


Pro Glu Gln Ala Thr His Asn Ser Glu Arg Glu Thr Glu Gln Thr Pro 
625                 630                 635                 640 


Ala Leu Ile Met Val Pro Arg Glu Val Glu Asp Gly Gly His Glu His 
                645                 650                 655     


Tyr Phe Thr Pro Gly Met Glu Pro Gln Val Pro Phe Ser Asp Tyr Met 
            660                 665                 670         


Glu Leu Gln Gln Arg Leu Leu Ala Gly Gly Leu Phe Ser Ala Leu Ser 
        675                 680                 685             


Asn Arg Gly Met Ala Phe Pro Cys Leu Glu Asp Ser Lys Glu Leu Glu 
    690                 695                 700                 


His Val Gly Gln His Ala Leu Ala Arg Gln Ile Glu Glu Asn Arg Phe 
705                 710                 715                 720 


Gln Cys Asp Ile Cys Lys Lys Thr Phe Lys Asn Ala Cys Ser Val Lys 
                725                 730                 735     


Ile His His Lys Asn Met His Val Lys Glu Met His Thr Cys Thr Val 
            740                 745                 750         


Glu Gly Cys Asn Ala Thr Phe Pro Ser Arg Arg Ser Arg Asp Arg His 
        755                 760                 765             


Ser Ser Asn Leu Asn Leu His Gln Lys Ala Leu Ser Gln Glu Ala Leu 
    770                 775                 780                 


Glu Ser Ser Glu Asp His Phe Arg Ala Ala Tyr Leu Leu Lys Asp Val 
785                 790                 795                 800 


Ala Lys Glu Ala Tyr Gln Asp Val Ala Phe Thr Gln Gln Ala Ser Gln 
                805                 810                 815     


Thr Ser Val Ile Phe Lys Gly Thr Ser Arg Met Gly Ser Leu Val Tyr 
            820                 825                 830         


Pro Ile Thr Gln Val His Ser Ala Ser Leu Glu Ser Tyr Asn Ser Gly 
        835                 840                 845             


Pro Leu Ser Glu Gly Thr Ile Leu Asp Leu Ser Thr Thr Ser Ser Met 
    850                 855                 860                 


Lys Ser Glu Ser Ser Ser His Ser Ser Trp Asp Ser Asp Gly Val Ser 
865                 870                 875                 880 


Glu Glu Gly Thr Val Leu Met Glu Asp Ser Asp Gly Asn Cys Glu Gly 
                885                 890                 895     


Ser Ser Leu Val Pro Gly Glu Asp Glu Tyr Pro Ile Cys Val Leu Met 
            900                 905                 910         


Glu Lys Ala Asp Gln Ser Leu Ala Ser Leu Pro Ser Gly Leu Pro Ile 
        915                 920                 925             


Thr Cys His Leu Cys Gln Lys Thr Tyr Ser Asn Lys Gly Thr Phe Arg 
    930                 935                 940                 


Ala His Tyr Lys Thr Val His Leu Arg Gln Leu His Lys Cys Lys Val 
945                 950                 955                 960 


Pro Gly Cys Asn Thr Met Phe Ser Ser Val Arg Ser Arg Asn Arg His 
                965                 970                 975     


Ser Gln Asn Pro Asn Leu His Lys Ser Leu Ala Ser Ser Pro Ser His 
            980                 985                 990         


Leu Gln 
        


<210>  43
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Arg Cys Arg Asn Met Phe Phe Ser Phe Lys Ala Ser Leu Cys Gly 
1               5                   10                  15      


Cys Gly Ala Ala Thr Ala Pro Ser Leu Thr Ala Ile Ser Cys Thr Leu 
            20                  25                  30          


Asn Cys Ser Cys Gln Ser Phe Lys Pro Gly Lys Ile Asn His Arg Gln 
        35                  40                  45              


Cys Asp Gln Cys Lys His Gly Trp Val Ala His Ala Leu Ser Lys Leu 
    50                  55                  60                  


Arg Ile Pro Pro Met Tyr Pro Thr Ser Gln Val Glu Ile Val Gln Ser 
65                  70                  75                  80  


Asn Val Val Phe Asp Ile Ser Ser Leu Met Leu Tyr Gly Thr Gln Ala 
                85                  90                  95      


Ile Pro Val Arg Leu Lys Ile Leu Leu Asp Arg Leu Phe Ser Val Leu 
            100                 105                 110         


Lys Gln Asp Glu Val Leu Gln Ile Leu His Ala Leu Asp Trp Thr Leu 
        115                 120                 125             


Gln Asp Tyr Ile Arg Gly Tyr Val Leu Gln Asp Ala Ser Gly Lys Val 
    130                 135                 140                 


Leu Asp His Trp Ser Ile Met Thr Ser Glu Glu Glu Val Ala Thr Leu 
145                 150                 155                 160 


Gln Gln Phe Leu Arg Phe Gly Glu Thr Lys Ser Ile Val Glu Leu Met 
                165                 170                 175     


Ala Ile Gln Glu Lys Glu Glu Gln Ser Ile Ile Ile Pro Pro Ser Thr 
            180                 185                 190         


Ala Asn Val Asp Ile Arg Ala Phe Ile Glu Ser Cys Ser His Arg Ser 
        195                 200                 205             


Ser Ser Leu Pro Thr Pro Val Asp Lys Gly Asn Pro Ser Ser Ile His 
    210                 215                 220                 


Pro Phe Glu Asn Leu Ile Ser Asn Met Thr Phe Met Leu Pro Phe Gln 
225                 230                 235                 240 


Phe Phe Asn Pro Leu Pro Pro Ala Leu Ile Gly Ser Leu Pro Glu Gln 
                245                 250                 255     


Tyr Met Leu Glu Gln Gly His Asp Gln Ser Gln Asp Pro Lys Gln Glu 
            260                 265                 270         


Val His Gly Pro Phe Pro Asp Ser Ser Phe Leu Thr Ser Ser Ser Thr 
        275                 280                 285             


Pro Phe Gln Val Glu Lys Asp Gln Cys Leu Asn Cys Pro Asp Ala Ile 
    290                 295                 300                 


Thr Lys Lys Glu Asp Ser Thr His Leu Ser Asp Ser Ser Ser Tyr Asn 
305                 310                 315                 320 


Ile Val Thr Lys Phe Glu Arg Thr Gln Leu Ser Pro Glu Ala Lys Val 
                325                 330                 335     


Lys Pro Glu Arg Asn Ser Leu Gly Thr Lys Lys Gly Arg Val Phe Cys 
            340                 345                 350         


Thr Ala Cys Glu Lys Thr Phe Tyr Asp Lys Gly Thr Leu Lys Ile His 
        355                 360                 365             


Tyr Asn Ala Val His Leu Lys Ile Lys His Lys Cys Thr Ile Glu Gly 
    370                 375                 380                 


Cys Asn Met Val Phe Ser Ser Leu Arg Ser Arg Asn Arg His Ser Ala 
385                 390                 395                 400 


Asn Pro Asn Pro Arg Leu His Met Pro Met Asn Arg Asn Asn Arg Asp 
                405                 410                 415     


Lys Asp Leu Arg Asn Ser Leu Asn Leu Ala Ser Ser Glu Asn Tyr Lys 
            420                 425                 430         


Cys Pro Gly Phe Thr Val Thr Ser Pro Asp Cys Arg Pro Pro Pro Ser 
        435                 440                 445             


Tyr Pro Gly Ser Gly Glu Asp Ser Lys Gly Gln Pro Ala Phe Pro Asn 
    450                 455                 460                 


Ile Gly Gln Asn Gly Val Leu Phe Pro Asn Leu Lys Thr Val Gln Pro 
465                 470                 475                 480 


Val Leu Pro Phe Tyr Arg Ser Pro Ala Thr Pro Ala Glu Val Ala Asn 
                485                 490                 495     


Thr Pro Gly Ile Leu Pro Ser Leu Pro Leu Leu Ser Ser Ser Ile Pro 
            500                 505                 510         


Glu Gln Leu Ile Ser Asn Glu Met Pro Phe Asp Ala Leu Pro Lys Lys 
        515                 520                 525             


Lys Ser Arg Lys Ser Ser Met Pro Ile Lys Ile Glu Lys Glu Ala Val 
    530                 535                 540                 


Glu Ile Ala Asn Glu Lys Arg His Asn Leu Ser Ser Asp Glu Asp Met 
545                 550                 555                 560 


Pro Leu Gln Val Val Ser Glu Asp Glu Gln Glu Ala Cys Ser Pro Gln 
                565                 570                 575     


Ser His Arg Val Ser Glu Glu Gln His Val Gln Ser Gly Gly Leu Gly 
            580                 585                 590         


Lys Pro Phe Pro Glu Gly Glu Arg Pro Cys His Arg Glu Ser Val Ile 
        595                 600                 605             


Glu Ser Ser Gly Ala Ile Ser Gln Thr Pro Glu Gln Ala Thr His Asn 
    610                 615                 620                 


Ser Glu Arg Glu Thr Glu Gln Thr Pro Ala Leu Ile Met Val Pro Arg 
625                 630                 635                 640 


Glu Val Glu Asp Gly Gly His Glu His Tyr Phe Thr Pro Gly Met Glu 
                645                 650                 655     


Pro Gln Val Pro Phe Ser Asp Tyr Met Glu Leu Gln Gln Arg Leu Leu 
            660                 665                 670         


Ala Gly Gly Leu Phe Ser Ala Leu Ser Asn Arg Gly Met Ala Phe Pro 
        675                 680                 685             


Cys Leu Glu Asp Ser Lys Glu Leu Glu His Val Gly Gln His Ala Leu 
    690                 695                 700                 


Ala Arg Gln Ile Glu Glu Asn Arg Phe Gln Cys Asp Ile Cys Lys Lys 
705                 710                 715                 720 


Thr Phe Lys Asn Ala Cys Ser Val Lys Ile His His Lys Asn Met His 
                725                 730                 735     


Val Lys Glu Met His Thr Cys Thr Val Glu Gly Cys Asn Ala Thr Phe 
            740                 745                 750         


Pro Ser Arg Arg Ser Arg Asp Arg His Ser Ser Asn Leu Asn Leu His 
        755                 760                 765             


Gln Lys Ala Leu Ser Gln Glu Ala Leu Glu Ser Ser Glu Asp His Phe 
    770                 775                 780                 


Arg Ala Ala Tyr Leu Leu Lys Asp Val Ala Lys Glu Ala Tyr Gln Asp 
785                 790                 795                 800 


Val Ala Phe Thr Gln Gln Ala Ser Gln Thr Ser Val Ile Phe Lys Gly 
                805                 810                 815     


Thr Ser Arg Met Gly Ser Leu Val Tyr Pro Ile Thr Gln Val His Ser 
            820                 825                 830         


Ala Ser Leu Glu Ser Tyr Asn Ser Gly Pro Leu Ser Glu Gly Thr Ile 
        835                 840                 845             


Leu Asp Leu Ser Thr Thr Ser Ser Met Lys Ser Glu Ser Ser Ser His 
    850                 855                 860                 


Ser Ser Trp Asp Ser Asp Gly Val Ser Glu Glu Gly Thr Val Leu Met 
865                 870                 875                 880 


Glu Asp Ser Asp Gly Asn Cys Glu Gly Ser Ser Leu Val Pro Gly Glu 
                885                 890                 895     


Asp Glu Tyr Pro Ile Cys Val Leu Met Glu Lys Ala Asp Gln Ser Leu 
            900                 905                 910         


Ala Ser Leu Pro Ser Gly Leu Pro Ile Thr Cys His Leu Cys Gln Lys 
        915                 920                 925             


Thr Tyr Ser Asn Lys Gly Thr Phe Arg Ala His Tyr Lys Thr Val His 
    930                 935                 940                 


Leu Arg Gln Leu His Lys Cys Lys Val Pro Gly Cys Asn Thr Met Phe 
945                 950                 955                 960 


Ser Ser Val Arg Ser Arg Asn Arg His Ser Gln Asn Pro Asn Leu His 
                965                 970                 975     


Lys Ser Leu Ala Ser Ser Pro Ser His Leu Gln 
            980                 985         


<210>  44
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Phe Gln Thr Gly Gly Leu Ile Val Phe Tyr Gly Leu Leu Ala Gln 
1               5                   10                  15      


Thr Met Ala Gln Phe Gly Gly Leu Pro Val Pro Leu Asp Gln Thr Leu 
            20                  25                  30          


Pro Leu Asn Val Asn Pro Ala Leu Pro Leu Ser Pro Thr Gly Leu Ala 
        35                  40                  45              


Gly Ser Leu Thr Asn Ala Leu Ser Asn Gly Leu Leu Ser Gly Gly Leu 
    50                  55                  60                  


Leu Gly Ile Leu Glu Asn Leu Pro Leu Leu Asp Ile Leu Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Thr Ser Gly Gly Leu Leu Gly Gly Leu Leu Gly Lys Val Thr 
                85                  90                  95      


Ser Val Ile Pro Gly Leu Asn Asn Ile Ile Asp Ile Lys Val Thr Asp 
            100                 105                 110         


Pro Gln Leu Leu Glu Leu Gly Leu Val Gln Ser Pro Asp Gly His Arg 
        115                 120                 125             


Leu Tyr Val Thr Ile Pro Leu Gly Ile Lys Leu Gln Val Asn Thr Pro 
    130                 135                 140                 


Leu Val Gly Ala Ser Leu Leu Arg Leu Ala Val Lys Leu Asp Ile Thr 
145                 150                 155                 160 


Ala Glu Ile Leu Ala Val Arg Asp Lys Gln Glu Arg Ile His Leu Val 
                165                 170                 175     


Leu Gly Asp Cys Thr His Ser Pro Gly Ser Leu Gln Ile Ser Leu Leu 
            180                 185                 190         


Asp Gly Leu Gly Pro Leu Pro Ile Gln Gly Leu Leu Asp Ser Leu Thr 
        195                 200                 205             


Gly Ile Leu Asn Lys Val Leu Pro Glu Leu Val Gln Gly Asn Val Cys 
    210                 215                 220                 


Pro Leu Val Asn Glu Val Leu Arg Gly Leu Asp Ile Thr Leu Val His 
225                 230                 235                 240 


Asp Ile Val Asn Met Leu Ile His Gly Leu Gln Phe Val Ile Lys Val 
                245                 250                 255     


<210>  45
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
65                  70                  75                  80  


Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                85                  90                  95      


Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
        115                 120                 125             


Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
    130                 135                 140                 


Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
145                 150                 155                 160 


Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser 
                165                 170                 175     


Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
            180                 185                 190         


Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
        195                 200                 205             


Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala 
    210                 215                 220                 


Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg 
225                 230                 235                 240 


Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
                245                 250                 255     


Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
            260                 265                 270         


Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile 
        275                 280                 285             


Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile 
    290                 295                 300                 


Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met 
305                 310                 315                 320 


Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile 
                325                 330                 335     


Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr 
            340                 345                 350         


Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly 
        355                 360                 365             


Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu 
    370                 375                 380                 


Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu 
385                 390                 395                 400 


Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Thr Gly 
                405                 410                 415     


Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala 
            420                 425                 430         


Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser Gly Leu Pro 
        435                 440                 445             


Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser 
    450                 455                 460                 


Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro 
465                 470                 475                 480 


Lys Asp Ser Tyr 
                


<210>  46
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys Lys Tyr Ser Asn Asp Trp Trp Ile 
    50                  55                  60                  


Gly Arg Leu Val Lys Glu Gly Gly Asp Ile Ala Phe Ile Pro Ser Pro 
65                  70                  75                  80  


Gln Arg Leu Glu Ser Ile Arg Leu Lys Gln Glu Gln Lys Ala Arg Arg 
                85                  90                  95      


Ser Gly Asn Pro Ser Ser Leu Ser Asp Ile Gly Asn Arg Arg Ser Pro 
            100                 105                 110         


Pro Pro Ser Leu Ala Lys Gln Lys Gln Lys Gln Ala Glu His Val Pro 
        115                 120                 125             


Pro Tyr Asp Val Val Pro Ser Met Arg Pro Val Val Leu Val Gly Pro 
    130                 135                 140                 


Ser Leu Lys Gly Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe 
145                 150                 155                 160 


Asp Phe Leu Lys His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val 
                165                 170                 175     


Thr Ala Asp Leu Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Gly 
            180                 185                 190         


Lys Arg Thr Ile Ile Glu Arg Ser Ser Ala Arg Ser Ser Ile Ala Glu 
        195                 200                 205             


Val Gln Ser Glu Ile Glu Arg Ile Phe Glu Leu Ala Lys Ser Leu Gln 
    210                 215                 220                 


Leu Val Val Leu Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ala 
225                 230                 235                 240 


Lys Thr Ser Leu Ala Pro Ile Ile Val Phe Val Lys Val Ser Ser Pro 
                245                 250                 255     


Lys Val Leu Gln Arg Leu Ile Arg Ser Arg Gly Lys Ser Gln Met Lys 
            260                 265                 270         


His Leu Thr Val Gln Met Met Ala Tyr Asp Lys Leu Val Gln Cys Pro 
        275                 280                 285             


Pro Glu Ser Phe Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala 
    290                 295                 300                 


Cys Glu His Leu Ala Glu Tyr Leu Glu Val Tyr Trp Arg Ala Thr His 
305                 310                 315                 320 


His Pro Ala Pro Gly Pro Gly Leu Leu Gly Pro Pro Ser Ala Ile Pro 
                325                 330                 335     


Gly Leu Gln Asn Gln Gln Leu Leu Gly Glu Arg Gly Glu Glu His Ser 
            340                 345                 350         


Pro Leu Glu Arg Asp Ser Leu Met Pro Ser Asp Glu Ala Ser Glu Ser 
        355                 360                 365             


Ser Arg Gln Ala Trp Thr Gly Ser Ser Gln Arg Ser Ser Arg His Leu 
    370                 375                 380                 


Glu Glu Asp Tyr Ala Asp Ala Tyr Gln Asp Leu Tyr Gln Pro His Arg 
385                 390                 395                 400 


Gln His Thr Ser Gly Leu Pro Ser Ala Asn Gly His Asp Pro Gln Asp 
                405                 410                 415     


Arg Leu Leu Ala Gln Asp Ser Glu His Asn His Ser Asp Arg Asn Trp 
            420                 425                 430         


Gln Arg Asn Arg Pro Trp Pro Lys Asp Ser Tyr 
        435                 440             


<210>  47
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Phe Ser Asp Ser Ser Ala Thr Phe Leu Leu Asn Glu Gly Ser 
1               5                   10                  15      


Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser Leu 
            20                  25                  30          


Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala Gln 
        35                  40                  45              


Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val Arg 
    50                  55                  60                  


Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val Gln 
65                  70                  75                  80  


Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys Glu 
                85                  90                  95      


Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly Gly 
            100                 105                 110         


Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg Leu 
        115                 120                 125             


Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu Ser 
    130                 135                 140                 


Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln Lys 
145                 150                 155                 160 


Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser Met 
                165                 170                 175     


Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val Thr 
            180                 185                 190         


Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe Asp 
        195                 200                 205             


Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala Lys 
    210                 215                 220                 


Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg Ser 
225                 230                 235                 240 


Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg Ile 
                245                 250                 255     


Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp Thr 
            260                 265                 270         


Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile Ile 
        275                 280                 285             


Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile Arg 
    290                 295                 300                 


Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met Ala 
305                 310                 315                 320 


Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile Leu 
                325                 330                 335     


Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr Leu 
            340                 345                 350         


Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly Leu 
        355                 360                 365             


Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu Leu 
    370                 375                 380                 


Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu Met 
385                 390                 395                 400 


Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Thr Gly Ser 
                405                 410                 415     


Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala Tyr 
            420                 425                 430         


Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser Gly Leu Pro Ser 
        435                 440                 445             


Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser Glu 
    450                 455                 460                 


His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro Lys 
465                 470                 475                 480 


Asp Ser Tyr 
            


<210>  48
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser 
1               5                   10                  15      


Asp Val Ser Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu 
            20                  25                  30          


Ser Gln Ala Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala 
        35                  40                  45              


Phe Ala Val Arg Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu 
    50                  55                  60                  


Cys Pro Val Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu 
65                  70                  75                  80  


His Ile Lys Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val 
                85                  90                  95      


Lys Glu Gly Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu 
            100                 105                 110         


Ser Ile Arg Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro 
        115                 120                 125             


Ser Ser Leu Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu 
    130                 135                 140                 


Ala Lys Gln Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val 
145                 150                 155                 160 


Val Pro Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly 
                165                 170                 175     


Tyr Glu Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys 
            180                 185                 190         


His Arg Phe Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu 
        195                 200                 205             


Ser Leu Ala Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile 
    210                 215                 220                 


Ile Glu Arg Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu 
225                 230                 235                 240 


Ile Glu Arg Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu 
                245                 250                 255     


Asp Ala Asp Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu 
            260                 265                 270         


Ala Pro Ile Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln 
        275                 280                 285             


Arg Leu Ile Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val 
    290                 295                 300                 


Gln Met Met Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe 
305                 310                 315                 320 


Asp Val Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu 
                325                 330                 335     


Ala Glu Tyr Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro 
            340                 345                 350         


Gly Pro Gly Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn 
        355                 360                 365             


Gln Gln Leu Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg 
    370                 375                 380                 


Asp Ser Leu Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala 
385                 390                 395                 400 


Trp Thr Gly Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr 
                405                 410                 415     


Ala Asp Ala Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser 
            420                 425                 430         


Gly Leu Pro Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala 
        435                 440                 445             


Gln Asp Ser Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg 
    450                 455                 460                 


Pro Trp Pro Lys Asp Ser Tyr 
465                 470     


<210>  49
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  50
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Ser Gly Ile Ser Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro 
1               5                   10                  15      


Glu Met Gly Leu Cys Ile Ile Ile Asn Asn Lys Asn Phe His Lys Ser 
            20                  25                  30          


Thr Gly Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu 
        35                  40                  45              


Arg Glu Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp 
    50                  55                  60                  


Leu Thr Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu 
65                  70                  75                  80  


Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly 
                85                  90                  95      


Glu Glu Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys 
            100                 105                 110         


Ile Thr Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys 
        115                 120                 125             


Pro Lys Leu Phe Ile Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys 
    130                 135                 140                 


Gly Ile Glu Thr Asp Ser Gly Val Asp Asp Asp Met Ala Cys His Lys 
145                 150                 155                 160 


Ile Pro Val Glu Ala Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly 
                165                 170                 175     


Tyr Tyr Ser Trp Arg Asn Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser 
            180                 185                 190         


Leu Cys Ala Met Leu Lys Gln Tyr Ala Asp Lys Leu Glu Phe Met His 
        195                 200                 205             


Ile Leu Thr Arg Val Asn Arg Lys Val Ala Thr Glu Phe Glu Ser Phe 
    210                 215                 220                 


Ser Phe Asp Ala Thr Phe His Ala Lys Lys Gln Ile Pro Cys Ile Val 
225                 230                 235                 240 


Ser Met Leu Thr Lys Glu Leu Tyr Phe Tyr His 
                245                 250     


<210>  51
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Val Ile Ile Leu Gly Glu Ile Gln Arg Met Ala Pro Gly Ser Ser 
                165                 170                 175     


Ser Arg Phe Val Pro Cys 
            180         


<210>  52
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Asp Ala Leu Ile Lys Val Ser Met Glu Asn Thr Glu Asn Ser 
1               5                   10                  15      


Val Asp Ser Lys Ser Ile Lys Asn Leu Glu Pro Lys Ile Ile His Gly 
            20                  25                  30          


Ser Glu Ser Met Asp Ser Gly Ile Ser Leu Asp Asn Ser Tyr Lys Met 
        35                  40                  45              


Asp Tyr Pro Glu Met Gly Leu Cys Ile Ile Ile Asn Asn Lys Asn Phe 
    50                  55                  60                  


His Lys Ser Thr Gly Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala 
65                  70                  75                  80  


Ala Asn Leu Arg Glu Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn 
                85                  90                  95      


Lys Asn Asp Leu Thr Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val 
            100                 105                 110         


Ser Lys Glu Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu 
        115                 120                 125             


Ser His Gly Glu Glu Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp 
    130                 135                 140                 


Leu Lys Lys Ile Thr Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu 
145                 150                 155                 160 


Thr Gly Lys Pro Lys Leu Phe Ile Ile Gln Val Ile Ile Leu Gly Glu 
                165                 170                 175     


Ile Gln Arg Met Ala Pro Gly Ser Ser Ser Arg Phe Val Pro Cys 
            180                 185                 190     


<210>  53
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asp Ser Gly Ile Ser Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro 
1               5                   10                  15      


Glu Met Gly Leu Cys Ile Ile Ile Asn Asn Lys Asn Phe His Lys Ser 
            20                  25                  30          


Thr Gly Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu 
        35                  40                  45              


Arg Glu Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp 
    50                  55                  60                  


Leu Thr Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu 
65                  70                  75                  80  


Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly 
                85                  90                  95      


Glu Glu Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys 
            100                 105                 110         


Ile Thr Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys 
        115                 120                 125             


Pro Lys Leu Phe Ile Ile Gln Val Ile Ile Leu Gly Glu Ile Gln Arg 
    130                 135                 140                 


Met Ala Pro Gly Ser Ser Ser Arg Phe Val Pro Cys 
145                 150                 155     


<210>  54
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  55
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys 
1               5                   10                  15      


Glu Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val 
            20                  25                  30          


Val Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His 
        35                  40                  45              


Ser Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr 
    50                  55                  60                  


Lys Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met 
65                  70                  75                  80  


Ala Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile 
                85                  90                  95      


Trp Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys 
            100                 105                 110         


Ile Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu 
        115                 120                 125             


Phe Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln 
    130                 135                 140                 


Lys Glu Ile 
145         


<210>  56
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  57
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Gly Leu Asp Phe Glu 
    370                 375                 380                 


Ala Lys Gln Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro 
385                 390                 395                 400 


Phe Glu Val Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val 
                405                 410                 415     


Leu Asp Val Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val 
            420                 425                 430         


Glu Val Ser Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr 
        435                 440                 445             


Ala Gln Glu Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile 
    450                 455                 460                 


Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala 
465                 470                 475                 480 


Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys 
                485                 490                 495     


Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro 
            500                 505                 510         


Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn 
        515                 520                 525             


Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg 
    530                 535                 540                 


Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro 
545                 550                 555                 560 


Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn 
                565                 570                 575     


Trp Thr Ile Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys 
            580                 585                 590         


Pro Lys Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu 
        595                 600                 605             


Met Asp Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val 
    610                 615                 620                 


Cys Asp Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val 
625                 630                 635                 640 


Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile 
                645                 650                 655     


Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg 
            660                 665                 670         


Arg Ala Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg 
        675                 680                 685             


Asp Asn Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln 
    690                 695                 700                 


Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu 
705                 710                 715                 720 


Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr 
                725                 730                 735     


Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu 
            740                 745                 750         


Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
        755                 760                 765             


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu 
    770                 775                 780                 


Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr 
785                 790                 795                 800 


Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly 
                805                 810                 815     


Gly Gly Glu Asp Asp 
            820     


<210>  58
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp 
1               5                   10                  15      


Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu 
            20                  25                  30          


Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu 
        35                  40                  45              


Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr Gly Thr Gly Thr 
    50                  55                  60                  


Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala Pro Ile Pro Glu 
65                  70                  75                  80  


Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys Pro Gln Val Ile 
                85                  90                  95      


Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser Pro Phe Thr Ala 
            100                 105                 110         


Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile Gln Tyr Asn Asp 
        115                 120                 125             


Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val 
    130                 135                 140                 


Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp 
145                 150                 155                 160 


Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala 
                165                 170                 175     


Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro 
            180                 185                 190         


Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu Leu Ile Leu Ile 
        195                 200                 205             


Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val Val Lys Glu Pro 
    210                 215                 220                 


Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val Tyr Tyr Tyr Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp Leu Ser Gln Leu 
                245                 250                 255     


His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg Asn Asp Val Ala 
            260                 265                 270         


Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg Pro Ala Asn Pro 
        275                 280                 285             


Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala Asp Thr 
    290                 295                 300                 


Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu 
305                 310                 315                 320 


Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu Asn Ser Ser Glu 
                325                 330                 335     


Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Asn Arg 
            340                 345                 350         


Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
        355                 360                 365     


<210>  59
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp 
1               5                   10                  15      


Asn Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp 
            20                  25                  30          


Cys Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala 
        35                  40                  45              


Gly Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala 
    50                  55                  60                  


Leu Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala 
65                  70                  75                  80  


Val Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn 
                85                  90                  95      


Val Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe 
            100                 105                 110         


Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr 
        115                 120                 125             


Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro 
    130                 135                 140                 


Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu 
145                 150                 155                 160 


Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu 
                165                 170                 175     


Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser 
            180                 185                 190         


Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn 
        195                 200                 205             


Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly 
    210                 215                 220                 


Glu Asp Asp 
225         


<210>  60
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Pro Leu Leu Arg Gly Arg Cys Pro Ala Arg Arg His Tyr Arg Arg 
1               5                   10                  15      


Leu Ala Leu Leu Gly Leu Gln Pro Ala Pro Arg Phe Ala His Ser Gly 
            20                  25                  30          


Pro Pro Arg Gln Arg Pro Leu Ser Ala Ala Glu Met Ala Val Gly Leu 
        35                  40                  45              


Val Val Phe Phe Thr Thr Phe Leu Thr Pro Ala Ala Tyr Val Leu Gly 
    50                  55                  60                  


Asn Leu Lys Gln Phe Arg Arg Asn 
65                  70          


<210>  61
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
1               5                   10                  15      


Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
        35                  40                  45              


Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
    50                  55                  60                  


Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
                85                  90                  95      


Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
            100                 105                 110         


Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
    130                 135                 140                 


Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
145                 150                 155                 160 


Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                165                 170                 175     


Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
            180                 185                 190         


Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
        195                 200                 205             


Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
225                 230                 235                 240 


Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                245                 250                 255     


Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
            260                 265                 270         


Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
        275                 280                 285             


Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
    290                 295                 300                 


Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
305                 310                 315                 320 


Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
                325                 330                 335     


Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
            340                 345                 350         


Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
        355                 360                 365             


Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
    370                 375                 380                 


Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
385                 390                 395                 400 


Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                405                 410                 415     


Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
            420                 425                 430         


Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
        435                 440                 445             


Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
465                 470                 475                 480 


Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
                485                 490                 495     


Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
            500                 505                 510         


Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
        515                 520                 525             


Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
    530                 535                 540                 


Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
545                 550                 555                 560 


Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Leu Ala Leu Gln Leu 
                565                 570                 575     


Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
            580                 585                 590         


Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
        595                 600                 605             


Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
    610                 615                 620                 


Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
625                 630                 635                 640 


Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
                645                 650                 655     


Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
            660                 665                 670         


Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
        675                 680                 685             


Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
    690                 695                 700                 


Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
705                 710                 715                 720 


Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
                725                 730                 735     


Ser Ser Lys Phe Ser Cys Pro Glu Thr Asp Ser His Arg Phe Gly Arg 
            740                 745                 750         


His Leu Lys Glu Ala Met Thr Asp Ile Ile Thr Leu Phe Gly Leu Ser 
        755                 760                 765             


Ser Asn Ser Lys Lys 
    770             


<210>  62
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro 
1               5                   10                  15      


Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr 
            20                  25                  30          


Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn 
        35                  40                  45              


Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile 
    50                  55                  60                  


Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser 
65                  70                  75                  80  


Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys 
                85                  90                  95      


Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr 
            100                 105                 110         


Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val 
        115                 120                 125             


Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser 
    130                 135                 140                 


Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg 
145                 150                 155                 160 


Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val 
                165                 170                 175     


Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro 
            180                 185                 190         


Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp 
        195                 200                 205             


Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys 
    210                 215                 220                 


Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile 
225                 230                 235                 240 


Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala 
                245                 250                 255     


Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala 
            260                 265                 270         


Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg 
        275                 280                 285             


Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys 
    290                 295                 300                 


Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu 
305                 310                 315                 320 


Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val 
                325                 330                 335     


Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg 
            340                 345                 350         


Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp 
        355                 360                 365             


Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr 
    370                 375                 380                 


Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly 
385                 390                 395                 400 


Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe 
                405                 410                 415     


Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro 
            420                 425                 430         


Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys 
        435                 440                 445             


Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Pro Ile 
465                 470                 475                 480 


Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu 
                485                 490                 495     


Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile 
            500                 505                 510         


Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu 
        515                 520                 525             


Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val 
    530                 535                 540                 


Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys 
545                 550                 555                 560 


Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Leu Ala Leu Gln Leu 
                565                 570                 575     


Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser 
            580                 585                 590         


Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys 
        595                 600                 605             


Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln 
    610                 615                 620                 


Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His 
625                 630                 635                 640 


Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His 
                645                 650                 655     


Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro 
            660                 665                 670         


Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln 
        675                 680                 685             


Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu 
    690                 695                 700                 


Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr 
705                 710                 715                 720 


Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile 
                725                 730                 735     


Ser Ser Lys Phe Ser Cys Pro Glu Thr Gly Ile Ile Ser Gln Gly Pro 
            740                 745                 750         


Ser Ser Asp Thr 
        755     


<210>  63
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  64
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  65
<211>  1164
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala 
            20                  25                  30          


Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro 
        35                  40                  45              


Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys 
    50                  55                  60                  


Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln 
65                  70                  75                  80  


Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr 
                85                  90                  95      


Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp 
            100                 105                 110         


Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr 
        115                 120                 125             


Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys 
    130                 135                 140                 


Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His 
                165                 170                 175     


Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys 
            180                 185                 190         


Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val 
        195                 200                 205             


Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn 
    210                 215                 220                 


Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp 
225                 230                 235                 240 


Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro 
                245                 250                 255     


Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu 
            260                 265                 270         


Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr 
        275                 280                 285             


Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys 
    290                 295                 300                 


Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly 
305                 310                 315                 320 


Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe 
                325                 330                 335     


Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg 
            340                 345                 350         


Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly 
        355                 360                 365             


Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg 
    370                 375                 380                 


Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu 
385                 390                 395                 400 


Ile Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro 
                405                 410                 415     


Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser 
            420                 425                 430         


Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg 
        435                 440                 445             


Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu 
    450                 455                 460                 


Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser 
465                 470                 475                 480 


Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu 
                485                 490                 495     


Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala 
            500                 505                 510         


Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys 
        515                 520                 525             


Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala 
    530                 535                 540                 


Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala 
545                 550                 555                 560 


Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro 
                565                 570                 575     


Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu 
            580                 585                 590         


Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser 
        595                 600                 605             


Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu 
    610                 615                 620                 


Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp 
625                 630                 635                 640 


Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr 
                645                 650                 655     


Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly 
            660                 665                 670         


Ala Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala 
        675                 680                 685             


Arg Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala 
    690                 695                 700                 


Val Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile 
705                 710                 715                 720 


Cys Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser 
                725                 730                 735     


Ile Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr 
            740                 745                 750         


Pro Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys 
        755                 760                 765             


Cys Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser 
    770                 775                 780                 


Leu Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser 
785                 790                 795                 800 


Arg Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu 
                805                 810                 815     


Leu Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys 
            820                 825                 830         


Asp Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu 
        835                 840                 845             


Asn Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys 
    850                 855                 860                 


Glu Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu 
865                 870                 875                 880 


Val Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile 
                885                 890                 895     


Lys Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr 
            900                 905                 910         


Ile Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp 
        915                 920                 925             


Val Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln 
    930                 935                 940                 


Met Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu 
945                 950                 955                 960 


Asp Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu 
                965                 970                 975     


Tyr Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met 
            980                 985                 990         


Gln Leu Cys Ser Gln Ala Ala Glu  Glu Leu Ile Thr Arg  Ile Cys Asp 
        995                 1000                 1005             


Ala Ala  Thr Ile His Cys Leu  Leu Glu Gln Glu Leu  Ala His Ala 
    1010                 1015                 1020             


Val Asn  Ala Cys Ser His Ala  Leu Asn Lys Ala Asn  Pro Arg Cys 
    1025                 1030                 1035             


Pro Glu  Ser Leu Thr Arg Asp  Thr Ala Thr Glu Ile  Ala Ile Asn 
    1040                 1045                 1050             


Val Lys  Ala Leu Tyr Asn Glu  Thr Glu Ser Leu Leu  Val Gly Arg 
    1055                 1060                 1065             


Val Pro  Leu Gln Leu Glu Ser  Pro His Glu Glu Arg  Val Ser Asn 
    1070                 1075                 1080             


Ala Leu  His Ser Val Glu Val  Glu Leu Gln Lys Leu  Thr Glu Ile 
    1085                 1090                 1095             


Pro Trp  Leu Tyr Tyr Ile Leu  His Pro Asn Glu Asp  Glu Glu Pro 
    1100                 1105                 1110             


Pro Met  Asp Cys Thr Lys Arg  Asn Asn Arg Ser Thr  Val Phe Arg 
    1115                 1120                 1125             


Ile Val  Pro Lys Phe Lys Lys  Glu Lys Val Gln Lys  Gln Lys Thr 
    1130                 1135                 1140             


Ser Ser  Gln Pro Gly Ser Gly  Asp Thr Glu Ser Gly  Ser Cys Glu 
    1145                 1150                 1155             


Ala Asn  Ser Pro Gly Asn 
    1160                 


<210>  66
<211>  1220
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Gly Ala Gly Gly Gln His His Pro Pro Gly Ala Ala Gly Gly 
1               5                   10                  15      


Ala Ala Ala Gly Ala Gly Ala Ala Val Thr Ser Ala Ala Ala Ser Ala 
            20                  25                  30          


Gly Pro Gly Glu Asp Ser Ser Asp Ser Glu Ala Glu Gln Glu Gly Pro 
        35                  40                  45              


Gln Lys Leu Ile Arg Lys Val Ser Thr Ser Gly Gln Ile Arg Thr Lys 
    50                  55                  60                  


Thr Ser Ile Lys Glu Gly Gln Leu Leu Lys Gln Thr Ser Ser Phe Gln 
65                  70                  75                  80  


Arg Trp Lys Lys Arg Tyr Phe Lys Leu Arg Gly Arg Thr Leu Tyr Tyr 
                85                  90                  95      


Ala Lys Asp Ser Lys Ser Leu Ile Phe Asp Glu Val Asp Leu Ser Asp 
            100                 105                 110         


Ala Ser Val Ala Glu Ala Ser Thr Lys Asn Ala Asn Asn Ser Phe Thr 
        115                 120                 125             


Ile Ile Thr Pro Phe Arg Arg Leu Met Leu Cys Ala Glu Asn Arg Lys 
    130                 135                 140                 


Glu Met Glu Asp Trp Ile Ser Ser Leu Lys Ser Val Gln Thr Arg Glu 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Gln Phe Asn Val Glu His Phe Ser Gly Met His 
                165                 170                 175     


Asn Trp Tyr Ala Cys Ser His Ala Arg Pro Thr Phe Cys Asn Val Cys 
            180                 185                 190         


Arg Glu Ser Leu Ser Gly Val Thr Ser His Gly Leu Ser Cys Glu Val 
        195                 200                 205             


Cys Lys Phe Lys Ala His Lys Arg Cys Ala Val Arg Ala Thr Asn Asn 
    210                 215                 220                 


Cys Lys Trp Thr Thr Leu Ala Ser Ile Gly Lys Asp Ile Ile Glu Asp 
225                 230                 235                 240 


Glu Asp Gly Val Ala Met Pro His Gln Trp Leu Glu Gly Asn Leu Pro 
                245                 250                 255     


Val Ser Ala Lys Cys Ala Val Cys Asp Lys Thr Cys Gly Ser Val Leu 
            260                 265                 270         


Arg Leu Gln Asp Trp Lys Cys Leu Trp Cys Lys Thr Met Val His Thr 
        275                 280                 285             


Ala Cys Lys Asp Leu Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys 
    290                 295                 300                 


Val Ser Ile Ile Pro Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly 
305                 310                 315                 320 


Phe Cys Arg Ala Thr Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe 
                325                 330                 335     


Val Asn Ser Lys Ser Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg 
            340                 345                 350         


Phe Lys Gln Leu Leu Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly 
        355                 360                 365             


Gly Pro His Leu Gly Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg 
    370                 375                 380                 


Ile Leu Val Cys Gly Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu 
385                 390                 395                 400 


Ile Asp Lys Leu Asn Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro 
                405                 410                 415     


Leu Gly Thr Gly Asn Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser 
            420                 425                 430         


Tyr Asp Asp Asp Thr Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg 
        435                 440                 445             


Ala Ser Thr Lys Met Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu 
    450                 455                 460                 


Lys Leu Pro Pro Lys Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser 
465                 470                 475                 480 


Glu Glu Phe Tyr Met Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu 
                485                 490                 495     


Thr Lys Ile Leu Asn Ser Asp Glu His Ala Val Val Ile Ser Ser Ala 
            500                 505                 510         


Lys Thr Leu Cys Glu Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys 
        515                 520                 525             


Thr Tyr Asp Lys Thr Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala 
    530                 535                 540                 


Ser Lys Cys Ser Val Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala 
545                 550                 555                 560 


Leu His Thr Asp Ser Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro 
                565                 570                 575     


Leu Ile Val Glu Glu Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu 
            580                 585                 590         


Gly Glu Ser Lys Glu Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser 
        595                 600                 605             


Gln Lys Ala Val Lys Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu 
    610                 615                 620                 


Lys Lys Ala Val Arg Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp 
625                 630                 635                 640 


Asp Pro Thr Val His Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr 
                645                 650                 655     


Asp Ser Thr Glu Thr Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly 
            660                 665                 670         


Ala Lys Glu Ser Ile Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala 
        675                 680                 685             


Arg Ala Ser Tyr Gly His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala 
    690                 695                 700                 


Val Ala Ala Ser Lys Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile 
705                 710                 715                 720 


Cys Pro Gly Leu Arg Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser 
                725                 730                 735     


Ile Ile Asn Lys Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr 
            740                 745                 750         


Pro Phe Ile Asp Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys 
        755                 760                 765             


Cys Val Met Asn Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser 
    770                 775                 780                 


Leu Glu Phe Asn Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser 
785                 790                 795                 800 


Arg Thr Lys Asn Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu 
                805                 810                 815     


Leu Gln Arg Ser Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys 
            820                 825                 830         


Asp Gly Gln Tyr Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu 
        835                 840                 845             


Asn Ile Pro Ser Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys 
    850                 855                 860                 


Glu Asp Asp Ile Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu 
865                 870                 875                 880 


Val Val Ala Ile Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile 
                885                 890                 895     


Lys Leu Gln His His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr 
            900                 905                 910         


Ile Phe Gly Asp Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp 
        915                 920                 925             


Val Gln Pro Pro Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln 
    930                 935                 940                 


Met Leu Thr Arg Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu 
945                 950                 955                 960 


Asp Lys Gln Lys Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu 
                965                 970                 975     


Tyr Ile His His Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met 
            980                 985                 990         


Gln Leu Cys Ser Gln Ala Ala Glu  Glu Leu Ile Thr Arg  Ile Cys Asp 
        995                 1000                 1005             


Ala Ala  Thr Ile His Cys Leu  Leu Glu Gln Glu Leu  Ala His Ala 
    1010                 1015                 1020             


Val Asn  Ala Cys Ser His Ala  Leu Asn Lys Ala Asn  Pro Arg Cys 
    1025                 1030                 1035             


Pro Glu  Ser Leu Thr Arg Asp  Thr Ala Thr Glu Ile  Ala Ile Asn 
    1040                 1045                 1050             


Val Lys  Ala Leu Tyr Asn Glu  Thr Glu Ser Leu Leu  Val Gly Arg 
    1055                 1060                 1065             


Val Pro  Leu Gln Leu Glu Ser  Pro His Glu Glu Arg  Val Ser Asn 
    1070                 1075                 1080             


Ala Leu  His Ser Val Glu Val  Glu Leu Gln Lys Leu  Thr Glu Ile 
    1085                 1090                 1095             


Pro Trp  Leu Tyr Tyr Ile Leu  His Pro Asn Glu Asp  Glu Glu Pro 
    1100                 1105                 1110             


Pro Met  Asp Cys Thr Lys Arg  Asn Asn Arg Ser Thr  Val Phe Arg 
    1115                 1120                 1125             


Ile Val  Pro Lys Phe Lys Lys  Glu Lys Val Gln Lys  Gln Lys Thr 
    1130                 1135                 1140             


Ser Ser  Gln Pro Val Gln Lys  Trp Gly Thr Glu Glu  Val Ala Ala 
    1145                 1150                 1155             


Trp Leu  Asp Leu Leu Asn Leu  Gly Glu Tyr Lys Asp  Ile Phe Ile 
    1160                 1165                 1170             


Arg His  Asp Ile Arg Gly Ala  Glu Leu Leu His Leu  Glu Arg Arg 
    1175                 1180                 1185             


Asp Leu  Lys Asp Leu Gly Ile  Pro Lys Val Gly His  Val Lys Arg 
    1190                 1195                 1200             


Ile Leu  Gln Gly Ile Lys Glu  Leu Gly Arg Ser Thr  Pro Gln Ser 
    1205                 1210                 1215             


Glu Val  
    1220 


<210>  67
<211>  1100
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Leu Cys Ala Glu Asn Arg Lys Glu Met Glu Asp Trp Ile Ser Ser 
1               5                   10                  15      


Leu Lys Ser Val Gln Thr Arg Glu Pro Tyr Glu Val Ala Gln Phe Asn 
            20                  25                  30          


Val Glu His Phe Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala 
        35                  40                  45              


Arg Pro Thr Phe Cys Asn Val Cys Arg Glu Ser Leu Ser Gly Val Thr 
    50                  55                  60                  


Ser His Gly Leu Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg 
65                  70                  75                  80  


Cys Ala Val Arg Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser 
                85                  90                  95      


Ile Gly Lys Asp Ile Ile Glu Asp Glu Asp Gly Val Ala Met Pro His 
            100                 105                 110         


Gln Trp Leu Glu Gly Asn Leu Pro Val Ser Ala Lys Cys Ala Val Cys 
        115                 120                 125             


Asp Lys Thr Cys Gly Ser Val Leu Arg Leu Gln Asp Trp Lys Cys Leu 
    130                 135                 140                 


Trp Cys Lys Thr Met Val His Thr Ala Cys Lys Asp Leu Tyr His Pro 
145                 150                 155                 160 


Ile Cys Pro Leu Gly Gln Cys Lys Val Ser Ile Ile Pro Pro Ile Ala 
                165                 170                 175     


Leu Asn Ser Thr Asp Ser Asp Gly Phe Cys Arg Ala Thr Phe Ser Phe 
            180                 185                 190         


Cys Val Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp Asn 
        195                 200                 205             


Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro Ala 
    210                 215                 220                 


Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg Leu 
225                 230                 235                 240 


Phe Gln Lys Phe Asp Asn Phe Arg Ile Leu Val Cys Gly Gly Asp Gly 
                245                 250                 255     


Ser Val Gly Trp Val Leu Ser Glu Ile Asp Lys Leu Asn Leu Asn Lys 
            260                 265                 270         


Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
        275                 280                 285             


Arg Val Leu Gly Trp Gly Gly Ser Tyr Asp Asp Asp Thr Gln Leu Pro 
    290                 295                 300                 


Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp Arg 
305                 310                 315                 320 


Trp Ser Ile Met Thr Tyr Glu Leu Lys Leu Pro Pro Lys Ala Ser Leu 
                325                 330                 335     


Leu Pro Gly Pro Pro Glu Ala Ser Glu Glu Phe Tyr Met Thr Ile Tyr 
            340                 345                 350         


Glu Asp Ser Val Ala Thr His Leu Thr Lys Ile Leu Asn Ser Asp Glu 
        355                 360                 365             


His Ala Val Val Ile Ser Ser Ala Lys Thr Leu Cys Glu Thr Val Lys 
    370                 375                 380                 


Asp Phe Val Ala Lys Val Glu Lys Thr Tyr Asp Lys Thr Leu Glu Asn 
385                 390                 395                 400 


Ala Val Val Ala Asp Ala Val Ala Ser Lys Cys Ser Val Leu Asn Glu 
                405                 410                 415     


Lys Leu Glu Gln Leu Leu Gln Ala Leu His Thr Asp Ser Gln Ala Ala 
            420                 425                 430         


Pro Val Leu Pro Gly Leu Ser Pro Leu Ile Val Glu Glu Asp Ala Val 
        435                 440                 445             


Glu Ser Ser Ser Glu Glu Ser Leu Gly Glu Ser Lys Glu Gln Leu Gly 
    450                 455                 460                 


Asp Asp Val Thr Lys Pro Ser Ser Gln Lys Ala Val Lys Pro Arg Glu 
465                 470                 475                 480 


Ile Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Val Arg Gln Val Ile 
                485                 490                 495     


Glu Glu Ala Gly Lys Val Met Asp Asp Pro Thr Val His Pro Cys Glu 
            500                 505                 510         


Pro Ala Asn Gln Ser Ser Asp Tyr Asp Ser Thr Glu Thr Asp Glu Ser 
        515                 520                 525             


Lys Glu Glu Ala Lys Asp Asp Gly Ala Lys Glu Ser Ile Thr Val Lys 
    530                 535                 540                 


Thr Ala Pro Arg Ser Pro Asp Ala Arg Ala Ser Tyr Gly His Ser Gln 
545                 550                 555                 560 


Thr Asp Ser Val Pro Gly Pro Ala Val Ala Ala Ser Lys Glu Asn Leu 
                565                 570                 575     


Pro Val Leu Asn Thr Arg Ile Ile Cys Pro Gly Leu Arg Ala Gly Leu 
            580                 585                 590         


Ala Ala Ser Ile Ala Gly Ser Ser Ile Ile Asn Lys Met Leu Leu Ala 
        595                 600                 605             


Asn Ile Asp Pro Phe Gly Ala Thr Pro Phe Ile Asp Pro Asp Leu Asp 
    610                 615                 620                 


Ser Val Asp Gly Tyr Ser Glu Lys Cys Val Met Asn Asn Tyr Phe Gly 
625                 630                 635                 640 


Ile Gly Leu Asp Ala Lys Ile Ser Leu Glu Phe Asn Asn Lys Arg Glu 
                645                 650                 655     


Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn Leu Met Trp Tyr 
            660                 665                 670         


Gly Val Leu Gly Thr Arg Glu Leu Leu Gln Arg Ser Tyr Lys Asn Leu 
        675                 680                 685             


Glu Gln Arg Val Gln Leu Glu Cys Asp Gly Gln Tyr Ile Pro Leu Pro 
    690                 695                 700                 


Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser Tyr Ala Gly Gly 
705                 710                 715                 720 


Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Ile Phe Ala Ala Pro 
                725                 730                 735     


Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Ile Phe Asp Ser Met 
            740                 745                 750         


Gln Met Ala Val Ser Arg Val Ile Lys Leu Gln His His Arg Ile Ala 
        755                 760                 765             


Gln Cys Arg Thr Val Lys Ile Thr Ile Phe Gly Asp Glu Gly Val Pro 
    770                 775                 780                 


Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly Ile Ile Lys 
785                 790                 795                 800 


Ile Val His Lys Asn Arg Ala Gln Met Leu Thr Arg Asp Arg Ala Phe 
                805                 810                 815     


Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys Cys Asp Ser Gly 
            820                 825                 830         


Lys Pro Val Leu Arg Thr His Leu Tyr Ile His His Ala Ile Asp Leu 
        835                 840                 845             


Ala Thr Glu Glu Val Ser Gln Met Gln Leu Cys Ser Gln Ala Ala Glu 
    850                 855                 860                 


Glu Leu Ile Thr Arg Ile Cys Asp Ala Ala Thr Ile His Cys Leu Leu 
865                 870                 875                 880 


Glu Gln Glu Leu Ala His Ala Val Asn Ala Cys Ser His Ala Leu Asn 
                885                 890                 895     


Lys Ala Asn Pro Arg Cys Pro Glu Ser Leu Thr Arg Asp Thr Ala Thr 
            900                 905                 910         


Glu Ile Ala Ile Asn Val Lys Ala Leu Tyr Asn Glu Thr Glu Ser Leu 
        915                 920                 925             


Leu Val Gly Arg Val Pro Leu Gln Leu Glu Ser Pro His Glu Glu Arg 
    930                 935                 940                 


Val Ser Asn Ala Leu His Ser Val Glu Val Glu Leu Gln Lys Leu Thr 
945                 950                 955                 960 


Glu Ile Pro Trp Leu Tyr Tyr Ile Leu His Pro Asn Glu Asp Glu Glu 
                965                 970                 975     


Pro Pro Met Asp Cys Thr Lys Arg Asn Asn Arg Ser Thr Val Phe Arg 
            980                 985                 990         


Ile Val Pro Lys Phe Lys Lys Glu  Lys Val Gln Lys Gln  Lys Thr Ser 
        995                 1000                 1005             


Ser Gln  Pro Val Gln Lys Trp  Gly Thr Glu Glu Val  Ala Ala Trp 
    1010                 1015                 1020             


Leu Asp  Leu Leu Asn Leu Gly  Glu Tyr Lys Asp Ile  Phe Ile Arg 
    1025                 1030                 1035             


His Asp  Ile Arg Gly Ala Glu  Leu Leu His Leu Glu  Arg Arg Asp 
    1040                 1045                 1050             


Leu Lys  Asn Thr Val Gly Glu  Lys Arg Asp Thr Lys  Glu Asn Gly 
    1055                 1060                 1065             


Lys His  Met Asp Leu Gly Ile  Pro Lys Val Gly His  Val Lys Arg 
    1070                 1075                 1080             


Ile Leu  Gln Gly Ile Lys Glu  Leu Gly Arg Ser Thr  Pro Gln Ser 
    1085                 1090                 1095             


Glu Val  
    1100 


<210>  68
<211>  1084
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Cys Ala Glu Asn Arg Lys Glu Met Glu Asp Trp Ile Ser Ser 
1               5                   10                  15      


Leu Lys Ser Val Gln Thr Arg Glu Pro Tyr Glu Val Ala Gln Phe Asn 
            20                  25                  30          


Val Glu His Phe Ser Gly Met His Asn Trp Tyr Ala Cys Ser His Ala 
        35                  40                  45              


Arg Pro Thr Phe Cys Asn Val Cys Arg Glu Ser Leu Ser Gly Val Thr 
    50                  55                  60                  


Ser His Gly Leu Ser Cys Glu Val Cys Lys Phe Lys Ala His Lys Arg 
65                  70                  75                  80  


Cys Ala Val Arg Ala Thr Asn Asn Cys Lys Trp Thr Thr Leu Ala Ser 
                85                  90                  95      


Ile Gly Lys Asp Ile Ile Glu Asp Glu Asp Gly Val Ala Met Pro His 
            100                 105                 110         


Gln Trp Leu Glu Gly Asn Leu Pro Val Ser Ala Lys Cys Ala Val Cys 
        115                 120                 125             


Asp Lys Thr Cys Gly Ser Val Leu Arg Leu Gln Asp Trp Lys Cys Leu 
    130                 135                 140                 


Trp Cys Lys Thr Met Val His Thr Ala Cys Lys Asp Leu Tyr His Pro 
145                 150                 155                 160 


Ile Cys Pro Leu Gly Gln Cys Lys Val Ser Ile Ile Pro Pro Ile Ala 
                165                 170                 175     


Leu Asn Ser Thr Asp Ser Asp Gly Phe Cys Arg Ala Thr Phe Ser Phe 
            180                 185                 190         


Cys Val Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser Gly Asp Asn 
        195                 200                 205             


Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu Asn Pro Ala 
    210                 215                 220                 


Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly Leu Arg Leu 
225                 230                 235                 240 


Phe Gln Lys Phe Asp Asn Phe Arg Ile Leu Val Cys Gly Gly Asp Gly 
                245                 250                 255     


Ser Val Gly Trp Val Leu Ser Glu Ile Asp Lys Leu Asn Leu Asn Lys 
            260                 265                 270         


Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala 
        275                 280                 285             


Arg Val Leu Gly Trp Gly Gly Ser Tyr Asp Asp Asp Thr Gln Leu Pro 
    290                 295                 300                 


Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met Leu Asp Arg 
305                 310                 315                 320 


Trp Ser Ile Met Thr Tyr Glu Leu Lys Leu Pro Pro Lys Ala Ser Leu 
                325                 330                 335     


Leu Pro Gly Pro Pro Glu Ala Ser Glu Glu Phe Tyr Met Thr Ile Tyr 
            340                 345                 350         


Glu Asp Ser Val Ala Thr His Leu Thr Lys Ile Leu Asn Ser Asp Glu 
        355                 360                 365             


His Ala Val Val Ile Ser Ser Ala Lys Thr Leu Cys Glu Thr Val Lys 
    370                 375                 380                 


Asp Phe Val Ala Lys Val Glu Lys Thr Tyr Asp Lys Thr Leu Glu Asn 
385                 390                 395                 400 


Ala Val Val Ala Asp Ala Val Ala Ser Lys Cys Ser Val Leu Asn Glu 
                405                 410                 415     


Lys Leu Glu Gln Leu Leu Gln Ala Leu His Thr Asp Ser Gln Ala Ala 
            420                 425                 430         


Pro Val Leu Pro Gly Leu Ser Pro Leu Ile Val Glu Glu Asp Ala Val 
        435                 440                 445             


Glu Ser Ser Ser Glu Glu Ser Leu Gly Glu Ser Lys Glu Gln Leu Gly 
    450                 455                 460                 


Asp Asp Val Thr Lys Pro Ser Ser Gln Lys Ala Val Lys Pro Arg Glu 
465                 470                 475                 480 


Ile Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Val Arg Gln Val Ile 
                485                 490                 495     


Glu Glu Ala Gly Lys Val Met Asp Asp Pro Thr Val His Pro Cys Glu 
            500                 505                 510         


Pro Ala Asn Gln Ser Ser Asp Tyr Asp Ser Thr Glu Thr Asp Glu Ser 
        515                 520                 525             


Lys Glu Glu Ala Lys Asp Asp Gly Ala Lys Glu Ser Ile Thr Val Lys 
    530                 535                 540                 


Thr Ala Pro Arg Ser Pro Asp Ala Arg Ala Ser Tyr Gly His Ser Gln 
545                 550                 555                 560 


Thr Asp Ser Val Pro Gly Pro Ala Val Ala Ala Ser Lys Glu Asn Leu 
                565                 570                 575     


Pro Val Leu Asn Thr Arg Ile Ile Cys Pro Gly Leu Arg Ala Gly Leu 
            580                 585                 590         


Ala Ala Ser Ile Ala Gly Ser Ser Ile Ile Asn Lys Met Leu Leu Ala 
        595                 600                 605             


Asn Ile Asp Pro Phe Gly Ala Thr Pro Phe Ile Asp Pro Asp Leu Asp 
    610                 615                 620                 


Ser Val Asp Gly Tyr Ser Glu Lys Cys Val Met Asn Asn Tyr Phe Gly 
625                 630                 635                 640 


Ile Gly Leu Asp Ala Lys Ile Ser Leu Glu Phe Asn Asn Lys Arg Glu 
                645                 650                 655     


Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn Leu Met Trp Tyr 
            660                 665                 670         


Gly Val Leu Gly Thr Arg Glu Leu Leu Gln Arg Ser Tyr Lys Asn Leu 
        675                 680                 685             


Glu Gln Arg Val Gln Leu Glu Cys Asp Gly Gln Tyr Ile Pro Leu Pro 
    690                 695                 700                 


Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser Tyr Ala Gly Gly 
705                 710                 715                 720 


Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Ile Phe Ala Ala Pro 
                725                 730                 735     


Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Ile Phe Asp Ser Met 
            740                 745                 750         


Gln Met Ala Val Ser Arg Val Ile Lys Leu Gln His His Arg Ile Ala 
        755                 760                 765             


Gln Cys Arg Thr Val Lys Ile Thr Ile Phe Gly Asp Glu Gly Val Pro 
    770                 775                 780                 


Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly Ile Ile Lys 
785                 790                 795                 800 


Ile Val His Lys Asn Arg Ala Gln Met Leu Thr Arg Asp Arg Ala Phe 
                805                 810                 815     


Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys Cys Asp Ser Gly 
            820                 825                 830         


Lys Pro Val Leu Arg Thr His Leu Tyr Ile His His Ala Ile Asp Leu 
        835                 840                 845             


Ala Thr Glu Glu Val Ser Gln Met Gln Leu Cys Ser Gln Ala Ala Glu 
    850                 855                 860                 


Glu Leu Ile Thr Arg Ile Cys Asp Ala Ala Thr Ile His Cys Leu Leu 
865                 870                 875                 880 


Glu Gln Glu Leu Ala His Ala Val Asn Ala Cys Ser His Ala Leu Asn 
                885                 890                 895     


Lys Ala Asn Pro Arg Cys Pro Glu Ser Leu Thr Arg Asp Thr Ala Thr 
            900                 905                 910         


Glu Ile Ala Ile Asn Val Lys Ala Leu Tyr Asn Glu Thr Glu Ser Leu 
        915                 920                 925             


Leu Val Gly Arg Val Pro Leu Gln Leu Glu Ser Pro His Glu Glu Arg 
    930                 935                 940                 


Val Ser Asn Ala Leu His Ser Val Glu Val Glu Leu Gln Lys Leu Thr 
945                 950                 955                 960 


Glu Ile Pro Trp Leu Tyr Tyr Ile Leu His Pro Asn Glu Asp Glu Glu 
                965                 970                 975     


Pro Pro Met Asp Cys Thr Lys Arg Asn Asn Arg Ser Thr Val Phe Arg 
            980                 985                 990         


Ile Val Pro Lys Phe Lys Lys Glu  Lys Val Gln Lys Gln  Lys Thr Ser 
        995                 1000                 1005             


Ser Gln  Pro Val Gln Lys Trp  Gly Thr Glu Glu Val  Ala Ala Trp 
    1010                 1015                 1020             


Leu Asp  Leu Leu Asn Leu Gly  Glu Tyr Lys Asp Ile  Phe Ile Arg 
    1025                 1030                 1035             


His Asp  Ile Arg Gly Ala Glu  Leu Leu His Leu Glu  Arg Arg Asp 
    1040                 1045                 1050             


Leu Lys  Asp Leu Gly Ile Pro  Lys Val Gly His Val  Lys Arg Ile 
    1055                 1060                 1065             


Leu Gln  Gly Ile Lys Glu Leu  Gly Arg Ser Thr Pro  Gln Ser Glu 
    1070                 1075                 1080             


Val 
    


<210>  69
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Trp Asn Ile Ser Gln Gly Cys Thr Thr Gly Thr Pro Ala Pro Thr 
1               5                   10                  15      


Pro Asp Pro Pro Ser Val Thr Cys Ala Glu Arg Val Phe Leu Glu Ser 
            20                  25                  30          


Pro Pro Met Ala Cys Pro Ala Lys Val His Thr Ala Cys Lys Asp Leu 
        35                  40                  45              


Tyr His Pro Ile Cys Pro Leu Gly Gln Cys Lys Val Ser Ile Ile Pro 
    50                  55                  60                  


Pro Ile Ala Leu Asn Ser Thr Asp Ser Asp Gly Phe Cys Arg Ala Thr 
65                  70                  75                  80  


Phe Ser Phe Cys Val Ser Pro Leu Leu Val Phe Val Asn Ser Lys Ser 
                85                  90                  95      


Gly Asp Asn Gln Gly Val Lys Phe Leu Arg Arg Phe Lys Gln Leu Leu 
            100                 105                 110         


Asn Pro Ala Gln Val Phe Asp Leu Met Asn Gly Gly Pro His Leu Gly 
        115                 120                 125             


Leu Arg Leu Phe Gln Lys Phe Asp Asn Phe Arg Ile Leu Val Cys Gly 
    130                 135                 140                 


Gly Asp Gly Ser Val Gly Trp Val Leu Ser Glu Ile Asp Lys Leu Asn 
145                 150                 155                 160 


Leu Asn Lys Gln Cys Gln Leu Gly Val Leu Pro Leu Gly Thr Gly Asn 
                165                 170                 175     


Asp Leu Ala Arg Val Leu Gly Trp Gly Gly Ser Tyr Asp Asp Asp Thr 
            180                 185                 190         


Gln Leu Pro Gln Ile Leu Glu Lys Leu Glu Arg Ala Ser Thr Lys Met 
        195                 200                 205             


Leu Asp Arg Trp Ser Ile Met Thr Tyr Glu Leu Lys Leu Pro Pro Lys 
    210                 215                 220                 


Ala Ser Leu Leu Pro Gly Pro Pro Glu Ala Ser Glu Glu Phe Tyr Met 
225                 230                 235                 240 


Thr Ile Tyr Glu Asp Ser Val Ala Thr His Leu Thr Lys Ile Leu Asn 
                245                 250                 255     


Ser Asp Glu His Ala Val Val Ile Ser Ser Ala Lys Thr Leu Cys Glu 
            260                 265                 270         


Thr Val Lys Asp Phe Val Ala Lys Val Glu Lys Thr Tyr Asp Lys Thr 
        275                 280                 285             


Leu Glu Asn Ala Val Val Ala Asp Ala Val Ala Ser Lys Cys Ser Val 
    290                 295                 300                 


Leu Asn Glu Lys Leu Glu Gln Leu Leu Gln Ala Leu His Thr Asp Ser 
305                 310                 315                 320 


Gln Ala Ala Pro Val Leu Pro Gly Leu Ser Pro Leu Ile Val Glu Glu 
                325                 330                 335     


Asp Ala Val Glu Ser Ser Ser Glu Glu Ser Leu Gly Glu Ser Lys Glu 
            340                 345                 350         


Gln Leu Gly Asp Asp Val Thr Lys Pro Ser Ser Gln Lys Ala Val Lys 
        355                 360                 365             


Pro Arg Glu Ile Met Leu Arg Ala Asn Ser Leu Lys Lys Ala Val Arg 
    370                 375                 380                 


Gln Val Ile Glu Glu Ala Gly Lys Val Met Asp Asp Pro Thr Val His 
385                 390                 395                 400 


Pro Cys Glu Pro Ala Asn Gln Ser Ser Asp Tyr Asp Ser Thr Glu Thr 
                405                 410                 415     


Asp Glu Ser Lys Glu Glu Ala Lys Asp Asp Gly Ala Lys Glu Ser Ile 
            420                 425                 430         


Thr Val Lys Thr Ala Pro Arg Ser Pro Asp Ala Arg Ala Ser Tyr Gly 
        435                 440                 445             


His Ser Gln Thr Asp Ser Val Pro Gly Pro Ala Val Ala Ala Ser Lys 
    450                 455                 460                 


Glu Asn Leu Pro Val Leu Asn Thr Arg Ile Ile Cys Pro Gly Leu Arg 
465                 470                 475                 480 


Ala Gly Leu Ala Ala Ser Ile Ala Gly Ser Ser Ile Ile Asn Lys Met 
                485                 490                 495     


Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr Pro Phe Ile Asp Pro 
            500                 505                 510         


Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys Cys Val Met Asn Asn 
        515                 520                 525             


Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Glu Phe Asn Asn 
    530                 535                 540                 


Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn Leu 
545                 550                 555                 560 


Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu Leu Gln Arg Ser Tyr 
                565                 570                 575     


Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys Asp Gly Gln Tyr Ile 
            580                 585                 590         


Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser Tyr 
        595                 600                 605             


Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Ile Phe 
    610                 615                 620                 


Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Ile Phe 
625                 630                 635                 640 


Asp Ser Met Gln Met Ala Val Ser Arg Val Ile Lys Leu Gln His His 
                645                 650                 655     


Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr Ile Phe Gly Asp Glu 
            660                 665                 670         


Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro Gly 
        675                 680                 685             


Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln Met Leu Thr Arg Asp 
    690                 695                 700                 


Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys Cys 
705                 710                 715                 720 


Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu Tyr Ile His His Ala 
                725                 730                 735     


Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met Gln Leu Cys Ser Gln 
            740                 745                 750         


Ala Ala Glu Glu Leu Ile Thr Arg Ile Cys Asp Ala Ala Thr Ile His 
        755                 760                 765             


Cys Leu Leu Glu Gln Glu Leu Ala His Ala Val Asn Ala Cys Ser His 
    770                 775                 780                 


Ala Leu Asn Lys Ala Asn Pro Arg Cys Pro Glu Ser Leu Thr Arg Asp 
785                 790                 795                 800 


Thr Ala Thr Glu Ile Ala Ile Asn Val Lys Ala Leu Tyr Asn Glu Thr 
                805                 810                 815     


Glu Ser Leu Leu Val Gly Arg Val Pro Leu Gln Leu Glu Ser Pro His 
            820                 825                 830         


Glu Glu Arg Val Ser Asn Ala Leu His Ser Val Glu Val Glu Leu Gln 
        835                 840                 845             


Lys Leu Thr Glu Ile Pro Trp Leu Tyr Tyr Ile Leu His Pro Asn Glu 
    850                 855                 860                 


Asp Glu Glu Pro Pro Met Asp Cys Thr Lys Arg Asn Asn Arg Ser Thr 
865                 870                 875                 880 


Val Phe Arg Ile Val Pro Lys Phe Lys Lys Glu Lys Val Gln Lys Gln 
                885                 890                 895     


Lys Thr Ser Ser Gln Pro Gly Ser Gly Asp Thr Glu Ser Gly Ser Cys 
            900                 905                 910         


Glu Ala Asn Ser Pro Gly Asn 
        915                 


<210>  70
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys 
1               5                   10                  15      


Ala Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser 
        35                  40                  45              


Ala Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln 
    50                  55                  60                  


Glu Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu 
65                  70                  75                  80  


Leu Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala 
                85                  90                  95      


Gly Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser 
            100                 105                 110         


Ser Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val 
        115                 120                 125             


Val Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg 
    130                 135                 140                 


Gln Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met 
145                 150                 155                 160 


Asp Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln 
                165                 170                 175     


Thr Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr 
            180                 185                 190         


Gly Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val 
        195                 200                 205             


Leu Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr 
    210                 215                 220                 


Leu Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly 
225                 230                 235                 240 


Glu Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met 
                245                 250                 255     


Met Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys 
            260                 265                 270         


Phe Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr 
        275                 280                 285             


Phe Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile 
    290                 295                 300                 


Met Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp 
305                 310                 315                 320 


Ile Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu 
                325                 330                 335     


Lys Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln 
            340                 345                 350         


Met Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg 
        355                 360                 365             


Cys Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly 
    370                 375                 380                 


Ile Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys 
385                 390                 395                 400 


Met Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val 
                405                 410                 415     


Phe Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro 
            420                 425                 430         


Asn Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln 
        435                 440                 445             


Arg Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val 
    450                 455                 460                 


Pro Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val 
465                 470                 475                 480 


Lys Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val 
                485                 490                 495     


Met Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys 
            500                 505                 510         


Asn Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala 
        515                 520                 525             


Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His 
    530                 535                 540                 


Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp 
545                 550                 555                 560 


Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val 
                565                 570                 575     


Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu 
            580                 585                 590         


Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro 
        595                 600                 605             


Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala 
    610                 615                 620                 


Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu 
625                 630                 635                 640 


Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly 
                645                 650                 655     


Thr Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu 
            660                 665                 670         


Asn Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys 
        675                 680                 685             


Glu Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val 
    690                 695                 700                 


His Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln 
705                 710                 715                 720 


Ile Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala 
                725                 730                 735     


Gln Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro 
            740                 745                 750         


Glu Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly 
        755                 760                 765             


His Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val 
    770                 775                 780                 


Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu 
785                 790                 795                 800 


Arg Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His 
                805                 810                 815     


Trp Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser 
            820                 825                 830         


Gln Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile 
        835                 840                 845             


Pro Ala Leu Asp Asn Phe Leu Asp Lys Leu 
    850                 855             


<210>  71
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Cys Gly Thr Gly Gly Thr Asp Ser Lys Thr Arg Arg Pro Pro His 
1               5                   10                  15      


Arg Ala Ser Phe Leu Lys Arg Leu Glu Ser Lys Pro Leu Lys Met Ala 
            20                  25                  30          


Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala Thr Phe 
        35                  40                  45              


Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val Leu Lys 
    50                  55                  60                  


Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr Gly Lys 
65                  70                  75                  80  


His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe Thr Gly 
                85                  90                  95      


Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp Val Pro 
            100                 105                 110         


Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp Gly Tyr 
        115                 120                 125             


Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu Arg Leu 
    130                 135                 140                 


Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp Cys Gly 
145                 150                 155                 160 


Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu Ala Ala 
                165                 170                 175     


Val Ala Ile Lys Ala Met Ala Lys 
            180                 


<210>  72
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala 
1               5                   10                  15      


Thr Phe Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Arg Leu Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp 
        115                 120                 125             


Cys Gly Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu 
    130                 135                 140                 


Ala Ala Val Ala Ile Lys Ala Met Ala Lys 
145                 150                 


<210>  73
<211>  2477
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 
    2165                 2170                 2175             


His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 
    2180                 2185                 2190             


Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 
    2195                 2200                 2205             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2210                 2215                 2220             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2225                 2230                 2235             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2240                 2245                 2250             


Thr Arg  Gly Ala Thr Tyr Asn  Ile Ile Val Glu Ala  Leu Lys Asp 
    2255                 2260                 2265             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2270                 2275                 2280             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2285                 2290                 2295             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2300                 2305                 2310             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2315                 2320                 2325             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2330                 2335                 2340             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2345                 2350                 2355             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2360                 2365                 2370             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2375                 2380                 2385             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2390                 2395                 2400             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2405                 2410                 2415             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2420                 2425                 2430             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2435                 2440                 2445             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2450                 2455                 2460             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2465                 2470                 2475         


<210>  74
<211>  2355
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2075                 2080                 2085             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2090                 2095                 2100             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2105                 2110                 2115             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2120                 2125                 2130             


Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2135                 2140                 2145             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2150                 2155                 2160             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2165                 2170                 2175             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2180                 2185                 2190             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2195                 2200                 2205             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2210                 2215                 2220             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2225                 2230                 2235             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2240                 2245                 2250             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2255                 2260                 2265             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2270                 2275                 2280             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2285                 2290                 2295             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2300                 2305                 2310             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2315                 2320                 2325             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2330                 2335                 2340             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2345                 2350                 2355 


<210>  75
<211>  2330
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Val Gln Lys Thr  Pro Phe Val 
    1985                 1990                 1995             


Thr His  Pro Gly Tyr Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly 
    2000                 2005                 2010             


Thr Ser  Gly Gln Gln Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu 
    2015                 2020                 2025             


Glu His  Gly Phe Arg Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro 
    2030                 2035                 2040             


Ile Arg  His Arg Pro Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu 
    2045                 2050                 2055             


Ala Leu  Ser Gln Thr Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr 
    2060                 2065                 2070             


Ser Glu  Tyr Ile Ile Ser Cys  His Pro Val Gly Thr  Asp Glu Glu 
    2075                 2080                 2085             


Pro Leu  Gln Phe Arg Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu 
    2090                 2095                 2100             


Thr Gly  Leu Thr Arg Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala 
    2105                 2110                 2115             


Leu Lys  Asp Gln Gln Arg His  Lys Val Arg Glu Glu  Val Val Thr 
    2120                 2125                 2130             


Val Gly  Asn Ser Val Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp 
    2135                 2140                 2145             


Ser Cys  Phe Asp Pro Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp 
    2150                 2155                 2160             


Glu Trp  Glu Arg Met Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln 
    2165                 2170                 2175             


Cys Leu  Gly Phe Gly Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg 
    2180                 2185                 2190             


Trp Cys  His Asp Asn Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp 
    2195                 2200                 2205             


Asp Arg  Gln Gly Glu Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu 
    2210                 2215                 2220             


Gly Asn  Gly Lys Gly Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr 
    2225                 2230                 2235             


Cys Tyr  Asp Asp Gly Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln 
    2240                 2245                 2250             


Lys Glu  Tyr Leu Gly Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly 
    2255                 2260                 2265             


Gln Arg  Gly Trp Arg Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu 
    2270                 2275                 2280             


Pro Ser  Pro Glu Gly Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser 
    2285                 2290                 2295             


Gln Arg  Tyr His Gln Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile 
    2300                 2305                 2310             


Glu Cys  Phe Met Pro Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser 
    2315                 2320                 2325             


Arg Glu  
    2330 


<210>  76
<211>  2296
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1895                 1900                 1905             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    1910                 1915                 1920             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    1925                 1930                 1935             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    1940                 1945                 1950             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    1955                 1960                 1965             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    1970                 1975                 1980             


Arg Pro  Tyr Pro Pro Asn Val  Gly Glu Glu Ile Gln  Ile Gly His 
    1985                 1990                 1995             


Ile Pro  Arg Glu Asp Val Asp  Tyr His Leu Tyr Pro  His Gly Pro 
    2000                 2005                 2010             


Gly Leu  Asn Pro Asn Ala Ser  Thr Gly Gln Glu Ala  Leu Ser Gln 
    2015                 2020                 2025             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2030                 2035                 2040             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2045                 2050                 2055             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2060                 2065                 2070             


Arg Gly  Ala Thr Tyr Asn Ile  Ile Val Glu Ala Leu  Lys Asp Gln 
    2075                 2080                 2085             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2090                 2095                 2100             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2105                 2110                 2115             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2120                 2125                 2130             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2135                 2140                 2145             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2150                 2155                 2160             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2165                 2170                 2175             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2180                 2185                 2190             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2195                 2200                 2205             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2210                 2215                 2220             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2225                 2230                 2235             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2240                 2245                 2250             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2255                 2260                 2265             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2270                 2275                 2280             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2285                 2290                 2295     


<210>  77
<211>  2176
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Gly Gln Glu Ala  Leu Ser Gln 
    1895                 1900                 1905             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    1910                 1915                 1920             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    1925                 1930                 1935             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    1940                 1945                 1950             


Arg Gly  Ala Thr Tyr Asn Ile  Ile Val Glu Ala Leu  Lys Asp Gln 
    1955                 1960                 1965             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    1970                 1975                 1980             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    1985                 1990                 1995             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2000                 2005                 2010             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2015                 2020                 2025             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2030                 2035                 2040             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2045                 2050                 2055             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2060                 2065                 2070             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2075                 2080                 2085             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2090                 2095                 2100             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2105                 2110                 2115             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2120                 2125                 2130             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2135                 2140                 2145             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2150                 2155                 2160             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2165                 2170                 2175     


<210>  78
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Val Ser Ile Pro Pro Arg Asn Leu Gly 
                645                 650                 655     


Tyr 
    


<210>  79
<211>  2446
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Gln Glu Ala  Leu Ser Gln 
    2165                 2170                 2175             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2180                 2185                 2190             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2195                 2200                 2205             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2210                 2215                 2220             


Arg Gly  Ala Thr Tyr Asn Ile  Ile Val Glu Ala Leu  Lys Asp Gln 
    2225                 2230                 2235             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2240                 2245                 2250             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2255                 2260                 2265             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2270                 2275                 2280             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2285                 2290                 2295             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2300                 2305                 2310             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2315                 2320                 2325             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2330                 2335                 2340             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2345                 2350                 2355             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2360                 2365                 2370             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2375                 2380                 2385             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2390                 2395                 2400             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2405                 2410                 2415             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2420                 2425                 2430             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2435                 2440                 2445     


<210>  80
<211>  2267
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Thr Ile Pro Ala  Pro Thr Asp 
    1715                 1720                 1725             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1730                 1735                 1740             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1745                 1750                 1755             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1760                 1765                 1770             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1775                 1780                 1785             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1790                 1795                 1800             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1805                 1810                 1815             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1820                 1825                 1830             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1835                 1840                 1845             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1850                 1855                 1860             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1865                 1870                 1875             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1880                 1885                 1890             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1895                 1900                 1905             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    1910                 1915                 1920             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    1925                 1930                 1935             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    1940                 1945                 1950             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    1955                 1960                 1965             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    1970                 1975                 1980             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Gly Gln Glu  Ala Leu Ser 
    1985                 1990                 1995             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2000                 2005                 2010             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2015                 2020                 2025             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2030                 2035                 2040             


Thr Arg  Gly Ala Thr Tyr Asn  Ile Ile Val Glu Ala  Leu Lys Asp 
    2045                 2050                 2055             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2060                 2065                 2070             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2075                 2080                 2085             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2090                 2095                 2100             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2105                 2110                 2115             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2120                 2125                 2130             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2135                 2140                 2145             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2150                 2155                 2160             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2165                 2170                 2175             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2180                 2185                 2190             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2195                 2200                 2205             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2210                 2215                 2220             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2225                 2230                 2235             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2240                 2245                 2250             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2255                 2260                 2265         


<210>  81
<211>  2265
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1895                 1900                 1905             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    1910                 1915                 1920             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    1925                 1930                 1935             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    1940                 1945                 1950             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    1955                 1960                 1965             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    1970                 1975                 1980             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    1985                 1990                 1995             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2000                 2005                 2010             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2015                 2020                 2025             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2030                 2035                 2040             


Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2045                 2050                 2055             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2060                 2065                 2070             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2075                 2080                 2085             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2090                 2095                 2100             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2105                 2110                 2115             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2120                 2125                 2130             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2135                 2140                 2145             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2150                 2155                 2160             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2165                 2170                 2175             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2180                 2185                 2190             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2195                 2200                 2205             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2210                 2215                 2220             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2225                 2230                 2235             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2240                 2245                 2250             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2255                 2260                 2265 


<210>  82
<211>  2240
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Thr Ile Pro Ala Pro  Thr Asp Leu 
    1625                 1630                 1635             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1640                 1645                 1650             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1655                 1660                 1665             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1670                 1675                 1680             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1685                 1690                 1695             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1700                 1705                 1710             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1715                 1720                 1725             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1730                 1735                 1740             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1745                 1750                 1755             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1760                 1765                 1770             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1775                 1780                 1785             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1790                 1795                 1800             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1805                 1810                 1815             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1820                 1825                 1830             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1835                 1840                 1845             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1850                 1855                 1860             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1865                 1870                 1875             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1880                 1885                 1890             


Pro Leu  Ile Gly Arg Lys Lys  Thr Val Gln Lys Thr  Pro Phe Val 
    1895                 1900                 1905             


Thr His  Pro Gly Tyr Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly 
    1910                 1915                 1920             


Thr Ser  Gly Gln Gln Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu 
    1925                 1930                 1935             


Glu His  Gly Phe Arg Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro 
    1940                 1945                 1950             


Ile Arg  His Arg Pro Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu 
    1955                 1960                 1965             


Ala Leu  Ser Gln Thr Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr 
    1970                 1975                 1980             


Ser Glu  Tyr Ile Ile Ser Cys  His Pro Val Gly Thr  Asp Glu Glu 
    1985                 1990                 1995             


Pro Leu  Gln Phe Arg Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu 
    2000                 2005                 2010             


Thr Gly  Leu Thr Arg Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala 
    2015                 2020                 2025             


Leu Lys  Asp Gln Gln Arg His  Lys Val Arg Glu Glu  Val Val Thr 
    2030                 2035                 2040             


Val Gly  Asn Ser Val Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp 
    2045                 2050                 2055             


Ser Cys  Phe Asp Pro Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp 
    2060                 2065                 2070             


Glu Trp  Glu Arg Met Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln 
    2075                 2080                 2085             


Cys Leu  Gly Phe Gly Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg 
    2090                 2095                 2100             


Trp Cys  His Asp Asn Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp 
    2105                 2110                 2115             


Asp Arg  Gln Gly Glu Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu 
    2120                 2125                 2130             


Gly Asn  Gly Lys Gly Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr 
    2135                 2140                 2145             


Cys Tyr  Asp Asp Gly Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln 
    2150                 2155                 2160             


Lys Glu  Tyr Leu Gly Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly 
    2165                 2170                 2175             


Gln Arg  Gly Trp Arg Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu 
    2180                 2185                 2190             


Pro Ser  Pro Glu Gly Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser 
    2195                 2200                 2205             


Gln Arg  Tyr His Gln Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile 
    2210                 2215                 2220             


Glu Cys  Phe Met Pro Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser 
    2225                 2230                 2235             


Arg Glu  
    2240 


<210>  83
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  84
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Trp Gln Gly Lys Tyr Lys Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Gln Phe Leu Glu Arg Leu Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Gly Gln Val Asp Thr Val Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  85
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  86
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  87
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  88
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Gly Asp Val Leu Glu Gln Phe Phe Ile Leu Thr Gly Leu Leu Val 
1               5                   10                  15      


Cys Leu Ala Cys Leu Ala Lys Cys Val Arg Phe Ser Arg Cys Val Leu 
            20                  25                  30          


Leu Asn Tyr Trp Lys Val Leu Pro Lys Ser Phe Leu Arg Ser Met Gly 
        35                  40                  45              


Gln Trp Ala Val Ile Thr Gly Ala Gly Asp Gly Ile Gly Lys Ala Tyr 
    50                  55                  60                  


Ser Phe Glu Leu Ala Lys Arg Gly Leu Asn Val Val Leu Ile Ser Arg 
65                  70                  75                  80  


Thr Leu Glu Lys Leu Glu Ala Ile Ala Thr Glu Ile Glu Arg Thr Thr 
                85                  90                  95      


Gly Arg Ser Val Lys Ile Ile Gln Ala Asp Phe Thr Lys Asp Asp Ile 
            100                 105                 110         


Tyr Glu His Ile Lys Glu Lys Leu Ala Gly Leu Glu Ile Gly Ile Leu 
        115                 120                 125             


Val Asn Asn Val Gly Met Leu Pro Asn Leu Leu Pro Ser His Phe Leu 
    130                 135                 140                 


Asn Ala Pro Asp Glu Ile Gln Ser Leu Ile His Cys Asn Ile Thr Ser 
145                 150                 155                 160 


Val Val Lys Met Thr Gln Leu Ile Leu Lys His Met Glu Ser Arg Gln 
                165                 170                 175     


Lys Gly Leu Ile Leu Asn Ile Ser Ser Gly Ile Ala Leu Phe Pro Trp 
            180                 185                 190         


Pro Leu Tyr Ser Met Tyr Ser Ala Ser Lys Ala Phe Val Cys Ala Phe 
        195                 200                 205             


Ser Lys Ala Leu Gln Glu Glu Tyr Lys Ala Lys Glu Val Ile Ile Gln 
    210                 215                 220                 


Val Leu Thr Pro Tyr Ala Val Ser Thr Ala Met Thr Lys Tyr Leu Asn 
225                 230                 235                 240 


Thr Asn Val Ile Thr Lys Thr Ala Asp Glu Phe Val Lys Glu Ser Leu 
                245                 250                 255     


Asn Tyr Val Thr Ile Gly Gly Glu Thr Cys Gly Cys Leu Ala His Glu 
            260                 265                 270         


Ile Leu Ala Gly Phe Leu Ser Leu Ile Pro Ala Trp Ala Phe Tyr Ser 
        275                 280                 285             


Gly Ala Phe Gln Arg Leu Leu Leu Thr His Tyr Val Ala Tyr Leu Lys 
    290                 295                 300                 


Leu Asn Thr Lys Val Arg 
305                 310 


<210>  89
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn Lys Tyr 
    210                 215                 220                 


Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met Ala Val 
                245                 250                 255     


Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu Val Val 
            260                 265                 270         


Lys Leu Phe Ser Glu Val Glu Asn Lys Asn Val Pro Leu Pro Glu Phe 
        275                 280                 285             


Pro Glu His Pro Phe Gln Glu Glu His Leu Lys Gln Leu Tyr Lys Ile 
    290                 295                 300                 


Val Pro Ile Lys Asp Ile Arg Asn Leu Tyr Val Thr Phe Pro Ile Pro 
305                 310                 315                 320 


Asp Leu Gln Lys Tyr Tyr Lys Ser Asn Pro Gly His Tyr Leu Gly His 
                325                 330                 335     


Leu Ile Gly His Glu Gly Pro Gly Ser Leu Leu Ser Glu Leu Lys Ser 
            340                 345                 350         


Lys Gly Trp Val Asn Thr Leu Val Gly Gly Gln Lys Glu Gly Ala Arg 
        355                 360                 365             


Gly Phe Met Phe Phe Ile Ile Asn Val Asp Leu Thr Glu Glu Gly Leu 
    370                 375                 380                 


Leu His Val Glu Asp Ile Ile Leu His Met Phe Gln Tyr Ile Gln Lys 
385                 390                 395                 400 


Leu Arg Ala Glu Gly Pro Gln Glu Trp Val Phe Gln Glu Cys Lys Asp 
                405                 410                 415     


Leu Asn Ala Val Ala Phe Arg Phe Lys Asp Lys Glu Arg Pro Arg Gly 
            420                 425                 430         


Tyr Thr Ser Lys Ile Ala Gly Ile Leu His Tyr Tyr Pro Leu Glu Glu 
        435                 440                 445             


Val Leu Thr Ala Glu Tyr Leu Leu Glu Glu Phe Arg Pro Asp Leu Ile 
    450                 455                 460                 


Glu Met Val Leu Asp Lys Leu Arg Pro Glu Asn Val Arg Val Ala Ile 
465                 470                 475                 480 


Val Ser Lys Ser Phe Glu Gly Lys Thr Asp Arg Thr Glu Glu Trp Tyr 
                485                 490                 495     


Gly Thr Gln Tyr Lys Gln Glu Ala Ile Pro Asp Glu Val Ile Lys Lys 
            500                 505                 510         


Trp Gln Asn Ala Asp Leu Asn Gly Lys Phe Lys Leu Pro Thr Lys Asn 
        515                 520                 525             


Glu Phe Ile Pro Thr Asn Phe Glu Ile Leu Pro Leu Glu Lys Glu Ala 
    530                 535                 540                 


Thr Pro Tyr Pro Ala Leu Ile Lys Asp Thr Ala Met Ser Lys Leu Trp 
545                 550                 555                 560 


Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys Ala Cys Leu Asn Phe 
                565                 570                 575     


Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro Leu His Cys Asn Met 
            580                 585                 590         


Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser Leu Asn Glu Tyr Ala 
        595                 600                 605             


Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp Leu Gln Asn Thr Ile 
    610                 615                 620                 


Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn Asp Lys Gln Pro Ile 
625                 630                 635                 640 


Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr Phe Glu Ile Asp Glu 
                645                 650                 655     


Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met Arg Ser Leu Asn Asn 
            660                 665                 670         


Phe Arg Ala Glu Gln Pro His Gln His Ala Met Tyr Tyr Leu Arg Leu 
        675                 680                 685             


Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu Leu Lys Glu Ala Leu 
    690                 695                 700                 


Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe Ile Pro Gln Leu Leu 
705                 710                 715                 720 


Ser Arg Leu His Ile Glu Ala Leu Leu His Gly Asn Ile Thr Lys Gln 
                725                 730                 735     


Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp Thr Leu Ile Glu His 
            740                 745                 750         


Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu Val Arg Tyr Arg Glu 
        755                 760                 765             


Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr Gln Gln Arg Asn Glu 
    770                 775                 780                 


Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr Gln Thr Asp Met Gln 
785                 790                 795                 800 


Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe Cys Gln Ile Ile Ser 
                805                 810                 815     


Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu Gln Leu Gly Tyr Ile 
            820                 825                 830         


Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile Gln Gly Leu Arg Phe 
        835                 840                 845             


Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu Glu Ser Arg Val Glu 
    850                 855                 860                 


Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu Asp Met Thr Glu Glu 
865                 870                 875                 880 


Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile Arg Arg Leu Asp Lys 
                885                 890                 895     


Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr Trp Gly Glu Ile Ile 
            900                 905                 910         


Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr Glu Val Ala Tyr Leu 
        915                 920                 925             


Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe Tyr Lys Glu Met Leu 
    930                 935                 940                 


Ala Val Asp Ala Pro Arg Arg His Lys Val Ser Val His Val Leu Ala 
945                 950                 955                 960 


Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu Phe Pro Cys Gln Asn 
                965                 970                 975     


Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro Gln Pro Glu Val Ile 
            980                 985                 990         


Gln Asn Met Thr Glu Phe Lys Arg  Gly Leu Pro Leu Phe  Pro Leu Val 
        995                 1000                 1005             


Lys Pro  His Ile Asn Phe Met  Ala Ala Lys Leu 
    1010                 1015                 


<210>  90
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys 
1               5                   10                  15      


Ala Cys Leu Asn Phe Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro 
            20                  25                  30          


Leu His Cys Asn Met Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser 
        35                  40                  45              


Leu Asn Glu Tyr Ala Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp 
    50                  55                  60                  


Leu Gln Asn Thr Ile Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn 
65                  70                  75                  80  


Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr 
                85                  90                  95      


Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met 
            100                 105                 110         


Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His Gln His Ala Met 
        115                 120                 125             


Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu 
    130                 135                 140                 


Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe 
145                 150                 155                 160 


Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala Leu Leu His Gly 
                165                 170                 175     


Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp 
            180                 185                 190         


Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu 
        195                 200                 205             


Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr 
    210                 215                 220                 


Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr 
225                 230                 235                 240 


Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe 
                245                 250                 255     


Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu 
            260                 265                 270         


Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile 
        275                 280                 285             


Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu 
    290                 295                 300                 


Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu 
305                 310                 315                 320 


Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile 
                325                 330                 335     


Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr 
            340                 345                 350         


Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr 
        355                 360                 365             


Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe 
    370                 375                 380                 


Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg His Lys Val Ser 
385                 390                 395                 400 


Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu 
                405                 410                 415     


Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro 
            420                 425                 430         


Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys Arg Gly Leu Pro 
        435                 440                 445             


Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met Ala Ala Lys Leu 
    450                 455                 460                 


<210>  91
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Asn Lys Tyr 
    210                 215                 220                 


Thr Leu Glu Thr Arg Pro Asn Gln Glu Gly Ile Asp Val Arg Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Phe His Ser Ala Tyr Tyr Ser Ser Asn Leu Met Ala Val 
                245                 250                 255     


Cys Val Leu Gly Arg Glu Ser Leu Asp Asp Leu Thr Asn Leu Val Val 
            260                 265                 270         


Lys Leu Phe Ser Glu Val Glu Asn Lys Asn Val Pro Leu Pro Glu Phe 
        275                 280                 285             


Pro Glu His Pro Phe Gln Glu Glu His Leu Lys Gln Leu Tyr Lys Ile 
    290                 295                 300                 


Val Pro Ile Lys Asp Ile Arg Asn Leu Tyr Val Thr Phe Pro Ile Pro 
305                 310                 315                 320 


Asp Leu Gln Lys Tyr Tyr Lys Ser Asn Pro Gly His Tyr Leu Gly His 
                325                 330                 335     


Leu Ile Gly His Glu Gly Pro Gly Ser Leu Leu Ser Glu Leu Lys Ser 
            340                 345                 350         


Lys Gly Trp Val Asn Thr Leu Val Gly Gly Gln Lys Glu Gly Ala Arg 
        355                 360                 365             


Gly Phe Met Phe Phe Ile Ile Asn Val Asp Leu Thr Glu Glu Gly Leu 
    370                 375                 380                 


Leu His Val Glu Asp Ile Ile Leu His Met Phe Gln Tyr Ile Gln Lys 
385                 390                 395                 400 


Leu Arg Ala Glu Gly Pro Gln Glu Trp Val Phe Gln Glu Cys Lys Asp 
                405                 410                 415     


Leu Asn Ala Val Ala Phe Arg Phe Lys Asp Lys Glu Arg Pro Arg Gly 
            420                 425                 430         


Tyr Thr Ser Lys Ile Ala Gly Ile Leu His Tyr Tyr Pro Leu Glu Glu 
        435                 440                 445             


Val Leu Thr Ala Glu Tyr Leu Leu Glu Glu Phe Arg Pro Asp Leu Ile 
    450                 455                 460                 


Glu Met Val Leu Asp Lys Leu Arg Pro Glu Asn Val Arg Val Ala Ile 
465                 470                 475                 480 


Val Ser Lys Ser Phe Glu Gly Lys Thr Asp Arg Thr Glu Glu Trp Tyr 
                485                 490                 495     


Gly Thr Gln Tyr Lys Gln Glu Ala Ile Pro Asp Glu Val Ile Lys Lys 
            500                 505                 510         


Trp Gln Asn Ala Asp Leu Asn Gly Lys Phe Lys Leu Pro Thr Lys Asn 
        515                 520                 525             


Glu Phe Ile Pro Thr Asn Phe Glu Ile Leu Pro Leu Glu Lys Glu Ala 
    530                 535                 540                 


Thr Pro Tyr Pro Ala Leu Ile Lys Asp Thr Ala Met Ser Lys Leu Trp 
545                 550                 555                 560 


Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys Ala Cys Leu Asn Phe 
                565                 570                 575     


Glu Phe Phe Ser Arg Tyr Ile Tyr Ala Asp Pro Leu His Cys Asn Met 
            580                 585                 590         


Thr Tyr Leu Phe Ile Arg Leu Leu Lys Asp Asp Leu Lys Glu Tyr Thr 
        595                 600                 605             


Tyr Ala Ala Arg Leu Ser Gly Leu Ser Tyr Gly Ile Ala Ser Gly Met 
    610                 615                 620                 


Asn Ala Ile Leu Leu Ser Val Lys Gly Tyr Asn Asp Lys Gln Pro Ile 
625                 630                 635                 640 


Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr Phe Glu Ile Asp Glu 
                645                 650                 655     


Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met Arg Ser Leu Asn Asn 
            660                 665                 670         


Phe Arg Ala Glu Gln Pro His Gln His Ala Met Tyr Tyr Leu Arg Leu 
        675                 680                 685             


Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu Leu Lys Glu Ala Leu 
    690                 695                 700                 


Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe Ile Pro Gln Leu Leu 
705                 710                 715                 720 


Ser Arg Leu His Ile Glu Ala Leu Leu His Gly Asn Ile Thr Lys Gln 
                725                 730                 735     


Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp Thr Leu Ile Glu His 
            740                 745                 750         


Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu Val Arg Tyr Arg Glu 
        755                 760                 765             


Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr Gln Gln Arg Asn Glu 
    770                 775                 780                 


Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr Gln Thr Asp Met Gln 
785                 790                 795                 800 


Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe Cys Gln Ile Ile Ser 
                805                 810                 815     


Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu Gln Leu Gly Tyr Ile 
            820                 825                 830         


Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile Gln Gly Leu Arg Phe 
        835                 840                 845             


Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu Glu Ser Arg Val Glu 
    850                 855                 860                 


Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu Asp Met Thr Glu Glu 
865                 870                 875                 880 


Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile Arg Arg Leu Asp Lys 
                885                 890                 895     


Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr Trp Gly Glu Ile Ile 
            900                 905                 910         


Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr Glu Val Ala Tyr Leu 
        915                 920                 925             


Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe Tyr Lys Glu Met Leu 
    930                 935                 940                 


Ala Val Asp Ala Pro Arg Arg His Lys Val Ser Val His Val Leu Ala 
945                 950                 955                 960 


Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu Phe Pro Cys Gln Asn 
                965                 970                 975     


Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro Gln Pro Glu Val Ile 
            980                 985                 990         


Gln Asn Met Thr Glu Phe Lys Arg  Gly Leu Pro Leu Phe  Pro Leu Val 
        995                 1000                 1005             


Lys Pro  His Ile Asn Phe Met  Ala Ala Lys Leu 
    1010                 1015                 


<210>  92
<211>  980
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Arg Tyr Arg Leu Ala Trp Leu Leu His Pro Ala Leu Pro Ser Thr 
1               5                   10                  15      


Phe Arg Ser Val Leu Gly Ala Arg Leu Pro Pro Pro Glu Arg Leu Cys 
            20                  25                  30          


Gly Phe Gln Lys Lys Thr Tyr Ser Lys Met Asn Asn Pro Ala Ile Lys 
        35                  40                  45              


Arg Ile Gly Asn His Ile Thr Lys Ser Pro Glu Asp Lys Arg Glu Tyr 
    50                  55                  60                  


Arg Gly Leu Glu Leu Ala Asn Gly Ile Lys Val Leu Leu Ile Ser Asp 
65                  70                  75                  80  


Pro Thr Thr Asp Lys Ser Ser Ala Ala Leu Asp Val His Ile Gly Ser 
                85                  90                  95      


Leu Ser Asp Pro Pro Asn Ile Ala Gly Leu Ser His Phe Cys Glu His 
            100                 105                 110         


Met Leu Phe Leu Gly Thr Lys Lys Tyr Pro Lys Glu Asn Glu Tyr Ser 
        115                 120                 125             


Gln Phe Leu Ser Glu His Ala Gly Ser Ser Asn Ala Phe Thr Ser Gly 
    130                 135                 140                 


Glu His Thr Asn Tyr Tyr Phe Asp Val Ser His Glu His Leu Glu Gly 
145                 150                 155                 160 


Ala Leu Asp Arg Phe Ala Gln Phe Phe Leu Cys Pro Leu Phe Asp Glu 
                165                 170                 175     


Ser Cys Lys Asp Arg Glu Val Asn Ala Val Asp Ser Glu His Glu Lys 
            180                 185                 190         


Asn Val Met Asn Asp Ala Trp Arg Leu Phe Gln Leu Glu Lys Ala Thr 
        195                 200                 205             


Gly Asn Pro Lys His Pro Phe Ser Lys Phe Gly Thr Gly Arg Glu Ser 
    210                 215                 220                 


Leu Asp Asp Leu Thr Asn Leu Val Val Lys Leu Phe Ser Glu Val Glu 
225                 230                 235                 240 


Asn Lys Asn Val Pro Leu Pro Glu Phe Pro Glu His Pro Phe Gln Glu 
                245                 250                 255     


Glu His Leu Lys Gln Leu Tyr Lys Ile Val Pro Ile Lys Asp Ile Arg 
            260                 265                 270         


Asn Leu Tyr Val Thr Phe Pro Ile Pro Asp Leu Gln Lys Tyr Tyr Lys 
        275                 280                 285             


Ser Asn Pro Gly His Tyr Leu Gly His Leu Ile Gly His Glu Gly Pro 
    290                 295                 300                 


Gly Ser Leu Leu Ser Glu Leu Lys Ser Lys Gly Trp Val Asn Thr Leu 
305                 310                 315                 320 


Val Gly Gly Gln Lys Glu Gly Ala Arg Gly Phe Met Phe Phe Ile Ile 
                325                 330                 335     


Asn Val Asp Leu Thr Glu Glu Gly Leu Leu His Val Glu Asp Ile Ile 
            340                 345                 350         


Leu His Met Phe Gln Tyr Ile Gln Lys Leu Arg Ala Glu Gly Pro Gln 
        355                 360                 365             


Glu Trp Val Phe Gln Glu Cys Lys Asp Leu Asn Ala Val Ala Phe Arg 
    370                 375                 380                 


Phe Lys Asp Lys Glu Arg Pro Arg Gly Tyr Thr Ser Lys Ile Ala Gly 
385                 390                 395                 400 


Ile Leu His Tyr Tyr Pro Leu Glu Glu Val Leu Thr Ala Glu Tyr Leu 
                405                 410                 415     


Leu Glu Glu Phe Arg Pro Asp Leu Ile Glu Met Val Leu Asp Lys Leu 
            420                 425                 430         


Arg Pro Glu Asn Val Arg Val Ala Ile Val Ser Lys Ser Phe Glu Gly 
        435                 440                 445             


Lys Thr Asp Arg Thr Glu Glu Trp Tyr Gly Thr Gln Tyr Lys Gln Glu 
    450                 455                 460                 


Ala Ile Pro Asp Glu Val Ile Lys Lys Trp Gln Asn Ala Asp Leu Asn 
465                 470                 475                 480 


Gly Lys Phe Lys Leu Pro Thr Lys Asn Glu Phe Ile Pro Thr Asn Phe 
                485                 490                 495     


Glu Ile Leu Pro Leu Glu Lys Glu Ala Thr Pro Tyr Pro Ala Leu Ile 
            500                 505                 510         


Lys Asp Thr Ala Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe 
        515                 520                 525             


Phe Leu Pro Lys Ala Cys Leu Asn Phe Glu Phe Phe Ser Pro Phe Ala 
    530                 535                 540                 


Tyr Val Asp Pro Leu His Cys Asn Met Ala Tyr Leu Tyr Leu Glu Leu 
545                 550                 555                 560 


Leu Lys Asp Ser Leu Asn Glu Tyr Ala Tyr Ala Ala Glu Leu Ala Gly 
                565                 570                 575     


Leu Ser Tyr Asp Leu Gln Asn Thr Ile Tyr Gly Met Tyr Leu Ser Val 
            580                 585                 590         


Lys Gly Tyr Asn Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu 
        595                 600                 605             


Lys Met Ala Thr Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys 
    610                 615                 620                 


Glu Ala Tyr Met Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His 
625                 630                 635                 640 


Gln His Ala Met Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp 
                645                 650                 655     


Thr Lys Asp Glu Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg 
            660                 665                 670         


Leu Lys Ala Phe Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala 
        675                 680                 685             


Leu Leu His Gly Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln 
    690                 695                 700                 


Met Val Glu Asp Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu 
705                 710                 715                 720 


Pro Ser Gln Leu Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly 
                725                 730                 735     


Trp Phe Val Tyr Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile 
            740                 745                 750         


Glu Ile Tyr Tyr Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe 
        755                 760                 765             


Leu Glu Leu Phe Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu 
    770                 775                 780                 


Arg Thr Lys Glu Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg 
785                 790                 795                 800 


Ala Asn Gly Ile Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro 
                805                 810                 815     


Pro His Tyr Leu Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu 
            820                 825                 830         


Lys Ser Ile Glu Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln 
        835                 840                 845             


Ala Leu Ala Ile Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu 
    850                 855                 860                 


Cys Ala Lys Tyr Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp 
865                 870                 875                 880 


Arg Asp Asn Thr Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp 
                885                 890                 895     


Ile Ile Lys Phe Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg 
            900                 905                 910         


His Lys Val Ser Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro 
        915                 920                 925             


Val Val Gly Glu Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala 
    930                 935                 940                 


Pro Ala Leu Pro Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys 
945                 950                 955                 960 


Arg Gly Leu Pro Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met 
                965                 970                 975     


Ala Ala Lys Leu 
            980 


<210>  93
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Asn Asn Pro Ala Ile Lys Arg Ile Gly Asn His Ile Thr Lys Ser 
1               5                   10                  15      


Pro Glu Asp Lys Arg Glu Tyr Arg Gly Leu Glu Leu Ala Asn Gly Ile 
            20                  25                  30          


Lys Val Leu Leu Ile Ser Asp Pro Thr Thr Asp Lys Ser Ser Ala Ala 
        35                  40                  45              


Leu Asp Val His Ile Gly Ser Leu Ser Asp Pro Pro Asn Ile Ala Gly 
    50                  55                  60                  


Leu Ser His Phe Cys Glu His Met Leu Phe Leu Gly Thr Lys Lys Tyr 
65                  70                  75                  80  


Pro Lys Glu Asn Glu Tyr Ser Gln Phe Leu Ser Glu His Ala Gly Ser 
                85                  90                  95      


Ser Asn Ala Phe Thr Ser Gly Glu His Thr Asn Tyr Tyr Phe Asp Val 
            100                 105                 110         


Ser His Glu His Leu Glu Gly Ala Leu Asp Arg Phe Ala Gln Phe Phe 
        115                 120                 125             


Leu Cys Pro Leu Phe Asp Glu Ser Cys Lys Asp Arg Glu Val Asn Ala 
    130                 135                 140                 


Val Asp Ser Glu His Glu Lys Asn Val Met Asn Asp Ala Trp Arg Leu 
145                 150                 155                 160 


Phe Gln Leu Glu Lys Ala Thr Gly Asn Pro Lys His Pro Phe Ser Lys 
                165                 170                 175     


Phe Gly Thr Gly Asn Lys Tyr Thr Leu Glu Thr Arg Pro Asn Gln Glu 
            180                 185                 190         


Gly Ile Asp Val Arg Gln Glu Leu Leu Lys Phe His Ser Ala Tyr Tyr 
        195                 200                 205             


Ser Ser Asn Leu Met Ala Val Cys Val Leu Gly Arg Glu Ser Leu Asp 
    210                 215                 220                 


Asp Leu Thr Asn Leu Val Val Lys Leu Phe Ser Glu Val Glu Asn Lys 
225                 230                 235                 240 


Asn Val Pro Leu Pro Glu Phe Pro Glu His Pro Phe Gln Glu Glu His 
                245                 250                 255     


Leu Lys Gln Leu Tyr Lys Ile Val Pro Ile Lys Asp Ile Arg Asn Leu 
            260                 265                 270         


Tyr Val Thr Phe Pro Ile Pro Asp Leu Gln Lys Tyr Tyr Lys Ser Asn 
        275                 280                 285             


Pro Gly His Tyr Leu Gly His Leu Ile Gly His Glu Gly Pro Gly Ser 
    290                 295                 300                 


Leu Leu Ser Glu Leu Lys Ser Lys Gly Trp Val Asn Thr Leu Val Gly 
305                 310                 315                 320 


Gly Gln Lys Glu Gly Ala Arg Gly Phe Met Phe Phe Ile Ile Asn Val 
                325                 330                 335     


Asp Leu Thr Glu Glu Gly Leu Leu His Val Glu Asp Ile Ile Leu His 
            340                 345                 350         


Met Phe Gln Tyr Ile Gln Lys Leu Arg Ala Glu Gly Pro Gln Glu Trp 
        355                 360                 365             


Val Phe Gln Glu Cys Lys Asp Leu Asn Ala Val Ala Phe Arg Phe Lys 
    370                 375                 380                 


Asp Lys Glu Arg Pro Arg Gly Tyr Thr Ser Lys Ile Ala Gly Ile Leu 
385                 390                 395                 400 


His Tyr Tyr Pro Leu Glu Glu Val Leu Thr Ala Glu Tyr Leu Leu Glu 
                405                 410                 415     


Glu Phe Arg Pro Asp Leu Ile Glu Met Val Leu Asp Lys Leu Arg Pro 
            420                 425                 430         


Glu Asn Val Arg Val Ala Ile Val Ser Lys Ser Phe Glu Gly Lys Thr 
        435                 440                 445             


Asp Arg Thr Glu Glu Trp Tyr Gly Thr Gln Tyr Lys Gln Glu Ala Ile 
    450                 455                 460                 


Pro Asp Glu Val Ile Lys Lys Trp Gln Asn Ala Asp Leu Asn Gly Lys 
465                 470                 475                 480 


Phe Lys Leu Pro Thr Lys Asn Glu Phe Ile Pro Thr Asn Phe Glu Ile 
                485                 490                 495     


Leu Pro Leu Glu Lys Glu Ala Thr Pro Tyr Pro Ala Leu Ile Lys Asp 
            500                 505                 510         


Thr Ala Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe Phe Leu 
        515                 520                 525             


Pro Lys Ala Cys Leu Asn Phe Glu Phe Phe Ser Pro Phe Ala Tyr Val 
    530                 535                 540                 


Asp Pro Leu His Cys Asn Met Ala Tyr Leu Tyr Leu Glu Leu Leu Lys 
545                 550                 555                 560 


Asp Ser Leu Asn Glu Tyr Ala Tyr Ala Ala Glu Leu Ala Gly Leu Ser 
                565                 570                 575     


Tyr Asp Leu Gln Asn Thr Ile Tyr Gly Met Tyr Leu Ser Val Lys Gly 
            580                 585                 590         


Tyr Asn Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu Lys Met 
        595                 600                 605             


Ala Thr Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys Glu Ala 
    610                 615                 620                 


Tyr Met Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His Gln His 
625                 630                 635                 640 


Ala Met Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp Thr Lys 
                645                 650                 655     


Asp Glu Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg Leu Lys 
            660                 665                 670         


Ala Phe Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala Leu Leu 
        675                 680                 685             


His Gly Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln Met Val 
    690                 695                 700                 


Glu Asp Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu Pro Ser 
705                 710                 715                 720 


Gln Leu Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly Trp Phe 
                725                 730                 735     


Val Tyr Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile Glu Ile 
            740                 745                 750         


Tyr Tyr Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe Leu Glu 
        755                 760                 765             


Leu Phe Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu Arg Thr 
    770                 775                 780                 


Lys Glu Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg Ala Asn 
785                 790                 795                 800 


Gly Ile Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro Pro His 
                805                 810                 815     


Tyr Leu Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu Lys Ser 
            820                 825                 830         


Ile Glu Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln Ala Leu 
        835                 840                 845             


Ala Ile Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu Cys Ala 
    850                 855                 860                 


Lys Tyr Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp Arg Asp 
865                 870                 875                 880 


Asn Thr Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp Ile Ile 
                885                 890                 895     


Lys Phe Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg His Lys 
            900                 905                 910         


Val Ser Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro Val Val 
        915                 920                 925             


Gly Glu Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala Pro Ala 
    930                 935                 940                 


Leu Pro Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys Arg Gly 
945                 950                 955                 960 


Leu Pro Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met Ala Ala 
                965                 970                 975     


Lys Leu 
        


<210>  94
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys 
1               5                   10                  15      


Ala Cys Leu Asn Phe Glu Phe Phe Ser Arg Tyr Ile Tyr Ala Asp Pro 
            20                  25                  30          


Leu His Cys Asn Met Thr Tyr Leu Phe Ile Arg Leu Leu Lys Asp Asp 
        35                  40                  45              


Leu Lys Glu Tyr Thr Tyr Ala Ala Arg Leu Ser Gly Leu Ser Tyr Gly 
    50                  55                  60                  


Ile Ala Ser Gly Met Asn Ala Ile Leu Leu Ser Val Lys Gly Tyr Asn 
65                  70                  75                  80  


Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr 
                85                  90                  95      


Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met 
            100                 105                 110         


Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His Gln His Ala Met 
        115                 120                 125             


Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu 
    130                 135                 140                 


Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe 
145                 150                 155                 160 


Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala Leu Leu His Gly 
                165                 170                 175     


Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp 
            180                 185                 190         


Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu 
        195                 200                 205             


Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr 
    210                 215                 220                 


Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr 
225                 230                 235                 240 


Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe 
                245                 250                 255     


Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu 
            260                 265                 270         


Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile 
        275                 280                 285             


Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu 
    290                 295                 300                 


Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu 
305                 310                 315                 320 


Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile 
                325                 330                 335     


Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr 
            340                 345                 350         


Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr 
        355                 360                 365             


Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe 
    370                 375                 380                 


Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg His Lys Val Ser 
385                 390                 395                 400 


Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu 
                405                 410                 415     


Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro 
            420                 425                 430         


Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys Arg Gly Leu Pro 
        435                 440                 445             


Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met Ala Ala Lys Leu 
    450                 455                 460                 


<210>  95
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala His Ala Met Glu Asn Ser Trp Thr Ile Ser Lys Glu Tyr His 
1               5                   10                  15      


Ile Asp Glu Glu Val Gly Phe Ala Leu Pro Asn Pro Gln Glu Asn Leu 
            20                  25                  30          


Pro Asp Phe Tyr Asn Asp Trp Met Phe Ile Ala Lys His Leu Pro Asp 
        35                  40                  45              


Leu Ile Glu Ser Gly Gln Leu Arg Glu Arg Val Glu Lys Leu Asn Met 
    50                  55                  60                  


Leu Ser Ile Asp His Leu Thr Asp His Lys Ser Gln Arg Leu Ala Arg 
65                  70                  75                  80  


Leu Val Leu Gly Cys Ile Thr Met Ala Tyr Val Trp Gly Lys Gly His 
                85                  90                  95      


Gly Asp Val Arg Lys Val Leu Pro Arg Asn Ile Ala Val Pro Tyr Cys 
            100                 105                 110         


Gln Leu Ser Lys Lys Leu Glu Leu Pro Pro Ile Leu Val Tyr Ala Asp 
        115                 120                 125             


Cys Val Leu Ala Asn Trp Lys Lys Lys Asp Pro Asn Lys Pro Leu Thr 
    130                 135                 140                 


Tyr Glu Asn Met Asp Val Leu Phe Ser Phe Arg Asp Gly Asp Cys Ser 
145                 150                 155                 160 


Lys Gly Phe Phe Leu Val Ser Leu Leu Val Glu Ile Ala Ala Ala Ser 
                165                 170                 175     


Ala Ile Lys Val Ile Pro Thr Val Phe Lys Ala Met Gln Met Gln Glu 
            180                 185                 190         


Arg Asp Thr Leu Leu Lys Ala Leu Leu Glu Ile Ala Ser Cys Leu Glu 
        195                 200                 205             


Lys Ala Leu Gln Val Phe His Gln Ile His Asp His Val Asn Pro Lys 
    210                 215                 220                 


Ala Phe Phe Ser Val Leu Arg Ile Tyr Leu Ser Gly Trp Lys Gly Asn 
225                 230                 235                 240 


Pro Gln Leu Ser Asp Gly Leu Val Tyr Glu Gly Phe Trp Glu Asp Pro 
                245                 250                 255     


Lys Glu Phe Ala Gly Gly Ser Ala Gly Gln Ser Ser Val Phe Gln Cys 
            260                 265                 270         


Phe Asp Val Leu Leu Gly Ile Gln Gln Thr Ala Gly Gly Gly His Ala 
        275                 280                 285             


Ala Gln Phe Leu Gln Asp Met Arg Arg Tyr Met Pro Pro Ala His Arg 
    290                 295                 300                 


Asn Phe Leu Cys Ser Leu Glu Ser Asn Pro Ser Val Arg Glu Phe Val 
305                 310                 315                 320 


Leu Ser Lys Gly Asp Ala Gly Leu Arg Glu Ala Tyr Asp Ala Cys Val 
                325                 330                 335     


Lys Ala Leu Val Ser Leu Arg Ser Tyr His Leu Gln Ile Val Thr Lys 
            340                 345                 350         


Tyr Ile Leu Ile Pro Ala Ser Gln Gln Pro Lys Glu Asn Lys Thr Ser 
        355                 360                 365             


Glu Asp Pro Ser Lys Leu Glu Ala Lys Gly Thr Gly Gly Thr Asp Leu 
    370                 375                 380                 


Met Asn Phe Leu Lys Thr Val Arg Ser Thr Thr Glu Lys Ser Leu Leu 
385                 390                 395                 400 


Lys Glu Gly 
            


<210>  96
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  97
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210>  98
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Thr Gln 
        275                 


<210>  99
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Leu Gln Ser Leu Ala Gly Ser Ser Cys Val Arg Leu Val Glu Arg 
1               5                   10                  15      


His Arg Ser Ala Trp Cys Phe Gly Phe Leu Val Leu Gly Tyr Leu Leu 
            20                  25                  30          


Tyr Leu Val Phe Gly Ala Val Val Phe Ser Ser Val Glu Leu Pro Tyr 
        35                  40                  45              


Glu Asp Leu Leu Arg Gln Glu Leu Arg Lys Leu Lys Arg Arg Phe Leu 
    50                  55                  60                  


Glu Glu His Glu Cys Leu Ser Glu Gln Gln Leu Glu Gln Phe Leu Gly 
65                  70                  75                  80  


Arg Val Leu Glu Ala Ser Asn Tyr Gly Val Ser Val Leu Ser Asn Ala 
                85                  90                  95      


Ser Gly Asn Trp Asn Trp Asp Phe Thr Ser Ala Leu Phe Phe Ala Ser 
            100                 105                 110         


Thr Val Leu Ser Thr Thr Gly Tyr Gly His Thr Val Pro Leu Ser Asp 
        115                 120                 125             


Gly Gly Lys Ala Phe Cys Ile Ile Tyr Ser Val Ile Gly Ile Pro Phe 
    130                 135                 140                 


Thr Leu Leu Phe Leu Thr Ala Val Val Gln Arg Ile Thr Val His Val 
145                 150                 155                 160 


Thr Arg Arg Pro Val Leu Tyr Phe His Ile Arg Trp Gly Phe Ser Lys 
                165                 170                 175     


Gln Val Val Ala Ile Val His Ala Val Leu Leu Gly Phe Val Thr Val 
            180                 185                 190         


Ser Cys Phe Phe Phe Ile Pro Ala Ala Val Phe Ser Val Leu Glu Asp 
        195                 200                 205             


Asp Trp Asn Phe Leu Glu Ser Phe Tyr Phe Cys Phe Ile Ser Leu Ser 
    210                 215                 220                 


Thr Ile Gly Leu Gly Asp Tyr Val Pro Gly Glu Gly Tyr Asn Gln Lys 
225                 230                 235                 240 


Phe Arg Glu Leu Tyr Lys Ile Gly Ile Thr Cys Tyr Leu Leu Leu Gly 
                245                 250                 255     


Leu Ile Ala Met Leu Val Val Leu Glu Thr Phe Cys Glu Leu His Glu 
            260                 265                 270         


Leu Lys Lys Phe Arg Lys Met Phe Tyr Val Lys Lys Asp Lys Asp Glu 
        275                 280                 285             


Asp Gln Val His Ile Ile Glu His Asp Gln Leu Ser Phe Ser Ser Ile 
    290                 295                 300                 


Thr Asp Gln Ala Ala Gly Met Lys Glu Asp Gln Lys Gln Asn Glu Pro 
305                 310                 315                 320 


Phe Val Ala Thr Gln Ser Ser Ala Cys Val Asp Gly Pro Ala Asn His 
                325                 330                 335     


<210>  100
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  101
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg 
1               5                   10                  15      


Lys Ala Arg Asp Glu Thr Arg Gly Leu Asn Val Pro Gln Val Thr Glu 
            20                  25                  30          


Ala Glu Glu Glu Glu Ala Pro Cys Cys Ser Ser Ser Val Ser Gly Gly 
        35                  40                  45              


Ala Ala Ser Ser Ser Pro Ala Ala Gly Ile Pro Gln Glu Pro Gln Arg 
    50                  55                  60                  


Ala Pro Thr Thr Ala Ala Ala Ala Ala Ala Gly Val Ser Ser Thr Lys 
65                  70                  75                  80  


Ser Lys Lys Gly Ala Lys Ser His Gln Gly Glu Lys Asn Ala Ser Ser 
                85                  90                  95      


Ser Gln Ala Ser Thr Ser Thr Lys Ser Pro Ser Glu Asp Pro Leu Thr 
            100                 105                 110         


Arg Lys Ser Gly Ser Leu Val Gln Phe Leu Leu Tyr Lys Tyr Lys Ile 
        115                 120                 125             


Lys Lys Ser Val Thr Lys Gly Glu Met Leu Lys Ile Val Gly Lys Arg 
    130                 135                 140                 


Phe Arg Glu His Phe Pro Glu Ile Leu Lys Lys Ala Ser Glu Gly Leu 
145                 150                 155                 160 


Ser Val Val Phe Gly Leu Glu Leu Asn Lys Val Asn Pro Asn Gly His 
                165                 170                 175     


Thr Tyr Thr Phe Ile Asp Lys Val Asp Leu Thr Asp Glu Glu Ser Leu 
            180                 185                 190         


Leu Ser Ser Trp Asp Phe Pro Arg Arg Lys Leu Leu Met Pro Leu Leu 
        195                 200                 205             


Gly Val Ile Phe Leu Asn Gly Asn Ser Ala Thr Glu Glu Glu Ile Trp 
    210                 215                 220                 


Glu Phe Leu Asn Met Leu Gly Val Tyr Asp Gly Glu Glu His Ser Val 
225                 230                 235                 240 


Phe Gly Glu Pro Trp Lys Leu Ile Thr Lys Asp Leu Val Gln Glu Lys 
                245                 250                 255     


Tyr Leu Glu Tyr Lys Gln Val Pro Ser Ser Asp Pro Pro Arg Phe Gln 
            260                 265                 270         


Phe Leu Trp Gly Pro Arg Ala Tyr Ala Glu Thr Ser Lys Met Lys Val 
        275                 280                 285             


Leu Glu Phe Leu Ala Lys Val Asn Gly Thr Thr Pro Cys Ala Phe Pro 
    290                 295                 300                 


Thr His Tyr Glu Glu Ala Leu Lys Asp Glu Glu Lys Ala Gly Val 
305                 310                 315                 


<210>  102
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  103
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Arg Asn Lys Lys Ile Leu Lys Glu Asp Glu Leu Leu Ser Glu Thr 
1               5                   10                  15      


Gln Gln Ala Ala Phe His Gln Ile Ala Met Glu Pro Phe Glu Ile Asn 
            20                  25                  30          


Val Pro Lys Pro Lys Arg Arg Asn Gly Val Asn Phe Ser Leu Ala Val 
        35                  40                  45              


Val Val Ile Tyr Leu Ile Leu Leu Thr Ala Gly Ala Gly Leu Leu Val 
    50                  55                  60                  


Val Gln Val Leu Asn Leu Gln Ala Arg Leu Arg Val Leu Glu Met Tyr 
65                  70                  75                  80  


Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu 
                85                  90                  95      


Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg 
            100                 105                 110         


Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu 
        115                 120                 125             


His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe 
    130                 135                 140                 


Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly 
145                 150                 155                 160 


Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu 
                165                 170                 175     


Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser 
            180                 185                 190         


Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly 
        195                 200                 205             


Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro 
    210                 215                 220                 


Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys 
225                 230                 235                 240 


Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly 
                245                 250                 255     


Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met Gly Pro 
            260                 265                 270         


Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro 
        275                 280                 285             


Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Gly Gln Pro Gly 
    290                 295                 300                 


Leu Gln Gly Val Pro Gly Pro Pro Gly Ala Val Gly His Pro Gly Ala 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ser Ala Gly Ser Pro Gly Arg Ala Gly Leu Pro 
                325                 330                 335     


Gly Ser Pro Gly Ser Pro Gly Ala Thr Gly Leu Lys Gly Ser Lys Gly 
            340                 345                 350         


Asp Thr Gly Leu Gln Gly Gln Gln Gly Arg Lys Gly Glu Ser Gly Val 
        355                 360                 365             


Pro Gly Pro Ala Gly Val Lys Gly Glu Gln Gly Ser Pro Gly Leu Ala 
    370                 375                 380                 


Gly Pro Lys Gly Ala Pro Gly Gln Ala Gly Gln Lys Gly Asp Gln Gly 
385                 390                 395                 400 


Val Lys Gly Ser Ser Gly Glu Gln Gly Val Lys Gly Glu Lys Gly Glu 
                405                 410                 415     


Arg Gly Glu Asn Ser Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg 
            420                 425                 430         


Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp 
        435                 440                 445             


Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly 
    450                 455                 460                 


Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln 
465                 470                 475                 480 


Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp 
                485                 490                 495     


Ser Cys Thr Lys Asn Ser Trp Gly His His Asp Cys Ser His Glu Glu 
            500                 505                 510         


Asp Ala Gly Val Glu Cys Ser Val 
        515                 520 


<210>  104
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr 
1               5                   10                  15      


Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu 
            20                  25                  30          


Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe 
        35                  40                  45              


Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His 
    50                  55                  60                  


Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp 
65                  70                  75                  80  


Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys 
                85                  90                  95      


Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln 
            100                 105                 110         


Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His 
        115                 120                 125             


Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val 
    130                 135                 140                 


Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly 
145                 150                 155                 160 


Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu 
                165                 170                 175     


Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile 
            180                 185                 190         


Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr 
        195                 200                 205             


Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe 
    210                 215                 220                 


Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys 
225                 230                 235                 240 


Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu 
                245                 250                 255     


Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly 
            260                 265                 270         


Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr 
        275                 280                 285             


Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu 
    290                 295                 300                 


Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu 
305                 310                 315                 320 


Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser 
                325                 330                 335     


Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu 
            340                 345                 350         


Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val 
        355                 360                 365             


Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly 
    370                 375                 380                 


Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg 
385                 390                 395                 400 


Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser 
                405                 410                 415     


Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser 
            420                 425                 430         


Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr 
        435                 440                 445             


Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly 
    450                 455                 460                 


Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr 
465                 470                 475                 480 


Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu 
                485                 490                 495     


Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys 
            500                 505                 510         


Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr 
        515                 520                 525             


Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met 
    530                 535                 540                 


Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro 
545                 550                 555                 560 


Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln 
                565                 570         


<210>  105
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Val Glu Ala Glu Glu Leu Ala Gln Leu Arg Leu Leu Asn Leu Glu 
1               5                   10                  15      


Leu Leu Arg Gln Leu Trp Val Gly Gln Asp Ala Val Arg Arg Ser Val 
            20                  25                  30          


Ala Arg Ala Ala Ser Glu Ser Ser Leu Glu Ser Ser Ser Ser Tyr Asn 
        35                  40                  45              


Ser Glu Thr Pro Ser Thr Pro Glu Thr Ser Ser Thr Ser Leu Ser Thr 
    50                  55                  60                  


Ser Cys Pro Arg Gly Arg Ser Ser Val Trp Gly Pro Pro Asp Ala Cys 
65                  70                  75                  80  


Arg Gly Asp Leu Arg Asp Val Ala Arg Ser Gly Val Ala Ser Leu Pro 
                85                  90                  95      


Pro Ala Lys Cys Gln His Gln Glu Ser Leu Gly Arg Pro Arg Pro His 
            100                 105                 110         


Ser Ala Pro Ser Leu Gly Thr Ser Ser Leu Arg Asp Pro Glu Pro Ser 
        115                 120                 125             


Gly Arg Leu Gly Asp Pro Gly Pro Gln Glu Ala Gln Thr Pro Arg Ser 
    130                 135                 140                 


Ile Leu Ala Gln Gln Ser Lys Leu Ser Lys Pro Arg Val Thr Phe Ser 
145                 150                 155                 160 


Glu Glu Ser Ala Val Pro Lys Arg Ser Trp Arg Leu Arg Pro Tyr Leu 
                165                 170                 175     


Gly Tyr Asp Trp Ile Ala Gly Ser Leu Asp Thr Ser Ser Ser Ile Thr 
            180                 185                 190         


Ser Gln Pro Glu Ala Phe Phe Ser Lys Leu Gln Glu Phe Arg Glu Thr 
        195                 200                 205             


Asn Lys Glu Glu Cys Ile Cys Ser His Pro Glu Pro Gln Leu Pro Gly 
    210                 215                 220                 


Leu Arg Glu Ser Ser Gly Ser Gly Val Glu Glu Asp His Glu Cys Val 
225                 230                 235                 240 


Tyr Cys Tyr Arg Val Asn Arg Arg Leu Phe Pro Val Pro Val Asp Pro 
                245                 250                 255     


Gly Thr Pro Cys Arg Leu Cys Arg Thr Pro Arg Asp Gln Gln Gly Pro 
            260                 265                 270         


Gly Thr Leu Ala Gln Pro Ala His Val Arg Val Ser Ile Pro Leu Ser 
        275                 280                 285             


Ile Leu Glu Pro Pro His Arg Tyr His Ile His Arg Arg Lys Ser Phe 
    290                 295                 300                 


Asp Ala Ser Asp Thr Leu Ala Leu Pro Arg His Cys Leu Leu Gly Trp 
305                 310                 315                 320 


Asp Ile Phe Pro Pro Lys Ser Glu Lys Ser Ser Ala Pro Arg Asn Leu 
                325                 330                 335     


Asp Leu Trp Ser Ser Val Ser Ala Glu Ala Gln His Gln Lys Leu Ser 
            340                 345                 350         


Gly Thr Ser Ser Pro Phe His Pro Ala Ser Pro Met Gln Met Leu Pro 
        355                 360                 365             


Pro Thr Pro Thr Trp Ser Val Pro Gln Val Pro Arg Pro His Val Pro 
    370                 375                 380                 


Arg Gln Lys Pro 
385             


<210>  106
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe 
            20                  25                  30          


Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu 
        35                  40                  45              


Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile 
    50                  55                  60                  


Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp 
65                  70                  75                  80  


Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His 
            100                 105                 110         


Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu 
        115                 120                 125             


Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu 
145                 150                 155                 160 


Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly 
                165                 170                 175     


Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr 
225                 230                 235                 240 


Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg 
                245                 250                 255     


Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro 
            260                 265                 270         


Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe 
        275                 280                 285             


Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg 
    290                 295                 300                 


Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu 
305                 310                 315                 320 


Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr 
                325                 330                 335     


Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr 
            340                 345                 350         


Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile 
        355                 360                 365             


His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val 
    370                 375                 380                 


Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr 
385                 390                 395                 400 


Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys 
                405                 410                 415     


Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln 
        435                 440                 445             


Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser 
    450                 455                 460                 


Asn Ser Trp Phe Gly Cys 
465                 470 


<210>  107
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 
1               5                   10                  15      


Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 
            20                  25                  30          


Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 
        35                  40                  45              


Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 
    50                  55                  60                  


Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu 
65                  70                  75                  80  


Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 
                85                  90                  95      


Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 
            100                 105                 110         


Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 
        115                 120                 125             


Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 
    130                 135                 140                 


Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 
145                 150                 155                 160 


Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 
                165                 170                 175     


Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 
            180                 185                 190         


Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 
        195                 200                 205             


Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 
    210                 215                 220                 


Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 
225                 230                 235                 240 


Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 
                245                 250                 255     


Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 
            260                 265         


<210>  108
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Cys Ser Thr Ser Glu Ser 
        195                 200                 205             


Leu Ser Pro Val Lys Gln Ala Pro Arg Lys Ser Pro Ser Asp Thr Glu 
    210                 215                 220                 


Gly Leu Val Lys Ser Leu Pro Ser Gly Ser His Gln Gly Pro Val Ile 
225                 230                 235                 240 


Tyr Ala Gln Leu Asp His Ser Gly Gly His His Ser Asp Lys Ile Asn 
                245                 250                 255     


Lys Ser Glu Ser Val Val Tyr Ala Asp Ile Arg Lys Asn 
            260                 265                 


<210>  109
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Ala Gln Ser Tyr Met His 
        195                 200                 205             


Ser 
    


<210>  110
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Gly Pro Val Ile Tyr Ala Gln Leu Asp His 
                85                  90                  95      


Ser Gly Gly His His Ser Asp Lys Ile Asn Lys Ser Glu Ser Val Val 
            100                 105                 110         


Tyr Ala Asp Ile Arg Lys Asn 
        115                 


<210>  111
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu 
            340                 345                 350         


Val Gly Gly Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser 
        355                 360                 365             


Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly 
    370                 375                 380                 


Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His 
385                 390                 395                 400 


Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu 
                405                 410                 415     


Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg 
            420                 425                 430         


Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr 
        435                 440                 445             


Cys Thr Leu 
    450     


<210>  112
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Arg Pro Val Gln Leu Thr Asp His 
            340                 345                 350         


Ile Arg Ala Gly Pro Ser 
        355             


<210>  113
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Ser Thr Gly Pro Ile Trp Leu Asn 
            340                 345                 350         


Glu Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile 
        355                 360                 365             


Arg Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val 
    370                 375                 380                 


Thr Cys Thr Leu 
385             


<210>  114
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Gln Tyr Ser His His Cys Glu His Leu Leu Glu Arg Leu Asn Lys 
1               5                   10                  15      


Gln Arg Glu Ala Gly Phe Leu Cys Asp Cys Thr Ile Val Ile Gly Glu 
            20                  25                  30          


Phe Gln Phe Lys Ala His Arg Asn Val Leu Ala Ser Phe Ser Glu Tyr 
        35                  40                  45              


Phe Gly Ala Ile Tyr Arg Ser Thr Ser Glu Asn Asn Val Phe Leu Asp 
    50                  55                  60                  


Gln Ser Gln Val Lys Ala Asp Gly Phe Gln Lys Leu Leu Glu Phe Ile 
65                  70                  75                  80  


Tyr Thr Gly Thr Leu Asn Leu Asp Ser Trp Asn Val Lys Glu Ile His 
                85                  90                  95      


Gln Ala Ala Asp Tyr Leu Lys Val Glu Glu Val Val Thr Lys Cys Lys 
            100                 105                 110         


Ile Lys Met Glu Asp Phe Ala Phe Ile Ala Asn Pro Ser Ser Thr Glu 
        115                 120                 125             


Ile Ser Ser Ile Thr Gly Asn Ile Glu Leu Asn Gln Gln Thr Cys Leu 
    130                 135                 140                 


Leu Thr Leu Arg Asp Tyr Asn Asn Arg Glu Lys Ser Glu Val Ser Thr 
145                 150                 155                 160 


Asp Leu Ile Gln Ala Asn Pro Lys Gln Gly Ala Leu Ala Lys Lys Ser 
                165                 170                 175     


Ser Gln Thr Lys Lys Lys Lys Lys Ala Phe Asn Ser Pro Lys Thr Gly 
            180                 185                 190         


Gln Asn Lys Thr Val Gln Tyr Pro Ser Asp Ile Leu Glu Asn Ala Ser 
        195                 200                 205             


Val Glu Leu Phe Leu Asp Ala Asn Lys Leu Pro Thr Pro Val Val Glu 
    210                 215                 220                 


Gln Val Ala Gln Ile Asn Asp Asn Ser Glu Leu Glu Leu Thr Ser Val 
225                 230                 235                 240 


Val Glu Asn Thr Phe Pro Ala Gln Asp Ile Val His Thr Val Thr Val 
                245                 250                 255     


Lys Arg Lys Arg Gly Lys Ser Gln Pro Asn Cys Ala Leu Lys Glu His 
            260                 265                 270         


Ser Met Ser Asn Ile Ala Ser Val Lys Ser Pro Tyr Glu Ala Glu Asn 
        275                 280                 285             


Ser Gly Glu Glu Leu Asp Gln Arg Tyr Ser Lys Ala Lys Pro Met Cys 
    290                 295                 300                 


Asn Thr Cys Gly Lys Val Phe Ser Glu Ala Ser Ser Leu Arg Arg His 
305                 310                 315                 320 


Met Arg Ile His Lys Gly Val Lys Pro Tyr Val Cys His Leu Cys Gly 
                325                 330                 335     


Lys Ala Phe Thr Gln Cys Asn Gln Leu Lys Thr His Val Arg Thr His 
            340                 345                 350         


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Leu Cys Asp Lys Gly Phe Ala 
        355                 360                 365             


Gln Lys Cys Gln Leu Val Phe His Ser Arg Met His His Gly Glu Glu 
    370                 375                 380                 


Lys Pro Tyr Lys Cys Asp Val Cys Asn Leu Gln Phe Ala Thr Ser Ser 
385                 390                 395                 400 


Asn Leu Lys Ile His Ala Arg Lys His Ser Gly Glu Lys Pro Tyr Val 
                405                 410                 415     


Cys Asp Arg Cys Gly Gln Arg Phe Ala Gln Ala Ser Thr Leu Thr Tyr 
            420                 425                 430         


His Val Arg Arg His Thr Gly Glu Lys Pro Tyr Val Cys Asp Thr Cys 
        435                 440                 445             


Gly Lys Ala Phe Ala Val Ser Ser Ser Leu Ile Thr His Ser Arg Lys 
    450                 455                 460                 


His Thr Gly Glu Lys Pro Tyr Ile Cys Gly Ile Cys Gly Lys Ser Phe 
465                 470                 475                 480 


Ile Ser Ser Gly Glu Leu Asn Lys His Phe Arg Ser His Thr Gly Glu 
                485                 490                 495     


Arg Pro Phe Ile Cys Glu Leu Cys Gly Asn Ser Tyr Thr Asp Ile Lys 
            500                 505                 510         


Asn Leu Lys Lys His Lys Thr Lys Val His Ser Gly Ala Asp Lys Thr 
        515                 520                 525             


Leu Asp Ser Ser Ala Glu Asp His Thr Leu Ser Glu Gln Asp Ser Ile 
    530                 535                 540                 


Gln Lys Ser Pro Leu Ser Glu Thr Met Asp Val Lys Pro Ser Asp Met 
545                 550                 555                 560 


Thr Leu Pro Leu Ala Leu Pro Leu Gly Thr Glu Asp His His Met Leu 
                565                 570                 575     


Leu Pro Val Thr Asp Thr Gln Ser Pro Thr Ser Asp Thr Leu Leu Arg 
            580                 585                 590         


Ser Thr Val Asn Gly Tyr Ser Glu Pro Gln Leu Ile Phe Leu Gln Gln 
        595                 600                 605             


Leu Tyr 
    610 


<210>  115
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Gln Tyr Ser His His Cys Glu His Leu Leu Glu Arg Leu Asn Lys 
1               5                   10                  15      


Gln Arg Glu Ala Gly Phe Leu Cys Asp Cys Thr Ile Val Ile Gly Glu 
            20                  25                  30          


Phe Gln Phe Lys Ala His Arg Asn Val Leu Ala Ser Phe Ser Glu Tyr 
        35                  40                  45              


Phe Gly Ala Ile Tyr Arg Ser Thr Ser Glu Asn Asn Val Phe Leu Asp 
    50                  55                  60                  


Gln Ser Gln Val Lys Ala Asp Gly Phe Gln Lys Leu Leu Glu Phe Ile 
65                  70                  75                  80  


Tyr Thr Gly Thr Leu Asn Leu Asp Ser Trp Asn Val Lys Glu Ile His 
                85                  90                  95      


Gln Ala Ala Asp Tyr Leu Lys Val Glu Glu Val Val Thr Lys Cys Lys 
            100                 105                 110         


Ile Lys Met Glu Asp Phe Ala Phe Ile Ala Asn Pro Ser Ser Thr Glu 
        115                 120                 125             


Ile Ser Ser Ile Thr Gly Asn Ile Glu Leu Asn Gln Gln Thr Cys Leu 
    130                 135                 140                 


Leu Thr Leu Arg Asp Tyr Asn Asn Arg Glu Lys Ser Glu Val Ser Thr 
145                 150                 155                 160 


Asp Leu Ile Gln Ala Asn Pro Lys Gln Gly Ala Leu Ala Lys Lys Ser 
                165                 170                 175     


Ser Gln Thr Lys Lys Lys Lys Lys Ala Phe Asn Ser Pro Lys Thr Gly 
            180                 185                 190         


Gln Asn Lys Thr Val Gln Tyr Pro Ser Asp Ile Leu Glu Asn Ala Ser 
        195                 200                 205             


Val Glu Leu Phe Leu Asp Ala Asn Lys Leu Pro Thr Pro Val Val Glu 
    210                 215                 220                 


Gln Val Ala Gln Ile Asn Asp Asn Ser Glu Leu Glu Leu Thr Ser Val 
225                 230                 235                 240 


Val Glu Asn Thr Phe Pro Ala Gln Asp Ile Val His Thr Val Thr Val 
                245                 250                 255     


Lys Arg Lys Arg Gly Lys Ser Gln Pro Asn Cys Ala Leu Lys Glu His 
            260                 265                 270         


Ser Met Ser Asn Ile Ala Ser Val Lys Ser Pro Tyr Glu Ala Glu Asn 
        275                 280                 285             


Ser Gly Glu Glu Leu Asp Gln Arg Tyr Ser Lys Ala Lys Pro Met Cys 
    290                 295                 300                 


Asn Thr Cys Gly Lys Val Phe Ser Glu Ala Ser Ser Leu Arg Arg His 
305                 310                 315                 320 


Met Arg Ile His Lys Gly Val Lys Pro Tyr Val Cys His Leu Cys Gly 
                325                 330                 335     


Lys Ala Phe Thr Gln Cys Asn Gln Leu Lys Thr His Val Arg Thr His 
            340                 345                 350         


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Leu Cys Asp Lys Gly Phe Ala 
        355                 360                 365             


Gln Lys Cys Gln Leu Val Phe His Ser Arg Met His His Gly Glu Glu 
    370                 375                 380                 


Lys Pro Tyr Lys Cys Asp Val Cys Asn Leu Gln Phe Ala Thr Ser Ser 
385                 390                 395                 400 


Asn Leu Lys Ile His Ala Arg Lys His Ser Gly Glu Lys Pro Tyr Val 
                405                 410                 415     


Cys Asp Arg Cys Gly Gln Arg Phe Ala Gln Ala Ser Thr Leu Thr Tyr 
            420                 425                 430         


His Val Arg Arg His Thr Gly Glu Lys Pro Tyr Val Cys Asp Thr Cys 
        435                 440                 445             


Gly Lys Ala Phe Ala Val Ser Ser Ser Leu Ile Thr His Ser Arg Lys 
    450                 455                 460                 


His Thr Gly Glu Lys Pro Tyr Ile Cys Gly Ile Cys Gly Lys Ser Phe 
465                 470                 475                 480 


Ile Ser Ser Gly Glu Leu Asn Lys His Phe Arg Ser His Thr Gly Ala 
                485                 490                 495     


Asp Lys Thr Leu Asp Ser Ser Ala Glu Asp His Thr Leu Ser Glu Gln 
            500                 505                 510         


Asp Ser Ile Gln Lys Ser Pro Leu Ser Glu Thr Met Asp Val Lys Pro 
        515                 520                 525             


Ser Asp Met Thr Leu Pro Leu Ala Leu Pro Leu Gly Thr Glu Asp His 
    530                 535                 540                 


His Met Leu Leu Pro Val Thr Asp Thr Gln Ser Pro Thr Ser Asp Thr 
545                 550                 555                 560 


Leu Leu Arg Ser Thr Val Asn Gly Tyr Ser Glu Pro Gln Leu Ile Phe 
                565                 570                 575     


Leu Gln Gln Leu Tyr 
            580     


<210>  116
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Arg Thr Arg Thr Gly Ser Gln Leu Ala Ala Arg Glu Val Thr Gly 
1               5                   10                  15      


Ser Gly Ala Val Pro Arg Gln Leu Glu Gly Arg Arg Cys Gln Ala Gly 
            20                  25                  30          


Arg Asp Ala Asn Gly Gly Thr Ser Ser Asp Gly Ser Ser Ser Met Ala 
        35                  40                  45              


Ala Ile Tyr Gly Gly Val Glu Gly Gly Gly Thr Arg Ser Glu Val Leu 
    50                  55                  60                  


Leu Val Ser Glu Asp Gly Lys Ile Leu Ala Glu Ala Asp Gly Leu Ser 
65                  70                  75                  80  


Thr Asn His Trp Leu Ile Gly Thr Asp Lys Cys Val Glu Arg Ile Asn 
                85                  90                  95      


Glu Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp Pro Leu Val 
            100                 105                 110         


Pro Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp Gln Glu Asp 
        115                 120                 125             


Ala Gly Arg Ile Leu Ile Glu Glu Leu Arg Asp Arg Phe Pro Tyr Leu 
    130                 135                 140                 


Ser Glu Ser Tyr Leu Ile Thr Thr Asp Ala Ala Gly Ser Ile Ala Thr 
145                 150                 155                 160 


Ala Thr Pro Asp Gly Gly Val Val Leu Ile Ser Gly Thr Gly Ser Asn 
                165                 170                 175     


Cys Arg Leu Ile Asn Pro Asp Gly Ser Glu Ser Gly Cys Gly Gly Trp 
            180                 185                 190         


Gly His Met Met Gly Asp Glu Gly Ser Ala Tyr Trp Ile Ala His Gln 
        195                 200                 205             


Ala Val Lys Ile Val Phe Asp Ser Ile Asp Asn Leu Glu Ala Ala Pro 
    210                 215                 220                 


His Asp Ile Gly Tyr Val Lys Gln Ala Met Phe His Tyr Phe Gln Val 
225                 230                 235                 240 


Pro Asp Arg Leu Gly Ile Leu Thr His Leu Tyr Arg Asp Phe Asp Lys 
                245                 250                 255     


Cys Arg Phe Ala Gly Phe Cys Arg Lys Ile Ala Glu Gly Ala Gln Gln 
            260                 265                 270         


Gly Asp Pro Leu Ser Arg Tyr Ile Phe Arg Lys Ala Gly Glu Met Leu 
        275                 280                 285             


Gly Arg His Ile Val Ala Val Leu Pro Glu Ile Asp Pro Val Leu Phe 
    290                 295                 300                 


Gln Gly Lys Ile Gly Leu Pro Ile Leu Cys Val Gly Ser Val Trp Lys 
305                 310                 315                 320 


Ser Trp Glu Leu Leu Lys Glu Gly Phe Leu Leu Ala Leu Thr Gln Gly 
                325                 330                 335     


Arg Glu Ile Gln Ala Gln Asn Phe Phe Ser Ser Phe Thr Leu Met Lys 
            340                 345                 350         


Leu Arg His Ser Ser Ala Leu Gly Gly Ala Ser Leu Gly Ala Arg His 
        355                 360                 365             


Ile Gly His Leu Leu Pro Met Asp Tyr Ser Ala Asn Ala Ile Ala Phe 
    370                 375                 380                 


Tyr Ser Tyr Thr Phe Ser 
385                 390 


<210>  117
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp Pro Leu Val Pro 
1               5                   10                  15      


Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp Gln Glu Asp Ala 
            20                  25                  30          


Gly Arg Ile Leu Ile Glu Glu Leu Arg Asp Arg Phe Pro Tyr Leu Ser 
        35                  40                  45              


Glu Ser Tyr Leu Ile Thr Thr Asp Ala Ala Gly Ser Ile Ala Thr Ala 
    50                  55                  60                  


Thr Pro Asp Gly Gly Val Val Leu Ile Ser Gly Thr Gly Ser Asn Cys 
65                  70                  75                  80  


Arg Leu Ile Asn Pro Asp Gly Ser Glu Ser Gly Cys Gly Gly Trp Gly 
                85                  90                  95      


His Met Met Gly Asp Glu Gly Ser Ala Tyr Trp Ile Ala His Gln Ala 
            100                 105                 110         


Val Lys Ile Val Phe Asp Ser Ile Asp Asn Leu Glu Ala Ala Pro His 
        115                 120                 125             


Asp Ile Gly Tyr Val Lys Gln Ala Met Phe His Tyr Phe Gln Val Pro 
    130                 135                 140                 


Asp Arg Leu Gly Ile Leu Thr His Leu Tyr Arg Asp Phe Asp Lys Cys 
145                 150                 155                 160 


Arg Phe Ala Gly Phe Cys Arg Lys Ile Ala Glu Gly Ala Gln Gln Gly 
                165                 170                 175     


Asp Pro Leu Ser Arg Tyr Ile Phe Arg Lys Ala Gly Glu Met Leu Gly 
            180                 185                 190         


Arg His Ile Val Ala Val Leu Pro Glu Ile Asp Pro Val Leu Phe Gln 
        195                 200                 205             


Gly Lys Ile Gly Leu Pro Ile Leu Cys Val Gly Ser Val Trp Lys Ser 
    210                 215                 220                 


Trp Glu Leu Leu Lys Glu Gly Phe Leu Leu Ala Leu Thr Gln Gly Arg 
225                 230                 235                 240 


Glu Ile Gln Ala Gln Asn Phe Phe Ser Ser Phe Thr Leu Met Lys Leu 
                245                 250                 255     


Arg His Ser Ser Ala Leu Gly Gly Ala Ser Leu Gly Ala Arg His Ile 
            260                 265                 270         


Gly His Leu Leu Pro Met Asp Tyr Ser Ala Asn Ala Ile Ala Phe Tyr 
        275                 280                 285             


Ser Tyr Thr Phe Ser 
    290             


<210>  118
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Ser Pro Pro Pro Leu Leu Gln Pro Leu Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Asn Val Glu Pro Ser Gly Ala Thr Leu Ile Arg Ile Pro Leu His 
            20                  25                  30          


Arg Val Gln Pro Gly Arg Arg Ile Leu Asn Leu Leu Arg Gly Trp Arg 
        35                  40                  45              


Glu Pro Ala Glu Leu Pro Lys Leu Gly Ala Pro Ser Pro Gly Asp Lys 
    50                  55                  60                  


Pro Ile Phe Val Pro Leu Ser Asn Tyr Arg Asp Val Gln Tyr Phe Gly 
65                  70                  75                  80  


Glu Ile Gly Leu Gly Thr Pro Pro Gln Asn Phe Thr Val Ala Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Arg Arg Cys His Phe Phe 
            100                 105                 110         


Ser Val Pro Cys Trp Leu His His Arg Phe Asp Pro Lys Ala Ser Ser 
        115                 120                 125             


Ser Phe Gln Ala Asn Gly Thr Lys Phe Ala Ile Gln Tyr Gly Thr Gly 
    130                 135                 140                 


Arg Val Asp Gly Ile Leu Ser Glu Asp Lys Leu Thr Ile Gly Gly Ile 
145                 150                 155                 160 


Lys Gly Ala Ser Val Ile Phe Gly Glu Ala Leu Trp Glu Pro Ser Leu 
                165                 170                 175     


Val Phe Ala Phe Ala His Phe Asp Gly Ile Leu Gly Leu Gly Phe Pro 
            180                 185                 190         


Ile Leu Ser Val Glu Gly Val Arg Pro Pro Met Asp Val Leu Val Glu 
        195                 200                 205             


Gln Gly Leu Leu Asp Lys Pro Val Phe Ser Phe Tyr Leu Asn Arg Asp 
    210                 215                 220                 


Pro Glu Glu Pro Asp Gly Gly Glu Leu Val Leu Gly Gly Ser Asp Pro 
225                 230                 235                 240 


Ala His Tyr Ile Pro Pro Leu Thr Phe Val Pro Val Thr Val Pro Ala 
                245                 250                 255     


Tyr Trp Gln Ile His Met Glu Arg Val Lys Val Gly Pro Gly Leu Thr 
            260                 265                 270         


Leu Cys Ala Lys Gly Cys Ala Ala Ile Leu Asp Thr Gly Thr Ser Leu 
        275                 280                 285             


Ile Thr Gly Pro Thr Glu Glu Ile Arg Ala Leu His Ala Ala Ile Gly 
    290                 295                 300                 


Gly Ile Pro Leu Leu Ala Gly Glu Tyr Ile Ile Leu Cys Ser Glu Ile 
305                 310                 315                 320 


Pro Lys Leu Pro Ala Val Ser Phe Leu Leu Gly Gly Val Trp Phe Asn 
                325                 330                 335     


Leu Thr Ala His Asp Tyr Val Ile Gln Thr Thr Arg Asn Gly Val Arg 
            340                 345                 350         


Leu Cys Leu Ser Gly Phe Gln Ala Leu Asp Val Pro Pro Pro Ala Gly 
        355                 360                 365             


Pro Phe Trp Ile Leu Gly Asp Val Phe Leu Gly Thr Tyr Val Ala Val 
    370                 375                 380                 


Phe Asp Arg Gly Asp Met Lys Ser Ser Ala Arg Val Gly Leu Ala Arg 
385                 390                 395                 400 


Ala Arg Thr Arg Gly Ala Asp Leu Gly Trp Gly Glu Thr Ala Gln Ala 
                405                 410                 415     


Gln Phe Pro Gly 
            420 


<210>  119
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
            180                 185                 190         


Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
        195                 200                 205             


Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
    210                 215                 220                 


Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
225                 230                 235                 240 


Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                245                 250                 255     


Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
            260                 265                 270         


Asn Ala Gln Gln Gly Gln Arg Asn Ala Ser Gln Gly Lys Pro Arg Arg 
        275                 280                 285             


Cys Leu Lys Glu Thr Leu Gln Ile Thr Gln Thr Glu Val Gln Gln Gly 
    290                 295                 300                 


Gln Gln Gln Phe Ser Gln Phe Thr Asp Gly Gln Gln Leu Tyr Gln Ile 
305                 310                 315                 320 


Gln Gln Val Thr Met Pro Ala Gly Gln Asp Leu Ala Gln Pro Met Phe 
                325                 330                 335     


Ile Gln Ser Ala Asn Gln Pro Ser Asp Gly Gln Ala Pro Gln Val Thr 
            340                 345                 350         


Gly Asp 
        


<210>  120
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
            180                 185                 190         


Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
        195                 200                 205             


Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
    210                 215                 220                 


Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
225                 230                 235                 240 


Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                245                 250                 255     


Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
            260                 265                 270         


Asn Ala Gln Gln Ile Thr Gln Thr Glu Val Gln Gln Gly Gln Gln Gln 
        275                 280                 285             


Phe Ser Gln Phe Thr Asp Gly Gln Gln Leu Tyr Gln Ile Gln Gln Val 
    290                 295                 300                 


Thr Met Pro Ala Gly Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser 
305                 310                 315                 320 


Ala Asn Gln Pro Ser Asp Gly Gln Ala Pro Gln Val Thr Gly Asp 
                325                 330                 335 


<210>  121
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
            180                 185                 190         


Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
        195                 200                 205             


Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
    210                 215                 220                 


Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
225                 230                 235                 240 


Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                245                 250                 255     


Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
            260                 265                 270         


Asn Ala Gln Gln Ile Thr Gln Thr Glu Val Gln Gln Gly Gln Gln Gln 
        275                 280                 285             


Phe Ser Gln Phe Thr Asp Gly Gln Leu Tyr Gln Ile Gln Gln Val Thr 
    290                 295                 300                 


Met Pro Ala Gly Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser Ala 
305                 310                 315                 320 


Asn Gln Pro Ser Asp Gly Gln Ala Pro Gln Val Thr Gly Asp 
                325                 330                 


<210>  122
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Arg Asn Asp Ile Ala 
    50                  55                  60                  


Met Ala Ile Thr Lys Phe Asp Gln Phe Asp Phe Leu Ile Asp Ile Val 
65                  70                  75                  80  


Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg Gln Glu Glu Val Arg Gln 
                85                  90                  95      


Ser Val Thr Pro Ala Glu Pro Val Gln Tyr Tyr Phe Thr Leu Ala Gln 
            100                 105                 110         


Gln Pro Thr Ala Val Gln Val Gln Gly Gln Gln Gln Gly Gln Gln Thr 
        115                 120                 125             


Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly Gln Ile Ile Ile Ala Gln 
    130                 135                 140                 


Pro Gln Gln Gly Gln Thr Thr Pro Val Thr Met Gln Val Gly Glu Gly 
145                 150                 155                 160 


Gln Gln Val Gln Ile Val Gln Ala Gln Pro Gln Gly Gln Ala Gln Gln 
                165                 170                 175     


Ala Gln Ser Gly Thr Gly Gln Thr Met Gln Val Met Gln Gln Ile Ile 
            180                 185                 190         


Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro Val Gln Leu Asn Ala Gly 
        195                 200                 205             


Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro Val Ser Gly Thr Gln Val 
    210                 215                 220                 


Val Gln Gly Gln Ile Gln Thr Leu Ala Thr Asn Ala Gln Gln Ile Thr 
225                 230                 235                 240 


Gln Thr Glu Val Gln Gln Gly Gln Gln Gln Phe Ser Gln Phe Thr Asp 
                245                 250                 255     


Gly Gln Gln Leu Tyr Gln Ile Gln Gln Val Thr Met Pro Ala Gly Gln 
            260                 265                 270         


Asp Leu Ala Gln Pro Met Phe Ile Gln Ser Ala Asn Gln Pro Ser Asp 
        275                 280                 285             


Gly Gln Ala Pro Gln Val Thr Gly Asp 
    290                 295         


<210>  123
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Met Gln Val Met 
            180                 185                 190         


Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro Val Gln 
        195                 200                 205             


Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro Val Ser 
    210                 215                 220                 


Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr Asn Ala 
225                 230                 235                 240 


Gln Gln Ile Thr Gln Thr Glu Val Gln Gln Gly Gln Gln Gln Phe Ser 
                245                 250                 255     


Gln Phe Thr Asp Gly Gln Gln Leu Tyr Gln Ile Gln Gln Val Thr Met 
            260                 265                 270         


Pro Ala Gly Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser Ala Asn 
        275                 280                 285             


Gln Pro Ser Asp Gly Gln Ala Pro Gln Val Thr Gly Asp 
    290                 295                 300     


<210>  124
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
            180                 185                 190         


Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
        195                 200                 205             


Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
    210                 215                 220                 


Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
225                 230                 235                 240 


Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                245                 250                 255     


Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
            260                 265                 270         


Asn Ala Gln Gln Gly Gln Arg Asn Ala Ser Gln Gly Lys Pro Arg Arg 
        275                 280                 285             


Cys Leu Lys Glu Thr Leu Gln Ile Thr Gln Thr Glu Val Gln Gln Gly 
    290                 295                 300                 


Gln Gln Gln Phe Ser Gln Phe Thr Asp Gly Gln Arg Asn Ser Val Gln 
305                 310                 315                 320 


Gln Ala Arg Val Ser Glu Leu Thr Gly Glu Ala Glu Pro Arg Glu Val 
                325                 330                 335     


Lys Ala Thr Gly Asn Ser Thr Pro Cys Thr Ser Ser Leu Pro Thr Thr 
            340                 345                 350         


His Pro Pro Ser His Arg Ala Gly Ala Ser Cys Val Cys Cys Ser Gln 
        355                 360                 365             


Pro Gln Gln Ser Ser Thr Ser Pro Pro Pro Ser Asp Ala Leu Gln Trp 
    370                 375                 380                 


Val Val Val Glu Val Ser Gly Thr Pro Asn Gln Leu Glu Thr His Arg 
385                 390                 395                 400 


Glu Leu His Ala Pro Leu Pro Gly Met Thr Ser Leu Ser Pro Leu His 
                405                 410                 415     


Pro Ser Gln Gln Leu Tyr Gln Ile Gln Gln Val Thr Met Pro Ala Gly 
            420                 425                 430         


Gln Asp Leu Ala Gln Pro Met Phe Ile Gln Ser Ala Asn Gln Pro Ser 
        435                 440                 445             


Asp Gly Gln Ala Pro Gln Val Thr Gly Asp 
    450                 455             


<210>  125
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ser Thr Glu Gly Gly Phe Gly Gly Thr Ser Ser Ser Asp Ala Gln 
1               5                   10                  15      


Gln Ser Leu Gln Ser Phe Trp Pro Arg Val Met Glu Glu Ile Arg Asn 
            20                  25                  30          


Leu Thr Val Lys Asp Phe Arg Val Gln Glu Leu Pro Leu Ala Arg Ile 
        35                  40                  45              


Lys Lys Ile Met Lys Leu Asp Glu Asp Val Lys Met Ile Ser Ala Glu 
    50                  55                  60                  


Ala Pro Val Leu Phe Ala Lys Ala Ala Gln Ile Phe Ile Thr Glu Leu 
65                  70                  75                  80  


Thr Leu Arg Ala Trp Ile His Thr Glu Asp Asn Lys Arg Arg Thr Leu 
                85                  90                  95      


Gln Arg Asn Asp Ile Ala Met Ala Ile Thr Lys Phe Asp Gln Phe Asp 
            100                 105                 110         


Phe Leu Ile Asp Ile Val Pro Arg Asp Glu Leu Lys Pro Pro Lys Arg 
        115                 120                 125             


Gln Glu Glu Val Arg Gln Ser Val Thr Pro Ala Glu Pro Val Gln Tyr 
    130                 135                 140                 


Tyr Phe Thr Leu Ala Gln Gln Pro Thr Ala Val Gln Val Gln Gly Gln 
145                 150                 155                 160 


Gln Gln Gly Gln Gln Thr Thr Ser Ser Thr Thr Thr Ile Gln Pro Gly 
                165                 170                 175     


Gln Ile Ile Ile Ala Gln Pro Gln Gln Gly Gln Thr Thr Pro Val Thr 
            180                 185                 190         


Met Gln Val Gly Glu Gly Gln Gln Val Gln Ile Val Gln Ala Gln Pro 
        195                 200                 205             


Gln Gly Gln Ala Gln Gln Ala Gln Ser Gly Thr Gly Gln Thr Met Gln 
    210                 215                 220                 


Val Met Gln Gln Ile Ile Thr Asn Thr Gly Glu Ile Gln Gln Ile Pro 
225                 230                 235                 240 


Val Gln Leu Asn Ala Gly Gln Leu Gln Tyr Ile Arg Leu Ala Gln Pro 
                245                 250                 255     


Val Ser Gly Thr Gln Val Val Gln Gly Gln Ile Gln Thr Leu Ala Thr 
            260                 265                 270         


Asn Ala Gln Gln Ile Thr Gln Thr Glu Val Gln Gln Gly Gln Gln Gln 
        275                 280                 285             


Phe Ser Gln Phe Thr Asp Gly Gln Arg Asn Ser Val Gln Gln Ala Arg 
    290                 295                 300                 


Val Ser Glu Leu Thr Gly Glu Ala Glu Pro Arg Glu Val Lys Ala Thr 
305                 310                 315                 320 


Gly Asn Ser Thr Pro Cys Thr Ser Ser Leu Pro Thr Thr His Pro Pro 
                325                 330                 335     


Ser His Arg Ala Gly Ala Ser Cys Val Cys Cys Ser Gln Pro Gln Gln 
            340                 345                 350         


Ser Ser Thr Ser Pro Pro Pro Ser Asp Ala Leu Gln Trp Val Val Val 
        355                 360                 365             


Glu Val Ser Gly Thr Pro Asn Gln Leu Glu Thr His Arg Glu Leu His 
    370                 375                 380                 


Ala Pro Leu Pro Gly Met Thr Ser Leu Ser Pro Leu His Pro Ser Gln 
385                 390                 395                 400 


Gln Leu Tyr Gln Ile Gln Gln Val Thr Met Pro Ala Gly Gln Asp Leu 
                405                 410                 415     


Ala Gln Pro Met Phe Ile Gln Ser Ala Asn Gln Pro Ser Asp Gly Gln 
            420                 425                 430         


Ala Pro Gln Val Thr Gly Asp 
        435                 


<210>  126
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Gly Phe Met Leu Pro Leu Ile Phe Arg Tyr Ser Pro Arg Leu Met 
1               5                   10                  15      


Glu Lys Ile Leu Gln Met Ala Glu Gly Ile Asp Ile Gly Glu Met Pro 
            20                  25                  30          


Ser Tyr Asp Leu Val Leu Ser Lys Pro Ser Lys Gly Gln Lys Arg His 
        35                  40                  45              


Leu Ser Thr Cys Asp Gly Gln Asn Pro Pro Lys Lys Gln Ala Gly Ser 
    50                  55                  60                  


Lys Phe His Ala Arg Pro Arg Phe Glu Pro Val His Phe Val Ala Ser 
65                  70                  75                  80  


Ser Ser Lys Asp Glu Arg Gln Glu Asp Pro Tyr Gly Pro Gln Thr Lys 
                85                  90                  95      


Glu Val Asn Glu Gln Thr His Phe Ala Ser Met Pro Arg Asp Ile Tyr 
            100                 105                 110         


Gln Asp Tyr Thr Gln Asp Ser Phe Ser Ile Gln Asp Gly Asn Ser Gln 
        115                 120                 125             


Tyr Cys Asp Ser Ser Gly Phe Ile Leu Thr Lys Asp Gln Pro Val Thr 
    130                 135                 140                 


Ala Asn Met Tyr Phe Asp Ser Gly Asn Pro Ala Pro Ser Thr Thr Ser 
145                 150                 155                 160 


Gln Gln Ala Asn Ser Gln Ser Thr Pro Glu Pro Ser Pro Ser Gln Thr 
                165                 170                 175     


Phe Pro Glu Ser Val Val Ala Glu Lys Gln Tyr Phe Ile Glu Lys Leu 
            180                 185                 190         


Thr Ala Thr Ile Trp Lys Asn Leu Ser Asn Pro Glu Met Thr Ser Gly 
        195                 200                 205             


Ser Asp Lys Ile Asn Tyr Thr Tyr Met Leu Thr Arg Cys Ile Gln Ala 
    210                 215                 220                 


Cys Lys Thr Asn Pro Glu Tyr Ile Tyr Ala Pro Leu Lys Glu Ile Pro 
225                 230                 235                 240 


Pro Ala Asp Ile Pro Lys Asn Lys Lys Leu Leu Thr Asp Gly Tyr Ala 
                245                 250                 255     


Cys Glu Val Arg Cys Gln Asn Ile Tyr Leu Thr Thr Gly Tyr Ala Gly 
            260                 265                 270         


Ser Lys Asn Gly Ser Arg Asp Arg Ala Thr Glu Leu Ala Val Lys Leu 
        275                 280                 285             


Leu Gln Lys Arg Ile Glu Val Arg Val Val Arg Arg Lys Phe Lys His 
    290                 295                 300                 


Thr Phe Gly Glu Asp Leu Val Val Cys Gln Ile Gly Met Ser Ser Tyr 
305                 310                 315                 320 


Glu Phe Pro Pro Ala Leu Lys Pro Pro Glu Asp Leu Val Val Leu Gly 
                325                 330                 335     


Lys Asp Ala Ser Gly Gln Pro Ile Phe Asn Ala Ser Ala Lys His Trp 
            340                 345                 350         


Thr Asn Phe Val Ile Thr Glu Asn Ala Asn Asp Ala Ile Gly Ile Leu 
        355                 360                 365             


Asn Asn Ser Ala Ser Phe Asn Lys Met Ser Ile Glu Tyr Lys Tyr Glu 
    370                 375                 380                 


Met Met Pro Asn Arg Thr Trp Arg Cys Arg Val Phe Leu Gln Asp His 
385                 390                 395                 400 


Cys Leu Ala Glu Gly Tyr Gly Thr Lys Lys Thr Ser Lys His Ala Ala 
                405                 410                 415     


Ala Asp Glu Ala Leu Lys Ile Leu Gln Lys Thr Gln Pro Thr Tyr Pro 
            420                 425                 430         


Ser Val Lys Ser Ser Gln Cys His Thr Gly Ser Ser Pro Arg Gly Ser 
        435                 440                 445             


Gly Lys Lys Lys Asp Ile Lys Asp Leu Val Val Tyr Glu Asn Ser Ser 
    450                 455                 460                 


Asn Pro Val Cys Thr Leu Asn Asp Thr Ala Gln Phe Asn Arg Met Thr 
465                 470                 475                 480 


Val Glu Tyr Val Tyr Glu Arg Met Thr Gly Leu Arg Trp Lys Cys Lys 
                485                 490                 495     


Val Ile Leu Glu Ser Glu Val Ile Ala Glu Ala Val Gly Val Lys Lys 
            500                 505                 510         


Thr Val Lys Tyr Glu Ala Ala Gly Glu Ala Val Lys Thr Leu Lys Lys 
        515                 520                 525             


Thr Gln Pro Thr Val Ile Asn Asn Leu Lys Lys Gly Ala Val Glu Asp 
    530                 535                 540                 


Val Ile Ser Arg Asn Glu Ile Gln Gly Arg Ser Ala Glu Glu Ala Tyr 
545                 550                 555                 560 


Lys Gln Gln Ile Lys Glu Asp Asn Ile Gly Asn Gln Leu Leu Arg Lys 
                565                 570                 575     


Met Gly Trp Thr Gly Gly Gly Leu Gly Lys Ser Gly Glu Gly Ile Arg 
            580                 585                 590         


Glu Pro Ile Ser Val Lys Glu Gln His Lys Arg Glu Gly Leu Gly Leu 
        595                 600                 605             


Asp Val Glu Arg Val Asn Lys Ile Ala Lys Arg Asp Ile Glu Gln Ile 
    610                 615                 620                 


Ile Arg Asn Tyr Ala Arg Ser Glu Ser His Thr Asp Leu Thr Phe Ser 
625                 630                 635                 640 


Arg Glu Leu Thr Asn Asp Glu Arg Lys Gln Ile His Gln Ile Ala Gln 
                645                 650                 655     


Lys Tyr Gly Leu Lys Ser Lys Ser His Gly Val Gly His Asp Arg Tyr 
            660                 665                 670         


Leu Val Val Gly Arg Lys Arg Arg Lys Glu Asp Leu Leu Asp Gln Leu 
        675                 680                 685             


Lys Gln Glu Gly Gln Val Gly His Tyr Glu Leu Val Met Pro Gln Ala 
    690                 695                 700                 


Asn 
705 


<210>  127
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Glu Lys Ile Leu Gln Met Ala Glu Gly Ile Asp Ile Gly Glu Met 
1               5                   10                  15      


Pro Ser Tyr Asp Leu Val Leu Ser Lys Pro Ser Lys Gly Gln Lys Arg 
            20                  25                  30          


His Leu Ser Thr Cys Asp Gly Gln Asn Pro Pro Lys Lys Gln Ala Gly 
        35                  40                  45              


Ser Lys Phe His Ala Arg Pro Arg Phe Glu Pro Val His Phe Val Ala 
    50                  55                  60                  


Ser Ser Ser Lys Asp Glu Arg Gln Glu Asp Pro Tyr Gly Pro Gln Thr 
65                  70                  75                  80  


Lys Glu Val Asn Glu Gln Thr His Phe Ala Ser Met Pro Arg Asp Ile 
                85                  90                  95      


Tyr Gln Asp Tyr Thr Gln Asp Ser Phe Ser Ile Gln Asp Gly Asn Ser 
            100                 105                 110         


Gln Tyr Cys Asp Ser Ser Gly Phe Ile Leu Thr Lys Asp Gln Pro Val 
        115                 120                 125             


Thr Ala Asn Met Tyr Phe Asp Ser Gly Asn Pro Ala Pro Ser Thr Thr 
    130                 135                 140                 


Ser Gln Gln Ala Asn Ser Gln Ser Thr Pro Glu Pro Ser Pro Ser Gln 
145                 150                 155                 160 


Thr Phe Pro Glu Ser Val Val Ala Glu Lys Gln Tyr Phe Ile Glu Lys 
                165                 170                 175     


Leu Thr Ala Thr Ile Trp Lys Asn Leu Ser Asn Pro Glu Met Thr Ser 
            180                 185                 190         


Gly Ser Asp Lys Ile Asn Tyr Thr Tyr Met Leu Thr Arg Cys Ile Gln 
        195                 200                 205             


Ala Cys Lys Thr Asn Pro Glu Tyr Ile Tyr Ala Pro Leu Lys Glu Ile 
    210                 215                 220                 


Pro Pro Ala Asp Ile Pro Lys Asn Lys Lys Leu Leu Thr Asp Gly Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Arg Cys Gln Asn Ile Tyr Leu Thr Thr Gly Tyr Ala 
                245                 250                 255     


Gly Ser Lys Asn Gly Ser Arg Asp Arg Ala Thr Glu Leu Ala Val Lys 
            260                 265                 270         


Leu Leu Gln Lys Arg Ile Glu Val Arg Val Val Arg Arg Lys Phe Lys 
        275                 280                 285             


His Thr Phe Gly Glu Asp Leu Val Val Cys Gln Ile Gly Met Ser Ser 
    290                 295                 300                 


Tyr Glu Phe Pro Pro Ala Leu Lys Pro Pro Glu Asp Leu Val Val Leu 
305                 310                 315                 320 


Gly Lys Asp Ala Ser Gly Gln Pro Ile Phe Asn Ala Ser Ala Lys His 
                325                 330                 335     


Trp Thr Asn Phe Val Ile Thr Glu Asn Ala Asn Asp Ala Ile Gly Ile 
            340                 345                 350         


Leu Asn Asn Ser Ala Ser Phe Asn Lys Met Ser Ile Glu Tyr Lys Tyr 
        355                 360                 365             


Glu Met Met Pro Asn Arg Thr Trp Arg Cys Arg Val Phe Leu Gln Asp 
    370                 375                 380                 


His Cys Leu Ala Glu Gly Tyr Gly Thr Lys Lys Thr Ser Lys His Ala 
385                 390                 395                 400 


Ala Ala Asp Glu Ala Leu Lys Ile Leu Gln Lys Thr Gln Pro Thr Tyr 
                405                 410                 415     


Pro Ser Val Lys Ser Ser Gln Cys His Thr Gly Ser Ser Pro Arg Gly 
            420                 425                 430         


Ser Gly Lys Lys Lys Asp Ile Lys Asp Leu Val Val Tyr Glu Asn Ser 
        435                 440                 445             


Ser Asn Pro Val Cys Thr Leu Asn Asp Thr Ala Gln Phe Asn Arg Met 
    450                 455                 460                 


Thr Val Glu Tyr Val Tyr Glu Arg Met Thr Gly Leu Arg Trp Lys Cys 
465                 470                 475                 480 


Lys Val Ile Leu Glu Ser Glu Val Ile Ala Glu Ala Val Gly Val Lys 
                485                 490                 495     


Lys Thr Val Lys Tyr Glu Ala Ala Gly Glu Ala Val Lys Thr Leu Lys 
            500                 505                 510         


Lys Thr Gln Pro Thr Val Ile Asn Asn Leu Lys Lys Gly Ala Val Glu 
        515                 520                 525             


Asp Val Ile Ser Arg Asn Glu Ile Gln Gly Arg Ser Ala Glu Glu Ala 
    530                 535                 540                 


Tyr Lys Gln Gln Ile Lys Glu Asp Asn Ile Gly Asn Gln Leu Leu Arg 
545                 550                 555                 560 


Lys Met Gly Trp Thr Gly Gly Gly Leu Gly Lys Ser Gly Glu Gly Ile 
                565                 570                 575     


Arg Glu Pro Ile Ser Val Lys Glu Gln His Lys Arg Glu Gly Leu Gly 
            580                 585                 590         


Leu Asp Val Glu Arg Val Asn Lys Ile Ala Lys Arg Asp Ile Glu Gln 
        595                 600                 605             


Ile Ile Arg Asn Tyr Ala Arg Ser Glu Ser His Thr Asp Leu Thr Phe 
    610                 615                 620                 


Ser Arg Glu Leu Thr Asn Asp Glu Arg Lys Gln Ile His Gln Ile Ala 
625                 630                 635                 640 


Gln Lys Tyr Gly Leu Lys Ser Lys Ser His Gly Val Gly His Asp Arg 
                645                 650                 655     


Tyr Leu Val Val Gly Arg Lys Arg Arg Lys Glu Asp Leu Leu Asp Gln 
            660                 665                 670         


Leu Lys Gln Glu Gly Gln Val Gly His Tyr Glu Leu Val Met Pro Gln 
        675                 680                 685             


Ala Asn 
    690 


<210>  128
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210>  129
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Val Phe His Leu Arg Thr Arg Tyr Glu Gln Ala Asn Cys Asp Cys 
1               5                   10                  15      


Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile His 
            20                  25                  30          


Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile Asp 
        35                  40                  45              


Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly Lys 
    50                  55                  60                  


Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser Ala 
65                  70                  75                  80  


Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu Gln 
                85                  90                  95      


Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg Arg 
            100                 105                 110         


Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln Glu 
        115                 120                 125             


Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro 
    130                 135                 140                 


Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 
145                 150                 155                 160 


Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 
                165                 170                 175     


Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 
            180                 185                 190         


Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 
        195                 200                 205             


Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 
    210                 215                 220                 


Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 
225                 230                 235                 240 


Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 
                245                 250                 255     


Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 
            260                 265                 270         


Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 
        275                 280                 285             


Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 
    290                 295                 300                 


Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 
305                 310                 315                 320 


Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 
                325                 330                 335     


Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 
            340                 345                 350         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 
        355                 360                 365             


Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 
    370                 375                 380                 


Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 
385                 390                 395                 400 


Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
                405                 410                 


<210>  130
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Gly Arg Pro Cys Leu Pro Trp Asn Ser Ala Thr Val Leu Gln Gln 
1               5                   10                  15      


Thr Tyr His Ala His Arg Ser Asp Ala Leu Gln Leu Gly Leu Gly Lys 
            20                  25                  30          


His Asn Tyr Cys Arg Asn Pro Asp Asn Arg Arg Arg Pro Trp Cys Tyr 
        35                  40                  45              


Val Gln Val Gly Leu Lys Pro Leu Val Gln Glu Cys Met Val His Asp 
    50                  55                  60                  


Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro Glu Glu Leu Lys Phe 
65                  70                  75                  80  


Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe Lys Ile Ile Gly Gly 
                85                  90                  95      


Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile Tyr Arg 
            100                 105                 110         


Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser Leu Ile 
        115                 120                 125             


Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp Tyr Pro 
    130                 135                 140                 


Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu Asn Ser 
145                 150                 155                 160 


Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile Leu His 
                165                 170                 175     


Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile Ala Leu 
            180                 185                 190         


Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser Arg Thr 
        195                 200                 205             


Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln Phe Gly 
    210                 215                 220                 


Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr Asp Tyr 
225                 230                 235                 240 


Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile Ser His 
                245                 250                 255     


Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr Thr Lys 
            260                 265                 270         


Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys Gln Gly 
        275                 280                 285             


Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met Thr Leu 
    290                 295                 300                 


Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp Lys Pro 
305                 310                 315                 320 


Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg Ser His 
                325                 330                 335     


Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            340                 345 


<210>  131
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  131

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  132
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  132

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Gly Lys 
385                 390             


<210>  133
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Glu Glu Asp Thr Ala Pro Trp Arg Cys 
                245                 250 


<210>  134
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
        435                 440                 445             


Val Trp Arg Pro Tyr 
    450             


<210>  135
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Ser Asp Ser Ile Phe Glu Ser Phe Pro Ser Tyr Pro Gln Cys 
1               5                   10                  15      


Phe Met Arg Glu Cys Ile Leu Gly Met Asn Pro Ser Arg Asp Val His 
            20                  25                  30          


Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro Ser Thr Ala Leu Ser 
        35                  40                  45              


Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly Ala Pro Asp Ala Gly 
    50                  55                  60                  


Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg Ser Met Val Glu 
65                  70                  75                  80  


Val Leu Ala Asp His Pro Gly Glu Leu Val Arg Thr Asp Ser Pro Asn 
                85                  90                  95      


Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg Cys Asn Lys Thr Leu 
            100                 105                 110         


Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp Val Pro Asp Gly Thr 
        115                 120                 125             


Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu 
    130                 135                 140                 


Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val Ala Arg Phe Asn Asp 
145                 150                 155                 160 


Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr 
                165                 170                 175     


Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala 
            180                 185                 190         


Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln 
        195                 200                 205             


Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser Phe Ser Glu Arg 
    210                 215                 220                 


Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met Arg Val Ser Pro 
225                 230                 235                 240 


His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser Leu Asn His Ser 
                245                 250                 255     


Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln Asp Thr Arg Gln 
            260                 265                 270         


Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Gln Tyr Leu 
        275                 280                 285             


Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr Pro Ile Ser Pro 
    290                 295                 300                 


Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala Glu Leu Ser Ser Arg 
305                 310                 315                 320 


Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser Asp Pro Arg Gln Phe 
                325                 330                 335     


Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met His Tyr Pro Gly Ala 
            340                 345                 350         


Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly Ile Gly Ile Gly Met 
        355                 360                 365             


Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr Tyr Leu Pro Pro Pro 
    370                 375                 380                 


Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro Phe Gln Ala Ser Ser 
385                 390                 395                 400 


Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly Ser Tyr Gln Phe 
                405                 410                 415     


Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile Leu Pro Pro Cys 
            420                 425                 430         


Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn Pro Ser Leu Pro Asn 
        435                 440                 445             


Gln Ser Asp Val Val Glu Ala Glu Gly Ser His Ser Asn Ser Pro Thr 
    450                 455                 460                 


Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala Val Trp Arg Pro Tyr 
465                 470                 475                 480 


<210>  136
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser 
1               5                   10                  15      


Gly Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile 
            20                  25                  30          


Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg Asp 
        35                  40                  45              


Gly Leu Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
    50                  55                  60                  


Glu Met Pro Cys Pro Pro Gly Asn Asp Gly Leu Pro Gly Ala Pro Gly 
65                  70                  75                  80  


Ile Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro 
                85                  90                  95      


Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His 
            100                 105                 110         


Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 
        115                 120                 125             


Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 
    130                 135                 140                 


Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly 
145                 150                 155                 160 


Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 
                165                 170                 175     


Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 
            180                 185                 190         


Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 
        195                 200                 205             


Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 
    210                 215                 220                 


Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr 
225                 230                 235                 240 


Ser Arg Leu Thr Ile Cys Glu Phe 
                245             


<210>  137
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Arg Pro Cys Gln Val Pro Gly Ala Ala Thr Gly Pro Arg Ala Met 
1               5                   10                  15      


Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser Gly 
            20                  25                  30          


Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile Pro 
        35                  40                  45              


Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly 
    50                  55                  60                  


Leu Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu 
65                  70                  75                  80  


Met Pro Cys Pro Pro Gly Asn Asp Gly Leu Pro Gly Ala Pro Gly Ile 
                85                  90                  95      


Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro Pro 
            100                 105                 110         


Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His Asp 
        115                 120                 125             


Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln Gly 
    130                 135                 140                 


Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln Ser 
145                 150                 155                 160 


Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly Arg 
                165                 170                 175     


Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser Phe 
            180                 185                 190         


Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly Pro 
        195                 200                 205             


Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr Thr 
    210                 215                 220                 


Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys Val 
225                 230                 235                 240 


Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr Ser 
                245                 250                 255     


Arg Leu Thr Ile Cys Glu Phe 
            260             


<210>  138
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Arg Pro Cys Gln Val Pro Gly Ala Ala Thr Gly Pro Arg Ala Met 
1               5                   10                  15      


Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser Gly 
            20                  25                  30          


Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Thr Pro Gly Ile Pro 
        35                  40                  45              


Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro Pro Gly 
    50                  55                  60                  


Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His Asp Phe 
65                  70                  75                  80  


Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln Gly Ser 
                85                  90                  95      


Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln Ser Ile 
            100                 105                 110         


Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly Arg Ile 
        115                 120                 125             


Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser Phe Val 
    130                 135                 140                 


Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly Pro Ser 
145                 150                 155                 160 


Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr Thr Asn 
                165                 170                 175     


Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys Val Glu 
            180                 185                 190         


Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr Ser Arg 
        195                 200                 205             


Leu Thr Ile Cys Glu Phe 
    210                 


<210>  139
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser 
1               5                   10                  15      


Gly Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Thr Pro Gly Ile 
            20                  25                  30          


Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro Pro 
        35                  40                  45              


Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His Asp 
    50                  55                  60                  


Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln Gly 
65                  70                  75                  80  


Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln Ser 
                85                  90                  95      


Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly Arg 
            100                 105                 110         


Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser Phe 
        115                 120                 125             


Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly Pro 
    130                 135                 140                 


Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr Thr 
145                 150                 155                 160 


Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys Val 
                165                 170                 175     


Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr Ser 
            180                 185                 190         


Arg Leu Thr Ile Cys Glu Phe 
        195                 


<210>  140
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Trp Leu Cys Pro Leu Ala Leu Thr Leu Ile Leu Met Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile 
            20                  25                  30          


Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg Asp 
        35                  40                  45              


Gly Val Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
    50                  55                  60                  


Glu Thr Pro Cys Pro Pro Gly Asn Asn Gly Leu Pro Gly Ala Pro Gly 
65                  70                  75                  80  


Val Pro Gly Glu Arg Gly Glu Lys Gly Glu Ala Gly Glu Arg Gly Pro 
                85                  90                  95      


Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His 
            100                 105                 110         


Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 
        115                 120                 125             


Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 
    130                 135                 140                 


Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly 
145                 150                 155                 160 


Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 
                165                 170                 175     


Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 
            180                 185                 190         


Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 
        195                 200                 205             


Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 
    210                 215                 220                 


Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr 
225                 230                 235                 240 


Ser Arg Leu Thr Ile Cys Glu Phe 
                245             


<210>  141
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Pro Gly Ala Ala Thr Gly Pro Arg Ala Met Trp Leu Cys Pro Leu 
1               5                   10                  15      


Ala Leu Thr Leu Ile Leu Met Ala Ala Ser Gly Ala Ala Cys Glu Val 
            20                  25                  30          


Lys Asp Val Cys Val Gly Ser Pro Gly Ile Pro Gly Thr Pro Gly Ser 
        35                  40                  45              


His Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Val Lys Gly Asp Pro 
    50                  55                  60                  


Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Thr Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Asn Asn Gly Leu Pro Gly Ala Pro Gly Val Pro Gly Glu Arg Gly 
                85                  90                  95      


Glu Lys Gly Glu Ala Gly Glu Arg Gly Pro Pro Gly Leu Pro Ala His 
            100                 105                 110         


Leu Asp Glu Glu Leu Gln Ala Thr Leu His Asp Phe Arg His Gln Ile 
        115                 120                 125             


Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln Gly Ser Ile Met Thr Val 
    130                 135                 140                 


Gly Glu Lys Val Phe Ser Ser Asn Gly Gln Ser Ile Thr Phe Asp Ala 
145                 150                 155                 160 


Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly Arg Ile Ala Val Pro Arg 
                165                 170                 175     


Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser Phe Val Lys Lys Tyr Asn 
            180                 185                 190         


Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly Pro Ser Pro Gly Asp Phe 
        195                 200                 205             


Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr Thr Asn Trp Tyr Arg Gly 
    210                 215                 220                 


Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys Val Glu Met Tyr Thr Asp 
225                 230                 235                 240 


Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr Ser Arg Leu Thr Ile Cys 
                245                 250                 255     


Glu Phe 
        


<210>  142
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  142

Met His Gln Ala Gly Tyr Pro Gly Cys Arg Gly Ala Met Ala Glu Ser 
1               5                   10                  15      


His Leu Leu Gln Trp Leu Leu Leu Leu Leu Pro Thr Leu Cys Gly Pro 
            20                  25                  30          


Gly Thr Ala Ala Trp Thr Thr Ser Ser Leu Ala Cys Ala Gln Gly Pro 
        35                  40                  45              


Glu Phe Trp Cys Gln Ser Leu Glu Gln Ala Leu Gln Cys Arg Ala Leu 
    50                  55                  60                  


Gly His Cys Leu Gln Glu Val Trp Gly His Val Gly Ala Asp Asp Leu 
65                  70                  75                  80  


Cys Gln Glu Cys Glu Asp Ile Val His Ile Leu Asn Lys Met Ala Lys 
                85                  90                  95      


Glu Ala Ile Phe Gln Asp Thr Met Arg Lys Phe Leu Glu Gln Glu Cys 
            100                 105                 110         


Asn Val Leu Pro Leu Lys Leu Leu Met Pro Gln Cys Asn Gln Val Leu 
        115                 120                 125             


Asp Asp Tyr Phe Pro Leu Val Ile Asp Tyr Phe Gln Asn Gln Thr Asp 
    130                 135                 140                 


Ser Asn Gly Ile Cys Met His Leu Gly Leu Cys Lys Ser Arg Gln Pro 
145                 150                 155                 160 


Glu Pro Glu Gln Glu Pro Gly Met Ser Asp Pro Leu Pro Lys Pro Leu 
                165                 170                 175     


Arg Asp Pro Leu Pro Asp Pro Leu Leu Asp Lys Leu Val Leu Pro Val 
            180                 185                 190         


Leu Pro Gly Ala Leu Gln Ala Arg Pro Gly Pro His Thr Gln Asp Leu 
        195                 200                 205             


Ser Glu Gln Gln Phe Pro Ile Pro Leu Pro Tyr Cys Trp Leu Cys Arg 
    210                 215                 220                 


Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Pro Lys Gly Ala Leu Ala 
225                 230                 235                 240 


Val Ala Val Ala Gln Val Cys Arg Val Val Pro Leu Val Ala Gly Gly 
                245                 250                 255     


Ile Cys Gln Cys Leu Ala Glu Arg Tyr Ser Val Ile Leu Leu Asp Thr 
            260                 265                 270         


Leu Leu Gly Arg Met Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
        275                 280                 285             


Cys Ser Met Asp Asp Ser Ala Gly Pro Arg Ser Pro Thr Gly Glu Trp 
    290                 295                 300                 


Leu Pro Arg Asp Ser Glu Cys His Leu Cys Met Ser Val Thr Thr Gln 
305                 310                 315                 320 


Ala Gly Asn Ser Ser Glu Gln Ala Ile Pro Gln Ala Met Leu Gln Ala 
                325                 330                 335     


Cys Val Gly Ser Trp Leu Asp Arg Glu Lys Cys Lys Gln Phe Val Glu 
            340                 345                 350         


Gln His Thr Pro Gln Leu Leu Thr Leu Val Pro Arg Gly Trp Asp Ala 
        355                 360                 365             


His Thr Thr Cys Gln Ala Leu Gly Val Cys Gly Thr Met Ser Ser Pro 
    370                 375                 380                 


Leu Gln Cys Ile His Ser Pro Asp Leu 
385                 390             


<210>  143
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Asp Val Gly Ser Lys Glu Val Leu Met Glu Ser Pro Pro Asp Tyr 
1               5                   10                  15      


Ser Ala Ala Pro Arg Gly Arg Phe Gly Ile Pro Cys Cys Pro Val His 
            20                  25                  30          


Leu Lys Arg Leu Leu Ile Val Val Val Val Val Val Leu Ile Val Val 
        35                  40                  45              


Val Ile Val Gly Ala Leu Leu Met Gly Leu His Met Ser Gln Lys His 
    50                  55                  60                  


Thr Glu Met Val Leu Glu Met Ser Ile Gly Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Arg Leu Ala Leu Ser Glu His Leu Val Thr Thr Ala Thr Phe Ser Ile 
                85                  90                  95      


Gly Ser Thr Gly Leu Val Val Tyr Asp Tyr Gln Gln Leu Leu Ile Ala 
            100                 105                 110         


Tyr Lys Pro Ala Pro Gly Thr Cys Cys Tyr Ile Met Lys Ile Ala Pro 
        115                 120                 125             


Glu Ser Ile Pro Ser Leu Glu Ala Leu Thr Arg Lys Val His Asn Phe 
    130                 135                 140                 


Gln Met Glu Cys Ser Leu Gln Ala Lys Pro Ala Val Pro Thr Ser Lys 
145                 150                 155                 160 


Leu Gly Gln Ala Glu Gly Arg Asp Ala Gly Ser Ala Pro Ser Gly Gly 
                165                 170                 175     


Asp Pro Ala Phe Leu Gly Met Ala Val Ser Thr Leu Cys Gly Glu Val 
            180                 185                 190         


Pro Leu Tyr Tyr Ile 
        195         


<210>  144
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Asp Val Gly Ser Lys Glu Val Leu Met Glu Ser Pro Pro Asp Tyr 
1               5                   10                  15      


Ser Ala Ala Pro Arg Gly Arg Phe Gly Ile Pro Cys Cys Pro Val His 
            20                  25                  30          


Leu Lys Arg Leu Leu Ile Val Val Val Val Val Val Leu Ile Val Val 
        35                  40                  45              


Val Ile Val Gly Ala Leu Leu Met Gly Leu His Met Ser Gln Lys His 
    50                  55                  60                  


Thr Glu Met Val Leu Glu Met Ser Ile Gly Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Arg Leu Ala Leu Ser Glu His Leu Val Thr Thr Ala Thr Phe Ser Ile 
                85                  90                  95      


Gly Ser Thr Gly Leu Val Val Tyr Asp Tyr Gln Gln Leu Leu Ile Ala 
            100                 105                 110         


Tyr Lys Pro Ala Pro Gly Thr Cys Cys Tyr Ile Met Lys Ile Ala Pro 
        115                 120                 125             


Glu Ser Ile Pro Ser Leu Glu Ala Leu Thr Arg Lys Val His Asn Phe 
    130                 135                 140                 


Gln Ala Lys Pro Ala Val Pro Thr Ser Lys Leu Gly Gln Ala Glu Gly 
145                 150                 155                 160 


Arg Asp Ala Gly Ser Ala Pro Ser Gly Gly Asp Pro Ala Phe Leu Gly 
                165                 170                 175     


Met Ala Val Ser Thr Leu Cys Gly Glu Val Pro Leu Tyr Tyr Ile 
            180                 185                 190     


<210>  145
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Asp Val Gly Ser Lys Glu Val Leu Met Glu Ser Pro Pro Val Leu 
1               5                   10                  15      


Glu Met Ser Ile Gly Ala Pro Glu Ala Gln Gln Arg Leu Ala Leu Ser 
            20                  25                  30          


Glu His Leu Val Thr Thr Ala Thr Phe Ser Ile Gly Ser Thr Gly Leu 
        35                  40                  45              


Val Val Tyr Asp Tyr Gln Gln Leu Leu Ile Ala Tyr Lys Pro Ala Pro 
    50                  55                  60                  


Gly Thr Cys Cys Tyr Ile Met Lys Ile Ala Pro Glu Ser Ile Pro Ser 
65                  70                  75                  80  


Leu Glu Ala Leu Thr Arg Lys Val His Asn Phe Gln Met Glu Cys Ser 
                85                  90                  95      


Leu Gln Ala Lys Pro Ala Val Pro Thr Ser Lys Leu Gly Gln Ala Glu 
            100                 105                 110         


Gly Arg Asp Ala Gly Ser Ala Pro Ser Gly Gly Asp Pro Ala Phe Leu 
        115                 120                 125             


Gly Met Ala Val Ser Thr Leu Cys Gly Glu Val Pro Leu Tyr Tyr Ile 
    130                 135                 140                 


<210>  146
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Leu Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr Gln Pro Leu 
1               5                   10                  15      


Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg Thr Met Pro 
            20                  25                  30          


Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro 
        35                  40                  45              


Gly Arg Asp Gly Arg Asp Gly Arg Glu Gly Pro Arg Gly Glu Lys Gly 
    50                  55                  60                  


Asp Pro Gly Leu Pro Gly Ala Ala Gly Gln Ala Gly Met Pro Gly Gln 
65                  70                  75                  80  


Ala Gly Pro Val Gly Pro Lys Gly Asp Asn Gly Ser Val Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly 
            100                 105                 110         


Val Pro Gly Pro Ala Gly Arg Glu Gly Pro Leu Gly Lys Gln Gly Asn 
        115                 120                 125             


Ile Gly Pro Gln Gly Lys Pro Gly Pro Lys Gly Glu Ala Gly Pro Lys 
    130                 135                 140                 


Gly Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala Gly Ala Arg Gly 
145                 150                 155                 160 


Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly Glu Arg Gly Val 
                165                 170                 175     


Pro Gly Asn Thr Gly Ala Ala Gly Ser Ala Gly Ala Met Gly Pro Gln 
            180                 185                 190         


Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly Leu Lys Gly Asp Lys Gly 
        195                 200                 205             


Ile Pro Gly Asp Lys Gly Ala Lys Gly Glu Ser Gly Leu Pro Asp Val 
    210                 215                 220                 


Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln His 
225                 230                 235                 240 


Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro Asn 
                245                 250                 255     


Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val Lys 
            260                 265                 270         


Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln Leu 
        275                 280                 285             


Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu Val 
    290                 295                 300                 


Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys Thr 
305                 310                 315                 320 


Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser Asn 
                325                 330                 335     


Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys Val 
            340                 345                 350         


Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu Lys 
        355                 360                 365             


Arg Leu Val Val Cys Glu Phe 
    370                 375 


<210>  147
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Glu Gln Gln Asp Gln Ser Met Lys Glu Gly Arg Leu Thr Leu Val 
1               5                   10                  15      


Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly Ser Ser Phe Gln Tyr 
            20                  25                  30          


Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala Leu Leu Met Gln Gln 
        35                  40                  45              


Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly Glu Phe Met Glu Asp 
    50                  55                  60                  


Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser Met Phe Pro Phe 
65                  70                  75                  80  


Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu Val Asn Lys Phe 
                85                  90                  95      


Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe Ser Ile Val Pro 
            100                 105                 110         


Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser Phe Glu Leu Ile 
        115                 120                 125             


Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly Val Ser Ser Asn 
    130                 135                 140                 


Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly 
145                 150                 155                 160 


Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val 
                165                 170                 175     


Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Trp 
            180                 185                 190         


Pro Ile Leu Leu Gly Leu Thr Gly Val Pro Ala Ala Leu Gln Leu Leu 
        195                 200                 205             


Leu Leu Pro Phe Phe Pro Glu Ser Pro Arg Tyr Leu Leu Ile Gln Lys 
    210                 215                 220                 


Lys Asp Glu Ala Ala Ala Lys Lys Ala Leu Gln Thr Leu Arg Gly Trp 
225                 230                 235                 240 


Asp Ser Val Asp Arg Glu Val Ala Glu Ile Arg Gln Glu Asp Glu Ala 
                245                 250                 255     


Glu Lys Ala Ala Gly Phe Ile Ser Val Leu Lys Leu Phe Arg Met Arg 
            260                 265                 270         


Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile Val Leu Met Gly Gly Gln 
        275                 280                 285             


Gln Leu Ser Gly Val Asn Ala Ile Tyr Tyr Tyr Ala Asp Gln Ile Tyr 
    290                 295                 300                 


Leu Ser Ala Gly Val Pro Glu Glu His Val Gln Tyr Val Thr Ala Gly 
305                 310                 315                 320 


Thr Gly Ala Val Asn Val Val Met Thr Phe Cys Ala Val Phe Val Val 
                325                 330                 335     


Glu Leu Leu Gly Arg Arg Leu Leu Leu Leu Leu Gly Phe Ser Ile Cys 
            340                 345                 350         


Leu Ile Ala Cys Cys Val Leu Thr Ala Ala Leu Ala Leu Gln Asp Thr 
        355                 360                 365             


Val Ser Trp Met Pro Tyr Ile Ser Ile Val Cys Val Ile Ser Tyr Val 
    370                 375                 380                 


Ile Gly His Ala Leu Gly Pro Ser Pro Ile Pro Ala Leu Leu Ile Thr 
385                 390                 395                 400 


Glu Ile Phe Leu Gln Ser Ser Arg Pro Ser Ala Phe Met Val Gly Gly 
                405                 410                 415     


Ser Val His Trp Leu Ser Asn Phe Thr Val Gly Leu Ile Phe Pro Phe 
            420                 425                 430         


Ile Gln Glu Gly Leu Gly Pro Tyr Ser Phe Ile Val Phe Ala Val Ile 
        435                 440                 445             


Cys Leu Leu Thr Thr Ile Tyr Ile Phe Leu Ile Val Pro Glu Thr Lys 
    450                 455                 460                 


Ala Lys Thr Phe Ile Glu Ile Asn Gln Ile Phe Thr Lys Met Asn Lys 
465                 470                 475                 480 


Val Ser Glu Val Tyr Pro Glu Lys Glu Glu Leu Lys Glu Leu Pro Pro 
                485                 490                 495     


Val Thr Ser Glu Gln 
            500     


<210>  148
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Glu Gln Gln Asp Gln Ser Met Lys Glu Gly Arg Leu Thr Leu Val 
1               5                   10                  15      


Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly Ser Ser Phe Gln Tyr 
            20                  25                  30          


Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala Leu Leu Met Gln Gln 
        35                  40                  45              


Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly Glu Phe Met Glu Asp 
    50                  55                  60                  


Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser Met Phe Pro Phe 
65                  70                  75                  80  


Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu Val Asn Lys Phe 
                85                  90                  95      


Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe Ser Ile Val Pro 
            100                 105                 110         


Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser Phe Glu Leu Ile 
        115                 120                 125             


Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly Val Ser Ser Asn 
    130                 135                 140                 


Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly 
145                 150                 155                 160 


Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val 
                165                 170                 175     


Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Glu 
            180                 185                 190         


Phe Arg Thr Ser Arg Glu His Pro His Pro Phe Thr Thr Thr Leu Gly 
        195                 200                 205             


Pro Leu Leu Val Phe Gln Ser His His His Arg Thr Gly Leu Ser Ala 
    210                 215                 220                 


Asp Trp Ser Leu Leu Thr Gly Trp Met Ser Leu Gly Gly Pro Ser Cys 
225                 230                 235                 240 


Pro Glu Pro Thr 
                


<210>  149
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Gly Thr Thr Trp Leu Leu Ser Thr Pro Gln His Trp Thr Gly Glu 
1               5                   10                  15      


Phe Met Glu Asp Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val Ser 
            20                  25                  30          


Met Phe Pro Phe Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro Leu 
        35                  40                  45              


Val Asn Lys Phe Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile Phe 
    50                  55                  60                  


Ser Ile Val Pro Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr Ser 
65                  70                  75                  80  


Phe Glu Leu Ile Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala Gly 
                85                  90                  95      


Val Ser Ser Asn Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro Lys 
            100                 105                 110         


Asn Leu Arg Gly Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr Val 
        115                 120                 125             


Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala Asn 
    130                 135                 140                 


Val Asp Gly Trp Pro Ile Leu Leu Gly Leu Thr Gly Val Pro Ala Ala 
145                 150                 155                 160 


Leu Gln Leu Leu Leu Leu Pro Phe Phe Pro Glu Ser Pro Arg Tyr Leu 
                165                 170                 175     


Leu Ile Gln Lys Lys Asp Glu Ala Ala Ala Lys Lys Ala Leu Gln Thr 
            180                 185                 190         


Leu Arg Gly Trp Asp Ser Val Asp Arg Glu Val Ala Glu Ile Arg Gln 
        195                 200                 205             


Glu Asp Glu Ala Glu Lys Ala Ala Gly Phe Ile Ser Val Leu Lys Leu 
    210                 215                 220                 


Phe Arg Met Arg Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile Val Leu 
225                 230                 235                 240 


Met Gly Gly Gln Gln Leu Ser Gly Val Asn Ala Ile Tyr Tyr Tyr Ala 
                245                 250                 255     


Asp Gln Ile Tyr Leu Ser Ala Gly Val Pro Glu Glu His Val Gln Tyr 
            260                 265                 270         


Val Thr Ala Gly Thr Gly Ala Val Asn Val Val Met Thr Phe Cys Ala 
        275                 280                 285             


Val Phe Val Val Glu Leu Leu Gly Arg Arg Leu Leu Leu Leu Leu Gly 
    290                 295                 300                 


Phe Ser Ile Cys Leu Ile Ala Cys Cys Val Leu Thr Ala Ala Leu Ala 
305                 310                 315                 320 


Leu Gln Asp Thr Val Ser Trp Met Pro Tyr Ile Ser Ile Val Cys Val 
                325                 330                 335     


Ile Ser Tyr Val Ile Gly His Ala Leu Gly Pro Ser Pro Ile Pro Ala 
            340                 345                 350         


Leu Leu Ile Thr Glu Ile Phe Leu Gln Ser Ser Arg Pro Ser Ala Phe 
        355                 360                 365             


Met Val Gly Gly Ser Val His Trp Leu Ser Asn Phe Thr Val Gly Leu 
    370                 375                 380                 


Ile Phe Pro Phe Ile Gln Glu Gly Leu Gly Pro Tyr Ser Phe Ile Val 
385                 390                 395                 400 


Phe Ala Val Ile Cys Leu Leu Thr Thr Ile Tyr Ile Phe Leu Ile Val 
                405                 410                 415     


Pro Glu Thr Lys Ala Lys Thr Phe Ile Glu Ile Asn Gln Ile Phe Thr 
            420                 425                 430         


Lys Met Asn Lys Val Ser Glu Val Tyr Pro Glu Lys Glu Glu Leu Lys 
        435                 440                 445             


Glu Leu Pro Pro Val Thr Ser Glu Gln 
    450                 455         


<210>  150
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Tyr Leu Gly Glu Leu Ala Pro Lys Asn Leu Arg Gly Ala Leu Gly 
1               5                   10                  15      


Val Val Pro Gln Leu Phe Ile Thr Val Gly Ile Leu Val Ala Gln Ile 
            20                  25                  30          


Phe Gly Leu Arg Asn Leu Leu Ala Asn Val Asp Gly Trp Pro Ile Leu 
        35                  40                  45              


Leu Gly Leu Thr Gly Val Pro Ala Ala Leu Gln Leu Leu Leu Leu Pro 
    50                  55                  60                  


Phe Phe Pro Glu Ser Pro Arg Tyr Leu Leu Ile Gln Lys Lys Asp Glu 
65                  70                  75                  80  


Ala Ala Ala Lys Lys Ala Leu Gln Thr Leu Arg Gly Trp Asp Ser Val 
                85                  90                  95      


Asp Arg Glu Val Ala Glu Ile Arg Gln Glu Asp Glu Ala Glu Lys Ala 
            100                 105                 110         


Ala Gly Phe Ile Ser Val Leu Lys Leu Phe Arg Met Arg Ser Leu Arg 
        115                 120                 125             


Trp Gln Leu Leu Ser Ile Ile Val Leu Met Gly Gly Gln Gln Leu Ser 
    130                 135                 140                 


Gly Val Asn Ala Ile Tyr Tyr Tyr Ala Asp Gln Ile Tyr Leu Ser Ala 
145                 150                 155                 160 


Gly Val Pro Glu Glu His Val Gln Tyr Val Thr Ala Gly Thr Gly Ala 
                165                 170                 175     


Val Asn Val Val Met Thr Phe Cys Ala Val Phe Val Val Glu Leu Leu 
            180                 185                 190         


Gly Arg Arg Leu Leu Leu Leu Leu Gly Phe Ser Ile Cys Leu Ile Ala 
        195                 200                 205             


Cys Cys Val Leu Thr Ala Ala Leu Ala Leu Gln Asp Thr Val Ser Trp 
    210                 215                 220                 


Met Pro Tyr Ile Ser Ile Val Cys Val Ile Ser Tyr Val Ile Gly His 
225                 230                 235                 240 


Ala Leu Gly Pro Ser Pro Ile Pro Ala Leu Leu Ile Thr Glu Ile Phe 
                245                 250                 255     


Leu Gln Ser Ser Arg Pro Ser Ala Phe Met Val Gly Gly Ser Val His 
            260                 265                 270         


Trp Leu Ser Asn Phe Thr Val Gly Leu Ile Phe Pro Phe Ile Gln Glu 
        275                 280                 285             


Gly Leu Gly Pro Tyr Ser Phe Ile Val Phe Ala Val Ile Cys Leu Leu 
    290                 295                 300                 


Thr Thr Ile Tyr Ile Phe Leu Ile Val Pro Glu Thr Lys Ala Lys Thr 
305                 310                 315                 320 


Phe Ile Glu Ile Asn Gln Ile Phe Thr Lys Met Asn Lys Val Ser Glu 
                325                 330                 335     


Val Tyr Pro Glu Lys Glu Glu Leu Lys Glu Leu Pro Pro Val Thr Ser 
            340                 345                 350         


Glu Gln 
        


<210>  151
<211>  1321
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Glu Leu Glu Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser 
1               5                   10                  15      


Gly Ala Val Met Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr 
            20                  25                  30          


Arg Glu Phe Glu Arg Leu Ile Gly Arg Tyr Asp Glu Glu Val Val Lys 
        35                  40                  45              


Glu Leu Met Pro Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val 
    50                  55                  60                  


Phe Ala Gln Asp Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp 
65                  70                  75                  80  


Asp Asn Glu Gln Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg 
                85                  90                  95      


Lys His Ala Glu Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln 
            100                 105                 110         


Glu Lys Lys Asp Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr 
        115                 120                 125             


Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Arg 
    130                 135                 140                 


Leu Glu Glu Arg Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His 
145                 150                 155                 160 


Gln Arg His Thr Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg 
                165                 170                 175     


Thr Lys Leu His Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala 
            180                 185                 190         


His Ser Arg Ile Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro 
        195                 200                 205             


Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly 
    210                 215                 220                 


Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro 
225                 230                 235                 240 


Arg Ser His Thr Ser Leu Lys Val Ser Asn Ser Pro Glu Pro Gln Lys 
                245                 250                 255     


Ala Val Glu Gln Glu Asp Glu Leu Ser Asp Val Ser Gln Gly Gly Ser 
            260                 265                 270         


Lys Ala Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala Thr Ile 
        275                 280                 285             


Pro Thr Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val Lys Val 
    290                 295                 300                 


Thr Asp Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu Val Gln 
305                 310                 315                 320 


Val Ala Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu Asn Glu 
                325                 330                 335     


Glu Lys Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu Leu Asp 
            340                 345                 350         


Met Asp Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro Thr Lys 
        355                 360                 365             


Gly Ile Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu Phe Glu 
    370                 375                 380                 


Glu Leu Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp Glu Gly 
385                 390                 395                 400 


Ala Asp Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile Leu Glu 
                405                 410                 415     


Asn Thr Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val Lys Asn 
            420                 425                 430         


Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp Val Leu 
        435                 440                 445             


Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu Glu Glu 
    450                 455                 460                 


Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala Glu Ala 
465                 470                 475                 480 


Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp Ile Pro 
                485                 490                 495     


Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg Val Leu 
            500                 505                 510         


Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln Glu Ala 
        515                 520                 525             


Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro Ala Met 
    530                 535                 540                 


Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg Leu Phe 
545                 550                 555                 560 


Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val Asn Leu 
                565                 570                 575     


Lys Tyr Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys Lys Arg 
            580                 585                 590         


Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala Phe Asp 
        595                 600                 605             


Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg Glu Gln 
    610                 615                 620                 


Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys Glu Asp 
625                 630                 635                 640 


Gly Arg Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr Lys Gln 
                645                 650                 655     


Val Thr Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro Val Pro 
            660                 665                 670         


Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp Thr Ser Met Lys Leu Trp 
        675                 680                 685             


Cys Ala Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp Gly Gly 
    690                 695                 700                 


Ser Val Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly Leu Asp 
705                 710                 715                 720 


Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu Asp Lys 
                725                 730                 735     


Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn Gln Glu 
            740                 745                 750         


Glu Leu Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser Ala Thr 
        755                 760                 765             


Lys Val Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu Asp Ser 
    770                 775                 780                 


Phe Thr Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val Pro Gly 
785                 790                 795                 800 


Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu Ser Gly 
                805                 810                 815     


Gln Val Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn Ser Ser 
            820                 825                 830         


Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly Cys Ser 
        835                 840                 845             


Ala Glu Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn Gly Ala 
    850                 855                 860                 


Ser Pro Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn Ser Glu 
865                 870                 875                 880 


Val Asp Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala Thr Glu 
                885                 890                 895     


Gly Asn Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln Thr Gly 
            900                 905                 910         


Val Tyr Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln Ile Pro 
        915                 920                 925             


Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp Ala Tyr 
    930                 935                 940                 


Lys Asp Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val Arg Glu 
945                 950                 955                 960 


Glu Ala Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu Gly Ala 
                965                 970                 975     


Gln Asn Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp Arg Lys 
            980                 985                 990         


Cys Leu His Ser Ile Lys Leu Lys  Asp Ser Ile Leu Ser  Ile Val His 
        995                 1000                 1005             


Val Lys  Gly Ile Val Leu Val  Ala Leu Ala Asp Gly  Thr Leu Ala 
    1010                 1015                 1020             


Ile Phe  His Arg Gly Val Asp  Gly Gln Trp Asp Leu  Ser Asn Tyr 
    1025                 1030                 1035             


His Leu  Leu Asp Leu Gly Arg  Pro His His Ser Ile  Arg Cys Met 
    1040                 1045                 1050             


Thr Val  Val His Asp Lys Val  Trp Cys Gly Tyr Arg  Asn Lys Ile 
    1055                 1060                 1065             


Tyr Val  Val Gln Pro Lys Ala  Met Lys Ile Glu Lys  Ser Phe Asp 
    1070                 1075                 1080             


Ala His  Pro Arg Lys Glu Ser  Gln Val Arg Gln Leu  Ala Trp Val 
    1085                 1090                 1095             


Gly Asp  Gly Val Trp Val Ser  Ile Arg Leu Asp Ser  Thr Leu Arg 
    1100                 1105                 1110             


Leu Tyr  His Ala His Thr Tyr  Gln His Leu Gln Asp  Val Asp Ile 
    1115                 1120                 1125             


Glu Pro  Tyr Val Ser Lys Met  Leu Gly Thr Gly Lys  Leu Gly Phe 
    1130                 1135                 1140             


Ser Phe  Val Arg Ile Thr Ala  Leu Met Val Ser Cys  Asn Arg Leu 
    1145                 1150                 1155             


Trp Val  Gly Thr Gly Asn Gly  Val Ile Ile Ser Ile  Pro Leu Thr 
    1160                 1165                 1170             


Glu Thr  Asn Lys Thr Ser Gly  Val Pro Gly Asn Arg  Pro Gly Ser 
    1175                 1180                 1185             


Val Ile  Arg Val Tyr Gly Asp  Glu Asn Ser Asp Lys  Val Thr Pro 
    1190                 1195                 1200             


Gly Thr  Phe Ile Pro Tyr Cys  Ser Met Ala His Ala  Gln Leu Cys 
    1205                 1210                 1215             


Phe His  Gly His Arg Asp Ala  Val Lys Phe Phe Val  Ala Val Pro 
    1220                 1225                 1230             


Gly Gln  Val Ile Ser Pro Gln  Ser Ser Ser Ser Gly  Thr Asp Leu 
    1235                 1240                 1245             


Thr Gly  Asp Lys Ala Gly Pro  Ser Ala Gln Glu Pro  Gly Ser Gln 
    1250                 1255                 1260             


Thr Pro  Leu Lys Ser Met Leu  Val Ile Ser Gly Gly  Glu Gly Tyr 
    1265                 1270                 1275             


Ile Asp  Phe Arg Met Gly Asp  Glu Gly Gly Glu Ser  Glu Leu Leu 
    1280                 1285                 1290             


Gly Glu  Asp Leu Pro Leu Glu  Pro Ser Val Thr Lys  Ala Glu Arg 
    1295                 1300                 1305             


Ser His  Leu Ile Val Trp Gln  Val Met Tyr Gly Asn  Glu 
    1310                 1315                 1320     


<210>  152
<211>  1311
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Glu Leu Glu Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser 
1               5                   10                  15      


Gly Ala Val Met Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr 
            20                  25                  30          


Arg Glu Phe Glu Arg Leu Ile Gly Arg Tyr Asp Glu Glu Val Val Lys 
        35                  40                  45              


Glu Leu Met Pro Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val 
    50                  55                  60                  


Phe Ala Gln Asp Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp 
65                  70                  75                  80  


Asp Asn Glu Gln Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg 
                85                  90                  95      


Lys His Ala Glu Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln 
            100                 105                 110         


Glu Lys Lys Asp Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr 
        115                 120                 125             


Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Arg 
    130                 135                 140                 


Leu Glu Glu Arg Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His 
145                 150                 155                 160 


Gln Arg His Thr Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg 
                165                 170                 175     


Thr Lys Leu His Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala 
            180                 185                 190         


His Ser Arg Ile Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro 
        195                 200                 205             


Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly 
    210                 215                 220                 


Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro 
225                 230                 235                 240 


Arg Ser His Thr Ser Leu Lys Asp Glu Leu Ser Asp Val Ser Gln Gly 
                245                 250                 255     


Gly Ser Lys Ala Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala 
            260                 265                 270         


Thr Ile Pro Thr Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val 
        275                 280                 285             


Lys Val Thr Asp Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu 
    290                 295                 300                 


Val Gln Val Ala Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu 
305                 310                 315                 320 


Asn Glu Glu Lys Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu 
                325                 330                 335     


Leu Asp Met Asp Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro 
            340                 345                 350         


Thr Lys Gly Ile Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu 
        355                 360                 365             


Phe Glu Glu Leu Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp 
    370                 375                 380                 


Glu Gly Ala Asp Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile 
385                 390                 395                 400 


Leu Glu Asn Thr Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val 
                405                 410                 415     


Lys Asn Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp 
            420                 425                 430         


Val Leu Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu 
        435                 440                 445             


Glu Glu Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala 
    450                 455                 460                 


Glu Ala Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp 
465                 470                 475                 480 


Ile Pro Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg 
                485                 490                 495     


Val Leu Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln 
            500                 505                 510         


Glu Ala Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro 
        515                 520                 525             


Ala Met Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Val Pro Thr 
    530                 535                 540                 


Arg Phe Ser Arg Leu Phe Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro 
545                 550                 555                 560 


Glu Pro Pro Val Asn Leu Lys Tyr Asn Ala Pro Thr Ser His Val Thr 
                565                 570                 575     


Pro Ser Val Lys Lys Arg Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp 
            580                 585                 590         


Lys Ser Lys Ala Phe Asp Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu 
        595                 600                 605             


Ala Ser Arg Arg Glu Gln Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala 
    610                 615                 620                 


His Val Gln Lys Glu Asp Gly Arg Val Gln Ala Phe Gly Trp Ser Leu 
625                 630                 635                 640 


Pro Gln Lys Tyr Lys Gln Val Thr Asn Gly Gln Gly Glu Asn Lys Met 
                645                 650                 655     


Lys Asn Leu Pro Val Pro Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp 
            660                 665                 670         


Thr Ser Met Lys Leu Trp Cys Ala Val Gly Val Asn Leu Ser Gly Gly 
        675                 680                 685             


Lys Thr Arg Asp Gly Gly Ser Val Val Gly Ala Ser Val Phe Tyr Lys 
    690                 695                 700                 


Asp Val Ala Gly Leu Asp Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser 
705                 710                 715                 720 


Gln Ser Ser Leu Asp Lys Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys 
                725                 730                 735     


Glu Leu Lys Asn Gln Glu Glu Leu Ser Ser Leu Val Trp Ile Cys Thr 
            740                 745                 750         


Ser Thr His Ser Ala Thr Lys Val Leu Ile Ile Asp Ala Val Gln Pro 
        755                 760                 765             


Gly Asn Ile Leu Asp Ser Phe Thr Val Cys Asn Ser His Val Leu Cys 
    770                 775                 780                 


Ile Ala Ser Val Pro Gly Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu 
785                 790                 795                 800 


Asp Leu Ser Glu Ser Gly Gln Val Asp Lys Ala Ser Leu Cys Gly Ser 
                805                 810                 815     


Met Thr Ser Asn Ser Ser Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile 
            820                 825                 830         


Thr Val Val Gly Cys Ser Ala Glu Gly Val Thr Gly Ala Ala Thr Ser 
        835                 840                 845             


Pro Ser Thr Asn Gly Ala Ser Pro Val Met Asp Lys Pro Pro Glu Met 
    850                 855                 860                 


Glu Ala Glu Asn Ser Glu Val Asp Glu Asn Val Pro Thr Ala Glu Glu 
865                 870                 875                 880 


Ala Thr Glu Ala Thr Glu Gly Asn Ala Gly Ser Ala Glu Asp Thr Val 
                885                 890                 895     


Asp Ile Ser Gln Thr Gly Val Tyr Thr Glu His Val Phe Thr Asp Pro 
            900                 905                 910         


Leu Gly Val Gln Ile Pro Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser 
        915                 920                 925             


Asn Asp Ser Asp Ala Tyr Lys Asp Gln Ile Ser Val Leu Pro Asn Glu 
    930                 935                 940                 


Gln Asp Leu Val Arg Glu Glu Ala Gln Lys Met Ser Ser Leu Leu Pro 
945                 950                 955                 960 


Thr Met Trp Leu Gly Ala Gln Asn Gly Cys Leu Tyr Val His Ser Ser 
                965                 970                 975     


Val Ala Gln Trp Arg Lys Cys Leu His Ser Ile Lys Leu Lys Asp Ser 
            980                 985                 990         


Ile Leu Ser Ile Val His Val Lys  Gly Ile Val Leu Val  Ala Leu Ala 
        995                 1000                 1005             


Asp Gly  Thr Leu Ala Ile Phe  His Arg Gly Val Asp  Gly Gln Trp 
    1010                 1015                 1020             


Asp Leu  Ser Asn Tyr His Leu  Leu Asp Leu Gly Arg  Pro His His 
    1025                 1030                 1035             


Ser Ile  Arg Cys Met Thr Val  Val His Asp Lys Val  Trp Cys Gly 
    1040                 1045                 1050             


Tyr Arg  Asn Lys Ile Tyr Val  Val Gln Pro Lys Ala  Met Lys Ile 
    1055                 1060                 1065             


Glu Lys  Ser Phe Asp Ala His  Pro Arg Lys Glu Ser  Gln Val Arg 
    1070                 1075                 1080             


Gln Leu  Ala Trp Val Gly Asp  Gly Val Trp Val Ser  Ile Arg Leu 
    1085                 1090                 1095             


Asp Ser  Thr Leu Arg Leu Tyr  His Ala His Thr Tyr  Gln His Leu 
    1100                 1105                 1110             


Gln Asp  Val Asp Ile Glu Pro  Tyr Val Ser Lys Met  Leu Gly Thr 
    1115                 1120                 1125             


Gly Lys  Leu Gly Phe Ser Phe  Val Arg Ile Thr Ala  Leu Met Val 
    1130                 1135                 1140             


Ser Cys  Asn Arg Leu Trp Val  Gly Thr Gly Asn Gly  Val Ile Ile 
    1145                 1150                 1155             


Ser Ile  Pro Leu Thr Glu Thr  Asn Lys Thr Ser Gly  Val Pro Gly 
    1160                 1165                 1170             


Asn Arg  Pro Gly Ser Val Ile  Arg Val Tyr Gly Asp  Glu Asn Ser 
    1175                 1180                 1185             


Asp Lys  Val Thr Pro Gly Thr  Phe Ile Pro Tyr Cys  Ser Met Ala 
    1190                 1195                 1200             


His Ala  Gln Leu Cys Phe His  Gly His Arg Asp Ala  Val Lys Phe 
    1205                 1210                 1215             


Phe Val  Ala Val Pro Gly Gln  Val Ile Ser Pro Gln  Ser Ser Ser 
    1220                 1225                 1230             


Ser Gly  Thr Asp Leu Thr Gly  Asp Lys Ala Gly Pro  Ser Ala Gln 
    1235                 1240                 1245             


Glu Pro  Gly Ser Gln Thr Pro  Leu Lys Ser Met Leu  Val Ile Ser 
    1250                 1255                 1260             


Gly Gly  Glu Gly Tyr Ile Asp  Phe Arg Met Gly Asp  Glu Gly Gly 
    1265                 1270                 1275             


Glu Ser  Glu Leu Leu Gly Glu  Asp Leu Pro Leu Glu  Pro Ser Val 
    1280                 1285                 1290             


Thr Lys  Ala Glu Arg Ser His  Leu Ile Val Trp Gln  Val Met Tyr 
    1295                 1300                 1305             


Gly Asn  Glu 
    1310     


<210>  153
<211>  1307
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Glu Leu Glu Asp Gly Val Val Tyr Gln Glu Glu Pro Gly Gly Ser 
1               5                   10                  15      


Gly Ala Val Met Ser Glu Arg Val Ser Gly Leu Ala Gly Ser Ile Tyr 
            20                  25                  30          


Arg Glu Phe Glu Arg Leu Ile Gly Arg Tyr Asp Glu Glu Val Val Lys 
        35                  40                  45              


Glu Leu Met Pro Leu Val Val Ala Val Leu Glu Asn Leu Asp Ser Val 
    50                  55                  60                  


Phe Ala Gln Asp Gln Glu His Gln Val Glu Leu Glu Leu Leu Arg Asp 
65                  70                  75                  80  


Asp Asn Glu Gln Leu Ile Thr Gln Tyr Glu Arg Glu Lys Ala Leu Arg 
                85                  90                  95      


Lys His Ala Glu Glu Lys Phe Ile Glu Phe Glu Asp Ser Gln Glu Gln 
            100                 105                 110         


Glu Lys Lys Asp Leu Gln Thr Arg Val Glu Ser Leu Glu Ser Gln Thr 
        115                 120                 125             


Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala Asp Gln Ile Ser Arg 
    130                 135                 140                 


Leu Glu Glu Arg Glu Ala Glu Leu Lys Lys Glu Tyr Asn Ala Leu His 
145                 150                 155                 160 


Gln Arg His Thr Glu Met Ile His Asn Tyr Met Glu His Leu Glu Arg 
                165                 170                 175     


Thr Lys Leu His Gln Leu Ser Gly Ser Asp Gln Leu Glu Ser Thr Ala 
            180                 185                 190         


His Ser Arg Ile Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe Pro 
        195                 200                 205             


Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly Gly 
    210                 215                 220                 


Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln Pro 
225                 230                 235                 240 


Arg Ser His Thr Ser Leu Lys Asp Glu Leu Ser Asp Val Ser Gln Gly 
                245                 250                 255     


Gly Ser Lys Ala Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val Ala 
            260                 265                 270         


Thr Ile Pro Thr Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe Val 
        275                 280                 285             


Lys Val Thr Asp Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile Glu 
    290                 295                 300                 


Val Gln Val Ala Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala Glu 
305                 310                 315                 320 


Asn Glu Glu Lys Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro Glu 
                325                 330                 335     


Leu Asp Met Asp Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr Pro 
            340                 345                 350         


Thr Lys Gly Ile Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser Leu 
        355                 360                 365             


Phe Glu Glu Leu Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val Asp 
    370                 375                 380                 


Glu Gly Ala Asp Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu Ile 
385                 390                 395                 400 


Leu Glu Asn Thr Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile Val 
                405                 410                 415     


Lys Asn Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys Asp 
            420                 425                 430         


Val Leu Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys Leu 
        435                 440                 445             


Glu Glu Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg Ala 
    450                 455                 460                 


Glu Ala Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser Asp 
465                 470                 475                 480 


Ile Pro Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala Arg 
                485                 490                 495     


Val Leu Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu Gln 
            500                 505                 510         


Glu Ala Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn Pro 
        515                 520                 525             


Ala Met Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser Arg 
    530                 535                 540                 


Leu Phe Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro Val 
545                 550                 555                 560 


Asn Leu Lys Tyr Asn Ala Pro Thr Ser His Val Thr Pro Ser Val Lys 
                565                 570                 575     


Lys Arg Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys Ala 
            580                 585                 590         


Phe Asp Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg Arg 
        595                 600                 605             


Glu Gln Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln Lys 
    610                 615                 620                 


Glu Asp Gly Arg Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys Tyr 
625                 630                 635                 640 


Lys Gln Val Thr Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu Pro 
                645                 650                 655     


Val Pro Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp Thr Ser Met Lys 
            660                 665                 670         


Leu Trp Cys Ala Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg Asp 
        675                 680                 685             


Gly Gly Ser Val Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala Gly 
    690                 695                 700                 


Leu Asp Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser Leu 
705                 710                 715                 720 


Asp Lys Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys Asn 
                725                 730                 735     


Gln Glu Glu Leu Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His Ser 
            740                 745                 750         


Ala Thr Lys Val Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile Leu 
        755                 760                 765             


Asp Ser Phe Thr Val Cys Asn Ser His Val Leu Cys Ile Ala Ser Val 
    770                 775                 780                 


Pro Gly Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser Glu 
785                 790                 795                 800 


Ser Gly Gln Val Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser Asn 
                805                 810                 815     


Ser Ser Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val Gly 
            820                 825                 830         


Cys Ser Ala Glu Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr Asn 
        835                 840                 845             


Gly Ala Ser Pro Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu Asn 
    850                 855                 860                 


Ser Glu Val Asp Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu Ala 
865                 870                 875                 880 


Thr Glu Gly Asn Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser Gln 
                885                 890                 895     


Thr Gly Val Tyr Thr Glu His Val Phe Thr Asp Pro Leu Gly Val Gln 
            900                 905                 910         


Ile Pro Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser Asp 
        915                 920                 925             


Ala Tyr Lys Asp Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu Val 
    930                 935                 940                 


Arg Glu Glu Ala Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp Leu 
945                 950                 955                 960 


Gly Ala Gln Asn Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln Trp 
                965                 970                 975     


Arg Lys Cys Leu His Ser Ile Lys Leu Lys Asp Ser Ile Leu Ser Ile 
            980                 985                 990         


Val His Val Lys Gly Ile Val Leu  Val Ala Leu Ala Asp  Gly Thr Leu 
        995                 1000                 1005             


Ala Ile  Phe His Arg Gly Val  Asp Gly Gln Trp Asp  Leu Ser Asn 
    1010                 1015                 1020             


Tyr His  Leu Leu Asp Leu Gly  Arg Pro His His Ser  Ile Arg Cys 
    1025                 1030                 1035             


Met Thr  Val Val His Asp Lys  Val Trp Cys Gly Tyr  Arg Asn Lys 
    1040                 1045                 1050             


Ile Tyr  Val Val Gln Pro Lys  Ala Met Lys Ile Glu  Lys Ser Phe 
    1055                 1060                 1065             


Asp Ala  His Pro Arg Lys Glu  Ser Gln Val Arg Gln  Leu Ala Trp 
    1070                 1075                 1080             


Val Gly  Asp Gly Val Trp Val  Ser Ile Arg Leu Asp  Ser Thr Leu 
    1085                 1090                 1095             


Arg Leu  Tyr His Ala His Thr  Tyr Gln His Leu Gln  Asp Val Asp 
    1100                 1105                 1110             


Ile Glu  Pro Tyr Val Ser Lys  Met Leu Gly Thr Gly  Lys Leu Gly 
    1115                 1120                 1125             


Phe Ser  Phe Val Arg Ile Thr  Ala Leu Met Val Ser  Cys Asn Arg 
    1130                 1135                 1140             


Leu Trp  Val Gly Thr Gly Asn  Gly Val Ile Ile Ser  Ile Pro Leu 
    1145                 1150                 1155             


Thr Glu  Thr Asn Lys Thr Ser  Gly Val Pro Gly Asn  Arg Pro Gly 
    1160                 1165                 1170             


Ser Val  Ile Arg Val Tyr Gly  Asp Glu Asn Ser Asp  Lys Val Thr 
    1175                 1180                 1185             


Pro Gly  Thr Phe Ile Pro Tyr  Cys Ser Met Ala His  Ala Gln Leu 
    1190                 1195                 1200             


Cys Phe  His Gly His Arg Asp  Ala Val Lys Phe Phe  Val Ala Val 
    1205                 1210                 1215             


Pro Gly  Gln Val Ile Ser Pro  Gln Ser Ser Ser Ser  Gly Thr Asp 
    1220                 1225                 1230             


Leu Thr  Gly Asp Lys Ala Gly  Pro Ser Ala Gln Glu  Pro Gly Ser 
    1235                 1240                 1245             


Gln Thr  Pro Leu Lys Ser Met  Leu Val Ile Ser Gly  Gly Glu Gly 
    1250                 1255                 1260             


Tyr Ile  Asp Phe Arg Met Gly  Asp Glu Gly Gly Glu  Ser Glu Leu 
    1265                 1270                 1275             


Leu Gly  Glu Asp Leu Pro Leu  Glu Pro Ser Val Thr  Lys Ala Glu 
    1280                 1285                 1290             


Arg Ser  His Leu Ile Val Trp  Gln Val Met Tyr Gly  Asn Glu 
    1295                 1300                 1305         


<210>  154
<211>  1177
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ser Pro Gly Cys Met Leu Leu Phe Val Phe Gly Phe Val Gly Gly 
1               5                   10                  15      


Ala Val Val Ile Asn Ser Ala Ile Leu Val Ser Leu Ser Val Leu Leu 
            20                  25                  30          


Leu Val His Phe Ser Ile Ser Thr Gly Val Pro Ala Leu Thr Gln Asn 
        35                  40                  45              


Leu Pro Arg Ile Leu Arg Lys Glu Arg Pro Ile Ser Leu Gly Ile Phe 
    50                  55                  60                  


Pro Leu Pro Ala Gly Asp Gly Leu Leu Thr Pro Asp Ala Gln Lys Gly 
65                  70                  75                  80  


Gly Glu Thr Pro Gly Ser Glu Gln Trp Lys Phe Gln Glu Leu Ser Gln 
                85                  90                  95      


Pro Arg Ser His Thr Ser Leu Lys Asp Glu Leu Ser Asp Val Ser Gln 
            100                 105                 110         


Gly Gly Ser Lys Ala Thr Thr Pro Ala Ser Thr Ala Asn Ser Asp Val 
        115                 120                 125             


Ala Thr Ile Pro Thr Asp Thr Pro Leu Lys Glu Glu Asn Glu Gly Phe 
    130                 135                 140                 


Val Lys Val Thr Asp Ala Pro Asn Lys Ser Glu Ile Ser Lys His Ile 
145                 150                 155                 160 


Glu Val Gln Val Ala Gln Glu Thr Arg Asn Val Ser Thr Gly Ser Ala 
                165                 170                 175     


Glu Asn Glu Glu Lys Ser Glu Val Gln Ala Ile Ile Glu Ser Thr Pro 
            180                 185                 190         


Glu Leu Asp Met Asp Lys Asp Leu Ser Gly Tyr Lys Gly Ser Ser Thr 
        195                 200                 205             


Pro Thr Lys Gly Ile Glu Asn Lys Ala Phe Asp Arg Asn Thr Glu Ser 
    210                 215                 220                 


Leu Phe Glu Glu Leu Ser Ser Ala Gly Ser Gly Leu Ile Gly Asp Val 
225                 230                 235                 240 


Asp Glu Gly Ala Asp Leu Leu Gly Met Gly Arg Glu Val Glu Asn Leu 
                245                 250                 255     


Ile Leu Glu Asn Thr Gln Leu Leu Glu Thr Lys Asn Ala Leu Asn Ile 
            260                 265                 270         


Val Lys Asn Asp Leu Ile Ala Lys Val Asp Glu Leu Thr Cys Glu Lys 
        275                 280                 285             


Asp Val Leu Gln Gly Glu Leu Glu Ala Val Lys Gln Ala Lys Leu Lys 
    290                 295                 300                 


Leu Glu Glu Lys Asn Arg Glu Leu Glu Glu Glu Leu Arg Lys Ala Arg 
305                 310                 315                 320 


Ala Glu Ala Glu Asp Ala Arg Gln Lys Ala Lys Asp Asp Asp Asp Ser 
                325                 330                 335     


Asp Ile Pro Thr Ala Gln Arg Lys Arg Phe Thr Arg Val Glu Met Ala 
            340                 345                 350         


Arg Val Leu Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu Leu 
        355                 360                 365             


Gln Glu Ala Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu Asn 
    370                 375                 380                 


Pro Ala Met Gln Glu Lys Lys Arg Ser Ser Ile Trp Gln Phe Phe Ser 
385                 390                 395                 400 


Arg Leu Phe Ser Ser Ser Ser Asn Thr Thr Lys Lys Pro Glu Pro Pro 
                405                 410                 415     


Val Asn Leu Lys Tyr Asn Ala Pro Thr Ser His Val Thr Pro Ser Val 
            420                 425                 430         


Lys Lys Arg Ser Ser Thr Leu Ser Gln Leu Pro Gly Asp Lys Ser Lys 
        435                 440                 445             


Ala Phe Asp Phe Leu Ser Glu Glu Thr Glu Ala Ser Leu Ala Ser Arg 
    450                 455                 460                 


Arg Glu Gln Lys Arg Glu Gln Tyr Arg Gln Val Lys Ala His Val Gln 
465                 470                 475                 480 


Lys Glu Asp Gly Arg Val Gln Ala Phe Gly Trp Ser Leu Pro Gln Lys 
                485                 490                 495     


Tyr Lys Gln Val Thr Asn Gly Gln Gly Glu Asn Lys Met Lys Asn Leu 
            500                 505                 510         


Pro Val Pro Val Tyr Leu Arg Pro Leu Asp Glu Lys Asp Thr Ser Met 
        515                 520                 525             


Lys Leu Trp Cys Ala Val Gly Val Asn Leu Ser Gly Gly Lys Thr Arg 
    530                 535                 540                 


Asp Gly Gly Ser Val Val Gly Ala Ser Val Phe Tyr Lys Asp Val Ala 
545                 550                 555                 560 


Gly Leu Asp Thr Glu Gly Ser Lys Gln Arg Ser Ala Ser Gln Ser Ser 
                565                 570                 575     


Leu Asp Lys Leu Asp Gln Glu Leu Lys Glu Gln Gln Lys Glu Leu Lys 
            580                 585                 590         


Asn Gln Glu Glu Leu Ser Ser Leu Val Trp Ile Cys Thr Ser Thr His 
        595                 600                 605             


Ser Ala Thr Lys Val Leu Ile Ile Asp Ala Val Gln Pro Gly Asn Ile 
    610                 615                 620                 


Leu Asp Ser Phe Thr Val Cys Asn Ser His Val Leu Cys Ile Ala Ser 
625                 630                 635                 640 


Val Pro Gly Ala Arg Glu Thr Asp Tyr Pro Ala Gly Glu Asp Leu Ser 
                645                 650                 655     


Glu Ser Gly Gln Val Asp Lys Ala Ser Leu Cys Gly Ser Met Thr Ser 
            660                 665                 670         


Asn Ser Ser Ala Glu Thr Asp Ser Leu Leu Gly Gly Ile Thr Val Val 
        675                 680                 685             


Gly Cys Ser Ala Glu Gly Val Thr Gly Ala Ala Thr Ser Pro Ser Thr 
    690                 695                 700                 


Asn Gly Ala Ser Pro Val Met Asp Lys Pro Pro Glu Met Glu Ala Glu 
705                 710                 715                 720 


Asn Ser Glu Val Asp Glu Asn Val Pro Thr Ala Glu Glu Ala Thr Glu 
                725                 730                 735     


Ala Thr Glu Gly Asn Ala Gly Ser Ala Glu Asp Thr Val Asp Ile Ser 
            740                 745                 750         


Gln Thr Gly Val Tyr Thr Glu His Val Phe Thr Asp Pro Leu Gly Val 
        755                 760                 765             


Gln Ile Pro Glu Asp Leu Ser Pro Val Tyr Gln Ser Ser Asn Asp Ser 
    770                 775                 780                 


Asp Ala Tyr Lys Asp Gln Ile Ser Val Leu Pro Asn Glu Gln Asp Leu 
785                 790                 795                 800 


Val Arg Glu Glu Ala Gln Lys Met Ser Ser Leu Leu Pro Thr Met Trp 
                805                 810                 815     


Leu Gly Ala Gln Asn Gly Cys Leu Tyr Val His Ser Ser Val Ala Gln 
            820                 825                 830         


Trp Arg Lys Cys Leu His Ser Ile Lys Leu Lys Asp Ser Ile Leu Ser 
        835                 840                 845             


Ile Val His Val Lys Gly Ile Val Leu Val Ala Leu Ala Asp Gly Thr 
    850                 855                 860                 


Leu Ala Ile Phe His Arg Gly Val Asp Gly Gln Trp Asp Leu Ser Asn 
865                 870                 875                 880 


Tyr His Leu Leu Asp Leu Gly Arg Pro His His Ser Ile Arg Cys Met 
                885                 890                 895     


Thr Val Val His Asp Lys Val Trp Cys Gly Tyr Arg Asn Lys Ile Tyr 
            900                 905                 910         


Val Val Gln Pro Lys Ala Met Lys Ile Glu Lys Ser Phe Asp Ala His 
        915                 920                 925             


Pro Arg Lys Glu Ser Gln Val Arg Gln Leu Ala Trp Val Gly Asp Gly 
    930                 935                 940                 


Val Trp Val Ser Ile Arg Leu Asp Ser Thr Leu Arg Leu Tyr His Ala 
945                 950                 955                 960 


His Thr Tyr Gln His Leu Gln Asp Val Asp Ile Glu Pro Tyr Val Ser 
                965                 970                 975     


Lys Met Leu Gly Thr Gly Lys Leu Gly Phe Ser Phe Val Arg Ile Thr 
            980                 985                 990         


Ala Leu Met Val Ser Cys Asn Arg  Leu Trp Val Gly Thr  Gly Asn Gly 
        995                 1000                 1005             


Val Ile  Ile Ser Ile Pro Leu  Thr Glu Thr Val Ile  Leu His Gln 
    1010                 1015                 1020             


Gly Arg  Leu Leu Gly Leu Arg  Ala Asn Lys Thr Ser  Gly Val Pro 
    1025                 1030                 1035             


Gly Asn  Arg Pro Gly Ser Val  Ile Arg Val Tyr Gly  Asp Glu Asn 
    1040                 1045                 1050             


Ser Asp  Lys Val Thr Pro Gly  Thr Phe Ile Pro Tyr  Cys Ser Met 
    1055                 1060                 1065             


Ala His  Ala Gln Leu Cys Phe  His Gly His Arg Asp  Ala Val Lys 
    1070                 1075                 1080             


Phe Phe  Val Ala Val Pro Gly  Gln Val Ile Ser Pro  Gln Ser Ser 
    1085                 1090                 1095             


Ser Ser  Gly Thr Asp Leu Thr  Gly Asp Lys Ala Gly  Pro Ser Ala 
    1100                 1105                 1110             


Gln Glu  Pro Gly Ser Gln Thr  Pro Leu Lys Ser Met  Leu Val Ile 
    1115                 1120                 1125             


Ser Gly  Gly Glu Gly Tyr Ile  Asp Phe Arg Met Gly  Asp Glu Gly 
    1130                 1135                 1140             


Gly Glu  Ser Glu Leu Leu Gly  Glu Asp Leu Pro Leu  Glu Pro Ser 
    1145                 1150                 1155             


Val Thr  Lys Ala Glu Arg Ser  His Leu Ile Val Trp  Gln Val Met 
    1160                 1165                 1170             


Tyr Gly  Asn Glu 
    1175         


<210>  155
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ala Ala Ala Ala Ala Gly Thr Ala Thr Ser Gln Arg Phe Phe Gln 
1               5                   10                  15      


Ser Phe Ser Asp Ala Leu Ile Asp Glu Asp Pro Gln Ala Ala Leu Glu 
            20                  25                  30          


Glu Leu Thr Lys Ala Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr 
        35                  40                  45              


Cys Gln Arg Ala Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala 
    50                  55                  60                  


Val Ala Asp Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr 
65                  70                  75                  80  


Ala Met Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala 
                85                  90                  95      


Ala Ala Leu Glu Thr Phe Thr Glu Gly Gln Lys Leu Asp Ser Ala Asp 
            100                 105                 110         


Ala Asn Phe Ser Val Trp Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly 
        115                 120                 125             


Ser Glu Ser Glu Val Trp Thr His Gln Ser Lys Ile Lys Tyr Asp Trp 
    130                 135                 140                 


Tyr Gln Thr Glu Ser Gln Val Val Ile Thr Leu Met Ile Lys Asn Val 
145                 150                 155                 160 


Gln Lys Asn Asp Val Asn Val Glu Phe Ser Glu Lys Glu Leu Ser Ala 
                165                 170                 175     


Leu Val Lys Leu Pro Ser Gly Glu Asp Tyr Asn Leu Lys Leu Glu Leu 
            180                 185                 190         


Leu His Pro Ile Ile Pro Glu Gln Ser Thr Phe Lys Val Leu Ser Thr 
        195                 200                 205             


Lys Ile Glu Ile Lys Leu Lys Lys Pro Glu Ala Val Arg Trp Glu Lys 
    210                 215                 220                 


Leu Glu Gly Gln Gly Asp Val Pro Thr Pro Lys Gln Phe Val Ala Asp 
225                 230                 235                 240 


Val Lys Asn Leu Tyr Pro Ser Ser Ser Pro Tyr Thr Arg Asn Trp Asp 
                245                 250                 255     


Lys Leu Val Gly Glu Ile Lys Glu Glu Glu Lys Asn Glu Lys Leu Glu 
            260                 265                 270         


Gly Asp Ala Ala Leu Asn Arg Leu Phe Gln Gln Ile Tyr Ser Asp Gly 
        275                 280                 285             


Ser Asp Glu Val Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly 
    290                 295                 300                 


Gly Thr Val Leu Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val 
305                 310                 315                 320 


Glu Ile Asn Pro Pro Asp Asp Met Glu Trp Lys Lys Tyr 
                325                 330             


<210>  156
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ala Ala Ala Ala Ala Gly Thr Ala Thr Ser Gln Arg Phe Phe Gln 
1               5                   10                  15      


Ser Phe Ser Asp Ala Leu Ile Asp Glu Asp Pro Gln Ala Ala Leu Glu 
            20                  25                  30          


Glu Leu Thr Lys Ala Leu Glu Gln Lys Pro Asp Asp Ala Gln Tyr Tyr 
        35                  40                  45              


Cys Gln Arg Ala Tyr Cys His Ile Leu Leu Gly Asn Tyr Cys Val Ala 
    50                  55                  60                  


Val Ala Asp Ala Lys Lys Ser Leu Glu Leu Asn Pro Asn Asn Ser Thr 
65                  70                  75                  80  


Ala Met Leu Arg Lys Gly Ile Cys Glu Tyr His Glu Lys Asn Tyr Ala 
                85                  90                  95      


Ala Ala Leu Glu Thr Phe Thr Glu Gly Gln Lys Leu Asp Ile Glu Thr 
            100                 105                 110         


Gly Phe His Arg Val Gly Gln Ala Gly Leu Gln Leu Leu Thr Ser Ser 
        115                 120                 125             


Asp Pro Pro Ala Leu Asp Ser Gln Ser Ala Gly Ile Thr Gly Ala Asp 
    130                 135                 140                 


Ala Asn Phe Ser Val Trp Ile Lys Arg Cys Gln Glu Ala Gln Asn Gly 
145                 150                 155                 160 


Ser Glu Ser Glu Val Trp Thr His Gln Ser Lys Ile Lys Tyr Asp Trp 
                165                 170                 175     


Tyr Gln Thr Glu Ser Gln Val Val Ile Thr Leu Met Ile Lys Asn Val 
            180                 185                 190         


Gln Lys Asn Asp Val Asn Val Glu Phe Ser Glu Lys Glu Leu Ser Ala 
        195                 200                 205             


Leu Val Lys Leu Pro Ser Gly Glu Asp Tyr Asn Leu Lys Leu Glu Leu 
    210                 215                 220                 


Leu His Pro Ile Ile Pro Glu Gln Ser Thr Phe Lys Val Leu Ser Thr 
225                 230                 235                 240 


Lys Ile Glu Ile Lys Leu Lys Lys Pro Glu Ala Val Arg Trp Glu Lys 
                245                 250                 255     


Leu Glu Gly Gln Gly Asp Val Pro Thr Pro Lys Gln Phe Val Ala Asp 
            260                 265                 270         


Val Lys Asn Leu Tyr Pro Ser Ser Ser Pro Tyr Thr Arg Asn Trp Asp 
        275                 280                 285             


Lys Leu Val Gly Glu Ile Lys Glu Glu Glu Lys Asn Glu Lys Leu Glu 
    290                 295                 300                 


Gly Asp Ala Ala Leu Asn Arg Leu Phe Gln Gln Ile Tyr Ser Asp Gly 
305                 310                 315                 320 


Ser Asp Glu Val Lys Arg Ala Met Asn Lys Ser Phe Met Glu Ser Gly 
                325                 330                 335     


Gly Thr Val Leu Ser Thr Asn Trp Ser Asp Val Gly Lys Arg Lys Val 
            340                 345                 350         


Glu Ile Asn Pro Pro Asp Asp Met Glu Trp Lys Lys Tyr 
        355                 360                 365 


<210>  157
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Leu Ser Gln Lys Glu Val Ala Val Ala Asp Ala Lys Lys Ser Leu 
1               5                   10                  15      


Glu Leu Asn Pro Asn Asn Ser Thr Ala Met Leu Arg Lys Gly Ile Cys 
            20                  25                  30          


Glu Tyr His Glu Lys Asn Tyr Ala Ala Ala Leu Glu Thr Phe Thr Glu 
        35                  40                  45              


Gly Gln Lys Leu Asp Ser Ala Asp Ala Asn Phe Ser Val Trp Ile Lys 
    50                  55                  60                  


Arg Cys Gln Glu Ala Gln Asn Gly Ser Glu Ser Glu Val Trp Thr His 
65                  70                  75                  80  


Gln Ser Lys Ile Lys Tyr Asp Trp Tyr Gln Thr Glu Ser Gln Val Val 
                85                  90                  95      


Ile Thr Leu Met Ile Lys Asn Val Gln Lys Asn Asp Val Asn Val Glu 
            100                 105                 110         


Phe Ser Glu Lys Glu Leu Ser Ala Leu Val Lys Leu Pro Ser Gly Glu 
        115                 120                 125             


Asp Tyr Asn Leu Lys Leu Glu Leu Leu His Pro Ile Ile Pro Glu Gln 
    130                 135                 140                 


Ser Thr Phe Lys Val Leu Ser Thr Lys Ile Glu Ile Lys Leu Lys Lys 
145                 150                 155                 160 


Pro Glu Ala Val Arg Trp Glu Lys Leu Glu Gly Gln Gly Asp Val Pro 
                165                 170                 175     


Thr Pro Lys Gln Phe Val Ala Asp Val Lys Asn Leu Tyr Pro Ser Ser 
            180                 185                 190         


Ser Pro Tyr Thr Arg Asn Trp Asp Lys Leu Val Gly Glu Ile Lys Glu 
        195                 200                 205             


Glu Glu Lys Asn Glu Lys Leu Glu Gly Asp Ala Ala Leu Asn Arg Leu 
    210                 215                 220                 


Phe Gln Gln Ile Tyr Ser Asp Gly Ser Asp Glu Val Lys Arg Ala Met 
225                 230                 235                 240 


Asn Lys Ser Phe Met Glu Ser Gly Gly Thr Val Leu Ser Thr Asn Trp 
                245                 250                 255     


Ser Asp Val Gly Lys Arg Lys Val Glu Ile Asn Pro Pro Asp Asp Met 
            260                 265                 270         


Glu Trp Lys Lys Tyr 
        275         


<210>  158
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Gly Val Glu Lys 
                85                  90                  95      


Ala Lys Ala Met Pro Ser Pro Arg Ile Leu Lys Thr His Leu Ser Thr 
            100                 105                 110         


Gln Leu Leu Pro Pro Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr 
        115                 120                 125             


Val Ala Arg Asn Ala Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln 
    130                 135                 140                 


Arg Met Asn His Met Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe 
145                 150                 155                 160 


Glu Thr Phe Ile Asn Gly Lys Val Val Trp Gly Ser Trp Phe Asp His 
                165                 170                 175     


Val Lys Gly Trp Trp Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu 
            180                 185                 190         


Phe Tyr Glu Asp Ile Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val 
        195                 200                 205             


Met Gln Phe Met Gly Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile 
    210                 215                 220                 


Val Gln Glu Thr Ser Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn 
225                 230                 235                 240 


Arg Ser Thr Val Ser Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe 
                245                 250                 255     


Met Arg Lys Gly Thr Val Gly Asp Trp Lys Asn His Phe Thr Val Ala 
            260                 265                 270         


Gln Asn Glu Arg Phe Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr 
        275                 280                 285             


Ser Ile Asn Phe Cys Met Glu Leu 
    290                 295     


<210>  159
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Ala Leu Thr Ser Asp Leu Gly Lys Gln Ile Lys Leu Lys Glu Val 
1               5                   10                  15      


Glu Gly Thr Leu Leu Gln Pro Ala Thr Val Asp Asn Trp Ser Gln Ile 
            20                  25                  30          


Gln Ser Phe Glu Ala Lys Pro Asp Asp Leu Leu Ile Cys Thr Tyr Pro 
        35                  40                  45              


Lys Ala Gly Thr Thr Trp Ile Gln Glu Ile Val Asp Met Ile Glu Gln 
    50                  55                  60                  


Asn Gly Asp Val Glu Lys Cys Gln Arg Ala Ile Ile Gln His Arg His 
65                  70                  75                  80  


Pro Phe Ile Glu Trp Ala Arg Pro Pro Gln Pro Ser Glu Thr Gly Phe 
                85                  90                  95      


His His Val Ala Gln Ala Gly Leu Lys Leu Leu Ser Ser Ser Asn Pro 
            100                 105                 110         


Pro Ala Ser Thr Ser Gln Ser Ala Lys Ile Thr Asp Leu Leu Pro Pro 
        115                 120                 125             


Ser Phe Trp Glu Asn Asn Cys Lys Phe Leu Tyr Val Ala Arg Asn Ala 
    130                 135                 140                 


Lys Asp Cys Met Val Ser Tyr Tyr His Phe Gln Arg Met Asn His Met 
145                 150                 155                 160 


Leu Pro Asp Pro Gly Thr Trp Glu Glu Tyr Phe Glu Thr Phe Ile Asn 
                165                 170                 175     


Gly Lys Val Val Trp Gly Ser Trp Phe Asp His Val Lys Gly Trp Trp 
            180                 185                 190         


Glu Met Lys Asp Arg His Gln Ile Leu Phe Leu Phe Tyr Glu Asp Ile 
        195                 200                 205             


Lys Arg Asp Pro Lys His Glu Ile Arg Lys Val Met Gln Phe Met Gly 
    210                 215                 220                 


Lys Lys Val Asp Glu Thr Val Leu Asp Lys Ile Val Gln Glu Thr Ser 
225                 230                 235                 240 


Phe Glu Lys Met Lys Glu Asn Pro Met Thr Asn Arg Ser Thr Val Ser 
                245                 250                 255     


Lys Ser Ile Leu Asp Gln Ser Ile Ser Ser Phe Met Arg Lys Gly Thr 
            260                 265                 270         


Val Gly Asp Trp Lys Asn His Phe Thr Val Ala Gln Asn Glu Arg Phe 
        275                 280                 285             


Asp Glu Ile Tyr Arg Arg Lys Met Glu Gly Thr Ser Ile Asn Phe Cys 
    290                 295                 300                 


Met Glu Leu 
305         


<210>  160
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ser Trp Arg Pro Gln Pro Cys Cys Ile Ser Ser Cys Cys Leu Thr 
1               5                   10                  15      


Thr Asp Trp Val His Leu Trp Tyr Ile Trp Leu Leu Val Val Ile Gly 
            20                  25                  30          


Ala Leu Leu Leu Leu Cys Gly Leu Thr Ser Leu Cys Phe Arg Cys Cys 
        35                  40                  45              


Cys Leu Ser Arg Gln Gln Asn Gly Glu Asp Gly Gly Pro Pro Pro Cys 
    50                  55                  60                  


Glu Val Thr Val Ile Ala Phe Asp His Asp Ser Thr Leu Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Leu Gln Ser Val Phe Gly Pro Ala Ala Arg Arg Ile Leu 
                85                  90                  95      


Ala Val Ala His Ser His Ser Ser Leu Gly Gln Leu Pro Ser Ser Leu 
            100                 105                 110         


Asp Thr Leu Pro Gly Tyr Glu Glu Ala Leu His Met Ser Arg Phe Thr 
        115                 120                 125             


Val Ala Met Cys Gly Gln Lys Ala Pro Asp Leu Pro Pro Val Pro Glu 
    130                 135                 140                 


Glu Lys Gln Leu Pro Pro Thr Glu Lys Glu Ser Thr Arg Ile Val Asp 
145                 150                 155                 160 


Ser Trp Asn 
            


<210>  161
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Gly Val Arg Val His Val Val Ala Ala Ser Ala Leu Leu Tyr Phe 
1               5                   10                  15      


Ile Leu Leu Ser Gly Thr Arg Cys Glu Glu Asn Cys Gly Asn Pro Glu 
            20                  25                  30          


His Cys Leu Thr Thr Asp Trp Val His Leu Trp Tyr Ile Trp Leu Leu 
        35                  40                  45              


Val Val Ile Gly Ala Leu Leu Leu Leu Cys Gly Leu Thr Ser Leu Cys 
    50                  55                  60                  


Phe Arg Cys Cys Cys Leu Ser Arg Gln Gln Asn Gly Glu Asp Gly Gly 
65                  70                  75                  80  


Pro Pro Pro Cys Glu Val Thr Val Ile Ala Phe Asp His Asp Ser Thr 
                85                  90                  95      


Leu Gln Ser Thr Ile Thr Ser Leu Gln Ser Val Phe Gly Pro Ala Ala 
            100                 105                 110         


Arg Arg Ile Leu Ala Val Ala His Ser His Ser Ser Leu Gly Gln Leu 
        115                 120                 125             


Pro Ser Ser Leu Asp Thr Leu Pro Gly Tyr Glu Glu Ala Leu His Met 
    130                 135                 140                 


Ser Arg Phe Thr Val Ala Met Cys Gly Gln Lys Ala Pro Asp Leu Pro 
145                 150                 155                 160 


Pro Val Pro Glu Glu Lys Gln Leu Pro Pro Thr Glu Lys Glu Ser Thr 
                165                 170                 175     


Arg Ile Val Asp Ser Trp Asn 
            180             


<210>  162
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ala Asp His Val Gln Ser Leu Ala Gln Leu Glu Asn Leu Cys Lys 
1               5                   10                  15      


Gln Leu Tyr Glu Thr Thr Asp Thr Thr Thr Arg Leu Gln Ala Glu Lys 
            20                  25                  30          


Ala Leu Val Glu Phe Thr Asn Ser Pro Asp Cys Leu Ser Lys Cys Gln 
        35                  40                  45              


Leu Leu Leu Glu Arg Gly Ser Ser Ser Tyr Ser Gln Leu Leu Ala Ala 
    50                  55                  60                  


Thr Cys Leu Thr Lys Leu Val Ser Arg Thr Asn Asn Pro Leu Pro Leu 
65                  70                  75                  80  


Glu Gln Arg Ile Asp Ile Arg Asn Tyr Val Leu Asn Tyr Leu Ala Thr 
                85                  90                  95      


Arg Pro Lys Leu Ala Thr Phe Val Thr Gln Ala Leu Ile Gln Leu Tyr 
            100                 105                 110         


Ala Arg Ile Thr Lys Leu Gly Trp Phe Asp Cys Gln Lys Asp Asp Tyr 
        115                 120                 125             


Val Phe Arg Asn Ala Ile Thr Asp Val Thr Arg Phe Leu Gln Asp Ser 
    130                 135                 140                 


Val Glu Tyr Cys Ile Ile Gly Val Thr Ile Leu Ser Gln Leu Thr Asn 
145                 150                 155                 160 


Glu Ile Asn Gln Ala Asp Thr Thr His Pro Leu Thr Lys His Arg Lys 
                165                 170                 175     


Ile Ala Ser Ser Phe Arg Asp Ser Ser Leu Phe Asp Ile Phe Thr Leu 
            180                 185                 190         


Ser Cys Asn Leu Leu Lys Gln Ala Ser Gly Lys Asn Leu Asn Leu Asn 
        195                 200                 205             


Asp Glu Ser Gln His Gly Leu Leu Met Gln Leu Leu Lys Leu Thr His 
    210                 215                 220                 


Asn Cys Leu Asn Phe Asp Phe Ile Gly Thr Ser Thr Asp Glu Ser Ser 
225                 230                 235                 240 


Asp Asp Leu Cys Thr Val Gln Ile Pro Thr Ser Trp Arg Ser Ala Phe 
                245                 250                 255     


Leu Asp Ser Ser Thr Leu Gln Leu Phe Phe Asp Leu Tyr His Ser Ile 
            260                 265                 270         


Pro Pro Ser Phe Ser Pro Leu Val Leu Ser Cys Leu Val Gln Ile Ala 
        275                 280                 285             


Ser Val Arg Arg Ser Leu Phe Asn Asn Ala Glu Arg Ala Lys Phe Leu 
    290                 295                 300                 


Ser His Leu Val Asp Gly Val Lys Arg Ile Leu Glu Asn Pro Gln Ser 
305                 310                 315                 320 


Leu Ser Asp Pro Asn Asn Tyr His Glu Phe Cys Arg Leu Leu Ala Arg 
                325                 330                 335     


Leu Lys Ser Asn Tyr Gln Leu Gly Glu Leu Val Lys Val Glu Asn Tyr 
            340                 345                 350         


Pro Glu Val Ile Arg Leu Ile Ala Asn Phe Thr Val Thr Ser Leu Gln 
        355                 360                 365             


His Trp Glu Phe Ala Pro Asn Ser Val His Tyr Leu Leu Ser Leu Trp 
    370                 375                 380                 


Gln Arg Leu Ala Ala Ser Val Pro Tyr Val Lys Ala Thr Glu Pro His 
385                 390                 395                 400 


Met Leu Glu Thr Tyr Thr Pro Glu Val Thr Lys Ala Tyr Ile Thr Ser 
                405                 410                 415     


Arg Leu Glu Ser Val His Ile Ile Leu Arg Asp Gly Leu Glu Asp Pro 
            420                 425                 430         


Leu Glu Asp Thr Gly Leu Val Gln Gln Gln Leu Asp Gln Leu Ser Thr 
        435                 440                 445             


Ile Gly Arg Cys Glu Tyr Glu Lys Thr Cys Ala Leu Leu Val Gln Leu 
    450                 455                 460                 


Phe Asp Gln Ser Ala Gln Ser Tyr Gln Glu Leu Leu Gln Ser Ala Ser 
465                 470                 475                 480 


Ala Ser Pro Met Asp Ile Ala Val Gln Glu Gly Arg Leu Thr Trp Leu 
                485                 490                 495     


Val Tyr Ile Ile Gly Ala Val Ile Gly Gly Arg Val Ser Phe Ala Ser 
            500                 505                 510         


Thr Asp Glu Gln Asp Ala Met Asp Gly Glu Leu Val Cys Arg Val Leu 
        515                 520                 525             


Gln Leu Met Asn Leu Thr Asp Ser Arg Leu Ala Gln Ala Gly Asn Glu 
    530                 535                 540                 


Lys Leu Glu Leu Ala Met Leu Ser Phe Phe Glu Gln Phe Arg Lys Ile 
545                 550                 555                 560 


Tyr Ile Gly Asp Gln Val Gln Lys Ser Ser Lys Leu Tyr Arg Arg Leu 
                565                 570                 575     


Ser Glu Val Leu Gly Leu Asn Asp Glu Thr Met Val Leu Ser Val Phe 
            580                 585                 590         


Ile Gly Lys Ile Ile Thr Asn Leu Lys Tyr Trp Gly Arg Cys Glu Pro 
        595                 600                 605             


Ile Thr Ser Lys Thr Leu Gln Leu Leu Asn Asp Leu Ser Ile Gly Tyr 
    610                 615                 620                 


Ser Ser Val Arg Lys Leu Val Lys Leu Ser Ala Val Gln Phe Met Leu 
625                 630                 635                 640 


Asn Asn His Thr Ser Glu His Phe Ser Phe Leu Gly Ile Asn Asn Gln 
                645                 650                 655     


Ser Asn Leu Thr Asp Met Arg Cys Arg Thr Thr Phe Tyr Thr Ala Leu 
            660                 665                 670         


Gly Arg Leu Leu Met Val Asp Leu Gly Glu Asp Glu Asp Gln Tyr Glu 
        675                 680                 685             


Gln Phe Met Leu Pro Leu Thr Ala Ala Phe Glu Ala Val Ala Gln Met 
    690                 695                 700                 


Phe Ser Thr Asn Ser Phe Asn Glu Gln Glu Ala Lys Arg Thr Leu Val 
705                 710                 715                 720 


Gly Leu Val Arg Asp Leu Arg Gly Ile Ala Phe Ala Phe Asn Ala Lys 
                725                 730                 735     


Thr Ser Phe Met Met Leu Phe Glu Trp Ile Tyr Pro Ser Tyr Met Pro 
            740                 745                 750         


Ile Leu Gln Arg Ala Ile Glu Leu Trp Tyr His Asp Pro Ala Cys Thr 
        755                 760                 765             


Thr Pro Val Leu Lys Leu Met Ala Glu Leu Val His Asn Arg Ser Gln 
    770                 775                 780                 


Arg Leu Gln Phe Asp Val Ser Ser Pro Asn Gly Ile Leu Leu Phe Arg 
785                 790                 795                 800 


Glu Thr Ser Lys Met Ile Thr Met Tyr Gly Asn Arg Ile Leu Thr Leu 
                805                 810                 815     


Gly Glu Val Pro Lys Asp Gln Val Tyr Ala Leu Lys Leu Lys Gly Ile 
            820                 825                 830         


Ser Ile Cys Phe Ser Met Leu Lys Ala Ala Leu Ser Gly Ser Tyr Val 
        835                 840                 845             


Asn Phe Gly Val Phe Arg Leu Tyr Gly Asp Asp Ala Leu Asp Asn Ala 
    850                 855                 860                 


Leu Gln Thr Phe Ile Lys Leu Leu Leu Ser Ile Pro His Ser Asp Leu 
865                 870                 875                 880 


Leu Asp Tyr Pro Lys Leu Ser Gln Ser Tyr Tyr Ser Leu Leu Glu Val 
                885                 890                 895     


Leu Thr Gln Asp His Met Asn Phe Ile Ala Ser Leu Glu Pro His Val 
            900                 905                 910         


Ile Met Tyr Ile Leu Ser Ser Ile Ser Glu Gly Leu Thr Ala Leu Asp 
        915                 920                 925             


Thr Met Val Cys Thr Gly Cys Cys Ser Cys Leu Asp His Ile Val Thr 
    930                 935                 940                 


Tyr Leu Phe Lys Gln Leu Ser Arg Ser Thr Lys Lys Arg Thr Thr Pro 
945                 950                 955                 960 


Leu Asn Gln Glu Ser Asp Arg Phe Leu His Ile Met Gln Gln His Pro 
                965                 970                 975     


Glu Met Ile Gln Gln Met Leu Ser Thr Val Leu Asn Ile Ile Ile Phe 
            980                 985                 990         


Glu Asp Cys Arg Asn Gln Trp Ser  Met Ser Arg Pro Leu  Leu Gly Leu 
        995                 1000                 1005             


Ile Leu  Leu Asn Glu Lys Tyr  Phe Ser Asp Leu Arg  Asn Ser Ile 
    1010                 1015                 1020             


Val Asn  Ser Gln Pro Pro Glu  Lys Gln Gln Ala Met  His Leu Cys 
    1025                 1030                 1035             


Phe Glu  Asn Leu Met Glu Gly  Ile Glu Arg Asn Leu  Leu Thr Lys 
    1040                 1045                 1050             


Asn Arg  Asp Arg Phe Thr Gln  Asn Leu Ser Ala Phe  Arg Arg Glu 
    1055                 1060                 1065             


Val Asn  Asp Ser Met Lys Asn  Ser Thr Tyr Gly Val  Asn Ser Asn 
    1070                 1075                 1080             


Asp Met  Met Ser 
    1085         


<210>  163
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540             


<210>  164
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Thr Trp Arg Met Gly Pro Arg Phe Thr Met Leu Leu Ala Met Trp 
1               5                   10                  15      


Leu Val Cys Gly Ser Glu Pro His Pro His Ala Thr Ile Arg Gly Ser 
            20                  25                  30          


His Gly Gly Arg Lys Val Pro Leu Val Ser Pro Asp Ser Ser Arg Pro 
        35                  40                  45              


Ala Arg Phe Leu Arg His Thr Gly Arg Ser Arg Gly Ile Glu Arg Ser 
    50                  55                  60                  


Thr Leu Glu Glu Pro Asn Leu Gln Pro Leu Gln Arg Arg Arg Ser Val 
65                  70                  75                  80  


Pro Val Leu Arg Leu Ala Arg Pro Thr Glu Pro Pro Ala Arg Ser Asp 
                85                  90                  95      


Ile Asn Gly Ala Ala Val Arg Pro Glu Gln Arg Pro Ala Ala Arg Gly 
            100                 105                 110         


Ser Pro Arg Glu Met Ile Arg Asp Glu Gly Ser Ser Ala Arg Ser Arg 
        115                 120                 125             


Met Leu Arg Phe Pro Ser Gly Ser Ser Ser Pro Asn Ile Leu Ala Ser 
    130                 135                 140                 


Phe Ala Gly Lys Asn Arg Val Trp Val Ile Ser Ala Pro His Ala Ser 
145                 150                 155                 160 


Glu Gly Tyr Tyr Arg Leu Met Met Ser Leu Leu Lys Asp Asp Val Tyr 
                165                 170                 175     


Cys Glu Leu Ala Glu Arg His Ile Gln Gln Ile Val Leu Phe His Gln 
            180                 185                 190         


Ala Gly Glu Glu Gly Gly Lys Val Arg Arg Ile Thr Ser Glu Gly Gln 
        195                 200                 205             


Ile Leu Glu Gln Pro Leu Asp Pro Ser Leu Ile Pro Lys Leu Met Ser 
    210                 215                 220                 


Phe Leu Lys Leu Glu Lys Gly Lys Phe Gly Met Val Leu Leu Lys Lys 
225                 230                 235                 240 


Thr Leu Gln Val Glu Glu Arg Tyr Pro Tyr Pro Val Arg Leu Glu Ala 
                245                 250                 255     


Met Tyr Glu Val Ile Asp Gln Gly Pro Ile Arg Arg Ile Glu Lys Ile 
            260                 265                 270         


Arg Gln Lys Gly Phe Val Gln Lys Cys Lys Ala Ser Gly Val Glu Gly 
        275                 280                 285             


Gln Val Val Ala Glu Gly Asn Asp Gly Gly Gly Gly Ala Gly Arg Pro 
    290                 295                 300                 


Ser Leu Gly Ser Glu Lys Lys Lys Glu Asp Pro Arg Arg Ala Gln Val 
305                 310                 315                 320 


Pro Pro Thr Arg Glu Ser Arg Val Lys Val Leu Arg Lys Leu Ala Ala 
                325                 330                 335     


Thr Ala Pro Ala Leu Pro Gln Pro Pro Ser Thr Pro Arg Ala Thr Thr 
            340                 345                 350         


Leu Pro Pro Ala Pro Ala Thr Thr Val Thr Arg Ser Thr Ser Arg Ala 
        355                 360                 365             


Val Thr Val Ala Ala Arg Pro Met Thr Thr Thr Ala Phe Pro Thr Thr 
    370                 375                 380                 


Gln Arg Pro Trp Thr Pro Ser Pro Ser His Arg Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Glu Val Ile Thr Ala Arg Arg Pro Ser Val Ser Glu Asn Leu Tyr Pro 
                405                 410                 415     


Pro Ser Arg Lys Asp Gln His Arg Glu Arg Pro Gln Thr Thr Arg Arg 
            420                 425                 430         


Pro Ser Lys Ala Thr Ser Leu Glu Ser Phe Thr Asn Ala Pro Pro Thr 
        435                 440                 445             


Thr Ile Ser Glu Pro Ser Thr Arg Ala Ala Gly Pro Gly Arg Phe Arg 
    450                 455                 460                 


Asp Asn Arg Met Asp Arg Arg Glu His Gly His Arg Asp Pro Asn Val 
465                 470                 475                 480 


Val Pro Gly Pro Pro Lys Pro Ala Lys Glu Lys Pro Pro Lys Lys Lys 
                485                 490                 495     


Ala Gln Asp Lys Ile Leu Ser Asn Glu Tyr Glu Glu Lys Tyr Asp Leu 
            500                 505                 510         


Ser Arg Pro Thr Ala Ser Gln Leu Glu Asp Glu Leu Gln Val Gly Asn 
        515                 520                 525             


Val Pro Leu Lys Lys Ala Lys Glu Ser Lys Lys His Glu Lys Leu Glu 
    530                 535                 540                 


Lys Pro Glu Lys Glu Lys Lys Lys Lys Met Lys Asn Glu Asn Ala Asp 
545                 550                 555                 560 


Lys Leu Leu Lys Ser Glu Lys Gln Met Lys Lys Ser Glu Lys Lys Ser 
                565                 570                 575     


Lys Gln Glu Lys Glu Lys Ser Lys Lys Lys Lys Gly Gly Lys Thr Glu 
            580                 585                 590         


Gln Asp Gly Tyr Gln Lys Pro Thr Asn Lys His Phe Thr Gln Ser Pro 
        595                 600                 605             


Lys Lys Ser Val Ala Asp Leu Leu Gly Ser Phe Glu Gly Lys Arg Arg 
    610                 615                 620                 


Leu Leu Leu Ile Thr Ala Pro Lys Ala Glu Asn Asn Met Tyr Val Gln 
625                 630                 635                 640 


Gln Arg Asp Glu Tyr Leu Glu Ser Phe Cys Lys Met Ala Thr Arg Lys 
                645                 650                 655     


Ile Ser Val Ile Thr Ile Phe Gly Pro Val Asn Asn Ser Thr Met Lys 
            660                 665                 670         


Ile Asp His Phe Gln Leu Asp Asn Glu Lys Pro Met Arg Val Val Asp 
        675                 680                 685             


Asp Glu Asp Leu Val Asp Gln Arg Leu Ile Ser Glu Leu Arg Lys Glu 
    690                 695                 700                 


Tyr Gly Met Thr Tyr Asn Asp Phe Phe Met Val Leu Thr Asp Val Asp 
705                 710                 715                 720 


Leu Arg Val Lys Gln Tyr Tyr Glu Val Pro Ile Thr Met Lys Ser Val 
                725                 730                 735     


Phe Asp Leu Ile Asp Thr Phe Gln Ser Arg Ile Lys Asp Met Glu Lys 
            740                 745                 750         


Gln Lys Lys Glu Gly Ile Val Cys Lys Glu Asp Lys Lys Gln Ser Leu 
        755                 760                 765             


Glu Asn Phe Leu Ser Arg Phe Arg Trp Arg Arg Arg Leu Leu Val Ile 
    770                 775                 780                 


Ser Ala Pro Asn Asp Glu Asp Trp Ala Tyr Ser Gln Gln Leu Ser Ala 
785                 790                 795                 800 


Leu Ser Gly Gln Ala Cys Asn Phe Gly Leu Arg His Ile Thr Ile Leu 
                805                 810                 815     


Lys Leu Leu Gly Val Gly Glu Glu Val Gly Gly Val Leu Glu Leu Phe 
            820                 825                 830         


Pro Ile Asn Gly Ser Ser Val Val Glu Arg Glu Asp Val Pro Ala His 
        835                 840                 845             


Leu Val Lys Asp Ile Arg Asn Tyr Phe Gln Val Ser Pro Glu Tyr Phe 
    850                 855                 860                 


Ser Met Leu Leu Val Gly Lys Asp Gly Asn Val Lys Ser Trp Tyr Pro 
865                 870                 875                 880 


Ser Pro Met Trp Ser Met Val Ile Val Tyr Asp Leu Ile Asp Ser Met 
                885                 890                 895     


Gln Leu Arg Arg Gln Glu Met Ala Ile Gln Gln Ser Leu Gly Met Arg 
            900                 905                 910         


Cys Pro Glu Asp Glu Tyr Ala Gly Tyr Gly Tyr His Ser Tyr His Gln 
        915                 920                 925             


Gly Tyr Gln Asp Gly Tyr Gln Asp Asp Tyr Arg His His Glu Ser Tyr 
    930                 935                 940                 


His His Gly Tyr Pro Tyr 
945                 950 


<210>  165
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Arg Lys Pro Ala Ala Gly Phe Leu Pro Ser Leu Leu Lys Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Ala Pro Ala Ala Ala Gln Asp Ser Thr Gln Ala Ser 
            20                  25                  30          


Thr Pro Gly Ser Pro Leu Ser Pro Thr Glu Tyr Glu Arg Phe Phe Ala 
        35                  40                  45              


Leu Leu Thr Pro Thr Trp Lys Ala Glu Thr Thr Cys Arg Leu Arg Ala 
    50                  55                  60                  


Thr His Gly Cys Arg Asn Pro Thr Leu Val Gln Leu Asp Gln Tyr Glu 
65                  70                  75                  80  


Asn His Gly Leu Val Pro Asp Gly Ala Val Cys Ser Asn Leu Pro Tyr 
                85                  90                  95      


Ala Ser Trp Phe Glu Ser Phe Cys Gln Phe Thr His Tyr Arg Cys Ser 
            100                 105                 110         


Asn His Val Tyr Tyr Ala Lys Arg Val Leu Cys Ser Gln Pro Val Ser 
        115                 120                 125             


Ile Leu Ser Pro Asn Thr Leu Lys Glu Ile Glu Ala Ser Ala Glu Val 
    130                 135                 140                 


Ser Pro Thr Thr Met Thr Ser Pro Ile Ser Pro His Phe Thr Val Thr 
145                 150                 155                 160 


Glu Arg Gln Thr Phe Gln Pro Trp Pro Glu Arg Leu Ser Asn Asn Val 
                165                 170                 175     


Glu Glu Leu Leu Gln Ser Ser Leu Ser Leu Gly Gly Gln Glu Gln Ala 
            180                 185                 190         


Pro Glu His Lys Gln Glu Gln Gly Val Glu His Arg Gln Glu Pro Thr 
        195                 200                 205             


Gln Glu His Lys Gln Glu Glu Gly Gln Lys Gln Glu Glu Gln Glu Glu 
    210                 215                 220                 


Glu Gln Glu Glu Glu Gly Lys Gln Glu Glu Gly Gln Gly Thr Lys Glu 
225                 230                 235                 240 


Gly Arg Glu Ala Val Ser Gln Leu Gln Thr Asp Ser Glu Pro Lys Phe 
                245                 250                 255     


His Ser Glu Ser Leu Ser Ser Asn Pro Ser Ser Phe Ala Pro Arg Val 
            260                 265                 270         


Arg Glu Val Glu Ser Thr Pro Met Ile Met Glu Asn Ile Gln Glu Leu 
        275                 280                 285             


Ile Arg Ser Ala Gln Glu Ile Asp Glu Met Asn Glu Ile Tyr Asp Glu 
    290                 295                 300                 


Asn Ser Tyr Trp Arg Asn Gln Asn Pro Gly Ser Leu Leu Gln Leu Pro 
305                 310                 315                 320 


His Thr Glu Ala Leu Leu Val Leu Cys Tyr Ser Ile Val Glu Asn Thr 
                325                 330                 335     


Cys Ile Ile Thr Pro Thr Ala Lys Ala Trp Lys Tyr Met Glu Glu Glu 
            340                 345                 350         


Ile Leu Gly Phe Gly Lys Ser Val Cys Asp Ser Leu Gly Arg Arg His 
        355                 360                 365             


Met Ser Thr Cys Ala Leu Cys Asp Phe Cys Ser Leu Lys Leu Glu Gln 
    370                 375                 380                 


Cys His Ser Glu Ala Ser Leu Gln Arg Gln Gln Cys Asp Thr Ser His 
385                 390                 395                 400 


Lys Thr Pro Phe Val Ser Pro Leu Leu Ala Ser Gln Ser Leu Ser Ile 
                405                 410                 415     


Gly Asn Gln Val Gly Ser Pro Glu Ser Gly Arg Phe Tyr Gly Leu Asp 
            420                 425                 430         


Leu Tyr Gly Gly Leu His Met Asp Phe Trp Cys Ala Arg Leu Ala Thr 
        435                 440                 445             


Lys Gly Cys Glu Asp Val Arg Val Ser Gly Trp Leu Gln Thr Glu Phe 
    450                 455                 460                 


Leu Ser Phe Gln Asp Gly Asp Phe Pro Thr Lys Ile Cys Asp Thr Asp 
465                 470                 475                 480 


Tyr Ile Gln Tyr Pro Asn Tyr Cys Ser Phe Lys Ser Gln Gln Cys Leu 
                485                 490                 495     


Met Arg Asn Arg Asn Arg Lys Val Ser Arg Met Arg Cys Leu Gln Asn 
            500                 505                 510         


Glu Thr Tyr Ser Ala Leu Ser Pro Gly Lys Ser Glu Asp Val Val Leu 
        515                 520                 525             


Arg Trp Ser Gln Glu Phe Ser Thr Leu Thr Leu Gly Gln Phe Gly 
    530                 535                 540             


<210>  166
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


<210>  167
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Asn Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr 
1               5                   10                  15      


Ala Pro Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro 
            20                  25                  30          


Ser Cys Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala 
        35                  40                  45              


Ala Thr Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His 
    50                  55                  60                  


Ala Cys Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile 
65                  70                  75                  80  


Thr Val Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu 
                85                  90                  95      


Ile Gln Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys 
            100                 105                 110         


Arg Gly Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Arg Ile Met Ser 
        115                 120                 125             


Tyr Ile Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys 
    130                 135                 140                 


Cys Lys Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu 
145                 150                 155                 160 


Asn Asp Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu 
                165                 170                 175     


Gly Asp Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe 
            180                 185                 190         


Leu Ala Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala 
        195                 200                 205             


Val Ser Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu 
    210                 215                 220                 


Lys Cys Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu 
225                 230                 235                 240 


Glu Glu Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg 
                245                 250                 255     


Ser Cys Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala 
            260                 265                 270         


Phe Leu Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu 
        275                 280                 285             


Leu Met Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys 
    290                 295                 300                 


Gln Leu Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp 
305                 310                 315                 320 


Ile Ile Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn 
                325                 330                 335     


Pro Gly Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro 
            340                 345                 350         


Cys Phe Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe 
        355                 360                 365             


Ser Asp Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly 
    370                 375                 380                 


Val Ala Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys 
385                 390                 395                 400 


Gln Lys Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp 
                405                 410                 415     


Phe Ser Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val 
            420                 425                 430         


Cys Phe Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala 
        435                 440                 445             


Leu Gly Val 
    450     


<210>  168
<211>  2131
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Pro Leu Ser Pro Pro Ala Gln Gly Asp Pro Gly Glu Pro Ser Pro 
1               5                   10                  15      


Cys Arg Pro Pro Lys Lys His Thr Thr Phe His Leu Trp Arg Ser Lys 
            20                  25                  30          


Lys Lys Gln Gln Pro Ala Pro Pro Asp Cys Gly Val Phe Val Pro His 
        35                  40                  45              


Pro Leu Pro Ala Pro Ala Gly Glu Ala Arg Ala Leu Asp Val Val Asp 
    50                  55                  60                  


Gly Lys Tyr Val Val Arg Asp Ser Gln Glu Phe Pro Leu His Cys Gly 
65                  70                  75                  80  


Glu Ser Gln Phe Phe His Thr Thr Ser Glu Ala Leu Gly Ser Leu Leu 
                85                  90                  95      


Leu Glu Ser Gly Ile Phe Lys Lys Ser Arg Ala Gln Pro Pro Glu Asp 
            100                 105                 110         


Asn Arg Arg Lys Pro Val Leu Gly Lys Leu Gly Thr Leu Phe Thr Ala 
        115                 120                 125             


Gly Arg Arg Arg Asn Ser Arg Asn Gly Leu Glu Ser Pro Thr Arg Ser 
    130                 135                 140                 


Asn Ala Lys Pro Leu Ser Pro Lys Asp Val Val Ala Ser Pro Lys Leu 
145                 150                 155                 160 


Pro Glu Arg Glu Ser Glu Arg Ser Arg Ser Gln Ser Ser Gln Leu Lys 
                165                 170                 175     


Gln Thr Asp Thr Ser Glu Glu Gly Ser Pro Arg Glu Asn Pro Arg Glu 
            180                 185                 190         


Ala Glu Gly Glu Leu Pro Glu Ser Gly Gly Pro Ala Ala Pro Pro Asp 
        195                 200                 205             


Ala Glu Leu Ser Pro Arg Trp Ser Ser Ser Ala Ala Ala Val Ala Val 
    210                 215                 220                 


Gln Gln Cys His Glu Asn Asp Ser Pro Gln Leu Glu Pro Leu Glu Ala 
225                 230                 235                 240 


Glu Gly Glu Pro Phe Pro Asp Ala Thr Thr Thr Ala Lys Gln Leu His 
                245                 250                 255     


Ser Ser Pro Gly Asn Ser Ser Arg Gln Glu Asn Ala Glu Thr Pro Ala 
            260                 265                 270         


Arg Ser Pro Gly Glu Asp Ala Ser Pro Gly Ala Gly His Glu Gln Glu 
        275                 280                 285             


Ala Phe Leu Gly Val Arg Gly Ala Pro Gly Ser Pro Thr Gln Glu Arg 
    290                 295                 300                 


Pro Ala Gly Gly Leu Gly Glu Ala Pro Asn Gly Ala Pro Ser Val Cys 
305                 310                 315                 320 


Ala Glu Glu Gly Ser Leu Gly Pro Arg Asn Ala Arg Ser Gln Pro Pro 
                325                 330                 335     


Lys Gly Ala Ser Asp Leu Pro Gly Glu Pro Pro Ala Glu Gly Ala Ala 
            340                 345                 350         


His Thr Ala Ser Ser Ala Gln Ala Asp Cys Thr Ala Arg Pro Lys Gly 
        355                 360                 365             


His Ala His Pro Ala Lys Val Leu Thr Leu Asp Ile Tyr Leu Ser Lys 
    370                 375                 380                 


Thr Glu Gly Ala Gln Val Asp Glu Pro Val Val Ile Thr Pro Arg Ala 
385                 390                 395                 400 


Glu Asp Cys Gly Asp Trp Asp Asp Met Glu Lys Arg Ser Ser Gly Arg 
                405                 410                 415     


Arg Ser Gly Arg Arg Arg Gly Ser Gln Lys Ser Thr Asp Ser Pro Gly 
            420                 425                 430         


Ala Asp Ala Glu Leu Pro Glu Ser Ala Ala Arg Asp Asp Ala Val Phe 
        435                 440                 445             


Asp Asp Glu Val Ala Pro Asn Ala Ala Ser Asp Asn Ala Ser Ala Glu 
    450                 455                 460                 


Lys Lys Val Lys Ser Pro Arg Ala Ala Leu Asp Gly Gly Val Ala Ser 
465                 470                 475                 480 


Ala Ala Ser Pro Glu Ser Lys Pro Ser Pro Gly Thr Lys Gly Gln Leu 
                485                 490                 495     


Arg Gly Glu Ser Asp Arg Ser Lys Gln Pro Pro Pro Ala Ser Ser Pro 
            500                 505                 510         


Thr Lys Arg Lys Gly Arg Ser Arg Ala Leu Glu Ala Val Pro Ala Pro 
        515                 520                 525             


Pro Ala Ser Gly Pro Arg Ala Pro Ala Lys Glu Ser Pro Pro Lys Arg 
    530                 535                 540                 


Val Pro Asp Pro Ser Pro Val Thr Lys Gly Thr Ala Ala Glu Ser Gly 
545                 550                 555                 560 


Glu Glu Ala Ala Arg Ala Ile Pro Arg Glu Leu Pro Val Lys Ser Ser 
                565                 570                 575     


Ser Leu Leu Pro Glu Ile Lys Pro Glu His Lys Arg Gly Pro Leu Pro 
            580                 585                 590         


Asn His Phe Asn Gly Arg Ala Glu Gly Gly Arg Ser Arg Glu Leu Gly 
        595                 600                 605             


Arg Ala Ala Gly Ala Pro Gly Ala Ser Asp Ala Asp Gly Leu Lys Pro 
    610                 615                 620                 


Arg Asn His Phe Gly Val Gly Arg Ser Thr Val Thr Thr Lys Val Thr 
625                 630                 635                 640 


Leu Pro Ala Lys Pro Lys His Val Glu Leu Asn Leu Lys Thr Pro Lys 
                645                 650                 655     


Asn Leu Asp Ser Leu Gly Asn Glu His Asn Pro Phe Ser Gln Pro Val 
            660                 665                 670         


His Lys Gly Asn Thr Ala Thr Lys Ile Ser Leu Phe Glu Asn Lys Arg 
        675                 680                 685             


Thr Asn Ser Ser Pro Arg His Thr Asp Ile Arg Gly Gln Arg Asn Thr 
    690                 695                 700                 


Pro Ala Ser Ser Lys Thr Phe Val Gly Arg Ala Lys Leu Asn Leu Ala 
705                 710                 715                 720 


Lys Lys Ala Lys Glu Met Glu Gln Pro Glu Lys Lys Val Met Pro Asn 
                725                 730                 735     


Ser Pro Gln Asn Gly Val Leu Val Lys Glu Thr Ala Ile Glu Thr Lys 
            740                 745                 750         


Val Thr Val Ser Glu Glu Glu Ile Leu Pro Ala Thr Arg Gly Met Asn 
        755                 760                 765             


Gly Asp Ser Ser Glu Asn Gln Ala Leu Gly Pro Gln Pro Asn Gln Asp 
    770                 775                 780                 


Asp Lys Ala Asp Val Gln Thr Asp Ala Gly Cys Leu Ser Glu Pro Val 
785                 790                 795                 800 


Ala Ser Ala Leu Ile Pro Val Lys Asp His Lys Leu Leu Glu Lys Glu 
                805                 810                 815     


Asp Ser Glu Ala Ala Asp Ser Lys Ser Leu Val Leu Glu Asn Val Thr 
            820                 825                 830         


Asp Thr Ala Gln Asp Ile Pro Thr Thr Val Asp Thr Lys Asp Leu Pro 
        835                 840                 845             


Pro Thr Ala Met Pro Lys Pro Gln His Thr Phe Ser Asp Ser Gln Ser 
    850                 855                 860                 


Pro Ala Glu Ser Ser Pro Gly Pro Ser Leu Ser Leu Ser Ala Pro Ala 
865                 870                 875                 880 


Pro Gly Asp Val Pro Lys Asp Thr Cys Val Gln Ser Pro Ile Ser Ser 
                885                 890                 895     


Phe Pro Cys Thr Asp Leu Lys Val Ser Glu Asn His Lys Gly Cys Val 
            900                 905                 910         


Leu Pro Val Ser Arg Gln Asn Asn Glu Lys Met Pro Leu Leu Glu Leu 
        915                 920                 925             


Gly Gly Glu Thr Thr Pro Pro Leu Ser Thr Glu Arg Ser Pro Glu Ala 
    930                 935                 940                 


Val Gly Ser Glu Cys Pro Ser Arg Val Leu Val Gln Val Arg Ser Phe 
945                 950                 955                 960 


Val Leu Pro Val Glu Ser Thr Gln Asp Val Ser Ser Gln Val Ile Pro 
                965                 970                 975     


Glu Ser Ser Glu Val Arg Glu Val Gln Leu Pro Thr Cys His Ser Asn 
            980                 985                 990         


Glu Pro Glu Val Val Ser Val Ala  Ser Cys Ala Pro Pro  Gln Glu Glu 
        995                 1000                 1005             


Val Leu  Gly Asn Glu His Ser  His Cys Thr Ala Glu  Leu Ala Ala 
    1010                 1015                 1020             


Lys Ser  Gly Pro Gln Val Ile  Pro Pro Ala Ser Glu  Lys Thr Leu 
    1025                 1030                 1035             


Pro Ile  Gln Ala Gln Ser Gln  Gly Ser Arg Thr Pro  Leu Met Ala 
    1040                 1045                 1050             


Glu Ser  Ser Pro Thr Asn Ser  Pro Ser Ser Gly Asn  His Leu Ala 
    1055                 1060                 1065             


Thr Pro  Gln Arg Pro Asp Gln  Thr Val Thr Asn Gly  Gln Asp Ser 
    1070                 1075                 1080             


Pro Ala  Ser Leu Leu Asn Ile  Ser Ala Gly Ser Asp  Asp Ser Val 
    1085                 1090                 1095             


Phe Asp  Ser Ser Ser Asp Met  Glu Lys Phe Thr Glu  Ile Ile Lys 
    1100                 1105                 1110             


Gln Met  Asp Ser Ala Val Cys  Met Pro Met Lys Arg  Lys Lys Ala 
    1115                 1120                 1125             


Arg Met  Pro Asn Ser Pro Ala  Pro His Phe Ala Met  Pro Pro Ile 
    1130                 1135                 1140             


His Glu  Asp His Leu Glu Lys  Val Phe Asp Pro Lys  Val Phe Thr 
    1145                 1150                 1155             


Phe Gly  Leu Gly Lys Lys Lys  Glu Ser Gln Pro Glu  Met Ser Pro 
    1160                 1165                 1170             


Ala Leu  His Leu Met Gln Asn  Leu Asp Thr Lys Ser  Lys Leu Arg 
    1175                 1180                 1185             


Pro Lys  Arg Ala Ser Ala Glu  Gln Ser Val Leu Phe  Lys Ser Leu 
    1190                 1195                 1200             


His Thr  Asn Thr Asn Gly Asn  Ser Glu Pro Leu Val  Met Pro Glu 
    1205                 1210                 1215             


Ile Asn  Asp Lys Glu Asn Arg  Asp Val Thr Asn Gly  Gly Ile Lys 
    1220                 1225                 1230             


Arg Ser  Arg Leu Glu Lys Ser  Ala Leu Phe Ser Ser  Leu Leu Ser 
    1235                 1240                 1245             


Ser Leu  Pro Gln Asp Lys Ile  Phe Ser Pro Ser Val  Thr Ser Val 
    1250                 1255                 1260             


Asn Thr  Met Thr Thr Ala Phe  Ser Thr Ser Gln Asn  Gly Ser Leu 
    1265                 1270                 1275             


Ser Gln  Ser Ser Val Ser Gln  Pro Thr Thr Glu Gly  Ala Pro Pro 
    1280                 1285                 1290             


Cys Gly  Leu Asn Lys Glu Gln  Ser Asn Leu Leu Pro  Asp Asn Ser 
    1295                 1300                 1305             


Leu Lys  Val Phe Asn Phe Asn  Ser Ser Ser Thr Ser  His Ser Ser 
    1310                 1315                 1320             


Leu Lys  Ser Pro Ser His Met  Glu Lys Tyr Pro Gln  Lys Glu Lys 
    1325                 1330                 1335             


Thr Lys  Glu Asp Leu Asp Ser  Arg Ser Asn Leu His  Leu Pro Glu 
    1340                 1345                 1350             


Thr Lys  Phe Ser Glu Leu Ser  Lys Leu Lys Asn Asp  Asp Met Glu 
    1355                 1360                 1365             


Lys Ala  Asn His Ile Glu Ser  Val Ile Lys Ser Asn  Leu Pro Asn 
    1370                 1375                 1380             


Cys Ala  Asn Ser Asp Thr Asp  Phe Met Gly Leu Phe  Lys Ser Ser 
    1385                 1390                 1395             


Arg Tyr  Asp Pro Ser Ile Ser  Phe Ser Gly Met Ser  Leu Ser Asp 
    1400                 1405                 1410             


Thr Met  Thr Leu Arg Gly Ser  Val Gln Asn Lys Leu  Asn Pro Arg 
    1415                 1420                 1425             


Pro Gly  Lys Val Val Ile Tyr  Ser Glu Pro Asp Val  Ser Glu Lys 
    1430                 1435                 1440             


Cys Ile  Glu Val Phe Ser Asp  Ile Gln Asp Cys Ser  Ser Trp Ser 
    1445                 1450                 1455             


Leu Ser  Pro Val Ile Leu Ile  Lys Val Val Arg Gly  Cys Trp Ile 
    1460                 1465                 1470             


Leu Tyr  Glu Gln Pro Asn Phe  Glu Gly His Ser Ile  Pro Leu Glu 
    1475                 1480                 1485             


Glu Gly  Glu Leu Glu Leu Ser  Gly Leu Trp Gly Ile  Glu Asp Ile 
    1490                 1495                 1500             


Leu Glu  Arg His Glu Glu Ala  Glu Ser Asp Lys Pro  Val Val Ile 
    1505                 1510                 1515             


Gly Ser  Ile Arg His Val Val  Gln Asp Tyr Arg Val  Ser His Ile 
    1520                 1525                 1530             


Asp Leu  Phe Thr Glu Pro Glu  Gly Leu Gly Ile Leu  Ser Ser Tyr 
    1535                 1540                 1545             


Phe Asp  Asp Thr Glu Glu Met  Gln Gly Phe Gly Val  Met Gln Lys 
    1550                 1555                 1560             


Thr Cys  Ser Met Lys Val His  Trp Gly Thr Trp Leu  Ile Tyr Glu 
    1565                 1570                 1575             


Glu Pro  Gly Phe Gln Gly Val  Pro Phe Ile Leu Glu  Pro Gly Glu 
    1580                 1585                 1590             


Tyr Pro  Asp Leu Ser Phe Trp  Asp Thr Glu Glu Ala  Tyr Ile Gly 
    1595                 1600                 1605             


Ser Met  Arg Pro Leu Lys Met  Gly Gly Arg Lys Val  Glu Phe Pro 
    1610                 1615                 1620             


Thr Asp  Pro Lys Val Val Val  Tyr Glu Lys Pro Phe  Phe Glu Gly 
    1625                 1630                 1635             


Lys Cys  Val Glu Leu Glu Thr  Gly Met Cys Ser Phe  Val Met Glu 
    1640                 1645                 1650             


Gly Gly  Glu Thr Glu Glu Ala  Thr Gly Asp Asp His  Leu Pro Phe 
    1655                 1660                 1665             


Thr Ser  Val Gly Ser Met Lys  Val Leu Arg Gly Ile  Trp Val Ala 
    1670                 1675                 1680             


Tyr Glu  Lys Pro Gly Phe Thr  Gly His Gln Tyr Leu  Leu Glu Glu 
    1685                 1690                 1695             


Gly Glu  Tyr Arg Asp Trp Lys  Ala Trp Gly Gly Tyr  Asn Gly Glu 
    1700                 1705                 1710             


Leu Gln  Ser Leu Arg Pro Ile  Leu Gly Asp Phe Ser  Asn Ala His 
    1715                 1720                 1725             


Met Ile  Met Tyr Ser Glu Lys  Asn Phe Gly Ser Lys  Gly Ser Ser 
    1730                 1735                 1740             


Ile Asp  Val Leu Gly Ile Val  Ala Asn Leu Lys Glu  Thr Gly Tyr 
    1745                 1750                 1755             


Gly Val  Lys Thr Gln Ser Ile  Asn Val Leu Ser Gly  Val Trp Val 
    1760                 1765                 1770             


Ala Tyr  Glu Asn Pro Asp Phe  Thr Gly Glu Gln Tyr  Ile Leu Asp 
    1775                 1780                 1785             


Lys Gly  Phe Tyr Thr Ser Phe  Glu Asp Trp Gly Gly  Lys Asn Cys 
    1790                 1795                 1800             


Lys Ile  Ser Ser Val Gln Pro  Ile Cys Leu Asp Ser  Phe Thr Gly 
    1805                 1810                 1815             


Pro Arg  Arg Arg Asn Gln Ile  His Leu Phe Ser Glu  Pro Gln Phe 
    1820                 1825                 1830             


Gln Gly  His Ser Gln Ser Phe  Glu Glu Thr Thr Ser  Gln Ile Asp 
    1835                 1840                 1845             


Asp Ser  Phe Ser Thr Lys Ser  Cys Arg Val Ser Gly  Gly Ser Trp 
    1850                 1855                 1860             


Val Val  Tyr Asp Gly Glu Asn  Phe Thr Gly Asn Gln  Tyr Val Leu 
    1865                 1870                 1875             


Glu Glu  Gly His Tyr Pro Cys  Leu Ser Ala Met Gly  Cys Pro Pro 
    1880                 1885                 1890             


Gly Ala  Thr Phe Lys Ser Leu  Arg Phe Ile Asp Val  Glu Phe Ser 
    1895                 1900                 1905             


Glu Pro  Thr Ile Ile Leu Phe  Glu Arg Glu Asp Phe  Lys Gly Lys 
    1910                 1915                 1920             


Lys Ile  Glu Leu Asn Ala Glu  Thr Val Asn Leu Arg  Ser Leu Gly 
    1925                 1930                 1935             


Phe Asn  Thr Gln Ile Arg Ser  Val Gln Val Ile Gly  Gly Ile Trp 
    1940                 1945                 1950             


Val Thr  Tyr Glu Tyr Gly Ser  Tyr Arg Gly Arg Gln  Phe Leu Leu 
    1955                 1960                 1965             


Ser Pro  Ala Glu Val Pro Asn  Trp Tyr Glu Phe Ser  Gly Cys Arg 
    1970                 1975                 1980             


Gln Ile  Gly Ser Leu Arg Pro  Phe Val Gln Lys Arg  Ile Tyr Phe 
    1985                 1990                 1995             


Arg Leu  Arg Asn Lys Ala Thr  Gly Leu Phe Met Ser  Thr Asn Gly 
    2000                 2005                 2010             


Asn Leu  Glu Asp Leu Lys Leu  Leu Arg Ile Gln Val  Met Glu Asp 
    2015                 2020                 2025             


Val Gly  Ala Asp Asp Gln Ile  Trp Ile Tyr Gln Glu  Gly Cys Ile 
    2030                 2035                 2040             


Lys Cys  Arg Ile Ala Glu Asp  Cys Cys Leu Thr Ile  Val Gly Ser 
    2045                 2050                 2055             


Leu Val  Thr Ser Gly Ser Lys  Leu Gly Leu Ala Leu  Asp Gln Asn 
    2060                 2065                 2070             


Ala Asp  Ser Gln Phe Trp Ser  Leu Lys Ser Asp Gly  Arg Ile Tyr 
    2075                 2080                 2085             


Ser Lys  Leu Lys Pro Asn Leu  Val Leu Asp Ile Lys  Gly Gly Thr 
    2090                 2095                 2100             


Gln Tyr  Asp Gln Asn His Ile  Ile Leu Asn Thr Val  Ser Lys Glu 
    2105                 2110                 2115             


Lys Phe  Thr Gln Val Trp Glu  Ala Met Val Leu Tyr  Thr 
    2120                 2125                 2130     


<210>  169
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Met Ala Tyr Ser Asp Thr Thr Met Met Ser Asp Asp Ile Asp Trp 
1               5                   10                  15      


Leu Arg Ser His Arg Gly Val Cys Lys Val Asp Leu Tyr Asn Pro Glu 
            20                  25                  30          


Gly Gln Gln Asp Gln Asp Arg Lys Val Ile Cys Phe Val Asp Val Ser 
        35                  40                  45              


Thr Leu Asn Val Glu Asp Lys Asp Tyr Lys Asp Ala Ala Ser Ser Ser 
    50                  55                  60                  


Ser Glu Gly Asn Leu Asn Leu Gly Ser Leu Glu Glu Lys Glu Ile Ile 
65                  70                  75                  80  


Val Ile Lys Asp Thr Glu Lys Lys Asp Gln Ser Lys Thr Glu Gly Ser 
                85                  90                  95      


Val Cys Leu Phe Lys Gln Ala Pro Ser Asp Pro Val Ser Val Leu Asn 
            100                 105                 110         


Trp Leu Leu Ser Asp Leu Gln Lys Tyr Ala Leu Gly Phe Gln His Ala 
        115                 120                 125             


Leu Ser Pro Ser Thr Ser Thr Cys Lys His Lys Val Gly Asp Thr Glu 
    130                 135                 140                 


Gly Glu Tyr His Arg Ala Ser Ser Glu Asn Cys Tyr Ser Val Tyr Ala 
145                 150                 155                 160 


Asp Gln Val Asn Ile Asp Tyr Leu Met Asn Arg Pro Gln Asn Leu Arg 
                165                 170                 175     


Leu Glu Met Thr Ala Ala Lys Asn Thr Asn Asn Asn Gln Ser Pro Ser 
            180                 185                 190         


Ala Pro Pro Ala Lys Pro Pro Ser Thr Gln Arg Ala Val Ile Ser Pro 
        195                 200                 205             


Asp Gly Glu Cys Ser Ile Asp Asp Leu Ser Phe Tyr Val Asn Arg Leu 
    210                 215                 220                 


Ser Ser Leu Val Ile Gln Met Ala His Lys Glu Ile Lys Glu Lys Leu 
225                 230                 235                 240 


Glu Gly Lys Ser Lys Cys Leu His His Ser Ile Cys Pro Ser Pro Gly 
                245                 250                 255     


Asn Lys Glu Arg Ile Ser Pro Arg Thr Pro Ala Ser Lys Ile Ala Ser 
            260                 265                 270         


Glu Met Ala Tyr Glu Ala Val Glu Leu Thr Ala Ala Glu Met Arg Gly 
        275                 280                 285             


Thr Gly Glu Glu Ser Arg Glu Gly Gly Gln Lys Ser Phe Leu Tyr Ser 
    290                 295                 300                 


Glu Leu Ser Asn Lys Ser Lys Ser Gly Asp Lys Gln Met Ser Gln Arg 
305                 310                 315                 320 


Glu Ser Lys Glu Phe Ala Asp Ser Ile Ser Lys Gly Leu Met Val Tyr 
                325                 330                 335     


Ala Asn Gln Val Ala Ser Asp Met Met Val Ser Leu Met Lys Thr Leu 
            340                 345                 350         


Lys Val His Ser Ser Gly Lys Pro Ile Pro Ala Ser Val Val Leu Lys 
        355                 360                 365             


Arg Val Leu Leu Arg His Thr Lys Glu Ile Val Ser Asp Leu Ile Asp 
    370                 375                 380                 


Ser Cys Met Lys Asn Leu His Asn Ile Thr Gly Val Leu Met Thr Asp 
385                 390                 395                 400 


Ser Asp Phe Val Ser Ala Val Lys Arg Asn Leu Phe Asn Gln Trp Lys 
                405                 410                 415     


Gln Asn Ala Thr Asp Ile Met Glu Ala Met Leu Lys Arg Leu Val Ser 
            420                 425                 430         


Ala Leu Ile Gly Glu Glu Lys Glu Thr Lys Ser Gln Ser Leu Ser Tyr 
        435                 440                 445             


Ala Ser Leu Lys Ala Gly Ser His Asp Pro Lys Cys Arg Asn Gln Ser 
    450                 455                 460                 


Leu Glu Phe Ser Thr Met Lys Ala Glu Met Lys Glu Arg Asp Lys Gly 
465                 470                 475                 480 


Lys Met Lys Ser Asp Pro Cys Lys Ser Leu Thr Ser Ala Glu Lys Val 
                485                 490                 495     


Gly Glu His Ile Leu Lys Glu Gly Leu Thr Ile Trp Asn Gln Lys Gln 
            500                 505                 510         


Gly Asn Ser Cys Lys Val Ala Thr Lys Ala Cys Ser Asn Lys Asp Glu 
        515                 520                 525             


Lys Gly Glu Lys Ile Asn Ala Ser Thr Asp Ser Leu Ala Lys Asp Leu 
    530                 535                 540                 


Ile Val Ser Ala Leu Lys Leu Ile Gln Tyr His Leu Thr Gln Gln Thr 
545                 550                 555                 560 


Lys Gly Lys Asp Thr Cys Glu Glu Asp Cys Pro Gly Ser Thr Met Gly 
                565                 570                 575     


Tyr Met Ala Gln Ser Thr Gln Tyr Glu Lys Cys Gly Gly Gly Gln Ser 
            580                 585                 590         


Ala Lys Ala Leu Ser Val Lys Gln Leu Glu Ser His Arg Ala Pro Gly 
        595                 600                 605             


Pro Ser Thr Cys Gln Lys Glu Asn Gln His Leu Asp Ser Gln Lys Met 
    610                 615                 620                 


Asp Met Ser Asn Ile Val Leu Met Leu Ile Gln Lys Leu Leu Asn Glu 
625                 630                 635                 640 


Asn Pro Phe Lys Cys Glu Asp Pro Cys Glu Gly Glu Asn Lys Cys Ser 
                645                 650                 655     


Glu Pro Arg Ala Ser Lys Ala Ala Ser Met Ser Asn Arg Ser Asp Lys 
            660                 665                 670         


Ala Glu Glu Gln Cys Gln Glu His Gln Glu Leu Asp Cys Thr Ser Gly 
        675                 680                 685             


Met Lys Gln Ala Asn Gly Gln Phe Ile Asp Lys Leu Val Glu Ser Val 
    690                 695                 700                 


Met Lys Leu Cys Leu Ile Met Ala Lys Tyr Ser Asn Asp Gly Ala Ala 
705                 710                 715                 720 


Leu Ala Glu Leu Glu Glu Gln Ala Ala Ser Ala Asn Lys Pro Asn Phe 
                725                 730                 735     


Arg Gly Thr Arg Cys Ile His Ser Gly Ala Met Pro Gln Asn Tyr Gln 
            740                 745                 750         


Asp Ser Leu Gly His Glu Val Ile Val Asn Asn Gln Cys Ser Thr Asn 
        755                 760                 765             


Ser Leu Gln Lys Gln Leu Gln Ala Val Leu Gln Trp Ile Ala Ala Ser 
    770                 775                 780                 


Gln Phe Asn Val Pro Met Leu Tyr Phe Met Gly Asp Lys Asp Gly Gln 
785                 790                 795                 800 


Leu Glu Lys Leu Pro Gln Val Ser Ala Lys Ala Ala Glu Lys Gly Tyr 
                805                 810                 815     


Ser Val Gly Gly Leu Leu Gln Glu Val Met Lys Phe Ala Lys Glu Arg 
            820                 825                 830         


Gln Pro Asp Glu Ala Val Gly Lys Val Ala Arg Lys Gln Leu Leu Asp 
        835                 840                 845             


Trp Leu Leu Ala Asn Leu 
    850                 


<210>  170
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ser Asp Asp Ile Asp Trp Leu Arg Ser His Arg Gly Val Cys Lys 
1               5                   10                  15      


Val Asp Leu Tyr Asn Pro Glu Gly Gln Gln Asp Gln Asp Arg Lys Val 
            20                  25                  30          


Ile Cys Phe Val Asp Val Ser Thr Leu Asn Val Glu Asp Lys Asp Tyr 
        35                  40                  45              


Lys Asp Ala Ala Ser Ser Ser Ser Glu Gly Asn Leu Asn Leu Gly Ser 
    50                  55                  60                  


Leu Glu Glu Lys Glu Ile Ile Val Ile Lys Asp Thr Glu Lys Lys Asp 
65                  70                  75                  80  


Gln Ser Lys Thr Glu Gly Ser Val Cys Leu Phe Lys Gln Ala Pro Ser 
                85                  90                  95      


Asp Pro Val Ser Val Leu Asn Trp Leu Leu Ser Asp Leu Gln Lys Tyr 
            100                 105                 110         


Ala Leu Gly Phe Gln His Ala Leu Ser Pro Ser Thr Ser Thr Cys Lys 
        115                 120                 125             


His Lys Val Gly Asp Thr Glu Gly Glu Tyr His Arg Ala Ser Ser Glu 
    130                 135                 140                 


Asn Cys Tyr Ser Val Tyr Ala Asp Gln Val Asn Ile Asp Tyr Leu Met 
145                 150                 155                 160 


Asn Arg Pro Gln Asn Leu Arg Leu Glu Met Thr Ala Ala Lys Asn Thr 
                165                 170                 175     


Asn Asn Asn Gln Ser Pro Ser Ala Pro Pro Ala Lys Pro Pro Ser Thr 
            180                 185                 190         


Gln Arg Ala Val Ile Ser Pro Asp Gly Glu Cys Ser Ile Asp Asp Leu 
        195                 200                 205             


Ser Phe Tyr Val Asn Arg Leu Ser Ser Leu Val Ile Gln Met Ala His 
    210                 215                 220                 


Lys Glu Ile Lys Glu Lys Leu Glu Gly Lys Ser Lys Cys Leu His His 
225                 230                 235                 240 


Ser Ile Cys Pro Ser Pro Gly Asn Lys Glu Arg Ile Ser Pro Arg Thr 
                245                 250                 255     


Pro Ala Ser Lys Ile Ala Ser Glu Met Ala Tyr Glu Ala Val Glu Leu 
            260                 265                 270         


Thr Ala Ala Glu Met Arg Gly Thr Gly Glu Glu Ser Arg Glu Gly Gly 
        275                 280                 285             


Gln Lys Ser Phe Leu Tyr Ser Glu Leu Ser Asn Lys Ser Lys Ser Gly 
    290                 295                 300                 


Asp Lys Gln Met Ser Gln Arg Glu Ser Lys Glu Phe Ala Asp Ser Ile 
305                 310                 315                 320 


Ser Lys Gly Leu Met Val Tyr Ala Asn Gln Val Ala Ser Asp Met Met 
                325                 330                 335     


Val Ser Leu Met Lys Thr Leu Lys Val His Ser Ser Gly Lys Pro Ile 
            340                 345                 350         


Pro Ala Ser Val Val Leu Lys Arg Val Leu Leu Arg His Thr Lys Glu 
        355                 360                 365             


Ile Val Ser Asp Leu Ile Asp Ser Cys Met Lys Asn Leu His Asn Ile 
    370                 375                 380                 


Thr Gly Val Leu Met Thr Asp Ser Asp Phe Val Ser Ala Val Lys Arg 
385                 390                 395                 400 


Asn Leu Phe Asn Gln Trp Lys Gln Asn Ala Thr Asp Ile Met Glu Ala 
                405                 410                 415     


Met Leu Lys Arg Leu Val Ser Ala Leu Ile Gly Glu Glu Lys Glu Thr 
            420                 425                 430         


Lys Ser Gln Ser Leu Ser Tyr Ala Ser Leu Lys Ala Gly Ser His Asp 
        435                 440                 445             


Pro Lys Cys Arg Asn Gln Ser Leu Glu Phe Ser Thr Met Lys Ala Glu 
    450                 455                 460                 


Met Lys Glu Arg Asp Lys Gly Lys Met Lys Ser Asp Pro Cys Lys Ser 
465                 470                 475                 480 


Leu Thr Ser Ala Glu Lys Val Gly Glu His Ile Leu Lys Glu Gly Leu 
                485                 490                 495     


Thr Ile Trp Asn Gln Lys Gln Gly Asn Ser Cys Lys Val Ala Thr Lys 
            500                 505                 510         


Ala Cys Ser Asn Lys Asp Glu Lys Gly Glu Lys Ile Asn Ala Ser Thr 
        515                 520                 525             


Asp Ser Leu Ala Lys Asp Leu Ile Val Ser Ala Leu Lys Leu Ile Gln 
    530                 535                 540                 


Tyr His Leu Thr Gln Gln Thr Lys Gly Lys Asp Thr Cys Glu Glu Asp 
545                 550                 555                 560 


Cys Pro Gly Ser Thr Met Gly Tyr Met Ala Gln Ser Thr Gln Tyr Glu 
                565                 570                 575     


Lys Cys Gly Gly Gly Gln Ser Ala Lys Ala Leu Ser Val Lys Gln Leu 
            580                 585                 590         


Glu Ser His Arg Ala Pro Gly Pro Ser Thr Cys Gln Lys Glu Asn Gln 
        595                 600                 605             


His Leu Asp Ser Gln Lys Met Asp Met Ser Asn Ile Val Leu Met Leu 
    610                 615                 620                 


Ile Gln Lys Leu Leu Asn Glu Asn Pro Phe Lys Cys Glu Asp Pro Cys 
625                 630                 635                 640 


Glu Gly Glu Asn Lys Cys Ser Glu Pro Arg Ala Ser Lys Ala Ala Ser 
                645                 650                 655     


Met Ser Asn Arg Ser Asp Lys Ala Glu Glu Gln Cys Gln Glu His Gln 
            660                 665                 670         


Glu Leu Asp Cys Thr Ser Gly Met Lys Gln Ala Asn Gly Gln Phe Ile 
        675                 680                 685             


Asp Lys Leu Val Glu Ser Val Met Lys Leu Cys Leu Ile Met Ala Lys 
    690                 695                 700                 


Tyr Ser Asn Asp Gly Ala Ala Leu Ala Glu Leu Glu Glu Gln Ala Ala 
705                 710                 715                 720 


Ser Ala Asn Lys Pro Asn Phe Arg Gly Thr Arg Cys Ile His Ser Gly 
                725                 730                 735     


Ala Met Pro Gln Asn Tyr Gln Asp Ser Leu Gly His Glu Val Ile Val 
            740                 745                 750         


Asn Asn Gln Cys Ser Thr Asn Ser Leu Gln Lys Gln Leu Gln Ala Val 
        755                 760                 765             


Leu Gln Trp Ile Ala Ala Ser Gln Phe Asn Val Pro Met Leu Tyr Phe 
    770                 775                 780                 


Met Gly Asp Lys Asp Gly Gln Leu Glu Lys Leu Pro Gln Val Ser Ala 
785                 790                 795                 800 


Lys Ala Ala Glu Lys Gly Tyr Ser Val Gly Gly Leu Leu Gln Glu Val 
                805                 810                 815     


Met Lys Phe Ala Lys Glu Arg Gln Pro Asp Glu Ala Val Gly Lys Val 
            820                 825                 830         


Ala Arg Lys Gln Leu Leu Asp Trp Leu Leu Ala Asn Leu 
        835                 840                 845 


<210>  171
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  172
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg 
1               5                   10                  15      


Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly 
            20                  25                  30          


Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile 
        35                  40                  45              


Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu 
    50                  55                  60                  


Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala 
65                  70                  75                  80  


Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe 
                85                  90                  95      


Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val 
            100                 105                 110         


Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu 
        115                 120                 125             


Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg 
    130                 135                 140                 


Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His 
145                 150                 155                 160 


Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His 
                165                 170                 175     


Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro 
            180                 185                 190         


Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp 
        195                 200                 205             


Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro 
    210                 215                 220                 


Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser 
225                 230                 235                 240 


Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser 
                245                 250                 255     


Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu 
            260                 265                 270         


Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly 
        275                 280                 285             


Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp 
    290                 295                 300                 


Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln 
305                 310                 315                 320 


Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu 
                325                 330                 335     


Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly 
            340                 345                 350         


Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg 
        355                 360                 365             


Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala 
    370                 375                 380                 


Ala Lys Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val Pro Arg Gly 
385                 390                 395                 400 


Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn 
                405                 410                 415     


Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr 
            420                 425                 430         


Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr 
        435                 440                 445             


Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn 
    450                 455                 460                 


Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly 
465                 470                 475                 480 


Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala 
                485                 490                 495     


Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly 
            500                 505                 510         


Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala 
        515                 520                 525             


Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys 
    530                 535                 540                 


Asn Ser Met Asn Gln Pro Gly Pro 
545                 550         


<210>  173
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr 
            260                 265                 270         


Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 
        275                 280                 285             


Lys Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn 
    290                 295                 300                 


Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 
    370                 375                 380                 


Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 
    450                 455                 460                 


Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     


<210>  174
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Lys Asp Pro Thr Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser 
    290                 295                 300                 


Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala 
        435                 440                 445             


Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn 
    450                 455                 460                 


Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly 
465                 470                 475                 480 


Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495 


<210>  175
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu Leu Glu His Ser 
            100                 105                 110         


Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp Gln Thr Ser Glu 
        115                 120                 125             


Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu Lys Lys Val Leu 
    130                 135                 140                 


Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser Ile Lys Glu Glu 
145                 150                 155                 160 


Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn Ser Ile Ile Glu 
                165                 170                 175     


Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn Asn Ser Val Leu 
            180                 185                 190         


Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn Asn Leu Leu Thr 
        195                 200                 205             


Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr Val Ala Lys Glu 
    210                 215                 220                 


Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His 
225                 230                 235                 240 


Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu 
                245                 250                 255     


Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile 
            260                 265                 270         


Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys 
        275                 280                 285             


Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly 
    290                 295                 300                 


Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys 
305                 310                 315                 320 


Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu 
                325                 330                 335     


His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys 
            340                 345                 350         


Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly 
        355                 360                 365             


Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys 
    370                 375                 380                 


Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro 
385                 390                 395                 400 


Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys 
                405                 410                 415     


Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu 
            420                 425                 430         


Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
        435                 440                 


<210>  176
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu 
        115                 120                 125             


Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys 
    130                 135                 140                 


Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr 
    210                 215                 220                 


Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Gly Val Leu Leu 
            260                 265                 270         


Lys Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp 
        275                 280                 285             


Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile 
    290                 295                 300                 


Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn 
305                 310                 315                 320 


Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp 
                325                 330                 335     


Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser 
            340                 345                 350         


Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln 
        355                 360                 365             


Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg 
    370                 375                 380                 


Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn 
385                 390                 395                 400 


Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser 
                405                 410                 415     


Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn 
            420                 425                 430         


Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp 
        435                 440                 445             


Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala 
    450                 455                 460                 


Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys 
465                 470                 475                 480 


Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu 
                485                 490                 495     


Asp Phe 
        


<210>  177
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Thr Val Phe Leu Ser Phe Ala Phe Leu Ala Ala Ile Leu Thr His 
1               5                   10                  15      


Ile Gly Cys Ser Asn Gln Arg Arg Ser Pro Glu Asn Ser Gly Arg Arg 
            20                  25                  30          


Tyr Asn Arg Ile Gln His Gly Gln Cys Ala Tyr Thr Phe Ile Leu Pro 
        35                  40                  45              


Glu His Asp Gly Asn Cys Arg Glu Ser Thr Thr Asp Gln Tyr Asn Thr 
    50                  55                  60                  


Asn Ala Leu Gln Arg Asp Ala Pro His Val Glu Pro Asp Phe Ser Ser 
65                  70                  75                  80  


Gln Lys Leu Gln His Leu Glu His Val Met Glu Asn Tyr Thr Gln Trp 
                85                  90                  95      


Leu Gln Lys Leu Glu Asn Tyr Ile Val Glu Asn Met Lys Ser Glu Met 
            100                 105                 110         


Ala Gln Ile Gln Gln Asn Ala Val Gln Asn His Thr Ala Thr Met Leu 
        115                 120                 125             


Glu Ile Gly Thr Ser Leu Leu Ser Gln Thr Ala Glu Gln Thr Arg Lys 
    130                 135                 140                 


Leu Thr Asp Val Glu Thr Gln Val Leu Asn Gln Thr Ser Arg Leu Glu 
145                 150                 155                 160 


Ile Gln Leu Leu Glu Asn Ser Leu Ser Thr Tyr Lys Leu Glu Lys Gln 
                165                 170                 175     


Leu Leu Gln Gln Thr Asn Glu Ile Leu Lys Ile His Glu Lys Asn Ser 
            180                 185                 190         


Leu Leu Glu His Lys Ile Leu Glu Met Glu Gly Lys His Lys Glu Glu 
        195                 200                 205             


Leu Asp Thr Leu Lys Glu Glu Lys Glu Asn Leu Gln Gly Leu Val Thr 
    210                 215                 220                 


Arg Gln Thr Tyr Ile Ile Gln Glu Leu Glu Lys Gln Leu Asn Arg Ala 
225                 230                 235                 240 


Thr Thr Asn Asn Ser Val Leu Gln Lys Gln Gln Leu Glu Leu Met Asp 
                245                 250                 255     


Thr Val His Asn Leu Val Asn Leu Cys Thr Lys Glu Val Leu Leu Lys 
            260                 265                 270         


Gly Gly Lys Arg Glu Glu Glu Lys Pro Phe Arg Asp Cys Ala Asp Val 
        275                 280                 285             


Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn 
    290                 295                 300                 


Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly 
305                 310                 315                 320 


Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe 
                325                 330                 335     


Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly 
            340                 345                 350         


Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg 
        355                 360                 365             


Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala 
    370                 375                 380                 


Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr 
385                 390                 395                 400 


Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser 
                405                 410                 415     


Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp 
            420                 425                 430         


Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe 
        435                 440                 445             


Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly 
    450                 455                 460                 


Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly 
465                 470                 475                 480 


Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp 
                485                 490                 495     


Phe 
    


<210>  178
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Glu Gly Lys His Lys Glu Glu Leu Asp Thr Leu Lys Glu Glu Lys 
1               5                   10                  15      


Glu Asn Leu Gln Gly Leu Val Thr Arg Gln Thr Tyr Ile Ile Gln Glu 
            20                  25                  30          


Leu Glu Lys Gln Leu Asn Arg Ala Thr Thr Asn Asn Ser Val Leu Gln 
        35                  40                  45              


Lys Gln Gln Leu Glu Leu Met Asp Thr Val His Asn Leu Val Asn Leu 
    50                  55                  60                  


Cys Thr Lys Glu Gly Val Leu Leu Lys Gly Gly Lys Arg Glu Glu Glu 
65                  70                  75                  80  


Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys 
                85                  90                  95      


Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys 
            100                 105                 110         


Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln 
        115                 120                 125             


His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr 
    130                 135                 140                 


Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
145                 150                 155                 160 


Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu 
                165                 170                 175     


Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe 
            180                 185                 190         


His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His 
        195                 200                 205             


Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp 
    210                 215                 220                 


Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala 
225                 230                 235                 240 


Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                245                 250                 255     


Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn 
            260                 265                 270         


Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser 
        275                 280                 285             


Thr Thr Met Met Ile Arg Pro Leu Asp Phe 
    290                 295             


<210>  179
<211>  1341
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Thr Lys Arg Lys Lys Thr Ile Asn Leu Asn Ile Gln Asp Ala Gln 
1               5                   10                  15      


Lys Arg Thr Ala Leu His Trp Ala Cys Val Asn Gly His Glu Glu Val 
            20                  25                  30          


Val Thr Phe Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly 
        35                  40                  45              


Glu His Arg Thr Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala 
    50                  55                  60                  


Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp 
65                  70                  75                  80  


Val Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu 
                85                  90                  95      


Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His 
            100                 105                 110         


Asn Lys Ala Ser Leu Thr Pro Leu Leu Leu Ser Ile Thr Lys Arg Ser 
        115                 120                 125             


Glu Gln Ile Val Glu Phe Leu Leu Ile Lys Asn Ala Asn Ala Asn Ala 
    130                 135                 140                 


Val Asn Lys Tyr Lys Cys Thr Ala Leu Met Leu Ala Val Cys His Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe 
                165                 170                 175     


Ala Ala Asp Ile Cys Gly Val Thr Ala Glu His Tyr Ala Val Thr Cys 
            180                 185                 190         


Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu 
        195                 200                 205             


Ser Lys Asn His Gln Asn Thr Asn Pro Glu Gly Thr Ser Ala Gly Thr 
    210                 215                 220                 


Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu 
225                 230                 235                 240 


Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala Pro Leu Val Glu Arg 
                245                 250                 255     


Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala 
            260                 265                 270         


Ala Ser Leu Val Glu Gly Thr Ser Asp Lys Ile Gln Cys Leu Glu Lys 
        275                 280                 285             


Ala Thr Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Thr Pro Arg Glu 
    290                 295                 300                 


Ile Thr Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp Pro Ala 
305                 310                 315                 320 


Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Thr Pro 
                325                 330                 335     


Arg Glu Ile Met Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp 
            340                 345                 350         


Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Thr 
        355                 360                 365             


Pro Val Lys Thr Gly Cys Val Ala Arg Val Thr Ser Asn Lys Thr Lys 
    370                 375                 380                 


Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Thr Lys Glu 
385                 390                 395                 400 


Ser Ser Thr Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser 
                405                 410                 415     


Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe 
            420                 425                 430         


Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln 
        435                 440                 445             


Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro 
    450                 455                 460                 


Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys 
465                 470                 475                 480 


Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Pro Met Phe 
                485                 490                 495     


Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser 
            500                 505                 510         


Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys 
        515                 520                 525             


Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu 
    530                 535                 540                 


Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Thr Cys Gly Met Lys Val 
545                 550                 555                 560 


Ser Ile Pro Thr Lys Ala Leu Glu Leu Lys Asp Met Gln Thr Phe Lys 
                565                 570                 575     


Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Thr Glu Met 
            580                 585                 590         


Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr 
        595                 600                 605             


Leu Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr 
    610                 615                 620                 


Glu Glu Asn Ser Trp Asp Thr Glu Ser Leu Cys Glu Thr Val Ser Gln 
625                 630                 635                 640 


Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys 
                645                 650                 655     


Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys 
            660                 665                 670         


Ala Asn Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu 
        675                 680                 685             


Met Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala 
    690                 695                 700                 


Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu 
705                 710                 715                 720 


Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Glu Ile Leu Pro Ser 
                725                 730                 735     


Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser 
            740                 745                 750         


Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Thr 
        755                 760                 765             


His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro 
    770                 775                 780                 


Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg Met Lys Val Ser Ile 
785                 790                 795                 800 


Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala Glu 
                805                 810                 815     


Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys 
            820                 825                 830         


Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg 
        835                 840                 845             


Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Lys Val Glu Glu 
    850                 855                 860                 


Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Thr Val Ser Gln Lys Asp 
865                 870                 875                 880 


Val Cys Val Pro Lys Ala Thr His Gln Lys Glu Met Asp Lys Ile Ser 
                885                 890                 895     


Gly Lys Leu Glu Asp Ser Thr Ser Leu Ser Lys Ile Leu Asp Thr Val 
            900                 905                 910         


His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys Asp His Cys Glu Gln 
        915                 920                 925             


Arg Thr Gly Lys Met Glu Gln Met Lys Lys Lys Phe Cys Val Leu Lys 
    930                 935                 940                 


Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln 
945                 950                 955                 960 


Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Thr Leu Asn 
                965                 970                 975     


Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile Leu Asn Glu Lys Ile 
            980                 985                 990         


Arg Glu Glu Leu Gly Arg Ile Glu  Glu Gln His Arg Lys  Glu Leu Glu 
        995                 1000                 1005             


Val Lys  Gln Gln Leu Glu Gln  Ala Leu Arg Ile Gln  Asp Ile Glu 
    1010                 1015                 1020             


Leu Lys  Ser Val Glu Ser Asn  Leu Asn Gln Val Ser  His Thr His 
    1025                 1030                 1035             


Glu Asn  Glu Asn Tyr Leu Leu  His Glu Asn Cys Met  Leu Lys Lys 
    1040                 1045                 1050             


Glu Ile  Ala Met Leu Lys Leu  Glu Ile Ala Thr Leu  Lys His Gln 
    1055                 1060                 1065             


Tyr Gln  Glu Lys Glu Asn Lys  Tyr Phe Glu Asp Ile  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Lys Asn Ala Glu Leu  Gln Met Thr Leu Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Ser  Leu Thr Lys Arg Ala  Ser Gln Tyr Ser Gly  Gln Leu Lys 
    1100                 1105                 1110             


Val Leu  Ile Ala Glu Asn Thr  Met Leu Thr Ser Lys  Leu Lys Glu 
    1115                 1120                 1125             


Lys Gln  Asp Lys Glu Ile Leu  Glu Ala Glu Ile Glu  Ser His His 
    1130                 1135                 1140             


Pro Arg  Leu Ala Ser Ala Val  Gln Asp His Asp Gln  Ile Val Thr 
    1145                 1150                 1155             


Ser Arg  Lys Ser Gln Glu Pro  Ala Phe His Ile Ala  Gly Asp Ala 
    1160                 1165                 1170             


Cys Leu  Gln Arg Lys Met Asn  Val Asp Val Ser Ser  Thr Ile Tyr 
    1175                 1180                 1185             


Asn Asn  Glu Val Leu His Gln  Pro Leu Ser Glu Ala  Gln Arg Lys 
    1190                 1195                 1200             


Ser Lys  Ser Leu Lys Ile Asn  Leu Asn Tyr Ala Gly  Asp Ala Leu 
    1205                 1210                 1215             


Arg Glu  Asn Thr Leu Val Ser  Glu His Ala Gln Arg  Asp Gln Arg 
    1220                 1225                 1230             


Glu Thr  Gln Cys Gln Met Lys  Glu Ala Glu His Met  Tyr Gln Asn 
    1235                 1240                 1245             


Glu Gln  Asp Asn Val Asn Lys  His Thr Glu Gln Gln  Glu Ser Leu 
    1250                 1255                 1260             


Asp Gln  Lys Leu Phe Gln Leu  Gln Ser Lys Asn Met  Trp Leu Gln 
    1265                 1270                 1275             


Gln Gln  Leu Val His Ala His  Lys Lys Ala Asp Asn  Lys Ser Lys 
    1280                 1285                 1290             


Ile Thr  Ile Asp Ile His Phe  Leu Glu Arg Lys Met  Gln His His 
    1295                 1300                 1305             


Leu Leu  Lys Glu Lys Asn Glu  Glu Ile Phe Asn Tyr  Asn Asn His 
    1310                 1315                 1320             


Leu Lys  Asn Arg Ile Tyr Gln  Tyr Glu Lys Glu Lys  Ala Glu Thr 
    1325                 1330                 1335             


Glu Asn  Ser 
    1340     


<210>  180
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  181
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ile Leu Trp Leu His Ser Leu Glu Thr Ala Arg Asp His Val Leu 
1               5                   10                  15      


Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly 
            20                  25                  30          


Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys 
        35                  40                  45              


Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys 
    50                  55                  60                  


Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys 
65                  70                  75                  80  


Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly 
                85                  90                  95      


Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly 
            100                 105                 110         


Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys Leu 
        115                 120                 125             


Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn 
    130                 135                 140                 


Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn 
145                 150                 155                 160 


Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu 
                165                 170                 175     


Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro 
            180                 185                 190         


Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr 
        195                 200                 205             


Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr 
    210                 215                 220                 


Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn 
225                 230                 235                 240 


Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met 
                245                 250                 255     


Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu 
            260                 265                 270         


Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp 
        275                 280                 285             


Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile 
    290                 295                 300                 


Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser 
305                 310                 315                 320 


Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln 
                325                 330                 335     


Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys 
            340                 345                 350         


Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile 
        355                 360                 365             


Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr 
    370                 375                 380                 


Phe His Thr Gln 
385             


<210>  182
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Glu Lys Phe Arg Val Gly Asn Cys Lys His Leu Lys 
625                 630                 635                 640 


Met Thr Arg Pro 
                


<210>  183
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Ala Val Val Val Ser Glu Arg Ile Leu Arg Val 
625                 630                 635                 640 


Phe Gly Val Ser Glu Trp Leu Pro 
                645             


<210>  184
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Asn Thr Arg Arg Lys 
    530                 535                 540                 


Arg Leu Trp Lys Leu Ile Ile Arg Ser Ile Asn Ser Cys Ile Cys Ser 
545                 550                 555                 560 


Pro Arg Glu Thr Glu Val Pro Val Arg Gln Gln Lys 
                565                 570         


<210>  185
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Thr Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Thr Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Thr Gly Asn Asp Glu Val Ile Gly Gln Val Leu Ser 
        195                 200                 205             


Thr Leu Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu Thr Ala Val 
    210                 215                 220                 


Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala Gly Gly Leu 
225                 230                 235                 240 


Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val Ile His Pro 
                245                 250                 255     


Pro Val Ser Tyr Asn Asp Thr Ala Pro Arg Ile Leu Phe Trp Ala Gln 
            260                 265                 270         


Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu Thr Pro Leu 
        275                 280                 285             


Thr Phe Gly Val Gln Glu Leu Asn Leu Thr Gly Ser Phe Trp Asn Asp 
    290                 295                 300                 


Ser Phe Ala Arg Leu Ser Leu Thr Tyr Glu Arg Leu Phe Gly Thr Thr 
305                 310                 315                 320 


Val Thr Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala 
                325                 330                 335     


Arg His Trp Phe Thr Met Glu Arg Leu Glu Val His Ser Asn Gly Ser 
            340                 345                 350         


Val Ala Tyr Phe Asn Ala Ser Gln Val Thr Gly Pro Ser Ile Tyr Ser 
        355                 360                 365             


Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly Ser Leu Leu 
    370                 375                 380                 


Val Ala Arg Thr Gln Pro Ser Pro Trp Gln Met Met Leu Gln Asp Phe 
385                 390                 395                 400 


Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser Tyr Ala Ser 
                405                 410                 415     


Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly Leu Leu Thr 
            420                 425                 430         


Ser Leu Phe Met Leu Phe Ile Phe Thr Tyr Gly Leu His Met Ile Leu 
        435                 440                 445             


Ser Leu Lys Thr Met Asp Arg Phe Asp Asp His Lys Gly Pro Thr Ile 
    450                 455                 460                 


Ser Leu Thr Gln Ile Val 
465                 470 


<210>  186
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Ala Arg Ala Val Phe Leu Ala Leu Ser Ala Gln Leu Leu Gln 
1               5                   10                  15      


Ala Arg Leu Met Lys Glu Glu Ser Pro Val Val Ser Trp Arg Leu Glu 
            20                  25                  30          


Pro Glu Asp Gly Thr Ala Leu Cys Phe Ile Phe 
        35                  40              


<210>  187
<211>  2978
<212>  DNA
<213>  Homo sapiens

<400>  187
gcacctgcag ggagggcagg cagctagcct gaaggctgat ccccccttcc tgttagcact       60

tttgatggga ctagtggact ttggttcaga aggaagagct atgcttgtta gggcctcttg      120

tctcctccca ggagtggaca aggtgggtta ggagcagttt ctccctgagt ggctgctgct      180

gggtggttga ggagatgcac ggcttctgtt cctagtcaca aggctgcagc agacgctcct      240

cagatgctct gtgccttgga tctggcccca ctcccgtcct cccagccctc ctctcctcca      300

gctacctgcc agccggcact tttggtcaag ctgttttgca ttcactgttg cacatatgct      360

cagtcacaca cacagcatac gctatgcaca tgtgtccaca cacaccccac ccacatccca      420

catcaccccg accccctctg ctgtccttgg aaccttatta cacttcgagt cactggtttg      480

cctgtattgt gaaaccagct ggatcctgag atccccaaga cagaaatcat gatgagtatg      540

tttttggccc atgacactgg cttaccttgt gccaggcaga tggcagccac acagtgtcca      600

ccggatggtt gattttgaag cagagttagc ttgtcacctg cctccctttc ccgggacaac      660

agaagctgac ctctttgatc tcttgcgcag atgatgagtc tccggggctc tatgggtttc      720

tgaatgtcat cgtccactca gccactggat ttaagcagag ttcaagtaag tactggtttg      780

gggaggaggg ttgcagcggc cgagccaggg tctccaccca ggaaggactc atcgggcagg      840

gtgtggggaa acagggaggt tgttcagatg accacgggac acctttgacc ctggccgctg      900

tggagtgttt gtgctggttg atgccttctg ggtgtggaat tgtttttccc ggagtggcct      960

ctgccctctc ccctagcctg tctcagatcc tgggagctgg tgagctgccc cctgcaggtg     1020

gatcgagtaa ttgcaggggt ttggcaagga ctttgacaga catccccagg ggtgcccggg     1080

agtgtggggt ccaagccagg agggctgtca gcagtgcacc ttcaccccac agcagagcag     1140

atttggctgc tctgtcgagc tggatggata ctactttttt tttcctttcc ctctaagtgg     1200

gggtctcccc cagctactgg agctgtcaga acagtgaagg ctggtaacac atgagttgca     1260

ctgtgtaagt ttctcgaggc cgggcgcagt ggctcatgcc tgtaatccca gcactttggg     1320

aggctgaggc aggtggatcg cttgagctca ggagttggag accagcctga ccaacatggt     1380

gaaaccctgt gtctactaaa aatacaaaga ttagccgggc taggcagtgg gcacctgtaa     1440

tcacaactgc ttgggaggct gagggaagag aatcgcttga acccaggagg cggaggttgc     1500

agtgagccga gcttgtgcca ctgcattcca gcctgggcga cagagcaaga ctccgcctca     1560

aaaaaaaaaa aaaaaagttc ctagaaacag caaaatgtgg agacagaaag cttaccaggg     1620

attgttgggg aatggggttg ggagagagga ctaactgcag atgaacccaa gggggacttt     1680

ttaggtgaga gcagtgtcgt gaaaagactg tggtgctgtt tgcgctcaca tttacatttc     1740

ctaaaattct ttaaacccta cacttggaat ggatgaatta catgacatgc agattgcacc     1800

ttcataacat aatctttctc ctgggcccct gtctctggct gcctcataaa cgctggtgtt     1860

tccctcgtgg gcctccctgc atccctgcat ctcctcccgg gtcctgtctg tgagcaatac     1920

agcgtgacac cctacgctgc cccgtggtcc cgggcttgtc tctccttgcc tccctgttac     1980

ctttctttct atctcttcct tgccccgtgc actcaacctt gcatccccaa accaaaccta     2040

ttattcatgg accccaaact tgttcctctt atgtcctgtc cctttgaggg gcaccaccat     2100

ccacccgcat ggccaagcca gaaaccgtgg tctgctctcc ctccgttaaa tgccattctc     2160

catcagtgag gcttcttagt catctctggc tgcctggcca ggccctggct gtggcctcct     2220

ccctggtctt tgtagctctg gatatccctg cagaaagggt ccccactacc aggcctctcc     2280

atccccagtc tcaggtagtt tttctaaaat gcaaacccca ccctgcaact taccgcccac     2340

agcccagccc actcttctcc aggcctcgcc tccctccctt ccccctgcac cccacgactt     2400

ctccagcact gagctgcttc ctgtgcccca cagtggcctg gagtcccctt tgccttaact     2460

ctttgcccca tagtacagcg gggtctgctc tgattgtagg ggcttcccac atcccccagg     2520

atggctgccc tctgctgtgg catcactgtg taacaatggc gtgtacacct ctctgtcccc     2580

accagtgcag ggcccttctc atcgtagggg ctttagctgg ggtttgtgga tcgactgagt     2640

gaacgaatgt tgtgggaagt cccgtttccc agccgcaccc agggaaattc cacagagcgg     2700

gcaggggcat cgcatgaggt gctggtgttc acgccagacc acaattaggt gtttaatttt     2760

taaaaagaaa gttacaacct ttttttttta tttttatttt ttctgattct gcaaataaca     2820

cctgctctta cagaccatgt gggtgatgtg gaaaagacct gtgaccttct ccatgtccac     2880

ttctccccac agatctgtac tgcaccctgg aggtggattc ctttgggtat tttgtgaata     2940

aagcaaagac gcgcgtctac agggacacag ctgagcca                             2978


<210>  188
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  189
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Glu Phe Ala Ala Phe Lys 
        755                 760                 765         


<210>  190
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  191
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr 
    210                 215                 220                 


Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Thr Lys His Met Thr Val 
385                 390                 395                 400 


Lys Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro 
                405                 410                 415     


Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys 
            420                 425                 430         


Val 
    


<210>  192
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr 
    210                 215                 220                 


Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Val Lys Asn Lys Tyr Ala 
        355                 360                 365             


Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro Gln Leu Asn Ser Ala 
    370                 375                 380                 


Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys Val 
385                 390                 395     


<210>  193
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Asn Asn Cys Val Pro Lys Lys Met Leu Gln 
            180                 185                 190         


Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser Lys Tyr Glu Glu Met 
        195                 200                 205             


Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val Thr Asp Asn Thr Tyr 
    210                 215                 220                 


Thr Lys His Gln Ile Arg Gln Met Glu Met Lys Ile Leu Arg Ala Leu 
225                 230                 235                 240 


Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His Phe Leu Arg Arg Ala 
                245                 250                 255     


Ser Lys Ile Gly Glu Val Asp Val Glu Gln His Thr Leu Ala Lys Tyr 
            260                 265                 270         


Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met Val His Phe Pro Pro 
        275                 280                 285             


Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala Leu Lys Ile Leu Asp 
    290                 295                 300                 


Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr Leu Ser Tyr Thr Glu 
305                 310                 315                 320 


Glu Ser Leu Leu Pro Val Met Gln His Leu Ala Lys Asn Val Val Met 
                325                 330                 335     


Val Asn Gln Gly Leu Thr Lys His Met Thr Val Lys Asn Lys Tyr Ala 
            340                 345                 350         


Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro Gln Leu Asn Ser Ala 
        355                 360                 365             


Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys Val 
    370                 375                 380 


<210>  194
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  195
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  196
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
1               5                   10                  15      


Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp 
            20                  25                  30          


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
        35                  40                  45              


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu Arg Val 
    50                  55                  60                  


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
65                  70                  75                  80  


Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln Arg Ser 
                85                  90                  95      


Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val Val Ala 
            100                 105                 110         


Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro Glu Pro 
        115                 120                 125             


Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr 
    130                 135                 140                 


Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly Ser Ala 
145                 150                 155                 160 


Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn 
                165                 170                 175     


Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe 
            180                 185                 190         


Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu 
        195                 200                 205             


Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn 
    210                 215                 220                 


Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr 
225                 230                 235                 240 


Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val 
                245                 250                 255     


Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly 
            260                 265                 270         


Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly 
        275                 280                 285             


Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His 
    290                 295                 300                 


Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu Ala 
305                 310                 315                 320 


Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val 
                325                 330                 335     


Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu 
            340                 345                 350         


Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys 
        355                 360                 365             


Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly 
    370                 375                 380                 


Gln Glu Ile Ala 
385             


<210>  197
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 
            180                 185                 190         


Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 
        195                 200                 205             


Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 
    210                 215                 220                 


Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 
225                 230                 235                 240 


Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 
                245                 250         


<210>  198
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Pro Trp Ser Leu Pro Gln Leu Cys Leu Leu Asp 
            180                 185                 190         


Val Pro Ser Leu His Cys Pro Gly Pro Pro Thr Gln Pro Gln Asp Ser 
        195                 200                 205             


Ser Phe His Leu 
    210         


<210>  199
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  200
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Glu 
305                 310                 315                 320 


Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp 
                325                 330                 335     


Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr 
            340                 345                 350         


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu 
        355                 360                 365             


Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg 
    370                 375                 380                 


Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val 
385                 390                 395                 400 


Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp 
                405                 410                 415     


Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu 
            420                 425                 430         


Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp 
        435                 440                 445             


Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser 
    450                 455                 460                 


Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn 
465                 470                 475                 480 


Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser 
                485                 490                 495     


Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val 
            500                 505                 510         


Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn 
        515                 520                 525             


Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro 
    530                 535                 540                 


Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val 
545                 550                 555                 560 


Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val 
                565                 570                 575     


Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro 
            580                 585                 590         


Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala 
        595                 600                 605             


Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr 
    610                 615                 620                 


Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe 
625                 630                 635                 640 


Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val 
                645                 650                 655     


Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr 
            660                 665                 670         


Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val 
        675                 680                 685             


Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700     


<210>  201
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  201

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  202
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
1               5                   10                  15      


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
            20                  25                  30          


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly Asp 
        35                  40                  45              


Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe Ile 
    50                  55                  60                  


Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr Ser 
65                  70                  75                  80  


Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu His 
                85                  90                  95      


Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro Leu 
            100                 105                 110         


Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro Tyr 
        115                 120                 125             


Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His Met 
    130                 135                 140                 


Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly Phe 
145                 150                 155                 160 


Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly Gly 
                165                 170                 175     


Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His Arg 
            180                 185                 190         


Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr Leu 
        195                 200                 205             


Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg Met 
    210                 215                 220                 


Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu Gln 
225                 230                 235                 240 


Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val Lys 
                245                 250                 255     


Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp Asp 
            260                 265                 270         


Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu Ile 
        275                 280                 285             


Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr Pro 
    290                 295                 300                 


His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu Glu 
305                 310                 315                 320 


Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser Ser 
                325                 330                 335     


Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu Glu 
            340                 345                 350         


Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys Ile 
        355                 360                 365             


Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser Ala 
    370                 375                 380                 


Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys Gln 
385                 390                 395                 400 


Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn Arg 
                405                 410                 415     


Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp Asn 
            420                 425                 430         


Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile Lys 
        435                 440                 445             


Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr Ile 
    450                 455                 460                 


Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu Lys 
465                 470                 475                 480 


Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn Met 
                485                 490                 495     


Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu Gln 
            500                 505                 510         


Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp Lys 
        515                 520                 525             


Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys Gln 
    530                 535                 540                 


Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile Ile 
545                 550                 555                 560 


Lys Gly Thr Val Arg Thr Phe Leu Ser 
                565                 


<210>  203
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Trp Met Gly Leu Ile Gln Leu Val Glu Gly Val Lys Arg Lys Asp 
1               5                   10                  15      


Gln Gly Phe Leu Glu Lys Glu Phe Tyr His Lys Thr Asn Ile Lys Met 
            20                  25                  30          


Arg Cys Glu Phe Leu Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
        35                  40                  45              


Ala Trp Arg Asp Gln Val Asp Trp Ser Arg Leu Leu Arg Asp Thr Gly 
    50                  55                  60                  


Leu Val Lys Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Leu Ser Asn 
65                  70                  75                  80  


Asn His Pro Pro Thr Pro Lys Arg Arg Gly Ser Gly Arg His Pro Leu 
                85                  90                  95      


Asn Pro Gly Pro Glu Ala Leu Ser Lys Phe Pro Arg Gln Pro Gly Arg 
            100                 105                 110         


Glu Lys Gly Pro Ile Lys Glu Val Pro Gly Thr Lys Gly Ser Pro 
        115                 120                 125         


<210>  204
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Trp Met Gly Leu Ile Gln Leu Val Glu Gly Val Lys Arg Lys Asp 
1               5                   10                  15      


Gln Gly Phe Leu Glu Lys Glu Phe Tyr His Lys Thr Asn Ile Lys Met 
            20                  25                  30          


Arg Cys Glu Phe Leu Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
        35                  40                  45              


Ala Trp Arg Asp Gln Val Asp Trp Ser Arg Leu Leu Arg Asp Thr Gly 
    50                  55                  60                  


Leu Val Lys Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Leu Ser Asn 
65                  70                  75                  80  


Asn His Pro Pro Thr Pro Lys Arg Phe Pro Arg Gln Pro Gly Arg Glu 
                85                  90                  95      


Lys Gly Pro Ile Lys Glu Val Pro Gly Thr Lys Gly Ser Pro 
            100                 105                 110 


<210>  205
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  206
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Glu Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Ala Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  207
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Glu Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Met Ser Val Arg Asp Gln Asp Arg Glu Gly 
    130                 135                 140                 


Ala Gly Arg Met Arg Val Val Gly Trp Gly Leu Gly Ser Ala Ser Pro 
145                 150                 155                 160 


Glu Gly Gln Lys Ala Arg Asp Leu Arg Thr Pro Lys His Lys Val Ser 
                165                 170                 175     


Glu Gln Arg Pro Gly Thr Pro Gly Pro Pro Pro Pro Glu Gly Ala Gln 
            180                 185                 190         


Gly Asp Gly Cys Arg Gly Val Ala Phe Asn Val Met Phe Ser Ala Pro 
        195                 200                 205             


His Ile 
    210 


<210>  208
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr 
625                 630                 635                 640 


Thr Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Thr Met Asp Lys 
            660             


<210>  209
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys Gly 
    610                 615                 620                 


Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr Thr 
625                 630                 635                 640 


Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met Leu 
                645                 650                 655     


Leu Asn Thr Met Asp Lys 
            660         


<210>  210
<211>  700
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys 
    610                 615                 620                 


Gly Glu Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr 
625                 630                 635                 640 


Thr Ala Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met 
                645                 650                 655     


Leu Leu Asn Thr Met Asp Asn Ser Ala Gly Cys Thr Gly Arg Met Met 
            660                 665                 670         


Leu Val Ser Ala Trp Leu Leu Gly Arg Pro Gln Glu Thr Tyr Asn Gln 
        675                 680                 685             


Gly Arg Arg Arg Arg Gly Ser Arg Arg Val Thr Trp 
    690                 695                 700 


<210>  211
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn 
545                 550                 555                 560 


Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala 
                565                 570                 575     


Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu 
            580                 585                 590         


Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu 
        595                 600                 605             


Ala Ala Asn Gly Asp Gly Val Ile Ser Ala His Arg Asn Leu Cys Leu 
    610                 615                 620                 


Leu Gly Ser Ser Asp Ser His Ala Ser Val Ser Gly Ala Gly Ile Thr 
625                 630                 635                 640 


Asp Ala Arg His His Ala Trp Leu Ile Val Leu Leu Phe Leu Val Glu 
                645                 650                 655     


Met Gly Phe Tyr His Val Ser His Ser 
            660                 665 


<210>  212
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Leu 
545                 550                 555                 560 


Trp Val Gly Asn Ser Glu Val Ala Glu Leu Gly Gly Pro Gly Ser Gly 
                565                 570                 575     


Pro Leu Leu Arg Leu Gln Ser Gly Cys Pro Pro Gly Leu His His Pro 
            580                 585                 590         


Lys Ala Gly Leu Gly Pro Glu Asp Pro Leu Pro Gly Gln Leu Arg His 
        595                 600                 605             


Thr Thr Ala Gly Thr Gly Leu Ser Ser Leu Leu Gln Gly Pro Leu Cys 
    610                 615                 620                 


Arg Ala Ala 
625         


<210>  213
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Val His Met Arg Asn Leu 
385                 390                 395                 400 


His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser Ala Val 
                405                 410                 415     


Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His Lys Asn 
            420                 425                 430         


Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys Gln Glu 
        435                 440                 445             


Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys Pro Phe 
    450                 455                 460                 


Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu Leu Asn 
465                 470                 475                 480 


Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr Val Tyr 
                485                 490                 495     


Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn Leu His 
            500                 505                 510         


Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala Ala Ser 
        515                 520                 525             


Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu Lys Glu 
    530                 535                 540                 


Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu Ala Ala 
545                 550                 555                 560 


Asn Gly Asp Glu Ala Ala Ala Glu Glu Ala Ser Thr Thr Lys Gly Glu 
                565                 570                 575     


Gln Phe Pro Gly Glu Met Phe Pro Val Ala Cys Arg Glu Thr Thr Ala 
            580                 585                 590         


Arg Val Lys Glu Glu Val Asp Glu Gly Val Thr Cys Glu Met Leu Leu 
        595                 600                 605             


Asn Thr Met Asp Lys 
    610             


<210>  214
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr Gly Glu Arg 
        355                 360                 365             


Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys 
    370                 375                 380                 


Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met Lys Ile His 
                405                 410                 415     


Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln Cys Pro His 
            420                 425                 430         


Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val His Met Arg 
        435                 440                 445             


Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser 
    450                 455                 460                 


Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln Lys Thr His 
465                 470                 475                 480 


Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr Ala Cys Lys 
                485                 490                 495     


Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
            500                 505                 510         


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
        515                 520                 525             


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
    530                 535                 540                 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Thr 
545                 550                 555                 560 


Ser Lys Trp Ser Gly Leu Lys Pro Gln Thr Phe Ile Thr 
                565                 570             


<210>  215
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Glu Arg His Met Thr Ala His Ile Arg Thr His Thr Gly Glu Lys 
        355                 360                 365             


Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu 
    370                 375                 380                 


Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe Ile Pro Thr 
385                 390                 395                 400 


Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg Trp Ile Leu 
                405                 410                 415     


Trp Val Gly Asn Ser Glu Val Ala Glu Leu Gly Gly Pro Gly Ser Gly 
            420                 425                 430         


Pro Leu Leu Arg Leu Gln Ser Gly Cys Pro Pro Gly Leu His His Pro 
        435                 440                 445             


Lys Ala Gly Leu Gly Pro Glu Asp Pro Leu Pro Gly Gln Leu Arg His 
    450                 455                 460                 


Thr Thr Ala Gly Thr Gly Leu Ser Ser Leu Leu Gln Gly Pro Leu Cys 
465                 470                 475                 480 


Arg Ala Ala 
            


<210>  216
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ser Gly Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn 
1               5                   10                  15      


Ser Asn Val Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp 
            20                  25                  30          


Ala Glu Lys Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala 
        35                  40                  45              


Lys Gly Thr Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met 
    50                  55                  60                  


Ser Ser Phe Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His 
65                  70                  75                  80  


Leu Cys His Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg 
                85                  90                  95      


Asn His Val Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp 
            100                 105                 110         


Cys Asn Met Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg 
        115                 120                 125             


Tyr Lys His Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr 
    130                 135                 140                 


Ala Ser Val Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr 
145                 150                 155                 160 


Gly Glu Arg Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp 
                165                 170                 175     


Thr Tyr Lys Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro 
            180                 185                 190         


Tyr Glu Cys His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met 
        195                 200                 205             


Lys Ile His Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln 
    210                 215                 220                 


Cys Pro His Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val 
225                 230                 235                 240 


His Met Arg Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg 
                245                 250                 255     


Tyr Cys Ser Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln 
            260                 265                 270         


Lys Thr His Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr 
        275                 280                 285             


Ala Cys Lys Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln 
305                 310                 315                 320 


Lys Gln Leu Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe 
                325                 330                 335     


Ile Pro Thr Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg 
            340                 345                 350         


Trp Ile Asn Leu His Arg His Ser Glu Lys Cys Gly Ser Gly Glu Ala 
        355                 360                 365             


Lys Ser Ala Ala Ser Gly Lys Gly Arg Arg Thr Arg Lys Arg Lys Gln 
    370                 375                 380                 


Thr Ile Leu Lys Glu Ala Thr Lys Gly Gln Lys Glu Ala Ala Lys Gly 
385                 390                 395                 400 


Trp Lys Glu Ala Ala Asn Gly Asp Gly Val Ile Ser Ala His Arg Asn 
                405                 410                 415     


Leu Cys Leu Leu Gly Ser Ser Asp Ser His Ala Ser Val Ser Gly Ala 
            420                 425                 430         


Gly Ile Thr Asp Ala Arg His His Ala Trp Leu Ile Val Leu Leu Phe 
        435                 440                 445             


Leu Val Glu Met Gly Phe Tyr His Val Ser His Ser 
    450                 455                 460 


<210>  217
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ser Gly Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn 
1               5                   10                  15      


Ser Asn Val Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp 
            20                  25                  30          


Ala Glu Lys Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala 
        35                  40                  45              


Lys Gly Thr Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met 
    50                  55                  60                  


Ser Ser Phe Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His 
65                  70                  75                  80  


Leu Cys His Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg 
                85                  90                  95      


Asn His Val Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp 
            100                 105                 110         


Cys Asn Met Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg 
        115                 120                 125             


Tyr Lys His Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr 
    130                 135                 140                 


Ala Ser Val Glu Ala Ser Lys Leu Lys Arg His Val Arg Ser His Thr 
145                 150                 155                 160 


Gly Glu Arg Pro Phe Gln Cys Cys Gln Cys Ser Tyr Ala Ser Arg Asp 
                165                 170                 175     


Thr Tyr Lys Leu Lys Arg His Met Arg Thr His Ser Gly Glu Lys Pro 
            180                 185                 190         


Tyr Glu Cys His Ile Cys His Thr Arg Phe Thr Gln Ser Gly Thr Met 
        195                 200                 205             


Lys Ile His Ile Leu Gln Lys His Gly Glu Asn Val Pro Lys Tyr Gln 
    210                 215                 220                 


Cys Pro His Cys Ala Thr Ile Ile Ala Arg Lys Ser Asp Leu Arg Val 
225                 230                 235                 240 


His Met Arg Asn Leu His Ala Tyr Ser Ala Ala Glu Leu Lys Cys Arg 
                245                 250                 255     


Tyr Cys Ser Ala Val Phe His Glu Arg Tyr Ala Leu Ile Gln His Gln 
            260                 265                 270         


Lys Thr His Lys Asn Glu Lys Arg Phe Lys Cys Lys His Cys Ser Tyr 
        275                 280                 285             


Ala Cys Lys Gln Glu Arg His Met Thr Ala His Ile Arg Thr His Thr 
    290                 295                 300                 


Gly Glu Lys Pro Phe Thr Cys Leu Ser Cys Asn Lys Cys Phe Arg Gln 
305                 310                 315                 320 


Lys Gln Leu Leu Asn Ala His Phe Arg Lys Tyr His Asp Ala Asn Phe 
                325                 330                 335     


Ile Pro Thr Val Tyr Lys Cys Ser Lys Cys Gly Lys Gly Phe Ser Arg 
            340                 345                 350         


Trp Ile Leu Trp Val Gly Asn Ser Glu Val Ala Glu Leu Gly Gly Pro 
        355                 360                 365             


Gly Ser Gly Pro Leu Leu Arg Leu Gln Ser Gly Cys Pro Pro Gly Leu 
    370                 375                 380                 


His His Pro Lys Ala Gly Leu Gly Pro Glu Asp Pro Leu Pro Gly Gln 
385                 390                 395                 400 


Leu Arg His Thr Thr Ala Gly Thr Gly Leu Ser Ser Leu Leu Gln Gly 
                405                 410                 415     


Pro Leu Cys Arg Ala Ala 
            420         


<210>  218
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Ala Thr Glu Ile Ser Val Leu Ser Glu Gln Phe Thr Lys Ile 
1               5                   10                  15      


Lys Glu Leu Glu Leu Met Pro Glu Lys Gly Leu Lys Glu Glu Glu Lys 
            20                  25                  30          


Asp Gly Val Cys Arg Glu Lys Asp His Arg Ser Pro Ser Glu Leu Glu 
        35                  40                  45              


Ala Glu Arg Thr Ser Gly Ala Phe Gln Asp Ser Val Leu Glu Glu Glu 
    50                  55                  60                  


Val Glu Leu Val Leu Ala Pro Ser Glu Glu Ser Glu Lys Tyr Ile Leu 
65                  70                  75                  80  


Thr Leu Gln Thr Val His Phe Thr Ser Glu Ala Val Glu Leu Gln Asp 
                85                  90                  95      


Met Ser Leu Leu Ser Ile Gln Gln Gln Glu Gly Val Gln Val Val Val 
            100                 105                 110         


Gln Gln Pro Gly Pro Gly Leu Leu Trp Leu Glu Glu Gly Pro Arg Gln 
        115                 120                 125             


Ser Leu Gln Gln Cys Val Ala Ile Ser Ile Gln Gln Glu Leu Tyr Ser 
    130                 135                 140                 


Pro Gln Glu Met Glu Val Leu Gln Phe His Ala Leu Glu Glu Asn Val 
145                 150                 155                 160 


Met Val Ala Ser Glu Asp Ser Lys Leu Ala Val Ser Leu Ala Glu Thr 
                165                 170                 175     


Thr Gly Leu Ile Lys Leu Glu Glu Glu Gln Glu Lys Asn Gln Leu Leu 
            180                 185                 190         


Ala Glu Arg Thr Lys Glu Gln Leu Phe Phe Val Glu Thr Met Ser Gly 
        195                 200                 205             


Asp Glu Arg Ser Asp Glu Ile Val Leu Thr Val Ser Asn Ser Asn Val 
    210                 215                 220                 


Glu Glu Gln Glu Asp Gln Pro Thr Ala Gly Gln Ala Asp Ala Glu Lys 
225                 230                 235                 240 


Ala Lys Ser Thr Lys Asn Gln Arg Lys Thr Lys Gly Ala Lys Gly Thr 
                245                 250                 255     


Phe His Cys Asp Val Cys Met Phe Thr Ser Ser Arg Met Ser Ser Phe 
            260                 265                 270         


Asn Arg His Met Lys Thr His Thr Ser Glu Lys Pro His Leu Cys His 
        275                 280                 285             


Leu Cys Leu Lys Thr Phe Arg Thr Val Thr Leu Leu Arg Asn His Val 
    290                 295                 300                 


Asn Thr His Thr Gly Thr Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met 
305                 310                 315                 320 


Ala Phe Val Thr Ser Gly Glu Leu Val Arg His Arg Arg Tyr Lys His 
                325                 330                 335     


Thr His Glu Lys Pro Phe Lys Cys Ser Met Cys Lys Tyr Ala Ser Val 
            340                 345                 350         


Glu Val Lys Pro Phe Leu Asp Leu Lys Leu His Gly Ile Leu Val Glu 
        355                 360                 365             


Ala Ala Val Gln Val Thr Pro Ser Val Thr Asn Ser Arg Ile Cys Tyr 
    370                 375                 380                 


Lys Gln Ala Phe Tyr Tyr Ser Tyr Lys Ile Tyr Ala Gly Asn Asn Met 
385                 390                 395                 400 


His Ser Leu Leu 
                


<210>  219
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Phe Thr Ser Ser Arg Met Ser Ser Phe Asn Arg His Met Lys Thr 
1               5                   10                  15      


His Thr Ser Glu Lys Pro His Leu Cys His Leu Cys Leu Lys Thr Phe 
            20                  25                  30          


Arg Thr Val Thr Leu Leu Arg Asn His Val Asn Thr His Thr Gly Thr 
        35                  40                  45              


Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met Ala Phe Val Thr Ser Gly 
    50                  55                  60                  


Glu Leu Val Arg His Arg Arg Tyr Lys His Thr His Glu Lys Pro Phe 
65                  70                  75                  80  


Lys Cys Ser Met Cys Lys Tyr Ala Ser Val Glu Ala Ser Lys Leu Lys 
                85                  90                  95      


Arg His Val Arg Ser His Thr Gly Glu Arg Pro Phe Gln Cys Cys Gln 
            100                 105                 110         


Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys Leu Lys Arg His Met Arg 
        115                 120                 125             


Thr His Ser Gly Glu Lys Pro Tyr Glu Cys His Ile Cys His Thr Arg 
    130                 135                 140                 


Phe Thr Gln Ser Gly Thr Met Lys Ile His Ile Leu Gln Lys His Gly 
145                 150                 155                 160 


Glu Asn Val Pro Lys Tyr Gln Cys Pro His Cys Ala Thr Ile Ile Ala 
                165                 170                 175     


Arg Lys Ser Asp Leu Arg Val His Met Arg Asn Leu His Ala Tyr Ser 
            180                 185                 190         


Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser Ala Val Phe His Glu Arg 
        195                 200                 205             


Tyr Ala Leu Ile Gln His Gln Lys Thr His Lys Asn Glu Lys Arg Phe 
    210                 215                 220                 


Lys Cys Lys His Cys Ser Tyr Ala Cys Lys Gln Glu Arg His Met Thr 
225                 230                 235                 240 


Ala His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Thr Cys Leu Ser 
                245                 250                 255     


Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu Leu Asn Ala His Phe Arg 
            260                 265                 270         


Lys Tyr His Asp Ala Asn Phe Ile Pro Thr Val Tyr Lys Cys Ser Lys 
        275                 280                 285             


Cys Gly Lys Gly Phe Ser Arg Trp Ile Asn Leu His Arg His Ser Glu 
    290                 295                 300                 


Lys Cys Gly Ser Gly Glu Ala Lys Ser Ala Ala Ser Gly Lys Gly Arg 
305                 310                 315                 320 


Arg Thr Arg Lys Arg Lys Gln Thr Ile Leu Lys Glu Ala Thr Lys Gly 
                325                 330                 335     


Gln Lys Glu Ala Ala Lys Gly Trp Lys Glu Ala Ala Asn Gly Asp Gly 
            340                 345                 350         


Val Ile Ser Ala His Arg Asn Leu Cys Leu Leu Gly Ser Ser Asp Ser 
        355                 360                 365             


His Ala Ser Val Ser Gly Ala Gly Ile Thr Asp Ala Arg His His Ala 
    370                 375                 380                 


Trp Leu Ile Val Leu Leu Phe Leu Val Glu Met Gly Phe Tyr His Val 
385                 390                 395                 400 


Ser His Ser 
            


<210>  220
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Phe Thr Ser Ser Arg Met Ser Ser Phe Asn Arg His Met Lys Thr 
1               5                   10                  15      


His Thr Ser Glu Lys Pro His Leu Cys His Leu Cys Leu Lys Thr Phe 
            20                  25                  30          


Arg Thr Val Thr Leu Leu Arg Asn His Val Asn Thr His Thr Gly Thr 
        35                  40                  45              


Arg Pro Tyr Lys Cys Asn Asp Cys Asn Met Ala Phe Val Thr Ser Gly 
    50                  55                  60                  


Glu Leu Val Arg His Arg Arg Tyr Lys His Thr His Glu Lys Pro Phe 
65                  70                  75                  80  


Lys Cys Ser Met Cys Lys Tyr Ala Ser Val Glu Ala Ser Lys Leu Lys 
                85                  90                  95      


Arg His Val Arg Ser His Thr Gly Glu Arg Pro Phe Gln Cys Cys Gln 
            100                 105                 110         


Cys Ser Tyr Ala Ser Arg Asp Thr Tyr Lys Leu Lys Arg His Met Arg 
        115                 120                 125             


Thr His Ser Gly Glu Lys Pro Tyr Glu Cys His Ile Cys His Thr Arg 
    130                 135                 140                 


Phe Thr Gln Ser Gly Thr Met Lys Ile His Ile Leu Gln Lys His Gly 
145                 150                 155                 160 


Glu Asn Val Pro Lys Tyr Gln Cys Pro His Cys Ala Thr Ile Ile Ala 
                165                 170                 175     


Arg Lys Ser Asp Leu Arg Val His Met Arg Asn Leu His Ala Tyr Ser 
            180                 185                 190         


Ala Ala Glu Leu Lys Cys Arg Tyr Cys Ser Ala Val Phe His Glu Arg 
        195                 200                 205             


Tyr Ala Leu Ile Gln His Gln Lys Thr His Lys Asn Glu Lys Arg Phe 
    210                 215                 220                 


Lys Cys Lys His Cys Ser Tyr Ala Cys Lys Gln Glu Arg His Met Thr 
225                 230                 235                 240 


Ala His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Thr Cys Leu Ser 
                245                 250                 255     


Cys Asn Lys Cys Phe Arg Gln Lys Gln Leu Leu Asn Ala His Phe Arg 
            260                 265                 270         


Lys Tyr His Asp Ala Asn Phe Ile Pro Thr Val Tyr Lys Cys Ser Lys 
        275                 280                 285             


Cys Gly Lys Gly Phe Ser Arg Trp Val Leu Tyr 
    290                 295                 


<210>  221
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  222
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  223
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  224
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  225
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  226
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Gly Gln Lys 
    130                 135                 140                 


Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu 
145                 150                 155                 160 


Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly 
                165                 170                 175     


Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala 
            180                 185                 190         


Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys 
        195                 200                 205             


Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu 
    210                 215                 220                 


Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr 
225                 230                 235                 240 


Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val 
                245                 250                 255     


Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu 
            260                 265                 270         


Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys 
        275                 280                 285             


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    290                 295                 300                 


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
305                 310                 315                 320 


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                325                 330                 335     


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            340                 345                 350         


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        355                 360                 365             


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    370                 375                 380                 


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                405                 410                 415     


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            420                 425                 430         


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        435                 440                 445             


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    450                 455                 460                 


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
465                 470                 475                 480 


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                485                 490                 495     


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            500                 505                 510         


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        515                 520                 525             


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    530                 535                 540                 


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
545                 550                 555                 560 


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                565                 570                 575     


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            580                 585                 590         


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        595                 600                 605             


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
    610                 615                 620                 


Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu 
625                 630                 635                 640 


Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln 
                645                 650                 655     


Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val 
            660                 665                 670         


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro 
        675                 680                 685             


Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu 
    690                 695                 700                 


Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
705                 710                 715                 720 


Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys 
                725                 730                 735     


Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys 
            740                 745                 750         


Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr 
        755                 760                 765             


Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu 
    770                 775                 780                 


Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
785                 790                 795                 800 


Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu 
                805                 810                 815     


Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro 
            820                 825                 830         


Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His 
        835                 840                 845             


Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr 
    850                 855                 860                 


Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser 
865                 870                 875                 880 


Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile 
                885                 890                 895     


Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser 
            900                 905                 910         


Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg 
        915                 920                 925             


Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu 
    930                 935                 940                 


Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu 
945                 950                 955                 960 


Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
                965                 970                 975     


Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser 
            980                 985                 990         


Leu Ser Ala Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
        995                 1000                 1005             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1010                 1015                 1020             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1025                 1030                 1035             


Asp Thr  Phe Leu Pro Val Pro  Gly Glu Trp Leu Val  Trp Lys Gln 
    1040                 1045                 1050             


Ser Cys  Ser Ser Thr Ser Ser  Thr His Ser Ala Ala  Ala Ser Leu 
    1055                 1060                 1065             


Gln Cys  Pro Ser Gln Val Leu  Pro Pro Ala Ser Pro  Glu Gly Glu 
    1070                 1075                 1080             


Thr Val  Ala Asp Leu Gln Thr  Gln 
    1085                 1090     


<210>  227
<211>  1136
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Gly Glu Trp Leu Val  Trp Lys Gln 
    1085                 1090                 1095             


Ser Cys  Ser Ser Thr Ser Ser  Thr His Ser Ala Ala  Ala Ser Leu 
    1100                 1105                 1110             


Gln Cys  Pro Ser Gln Val Leu  Pro Pro Ala Ser Pro  Glu Gly Glu 
    1115                 1120                 1125             


Thr Val  Ala Asp Leu Gln Thr  Gln 
    1130                 1135     


<210>  228
<211>  1165
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Gly Gln Lys 
    130                 135                 140                 


Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu 
145                 150                 155                 160 


Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly 
                165                 170                 175     


Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala 
            180                 185                 190         


Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys 
        195                 200                 205             


Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu 
    210                 215                 220                 


Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr 
225                 230                 235                 240 


Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val 
                245                 250                 255     


Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu 
            260                 265                 270         


Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys 
        275                 280                 285             


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    290                 295                 300                 


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
305                 310                 315                 320 


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                325                 330                 335     


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            340                 345                 350         


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        355                 360                 365             


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    370                 375                 380                 


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                405                 410                 415     


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            420                 425                 430         


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        435                 440                 445             


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    450                 455                 460                 


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
465                 470                 475                 480 


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                485                 490                 495     


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            500                 505                 510         


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        515                 520                 525             


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    530                 535                 540                 


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
545                 550                 555                 560 


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                565                 570                 575     


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            580                 585                 590         


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        595                 600                 605             


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
    610                 615                 620                 


Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu 
625                 630                 635                 640 


Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln 
                645                 650                 655     


Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val 
            660                 665                 670         


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro 
        675                 680                 685             


Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu 
    690                 695                 700                 


Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
705                 710                 715                 720 


Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys 
                725                 730                 735     


Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys 
            740                 745                 750         


Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr 
        755                 760                 765             


Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu 
    770                 775                 780                 


Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
785                 790                 795                 800 


Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu 
                805                 810                 815     


Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro 
            820                 825                 830         


Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His 
        835                 840                 845             


Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr 
    850                 855                 860                 


Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser 
865                 870                 875                 880 


Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile 
                885                 890                 895     


Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser 
            900                 905                 910         


Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg 
        915                 920                 925             


Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu 
    930                 935                 940                 


Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu 
945                 950                 955                 960 


Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
                965                 970                 975     


Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser 
            980                 985                 990         


Leu Ser Ala Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
        995                 1000                 1005             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1010                 1015                 1020             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1025                 1030                 1035             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1040                 1045                 1050             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1055                 1060                 1065             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1070                 1075                 1080             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1085                 1090                 1095             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1100                 1105                 1110             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1115                 1120                 1125             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1130                 1135                 1140             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1145                 1150                 1155             


Ser Ser  Glu Phe Ile Gly Ala  
    1160                 1165 


<210>  229
<211>  1157
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr 
1               5                   10                  15      


Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val 
            20                  25                  30          


Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu 
        35                  40                  45              


Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr 
    50                  55                  60                  


Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys 
65                  70                  75                  80  


Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg 
                85                  90                  95      


Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg 
            100                 105                 110         


Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln 
        115                 120                 125             


Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly 
    130                 135                 140                 


Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile 
145                 150                 155                 160 


Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser 
                165                 170                 175     


Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu 
            180                 185                 190         


Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys 
        195                 200                 205             


Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met 
    210                 215                 220                 


Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys 
225                 230                 235                 240 


Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
                245                 250                 255     


Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
            260                 265                 270         


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly 
        275                 280                 285             


Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
    290                 295                 300                 


His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro 
305                 310                 315                 320 


Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro 
                325                 330                 335     


Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu 
            340                 345                 350         


Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu 
        355                 360                 365             


Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser 
    370                 375                 380                 


Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu 
385                 390                 395                 400 


Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu 
                405                 410                 415     


Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly 
            420                 425                 430         


Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala 
        435                 440                 445             


Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly 
    450                 455                 460                 


Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg 
465                 470                 475                 480 


Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe 
                485                 490                 495     


Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln 
            500                 505                 510         


Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln 
        515                 520                 525             


Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala 
    530                 535                 540                 


Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala 
545                 550                 555                 560 


Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr 
                565                 570                 575     


Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
            580                 585                 590         


Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
        595                 600                 605             


Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Lys Arg 
    610                 615                 620                 


Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu Val Glu Pro Leu Thr 
625                 630                 635                 640 


Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu 
                645                 650                 655     


Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr 
            660                 665                 670         


Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro 
        675                 680                 685             


Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys 
    690                 695                 700                 


Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His 
705                 710                 715                 720 


Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile 
                725                 730                 735     


Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His 
            740                 745                 750         


Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile 
        755                 760                 765             


Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp 
    770                 775                 780                 


Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile 
785                 790                 795                 800 


Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr 
                805                 810                 815     


His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser 
            820                 825                 830         


Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly 
        835                 840                 845             


Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly 
    850                 855                 860                 


Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu 
865                 870                 875                 880 


Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys 
                885                 890                 895     


Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile 
            900                 905                 910         


Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile 
        915                 920                 925             


Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe 
    930                 935                 940                 


Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala 
945                 950                 955                 960 


Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr 
                965                 970                 975     


Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser 
            980                 985                 990         


Thr Val Ala Cys Ile Asp Arg Asn  Gly Leu Gln Ser Cys  Pro Ile Lys 
        995                 1000                 1005             


Glu Asp  Ser Phe Leu Gln Arg  Tyr Ser Ser Asp Pro  Thr Gly Ala 
    1010                 1015                 1020             


Leu Thr  Glu Asp Ser Ile Asp  Asp Thr Phe Leu Pro  Val Pro Glu 
    1025                 1030                 1035             


Tyr Ile  Asn Gln Ser Val Pro  Lys Arg Pro Ala Gly  Ser Val Gln 
    1040                 1045                 1050             


Asn Pro  Val Tyr His Asn Gln  Pro Leu Asn Pro Ala  Pro Ser Arg 
    1055                 1060                 1065             


Asp Pro  His Tyr Gln Asp Pro  His Ser Thr Ala Val  Gly Asn Pro 
    1070                 1075                 1080             


Glu Tyr  Leu Asn Thr Val Gln  Pro Thr Cys Val Asn  Ser Thr Phe 
    1085                 1090                 1095             


Asp Ser  Pro Ala His Trp Ala  Gln Lys Gly Ser His  Gln Ile Ser 
    1100                 1105                 1110             


Leu Asp  Asn Pro Asp Tyr Gln  Gln Asp Phe Phe Pro  Lys Glu Ala 
    1115                 1120                 1125             


Lys Pro  Asn Gly Ile Phe Lys  Gly Ser Thr Ala Glu  Asn Ala Glu 
    1130                 1135                 1140             


Tyr Leu  Arg Val Ala Pro Gln  Ser Ser Glu Phe Ile  Gly Ala 
    1145                 1150                 1155         


<210>  230
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr 
            20                  25                  30          


Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser 
        35                  40                  45              


Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly 
    50                  55                  60                  


Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
65                  70                  75                  80  


Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
                85                  90                  95      


Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
            100                 105                 110         


Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
        115                 120                 125             


Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
    130                 135                 140                 


Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
145                 150                 155                 160 


Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
                165                 170                 175     


Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
            180                 185                 190         


Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
        195                 200                 205             


Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
    210                 215                 220                 


Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
225                 230                 235                 240 


Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
                245                 250                 255     


Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
            260                 265                 270         


Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
        275                 280                 285             


Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
    290                 295                 300                 


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
305                 310                 315                 320 


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
                325                 330                 335     


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
            340                 345                 350         


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
        355                 360                 365             


Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
    370                 375                 380                 


Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
385                 390                 395                 400 


Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
                405                 410                 415     


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            420                 425                 430         


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        435                 440                 445             


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    450                 455                 460                 


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
465                 470                 475                 480 


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                485                 490                 495     


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            500                 505                 510         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe 
        515                 520                 525             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    530                 535                 540                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
545                 550                 555                 560 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                565                 570                 575     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            580                 585                 590         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        595                 600                 605             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    610                 615                 620                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
625                 630                 635                 640 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                645                 650                 655     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            660                 665                 670         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        675                 680                 685             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    690                 695                 700                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
705                 710                 715                 720 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                725                 730                 735     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            740                 745                 750         


Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu 
        755                 760                 765             


Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp 
    770                 775                 780                 


Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln 
785                 790                 795                 800 


Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp 
                805                 810                 815     


Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys 
            820                 825                 830         


Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu 
        835                 840                 845             


Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr 
    850                 855                 860                 


Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val 
865                 870                 875                 880 


Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His 
                885                 890                 895     


Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys 
            900                 905                 910         


Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala 
        915                 920                 925             


Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    930                 935                 940             


<210>  231
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  232
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  233
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Gln Asn Ile Met Asn Asp Met Pro Ile Tyr Met Tyr Ser Val Cys 
1               5                   10                  15      


Asn Val Met Ser Gly Asp Gln Asp Asn Trp Leu Arg Thr Asn Trp Val 
            20                  25                  30          


Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile Glu Leu Lys Phe Thr Val 
        35                  40                  45              


Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala Ser Ser Cys Lys Glu Thr 
    50                  55                  60                  


Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu Asp Tyr Gly Thr Asn Phe 
65                  70                  75                  80  


Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr Ile Ala Pro Asp Glu Ile 
                85                  90                  95      


Thr Val Ser Ser Asp Phe Glu Ala Arg His Val Lys Leu Asn Val Glu 
            100                 105                 110         


Glu Arg Ser Val Gly Pro Leu Thr Arg Lys Gly Phe Tyr Leu Ala Phe 
        115                 120                 125             


Gln Asp Ile Gly Ala Cys Val Ala Leu Leu Ser Val Arg Val Tyr Tyr 
    130                 135                 140                 


Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu Ala His Phe Pro Glu Thr 
145                 150                 155                 160 


Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala Thr Val Ala Gly Thr Cys 
                165                 170                 175     


Val Asp His Ala Val Val Pro Pro Gly Gly Glu Glu Pro Arg Met His 
            180                 185                 190         


Cys Ala Val Asp Gly Glu Trp Leu Val Pro Ile Gly Gln Cys Leu Cys 
        195                 200                 205             


Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala Cys Gln Ala Cys Ser Pro 
    210                 215                 220                 


Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser Pro Cys Leu Glu Cys Pro 
225                 230                 235                 240 


Glu His Thr Leu Pro Ser Pro Glu Gly Ala Thr Ser Cys Glu Cys Glu 
                245                 250                 255     


Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro Ala Ser Met Pro Cys Thr 
            260                 265                 270         


Arg Pro Pro Ser Ala Pro His Tyr Leu Thr Ala Val Gly Met Gly Ala 
        275                 280                 285             


Lys Val Glu Leu Arg Trp Thr Pro Pro Gln Asp Ser Gly Gly Arg Glu 
    290                 295                 300                 


Asp Ile Val Tyr Ser Val Thr Cys Glu Gln Cys Trp Pro Glu Ser Gly 
305                 310                 315                 320 


Glu Cys Gly Pro Cys Glu Ala Ser Val Arg Tyr Ser Glu Pro Pro His 
                325                 330                 335     


Gly Leu Thr Arg Thr Ser Val Thr Val Ser Asp Leu Glu Pro His Met 
            340                 345                 350         


Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn Gly Val Ser Gly Leu Val 
        355                 360                 365             


Thr Ser Arg Ser Phe Arg Thr Ala Ser Val Ser Ile Asn Gln Thr Glu 
    370                 375                 380                 


Pro Pro Lys Val Arg Leu Glu Gly Arg Ser Thr Thr Ser Leu Ser Val 
385                 390                 395                 400 


Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser Arg Val Trp Lys Tyr Glu 
                405                 410                 415     


Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn Ser Tyr Asn Val Arg Arg 
            420                 425                 430         


Thr Glu Gly Phe Ser Val Thr Leu Asp Asp Leu Ala Pro Asp Thr Thr 
        435                 440                 445             


Tyr Leu Val Gln Val Gln Ala Leu Thr Gln Glu Gly Gln Gly Ala Gly 
    450                 455                 460                 


Ser Lys Val His Glu Phe Gln Thr Leu Ser Pro Glu Gly Ser Gly Asn 
465                 470                 475                 480 


Leu Ala Val Ile Gly Gly Val Ala Val Gly Val Val Leu Leu Leu Val 
                485                 490                 495     


Leu Ala Gly Val Gly Phe Phe Ile His Arg Arg Arg Lys Asn Gln Arg 
            500                 505                 510         


Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe Ser Lys Ser Glu Gln Leu 
        515                 520                 525             


Lys Pro Leu Lys Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Asn 
    530                 535                 540                 


Gln Ala Val Leu Lys Phe Thr Thr Glu Ile His Pro Ser Cys Val Thr 
545                 550                 555                 560 


Arg Gln Lys Val Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly 
                565                 570                 575     


Met Leu Lys Thr Ser Ser Gly Lys Lys Glu Val Pro Val Ala Ile Lys 
            580                 585                 590         


Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln Arg Val Asp Phe Leu Gly 
        595                 600                 605             


Glu Ala Gly Ile Met Gly Gln Phe Ser His His Asn Ile Ile Arg Leu 
    610                 615                 620                 


Glu Gly Val Ile Ser Lys Tyr Lys Pro Met Met Ile Ile Thr Glu Tyr 
625                 630                 635                 640 


Met Glu Asn Gly Ala Leu Asp Lys Phe Leu Arg Glu Lys Asp Gly Glu 
                645                 650                 655     


Phe Ser Val Leu Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly 
            660                 665                 670         


Met Lys Tyr Leu Ala Asn Met Asn Tyr Val His Arg Asp Leu Ala Ala 
        675                 680                 685             


Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe 
    690                 695                 700                 


Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Thr Tyr Thr Thr 
705                 710                 715                 720 


Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ser 
                725                 730                 735     


Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Phe Gly Ile Val 
            740                 745                 750         


Met Trp Glu Val Met Thr Tyr Gly Glu Arg Pro Tyr Trp Glu Leu Ser 
        755                 760                 765             


Asn His Glu Val Met Lys Ala Ile Asn Asp Gly Phe Arg Leu Pro Thr 
    770                 775                 780                 


Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln Leu Met Met Gln Cys Trp 
785                 790                 795                 800 


Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe Ala Asp Ile Val Ser Ile 
                805                 810                 815     


Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser Leu Lys Thr Leu Ala Asp 
            820                 825                 830         


Phe Asp Pro Arg Val Ser Ile Arg Leu Pro Ser Thr Ser Gly Ser Glu 
        835                 840                 845             


Gly Val Pro Phe Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Lys Met 
    850                 855                 860                 


Gln Gln Tyr Thr Glu His Phe Met Ala Ala Gly Tyr Thr Ala Ile Glu 
865                 870                 875                 880 


Lys Val Val Gln Met Thr Asn Asp Asp Ile Lys Arg Ile Gly Val Arg 
                885                 890                 895     


Leu Pro Gly His Gln Lys Arg Ile Ala Tyr Ser Leu Leu Gly Leu Lys 
            900                 905                 910         


Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
        915                 920         


<210>  234
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  235
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  236
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 
1               5                   10                  15      


Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 
            20                  25                  30          


His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 
        35                  40                  45              


Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 
    50                  55                  60                  


Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 
65                  70                  75                  80  


Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
                85                  90                  95      


Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 
            100                 105                 110         


Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 
        115                 120                 125             


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 
    130                 135                 140                 


Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 
145                 150                 155                 160 


Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 
                165                 170                 175     


Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 
            180                 185                 190         


Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 
        195                 200                 205             


Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 
    210                 215                 220                 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
225                 230                 235                 240 


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
                245                 250                 255     


Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 
            260                 265                 270         


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 
        275                 280                 285             


Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 
    290                 295                 300                 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
305                 310                 315                 320 


Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
                325                 330                 335     


Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 
            340                 345                 350         


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
        355                 360                 365             


Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 
    370                 375                 380                 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
385                 390                 395                 400 


Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 
                405                 410                 415     


Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
            420                 425                 430         


Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
        435                 440                 445             


Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 
    450                 455                 460                 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
465                 470                 475                 480 


Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 
                485                 490                 495     


His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
            500                 505                 510         


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
        515                 520                 525             


Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 
    530                 535                 540                 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 
545                 550                 555                 560 


Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 
                565                 570                 575     


Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
            580                 585                 590         


Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 
        595                 600                 605             


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 
    610                 615                 620                 


Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 
625                 630                 635                 640 


Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 
                645                 650                 655     


Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665                 670         


Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 
        675                 680                 685             


Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 
    690                 695                 700                 


Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
705                 710                 715                 720 


Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 
                725                 730                 735     


Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 
            740                 745                 750         


Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 
        755                 760                 765             


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 
    770                 775                 780                 


Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 
785                 790                 795                 800 


Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 
                805                 810                 815     


Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 
            820                 825                 830         


Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 
        835                 840                 845             


Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 
    850                 855                 860                 


Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
865                 870                 875                 880 


Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
                885                 890                 895     


Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 
            900                 905                 910         


Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 
        915                 920                 925             


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
    930                 935                 940                 


Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 
945                 950                 955                 960 


Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 
                965                 970                 975     


Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 
            980                 985                 990         


Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
        995                 1000                 1005             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1010                 1015                 1020             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1025                 1030                 1035             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1040                 1045                 1050             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1055                 1060                 1065             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1070                 1075                 1080             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1085                 1090                 1095             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1100                 1105                 1110             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1115                 1120                 1125             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1130                 1135                 1140             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1145                 1150                 1155             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1160                 1165                 1170             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1175                 1180                 1185             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1190                 1195                 1200             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1205                 1210                 1215             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Asp Val Pro Val  
    1235                 1240 


<210>  237
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Asn Met  
    1055 


<210>  238
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 
        595                 600             


<210>  239
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210>  240
<211>  1292
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Asn Gln Phe Val Tyr  Arg Asp Gly 
    1040                 1045                 1050             


Gly Phe  Ala Ala Glu Gln Gly  Val Ser Val Pro Tyr  Arg Ala Pro 
    1055                 1060                 1065             


Thr Ser  Thr Ile Pro Glu Ala  Pro Val Ala Gln Gly  Ala Thr Ala 
    1070                 1075                 1080             


Glu Ile  Phe Asp Asp Ser Cys  Cys Asn Gly Thr Leu  Arg Lys Pro 
    1085                 1090                 1095             


Val Ala  Pro His Val Gln Glu  Asp Ser Ser Thr Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Ala Asp  Pro Thr Val Phe Ala  Pro Glu Arg Ser Pro  Arg Gly Glu 
    1115                 1120                 1125             


Leu Asp  Glu Glu Gly Tyr Met  Thr Pro Met Arg Asp  Lys Pro Lys 
    1130                 1135                 1140             


Gln Glu  Tyr Leu Asn Pro Val  Glu Glu Asn Pro Phe  Val Ser Arg 
    1145                 1150                 1155             


Arg Lys  Asn Gly Asp Leu Gln  Ala Leu Asp Asn Pro  Glu Tyr His 
    1160                 1165                 1170             


Asn Ala  Ser Asn Gly Pro Pro  Lys Ala Glu Asp Glu  Tyr Val Asn 
    1175                 1180                 1185             


Glu Pro  Leu Tyr Leu Asn Thr  Phe Ala Asn Thr Leu  Gly Lys Ala 
    1190                 1195                 1200             


Glu Tyr  Leu Lys Asn Asn Ile  Leu Ser Met Pro Glu  Lys Ala Lys 
    1205                 1210                 1215             


Lys Ala  Phe Asp Asn Pro Asp  Tyr Trp Asn His Ser  Leu Pro Pro 
    1220                 1225                 1230             


Arg Ser  Thr Leu Gln His Pro  Asp Tyr Leu Gln Glu  Tyr Ser Thr 
    1235                 1240                 1245             


Lys Tyr  Phe Tyr Lys Gln Asn  Gly Arg Ile Arg Pro  Ile Val Ala 
    1250                 1255                 1260             


Glu Asn  Pro Glu Tyr Leu Ser  Glu Phe Ser Leu Lys  Pro Gly Thr 
    1265                 1270                 1275             


Val Leu  Pro Pro Pro Pro Tyr  Arg His Arg Asn Thr  Val Val 
    1280                 1285                 1290         


<210>  241
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  242
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro 
                245                 250                 255     


Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr 
    290                 295                 300                 


Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  243
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  244
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  245
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Thr Ala Gly Ser Ser Tyr Pro Leu Phe Leu Ala Ala Tyr Ala Cys 
1               5                   10                  15      


Thr Gly Cys Leu Ala Glu Arg Leu Gly Trp Phe Ile Lys Ser Ser Asn 
            20                  25                  30          


Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp 
        35                  40                  45              


Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln 
    50                  55                  60                  


Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln 
65                  70                  75                  80  


Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala 
                85                  90                  95      


His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr 
            100                 105                 110         


Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu 
        115                 120                 125             


Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro 
    130                 135                 140                 


Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val 
145                 150                 155                 160 


Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp 
                165                 170                 175     


Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys 
            180                 185                 190         


Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys 
        195                 200                 205             


Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 
    210                 215                 220                 


Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg 
225                 230                 235                 240 


Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly 
                245                 250                 255     


Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val 
            260                 265                 270         


Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln 
        275                 280                 285             


Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp 
    290                 295                 300                 


Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly 
305                 310                 315                 320 


Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu 
                325                 330                 335     


Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu 
            340                 345                 350         


Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe 
        355                 360                 365             


Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val 
    370                 375                 380                 


Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr 
385                 390                 395                 400 


Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser 
                405                 410                 415     


Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val 
            420                 425                 430         


Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg 
        435                 440                 445             


Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys 
    450                 455                 460                 


Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu 
465                 470                 475                 480 


Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg 
                485                 490                 495     


Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg 
            500                 505                 510         


Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr 
        515                 520                 525             


Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr 
    530                 535                 540                 


Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr 
545                 550                 555                 560 


Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile 
                565                 570                 575     


Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr 
            580                 585                 590         


Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys 
        595                 600                 605             


Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe 
    610                 615                 620                 


Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys 
625                 630                 635                 640 


Ser Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu 
                645                 650                 655     


Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr 
            660                 665                 670         


Arg His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
        675                 680                 685             


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
    690                 695                 700                 


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
705                 710                 715                 720 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
                725                 730                 735 


<210>  246
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Thr Ala Gly Ser Ser Tyr Pro Leu Phe Leu Ala Ala Tyr Ala Cys 
1               5                   10                  15      


Thr Gly Cys Leu Ala Glu Arg Leu Gly Trp Phe Ile Lys Ser Ser Asn 
            20                  25                  30          


Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp 
        35                  40                  45              


Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln 
    50                  55                  60                  


Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln 
65                  70                  75                  80  


Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala 
                85                  90                  95      


His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr 
            100                 105                 110         


Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu 
        115                 120                 125             


Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro 
    130                 135                 140                 


Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val 
145                 150                 155                 160 


Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp 
                165                 170                 175     


Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys 
            180                 185                 190         


Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys 
        195                 200                 205             


Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 
    210                 215                 220                 


Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg 
225                 230                 235                 240 


Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly 
                245                 250                 255     


Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val 
            260                 265                 270         


Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln 
        275                 280                 285             


Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp 
    290                 295                 300                 


Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly 
305                 310                 315                 320 


Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu 
                325                 330                 335     


Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu 
            340                 345                 350         


Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe 
        355                 360                 365             


Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val 
    370                 375                 380                 


Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr 
385                 390                 395                 400 


Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser 
                405                 410                 415     


Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val 
            420                 425                 430         


Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg 
        435                 440                 445             


Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys 
    450                 455                 460                 


Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu 
465                 470                 475                 480 


Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg 
                485                 490                 495     


Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg 
            500                 505                 510         


Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr 
        515                 520                 525             


Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr 
    530                 535                 540                 


Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr 
545                 550                 555                 560 


Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile 
                565                 570                 575     


Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr 
            580                 585                 590         


Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys 
        595                 600                 605             


Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe 
    610                 615                 620                 


Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys 
625                 630                 635                 640 


Ser Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly 
                645                 650                 655     


Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys 
            660                 665                 670         


Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val 
        675                 680                 685             


Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
    690                 695                 700                 


<210>  247
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys 
1               5                   10                  15      


Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln 
            20                  25                  30          


Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr 
        35                  40                  45              


Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val 
    50                  55                  60                  


Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro 
65                  70                  75                  80  


Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser Phe Gly Thr 
                85                  90                  95      


Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser 
            100                 105                 110         


Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu 
        115                 120                 125             


Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala 
    130                 135                 140                 


Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro 
145                 150                 155                 160 


Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu Leu Lys Ser Pro 
                165                 170                 175     


Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys 
            180                 185                 190         


Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly 
        195                 200                 205             


Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser 
    210                 215                 220                 


Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly 
225                 230                 235                 240 


Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys 
                245                 250                 255     


Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg 
            260                 265                 270         


Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp 
        275                 280                 285             


Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr 
    290                 295                 300                 


Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr Ser Val Ser 
305                 310                 315                 320 


Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser 
                325                 330                 335     


Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn Pro Ile Val 
            340                 345                 350         


Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg Ala Phe Ile 
        355                 360                 365             


Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His Val Ile Tyr 
    370                 375                 380                 


Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile 
385                 390                 395                 400 


Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala 
                405                 410                 415     


Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln 
            420                 425                 430         


Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
        435                 440         


<210>  248
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Lys Ala Phe Leu Asp Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe 
1               5                   10                  15      


Leu Tyr Asn Phe Thr Gln Ile Pro His Leu Ala Gly Thr Glu Gln Asn 
            20                  25                  30          


Phe Gln Leu Ala Lys Gln Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu 
        35                  40                  45              


Asp Ser Val Glu Leu Ala His Tyr Asp Val Leu Leu Ser Tyr Pro Asn 
    50                  55                  60                  


Lys Thr His Pro Asn Tyr Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu 
65                  70                  75                  80  


Ile Phe Asn Thr Ser Leu Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn 
                85                  90                  95      


Val Ser Asp Ile Val Pro Pro Phe Ser Ala Phe Ser Pro Gln Gly Met 
            100                 105                 110         


Pro Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe 
        115                 120                 125             


Phe Lys Leu Glu Arg Asp Met Lys Ile Asn Cys Ser Gly Lys Ile Val 
    130                 135                 140                 


Ile Ala Arg Tyr Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala 
145                 150                 155                 160 


Gln Leu Ala Gly Ala Lys Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp 
                165                 170                 175     


Tyr Phe Ala Pro Gly Val Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro 
            180                 185                 190         


Gly Gly Gly Val Gln Arg Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly 
        195                 200                 205             


Asp Pro Leu Thr Pro Gly Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg 
    210                 215                 220                 


Gly Ile Ala Glu Ala Val Gly Leu Pro Ser Ile Pro Val His Pro Ile 
225                 230                 235                 240 


Gly Tyr Tyr Asp Ala Gln Lys Leu Leu Glu Lys Met Gly Gly Ser Ala 
                245                 250                 255     


Pro Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys Val Pro Tyr Asn Val 
            260                 265                 270         


Gly Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His 
        275                 280                 285             


Ile His Ser Thr Asn Glu Val Thr Arg Ile Tyr Asn Val Ile Gly Thr 
    290                 295                 300                 


Leu Arg Gly Ala Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His 
305                 310                 315                 320 


Arg Asp Ser Trp Val Phe Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala 
                325                 330                 335     


Val Val His Glu Ile Val Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly 
            340                 345                 350         


Trp Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu 
        355                 360                 365             


Phe Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu 
    370                 375                 380                 


Leu Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu 
385                 390                 395                 400 


Gly Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu 
                405                 410                 415     


Val His Asn Leu Thr Lys Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu 
            420                 425                 430         


Gly Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu 
        435                 440                 445             


Phe Ser Gly Met Pro Arg Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe 
    450                 455                 460                 


Glu Val Phe Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr 
465                 470                 475                 480 


Thr Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His 
                485                 490                 495     


Ser Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys Phe Tyr Asp Pro Met 
            500                 505                 510         


Phe Lys Tyr His Leu Thr Val Ala Gln Val Arg Gly Gly Met Val Phe 
        515                 520                 525             


Glu Leu Ala Asn Ser Ile Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala 
    530                 535                 540                 


Val Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys 
545                 550                 555                 560 


His Pro Gln Glu Met Lys Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe 
                565                 570                 575     


Ser Ala Val Lys Asn Phe Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg 
            580                 585                 590         


Leu Gln Asp Phe Asp Lys Ser Lys His Val Ile Tyr Ala Pro Ser Ser 
        595                 600                 605             


His Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu 
    610                 615                 620                 


Phe Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala Trp Gly Glu Val 
625                 630                 635                 640 


Lys Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
                645                 650                 655     


Thr Leu Ser Glu Val Ala 
            660         


<210>  249
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln 
        35                  40                  45              


Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr 
    50                  55                  60                  


Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro 
65                  70                  75                  80  


Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro 
                85                  90                  95      


Cys Glu Gln Ile Ser Pro Glu Glu Glu Glu Arg Arg Arg Val Arg Arg 
            100                 105                 110         


Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg Lys Glu 
        115                 120                 125             


Leu Thr Asp Phe Leu Gln Ala Glu Thr Asp Lys Leu Glu Asp Glu Lys 
    130                 135                 140                 


Ser Gly Leu Gln Arg Glu Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg 
145                 150                 155                 160 


Leu Glu Leu Val Leu Glu Ala His Arg Pro Ile Cys Lys Ile Pro Glu 
                165                 170                 175     


Gly Ala Lys Glu Gly Asp Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro 
            180                 185                 190         


Pro Ala Pro Cys Arg Pro Val Pro Cys Ile Ser Leu Ser Pro Gly Pro 
        195                 200                 205             


Val Leu Glu Pro Glu Ala Leu His Thr Pro Thr Leu Met Thr Thr Pro 
    210                 215                 220                 


Ser Leu Thr Pro Phe Thr Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr 
225                 230                 235                 240 


Pro Glu Pro Cys Ala Ser Ala His Arg Lys Ser Ser Ser Ser Ser Gly 
                245                 250                 255     


Asp Pro Ser Ser Asp Pro Leu Gly Ser Pro Thr Leu Leu Ala Leu 
            260                 265                 270     


<210>  250
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln 
        35                  40                  45              


Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr 
    50                  55                  60                  


Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro 
65                  70                  75                  80  


Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro 
                85                  90                  95      


Cys Glu Gln Glu Thr Asp Lys Leu Glu Asp Glu Lys Ser Gly Leu Gln 
            100                 105                 110         


Arg Glu Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg Leu Glu Leu Val 
        115                 120                 125             


Leu Glu Ala His Arg Pro Ile Cys Lys Ile Pro Glu Gly Ala Lys Glu 
    130                 135                 140                 


Gly Asp Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro Pro Ala Pro Cys 
145                 150                 155                 160 


Arg Pro Val Pro Cys Ile Ser Leu Ser Pro Gly Pro Val Leu Glu Pro 
                165                 170                 175     


Glu Ala Leu His Thr Pro Thr Leu Met Thr Thr Pro Ser Leu Thr Pro 
            180                 185                 190         


Phe Thr Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr Pro Glu Pro Cys 
        195                 200                 205             


Ala Ser Ala His Arg Lys Ser Ser Ser Ser Ser Gly Asp Pro Ser Ser 
    210                 215                 220                 


Asp Pro Leu Gly Ser Pro Thr Leu Leu Ala Leu 
225                 230                 235 


<210>  251
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Lys Phe His Leu Val Pro Ser Ile Asn Thr Met Ser Gly Ser Gln 
        35                  40                  45              


Glu Leu Gln Trp Met Val Gln Pro His Phe Leu Gly Pro Ser Ser Tyr 
    50                  55                  60                  


Pro Arg Pro Leu Thr Tyr Pro Gln Tyr Ser Pro Pro Gln Pro Arg Pro 
65                  70                  75                  80  


Gly Val Ile Arg Ala Leu Gly Pro Pro Pro Gly Val Arg Arg Arg Pro 
                85                  90                  95      


Cys Glu Gln Pro Gly Gly Arg Gly Ala Pro Pro Ser Lys Ala Arg Ala 
            100                 105                 110         


Glu Gln Ala Gly Cys Gly Gln Val Gln Glu Pro Glu Glu Gly Thr Asp 
        115                 120                 125             


Arg Leu Pro Ala Gly Gly Asp 
    130                 135 


<210>  252
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Ile Ser Pro Glu Glu Glu Glu Arg Arg Arg Val Arg Arg Glu Arg 
        35                  40                  45              


Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg Lys Glu Leu Thr 
    50                  55                  60                  


Asp Phe Leu Gln Ala Glu Thr Asp Lys Leu Glu Asp Glu Lys Ser Gly 
65                  70                  75                  80  


Leu Gln Arg Glu Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg Leu Glu 
                85                  90                  95      


Leu Val Leu Glu Ala His Arg Pro Ile Cys Lys Ile Pro Glu Gly Ala 
            100                 105                 110         


Lys Glu Gly Asp Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro Pro Ala 
        115                 120                 125             


Pro Cys Arg Pro Val Pro Cys Ile Ser Leu Ser Pro Gly Pro Val Leu 
    130                 135                 140                 


Glu Pro Glu Ala Leu His Thr Pro Thr Leu Met Thr Thr Pro Ser Leu 
145                 150                 155                 160 


Thr Pro Phe Thr Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr Pro Glu 
                165                 170                 175     


Pro Cys Ala Ser Ala His Arg Lys Ser Ser Ser Ser Ser Gly Asp Pro 
            180                 185                 190         


Ser Ser Asp Pro Leu Gly Ser Pro Thr Leu Leu Ala Leu 
        195                 200                 205 


<210>  253
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Phe Arg Asp Phe Gly Glu Pro Gly Pro Ser Ser Gly Asn Gly Gly 
1               5                   10                  15      


Gly Tyr Gly Gly Pro Ala Gln Pro Pro Ala Ala Ala Gln Ala Ala Gln 
            20                  25                  30          


Gln Glu Thr Asp Lys Leu Glu Asp Glu Lys Ser Gly Leu Gln Arg Glu 
        35                  40                  45              


Ile Glu Glu Leu Gln Lys Gln Lys Glu Arg Leu Glu Leu Val Leu Glu 
    50                  55                  60                  


Ala His Arg Pro Ile Cys Lys Ile Pro Glu Gly Ala Lys Glu Gly Asp 
65                  70                  75                  80  


Thr Gly Ser Thr Ser Gly Thr Ser Ser Pro Pro Ala Pro Cys Arg Pro 
                85                  90                  95      


Val Pro Cys Ile Ser Leu Ser Pro Gly Pro Val Leu Glu Pro Glu Ala 
            100                 105                 110         


Leu His Thr Pro Thr Leu Met Thr Thr Pro Ser Leu Thr Pro Phe Thr 
        115                 120                 125             


Pro Ser Leu Val Phe Thr Tyr Pro Ser Thr Pro Glu Pro Cys Ala Ser 
    130                 135                 140                 


Ala His Arg Lys Ser Ser Ser Ser Ser Gly Asp Pro Ser Ser Asp Pro 
145                 150                 155                 160 


Leu Gly Ser Pro Thr Leu Leu Ala Leu 
                165                 


<210>  254
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Gly Gln Ser Gln Cys 
        115         


<210>  255
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu 
            100                 105                 110         


Lys Gln Ser Gln Cys 
        115         


<210>  256
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  257
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  258
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  258

Met His Ser Lys Thr Pro Cys Gly Cys Phe Lys Pro Trp Lys Met Ala 
1               5                   10                  15      


Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro Asn 
            20                  25                  30          


Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala Gly 
        35                  40                  45              


Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala Pro 
    50                  55                  60                  


Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly Ala 
65                  70                  75                  80  


Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala Thr 
            100                 105                 110         


Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro Leu 
        115                 120                 125             


Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met 
    130                 135                 140                 


Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala 
145                 150                 155                 160 


Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
                165                 170                 175     


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp 
            180                 185                 190         


Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser 
        195                 200                 205             


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys 
    210                 215                 220                 


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys 
225                 230                 235                 240 


Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu 
                245                 250                 255     


Thr Ser Ala Ser Tyr Thr Met Ile 
            260                 


<210>  259
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
145                 150                 155                 160 


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
                165                 170                 175     


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
            180                 185                 190         


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
        195                 200                 205             


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
    210                 215                 220                 


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
225                 230                 235                 240 


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
                245                 250                 255     


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
            260                 265                 270         


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
        275                 280                 285             


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
    290                 295                 300                 


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
305                 310                 315                 320 


Val Gln Thr 
            


<210>  260
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  261
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
145                 150                 155                 160 


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
                165                 170                 175     


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
            180                 185                 190         


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
        195                 200                 205             


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Cys Gly Ser 
    210                 215                 220                 


Cys Val Lys Leu Thr Ala Ser Arg Trp Pro Trp Met Val Ser Thr Cys 
225                 230                 235                 240 


Leu Asn Thr Thr Ile Ala 
                245     


<210>  262
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Val Pro Gly Ile Leu 
            580                 585                 590         


Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly 
        595                 600                 605             


Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg 
    610                 615                 620                 


Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser 
625                 630                 635                 640 


Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile 
                645                 650                 655     


Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
            660                 665             


<210>  263
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 
            20                  25                  30          


Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 
        35                  40                  45              


Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 
    50                  55                  60                  


Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 
65                  70                  75                  80  


Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 
                85                  90                  95      


Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 
            100                 105                 110         


Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 
        115                 120                 125             


Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 
    130                 135                 140                 


His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 
145                 150                 155                 160 


Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 
                165                 170                 175     


Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 
            180                 185                 190         


Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 
        195                 200                 205             


Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 
    210                 215                 220                 


Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 
225                 230                 235                 240 


Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 
                245                 250                 255     


Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 
            260                 265                 270         


Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 
        275                 280                 285             


Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 
    290                 295                 300                 


Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 
305                 310                 315                 320 


Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 
                325                 330                 335     


Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 
            340                 345                 350         


Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 
        355                 360                 365             


Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 
    370                 375                 380                 


Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 
385                 390                 395                 400 


Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 
                405                 410                 415     


Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 
            420                 425                 430         


Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 
        435                 440                 445             


Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 
    450                 455                 460                 


Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 
465                 470                 475                 480 


Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 
                485                 490                 495     


Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 
            500                 505                 510         


Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 
        515                 520                 525             


Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 
    530                 535                 540                 


Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 
545                 550                 555                 560 


Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
                565                 570                 575 


<210>  264
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  265
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val Glu Thr 
    370                 375                 380                 


Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser 
385                 390                 395                 400 


Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 
                405                 410                 415     


Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro Leu Asp 
            420                 425                 430         


Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val 
        435                 440                 445             


Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu 
    450                 455                 460                 


Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys 
465                 470                 475                 480 


Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln 
                485                 490                 495     


Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu 
            500                 505                 510         


His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser 
        515                 520                 525             


Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Met 
    530                 535                 540                 


Pro Val Pro Gly Ile Leu Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln 
545                 550                 555                 560 


Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu 
                565                 570                 575     


Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val 
            580                 585                 590         


Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile 
        595                 600                 605             


Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln 
    610                 615                 620                 


Gln Val 
625     


<210>  266
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val Glu Thr 
    370                 375                 380                 


Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser 
385                 390                 395                 400 


Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu 
                405                 410                 415     


Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro Leu Asp 
            420                 425                 430         


Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp Ile Val 
        435                 440                 445             


Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu 
    450                 455                 460                 


Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys 
465                 470                 475                 480 


Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln 
                485                 490                 495     


Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu 
            500                 505                 510         


His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser 
        515                 520                 525             


Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Met 
    530                 535                 540                 


Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly Ile 
545                 550                 555                 560 


Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg Arg 
                565                 570                 575     


Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser Ser 
            580                 585                 590         


Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly 
        595                 600                 605             


Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
    610                 615                 


<210>  267
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  268
<211>  1281
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Met Thr  Asn Ala Trp 
    1250                 1255                 1260             


Leu Leu  Gly Asp Ala Pro Arg  Thr Leu Thr Asn Thr  Arg Cys His 
    1265                 1270                 1275             


Pro Arg  Arg 
    1280     


<210>  269
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Lys Met Leu Thr Arg Leu Gln Val Leu Thr Leu Ala Leu Phe Ser 
1               5                   10                  15      


Lys Gly Phe Leu Leu Ser Leu Gly Asp His Asn Phe Leu Arg Arg Glu 
            20                  25                  30          


Ile Lys Ile Glu Gly Asp Leu Val Leu Gly Gly Leu Phe Pro Ile Asn 
        35                  40                  45              


Glu Lys Gly Thr Gly Thr Glu Glu Cys Gly Arg Ile Asn Glu Asp Arg 
    50                  55                  60                  


Gly Ile Gln Arg Leu Glu Ala Met Leu Phe Ala Ile Asp Glu Ile Asn 
65                  70                  75                  80  


Lys Asp Asp Tyr Leu Leu Pro Gly Val Lys Leu Gly Val His Ile Leu 
                85                  90                  95      


Asp Thr Cys Ser Arg Asp Thr Tyr Ala Leu Glu Gln Ser Leu Glu Phe 
            100                 105                 110         


Val Arg Ala Ser Leu Thr Lys Val Asp Glu Ala Glu Tyr Met Cys Pro 
        115                 120                 125             


Asp Gly Ser Tyr Ala Ile Gln Glu Asn Ile Pro Leu Leu Ile Ala Gly 
    130                 135                 140                 


Val Ile Gly Gly Ser Tyr Ser Ser Val Ser Ile Gln Val Ala Asn Leu 
145                 150                 155                 160 


Leu Arg Leu Phe Gln Ile Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala 
                165                 170                 175     


Lys Leu Ser Asp Lys Ser Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro 
            180                 185                 190         


Pro Asp Phe Tyr Gln Ala Lys Ala Met Ala Glu Ile Leu Arg Phe Phe 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu 
    210                 215                 220                 


Thr Gly Ile Glu Ala Phe Glu Gln Glu Ala Arg Leu Arg Asn Ile Cys 
225                 230                 235                 240 


Ile Ala Thr Ala Glu Lys Val Gly Arg Ser Asn Ile Arg Lys Ser Tyr 
                245                 250                 255     


Asp Ser Val Ile Arg Glu Leu Leu Gln Lys Pro Asn Ala Arg Val Val 
            260                 265                 270         


Val Leu Phe Met Arg Ser Asp Asp Ser Arg Glu Leu Ile Ala Ala Ala 
        275                 280                 285             


Ser Arg Ala Asn Ala Ser Phe Thr Trp Val Ala Ser Asp Gly Trp Gly 
    290                 295                 300                 


Ala Gln Glu Ser Ile Ile Lys Gly Ser Glu His Val Ala Tyr Gly Ala 
305                 310                 315                 320 


Ile Thr Leu Glu Leu Ala Ser Gln Pro Val Arg Gln Phe Asp Arg Tyr 
                325                 330                 335     


Phe Gln Ser Leu Asn Pro Tyr Asn Asn His Arg Asn Pro Trp Phe Arg 
            340                 345                 350         


Asp Phe Trp Glu Gln Lys Phe Gln Cys Ser Leu Gln Asn Lys Arg Asn 
        355                 360                 365             


His Arg Arg Val Cys Asp Lys His Leu Ala Ile Asp Ser Ser Asn Tyr 
    370                 375                 380                 


Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala Val Tyr Ala Met 
385                 390                 395                 400 


Ala His Ala Leu His Lys Met Gln Arg Thr Leu Cys Pro Asn Thr Thr 
                405                 410                 415     


Lys Leu Cys Asp Ala Met Lys Ile Leu Asp Gly Lys Lys Leu Tyr Lys 
            420                 425                 430         


Asp Tyr Leu Leu Lys Ile Asn Phe Thr Ala Pro Phe Asn Pro Asn Lys 
        435                 440                 445             


Asp Ala Asp Ser Ile Val Lys Phe Asp Thr Phe Gly Asp Gly Met Gly 
    450                 455                 460                 


Arg Tyr Asn Val Phe Asn Phe Gln Asn Val Gly Gly Lys Tyr Ser Tyr 
465                 470                 475                 480 


Leu Lys Val Gly His Trp Ala Glu Thr Leu Ser Leu Asp Val Asn Ser 
                485                 490                 495     


Ile His Trp Ser Arg Asn Ser Val Pro Thr Ser Gln Cys Ser Asp Pro 
            500                 505                 510         


Cys Ala Pro Asn Glu Met Lys Asn Met Gln Pro Gly Asp Val Cys Cys 
        515                 520                 525             


Trp Ile Cys Ile Pro Cys Glu Pro Tyr Glu Tyr Leu Ala Asp Glu Phe 
    530                 535                 540                 


Thr Cys Met Asp Cys Gly Ser Gly Gln Trp Pro Thr Ala Asp Leu Thr 
545                 550                 555                 560 


Gly Cys Tyr Asp Leu Pro Glu Asp Tyr Ile Arg Trp Glu Asp Ala Trp 
                565                 570                 575     


Ala Ile Gly Pro Val Thr Ile Ala Cys Leu Gly Phe Met Cys Thr Cys 
            580                 585                 590         


Met Val Val Thr Val Phe Ile Lys His Asn Asn Thr Pro Leu Val Lys 
        595                 600                 605             


Ala Ser Gly Arg Glu Leu Cys Tyr Ile Leu Leu Phe Gly Val Gly Leu 
    610                 615                 620                 


Ser Tyr Cys Met Thr Phe Phe Phe Ile Ala Lys Pro Ser Pro Val Ile 
625                 630                 635                 640 


Cys Ala Leu Arg Arg Leu Gly Leu Gly Ser Ser Phe Ala Ile Cys Tyr 
                645                 650                 655     


Ser Ala Leu Leu Thr Lys Thr Asn Cys Ile Ala Arg Ile Phe Asp Gly 
            660                 665                 670         


Val Lys Asn Gly Ala Gln Arg Pro Lys Phe Ile Ser Pro Ser Ser Gln 
        675                 680                 685             


Val Phe Ile Cys Leu Gly Leu Ile Leu Val Gln Ile Val Met Val Ser 
    690                 695                 700                 


Val Trp Leu Ile Leu Glu Ala Pro Gly Thr Arg Arg Tyr Thr Leu Ala 
705                 710                 715                 720 


Glu Lys Arg Glu Thr Val Ile Leu Lys Cys Asn Val Lys Asp Ser Ser 
                725                 730                 735     


Met Leu Ile Ser Leu Thr Tyr Asp Val Ile Leu Val Ile Leu Cys Thr 
            740                 745                 750         


Val Tyr Ala Phe Lys Thr Arg Lys Cys Pro Glu Asn Phe Asn Glu Ala 
        755                 760                 765             


Lys Phe Ile Gly Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
    770                 775                 780                 


Phe Leu Pro Ile Phe Tyr Val Thr Ser Ser Asp Tyr Arg Val Gln Thr 
785                 790                 795                 800 


Thr Thr Met Cys Ile Ser Val Ser Leu Ser Gly Phe Val Val Leu Gly 
                805                 810                 815     


Cys Leu Phe Ala Pro Lys Val His Ile Ile Leu Phe Gln Pro Gln Lys 
            820                 825                 830         


Asn Val Val Thr His Arg Leu His Leu Asn Arg Phe Ser Val Ser Gly 
        835                 840                 845             


Thr Gly Thr Thr Tyr Ser Gln Ser Ser Ala Ser Thr Tyr Val Pro Thr 
    850                 855                 860                 


Val Cys Asn Gly Arg Glu Val Leu Asp Ser Thr Thr Ser Ser Leu 
865                 870                 875                 


<210>  270
<211>  158
<212>  PRT
<213>  Human papillomavirus

<400>  270

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  271
<211>  98
<212>  PRT
<213>  Human papillomavirus

<400>  271

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  272
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  273
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Thr Cys Pro Trp Cys Trp Trp Gly Thr Ser Val Thr Trp Leu His 
1               5                   10                  15      


Ala Leu Trp Asn Leu Gly Arg Leu Arg Thr Ser Pro Glu Ala Thr Ala 
            20                  25                  30          


Ser Pro Thr Ser Arg Pro Arg Pro Arg Pro Gly Arg Ala Ala Ala Leu 
        35                  40                  45              


Ala Leu Ala Pro Ala Pro Gly Pro Ser Gly Thr Pro Arg Asp Pro Cys 
    50                  55                  60                  


Asp Pro Ala Ala Pro Arg Ala Gly Val Glu Asp Ala Phe Tyr Thr Leu 
65                  70                  75                  80  


Val Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp 
                85                  90                  95      


Glu Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            100                 105                 110 


<210>  274
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Thr Leu Trp Asp Pro Pro Gly Pro Met 
                165                 170 


<210>  275
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  276
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  277
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Glu Gln Ile 
            500                 505                 510         


His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly Phe Val Ile Val 
        515                 520                 525             


Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu 
    530                 535                 540                 


Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn 
545                 550                 555                 560 


Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His 
                565                 570                 575     


Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly 
            580                 585                 590         


Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile 
        595                 600                 605             


Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser 
    610                 615                 620                 


Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu 
625                 630                 635                 640 


Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys 
                645                 650                 655     


Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly 
            660                 665                 670         


Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser 
        675                 680                 685             


Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His 
    690                 695                 700                 


Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met 
705                 710                 715                 720 


Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg 
                725                 730                 735     


Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile 
            740                 745                 750         


Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe 
        755                 760                 765             


Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys 
    770                 775                 780                 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg 
785                 790                 795                 800 


Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp 
                805                 810                 815     


Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met 
            820                 825                 830         


Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val 
        835                 840                 845             


Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser 
    850                 855                 860                 


Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys 
865                 870                 875                 880 


Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr 
                885                 890                 895     


Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr 
            900                 905                 910         


Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr 
        915                 920                 925             


Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys 
    930                 935                 940                 


Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala 
945                 950                 955                 960 


Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970         


<210>  278
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  279
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  280
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Lys Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu 
65                  70                  75                  80  


Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met 
                85                  90                  95      


Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser 
            100                 105                 110         


Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu 
        115                 120                 125             


Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val 
    130                 135                 140                 


His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr 
145                 150                 155                 160 


Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys 
                165                 170                 175     


Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala 
            180                 185                 190         


Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys 
        195                 200                 205             


Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
    210                 215             


<210>  281
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  282
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Arg Tyr Tyr Asn Gly His Thr Lys Val Ala Val Lys Ser Leu 
    210                 215                 220                 


Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu Ala Asn Leu 
225                 230                 235                 240 


Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr Ala Val Val 
                245                 250                 255     


Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu Asn Gly Ser 
            260                 265                 270         


Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu Thr Ile Asn 
        275                 280                 285             


Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met Ala Phe Ile 
    290                 295                 300                 


Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu 
305                 310                 315                 320 


Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg 
                325                 330                 335     


Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro 
            340                 345                 350         


Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr Phe Thr Ile 
        355                 360                 365             


Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Ile Val Thr 
    370                 375                 380                 


His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu Val Ile Gln 
385                 390                 395                 400 


Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn Cys Pro Glu 
                405                 410                 415     


Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg Pro Glu Asp 
            420                 425                 430         


Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp Phe Phe Thr 
        435                 440                 445             


Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
    450                 455             


<210>  283
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly 
1               5                   10                  15      


Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val 
            20                  25                  30          


Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp 
        35                  40                  45              


Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu 
    50                  55                  60                  


Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn 
65                  70                  75                  80  


Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr 
                85                  90                  95      


Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn 
            100                 105                 110         


Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly 
        115                 120                 125             


Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr 
    130                 135                 140                 


Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp 
145                 150                 155                 160 


Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His 
                165                 170                 175     


Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly 
            180                 185                 190         


Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr 
        195                 200                 205             


Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys 
    210                 215                 220                 


Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp 
225                 230                 235                 240 


Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His 
                245                 250                 255     


Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn 
            260                 265                 270         


Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg 
        275                 280                 285             


Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu 
    290                 295                 300                 


Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met 
305                 310                 315                 320 


Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln 
                325                 330                 335     


Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile 
            340                 345                 350         


Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser 
        355                 360                 365             


Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu 
    370                 375                 380                 


His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr 
385                 390                 395                 400 


Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr 
                405                 410                 415     


Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His 
            420                 425                 430         


Tyr 
    


<210>  284
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  285
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  286
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Pro Arg Ala Pro Lys Arg Gln Arg Cys Met Pro Glu Glu Asp Leu 
1               5                   10                  15      


Gln Ser Gln Ser Glu Thr Gln Gly Leu Glu Gly Ala Gln Ala Pro Leu 
            20                  25                  30          


Ala Val Glu Glu Asp Ala Ser Ser Ser Thr Ser Thr Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Cys Tyr 
    50                  55                  60                  


Pro Leu Ile Pro Ser Thr Pro Glu Glu Val Ser Ala Asp Asp Glu Thr 
65                  70                  75                  80  


Pro Asn Pro Pro Gln Ser Ala Gln Ile Ala Cys Ser Ser Pro Ser Val 
                85                  90                  95      


Val Ala Ser Leu Pro Leu Asp Gln Ser Asp Glu Gly Ser Ser Ser Gln 
            100                 105                 110         


Lys Glu Glu Ser Pro Ser Thr Leu Gln Val Leu Pro Asp Ser Glu Ser 
        115                 120                 125             


Leu Pro Arg Ser Glu Ile Asp Glu Lys Val Thr Asp Leu Val Gln Phe 
    130                 135                 140                 


Leu Leu Phe Lys Tyr Gln Met Lys Glu Pro Ile Thr Lys Ala Glu Ile 
145                 150                 155                 160 


Leu Glu Ser Val Ile Arg Asn Tyr Glu Asp His Phe Pro Leu Leu Phe 
                165                 170                 175     


Ser Glu Ala Ser Glu Cys Met Leu Leu Val Phe Gly Ile Asp Val Lys 
            180                 185                 190         


Glu Val Asp Pro Thr Gly His Ser Phe Val Leu Val Thr Ser Leu Gly 
        195                 200                 205             


Leu Thr Tyr Asp Gly Met Leu Ser Asp Val Gln Ser Met Pro Lys Thr 
    210                 215                 220                 


Gly Ile Leu Ile Leu Ile Leu Ser Ile Ile Phe Ile Glu Gly Tyr Cys 
225                 230                 235                 240 


Thr Pro Glu Glu Val Ile Trp Glu Ala Leu Asn Met Met Gly Leu Tyr 
                245                 250                 255     


Asp Gly Met Glu His Leu Ile Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
            260                 265                 270         


Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu Tyr Arg Gln Val Pro Gly 
        275                 280                 285             


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala His Ala 
    290                 295                 300                 


Glu Ile Arg Lys Met Ser Leu Leu Lys Phe Leu Ala Lys Val Asn Gly 
305                 310                 315                 320 


Ser Asp Pro Arg Ser Phe Pro Leu Trp Tyr Glu Glu Ala Leu Lys Asp 
                325                 330                 335     


Glu Glu Glu Arg Ala Gln Asp Arg Ile Ala Thr Thr Asp Asp Thr Thr 
            340                 345                 350         


Ala Met Ala Ser Ala Ser Ser Ser Ala Thr Gly Ser Phe Ser Tyr Pro 
        355                 360                 365             


Glu 
    


<210>  287
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Gln Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Thr Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Arg Glu Val Pro Ala Ala Glu Ser Pro Ser Pro Pro His Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Thr Leu Pro Thr Thr Ile Asn Tyr Thr Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Asp Glu Gly Ser Ser Asn Glu Glu Gln Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Thr Ser Phe Gln Val Ala Leu Ser Arg Lys 
            100                 105                 110         


Met Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Phe Thr Lys Ala Glu Met Leu Gly Ser Val Ile Arg Asn Phe Gln 
    130                 135                 140                 


Asp Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Glu Tyr Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Val Val Glu Val Val Arg Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Val Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Ala Ser Asp Gly Arg Glu Asp Ser Val Phe Ala 
225                 230                 235                 240 


His Pro Arg Lys Leu Leu Thr Gln Asp Leu Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Leu Leu Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Ala Phe Arg Glu Gly Glu Glu 
305                 310                 


<210>  288
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Gln Thr Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Asp Ser Pro Ser Pro Pro His Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Phe Ser Thr Thr Ile Asn Tyr Thr Leu Trp 
65                  70                  75                  80  


Arg Gln Ser Asp Glu Gly Ser Ser Asn Gln Glu Glu Glu Gly Pro Arg 
                85                  90                  95      


Met Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Ile Ser Arg Lys 
            100                 105                 110         


Met Val Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Glu Ser Val Leu Arg Asn Cys Gln 
    130                 135                 140                 


Asp Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Glu Tyr Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Val Val Glu Val Val Pro Ile Ser His Leu Tyr 
                165                 170                 175     


Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Val Met Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Ile Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Met Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Val Phe Ala 
225                 230                 235                 240 


His Pro Arg Lys Leu Leu Met Gln Asp Leu Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Thr Leu Lys Ile Gly Gly Glu Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Arg Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  289
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  290
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  291
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Lys Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Asp Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Val Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Thr Gly Phe Leu Ile Ile Ile Leu Ala Ile 
        195                 200                 205             


Ile Ala Lys Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Phe Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln Tyr Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Ile Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro Arg Ile Ser Tyr Pro Leu Leu 
    290                 295                 300                 


His Glu Trp Ala Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  292
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Ser Leu Glu Gln Arg Ser Pro His Cys Lys Pro Asp Glu Asp Leu 
1               5                   10                  15      


Glu Ala Gln Gly Glu Asp Leu Gly Leu Met Gly Ala Gln Glu Pro Thr 
            20                  25                  30          


Gly Glu Glu Glu Glu Thr Thr Ser Ser Ser Asp Ser Lys Glu Glu Glu 
        35                  40                  45              


Val Ser Ala Ala Gly Ser Ser Ser Pro Pro Gln Ser Pro Gln Gly Gly 
    50                  55                  60                  


Ala Ser Ser Ser Ile Ser Val Tyr Tyr Thr Leu Trp Ser Gln Phe Asp 
65                  70                  75                  80  


Glu Gly Ser Ser Ser Gln Glu Glu Glu Glu Pro Ser Ser Ser Val Asp 
                85                  90                  95      


Pro Ala Gln Leu Glu Phe Met Phe Gln Glu Ala Leu Lys Leu Lys Val 
            100                 105                 110         


Ala Glu Leu Val His Phe Leu Leu His Lys Tyr Arg Val Lys Glu Pro 
        115                 120                 125             


Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys Asn Tyr Lys Arg 
    130                 135                 140                 


Tyr Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Phe Met Gln Val Ile 
145                 150                 155                 160 


Phe Gly Thr Asp Val Lys Glu Val Asp Pro Ala Gly His Ser Tyr Ile 
                165                 170                 175     


Leu Val Thr Ala Leu Gly Leu Ser Cys Asp Ser Met Leu Gly Asp Gly 
            180                 185                 190         


His Ser Met Pro Lys Ala Ala Leu Leu Ile Ile Val Leu Gly Val Ile 
        195                 200                 205             


Leu Thr Lys Asp Asn Cys Ala Pro Glu Glu Val Ile Trp Glu Ala Leu 
    210                 215                 220                 


Ser Val Met Gly Val Tyr Val Gly Lys Glu His Met Phe Tyr Gly Glu 
225                 230                 235                 240 


Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu 
                245                 250                 255     


Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala His Tyr Glu Phe Leu Trp 
            260                 265                 270         


Gly Ser Lys Ala His Ala Glu Thr Ser Tyr Glu Lys Val Ile Asn Tyr 
        275                 280                 285             


Leu Val Met Leu Asn Ala Arg Glu Pro Ile Cys Tyr Pro Ser Leu Tyr 
    290                 295                 300                 


Glu Glu Val Leu Gly Glu Glu Gln Glu Gly Val 
305                 310                 315 


<210>  293
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Pro Pro Val Pro Gly Val Pro Phe Arg Asn Val Asp Asn Asp Ser 
1               5                   10                  15      


Pro Thr Ser Val Glu Leu Glu Asp Trp Val Asp Ala Gln His Pro Thr 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Ala Ser Ser Ala Ser Ser Thr Leu Tyr Leu 
        35                  40                  45              


Val Phe Ser Pro Ser Ser Phe Ser Thr Ser Ser Ser Leu Ile Leu Gly 
    50                  55                  60                  


Gly Pro Glu Glu Glu Glu Val Pro Ser Gly Val Ile Pro Asn Leu Thr 
65                  70                  75                  80  


Glu Ser Ile Pro Ser Ser Pro Pro Gln Gly Pro Pro Gln Gly Pro Ser 
                85                  90                  95      


Gln Ser Pro Leu Ser Ser Cys Cys Ser Ser Phe Ser Trp Ser Ser Phe 
            100                 105                 110         


Ser Glu Glu Ser Ser Ser Gln Lys Gly Glu Asp Thr Gly Thr Cys Gln 
        115                 120                 125             


Gly Leu Pro Asp Ser Glu Ser Ser Phe Thr Tyr Thr Leu Asp Glu Lys 
    130                 135                 140                 


Val Ala Glu Leu Val Glu Phe Leu Leu Leu Lys Tyr Glu Ala Glu Glu 
145                 150                 155                 160 


Pro Val Thr Glu Ala Glu Met Leu Met Ile Val Ile Lys Tyr Lys Asp 
                165                 170                 175     


Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
            180                 185                 190         


Phe Gly Leu Ala Leu Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
        195                 200                 205             


Ala Asn Thr Val Gly Leu Thr Asp Glu Gly Ser Asp Asp Glu Gly Met 
    210                 215                 220                 


Pro Glu Asn Ser Leu Leu Ile Ile Ile Leu Ser Val Ile Phe Ile Lys 
225                 230                 235                 240 


Gly Asn Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Val 
                245                 250                 255     


Gly Val Tyr Ala Gly Arg Glu His Phe Val Tyr Gly Glu Pro Arg Glu 
            260                 265                 270         


Leu Leu Thr Lys Val Trp Val Gln Gly His Tyr Leu Glu Tyr Arg Glu 
        275                 280                 285             


Val Pro His Ser Ser Pro Pro Tyr Tyr Glu Phe Leu Trp Gly Pro Arg 
    290                 295                 300                 


Ala His Ser Glu Ser Ile Lys Lys Lys Val Leu Glu Phe Leu Ala Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Val Pro Ser Ser Phe Pro Ser Trp Tyr Lys Asp Ala 
                325                 330                 335     


Leu Lys Asp Val Glu Glu Arg Val Gln Ala Thr Ile Asp Thr Ala Asp 
            340                 345                 350         


Asp Ala Thr Val Met Ala Ser Glu Ser Leu Ser Val Met Ser Ser Asn 
        355                 360                 365             


Val Ser Phe Ser Glu 
    370             


<210>  294
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Ala Gln Lys Met Asp Cys Gly Ala Gly Leu Leu Gly Phe Gln Asn 
1               5                   10                  15      


Pro Asp Ala Cys Arg Ala Val Cys His Pro Leu Pro Gln Pro Pro Ala 
            20                  25                  30          


Ser Thr Leu Pro Leu Ser Ala Phe Pro Thr Leu Cys Asp Pro Pro Tyr 
        35                  40                  45              


Ser Gln Leu Arg Asp Pro Pro Ala Val Leu Ser Cys Tyr Cys Thr Pro 
    50                  55                  60                  


Leu Gly Ala Ser Pro Ala Pro Ala Glu Ala Ser Val Glu Asp Ser Ala 
65                  70                  75                  80  


Leu Leu Met Gln Thr Leu Met Glu Ala Ile Gln Ile Ser Glu Ala Pro 
                85                  90                  95      


Pro Thr Asn Gln Ala Thr Ala Ala Ala Ser Pro Gln Ser Ser Gln Pro 
            100                 105                 110         


Pro Thr Ala Asn Glu Met Ala Asp Ile Gln Val Ser Ala Ala Ala Ala 
        115                 120                 125             


Arg Pro Lys Ser Ala Phe Lys Val Gln Asn Ala Thr Thr Lys Gly Pro 
    130                 135                 140                 


Asn Gly Val Tyr Asp Phe Ser Gln Ala His Asn Ala Lys Asp Val Pro 
145                 150                 155                 160 


Asn Thr Gln Pro Lys Ala Ala Phe Lys Ser Gln Asn Ala Thr Pro Lys 
                165                 170                 175     


Gly Pro Asn Ala Ala Tyr Asp Phe Ser Gln Ala Ala Thr Thr Gly Glu 
            180                 185                 190         


Leu Ala Ala Asn Lys Ser Glu Met Ala Phe Lys Ala Gln Asn Ala Thr 
        195                 200                 205             


Thr Lys Val Gly Pro Asn Ala Thr Tyr Asn Phe Ser Gln Ser Leu Asn 
    210                 215                 220                 


Ala Asn Asp Leu Ala Asn Ser Arg Pro Lys Thr Pro Phe Lys Ala Trp 
225                 230                 235                 240 


Asn Asp Thr Thr Lys Ala Pro Thr Ala Asp Thr Gln Thr Gln Asn Val 
                245                 250                 255     


Asn Gln Ala Lys Met Ala Thr Ser Gln Ala Asp Ile Glu Thr Asp Pro 
            260                 265                 270         


Gly Ile Ser Glu Pro Asp Gly Ala Thr Ala Gln Thr Ser Ala Asp Gly 
        275                 280                 285             


Ser Gln Ala Gln Asn Leu Glu Ser Arg Thr Ile Ile Arg Gly Lys Arg 
    290                 295                 300                 


Thr Arg Lys Ile Asn Asn Leu Asn Val Glu Glu Asn Ser Ser Gly Asp 
305                 310                 315                 320 


Gln Arg Arg Ala Pro Leu Ala Ala Gly Thr Trp Arg Ser Ala Pro Val 
                325                 330                 335     


Pro Val Thr Thr Gln Asn Pro Pro Gly Ala Pro Pro Asn Val Leu Trp 
            340                 345                 350         


Gln Thr Pro Leu Ala Trp Gln Asn Pro Ser Gly Trp Gln Asn Gln Thr 
        355                 360                 365             


Ala Arg Gln Thr Pro Pro Ala Arg Gln Ser Pro Pro Ala Arg Gln Thr 
    370                 375                 380                 


Pro Pro Ala Trp Gln Asn Pro Val Ala Trp Gln Asn Pro Val Ile Trp 
385                 390                 395                 400 


Pro Asn Pro Val Ile Trp Gln Asn Pro Val Ile Trp Pro Asn Pro Ile 
                405                 410                 415     


Val Trp Pro Gly Pro Val Val Trp Pro Asn Pro Leu Ala Trp Gln Asn 
            420                 425                 430         


Pro Pro Gly Trp Gln Thr Pro Pro Gly Trp Gln Thr Pro Pro Gly Trp 
        435                 440                 445             


Gln Gly Pro Pro Asp Trp Gln Gly Pro Pro Asp Trp Pro Leu Pro Pro 
    450                 455                 460                 


Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu Pro Thr Asp Trp Pro Leu 
465                 470                 475                 480 


Pro Pro Asp Trp Ile Pro Ala Asp Trp Pro Ile Pro Pro Asp Trp Gln 
                485                 490                 495     


Asn Leu Arg Pro Ser Pro Asn Leu Arg Pro Ser Pro Asn Ser Arg Ala 
            500                 505                 510         


Ser Gln Asn Pro Gly Ala Ala Gln Pro Arg Asp Val Ala Leu Leu Gln 
        515                 520                 525             


Glu Arg Ala Asn Lys Leu Val Lys Tyr Leu Met Leu Lys Asp Tyr Thr 
    530                 535                 540                 


Lys Val Pro Ile Lys Arg Ser Glu Met Leu Arg Asp Ile Ile Arg Glu 
545                 550                 555                 560 


Tyr Thr Asp Val Tyr Pro Glu Ile Ile Glu Arg Ala Cys Phe Val Leu 
                565                 570                 575     


Glu Lys Lys Phe Gly Ile Gln Leu Lys Glu Ile Asp Lys Glu Glu His 
            580                 585                 590         


Leu Tyr Ile Leu Ile Ser Thr Pro Glu Ser Leu Ala Gly Ile Leu Gly 
        595                 600                 605             


Thr Thr Lys Asp Thr Pro Lys Leu Gly Leu Leu Leu Val Ile Leu Gly 
    610                 615                 620                 


Val Ile Phe Met Asn Gly Asn Arg Ala Ser Glu Ala Val Leu Trp Glu 
625                 630                 635                 640 


Ala Leu Arg Lys Met Gly Leu Arg Pro Gly Val Arg His Pro Leu Leu 
                645                 650                 655     


Gly Asp Leu Arg Lys Leu Leu Thr Tyr Glu Phe Val Lys Gln Lys Tyr 
            660                 665                 670         


Leu Asp Tyr Arg Arg Val Pro Asn Ser Asn Pro Pro Glu Tyr Glu Phe 
        675                 680                 685             


Leu Trp Gly Leu Arg Ser Tyr His Glu Thr Ser Lys Met Lys Val Leu 
    690                 695                 700                 


Arg Phe Ile Ala Glu Val Gln Lys Arg Asp Pro Arg Asp Trp Thr Ala 
705                 710                 715                 720 


Gln Phe Met Glu Ala Ala Asp Glu Ala Leu Asp Ala Leu Asp Ala Ala 
                725                 730                 735     


Ala Ala Glu Ala Glu Ala Arg Ala Glu Ala Arg Thr Arg Met Gly Ile 
            740                 745                 750         


Gly Asp Glu Ala Val Ser Gly Pro Trp Ser Trp Asp Asp Ile Glu Phe 
        755                 760                 765             


Glu Leu Leu Thr Trp Asp Glu Glu Gly Asp Phe Gly Asp Pro Trp Ser 
    770                 775                 780                 


Arg Ile Pro Phe Thr Phe Trp Ala Arg Tyr His Gln Asn Ala Arg Ser 
785                 790                 795                 800 


Arg Phe Pro Gln Thr Phe Ala Gly Pro Ile Ile Gly Pro Gly Gly Thr 
                805                 810                 815     


Ala Ser Ala Asn Phe Ala Ala Asn Phe Gly Ala Ile Gly Phe Phe Trp 
            820                 825                 830         


Val Glu 
        


<210>  295
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Ala Gln Lys Met Asp Cys Gly Ala Gly Leu Leu Gly Phe Gln Ala 
1               5                   10                  15      


Glu Ala Ser Val Glu Asp Ser Ala Leu Leu Met Gln Thr Leu Met Glu 
            20                  25                  30          


Ala Ile Gln Ile Ser Glu Ala Pro Pro Thr Asn Gln Ala Thr Ala Ala 
        35                  40                  45              


Ala Ser Pro Gln Ser Ser Gln Pro Pro Thr Ala Asn Glu Met Ala Asp 
    50                  55                  60                  


Ile Gln Val Ser Ala Ala Ala Ala Arg Pro Lys Ser Ala Phe Lys Val 
65                  70                  75                  80  


Gln Asn Ala Thr Thr Lys Gly Pro Asn Gly Val Tyr Asp Phe Ser Gln 
                85                  90                  95      


Ala His Asn Ala Lys Asp Val Pro Asn Thr Gln Pro Lys Ala Ala Phe 
            100                 105                 110         


Lys Ser Gln Asn Ala Thr Pro Lys Gly Pro Asn Ala Ala Tyr Asp Phe 
        115                 120                 125             


Ser Gln Ala Ala Thr Thr Gly Glu Leu Ala Ala Asn Lys Ser Glu Met 
    130                 135                 140                 


Ala Phe Lys Ala Gln Asn Ala Thr Thr Lys Val Gly Pro Asn Ala Thr 
145                 150                 155                 160 


Tyr Asn Phe Ser Gln Ser Leu Asn Ala Asn Asp Leu Ala Asn Ser Arg 
                165                 170                 175     


Pro Lys Thr Pro Phe Lys Ala Trp Asn Asp Thr Thr Lys Ala Pro Thr 
            180                 185                 190         


Ala Asp Thr Gln Thr Gln Asn Val Asn Gln Ala Lys Met Ala Thr Ser 
        195                 200                 205             


Gln Ala Asp Ile Glu Thr Asp Pro Gly Ile Ser Glu Pro Asp Gly Ala 
    210                 215                 220                 


Thr Ala Gln Thr Ser Ala Asp Gly Ser Gln Ala Gln Asn Leu Glu Ser 
225                 230                 235                 240 


Arg Thr Ile Ile Arg Gly Lys Arg Thr Arg Lys Ile Asn Asn Leu Asn 
                245                 250                 255     


Val Glu Glu Asn Ser Ser Gly Asp Gln Arg Arg Ala Pro Leu Ala Ala 
            260                 265                 270         


Gly Thr Trp Arg Ser Ala Pro Val Pro Val Thr Thr Gln Asn Pro Pro 
        275                 280                 285             


Gly Ala Pro Pro Asn Val Leu Trp Gln Thr Pro Leu Ala Trp Gln Asn 
    290                 295                 300                 


Pro Ser Gly Trp Gln Asn Gln Thr Ala Arg Gln Thr Pro Pro Ala Arg 
305                 310                 315                 320 


Gln Ser Pro Pro Ala Arg Gln Thr Pro Pro Ala Trp Gln Asn Pro Val 
                325                 330                 335     


Ala Trp Gln Asn Pro Val Ile Trp Pro Asn Pro Val Ile Trp Gln Asn 
            340                 345                 350         


Pro Val Ile Trp Pro Asn Pro Ile Val Trp Pro Gly Pro Val Val Trp 
        355                 360                 365             


Pro Asn Pro Leu Ala Trp Gln Asn Pro Pro Gly Trp Gln Thr Pro Pro 
    370                 375                 380                 


Gly Trp Gln Thr Pro Pro Gly Trp Gln Gly Pro Pro Asp Trp Gln Gly 
385                 390                 395                 400 


Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp Pro Leu Pro Pro Asp Trp 
                405                 410                 415     


Pro Leu Pro Thr Asp Trp Pro Leu Pro Pro Asp Trp Ile Pro Ala Asp 
            420                 425                 430         


Trp Pro Ile Pro Pro Asp Trp Gln Asn Leu Arg Pro Ser Pro Asn Leu 
        435                 440                 445             


Arg Pro Ser Pro Asn Ser Arg Ala Ser Gln Asn Pro Gly Ala Ala Gln 
    450                 455                 460                 


Pro Arg Asp Val Ala Leu Leu Gln Glu Arg Ala Asn Lys Leu Val Lys 
465                 470                 475                 480 


Tyr Leu Met Leu Lys Asp Tyr Thr Lys Val Pro Ile Lys Arg Ser Glu 
                485                 490                 495     


Met Leu Arg Asp Ile Ile Arg Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
            500                 505                 510         


Ile Glu Arg Ala Cys Phe Val Leu Glu Lys Lys Phe Gly Ile Gln Leu 
        515                 520                 525             


Lys Glu Ile Asp Lys Glu Glu His Leu Tyr Ile Leu Ile Ser Thr Pro 
    530                 535                 540                 


Glu Ser Leu Ala Gly Ile Leu Gly Thr Thr Lys Asp Thr Pro Lys Leu 
545                 550                 555                 560 


Gly Leu Leu Leu Val Ile Leu Gly Val Ile Phe Met Asn Gly Asn Arg 
                565                 570                 575     


Ala Ser Glu Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly Leu Arg 
            580                 585                 590         


Pro Gly Val Arg His Pro Leu Leu Gly Asp Leu Arg Lys Leu Leu Thr 
        595                 600                 605             


Tyr Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Arg Arg Val Pro Asn 
    610                 615                 620                 


Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ser Tyr His 
625                 630                 635                 640 


Glu Thr Ser Lys Met Lys Val Leu Arg Phe Ile Ala Glu Val Gln Lys 
                645                 650                 655     


Arg Asp Pro Arg Asp Trp Thr Ala Gln Phe Met Glu Ala Ala Asp Glu 
            660                 665                 670         


Ala Leu Asp Ala Leu Asp Ala Ala Ala Ala Glu Ala Glu Ala Arg Ala 
        675                 680                 685             


Glu Ala Arg Thr Arg Met Gly Ile Gly Asp Glu Ala Val Ser Gly Pro 
    690                 695                 700                 


Trp Ser Trp Asp Asp Ile Glu Phe Glu Leu Leu Thr Trp Asp Glu Glu 
705                 710                 715                 720 


Gly Asp Phe Gly Asp Pro Trp Ser Arg Ile Pro Phe Thr Phe Trp Ala 
                725                 730                 735     


Arg Tyr His Gln Asn Ala Arg Ser Arg Phe Pro Gln Thr Phe Ala Gly 
            740                 745                 750         


Pro Ile Ile Gly Pro Gly Gly Thr Ala Ser Ala Asn Phe Ala Ala Asn 
        755                 760                 765             


Phe Gly Ala Ile Gly Phe Phe Trp Val Glu 
    770                 775             


<210>  296
<211>  1374
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Ser Thr Glu Ala Asp Glu Gly Ile Thr Phe Ser Val Pro Pro Phe 
1               5                   10                  15      


Ala Pro Ser Gly Phe Cys Thr Ile Pro Glu Gly Gly Ile Cys Arg Arg 
            20                  25                  30          


Gly Gly Ala Ala Ala Val Gly Glu Gly Glu Glu His Gln Leu Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly Ser Phe Trp Asn Val Glu Ser Ala Ala Ala Pro Gly 
    50                  55                  60                  


Ile Gly Cys Pro Ala Ala Thr Ser Ser Ser Ser Ala Thr Arg Gly Arg 
65                  70                  75                  80  


Gly Ser Ser Val Gly Gly Gly Ser Arg Arg Thr Thr Val Ala Tyr Val 
                85                  90                  95      


Ile Asn Glu Ala Ser Gln Gly Gln Leu Val Val Ala Glu Ser Glu Ala 
            100                 105                 110         


Leu Gln Ser Leu Arg Glu Ala Cys Glu Thr Val Gly Ala Thr Leu Glu 
        115                 120                 125             


Thr Leu His Phe Gly Lys Leu Asp Phe Gly Glu Thr Thr Val Leu Asp 
    130                 135                 140                 


Arg Phe Tyr Asn Ala Asp Ile Ala Val Val Glu Met Ser Asp Ala Phe 
145                 150                 155                 160 


Arg Gln Pro Ser Leu Phe Tyr His Leu Gly Val Arg Glu Ser Phe Ser 
                165                 170                 175     


Met Ala Asn Asn Ile Ile Leu Tyr Cys Asp Thr Asn Ser Asp Ser Leu 
            180                 185                 190         


Gln Ser Leu Lys Glu Ile Ile Cys Gln Lys Asn Thr Met Cys Thr Gly 
        195                 200                 205             


Asn Tyr Thr Phe Val Pro Tyr Met Ile Thr Pro His Asn Lys Val Tyr 
    210                 215                 220                 


Cys Cys Asp Ser Ser Phe Met Lys Gly Leu Thr Glu Leu Met Gln Pro 
225                 230                 235                 240 


Asn Phe Glu Leu Leu Leu Gly Pro Ile Cys Leu Pro Leu Val Asp Arg 
                245                 250                 255     


Phe Ile Gln Leu Leu Lys Val Ala Gln Ala Ser Ser Ser Gln Tyr Phe 
            260                 265                 270         


Arg Glu Ser Ile Leu Asn Asp Ile Arg Lys Ala Arg Asn Leu Tyr Thr 
        275                 280                 285             


Gly Lys Glu Leu Ala Ala Glu Leu Ala Arg Ile Arg Gln Arg Val Asp 
    290                 295                 300                 


Asn Ile Glu Val Leu Thr Ala Asp Ile Val Ile Asn Leu Leu Leu Ser 
305                 310                 315                 320 


Tyr Arg Asp Ile Gln Asp Tyr Asp Ser Ile Val Lys Leu Val Glu Thr 
                325                 330                 335     


Leu Glu Lys Leu Pro Thr Phe Asp Leu Ala Ser His His His Val Lys 
            340                 345                 350         


Phe His Tyr Ala Phe Ala Leu Asn Arg Arg Asn Leu Pro Gly Asp Arg 
        355                 360                 365             


Ala Lys Ala Leu Asp Ile Met Ile Pro Met Val Gln Ser Glu Gly Gln 
    370                 375                 380                 


Val Ala Ser Asp Met Tyr Cys Leu Val Gly Arg Ile Tyr Lys Asp Met 
385                 390                 395                 400 


Phe Leu Asp Ser Asn Phe Thr Asp Thr Glu Ser Arg Asp His Gly Ala 
                405                 410                 415     


Ser Trp Phe Lys Lys Ala Phe Glu Ser Glu Pro Thr Leu Gln Ser Gly 
            420                 425                 430         


Ile Asn Tyr Ala Val Leu Leu Leu Ala Ala Gly His Gln Phe Glu Ser 
        435                 440                 445             


Ser Phe Glu Leu Arg Lys Val Gly Val Lys Leu Ser Ser Leu Leu Gly 
    450                 455                 460                 


Lys Lys Gly Asn Leu Glu Lys Leu Gln Ser Tyr Trp Glu Val Gly Phe 
465                 470                 475                 480 


Phe Leu Gly Ala Ser Val Leu Ala Asn Asp His Met Arg Val Ile Gln 
                485                 490                 495     


Ala Ser Glu Lys Leu Phe Lys Leu Lys Thr Pro Ala Trp Tyr Leu Lys 
            500                 505                 510         


Ser Ile Val Glu Thr Ile Leu Ile Tyr Lys His Phe Val Lys Leu Thr 
        515                 520                 525             


Thr Glu Gln Pro Val Ala Lys Gln Glu Leu Val Asp Phe Trp Met Asp 
    530                 535                 540                 


Phe Leu Val Glu Ala Thr Lys Thr Asp Val Thr Val Val Arg Phe Pro 
545                 550                 555                 560 


Val Leu Ile Leu Glu Pro Thr Lys Ile Tyr Gln Pro Ser Tyr Leu Ser 
                565                 570                 575     


Ile Asn Asn Glu Val Glu Glu Lys Thr Ile Ser Ile Trp His Val Leu 
            580                 585                 590         


Pro Asp Asp Lys Lys Gly Ile His Glu Trp Asn Phe Ser Ala Ser Ser 
        595                 600                 605             


Val Arg Gly Val Ser Ile Ser Lys Phe Glu Glu Arg Cys Cys Phe Leu 
    610                 615                 620                 


Tyr Val Leu His Asn Ser Asp Asp Phe Gln Ile Tyr Phe Cys Thr Glu 
625                 630                 635                 640 


Leu His Cys Lys Lys Phe Phe Glu Met Val Asn Thr Ile Thr Glu Glu 
                645                 650                 655     


Lys Gly Arg Ser Thr Glu Glu Gly Asp Cys Glu Ser Asp Leu Leu Glu 
            660                 665                 670         


Tyr Asp Tyr Glu Tyr Asp Glu Asn Gly Asp Arg Val Val Leu Gly Lys 
        675                 680                 685             


Gly Thr Tyr Gly Ile Val Tyr Ala Gly Arg Asp Leu Ser Asn Gln Val 
    690                 695                 700                 


Arg Ile Ala Ile Lys Glu Ile Pro Glu Arg Asp Ser Arg Tyr Ser Gln 
705                 710                 715                 720 


Pro Leu His Glu Glu Ile Ala Leu His Lys His Leu Lys His Lys Asn 
                725                 730                 735     


Ile Val Gln Tyr Leu Gly Ser Phe Ser Glu Asn Gly Phe Ile Lys Ile 
            740                 745                 750         


Phe Met Glu Gln Val Pro Gly Gly Ser Leu Ser Ala Leu Leu Arg Ser 
        755                 760                 765             


Lys Trp Gly Pro Leu Lys Asp Asn Glu Gln Thr Ile Gly Phe Tyr Thr 
    770                 775                 780                 


Lys Gln Ile Leu Glu Gly Leu Lys Tyr Leu His Asp Asn Gln Ile Val 
785                 790                 795                 800 


His Arg Asp Ile Lys Gly Asp Asn Val Leu Ile Asn Thr Tyr Ser Gly 
                805                 810                 815     


Val Leu Lys Ile Ser Asp Phe Gly Thr Ser Lys Arg Leu Ala Gly Ile 
            820                 825                 830         


Asn Pro Cys Thr Glu Thr Phe Thr Gly Thr Leu Gln Tyr Met Ala Pro 
        835                 840                 845             


Glu Ile Ile Asp Lys Gly Pro Arg Gly Tyr Gly Lys Ala Ala Asp Ile 
    850                 855                 860                 


Trp Ser Leu Gly Cys Thr Ile Ile Glu Met Ala Thr Gly Lys Pro Pro 
865                 870                 875                 880 


Phe Tyr Glu Leu Gly Glu Pro Gln Ala Ala Met Phe Lys Val Gly Met 
                885                 890                 895     


Phe Lys Val His Pro Glu Ile Pro Glu Ser Met Ser Ala Glu Ala Lys 
            900                 905                 910         


Ala Phe Ile Leu Lys Cys Phe Glu Pro Asp Pro Asp Lys Arg Ala Cys 
        915                 920                 925             


Ala Asn Asp Leu Leu Val Asp Glu Phe Leu Lys Val Ser Ser Lys Lys 
    930                 935                 940                 


Lys Lys Thr Gln Pro Lys Leu Ser Ala Leu Ser Ala Gly Ser Asn Glu 
945                 950                 955                 960 


Tyr Leu Arg Ser Ile Ser Leu Pro Val Pro Val Leu Val Glu Asp Thr 
                965                 970                 975     


Ser Ser Ser Ser Glu Tyr Gly Ser Val Ser Pro Asp Thr Glu Leu Lys 
            980                 985                 990         


Val Asp Pro Phe Ser Phe Lys Thr  Arg Ala Lys Ser Cys  Gly Glu Arg 
        995                 1000                 1005             


Asp Val  Lys Gly Ile Arg Thr  Leu Phe Leu Gly Ile  Pro Asp Glu 
    1010                 1015                 1020             


Asn Phe  Glu Asp His Ser Ala  Pro Pro Ser Pro Glu  Glu Lys Asp 
    1025                 1030                 1035             


Ser Gly  Phe Phe Met Leu Arg  Lys Asp Ser Glu Arg  Arg Ala Thr 
    1040                 1045                 1050             


Leu His  Arg Ile Leu Thr Glu  Asp Gln Asp Lys Ile  Val Arg Asn 
    1055                 1060                 1065             


Leu Met  Glu Ser Leu Ala Gln  Gly Ala Glu Glu Pro  Lys Leu Lys 
    1070                 1075                 1080             


Trp Glu  His Ile Thr Thr Leu  Ile Ala Ser Leu Arg  Glu Phe Val 
    1085                 1090                 1095             


Arg Ser  Thr Asp Arg Lys Ile  Ile Ala Thr Thr Leu  Ser Lys Leu 
    1100                 1105                 1110             


Lys Leu  Glu Leu Asp Phe Asp  Ser His Gly Ile Ser  Gln Val Gln 
    1115                 1120                 1125             


Val Val  Leu Phe Gly Phe Gln  Asp Ala Val Asn Lys  Val Leu Arg 
    1130                 1135                 1140             


Asn His  Asn Ile Lys Pro His  Trp Met Phe Ala Leu  Asp Ser Ile 
    1145                 1150                 1155             


Ile Arg  Lys Ala Val Gln Thr  Ala Ile Thr Ile Leu  Val Pro Glu 
    1160                 1165                 1170             


Leu Arg  Pro His Phe Ser Leu  Ala Ser Glu Ser Asp  Thr Ala Asp 
    1175                 1180                 1185             


Gln Glu  Asp Leu Asp Val Glu  Asp Asp His Glu Glu  Gln Pro Ser 
    1190                 1195                 1200             


Asn Gln  Thr Val Arg Arg Pro  Gln Ala Val Ile Glu  Asp Ala Val 
    1205                 1210                 1215             


Ala Thr  Ser Gly Val Ser Thr  Leu Ser Ser Thr Val  Ser His Asp 
    1220                 1225                 1230             


Ser Gln  Ser Ala His Arg Ser  Leu Asn Val Gln Leu  Gly Arg Met 
    1235                 1240                 1245             


Lys Ile  Glu Thr Asn Arg Leu  Leu Glu Glu Leu Val  Arg Lys Glu 
    1250                 1255                 1260             


Lys Glu  Leu Gln Ala Leu Leu  His Arg Ala Ile Glu  Glu Lys Asp 
    1265                 1270                 1275             


Gln Glu  Ile Lys His Leu Lys  Leu Lys Ser Gln Pro  Ile Glu Ile 
    1280                 1285                 1290             


Pro Glu  Leu Pro Val Phe His  Leu Asn Ser Ser Gly  Thr Asn Thr 
    1295                 1300                 1305             


Glu Asp  Ser Glu Leu Thr Asp  Trp Leu Arg Val Asn  Gly Ala Asp 
    1310                 1315                 1320             


Glu Asp  Thr Ile Ser Arg Phe  Leu Ala Glu Asp Tyr  Thr Leu Leu 
    1325                 1330                 1335             


Asp Val  Leu Tyr Tyr Val Thr  Arg Asp Asp Leu Lys  Cys Leu Arg 
    1340                 1345                 1350             


Leu Arg  Gly Gly Met Leu Cys  Thr Leu Trp Lys Ala  Ile Ile Asp 
    1355                 1360                 1365             


Phe Arg  Asn Lys Gln Thr 
    1370                 


<210>  297
<211>  1118
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Glu Pro Ser Arg Ala Leu Leu Gly Cys Leu Ala Ser Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Pro Gly Glu Asp Gly Ala Gly Ala Gly Ala Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Val Gly Pro Gly Glu Leu 
        35                  40                  45              


Gly Cys Asp Ala Pro Leu Pro Tyr Trp Thr Ala Val Phe Glu Tyr Glu 
    50                  55                  60                  


Ala Ala Gly Glu Asp Glu Leu Thr Leu Arg Leu Gly Asp Val Val Glu 
65                  70                  75                  80  


Val Leu Ser Lys Asp Ser Gln Val Ser Gly Asp Glu Gly Trp Trp Thr 
                85                  90                  95      


Gly Gln Leu Asn Gln Arg Val Gly Ile Phe Pro Ser Asn Tyr Val Thr 
            100                 105                 110         


Pro Arg Ser Ala Phe Ser Ser Arg Cys Gln Pro Gly Gly Glu Asp Pro 
        115                 120                 125             


Ser Cys Tyr Pro Pro Ile Gln Leu Leu Glu Ile Asp Phe Ala Glu Leu 
    130                 135                 140                 


Thr Leu Glu Glu Ile Ile Gly Ile Gly Gly Phe Gly Lys Val Tyr Arg 
145                 150                 155                 160 


Ala Phe Trp Ile Gly Asp Glu Val Ala Val Lys Ala Ala Arg His Asp 
                165                 170                 175     


Pro Asp Glu Asp Ile Ser Gln Thr Ile Glu Asn Val Arg Gln Glu Ala 
            180                 185                 190         


Lys Leu Phe Ala Met Leu Lys His Pro Asn Ile Ile Ala Leu Arg Gly 
        195                 200                 205             


Val Cys Leu Lys Glu Pro Asn Leu Cys Leu Val Met Glu Phe Ala Arg 
    210                 215                 220                 


Gly Gly Pro Leu Asn Arg Val Leu Ser Gly Lys Arg Ile Pro Pro Asp 
225                 230                 235                 240 


Ile Leu Val Asn Trp Ala Val Gln Ile Ala Arg Gly Met Asn Tyr Leu 
                245                 250                 255     


His Asp Glu Ala Ile Val Pro Ile Ile His Arg Asp Leu Lys Ser Ser 
            260                 265                 270         


Asn Ile Leu Ile Leu Gln Lys Val Glu Asn Gly Asp Leu Ser Asn Lys 
        275                 280                 285             


Ile Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr 
    290                 295                 300                 


Thr Lys Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val 
305                 310                 315                 320 


Ile Arg Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly 
                325                 330                 335     


Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile 
            340                 345                 350         


Asp Gly Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu 
        355                 360                 365             


Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp 
    370                 375                 380                 


Cys Trp Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu 
385                 390                 395                 400 


Asp Gln Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys 
                405                 410                 415     


Asp Ser Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu 
            420                 425                 430         


Met Phe Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu 
        435                 440                 445             


Glu Glu Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu 
    450                 455                 460                 


Leu Arg Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu 
465                 470                 475                 480 


Glu Arg Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro 
                485                 490                 495     


Arg Val Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu 
            500                 505                 510         


Lys Asp Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe 
        515                 520                 525             


Thr Val Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn 
    530                 535                 540                 


Ser Arg Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg 
545                 550                 555                 560 


Ala Ile Gln Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser 
                565                 570                 575     


Ser Val Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro 
            580                 585                 590         


Lys Lys Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu 
        595                 600                 605             


Leu Ala Ser Gly Asp Glu Gly Ser Pro Gln Arg Arg Glu Lys Ala Asn 
    610                 615                 620                 


Gly Leu Ser Thr Pro Ser Glu Ser Pro His Phe His Leu Gly Leu Lys 
625                 630                 635                 640 


Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro Asn Leu 
                645                 650                 655     


Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr Ser Leu 
            660                 665                 670         


Met Glu Met Ala Leu Leu Ala Ala Ser Trp Val Val Pro Ile Asp Ile 
        675                 680                 685             


Glu Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser Arg Leu 
    690                 695                 700                 


Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro Arg Gly 
705                 710                 715                 720 


Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu Pro Thr 
                725                 730                 735     


Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr Asn Ser 
            740                 745                 750         


Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala Leu Leu 
        755                 760                 765             


Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp Leu Leu 
    770                 775                 780                 


Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu Pro Pro 
785                 790                 795                 800 


Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg Ser Ser 
                805                 810                 815     


Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe Lys Lys 
            820                 825                 830         


Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu Thr Leu 
        835                 840                 845             


Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser Leu Leu 
    850                 855                 860                 


Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val Ser Pro 
865                 870                 875                 880 


Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu Val Asn 
                885                 890                 895     


Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu Thr Pro 
            900                 905                 910         


Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His Arg Arg 
        915                 920                 925             


Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala Ser Arg 
    930                 935                 940                 


Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly Met Leu 
945                 950                 955                 960 


Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg Leu Pro 
                965                 970                 975     


Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn Thr Gln 
            980                 985                 990         


Gln Asp Ser Thr Leu Glu Arg Pro  Lys Thr Leu Glu Phe  Leu Pro Arg 
        995                 1000                 1005             


Pro Arg  Pro Ser Ala Asn Arg  Gln Arg Leu Asp Pro  Trp Trp Phe 
    1010                 1015                 1020             


Val Ser  Pro Ser His Ala Arg  Ser Thr Ser Pro Ala  Asn Ser Ser 
    1025                 1030                 1035             


Ser Thr  Glu Thr Pro Ser Asn  Leu Asp Ser Cys Phe  Ala Ser Ser 
    1040                 1045                 1050             


Ser Ser  Thr Val Glu Glu Arg  Pro Gly Leu Pro Ala  Leu Leu Pro 
    1055                 1060                 1065             


Phe Gln  Ala Gly Pro Leu Pro  Pro Thr Glu Arg Thr  Leu Leu Asp 
    1070                 1075                 1080             


Leu Asp  Ala Glu Gly Gln Ser  Gln Asp Ser Thr Val  Pro Leu Cys 
    1085                 1090                 1095             


Arg Ala  Glu Leu Asn Thr His  Arg Pro Ala Pro Tyr  Glu Ile Gln 
    1100                 1105                 1110             


Gln Glu  Phe Trp Ser 
    1115             


<210>  298
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Glu Pro Ser Arg Ala Leu Leu Gly Cys Leu Ala Ser Ala Ala Ala 
1               5                   10                  15      


Ala Ala Pro Pro Gly Glu Asp Gly Ala Gly Ala Gly Ala Glu Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Val Gly Pro Gly Glu Leu 
        35                  40                  45              


Gly Cys Asp Ala Pro Leu Pro Tyr Trp Thr Ala Val Phe Glu Tyr Glu 
    50                  55                  60                  


Ala Ala Gly Glu Asp Glu Leu Thr Leu Arg Leu Gly Asp Val Val Glu 
65                  70                  75                  80  


Val Leu Ser Lys Asp Ser Gln Val Ser Gly Asp Glu Gly Trp Trp Thr 
                85                  90                  95      


Gly Gln Leu Asn Gln Arg Val Gly Ile Phe Pro Ser Asn Tyr Val Thr 
            100                 105                 110         


Pro Arg Ser Ala Phe Ser Ser Arg Cys Gln Pro Gly Gly Glu Asp Pro 
        115                 120                 125             


Ser Cys Tyr Pro Pro Ile Gln Leu Leu Glu Ile Asp Phe Ala Glu Leu 
    130                 135                 140                 


Thr Leu Glu Glu Ile Ile Gly Ile Gly Gly Phe Gly Lys Val Tyr Arg 
145                 150                 155                 160 


Ala Phe Trp Ile Gly Asp Glu Val Ala Val Lys Ala Ala Arg His Asp 
                165                 170                 175     


Pro Asp Glu Asp Ile Ser Gln Thr Ile Glu Asn Val Arg Gln Glu Ala 
            180                 185                 190         


Lys Leu Phe Ala Met Leu Lys His Pro Asn Ile Ile Ala Leu Arg Gly 
        195                 200                 205             


Val Cys Leu Lys Glu Pro Asn Leu Cys Leu Val Met Glu Phe Ala Arg 
    210                 215                 220                 


Gly Gly Pro Leu Asn Arg Val Leu Ser Gly Lys Arg Ile Pro Pro Asp 
225                 230                 235                 240 


Ile Leu Val Asn Trp Ala Val Gln Ile Ala Arg Gly Met Asn Tyr Leu 
                245                 250                 255     


His Asp Glu Ala Ile Val Pro Ile Ile His Arg Asp Leu Lys Ser Ser 
            260                 265                 270         


Asn Ile Leu Ile Leu Gln Lys Val Glu Asn Gly Asp Leu Ser Asn Lys 
        275                 280                 285             


Ile Leu Lys Ile Thr Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr 
    290                 295                 300                 


Thr Lys Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val 
305                 310                 315                 320 


Ile Arg Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly 
                325                 330                 335     


Val Leu Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile 
            340                 345                 350         


Asp Gly Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu 
        355                 360                 365             


Pro Ile Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp 
    370                 375                 380                 


Cys Trp Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu 
385                 390                 395                 400 


Asp Gln Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys 
                405                 410                 415     


Asp Ser Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu 
            420                 425                 430         


Met Phe Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu 
        435                 440                 445             


Glu Glu Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu 
    450                 455                 460                 


Leu Arg Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu 
465                 470                 475                 480 


Glu Arg Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro 
                485                 490                 495     


Arg Val Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu 
            500                 505                 510         


Lys Asp Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe 
        515                 520                 525             


Thr Val Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn 
    530                 535                 540                 


Ser Arg Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg 
545                 550                 555                 560 


Ala Ile Gln Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser 
                565                 570                 575     


Ser Val Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro 
            580                 585                 590         


Lys Lys Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu 
        595                 600                 605             


Leu Ala Ser Gly Asp Glu Gly Ser Pro Gln Arg Arg Glu Lys Ala Asn 
    610                 615                 620                 


Gly Leu Ser Thr Pro Ser Glu Ser Pro His Phe His Leu Gly Leu Lys 
625                 630                 635                 640 


Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro Asn Leu 
                645                 650                 655     


Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr Ser Leu 
            660                 665                 670         


Met Glu Met Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser 
        675                 680                 685             


Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro 
    690                 695                 700                 


Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu 
705                 710                 715                 720 


Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr 
                725                 730                 735     


Asn Ser Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala 
            740                 745                 750         


Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp 
        755                 760                 765             


Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu 
    770                 775                 780                 


Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg 
785                 790                 795                 800 


Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe 
                805                 810                 815     


Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu 
            820                 825                 830         


Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser 
        835                 840                 845             


Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val 
    850                 855                 860                 


Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu 
865                 870                 875                 880 


Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu 
                885                 890                 895     


Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His 
            900                 905                 910         


Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala 
        915                 920                 925             


Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly 
    930                 935                 940                 


Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg 
945                 950                 955                 960 


Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn 
                965                 970                 975     


Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys Thr Leu Glu Phe Leu 
            980                 985                 990         


Pro Arg Pro Arg Pro Ser Ala Asn  Arg Gln Arg Leu Asp  Pro Trp Trp 
        995                 1000                 1005             


Phe Val  Ser Pro Ser His Ala  Arg Ser Thr Ser Pro  Ala Asn Ser 
    1010                 1015                 1020             


Ser Ser  Thr Glu Thr Pro Ser  Asn Leu Asp Ser Cys  Phe Ala Ser 
    1025                 1030                 1035             


Ser Ser  Ser Thr Val Glu Glu  Arg Pro Gly Leu Pro  Ala Leu Leu 
    1040                 1045                 1050             


Pro Phe  Gln Ala Gly Pro Leu  Pro Pro Thr Glu Arg  Thr Leu Leu 
    1055                 1060                 1065             


Asp Leu  Asp Ala Glu Gly Gln  Ser Gln Asp Ser Thr  Val Pro Leu 
    1070                 1075                 1080             


Cys Arg  Ala Glu Leu Asn Thr  His Arg Pro Ala Pro  Tyr Glu Ile 
    1085                 1090                 1095             


Gln Gln  Glu Phe Trp Ser 
    1100                 


<210>  299
<211>  880
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Glu Leu Thr Gly Leu Glu Val Ala Leu Val Leu Ile Leu Gln Lys 
1               5                   10                  15      


Val Glu Asn Gly Asp Leu Ser Asn Lys Ile Leu Lys Ile Thr Asp Phe 
            20                  25                  30          


Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser Ala Ala Gly 
        35                  40                  45              


Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Arg Ala Ser Met Phe Ser 
    50                  55                  60                  


Lys Gly Ser Asp Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Leu Leu 
65                  70                  75                  80  


Thr Gly Glu Val Pro Phe Arg Gly Ile Asp Gly Leu Ala Val Ala Tyr 
                85                  90                  95      


Gly Val Ala Met Asn Lys Leu Ala Leu Pro Ile Pro Ser Thr Cys Pro 
            100                 105                 110         


Glu Pro Phe Ala Lys Leu Met Glu Asp Cys Trp Asn Pro Asp Pro His 
        115                 120                 125             


Ser Arg Pro Ser Phe Thr Asn Ile Leu Asp Gln Leu Thr Thr Ile Glu 
    130                 135                 140                 


Glu Ser Gly Phe Phe Glu Met Pro Lys Asp Ser Phe His Cys Leu Gln 
145                 150                 155                 160 


Asp Asn Trp Lys His Glu Ile Gln Glu Met Phe Asp Gln Leu Arg Ala 
                165                 170                 175     


Lys Glu Lys Glu Leu Arg Thr Trp Glu Glu Glu Leu Thr Arg Ala Ala 
            180                 185                 190         


Leu Gln Gln Lys Asn Gln Glu Glu Leu Leu Arg Arg Arg Glu Gln Glu 
        195                 200                 205             


Leu Ala Glu Arg Glu Ile Asp Ile Leu Glu Arg Glu Leu Asn Ile Ile 
    210                 215                 220                 


Ile His Gln Leu Cys Gln Glu Lys Pro Arg Val Lys Lys Arg Lys Gly 
225                 230                 235                 240 


Lys Phe Arg Lys Ser Arg Leu Lys Leu Lys Asp Gly Asn Arg Ile Ser 
                245                 250                 255     


Leu Pro Ser Asp Phe Gln His Lys Phe Thr Val Gln Ala Ser Pro Thr 
            260                 265                 270         


Met Asp Lys Arg Lys Ser Leu Ile Asn Ser Arg Ser Ser Pro Pro Ala 
        275                 280                 285             


Ser Pro Thr Ile Ile Pro Arg Leu Arg Ala Ile Gln Cys Glu Thr Val 
    290                 295                 300                 


Ser Gln Ile Ser Trp Gly Gln Asn Thr Gln Gly His Leu Ser Pro Ala 
305                 310                 315                 320 


Leu Ser Ser His Arg Leu Val Gln Ala Cys Ser Ile His Asn Phe Cys 
                325                 330                 335     


His Leu Ser Ser Thr Met Cys Ile Tyr Met His Ile Leu Thr Pro Gly 
            340                 345                 350         


Glu Ser Ser Lys Thr Trp Gly Arg Ser Ser Val Val Pro Lys Glu Glu 
        355                 360                 365             


Gly Glu Glu Glu Glu Lys Arg Ala Pro Lys Lys Lys Gly Arg Thr Trp 
    370                 375                 380                 


Gly Pro Gly Thr Leu Gly Gln Lys Glu Leu Ala Ser Gly Asp Glu Gly 
385                 390                 395                 400 


Leu Lys Ser Leu Val Asp Gly Tyr Lys Gln Trp Ser Ser Ser Ala Pro 
                405                 410                 415     


Asn Leu Val Lys Gly Pro Arg Ser Ser Pro Ala Leu Pro Gly Phe Thr 
            420                 425                 430         


Ser Leu Met Glu Met Ala Leu Leu Ala Ala Ser Trp Val Val Pro Ile 
        435                 440                 445             


Asp Ile Glu Glu Asp Glu Asp Ser Glu Gly Pro Gly Ser Gly Glu Ser 
    450                 455                 460                 


Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu Cys Ile Pro Phe Pro 
465                 470                 475                 480 


Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp Gly Ile His Glu Glu 
                485                 490                 495     


Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro Gln Leu Thr Pro Thr 
            500                 505                 510         


Asn Ser Leu Lys Arg Gly Gly Ala His His Arg Arg Cys Glu Val Ala 
        515                 520                 525             


Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr Gly Leu Gly Phe Asp 
    530                 535                 540                 


Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro Leu Glu Glu Pro Glu 
545                 550                 555                 560 


Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu Gly Leu Phe Gln Arg 
                565                 570                 575     


Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro Ser Arg Lys Leu Phe 
            580                 585                 590         


Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp Pro Ser Ala Ser Leu 
        595                 600                 605             


Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys Asn Ser Thr Arg Ser 
    610                 615                 620                 


Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val Tyr Glu Met Pro Val 
625                 630                 635                 640 


Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys Thr His Asn Pro Leu 
                645                 650                 655     


Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp Pro Asn Gln Ser Leu 
            660                 665                 670         


Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser Gln Pro Ser Ser His 
        675                 680                 685             


Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro Glu Thr Leu Leu Ala 
    690                 695                 700                 


Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro Ser Pro Gly Ala Gly 
705                 710                 715                 720 


Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro Gly Glu Phe Pro Arg 
                725                 730                 735     


Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr Pro Arg Arg Trp Asn 
            740                 745                 750         


Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys Thr Leu Glu Phe Leu 
        755                 760                 765             


Pro Arg Pro Arg Pro Ser Ala Asn Arg Gln Arg Leu Asp Pro Trp Trp 
    770                 775                 780                 


Phe Val Ser Pro Ser His Ala Arg Ser Thr Ser Pro Ala Asn Ser Ser 
785                 790                 795                 800 


Ser Thr Glu Thr Pro Ser Asn Leu Asp Ser Cys Phe Ala Ser Ser Ser 
                805                 810                 815     


Ser Thr Val Glu Glu Arg Pro Gly Leu Pro Ala Leu Leu Pro Phe Gln 
            820                 825                 830         


Ala Gly Pro Leu Pro Pro Thr Glu Arg Thr Leu Leu Asp Leu Asp Ala 
        835                 840                 845             


Glu Gly Gln Ser Gln Asp Ser Thr Val Pro Leu Cys Arg Ala Glu Leu 
    850                 855                 860                 


Asn Thr His Arg Pro Ala Pro Tyr Glu Ile Gln Gln Glu Phe Trp Ser 
865                 870                 875                 880 


<210>  300
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ser Ala Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Arg 
1               5                   10                  15      


Ala Ser Met Phe Ser Lys Gly Ser Asp Val Trp Ser Tyr Gly Val Leu 
            20                  25                  30          


Leu Trp Glu Leu Leu Thr Gly Glu Val Pro Phe Arg Gly Ile Asp Gly 
        35                  40                  45              


Leu Ala Val Ala Tyr Gly Val Ala Met Asn Lys Leu Ala Leu Pro Ile 
    50                  55                  60                  


Pro Ser Thr Cys Pro Glu Pro Phe Ala Lys Leu Met Glu Asp Cys Trp 
65                  70                  75                  80  


Asn Pro Asp Pro His Ser Arg Pro Ser Phe Thr Asn Ile Leu Asp Gln 
                85                  90                  95      


Leu Thr Thr Ile Glu Glu Ser Gly Phe Phe Glu Met Pro Lys Asp Ser 
            100                 105                 110         


Phe His Cys Leu Gln Asp Asn Trp Lys His Glu Ile Gln Glu Met Phe 
        115                 120                 125             


Asp Gln Leu Arg Ala Lys Glu Lys Glu Leu Arg Thr Trp Glu Glu Glu 
    130                 135                 140                 


Leu Thr Arg Ala Ala Leu Gln Gln Lys Asn Gln Glu Glu Leu Leu Arg 
145                 150                 155                 160 


Arg Arg Glu Gln Glu Leu Ala Glu Arg Glu Ile Asp Ile Leu Glu Arg 
                165                 170                 175     


Glu Leu Asn Ile Ile Ile His Gln Leu Cys Gln Glu Lys Pro Arg Val 
            180                 185                 190         


Lys Lys Arg Lys Gly Lys Phe Arg Lys Ser Arg Leu Lys Leu Lys Asp 
        195                 200                 205             


Gly Asn Arg Ile Ser Leu Pro Ser Asp Phe Gln His Lys Phe Thr Val 
    210                 215                 220                 


Gln Ala Ser Pro Thr Met Asp Lys Arg Lys Ser Leu Ile Asn Ser Arg 
225                 230                 235                 240 


Ser Ser Pro Pro Ala Ser Pro Thr Ile Ile Pro Arg Leu Arg Ala Ile 
                245                 250                 255     


Gln Cys Glu Thr Val Ser Gln Ile Ser Trp Gly Gln Asn Thr Gln Gly 
            260                 265                 270         


His Leu Ser Pro Ala Leu Ser Ser His Arg Leu Val Gln Ala Cys Ser 
        275                 280                 285             


Ile His Asn Phe Cys His Leu Ser Ser Thr Met Cys Ile Tyr Met His 
    290                 295                 300                 


Ile Leu Thr Pro Gly Glu Ser Ser Lys Thr Trp Gly Arg Ser Ser Val 
305                 310                 315                 320 


Val Pro Lys Glu Glu Gly Glu Glu Glu Glu Lys Arg Ala Pro Lys Lys 
                325                 330                 335     


Lys Gly Arg Thr Trp Gly Pro Gly Thr Leu Gly Gln Lys Glu Leu Ala 
            340                 345                 350         


Ser Gly Asp Glu Gly Leu Lys Ser Leu Val Asp Gly Tyr Lys Gln Trp 
        355                 360                 365             


Ser Ser Ser Ala Pro Asn Leu Val Lys Gly Pro Arg Ser Ser Pro Ala 
    370                 375                 380                 


Leu Pro Gly Phe Thr Ser Leu Met Glu Met Ala Leu Leu Ala Ala Ser 
385                 390                 395                 400 


Trp Val Val Pro Ile Asp Ile Glu Glu Asp Glu Asp Ser Glu Gly Pro 
                405                 410                 415     


Gly Ser Gly Glu Ser Arg Leu Gln His Ser Pro Ser Gln Ser Tyr Leu 
            420                 425                 430         


Cys Ile Pro Phe Pro Arg Gly Glu Asp Gly Asp Gly Pro Ser Ser Asp 
        435                 440                 445             


Gly Ile His Glu Glu Pro Thr Pro Val Asn Ser Ala Thr Ser Thr Pro 
    450                 455                 460                 


Gln Leu Thr Pro Thr Asn Ser Leu Lys Arg Gly Gly Ala His His Arg 
465                 470                 475                 480 


Arg Cys Glu Val Ala Leu Leu Gly Cys Gly Ala Val Leu Ala Ala Thr 
                485                 490                 495     


Gly Leu Gly Phe Asp Leu Leu Glu Ala Gly Lys Cys Gln Leu Leu Pro 
            500                 505                 510         


Leu Glu Glu Pro Glu Pro Pro Ala Arg Glu Glu Lys Lys Arg Arg Glu 
        515                 520                 525             


Gly Leu Phe Gln Arg Ser Ser Arg Pro Arg Arg Ser Thr Ser Pro Pro 
    530                 535                 540                 


Ser Arg Lys Leu Phe Lys Lys Glu Glu Pro Met Leu Leu Leu Gly Asp 
545                 550                 555                 560 


Pro Ser Ala Ser Leu Thr Leu Leu Ser Leu Ser Ser Ile Ser Glu Cys 
                565                 570                 575     


Asn Ser Thr Arg Ser Leu Leu Arg Ser Asp Ser Asp Glu Ile Val Val 
            580                 585                 590         


Tyr Glu Met Pro Val Ser Pro Val Glu Ala Pro Pro Leu Ser Pro Cys 
        595                 600                 605             


Thr His Asn Pro Leu Val Asn Val Arg Val Glu Arg Phe Lys Arg Asp 
    610                 615                 620                 


Pro Asn Gln Ser Leu Thr Pro Thr His Val Thr Leu Thr Thr Pro Ser 
625                 630                 635                 640 


Gln Pro Ser Ser His Arg Arg Thr Pro Ser Asp Gly Ala Leu Lys Pro 
                645                 650                 655     


Glu Thr Leu Leu Ala Ser Arg Ser Pro Ser Ser Asn Gly Leu Ser Pro 
            660                 665                 670         


Ser Pro Gly Ala Gly Met Leu Lys Thr Pro Ser Pro Ser Arg Asp Pro 
        675                 680                 685             


Gly Glu Phe Pro Arg Leu Pro Asp Pro Asn Val Val Phe Pro Pro Thr 
    690                 695                 700                 


Pro Arg Arg Trp Asn Thr Gln Gln Asp Ser Thr Leu Glu Arg Pro Lys 
705                 710                 715                 720 


Thr Leu Glu Phe Leu Pro Arg Pro Arg Pro Ser Ala Asn Arg Gln Arg 
                725                 730                 735     


Leu Asp Pro Trp Trp Phe Val Ser Pro Ser His Ala Arg Ser Thr Ser 
            740                 745                 750         


Pro Ala Asn Ser Ser Ser Thr Glu Thr Pro Ser Asn Leu Asp Ser Cys 
        755                 760                 765             


Phe Ala Ser Ser Ser Ser Thr Val Glu Glu Arg Pro Gly Leu Pro Ala 
    770                 775                 780                 


Leu Leu Pro Phe Gln Ala Gly Pro Leu Pro Pro Thr Glu Arg Thr Leu 
785                 790                 795                 800 


Leu Asp Leu Asp Ala Glu Gly Gln Ser Gln Asp Ser Thr Val Pro Leu 
                805                 810                 815     


Cys Arg Ala Glu Leu Asn Thr His Arg Pro Ala Pro Tyr Glu Ile Gln 
            820                 825                 830         


Gln Glu Phe Trp Ser 
        835         


<210>  301
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  302
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  303
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  304
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Glu Ser Pro 
225                 230                 235                 240 


Ser Arg Arg Gln Thr Trp Thr Arg Ser Glu Glu Glu Glu Gly Glu Cys 
                245                 250                 255     


Pro Ala His Glu Glu Ala Arg Arg Thr Met Arg Ser Ser Ala Gly Gln 
            260                 265                 270         


Ala Trp Lys Trp Ala Pro Val His Arg Pro Gln Asp Glu Ser Asp Lys 
        275                 280                 285             


Gly Glu Phe Gly Lys Arg Ala Lys Ser Arg Asp Met Leu Gly 
    290                 295                 300         


<210>  305
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala 
    210                 215                 220                 


Gln Arg Ala Trp Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu 
225                 230                 235                 240 


Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu 
                245                 250                 255     


Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys 
            260                 265                 270         


Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro 
        275                 280                 285             


Val Arg Ser Arg Val Arg Thr Phe Leu Ser 
    290                 295             


<210>  306
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Ala Arg Asp Val Glu Ala Gln 
    210                 215                 220                 


Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu Asp Arg 
225                 230                 235                 240 


Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys Ala Glu 
                245                 250                 255     


Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro Val Arg 
            260                 265                 270         


Ser Arg Val Arg Thr Phe Leu Ser 
        275                 280 


<210>  307
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr 
        35                  40                  45              


Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys 
    50                  55                  60                  


Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser 
                85                  90                  95      


Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            100                 105                 110         


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        115                 120                 125             


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    130                 135                 140                 


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
145                 150                 155                 160 


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                165                 170                 175     


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            180                 185                 190         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        195                 200                 205             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
225                 230                 235                 240 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                245                 250                 255     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly 
            260                 265                 270         


Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp 
    290                 295                 300                 


Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe 
                325                 330                 335     


Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu 
            340                 345                 350         


Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr 
        355                 360                 365             


Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg 
    370                 375                 380                 


Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn 
385                 390                 395                 400 


Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala 
                405                 410                 415     


Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His 
            420                 425                 430         


Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile 
        435                 440                 445             


Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys 
    450                 455                 460                 


Arg Tyr Gly 
465         


<210>  308
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Gln Gln Ile Pro Gln Glu Lys Ser Ile Asn Asp Tyr Leu Glu Lys 
1               5                   10                  15      


Phe Tyr Gln Leu Pro Ser Asn Gln Tyr Gln Ser Thr Arg Lys Asn Gly 
            20                  25                  30          


Thr Asn Val Ile Val Glu Lys Leu Lys Glu Met Gln Arg Phe Phe Gly 
        35                  40                  45              


Leu Asn Val Thr Gly Lys Pro Asn Glu Glu Thr Leu Asp Met Met Lys 
    50                  55                  60                  


Lys Pro Arg Cys Gly Val Pro Asp Ser Gly Gly Phe Met Leu Thr Pro 
65                  70                  75                  80  


Gly Asn Pro Lys Trp Glu Arg Thr Asn Leu Thr Tyr Arg Ile Arg Asn 
                85                  90                  95      


Tyr Thr Pro Gln Leu Ser Glu Ala Glu Val Glu Arg Ala Ile Lys Asp 
            100                 105                 110         


Ala Phe Glu Leu Trp Ser Val Ala Ser Pro Leu Ile Phe Thr Arg Ile 
        115                 120                 125             


Ser Gln Gly Glu Ala Asp Ile Asn Ile Ala Phe Tyr Gln Arg Asp His 
    130                 135                 140                 


Gly Asp Asn Ser Pro Phe Asp Gly Pro Asn Gly Ile Leu Ala His Ala 
145                 150                 155                 160 


Phe Gln Pro Gly Gln Gly Ile Gly Gly Asp Ala His Phe Asp Ala Glu 
                165                 170                 175     


Glu Thr Trp Thr Asn Thr Ser Ala Asn Tyr Asn Leu Phe Leu Val Ala 
            180                 185                 190         


Ala His Glu Phe Gly His Ser Leu Gly Leu Ala His Ser Ser Asp Pro 
        195                 200                 205             


Gly Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr Ser Asn Tyr 
    210                 215                 220                 


Ser Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Leu 
225                 230                 235                 240 


Ser Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro Lys Pro Cys 
                245                 250                 255     


Asp Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile 
            260                 265                 270         


Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg His Pro Gln Leu Gln 
        275                 280                 285             


Arg Val Glu Met Asn Phe Ile Ser Leu Phe Trp Pro Ser Leu Pro Thr 
    290                 295                 300                 


Gly Ile Gln Ala Ala Tyr Glu Asp Phe Asp Arg Asp Leu Ile Phe Leu 
305                 310                 315                 320 


Phe Lys Gly Asn Gln Tyr Trp Ala Leu Ser Gly Tyr Asp Ile Leu Gln 
                325                 330                 335     


Gly Tyr Pro Lys Asp Ile Ser Asn Tyr Gly Phe Pro Ser Ser Val Gln 
            340                 345                 350         


Ala Ile Asp Ala Ala Val Phe Tyr Arg Ser Lys Thr Tyr Phe Phe Val 
        355                 360                 365             


Asn Asp Gln Phe Trp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro 
    370                 375                 380                 


Gly Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile Glu Ser Lys 
385                 390                 395                 400 


Val Asp Ala Val Phe Gln Gln Glu His Phe Phe His Val Phe Ser Gly 
                405                 410                 415     


Pro Arg Tyr Tyr Ala Phe Asp Leu Ile Ala Gln Arg Val Thr Arg Val 
            420                 425                 430         


Ala Arg Gly Asn Lys Trp Leu Asn Cys Arg Tyr Gly 
        435                 440                 


<210>  309
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Met Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  310
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  311
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  312
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  313
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  314
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 
                85                  90                  95      


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
            100                 105                 110         


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
        115                 120                 125             


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
    130                 135                 140                 


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
145                 150                 155                 160 


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
                165                 170                 175     


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
            180                 185                 190         


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200             


<210>  315
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 
65                  70                  75                  80  


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                85                  90                  95      


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            100                 105                 110         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        115                 120                 125             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    130                 135                 140                 


Ala Thr Ser Ala Asn Leu 
145                 150 


<210>  316
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                85                  90                  95      


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            100                 105                 110         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        115                 120                 125             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155                 


<210>  317
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 
                85                  90                  95      


Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 
            100                 105                 110         


Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 
        115                 120                 125             


Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 
    130                 135                 140                 


Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
145                 150                 155             


<210>  318
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 
                165                 170                 175     


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
            180                 185                 190         


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
        195                 200                 205             


Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 
    210                 215                 220                 


Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 
225                 230                 235                 240 


Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 
                245                 250                 255     


Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 
            260                 265                 270         


Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 
        275                 280                 285             


Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 
    290                 295                 300                 


Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 
305                 310                 315                 320 


Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
                325                 330                 335     


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            340                 345                 350         


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 
        355                 360                 365             


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
    370                 375                 380                 


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
385                 390                 395                 400 


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
                405                 410                 415     


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
            420                 425                 430         


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
        435                 440                 445             


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
    450                 455                 460                 


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
465                 470                 475 


<210>  319
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 
    50                  55                  60                  


Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 
65                  70                  75                  80  


Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 
                85                  90                  95      


Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 
            100                 105                 110         


Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 
        115                 120                 125             


Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
    130                 135                 140                 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 
                165                 170                 175     


Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 
            180                 185                 190         


Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
        195                 200                 205             


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
    210                 215                 220                 


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
225                 230                 235                 240 


Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 
                245                 250                 255     


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
            260                 265                 270         


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
        275                 280                 285             


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
    290                 295                 300                 


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
305                 310                 315                 320 


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
                325                 330                 335     


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
            340                 345                 350         


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
        355                 360                 365             


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    370                 375                 380                 


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
385                 390                 395                 400 


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
                405                 410                 415     


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
            420                 425                 430         


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
        435                 440                 445             


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
    450                 455                 460                 


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
465                 470                 475                 480 


Ser Ala Asn Leu 
                


<210>  320
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 
            100                 105                 110         


Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 
        115                 120                 125             


Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 
    130                 135                 140                 


Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 
145                 150                 155                 160 


Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 
                165                 170                 175     


Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 
            180                 185                 190         


Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 
        195                 200                 205             


Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 
    210                 215                 220                 


Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 
225                 230                 235                 240 


Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 
                245                 250                 255     


Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 
            260                 265                 270         


Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        275                 280         


<210>  321
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Trp Gly Trp Gly Ala Arg Leu Gly His Arg 
145                 150                 155                 160 


Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His Cys Leu Ser 
                165                 170                 175     


His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala 
            180                 185                 190         


Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro 
        195                 200                 205             


His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
    210                 215                 


<210>  322
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr 
    50                  55                  60                  


Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly 
65                  70                  75                  80  


Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
                85                  90                  95      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            100                 105                 110         


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        115                 120                 125             


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 
    130                 135                 140                 


Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 
145                 150                 155                 160 


Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
                165                 170                 175     


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            180                 185                 190         


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        195                 200                 205             


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    210                 215                 220                 


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235             


<210>  323
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 
            20                  25                  30          


Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe 
        35                  40                  45              


Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln 
    50                  55                  60                  


Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu 
65                  70                  75                  80  


Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu 
                85                  90                  95      


Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 
            100                 105                 110         


Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu 
        115                 120                 125             


Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala 
    130                 135                 140                 


Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro 
145                 150                 155                 160 


Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr 
                165                 170                 175     


His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu 
            180                 185                 190         


Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro 
        195                 200                 205             


Ala Val Ala Ala Thr Ser Ala Asn Leu 
    210                 215         


<210>  324
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 
    50                  55                  60                  


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
65                  70                  75                  80  


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
                85                  90                  95      


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
            100                 105                 110         


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
        115                 120                 125             


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
    130                 135                 140                 


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
145                 150                 155                 160 


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
                165                 170                 175     


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
            180                 185                 190         


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
        195                 200                 205             


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
    210                 215                 220                 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
225                 230                 235                 240 


Leu 
    


<210>  325
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 
65                  70                  75                  80  


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
                85                  90                  95      


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
            100                 105                 110         


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
        115                 120                 125             


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
    130                 135                 140                 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
145                 150                 155                 160 


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                165                 170                 175     


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            180                 185                 190         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        195                 200                 205             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    210                 215                 220                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235                 


<210>  326
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 
145                 150                 155                 160 


Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 
                165                 170                 175     


Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 
            180                 185                 190         


Trp Ala Leu Cys Ala Pro 
        195             


<210>  327
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 
65                  70                  75                  80  


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
                85                  90                  95      


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
            100                 105                 110         


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu 
225                 230 


<210>  328
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 
                85                  90                  95      


Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 
            100                 105                 110         


Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 
        115                 120                 125             


Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 
    130                 135                 140                 


Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 
145                 150                 155                 160 


Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 
                165                 170                 175     


Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
            180                 185                 


<210>  329
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Phe 
65                  70                  75                  80  


Cys Arg Phe Ile Asn Lys Gly Val Phe Trp Ala Ser Pro Ile Leu Ser 
                85                  90                  95      


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
        115                 120                 125             


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
    130                 135                 140                 


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
145                 150                 155                 160 


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
                165                 170                 175     


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
            180                 185                 190         


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
        195                 200                 205             


Ser Ala Asn Leu 
    210         


<210>  330
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn 
            100                 105                 110         


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
        115                 120                 125             


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
    130                 135                 140                 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
145                 150                 155                 160 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
                165                 170                 175     


Leu 
    


<210>  331
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  332
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Arg Gly Ala Pro Gly Asn Cys Val Gly Ala Glu Gln Ala Leu Ala 
1               5                   10                  15      


Arg Arg Lys Arg Ala Gln Thr Val Ala Ile Arg Gly His Pro Arg Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Asp Thr Arg Ala Glu Ser Pro Pro Asp Pro Leu 
        35                  40                  45              


Gln Ser Ala Gly Asp Asp Glu Asp Asp Glu Glu Glu Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser Ser Asn Thr 
65                  70                  75                  80  


Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys Asn Ala Ala 
                85                  90                  95      


Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu Lys Arg Cys 
            100                 105                 110         


Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser Pro Tyr Val 
        115                 120                 125             


Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser Glu Ala Ser 
    130                 135                 140                 


Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys Ser Leu Ser 
145                 150                 155                 160 


Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg Asn His Asn 
                165                 170                 175     


Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser Phe Leu Thr 
            180                 185                 190         


Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys Ala Ala Lys 
        195                 200                 205             


Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser Leu Gln Ala 
    210                 215                 220                 


Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln Ala Arg Gln 
225                 230                 235                 240 


Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
                245                 250             


<210>  333
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Arg Gly Ala Pro Gly Asn Cys Val Gly Ala Glu Gln Ala Leu Ala 
1               5                   10                  15      


Arg Arg Lys Arg Ala Gln Thr Val Ala Ile Arg Gly His Pro Arg Pro 
            20                  25                  30          


Pro Gly Pro Pro Gly Asp Thr Arg Ala Glu Ser Pro Pro Asp Pro Leu 
        35                  40                  45              


Gln Ser Ala Gly Val Leu Glu Val Gly Ala Gly Pro Arg Leu Pro Arg 
    50                  55                  60                  


Pro Pro Arg Glu Gly Ser Thr Pro Gly Ile Lys Thr Asn Gly Ala Glu 
65                  70                  75                  80  


Arg Ser Pro Gln Ser Pro Ala Gly Arg Arg Ala Asp Ala Glu Leu Leu 
                85                  90                  95      


His Val His His Ala Gly His Asp Leu Gln Glu Pro Arg Pro Arg Val 
            100                 105                 110         


<210>  334
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  335
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Asp Asp Pro Asp Cys Asp Ser Thr Trp Glu Glu Asp Glu Glu Asp 
1               5                   10                  15      


Ala Glu Asp Ala Glu Asp Glu Asp Cys Glu Asp Gly Glu Ala Ala Gly 
            20                  25                  30          


Ala Arg Asp Ala Asp Ala Gly Asp Glu Asp Glu Glu Ser Glu Glu Pro 
        35                  40                  45              


Arg Ala Ala Arg Pro Ser Ser Phe Gln Ser Arg Met Thr Gly Ser Arg 
    50                  55                  60                  


Asn Trp Arg Ala Thr Arg Asp Met Cys Arg Tyr Arg His Asn Tyr Pro 
65                  70                  75                  80  


Asp Leu Val Glu Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe 
                85                  90                  95      


Tyr Arg Asn Glu Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp 
            100                 105                 110         


Ile Leu Gln Asn Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His 
        115                 120                 125             


Ser Tyr Ile Gln Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp 
    130                 135                 140                 


His Ala Lys Pro Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser 
145                 150                 155                 160 


Gln Glu Ile Gln Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly 
                165                 170                 175     


Phe Tyr Gly Ile Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg 
            180                 185                 190         


Ala Gln Asn Tyr Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His 
        195                 200                 205             


Asn Asn Leu Arg Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly 
    210                 215                 220                 


Leu Glu His Phe Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr 
225                 230                 235                 240 


Leu Val Arg Arg Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr 
                245                 250                 255     


Phe Met Phe Ala Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His 
            260                 265                 270         


Phe Ala Trp Glu His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro 
        275                 280                 285             


Gln Asp Lys Leu Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu 
    290                 295                 300                 


Glu Gly Ser Arg Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp 
305                 310                 315                 320 


His Glu Ala Ser Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys 
                325                 330                 335     


Gly Gly Gly Arg Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro 
            340                 345                 350         


Gln Asp Ala Gly Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly 
        355                 360                 365             


His Gly Glu Asp Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys 
    370                 375                 380                 


Arg Lys Leu Glu Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly 
385                 390                 395                 400 


Pro Gln Ser Ala Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly 
                405                 410                 415     


Cys Ala Leu Ser Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly 
            420                 425                 430         


Gly Gln Asp Pro Gly Glu Ala Val Gln Pro Cys Arg Gln Pro Leu Gly 
        435                 440                 445             


Ala Arg Val Ala Asp Lys Val Arg Lys Arg Arg Lys Val Asp Glu Gly 
    450                 455                 460                 


Ala Gly Asp Ser Ala Ala Val Ala Ser Gly Gly Ala Gln Thr Leu Ala 
465                 470                 475                 480 


Leu Ala Gly Ser Pro Ala Pro Ser Gly His Pro Lys Ala Gly His Ser 
                485                 490                 495     


Glu Asn Gly Val Glu Glu Asp Thr Glu Gly Arg Thr Gly Pro Lys Glu 
            500                 505                 510         


Gly Thr Pro Gly Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly 
        515                 520                 525             


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
    530                 535                 540                 


Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu 
545                 550                 555                 560 


Thr Pro Gly Pro Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu 
                565                 570                 575     


Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp 
            580                 585                 590         


Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly 
        595                 600                 605             


Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro 
    610                 615                 620                 


Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu 
625                 630                 635                 640 


Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Lys 
                645                 650                 655     


Ala Gly Glu Ala Ala Glu Leu Gln Asp Ala Glu Val Glu Ser Ser Ala 
            660                 665                 670         


Lys Ser Gly Lys Pro 
        675         


<210>  336
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Ser Ala Arg Val Arg Ser Arg Ser Arg Gly Arg Gly Asp Gly Gln 
1               5                   10                  15      


Glu Ala Pro Asp Val Val Ala Phe Val Ala Pro Gly Glu Ser Gln Gln 
            20                  25                  30          


Glu Glu Pro Pro Thr Asp Asn Gln Asp Ile Glu Pro Gly Gln Glu Arg 
        35                  40                  45              


Glu Gly Thr Pro Pro Ile Glu Glu Arg Lys Val Glu Gly Asp Cys Gln 
    50                  55                  60                  


Glu Met Asp Leu Glu Lys Thr Arg Ser Glu Arg Gly Asp Gly Ser Asp 
65                  70                  75                  80  


Val Lys Glu Lys Thr Pro Pro Asn Pro Lys His Ala Lys Thr Lys Glu 
                85                  90                  95      


Ala Gly Asp Gly Gln Pro 
            100         


<210>  337
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Gly Lys Arg Trp Arg Leu Gly Arg Arg Thr Cys Trp Val 
        195                 200                 205             


Thr Trp Arg Ala Ser Ala Ser 
    210                 215 


<210>  338
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Val Thr Thr Pro Asp 
            100                 105                 110         


Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met Phe 
        115                 120                 125             


Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp Arg 
    130                 135                 140                 


Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser Lys 
145                 150                 155                 160 


Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu Ala 
                165                 170                 175     


Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu Ser 
            180                 185                 190         


Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp Ser 
        195                 200                 205             


Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr Thr 
    210                 215                 220                 


Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg Thr 
225                 230                 235                 240 


His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala Lys 
                245                 250                 255     


Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala Arg 
            260                 265                 270         


Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His Leu 
        275                 280                 285             


Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr Tyr 
    290                 295                 300                 


Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala Val 
305                 310                 315                 320 


Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro Ser 
                325                 330                 335     


Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser Ala 
            340                 345                 350         


Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp Ser 
        355                 360                 365             


Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile Gly 
    370                 375                 380                 


Asn Gly Leu Ser Pro Gln Val Met Gly Leu Leu Thr Asn His Gly Gly 
385                 390                 395                 400 


Val Pro His Gln Pro Gln Thr Asp Tyr Ala Leu Ser Pro Leu Thr Gly 
                405                 410                 415     


Gly Leu Glu Pro Thr Thr Thr Val Ser Ala Ser Cys Ser Gln Arg Leu 
            420                 425                 430         


Asp His Met Lys Ser Leu Asp Ser Leu Pro Thr Ser Gln Ser Tyr Cys 
        435                 440                 445             


Pro Pro Thr Tyr Ser Thr Thr Gly Tyr Ser Met Asp Pro Val Thr Gly 
    450                 455                 460                 


Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser Ala Phe His Tyr Leu Lys Pro 
465                 470                 475                 480 


Asp Ile Ala 
            


<210>  339
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Gly Lys Ala Leu Val Ser Gly Val Ser Ser His 
        195                 200                 205     


<210>  340
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Met Gly Leu Leu Thr Asn His Gly 
385                 390                 395                 400 


Gly Val Pro His Gln Pro Gln Thr Asp Tyr Ala Leu Ser Pro Leu Thr 
                405                 410                 415     


Gly Gly Leu Glu Pro Thr Thr Thr Val Ser Ala Ser Cys Ser Gln Arg 
            420                 425                 430         


Leu Asp His Met Lys Ser Leu Asp Ser Leu Pro Thr Ser Gln Ser Tyr 
        435                 440                 445             


Cys Pro Pro Thr Tyr Ser Thr Thr Gly Tyr Ser Met Asp Pro Val Thr 
    450                 455                 460                 


Gly Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser Lys Pro Trp Thr Phe 
465                 470                 475                 


<210>  341
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Met Gly Leu Leu Thr Asn His Gly 
385                 390                 395                 400 


Gly Val Pro His Gln Pro Gln Thr Asp Tyr Ala Leu Ser Pro Leu Thr 
                405                 410                 415     


Gly Gly Leu Glu Pro Thr Thr Thr Val Ser Ala Ser Cys Ser Gln Arg 
            420                 425                 430         


Leu Asp His Met Lys Ser Leu Asp Ser Leu Pro Thr Ser Gln Ser Tyr 
        435                 440                 445             


Cys Pro Pro Thr Tyr Ser Thr Thr Gly Tyr Ser Met Asp Pro Val Thr 
    450                 455                 460                 


Gly Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser Ala Phe His Tyr Leu Lys 
465                 470                 475                 480 


Pro Asp Ile Ala 
                


<210>  342
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Met Gly Leu Leu Thr Asn His Gly 
385                 390                 395                 400 


Gly Val Pro His Gln Pro Gln Thr Asp Tyr Ala Leu Ser Pro Leu Thr 
                405                 410                 415     


Gly Gly Leu Glu Pro Thr Thr Thr Val Ser Ala Ser Cys Ser Gln Arg 
            420                 425                 430         


Leu Asp His Met Lys Ser Leu Asp Ser Leu Pro Thr Ser Gln Ser Tyr 
        435                 440                 445             


Cys Pro Pro Thr Tyr Ser Thr Thr Gly Tyr Ser Met Asp Pro Val Thr 
    450                 455                 460                 


Gly Tyr Gln Tyr Gly Gln Tyr Gly Gln Ser Ala Phe His Tyr Leu Lys 
465                 470                 475                 480 


Pro Asp Ile Ala Trp Phe Gln Ile Leu Leu Asn Thr Phe Asp Lys Ser 
                485                 490                 495     


Ser Gly Glu Glu Glu Asp Leu Glu Gln 
            500                 505 


<210>  343
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Pro Phe Ile Ile Ser Ser Gln Ile 
385                 390                 395                 400 


Ser Leu Gly Phe Lys Ser Phe 
                405         


<210>  344
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Thr Thr Leu Ala Gly Ala Val Pro Arg Met Met Arg Pro Gly Pro 
1               5                   10                  15      


Gly Gln Asn Tyr Pro Arg Ser Gly Phe Pro Leu Glu Val Ser Thr Pro 
            20                  25                  30          


Leu Gly Gln Gly Arg Val Asn Gln Leu Gly Gly Val Phe Ile Asn Gly 
        35                  40                  45              


Arg Pro Leu Pro Asn His Ile Arg His Lys Ile Val Glu Met Ala His 
    50                  55                  60                  


His Gly Ile Arg Pro Cys Val Ile Ser Arg Gln Leu Arg Val Ser His 
65                  70                  75                  80  


Gly Cys Val Ser Lys Ile Leu Cys Arg Tyr Gln Glu Thr Gly Ser Ile 
                85                  90                  95      


Arg Pro Gly Ala Ile Gly Gly Ser Lys Pro Lys Gln Val Thr Thr Pro 
            100                 105                 110         


Asp Val Glu Lys Lys Ile Glu Glu Tyr Lys Arg Glu Asn Pro Gly Met 
        115                 120                 125             


Phe Ser Trp Glu Ile Arg Asp Lys Leu Leu Lys Asp Ala Val Cys Asp 
    130                 135                 140                 


Arg Asn Thr Val Pro Ser Val Ser Ser Ile Ser Arg Ile Leu Arg Ser 
145                 150                 155                 160 


Lys Phe Gly Lys Gly Glu Glu Glu Glu Ala Asp Leu Glu Arg Lys Glu 
                165                 170                 175     


Ala Glu Glu Ser Glu Lys Lys Ala Lys His Ser Ile Asp Gly Ile Leu 
            180                 185                 190         


Ser Glu Arg Ala Ser Ala Pro Gln Ser Asp Glu Gly Ser Asp Ile Asp 
        195                 200                 205             


Ser Glu Pro Asp Leu Pro Leu Lys Arg Lys Gln Arg Arg Ser Arg Thr 
    210                 215                 220                 


Thr Phe Thr Ala Glu Gln Leu Glu Glu Leu Glu Arg Ala Phe Glu Arg 
225                 230                 235                 240 


Thr His Tyr Pro Asp Ile Tyr Thr Arg Glu Glu Leu Ala Gln Arg Ala 
                245                 250                 255     


Lys Leu Thr Glu Ala Arg Val Gln Val Trp Phe Ser Asn Arg Arg Ala 
            260                 265                 270         


Arg Trp Arg Lys Gln Ala Gly Ala Asn Gln Leu Met Ala Phe Asn His 
        275                 280                 285             


Leu Ile Pro Gly Gly Phe Pro Pro Thr Ala Met Pro Thr Leu Pro Thr 
    290                 295                 300                 


Tyr Gln Leu Ser Glu Thr Ser Tyr Gln Pro Thr Ser Ile Pro Gln Ala 
305                 310                 315                 320 


Val Ser Asp Pro Ser Ser Thr Val His Arg Pro Gln Pro Leu Pro Pro 
                325                 330                 335     


Ser Thr Val His Gln Ser Thr Ile Pro Ser Asn Pro Asp Ser Ser Ser 
            340                 345                 350         


Ala Tyr Cys Leu Pro Ser Thr Arg His Gly Phe Ser Ser Tyr Thr Asp 
        355                 360                 365             


Ser Phe Val Pro Pro Ser Gly Pro Ser Asn Pro Met Asn Pro Thr Ile 
    370                 375                 380                 


Gly Asn Gly Leu Ser Pro Gln Val Pro Phe Ile Ile Ser Ser Gln Ile 
385                 390                 395                 400 


Ser Arg Lys 
            


<210>  345
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly 
            260                 265                 270         


Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp 
        275                 280                 285             


Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly 
    290                 295                 300                 


Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro His Val Pro 
305                 310                 315                 320 


Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr Leu Thr Gly Met Val 
                325                 330                 335     


Pro Gly Ser Glu Phe Ser Gly Ser Pro Tyr Ser His Pro Gln Tyr Ser 
            340                 345                 350         


Ser Tyr Asn Asp Ser Trp Arg Phe Pro Asn Pro Gly Leu Leu Gly Ser 
        355                 360                 365             


Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala Pro Pro Ala Ala 
    370                 375                 380                 


Ala Thr Ala Tyr Asp Arg His 
385                 390     


<210>  346
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly 
            260                 265                 270         


Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp 
        275                 280                 285             


Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly 
    290                 295                 300                 


Ser Glu Phe Ser Gly Ser Pro Tyr Ser His Pro Gln Tyr Ser Ser Tyr 
305                 310                 315                 320 


Asn Asp Ser Trp Arg Phe Pro Asn Pro Gly Leu Leu Gly Ser Pro Tyr 
                325                 330                 335     


Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala Pro Pro Ala Ala Ala Thr 
            340                 345                 350         


Ala Tyr Asp Arg His 
        355         


<210>  347
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly 
            260                 265                 270         


Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp 
        275                 280                 285             


Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly 
    290                 295                 300                 


Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro His Val Pro 
305                 310                 315                 320 


Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr Leu Thr Gly Met Val 
                325                 330                 335     


Pro Gly Ser Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala Pro 
            340                 345                 350         


Pro Ala Ala Ala Thr Ala Tyr Asp Arg His 
        355                 360         


<210>  348
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Gly Val Ser Phe Pro Gly Val Pro Thr Ala Thr Leu 
            260                 265                 270         


Ser Ile Pro Arg Thr Thr Thr Pro Gly Gly Ser Pro Thr Arg Gly Cys 
        275                 280                 285             


Leu Ala Pro Pro Thr Ile Ile Ala Leu Pro Pro Glu Glu Pro Pro His 
    290                 295                 300                 


Leu Gln Pro Pro Leu Pro Met Thr Val Thr Asp Pro Trp Ser Gln Ala 
305                 310                 315                 320 


Gly Thr Lys His 
                


<210>  349
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Ala Pro Pro Thr Ile Ile Ala Leu Pro Pro Glu Glu 
            260                 265                 270         


Pro Pro His Leu Gln Pro Pro Leu Pro Met Thr Val Thr Asp Pro Trp 
        275                 280                 285             


Ser Gln Ala Gly Thr Lys His 
    290                 295 


<210>  350
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys 
1               5                   10                  15      


Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg 
            20                  25                  30          


Thr Lys Val Gln Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His 
        35                  40                  45              


Ser Ile Val Ser Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr 
    50                  55                  60                  


Asp Ser Ala Gly Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr 
65                  70                  75                  80  


Ser Pro Ser Ala Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln 
                85                  90                  95      


Glu Ser Pro Val Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu 
            100                 105                 110         


Arg Lys Gln Met Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val 
        115                 120                 125             


Leu Asp Arg Val Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr 
    130                 135                 140                 


Thr Glu Pro Ile Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala 
145                 150                 155                 160 


Ser Leu Ala Gly Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro 
                165                 170                 175     


Thr Pro Ala Asp Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro 
            180                 185                 190         


Ile Val Thr Gly Ser Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala 
        195                 200                 205             


Ala Pro Pro Ala Ala Ala Thr Ala Tyr Asp Arg His 
    210                 215                 220 


<210>  351
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser 
145                 150                 155                 160 


Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly 
                165                 170                 175     


Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala 
            180                 185                 190         


Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val 
        195                 200                 205             


Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met 
    210                 215                 220                 


Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val 
225                 230                 235                 240 


Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile 
                245                 250                 255     


Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly 
            260                 265                 270         


Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp 
        275                 280                 285             


Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly 
    290                 295                 300                 


Ser Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala Pro Pro Ala 
305                 310                 315                 320 


Ala Ala Thr Ala Tyr Asp Arg His 
                325             


<210>  352
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Pro Val Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe 
                165                 170                 175     


Leu Arg Lys Gln Met Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu 
            180                 185                 190         


Val Leu Asp Arg Val Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr 
        195                 200                 205             


Thr Thr Glu Pro Ile Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met 
    210                 215                 220                 


Ala Ser Leu Ala Gly Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser 
225                 230                 235                 240 


Pro Thr Pro Ala Asp Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr 
                245                 250                 255     


Pro Ile Val Thr Gly Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr 
            260                 265                 270         


Pro Pro His Val Pro Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr 
        275                 280                 285             


Leu Thr Gly Met Val Pro Gly Ser Pro Tyr Tyr Tyr Ser Ala Ala Ala 
    290                 295                 300                 


Arg Gly Ala Ala Pro Pro Ala Ala Ala Thr Ala Tyr Asp Arg His 
305                 310                 315                 


<210>  353
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro 
65                  70                  75                  80  


Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val 
                85                  90                  95      


Glu Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp 
            100                 105                 110         


Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys Asp Asn Asp Thr 
        115                 120                 125             


Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln 
    130                 135                 140                 


Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Pro Val Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe 
                165                 170                 175     


Leu Arg Lys Gln Met Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu 
            180                 185                 190         


Val Leu Asp Arg Val Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr 
        195                 200                 205             


Thr Thr Glu Pro Ile Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met 
    210                 215                 220                 


Ala Ser Leu Ala Gly Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser 
225                 230                 235                 240 


Pro Thr Pro Ala Asp Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr 
                245                 250                 255     


Pro Ile Val Thr Gly Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr 
            260                 265                 270         


Pro Pro His Val Pro Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr 
        275                 280                 285             


Leu Thr Gly Met Val Pro Gly Ser Glu Phe Ser Gly Ser Pro Tyr Ser 
    290                 295                 300                 


His Pro Gln Tyr Ser Ser Tyr Asn Asp Ser Trp Arg Phe Pro Asn Pro 
305                 310                 315                 320 


Gly Leu Leu Gly Ser Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala 
                325                 330                 335     


Ala Pro Pro Ala Ala Ala Thr Ala Tyr Asp Arg His 
            340                 345             


<210>  354
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Asp Leu Glu Lys Asn Tyr Pro Thr Pro Arg Thr Ser Arg Thr Gly 
1               5                   10                  15      


His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro 
            20                  25                  30          


Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly 
        35                  40                  45              


Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys 
    50                  55                  60                  


Val Ser Lys Ile Leu Gly Arg Ile Ile Arg Thr Lys Val Gln Gln Pro 
65                  70                  75                  80  


Pro Asn Gln Pro Val Pro Ala Ser Ser His Ser Ile Val Ser Thr Gly 
                85                  90                  95      


Ser Val Thr Gln Val Ser Ser Val Ser Thr Asp Ser Ala Gly Ser Ser 
            100                 105                 110         


Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr Ser Pro Ser Ala Asp Thr 
        115                 120                 125             


Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln Glu Ser Pro Val Pro Asn 
    130                 135                 140                 


Gly His Ser Leu Pro Gly Arg Asp Phe Leu Arg Lys Gln Met Arg Gly 
145                 150                 155                 160 


Asp Leu Phe Thr Gln Gln Gln Leu Glu Val Leu Asp Arg Val Phe Glu 
                165                 170                 175     


Arg Gln His Tyr Ser Asp Ile Phe Thr Thr Thr Glu Pro Ile Lys Pro 
            180                 185                 190         


Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala Ser Leu Ala Gly Gly Leu 
        195                 200                 205             


Asp Asp Met Lys Ala Asn Leu Ala Ser Pro Thr Pro Ala Asp Ile Gly 
    210                 215                 220                 


Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro Ile Val Thr Gly Ser Glu 
225                 230                 235                 240 


Phe Ser Gly Ser Pro Tyr Ser His Pro Gln Tyr Ser Ser Tyr Asn Asp 
                245                 250                 255     


Ser Trp Arg Phe Pro Asn Pro Gly Leu Leu Gly Ser Pro Tyr Tyr Tyr 
            260                 265                 270         


Ser Ala Ala Ala Arg Gly Ala Ala Pro Pro Ala Ala Ala Thr Ala Tyr 
        275                 280                 285             


Asp Arg His 
    290     


<210>  355
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ala Glu Arg Val Cys 
1               5                   10                  15      


Asp Asn Asp Thr Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg 
            20                  25                  30          


Thr Lys Val Gln Gln Pro Pro Asn Gln Pro Val Pro Ala Ser Ser His 
        35                  40                  45              


Ser Ile Val Ser Thr Gly Ser Val Thr Gln Val Ser Ser Val Ser Thr 
    50                  55                  60                  


Asp Ser Ala Gly Ser Ser Tyr Ser Ile Ser Gly Ile Leu Gly Ile Thr 
65                  70                  75                  80  


Ser Pro Ser Ala Asp Thr Asn Lys Arg Lys Arg Asp Glu Gly Ile Gln 
                85                  90                  95      


Glu Ser Pro Val Pro Asn Gly His Ser Leu Pro Gly Arg Asp Phe Leu 
            100                 105                 110         


Arg Lys Gln Met Arg Gly Asp Leu Phe Thr Gln Gln Gln Leu Glu Val 
        115                 120                 125             


Leu Asp Arg Val Phe Glu Arg Gln His Tyr Ser Asp Ile Phe Thr Thr 
    130                 135                 140                 


Thr Glu Pro Ile Lys Pro Glu Gln Thr Thr Glu Tyr Ser Ala Met Ala 
145                 150                 155                 160 


Ser Leu Ala Gly Gly Leu Asp Asp Met Lys Ala Asn Leu Ala Ser Pro 
                165                 170                 175     


Thr Pro Ala Asp Ile Gly Ser Ser Val Pro Gly Pro Gln Ser Tyr Pro 
            180                 185                 190         


Ile Val Thr Gly Arg Asp Leu Ala Ser Thr Thr Leu Pro Gly Tyr Pro 
        195                 200                 205             


Pro His Val Pro Pro Ala Gly Gln Gly Ser Tyr Ser Ala Pro Thr Leu 
    210                 215                 220                 


Thr Gly Met Val Pro Gly Ser Glu Phe Ser Gly Ser Pro Tyr Ser His 
225                 230                 235                 240 


Pro Gln Tyr Ser Ser Tyr Asn Asp Ser Trp Arg Phe Pro Asn Pro Gly 
                245                 250                 255     


Leu Leu Gly Ser Pro Tyr Tyr Tyr Ser Ala Ala Ala Arg Gly Ala Ala 
            260                 265                 270         


Pro Pro Ala Ala Ala Thr Ala Tyr Asp Arg His 
        275                 280             


<210>  356
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  357
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
1               5                   10                  15      


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
            20                  25                  30          


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
        35                  40                  45              


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
    50                  55                  60                  


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
65                  70                  75                  80  


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
                85                  90                  95      


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
            100                 105                 110         


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
        115                 120                 125             


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
    130                 135                 140                 


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
145                 150                 155                 160 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
                165                 170                 175     


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
            180                 185                 190         


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
        195                 200                 205             


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
225                 230                 235                 240 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
                245                 250                 255     


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
            260                 265                 270         


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
        275                 280                 285             


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
    290                 295                 300                 


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
305                 310                 315                 320 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
                325                 330                 335     


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
            340                 345                 350         


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
        355                 360                 365             


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
    370                 375                 380                 


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
385                 390                 395                 400 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
                405                 410                 415     


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
            420                 425                 430         


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
        435                 440                 445             


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
    450                 455                 460                 


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
465                 470                 475                 480 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
                485                 490                 495     


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
            500                 505                 510         


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
        515                 520                 525             


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
    530                 535                 540                 


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
545                 550                 555                 560 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
                565                 570                 575     


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
            580                 585                 590         


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
        595                 600                 605             


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
    610                 615                 620                 


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
625                 630                 635                 640 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
                645                 650                 655     


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
            660                 665                 670         


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
        675                 680                 685             


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
    690                 695                 700                 


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
705                 710                 715                 720 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
                725                 730                 735     


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
            740                 745                 750         


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
        755                 760                 765             


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
    770                 775                 780                 


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
785                 790                 795                 800 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
                805                 810                 815     


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
            820                 825                 830         


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
        835                 840                 845             


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
    850                 855                 860                 


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
865                 870                 875                 880 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
                885                 890                 895     


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
            900                 905                 910         


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
        915                 920                 925             


Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu 
    930                 935                 940                 


Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro 
945                 950                 955                 960 


Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly 
                965                 970                 975     


Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser 
            980                 985                 990         


Thr Ile Ser Cys Asp Ser Pro Leu  Glu Pro Gln Asp Glu  Pro Glu Pro 
        995                 1000                 1005             


Glu Pro  Gln Leu Glu Leu Gln  Val Glu Pro Glu Pro  Glu Leu Glu 
    1010                 1015                 1020             


Gln Leu  Pro Asp Ser Gly Cys  Pro Ala Pro Arg Ala  Glu Ala Glu 
    1025                 1030                 1035             


Asp Ser  Phe Leu 
    1040         


<210>  358
<211>  945
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Ile Thr Asn Val Ala Phe Leu Val Ser Leu Arg Thr Glu Ala Thr 
1               5                   10                  15      


Ser Ala Lys Pro Pro Leu Gly Thr Gly Arg Trp Ile Leu Met Pro Thr 
            20                  25                  30          


Met Ser Thr Asp Ser Arg Val Ser Pro Leu Ser Gly Leu Met Leu Ser 
        35                  40                  45              


Arg Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val Val 
    50                  55                  60                  


Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn Glu 
65                  70                  75                  80  


Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg Leu 
                85                  90                  95      


Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile Arg 
            100                 105                 110         


Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr Tyr 
        115                 120                 125             


Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys Ala 
    130                 135                 140                 


Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly Glu 
145                 150                 155                 160 


Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu Gln 
                165                 170                 175     


Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys Asp 
            180                 185                 190         


Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser Thr 
        195                 200                 205             


Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val Arg 
    210                 215                 220                 


Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His Glu 
225                 230                 235                 240 


Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro Val 
                245                 250                 255     


Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln Thr 
            260                 265                 270         


Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp Ser 
        275                 280                 285             


Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr Leu 
    290                 295                 300                 


Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val Thr 
305                 310                 315                 320 


Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg Leu 
                325                 330                 335     


Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn Ala 
            340                 345                 350         


Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
        355                 360                 365             


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
    370                 375                 380                 


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
385                 390                 395                 400 


Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly His 
                405                 410                 415     


Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr Trp 
            420                 425                 430         


Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser Gly 
        435                 440                 445             


Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His Ser 
    450                 455                 460                 


Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala Arg 
465                 470                 475                 480 


Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser His 
                485                 490                 495     


Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys 
            500                 505                 510         


Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp Leu 
        515                 520                 525             


Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His Ser 
    530                 535                 540                 


Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu Pro 
545                 550                 555                 560 


Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser Asp 
                565                 570                 575     


Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val Pro 
            580                 585                 590         


Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser Ser 
        595                 600                 605             


Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu Arg 
    610                 615                 620                 


Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr Met 
625                 630                 635                 640 


Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe Leu 
                645                 650                 655     


Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
            660                 665                 670         


Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala Arg 
        675                 680                 685             


Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe Leu 
    690                 695                 700                 


Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr Thr 
705                 710                 715                 720 


Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe 
                725                 730                 735     


Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln Phe 
            740                 745                 750         


Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His Ala 
        755                 760                 765             


Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys Phe 
    770                 775                 780                 


Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg Leu 
785                 790                 795                 800 


Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu Phe 
                805                 810                 815     


Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu Pro 
            820                 825                 830         


Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu Tyr 
        835                 840                 845             


Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro Leu 
    850                 855                 860                 


Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly Ser 
865                 870                 875                 880 


Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser Thr 
                885                 890                 895     


Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu Pro Glu 
            900                 905                 910         


Pro Gln Leu Glu Leu Gln Val Glu Pro Glu Pro Glu Leu Glu Gln Leu 
        915                 920                 925             


Pro Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp Ser Phe 
    930                 935                 940                 


Leu 
945 


<210>  359
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Lys Val Phe Lys Phe Ile Gly Leu Met Ile Leu Leu Thr Ser Ala 
1               5                   10                  15      


Phe Ser Ala Gly Ser Gly Gln Ser Pro Met Thr Val Leu Cys Ser Ile 
            20                  25                  30          


Asp Trp Phe Met Val Thr Val His Pro Phe Met Leu Asn Asn Asp Val 
        35                  40                  45              


Cys Val His Phe His Glu Leu His Leu Gly Leu Gly Cys Pro Pro Asn 
    50                  55                  60                  


His Val Gln Pro His Ala Tyr Gln Phe Thr Tyr Arg Val Thr Glu Cys 
65                  70                  75                  80  


Gly Ile Arg Ala Lys Ala Val Ser Gln Asp Met Val Ile Tyr Ser Thr 
                85                  90                  95      


Glu Ile His Tyr Ser Ser Lys Gly Thr Pro Ser Lys Phe Val Ile Pro 
            100                 105                 110         


Val Ser Cys Ala Ala Pro Gln Lys Ser Pro Trp Leu Thr Lys Pro Cys 
        115                 120                 125             


Ser Met Arg Val Ala Ser Lys Ser Arg Ala Thr Ala Gln Lys Asp Glu 
    130                 135                 140                 


Lys Cys Tyr Glu Val Phe Ser Leu Ser Gln Ser Ser Gln Arg Pro Asn 
145                 150                 155                 160 


Cys Asp Cys Pro Pro Cys Val Phe Ser Glu Glu Glu His Thr Gln Val 
                165                 170                 175     


Pro Cys His Gln Ala Gly Ala Gln Glu Ala Gln Pro Leu Gln Pro Ser 
            180                 185                 190         


His Phe Leu Asp Ile Ser Glu Asp Trp Ser Leu His Thr Asp Asp Met 
        195                 200                 205             


Ile Gly Ser Met 
    210         


<210>  360
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  361
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
1               5                   10                  15      


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
            20                  25                  30          


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
        35                  40                  45              


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
    50                  55                  60                  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
65                  70                  75                  80  


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
                85                  90                  95      


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
            100                 105                 110         


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
        115                 120                 125             


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
    130                 135                 140                 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
145                 150                 155                 160 


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
                165                 170                 175     


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
            180                 185                 190         


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
        195                 200                 205             


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
    210                 215                 220                 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
225                 230                 235                 240 


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
                245                 250                 255     


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
            260                 265                 270         


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
        275                 280                 285             


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
    290                 295                 300                 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
305                 310                 315                 320 


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
                325                 330                 335     


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
            340                 345                 350         


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
        355                 360                 365             


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
    370                 375                 380                 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
385                 390                 395                 400 


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
                405                 410                 415     


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
            420                 425                 430         


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
        435                 440                 445             


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
    450                 455                 460                 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
465                 470                 475                 480 


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
                485                 490             


<210>  362
<211>  1606
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Ser Glu Asp Ser Arg Gly Asp Ser Arg Ala Glu Ser Ala Lys Asp 
1               5                   10                  15      


Leu Glu Lys Gln Leu Arg Leu Arg Val Cys Val Leu Ser Glu Leu Gln 
            20                  25                  30          


Lys Thr Glu Arg Asp Tyr Val Gly Thr Leu Glu Phe Leu Val Ser Ala 
        35                  40                  45              


Phe Leu His Arg Met Asn Gln Cys Ala Ala Ser Lys Val Asp Lys Asn 
    50                  55                  60                  


Val Thr Glu Glu Thr Val Lys Met Leu Phe Ser Asn Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Ala Val His Lys Glu Phe Leu Lys Val Val Glu Glu Cys Leu His 
                85                  90                  95      


Pro Glu Pro Asn Ala Gln Gln Glu Val Gly Thr Cys Phe Leu His Phe 
            100                 105                 110         


Lys Asp Lys Phe Arg Ile Tyr Asp Glu Tyr Cys Ser Asn His Glu Lys 
        115                 120                 125             


Ala Gln Lys Leu Leu Leu Glu Leu Asn Lys Ile Arg Thr Ile Arg Thr 
    130                 135                 140                 


Phe Leu Leu Asn Cys Met Leu Leu Gly Gly Arg Lys Asn Thr Asp Val 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Leu Val Thr Pro Ile Gln Arg Ile Cys Lys Tyr 
                165                 170                 175     


Pro Leu Ile Leu Lys Glu Leu Leu Lys Arg Thr Pro Arg Lys His Ser 
            180                 185                 190         


Asp Tyr Ala Ala Val Met Glu Ala Leu Gln Ala Met Lys Ala Val Cys 
        195                 200                 205             


Ser Asn Ile Asn Glu Ala Lys Arg Gln Met Glu Lys Leu Glu Val Leu 
    210                 215                 220                 


Glu Glu Trp Gln Ser His Ile Glu Gly Trp Glu Gly Ser Asn Ile Thr 
225                 230                 235                 240 


Asp Thr Cys Thr Glu Met Leu Met Cys Gly Val Leu Leu Lys Ile Ser 
                245                 250                 255     


Ser Gly Asn Ile Gln Glu Arg Val Phe Phe Leu Phe Asp Asn Leu Leu 
            260                 265                 270         


Val Tyr Cys Lys Arg Lys His Arg Arg Leu Lys Asn Ser Lys Ala Ser 
        275                 280                 285             


Thr Asp Gly His Arg Tyr Leu Phe Arg Gly Arg Ile Asn Thr Glu Val 
    290                 295                 300                 


Met Glu Val Glu Asn Val Asp Asp Gly Thr Ala Asp Phe His Ser Ser 
305                 310                 315                 320 


Gly His Ile Val Val Asn Gly Trp Lys Ile His Asn Thr Ala Lys Asn 
                325                 330                 335     


Lys Trp Phe Val Cys Met Ala Lys Thr Pro Glu Glu Lys His Glu Trp 
            340                 345                 350         


Phe Glu Ala Ile Leu Lys Glu Arg Glu Arg Arg Lys Gly Leu Lys Leu 
        355                 360                 365             


Gly Met Glu Gln Asp Thr Trp Val Met Ile Ser Glu Gln Gly Glu Lys 
    370                 375                 380                 


Leu Tyr Lys Met Met Cys Arg Gln Gly Asn Leu Ile Lys Asp Arg Lys 
385                 390                 395                 400 


Arg Lys Leu Thr Thr Phe Pro Lys Cys Phe Leu Gly Ser Glu Phe Val 
                405                 410                 415     


Ser Trp Leu Leu Glu Ile Gly Glu Ile His Arg Pro Glu Glu Gly Val 
            420                 425                 430         


His Leu Gly Gln Ala Leu Leu Glu Asn Gly Ile Ile His His Val Thr 
        435                 440                 445             


Asp Lys His Gln Phe Lys Pro Glu Gln Met Leu Tyr Arg Phe Arg Tyr 
    450                 455                 460                 


Asp Asp Gly Thr Phe Tyr Pro Arg Asn Glu Met Gln Asp Val Ile Ser 
465                 470                 475                 480 


Lys Gly Val Arg Leu Tyr Cys Arg Leu His Ser Leu Phe Thr Pro Val 
                485                 490                 495     


Ile Arg Asp Lys Asp Tyr His Leu Arg Thr Tyr Lys Ser Val Val Met 
            500                 505                 510         


Ala Asn Lys Leu Ile Asp Trp Leu Ile Ala Gln Gly Asp Cys Arg Thr 
        515                 520                 525             


Arg Glu Glu Ala Met Ile Phe Gly Val Gly Leu Cys Asp Asn Gly Phe 
    530                 535                 540                 


Met His His Val Leu Glu Lys Ser Glu Phe Lys Asp Glu Pro Leu Leu 
545                 550                 555                 560 


Phe Arg Phe Phe Ser Asp Glu Glu Met Glu Gly Ser Asn Met Lys His 
                565                 570                 575     


Arg Leu Met Lys His Asp Leu Lys Val Val Glu Asn Val Ile Ala Lys 
            580                 585                 590         


Ser Leu Leu Ile Lys Ser Asn Glu Gly Ser Tyr Gly Phe Gly Leu Glu 
        595                 600                 605             


Asp Lys Asn Lys Val Pro Ile Ile Lys Leu Val Glu Lys Gly Ser Asn 
    610                 615                 620                 


Ala Glu Met Ala Gly Met Glu Val Gly Lys Lys Ile Phe Ala Ile Asn 
625                 630                 635                 640 


Gly Asp Leu Val Phe Met Arg Pro Phe Asn Glu Val Asp Cys Phe Leu 
                645                 650                 655     


Lys Ser Cys Leu Asn Ser Arg Lys Pro Leu Arg Val Leu Val Ser Thr 
            660                 665                 670         


Lys Pro Arg Glu Thr Val Lys Ile Pro Asp Ser Ala Asp Gly Leu Gly 
        675                 680                 685             


Phe Gln Ile Arg Gly Phe Gly Pro Ser Val Val His Ala Val Gly Arg 
    690                 695                 700                 


Gly Thr Val Ala Ala Ala Ala Gly Leu His Pro Gly Gln Cys Ile Ile 
705                 710                 715                 720 


Lys Val Asn Gly Ile Asn Val Ser Lys Glu Thr His Ala Ser Val Ile 
                725                 730                 735     


Ala His Val Thr Ala Cys Arg Lys Tyr Arg Arg Pro Thr Lys Gln Asp 
            740                 745                 750         


Ser Ile Gln Trp Val Tyr Asn Ser Ile Glu Ser Ala Gln Glu Asp Leu 
        755                 760                 765             


Gln Lys Ser His Ser Lys Pro Pro Gly Asp Glu Ala Gly Asp Ala Phe 
    770                 775                 780                 


Asp Cys Lys Val Glu Glu Val Ile Asp Lys Phe Asn Thr Met Ala Ile 
785                 790                 795                 800 


Ile Asp Gly Lys Lys Glu His Val Ser Leu Thr Val Asp Asn Val His 
                805                 810                 815     


Leu Glu Tyr Gly Val Val Tyr Glu Tyr Asp Ser Thr Ala Gly Ile Lys 
            820                 825                 830         


Cys Asn Val Val Glu Lys Met Ile Glu Pro Lys Gly Phe Phe Ser Leu 
        835                 840                 845             


Thr Ala Lys Ile Leu Glu Ala Leu Ala Lys Ser Asp Glu His Phe Val 
    850                 855                 860                 


Gln Asn Cys Thr Ser Leu Asn Ser Leu Asn Glu Val Ile Pro Thr Asp 
865                 870                 875                 880 


Leu Gln Ser Lys Phe Ser Ala Leu Cys Ser Glu Arg Ile Glu His Leu 
                885                 890                 895     


Cys Gln Arg Ile Ser Ser Tyr Lys Lys Phe Ser Arg Val Leu Lys Asn 
            900                 905                 910         


Arg Ala Trp Pro Thr Phe Lys Gln Ala Lys Ser Lys Ile Ser Pro Leu 
        915                 920                 925             


His Ser Ser Asp Phe Cys Pro Thr Asn Cys His Val Asn Val Met Glu 
    930                 935                 940                 


Val Ser Tyr Pro Lys Thr Ser Thr Ser Leu Gly Ser Ala Phe Gly Val 
945                 950                 955                 960 


Gln Leu Asp Ser Arg Lys His Asn Ser His Asp Lys Glu Asn Lys Ser 
                965                 970                 975     


Ser Glu Gln Gly Lys Leu Ser Pro Met Val Tyr Ile Gln His Thr Ile 
            980                 985                 990         


Thr Thr Met Ala Ala Pro Ser Gly  Leu Ser Leu Gly Gln  Gln Asp Gly 
        995                 1000                 1005             


His Gly  Leu Arg Tyr Leu Leu  Lys Glu Glu Asp Leu  Glu Thr Gln 
    1010                 1015                 1020             


Asp Ile  Tyr Gln Lys Leu Leu  Gly Lys Leu Gln Thr  Ala Leu Lys 
    1025                 1030                 1035             


Glu Val  Glu Met Cys Val Cys  Gln Ile Asp Asp Leu  Leu Ser Ser 
    1040                 1045                 1050             


Ile Thr  Tyr Ser Pro Lys Leu  Glu Arg Lys Thr Ser  Glu Gly Ile 
    1055                 1060                 1065             


Ile Pro  Thr Asp Ser Asp Asn  Glu Lys Gly Glu Arg  Asn Ser Lys 
    1070                 1075                 1080             


Arg Val  Cys Phe Asn Val Ala  Gly Asp Glu Gln Glu  Asp Ser Gly 
    1085                 1090                 1095             


His Asp  Thr Ile Ser Asn Arg  Asp Ser Tyr Ser Asp  Cys Asn Ser 
    1100                 1105                 1110             


Asn Arg  Asn Ser Ile Ala Ser  Phe Thr Ser Ile Cys  Ser Ser Gln 
    1115                 1120                 1125             


Cys Ser  Ser Tyr Phe His Ser  Asp Glu Met Asp Ser  Gly Asp Glu 
    1130                 1135                 1140             


Leu Pro  Leu Ser Val Arg Ile  Ser His Asp Lys Gln  Asp Lys Ile 
    1145                 1150                 1155             


His Ser  Cys Leu Glu His Leu  Phe Ser Gln Val Asp  Ser Ile Thr 
    1160                 1165                 1170             


Asn Leu  Leu Lys Gly Gln Ala  Val Val Arg Ala Phe  Asp Gln Thr 
    1175                 1180                 1185             


Lys Tyr  Leu Thr Pro Gly Arg  Gly Leu Gln Glu Phe  Gln Gln Glu 
    1190                 1195                 1200             


Met Glu  Pro Lys Leu Ser Cys  Pro Lys Arg Leu Arg  Leu His Ile 
    1205                 1210                 1215             


Lys Gln  Asp Pro Trp Asn Leu  Pro Ser Ser Val Arg  Thr Leu Ala 
    1220                 1225                 1230             


Gln Asn  Ile Arg Lys Phe Val  Glu Glu Val Lys Cys  Arg Leu Leu 
    1235                 1240                 1245             


Leu Ala  Leu Leu Glu Tyr Ser  Asp Ser Glu Thr Gln  Leu Arg Arg 
    1250                 1255                 1260             


Asp Met  Val Phe Cys Gln Thr  Leu Val Ala Thr Val  Cys Ala Phe 
    1265                 1270                 1275             


Ser Glu  Gln Leu Met Ala Ala  Leu Asn Gln Met Phe  Asp Asn Ser 
    1280                 1285                 1290             


Lys Glu  Asn Glu Met Glu Thr  Trp Glu Ala Ser Arg  Arg Trp Leu 
    1295                 1300                 1305             


Asp Gln  Ile Ala Asn Ala Gly  Val Leu Phe His Phe  Gln Ser Leu 
    1310                 1315                 1320             


Leu Ser  Pro Asn Leu Thr Asp  Glu Gln Ala Met Leu  Glu Asp Thr 
    1325                 1330                 1335             


Leu Val  Ala Leu Phe Asp Leu  Glu Lys Val Ser Phe  Tyr Phe Lys 
    1340                 1345                 1350             


Pro Ser  Glu Glu Glu Pro Leu  Val Ala Asn Val Pro  Leu Thr Tyr 
    1355                 1360                 1365             


Gln Ala  Glu Gly Ser Arg Gln  Ala Leu Lys Val Tyr  Phe Tyr Ile 
    1370                 1375                 1380             


Asp Ser  Tyr His Phe Glu Gln  Leu Pro Gln Arg Leu  Lys Asn Gly 
    1385                 1390                 1395             


Gly Gly  Phe Lys Ile His Pro  Val Leu Phe Ala Gln  Ala Leu Glu 
    1400                 1405                 1410             


Ser Met  Glu Gly Tyr Tyr Tyr  Arg Asp Asn Val Ser  Val Glu Glu 
    1415                 1420                 1425             


Phe Gln  Ala Gln Ile Asn Ala  Ala Ser Leu Glu Lys  Val Lys Gln 
    1430                 1435                 1440             


Tyr Asn  Gln Lys Leu Arg Ala  Phe Tyr Leu Asp Lys  Ser Asn Ser 
    1445                 1450                 1455             


Pro Pro  Asn Ser Thr Ser Lys  Ala Ala Tyr Val Asp  Lys Leu Met 
    1460                 1465                 1470             


Arg Pro  Leu Asn Ala Leu Asp  Glu Leu Tyr Arg Leu  Val Ala Ser 
    1475                 1480                 1485             


Phe Ile  Arg Ser Lys Arg Thr  Ala Ala Cys Ala Asn  Thr Ala Cys 
    1490                 1495                 1500             


Ser Ala  Ser Gly Val Gly Leu  Leu Ser Val Ser Ser  Glu Leu Cys 
    1505                 1510                 1515             


Asn Arg  Leu Gly Ala Cys His  Ile Ile Met Cys Ser  Ser Gly Val 
    1520                 1525                 1530             


His Arg  Cys Thr Leu Ser Val  Thr Leu Glu Gln Ala  Ile Ile Leu 
    1535                 1540                 1545             


Ala Arg  Ser His Gly Leu Pro  Pro Arg Tyr Ile Met  Gln Ala Thr 
    1550                 1555                 1560             


Asp Val  Met Arg Lys Gln Gly  Ala Arg Val Gln Asn  Thr Ala Lys 
    1565                 1570                 1575             


Asn Leu  Gly Val Arg Asp Arg  Thr Pro Gln Ser Ala  Pro Arg Leu 
    1580                 1585                 1590             


Tyr Lys  Leu Cys Glu Pro Pro  Pro Pro Ala Gly Glu  Glu 
    1595                 1600                 1605     


<210>  363
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Ser Glu Asp Ser Arg Gly Asp Ser Arg Ala Glu Ser Ala Lys Asp 
1               5                   10                  15      


Leu Glu Lys Gln Leu Arg Leu Arg Val Cys Val Leu Ser Glu Leu Gln 
            20                  25                  30          


Lys Thr Glu Arg Asp Tyr Val Gly Thr Leu Glu Phe Leu Val Ser Ala 
        35                  40                  45              


Phe Leu His Arg Met Asn Gln Cys Ala Ala Ser Lys Val Asp Lys Asn 
    50                  55                  60                  


Val Thr Glu Glu Thr Val Lys Met Leu Phe Ser Asn Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Ala Val His Lys Glu Phe Leu Lys Val Val Glu Glu Cys Leu His 
                85                  90                  95      


Pro Glu Pro Asn Ala Gln Gln Glu Val Gly Thr Cys Phe Leu His Phe 
            100                 105                 110         


Lys Asp Lys Phe Arg Ile Tyr Asp Glu Tyr Cys Ser Asn His Glu Lys 
        115                 120                 125             


Ala Gln Lys Leu Leu Leu Glu Leu Asn Lys Ile Arg Thr Ile Arg Thr 
    130                 135                 140                 


Phe Leu Leu Asn Cys Met Leu Leu Gly Gly Arg Lys Asn Thr Asp Val 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Leu Val Thr Pro Ile Gln Arg Ile Cys Lys Tyr 
                165                 170                 175     


Pro Leu Ile Leu Lys Glu Leu Leu Lys Arg Thr Pro Arg Lys His Ser 
            180                 185                 190         


Asp Tyr Ala Ala Val Met Glu Ala Leu Gln Ala Met Lys Ala Val Cys 
        195                 200                 205             


Ser Asn Ile Asn Glu Ala Lys Arg Gln Met Glu Lys Leu Glu Val Leu 
    210                 215                 220                 


Glu Glu Trp Gln Ser His Ile Glu Gly Trp Glu Gly Ser Asn Ile Thr 
225                 230                 235                 240 


Asp Thr Cys Thr Glu Met Leu Met Cys Gly Val Leu Leu Lys Ile Ser 
                245                 250                 255     


Ser Gly Asn Ile Gln Glu Arg Val Phe Phe Leu Phe Asp Asn Leu Leu 
            260                 265                 270         


Val Tyr Cys Lys Arg Lys His Arg Arg Leu Lys Asn Ser Lys Ala Ser 
        275                 280                 285             


Thr Asp Gly His Arg Tyr Leu Phe Arg Gly Arg Ile Asn Thr Glu Val 
    290                 295                 300                 


Met Glu Val Glu Asn Val Asp Asp Gly Thr Ala Asp Phe His Ser Ser 
305                 310                 315                 320 


Gly His Ile Val Val Asn Gly Trp Lys Ile His Asn Thr Ala Lys Asn 
                325                 330                 335     


Lys Trp Phe Val Cys Met Ala Lys Thr Pro Glu Glu Lys His Glu Trp 
            340                 345                 350         


Phe Glu Ala Ile Leu Lys Glu Arg Glu Arg Arg Lys Gly Leu Lys Leu 
        355                 360                 365             


Gly Met Glu Gln Asp Thr Trp Val Met Ile Ser Glu Gln Gly Glu Lys 
    370                 375                 380                 


Leu Tyr Lys Met Met Cys Arg Gln Gly Asn Leu Ile Lys Asp Arg Lys 
385                 390                 395                 400 


Arg Lys Leu Thr Thr Phe Pro Lys Cys Phe Leu Gly Ser Glu Phe Val 
                405                 410                 415     


Ser Trp Leu Leu Glu Ile Gly Glu Ile His Arg Pro Glu Glu Gly Val 
            420                 425                 430         


His Leu Gly Gln Ala Leu Leu Glu Asn Gly Ile Ile His His Val Thr 
        435                 440                 445             


Asp Lys His Gln Phe Lys Pro Glu Gln Met Leu Tyr Arg Phe Arg Tyr 
    450                 455                 460                 


Asp Asp Gly Thr Phe Tyr Pro Arg Asn Glu Met Gln Asp Val Ile Ser 
465                 470                 475                 480 


Lys Gly Val Arg Leu Tyr Cys Arg Leu His Ser Leu Phe Thr Pro Val 
                485                 490                 495     


Ile Arg Asp Lys Asp Tyr His Leu Arg Thr Tyr Lys Ser Val Val Met 
            500                 505                 510         


Ala Asn Lys Leu Ile Asp Trp Leu Ile Ala Gln Gly Asp Cys Arg Thr 
        515                 520                 525             


Arg Glu Glu Ala Met Ile Phe Gly Val Gly Leu Cys Asp Asn Gly Phe 
    530                 535                 540                 


Met His His Val Leu Glu Lys Ser Glu Phe Lys Asp Glu Pro Leu Leu 
545                 550                 555                 560 


Phe Arg Phe Phe Ser Asp Glu Glu Met Glu Gly Ser Asn Met Lys His 
                565                 570                 575     


Arg Leu Met Lys His Asp Leu Lys Val Val Glu Asn Val Ile Ala Lys 
            580                 585                 590         


Ser Leu Leu Ile Lys Ser Asn Glu Gly Ser Tyr Gly Phe Gly Leu Glu 
        595                 600                 605             


Asp Lys Asn Lys Val Pro Ile Ile Lys Leu Val Glu Lys Gly Ser Asn 
    610                 615                 620                 


Ala Glu Met Ala Gly Met Glu Val Gly Lys Lys Ile Phe Ala Ile Asn 
625                 630                 635                 640 


Gly Asp Leu Val Phe Met Arg Pro Phe Asn Glu Val Asp Cys Phe Leu 
                645                 650                 655     


Lys Ser Cys Leu Asn Ser Arg Lys Pro Leu Arg Val Leu Val Ser Thr 
            660                 665                 670         


Lys Pro Arg Glu Thr Val Lys Ile Pro Asp Ser Ala Asp Gly Leu Gly 
        675                 680                 685             


Phe Gln Ile Arg Gly Phe Gly Pro Ser Val Val His Ala Val Gly Arg 
    690                 695                 700                 


Gly Thr Val Ala Ala Ala Ala Gly Leu His Pro Gly Gln Cys Ile Ile 
705                 710                 715                 720 


Lys Val Asn Gly Ile Asn Val Ser Lys Glu Thr His Ala Ser Val Ile 
                725                 730                 735     


Ala His Val Thr Ala Cys Arg Lys Tyr Arg Arg Pro Thr Lys Gln Asp 
            740                 745                 750         


Ser Ile Gln Trp Val Tyr Asn Ser Ile Glu Ser Ala Gln Glu Asp Leu 
        755                 760                 765             


Gln Lys Ser His Ser Lys Pro Pro Gly Asp Glu Ala Gly Asp Ala Phe 
    770                 775                 780                 


Asp Cys Lys Val Glu Glu Val Ile Asp Lys Phe Asn Thr Met Ala Ile 
785                 790                 795                 800 


Ile Asp Gly Lys Lys Glu His Val Ser Leu Thr Val Asp Asn Val His 
                805                 810                 815     


Leu Glu Tyr Gly Val Val Tyr Glu Tyr Asp Ser Thr Ala Gly Ile Lys 
            820                 825                 830         


Cys Asn Val Val Glu Lys Met Ile Glu Pro Lys Gly Phe Phe Ser Leu 
        835                 840                 845             


Thr Ala Lys Ile Leu Glu Ala Leu Ala Lys Ser Asp Glu His Phe Val 
    850                 855                 860                 


Gln Asn Cys Thr Ser Leu Asn Ser Leu Asn Glu Val Ile Pro Thr Asp 
865                 870                 875                 880 


Leu Gln Ser Lys Phe Ser Ala Leu Cys Ser Glu Arg Ile Glu His Leu 
                885                 890                 895     


Cys Gln Arg Ile Ser Ser Tyr Lys Lys Val Gln Ala Ser Glu Arg Phe 
            900                 905                 910         


Tyr Asn Phe Thr Ala Arg His Ala Val Trp Glu His Ser Phe Asp Leu 
        915                 920                 925             


His Ser Val Ser Ser Thr Phe Pro Val Pro Val Thr Met Glu Phe Leu 
    930                 935                 940                 


Leu Leu Pro Pro Pro Leu Leu Gly Ile Ser Gln Asp Gly Arg Gln His 
945                 950                 955                 960 


Cys Ile Pro Glu Asp Leu Pro Ser Gln Glu Met Leu Leu Ala Glu Arg 
                965                 970                 975     


Ala Pro Val 
            


<210>  364
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Cys Arg His Arg Arg Arg His Arg Arg Gly Cys Arg Thr Arg Lys 
                85                  90                  95      


Arg Thr Cys Arg Arg His 
            100         


<210>  365
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Cys Arg His Arg Arg Arg His Arg Arg Glu Ser Leu Gly Asp Pro 
                85                  90                  95      


Leu Asn Gln Asn Phe Leu Ser Gln Lys Ala Ala Glu Pro Gly Arg Glu 
            100                 105                 110         


His Ala Glu Gly Thr Lys Leu Pro Gly Pro Leu Thr Pro Ser Trp Lys 
        115                 120                 125             


Leu Arg Lys Ser Arg Pro Lys His Gln Val Arg Pro 
    130                 135                 140 


<210>  366
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg His 
65                  70                  75          


<210>  367
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Cys Arg His Arg Arg Arg His Arg Arg Glu Pro Gly Arg Glu His 
                85                  90                  95      


Ala Glu Gly Thr Lys Leu Pro Gly Pro Leu Thr Pro Ser Trp Lys Leu 
            100                 105                 110         


Arg Lys Ser Arg Pro Lys His Gln Val Arg Pro 
        115                 120             


<210>  368
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Val Arg Tyr Arg Val Arg Ser Leu Ser Glu Arg Ser His Glu Val 
1               5                   10                  15      


Tyr Arg Gln Gln Leu His Gly Gln Glu Gln Gly His His Gly Gln Glu 
            20                  25                  30          


Glu Gln Gly Leu Ser Pro Glu His Val Glu Val Tyr Glu Arg Thr His 
        35                  40                  45              


Gly Gln Ser His Tyr Arg Arg Arg His Cys Ser Arg Arg Arg Leu His 
    50                  55                  60                  


Arg Ile His Arg Arg Gln His Arg Ser Cys Arg Arg Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Cys Arg His Arg Arg Arg His Arg Arg Gly Leu Pro Ala Pro Pro 
                85                  90                  95      


Pro Cys Pro Ala Cys Pro 
            100         


<210>  369
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  370
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 
            20                  25                  30          


Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 
        35                  40                  45              


Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 
    50                  55                  60                  


Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 
65                  70                  75                  80  


Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 
                85                  90                  95      


Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 
            100                 105                 110         


Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 
        115                 120                 125             


Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 
    130                 135                 140                 


Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 
145                 150                 155                 160 


Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 
                165                 170                 175     


Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 
            180                 185                 190         


Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 
        195                 200                 205             


Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 
    210                 215                 220                 


Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 
225                 230                 235                 240 


Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 
                245                 250                 255     


<210>  371
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  372
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Val Gly Glu Thr Tyr 
65                  70                  75                  80  


Gly Lys Asp Ile Thr Ser Arg Gly Lys Asp Lys Pro Ile Ala Asp Val 
                85                  90                  95      


Phe Leu Ile Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val 
            100                 105                 110         


Arg Ala Lys Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro 
        115                 120                 125             


Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr 
    130                 135                 140                 


Ile Glu Lys Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln 
145                 150                 155                 160 


Gly Leu Ala Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys 
                165                 170                 175     


Ser Ala Leu Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile 
            180                 185                 190         


Arg Ala Val Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys 
        195                 200                 205             


Leu Leu Leu 
    210     


<210>  373
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  374
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Cys Lys Gly Leu Ala Ala Leu Pro His Ser Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Ile Lys Ile Lys Leu Gly Ile Leu Leu Gln Lys Pro Asp Ser 
            20                  25                  30          


Val Gly Asp Leu Val Ile Pro Tyr Asn Glu Lys Pro Glu Lys Pro Ala 
        35                  40                  45              


Lys Thr Gln Lys Thr Ser Leu Asp Glu Ala Leu Gln Trp Arg Asp Ser 
    50                  55                  60                  


Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
65                  70                  75                  80  


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
                85                  90                  95      


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
            100                 105                 110         


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
        115                 120                 125             


Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met Lys Asn Leu Val 
    130                 135                 140                 


Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys Arg Ile His Ala 
145                 150                 155                 160 


Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg Ser Glu Phe Tyr 
                165                 170                 175     


Gln Glu Leu Ile Lys 
            180     


<210>  375
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Ala Glu Lys Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu 
1               5                   10                  15      


Ala Pro Lys Glu Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met 
            20                  25                  30          


Lys Asn Leu Val Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys 
        35                  40                  45              


Arg Ile His Ala Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg 
    50                  55                  60                  


Ser Glu Phe Tyr Gln Glu Leu Ile Lys 
65                  70              


<210>  376
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Cys Lys Gly Leu Ala Ala Leu Pro His Ser Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Ile Lys Ile Lys Leu Gly Ile Leu Leu Gln Lys Pro Asp Ser 
            20                  25                  30          


Val Gly Asp Leu Val Ile Pro Tyr Asn Glu Lys Pro Glu Lys Pro Ala 
        35                  40                  45              


Lys Thr Gln Lys Thr Ser Leu Asp Glu Ala Leu Gln Trp Arg Asp Ser 
    50                  55                  60                  


Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
65                  70                  75                  80  


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
                85                  90                  95      


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
            100                 105                 110         


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
        115                 120                 125             


Val Gly Leu Trp Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met 
    130                 135                 140                 


Lys Asn Leu Val Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys 
145                 150                 155                 160 


Arg Ile His Ala Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg 
                165                 170                 175     


Ser Glu Phe Tyr Gln Glu Leu Ile Lys 
            180                 185 


<210>  377
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Gln Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Arg Ser Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Ser Ala Phe Gly Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Gly Leu Gln Val Arg Lys Asn Lys Arg Arg Arg Gly Cys Pro Ile 
            180                 185                 190         


Leu 
    


<210>  378
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Gln Ala Ser Pro Leu Gln Thr Ser Gln Pro Thr Pro Pro Glu Glu 
1               5                   10                  15      


Leu His Ala Ala Ala Tyr Val Phe Thr Asn Asp Gly Gln Gln Met Arg 
            20                  25                  30          


Ser Asp Glu Val Asn Leu Val Ala Thr Gly His Gln Ser Lys Lys Lys 
        35                  40                  45              


His Ser Arg Lys Ser Lys Arg His Ser Ser Ser Lys Arg Arg Lys Ser 
    50                  55                  60                  


Met Ser Ser Trp Leu Asp Lys Gln Glu Asp Ala Ala Val Thr His Ser 
65                  70                  75                  80  


Ile Cys Glu Glu Arg Ile Asn Asn Gly Gln Pro Val Ala Asp Asn Val 
                85                  90                  95      


Leu Ser Thr Ala Pro Pro Trp Pro Asp Ala Thr Ile Ala His Asn Ile 
            100                 105                 110         


Arg Glu Glu Arg Met Glu Asn Gly Gln Ser Arg Thr Asp Lys Val Leu 
        115                 120                 125             


Ser Thr Ala Pro Pro Gln Leu Val His Met Ala Ala Ala Gly Ile Pro 
    130                 135                 140                 


Ser Met Ser Thr Arg Asp Leu His Ser Thr Val Thr His Asn Ile Arg 
145                 150                 155                 160 


Glu Glu Arg Met Glu Asn Gly Gln Pro Gln Pro Asp Asn Val Leu Ser 
                165                 170                 175     


Thr Gly Pro Thr Gly Leu Ile Asn Met Ala Ala Thr Pro Ile Pro Ala 
            180                 185                 190         


Met Ser Ala Arg Asp Leu Tyr Ala Thr Val Thr His Asn Val Cys Glu 
        195                 200                 205             


Gln Lys Met Glu Asn Val Gln Pro Ala Pro Asp Asn Val Leu Leu Thr 
    210                 215                 220                 


Leu Arg Pro Arg Arg Ile Asn Met Thr Asp Thr Gly Ile Ser Pro Met 
225                 230                 235                 240 


Ser Thr Arg Asp Pro Tyr Ala Thr Ile Thr Tyr Asn Val Pro Glu Glu 
                245                 250                 255     


Lys Met Glu Lys Gly Gln Pro Gln Pro Asp Asn Ile Leu Ser Thr Ala 
            260                 265                 270         


Ser Thr Gly Leu Ile Asn Val Ala Gly Ala Gly Thr Pro Ala Ile Ser 
        275                 280                 285             


Thr Asn Gly Leu Tyr Ser Thr Val Pro His Asn Val Cys Glu Glu Lys 
    290                 295                 300                 


Met Glu Asn Asp Gln Pro Gln Pro Asn Asn Val Leu Ser Thr Val Gln 
305                 310                 315                 320 


Pro Val Ile Ile Tyr Leu Thr Ala Thr Gly Ile Pro Gly Met Asn Thr 
                325                 330                 335     


Arg Asp Gln Tyr Ala Thr Ile Thr His Asn Val Cys Glu Glu Arg Val 
            340                 345                 350         


Val Asn Asn Gln Pro Leu Pro Ser Asn Ala Leu Ser Thr Val Leu Pro 
        355                 360                 365             


Gly Leu Ala Tyr Leu Ala Thr Ala Asp Met Pro Ala Met Ser Thr Arg 
    370                 375                 380                 


Asp Gln His Ala Thr Ile Ile His Asn Leu Arg Glu Glu Lys Lys Asp 
385                 390                 395                 400 


Asn Ser Gln Pro Thr Pro Asp Asn Val Leu Ser Ala Val Thr Pro Glu 
                405                 410                 415     


Leu Ile Asn Leu Ala Gly Ala Gly Ile Pro Pro Met Ser Thr Arg Asp 
            420                 425                 430         


Gln Tyr Ala Thr Val Asn His His Val His Glu Ala Arg Met Glu Asn 
        435                 440                 445             


Gly Gln Arg Lys Gln Asp Asn Val Leu Ser Asn Val Leu Ser Gly Leu 
    450                 455                 460                 


Ile Asn Met Ala Gly Ala Ser Ile Pro Ala Met Ser Ser Arg Asp Leu 
465                 470                 475                 480 


Tyr Ala Thr Ile Thr His Ser Val Arg Glu Glu Lys Met Glu Ser Gly 
                485                 490                 495     


Lys Pro Gln Thr Asp Lys Val Ile Ser Asn Asp Ala Pro Gln Leu Gly 
            500                 505                 510         


His Met Ala Ala Gly Gly Ile Pro Ser Met Ser Thr Lys Asp Leu Tyr 
        515                 520                 525             


Ala Thr Val Thr Gln Asn Val His Glu Glu Arg Met Glu Asn Asn Gln 
    530                 535                 540                 


Pro Gln Pro Ser Tyr Asp Leu Ser Thr Val Leu Pro Gly Leu Thr Tyr 
545                 550                 555                 560 


Leu Thr Val Ala Gly Ile Pro Ala Met Ser Thr Arg Asp Gln Tyr Ala 
                565                 570                 575     


Thr Val Thr His Asn Val His Glu Glu Lys Ile Lys Asn Gly Gln Ala 
            580                 585                 590         


Ala Ser Asp Asn Val Phe Ser Thr Val Pro Pro Ala Phe Ile Asn Met 
        595                 600                 605             


Ala Ala Thr Gly Val Ser Ser Met Ser Thr Arg Asp Gln Tyr Ala Ala 
    610                 615                 620                 


Val Thr His Asn Ile Arg Glu Glu Lys Ile Asn Asn Ser Gln Pro Ala 
625                 630                 635                 640 


Pro Gly Asn Ile Leu Ser Thr Ala Pro Pro Trp Leu Arg His Met Ala 
                645                 650                 655     


Ala Ala Gly Ile Ser Ser Thr Ile Thr Arg Asp Leu Tyr Val Thr Ala 
            660                 665                 670         


Thr His Ser Val His Glu Glu Lys Met Thr Asn Gly Gln Gln Ala Pro 
        675                 680                 685             


Asp Asn Ser Leu Ser Thr Val Pro Pro Gly Cys Ile Asn Leu Ser Gly 
    690                 695                 700                 


Ala Gly Ile Ser Cys Arg Ser Thr Arg Asp Leu Tyr Ala Thr Val Ile 
705                 710                 715                 720 


His Asp Ile Gln Glu Glu Glu Met Glu Asn Asp Gln Thr Pro Pro Asp 
                725                 730                 735     


Gly Phe Leu Ser Asn Ser Asp Ser Pro Glu Leu Ile Asn Met Thr Gly 
            740                 745                 750         


His Cys Met Pro Pro Asn Ala Leu Asp Ser Phe Ser His Asp Phe Thr 
        755                 760                 765             


Ser Leu Ser Lys Asp Glu Leu Leu Tyr Lys Pro Asp Ser Asn Glu Phe 
    770                 775                 780                 


Ala Val Gly Thr Lys Asn Tyr Ser Val Ser Ala Gly Asp Pro Pro Val 
785                 790                 795                 800 


Thr Val Met Ser Leu Val Glu Thr Val Pro Asn Thr Pro Gln Ile Ser 
                805                 810                 815     


Pro Ala Met Ala Lys Lys Ile Asn Asp Asp Ile Lys Tyr Gln Leu Met 
            820                 825                 830         


Lys Glu Val Arg Arg Phe Gly Gln Asn Tyr Glu Arg Ile Phe Ile Leu 
        835                 840                 845             


Leu Glu Glu Val Gln Gly Ser Met Lys Val Lys Arg Gln Phe Val Glu 
    850                 855                 860                 


Phe Thr Ile Lys Glu Ala Ala Arg Phe Lys Lys Val Val Leu Ile Gln 
865                 870                 875                 880 


Gln Leu Glu Lys Ala Leu Lys Glu Ile Asp Ser His Cys His Leu Arg 
                885                 890                 895     


Lys Val Lys His Met Arg Lys Arg 
            900                 


<210>  379
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ala Thr Ala Ala Glu Thr Ser Ala Ser Glu Pro Glu Ala Glu Ser 
1               5                   10                  15      


Lys Ala Gly Pro Lys Ala Asp Gly Glu Glu Asp Glu Val Lys Ala Ala 
            20                  25                  30          


Arg Thr Arg Arg Lys Val Leu Ser Arg Ala Val Ala Ala Ala Thr Tyr 
        35                  40                  45              


Lys Thr Met Gly Pro Ala Trp Asp Gln Gln Glu Glu Gly Val Ser Glu 
    50                  55                  60                  


Ser Asp Gly Asp Glu Tyr Ala Met Ala Ser Ser Ala Glu Ser Ser Pro 
65                  70                  75                  80  


Gly Glu Tyr Glu Trp Glu Tyr Asp Glu Glu Glu Glu Lys Asn Gln Leu 
                85                  90                  95      


Glu Ile Glu Arg Leu Glu Glu Gln Leu Ser Ile Asn Val Tyr Asp Tyr 
            100                 105                 110         


Asn Cys His Val Asp Leu Ile Arg Leu Leu Arg Leu Glu Gly Glu Leu 
        115                 120                 125             


Thr Lys Val Arg Met Ala Arg Gln Lys Met Ser Glu Ile Phe Pro Leu 
    130                 135                 140                 


Thr Glu Glu Leu Trp Leu Glu Trp Leu His Asp Glu Ile Ser Met Ala 
145                 150                 155                 160 


Gln Asp Gly Leu Asp Arg Glu His Val Tyr Asp Leu Phe Glu Lys Ala 
                165                 170                 175     


Val Lys Asp Tyr Ile Cys Pro Asn Ile Trp Leu Glu Tyr Gly Gln Tyr 
            180                 185                 190         


Ser Val Gly Gly Ile Gly Gln Lys Gly Gly Leu Glu Lys Val Arg Ser 
        195                 200                 205             


Val Phe Glu Arg Ala Leu Ser Ser Val Gly Leu His Met Thr Lys Gly 
    210                 215                 220                 


Leu Ala Leu Trp Glu Ala Tyr Arg Glu Phe Glu Ser Ala Ile Val Glu 
225                 230                 235                 240 


Ala Ala Arg Leu Glu Lys Val His Ser Leu Phe Arg Arg Gln Leu Ala 
                245                 250                 255     


Ile Pro Leu Tyr Asp Met Glu Ala Thr Phe Ala Glu Tyr Glu Glu Trp 
            260                 265                 270         


Ser Glu Asp Pro Ile Pro Glu Ser Val Ile Gln Asn Tyr Asn Lys Ala 
        275                 280                 285             


Leu Gln Gln Leu Glu Lys Tyr Lys Pro Tyr Glu Glu Ala Leu Leu Gln 
    290                 295                 300                 


Ala Glu Ala Pro Arg Leu Ala Glu Tyr Gln Ala Tyr Ile Asp Phe Glu 
305                 310                 315                 320 


Met Lys Ile Gly Asp Pro Ala Arg Ile Gln Leu Ile Phe Glu Arg Ala 
                325                 330                 335     


Leu Val Glu Asn Cys Leu Val Pro Asp Leu Trp Ile Arg Tyr Ser Gln 
            340                 345                 350         


Tyr Leu Asp Arg Gln Leu Lys Val Lys Asp Leu Val Leu Ser Val His 
        355                 360                 365             


Asn Arg Ala Ile Arg Asn Cys Pro Trp Thr Val Ala Leu Trp Ser Arg 
    370                 375                 380                 


Tyr Leu Leu Ala Met Glu Arg His Gly Val Asp His Gln Val Ile Ser 
385                 390                 395                 400 


Val Thr Phe Glu Lys Ala Leu Asn Ala Gly Phe Ile Gln Ala Thr Asp 
                405                 410                 415     


Tyr Val Glu Ile Trp Gln Ala Tyr Leu Asp Tyr Leu Arg Arg Arg Val 
            420                 425                 430         


Asp Phe Lys Gln Asp Ser Ser Lys Glu Leu Glu Glu Leu Arg Ala Ala 
        435                 440                 445             


Phe Thr Arg Ala Leu Glu Tyr Leu Lys Gln Glu Val Glu Glu Arg Phe 
    450                 455                 460                 


Asn Glu Ser Gly Asp Pro Ser Cys Val Ile Met Gln Asn Trp Ala Arg 
465                 470                 475                 480 


Ile Glu Ala Arg Leu Cys Asn Asn Met Gln Lys Ala Arg Glu Leu Trp 
                485                 490                 495     


Asp Ser Ile Met Thr Arg Gly Asn Ala Lys Tyr Ala Asn Met Trp Leu 
            500                 505                 510         


Glu Tyr Tyr Asn Leu Glu Arg Ala His Gly Asp Thr Gln His Cys Arg 
        515                 520                 525             


Lys Ala Leu His Arg Ala Val Gln Cys Thr Ser Asp Tyr Pro Glu His 
    530                 535                 540                 


Val Cys Glu Val Leu Leu Thr Met Glu Arg Thr Glu Gly Ser Leu Glu 
545                 550                 555                 560 


Asp Trp Asp Ile Ala Val Gln Lys Thr Glu Thr Arg Leu Ala Arg Val 
                565                 570                 575     


Asn Glu Gln Arg Met Lys Ala Ala Glu Lys Glu Ala Ala Leu Val Gln 
            580                 585                 590         


Gln Glu Glu Glu Lys Ala Glu Gln Arg Lys Arg Ala Arg Ala Glu Lys 
        595                 600                 605             


Lys Ala Leu Lys Lys Lys Lys Lys Ile Arg Gly Pro Glu Lys Arg Gly 
    610                 615                 620                 


Ala Asp Glu Asp Asp Glu Lys Glu Trp Gly Asp Asp Glu Glu Glu Gln 
625                 630                 635                 640 


Pro Ser Lys Arg Arg Arg Val Glu Asn Ser Ile Pro Ala Ala Gly Glu 
                645                 650                 655     


Thr Gln Asn Val Glu Val Ala Ala Gly Pro Ala Gly Lys Cys Ala Ala 
            660                 665                 670         


Val Asp Val Glu Pro Pro Ser Lys Gln Lys Glu Lys Ala Ala Ser Leu 
        675                 680                 685             


Lys Arg Asp Met Pro Lys Val Leu His Asp Ser Ser Lys Asp Ser Ile 
    690                 695                 700                 


Thr Val Phe Val Ser Asn Leu Pro Tyr Ser Met Gln Glu Pro Asp Thr 
705                 710                 715                 720 


Lys Leu Arg Pro Leu Phe Glu Ala Cys Gly Glu Val Val Gln Ile Arg 
                725                 730                 735     


Pro Ile Phe Ser Asn Arg Gly Asp Phe Arg Gly Tyr Cys Tyr Val Glu 
            740                 745                 750         


Phe Lys Glu Glu Lys Ser Ala Leu Gln Ala Leu Glu Met Asp Arg Lys 
        755                 760                 765             


Ser Val Glu Gly Arg Pro Met Phe Val Ser Pro Cys Val Asp Lys Ser 
    770                 775                 780                 


Lys Asn Pro Asp Phe Lys Val Phe Arg Tyr Ser Thr Ser Leu Glu Lys 
785                 790                 795                 800 


His Lys Leu Phe Ile Ser Gly Leu Pro Phe Ser Cys Thr Lys Glu Glu 
                805                 810                 815     


Leu Glu Glu Ile Cys Lys Ala His Gly Thr Val Lys Asp Leu Arg Leu 
            820                 825                 830         


Val Thr Asn Arg Ala Gly Lys Pro Lys Gly Leu Ala Tyr Val Glu Tyr 
        835                 840                 845             


Glu Asn Glu Ser Gln Ala Ser Gln Ala Val Met Lys Met Asp Gly Met 
    850                 855                 860                 


Thr Ile Lys Glu Asn Ile Ile Lys Val Ala Ile Ser Asn Pro Pro Gln 
865                 870                 875                 880 


Arg Lys Val Pro Glu Lys Pro Glu Thr Arg Lys Ala Pro Gly Gly Pro 
                885                 890                 895     


Met Leu Leu Pro Gln Thr Tyr Gly Ala Arg Gly Lys Gly Arg Thr Gln 
            900                 905                 910         


Leu Ser Leu Leu Pro Arg Ala Leu Gln Arg Pro Ser Ala Ala Ala Pro 
        915                 920                 925             


Gln Ala Glu Asn Gly Pro Ala Ala Ala Pro Ala Val Ala Ala Pro Ala 
    930                 935                 940                 


Ala Thr Glu Ala Pro Lys Met Ser Asn Ala Asp Phe Ala Lys Leu Phe 
945                 950                 955                 960 


Leu Arg Lys 
            


<210>  380
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Lys Ser Ser Gly Leu Phe Pro Phe Leu Val Leu Leu Ala Leu Gly 
1               5                   10                  15      


Thr Leu Ala Pro Trp Ala Val Glu Gly Ser Gly Lys Ser Phe Lys Ala 
            20                  25                  30          


Gly Val Cys Pro Pro Lys Lys Ser Ala Gln Cys Leu Arg Tyr Lys Lys 
        35                  40                  45              


Pro Glu Cys Gln Ser Asp Trp Gln Cys Pro Gly Lys Lys Arg Cys Cys 
    50                  55                  60                  


Pro Asp Thr Cys Gly Ile Lys Cys Leu Asp Pro Val Asp Thr Pro Asn 
65                  70                  75                  80  


Pro Thr Arg Arg Lys Pro Gly Lys Cys Pro Val Thr Tyr Gly Gln Cys 
                85                  90                  95      


Leu Met Leu Asn Pro Pro Asn Phe Cys Glu Met Asp Gly Gln Cys Lys 
            100                 105                 110         


Arg Asp Leu Lys Cys Cys Met Gly Met Cys Gly Lys Ser Cys Val Ser 
        115                 120                 125             


Pro Val Lys Ala 
    130         


<210>  381
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Ala Glu Gln Gly Gly Thr Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Gly Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Met Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Ala Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Ser Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Ala Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ser Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210>  382
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Ser Ile Pro Phe Ser Asn Thr His Tyr Arg Ile Pro Gln Gly Phe 
1               5                   10                  15      


Gly Asn Leu Leu Glu Gly Leu Thr Arg Glu Ile Leu Arg Glu Gln Pro 
            20                  25                  30          


Asp Asn Ile Pro Ala Phe Ala Ala Ala Tyr Phe Glu Ser Leu Leu Glu 
        35                  40                  45              


Lys Arg Glu Lys Thr Asn Phe Asp Pro Ala Glu Trp Gly Ser Lys Val 
    50                  55                  60                  


Glu Asp Arg Phe Tyr Asn Asn His Ala Phe Glu Glu Gln Glu Pro Pro 
65                  70                  75                  80  


Glu Lys Ser Asp Pro Lys Gln Glu Glu Ser Gln Ile Ser Gly Lys Glu 
                85                  90                  95      


Glu Glu Thr Ser Val Thr Ile Leu Asp Ser Ser Glu Glu Asp Lys Glu 
            100                 105                 110         


Lys Glu Glu Val Ala Ala Val Lys Ile Gln Ala Ala Phe Arg Gly His 
        115                 120                 125             


Ile Ala Arg Glu Glu Ala Lys Lys Met Lys Thr Asn Ser Leu Gln Asn 
    130                 135                 140                 


Glu Glu Lys Glu Glu Asn Lys 
145                 150     


<210>  383
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Asn Arg Glu Ala 
145                 150                 155                 160 


Gln Glu Lys Glu Glu Arg Arg Gly Thr Ala His Arg Trp Ser Ser Gln 
                165                 170                 175     


Asn Thr His Asn Ile Gly Arg Phe Ser Leu Ser Thr Ser Met Gly Ala 
            180                 185                 190         


Val His Gly Thr Pro Lys Thr Ile Thr His Asn Arg Asp Pro Lys Gly 
        195                 200                 205             


Gly Asn Met Pro Gly Pro Thr Asp Cys Val Arg Glu Asn Ser Trp 
    210                 215                 220             


<210>  384
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  385
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Asn Arg Glu Ala 
145                 150                 155                 160 


Gln Glu Lys Glu Glu Arg Arg Gly Thr Ala His Arg Trp Ser Ser Gln 
                165                 170                 175     


Asn Thr His Asn Ile Gly Pro Lys Arg Gly Glu His Ala Trp Thr His 
            180                 185                 190         


Arg Leu Arg Glu Arg Lys Gln Leu Val Ile Tyr Glu Glu Ile Ser Asp 
        195                 200                 205             


Pro Glu Glu Asp Asp Glu 
    210                 


<210>  386
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Arg Thr Lys Ala Ala Gly Cys Ala Glu Arg Arg Pro Leu Gln Pro 
1               5                   10                  15      


Arg Thr Glu Ala Ala Ala Ala Pro Ala Gly Arg Ala Met Pro Ser Glu 
            20                  25                  30          


Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg Pro Ser Leu Gln 
        35                  40                  45              


Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro Ser Leu Leu Leu 
    50                  55                  60                  


Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly Val Trp Ile Leu 
65                  70                  75                  80  


Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys Asp Met Lys Lys 
                85                  90                  95      


Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala Gln Lys Tyr Ala 
            100                 105                 110         


Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe Ala Lys Thr Ser 
        115                 120                 125             


Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
    130                 135                 140                 


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
145                 150                 155                 160 


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
                165                 170                 175     


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
            180                 185                 190         


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
        195                 200                 205             


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
    210                 215                 220                 


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
225                 230                 235                 240 


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
                245                 250                 255     


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
            260                 265                 270         


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
        275                 280                 285             


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
    290                 295                 300                 


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
                325                 330                 335     


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
            340                 345                 350         


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
        355                 360                 365             


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
    370                 375                 380                 


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
                405                 410                 415     


Glu Phe 
        


<210>  387
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ala Ser Val Pro Met Pro Ser Glu Tyr Thr Tyr Val Lys Leu Arg 
1               5                   10                  15      


Ser Asp Cys Ser Arg Pro Ser Leu Gln Trp Tyr Thr Arg Ala Gln Ser 
            20                  25                  30          


Lys Met Arg Arg Pro Ser Leu Leu Leu Lys Asp Ile Leu Lys Cys Thr 
        35                  40                  45              


Leu Leu Val Phe Gly Val Trp Ile Leu Tyr Ile Leu Lys Leu Asn Tyr 
    50                  55                  60                  


Thr Thr Glu Glu Cys Asp Met Lys Lys Met His Tyr Val Asp Pro Asp 
65                  70                  75                  80  


His Val Lys Arg Ala Gln Lys Tyr Ala Gln Gln Val Leu Gln Lys Glu 
                85                  90                  95      


Cys Arg Pro Lys Phe Ala Lys Thr Ser Met Ala Leu Leu Phe Glu His 
            100                 105                 110         


Arg Tyr Ser Val Asp Leu Leu Pro Phe Val Gln Lys Ala Pro Lys Asp 
        115                 120                 125             


Ser Glu Ala Glu Ser Lys Tyr Asp Pro Pro Phe Gly Phe Arg Lys Phe 
    130                 135                 140                 


Ser Ser Lys Val Gln Thr Leu Leu Glu Leu Leu Pro Glu His Asp Leu 
145                 150                 155                 160 


Pro Glu His Leu Lys Ala Lys Thr Cys Arg Arg Cys Val Val Ile Gly 
                165                 170                 175     


Ser Gly Gly Ile Leu His Gly Leu Glu Leu Gly His Thr Leu Asn Gln 
            180                 185                 190         


Phe Asp Val Val Ile Arg Leu Asn Ser Ala Pro Val Glu Gly Tyr Ser 
        195                 200                 205             


Glu His Val Gly Asn Lys Thr Thr Ile Arg Met Thr Tyr Pro Glu Gly 
    210                 215                 220                 


Ala Pro Leu Ser Asp Leu Glu Tyr Tyr Ser Asn Asp Leu Phe Val Ala 
225                 230                 235                 240 


Val Leu Phe Lys Ser Val Asp Phe Asn Trp Leu Gln Ala Met Val Lys 
                245                 250                 255     


Lys Glu Thr Leu Pro Phe Trp Val Arg Leu Phe Phe Trp Lys Gln Val 
            260                 265                 270         


Ala Glu Lys Ile Pro Leu Gln Pro Lys His Phe Arg Ile Leu Asn Pro 
        275                 280                 285             


Val Ile Ile Lys Glu Thr Ala Phe Asp Ile Leu Gln Tyr Ser Glu Pro 
    290                 295                 300                 


Gln Ser Arg Phe Trp Gly Arg Asp Lys Asn Val Pro Thr Ile Gly Val 
305                 310                 315                 320 


Ile Ala Val Val Leu Ala Thr His Leu Cys Asp Glu Val Ser Leu Ala 
                325                 330                 335     


Gly Phe Gly Tyr Asp Leu Asn Gln Pro Arg Thr Pro Leu His Tyr Phe 
            340                 345                 350         


Asp Ser Gln Cys Met Ala Ala Met Asn Phe Gln Thr Met His Asn Val 
        355                 360                 365             


Thr Thr Glu Thr Lys Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val 
    370                 375                 380                 


Lys Asp Leu Ser Gly Gly Ile Asp Arg Glu Phe 
385                 390                 395 


<210>  388
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
1               5                   10                  15      


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
            20                  25                  30          


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
        35                  40                  45              


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
    50                  55                  60                  


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
                85                  90                  95      


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
            100                 105                 110         


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
        115                 120                 125             


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
    130                 135                 140                 


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
145                 150                 155                 160 


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
                165                 170                 175     


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
            180                 185                 190         


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
        195                 200                 205             


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
    210                 215                 220                 


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
225                 230                 235                 240 


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
                245                 250                 255     


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
            260                 265                 270         


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
        275                 280                 285             


Glu Phe 
    290 


<210>  389
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Pro Ser Glu Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg 
1               5                   10                  15      


Pro Ser Leu Gln Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro 
            20                  25                  30          


Ser Leu Leu Leu Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly 
        35                  40                  45              


Val Trp Ile Leu Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys 
    50                  55                  60                  


Asp Met Lys Lys Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala 
65                  70                  75                  80  


Gln Lys Tyr Ala Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe 
                85                  90                  95      


Ala Lys Thr Ser Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp 
            100                 105                 110         


Leu Leu Pro Phe Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser 
        115                 120                 125             


Lys Tyr Asp Pro Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln 
    130                 135                 140                 


Thr Leu Leu Glu Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys 
145                 150                 155                 160 


Ala Lys Thr Cys Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu 
                165                 170                 175     


His Gly Leu Glu Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile 
            180                 185                 190         


Arg Leu Asn Ser Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn 
        195                 200                 205             


Lys Thr Thr Ile Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp 
    210                 215                 220                 


Leu Glu Tyr Tyr Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser 
225                 230                 235                 240 


Val Asp Phe Asn Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro 
                245                 250                 255     


Phe Trp Val Arg Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro 
            260                 265                 270         


Leu Gln Pro Lys His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu 
        275                 280                 285             


Thr Ala Phe Asp Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp 
    290                 295                 300                 


Gly Arg Asp Lys Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu 
305                 310                 315                 320 


Ala Thr His Leu Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp 
                325                 330                 335     


Leu Asn Gln Pro Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met 
            340                 345                 350         


Ala Ala Met Asn Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys 
        355                 360                 365             


Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly 
    370                 375                 380                 


Gly Ile Asp Arg Glu Phe 
385                 390 


<210>  390
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr Ser 
1               5                   10                  15      


Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn Trp 
            20                  25                  30          


Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg Leu 
        35                  40                  45              


Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys His 
    50                  55                  60                  


Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp Ile 
65                  70                  75                  80  


Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys Asn 
                85                  90                  95      


Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu Cys 
            100                 105                 110         


Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro Arg 
        115                 120                 125             


Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn Phe 
    130                 135                 140                 


Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys Leu 
145                 150                 155                 160 


Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg Glu 
                165                 170                 175     


Phe 
    


<210>  391
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Ser Pro Cys Gly Arg Ala Arg Arg Gln Thr Ser Arg Gly Ala Met 
1               5                   10                  15      


Ala Val Leu Ala Trp Lys Phe Pro Arg Thr Arg Leu Pro Met Gly Ala 
            20                  25                  30          


Ser Ala Leu Cys Val Val Val Leu Cys Trp Leu Tyr Ile Phe Pro Val 
        35                  40                  45              


Tyr Arg Leu Pro Asn Glu Lys Glu Ile Val Gln Gly Val Leu Gln Gln 
    50                  55                  60                  


Gly Thr Ala Trp Arg Arg Asn Gln Thr Ala Ala Arg Ala Phe Arg Lys 
65                  70                  75                  80  


Gln Met Glu Asp Cys Cys Asp Pro Ala His Leu Phe Ala Met Thr Lys 
                85                  90                  95      


Met Asn Ser Pro Met Gly Lys Ser Met Trp Tyr Asp Gly Glu Phe Leu 
            100                 105                 110         


Tyr Ser Phe Thr Ile Asp Asn Ser Thr Tyr Ser Leu Phe Pro Gln Ala 
        115                 120                 125             


Thr Pro Phe Gln Leu Pro Leu Lys Lys Cys Ala Val Val Gly Asn Gly 
    130                 135                 140                 


Gly Ile Leu Lys Lys Ser Gly Cys Gly Arg Gln Ile Asp Glu Ala Asn 
145                 150                 155                 160 


Phe Val Met Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr Lys 
                165                 170                 175     


Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile Ile 
            180                 185                 190         


Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val Asp 
        195                 200                 205             


Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe Ser 
    210                 215                 220                 


Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu Ser 
225                 230                 235                 240 


Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe Leu 
                245                 250                 255     


Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys Arg 
            260                 265                 270         


Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys Glu 
        275                 280                 285             


Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His Glu 
    290                 295                 300                 


Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser Gly 
305                 310                 315                 320 


Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His Lys 
                325                 330                 335     


Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser Leu 
            340                 345                 350         


Gln Pro Thr Ser 
        355     


<210>  392
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Thr Gly Ser Phe Tyr Thr His Ser Pro Leu Thr Ile Gln Leu Thr 
1               5                   10                  15      


Leu Ser Ser His Arg Cys Asn Leu Pro Pro Leu Ser Ser Glu Tyr Thr 
            20                  25                  30          


Lys Asp Val Gly Ser Lys Ser Gln Leu Val Thr Ala Asn Pro Ser Ile 
        35                  40                  45              


Ile Arg Gln Arg Phe Gln Asn Leu Leu Trp Ser Arg Lys Thr Phe Val 
    50                  55                  60                  


Asp Asn Met Lys Ile Tyr Asn His Ser Tyr Ile Tyr Met Pro Ala Phe 
65                  70                  75                  80  


Ser Met Lys Thr Gly Thr Glu Pro Ser Leu Arg Val Tyr Tyr Thr Leu 
                85                  90                  95      


Ser Asp Val Gly Ala Asn Gln Thr Val Leu Phe Ala Asn Pro Asn Phe 
            100                 105                 110         


Leu Arg Ser Ile Gly Lys Phe Trp Lys Ser Arg Gly Ile His Ala Lys 
        115                 120                 125             


Arg Leu Ser Thr Gly Leu Phe Leu Val Ser Ala Ala Leu Gly Leu Cys 
    130                 135                 140                 


Glu Glu Val Ala Ile Tyr Gly Phe Trp Pro Phe Ser Val Asn Met His 
145                 150                 155                 160 


Glu Gln Pro Ile Ser His His Tyr Tyr Asp Asn Val Leu Pro Phe Ser 
                165                 170                 175     


Gly Phe His Ala Met Pro Glu Glu Phe Leu Gln Leu Trp Tyr Leu His 
            180                 185                 190         


Lys Ile Gly Ala Leu Arg Met Gln Leu Asp Pro Cys Glu Asp Thr Ser 
        195                 200                 205             


Leu Gln Pro Thr Ser 
    210             


<210>  393
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  394
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Gln Arg Lys Pro Thr Ile 
65                  70                  75                  80  


Arg Arg Lys Asn Leu Arg Lys Leu Arg Arg Lys Cys Ala Val Pro Ser 
                85                  90                  95      


Ser Ser Trp Leu Pro Trp Ile Glu Ala Ser Gly Arg Ser Cys Leu Val 
            100                 105                 110         


Pro Glu Trp Leu His His Phe Gln Gly Leu Phe Pro Gly Ala Thr Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Leu Ala Met Ser 
    130                 135         


<210>  395
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Thr Val Ala 
65                  70                  75                  80  


Tyr Ala Cys Asn Thr Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Thr 
                85                  90                  95      


Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala Phe Leu Ser Val 
            100                 105                 110         


Lys Lys Gln Phe Glu Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu Asp 
        115                 120                 125             


Arg Glu Arg Ala Lys Asn Lys Ile Ala Lys Glu Thr Asn Asn Lys Lys 
    130                 135                 140                 


Lys Glu Phe Glu Glu Thr Ala Glu Lys Val Arg Arg Ala Ile Glu Gln 
145                 150                 155                 160 


Leu Ala Ala Met Asp 
                165 


<210>  396
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Leu Gln Asp Lys Gly Leu Ser Glu Ser Glu Glu Ala Phe Arg Ala 
1               5                   10                  15      


Pro Gly Pro Ala Leu Gly Glu Ala Ser Ala Ala Asn Ala Pro Glu Pro 
            20                  25                  30          


Ala Leu Ala Ala Pro Gly Leu Ser Gly Ala Ala Leu Gly Ser Pro Pro 
        35                  40                  45              


Gly Pro Gly Ala Asp Val Val Ala Ala Ala Ala Ala Glu Gln Thr Ile 
    50                  55                  60                  


Glu Asn Ile Lys Val Gly Leu His Glu Lys Glu Leu Trp Lys Lys Phe 
65                  70                  75                  80  


His Glu Ala Gly Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met 
                85                  90                  95      


Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Met Asn Pro Lys Thr Lys 
            100                 105                 110         


Tyr Ile Leu Leu Ile Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys 
        115                 120                 125             


Phe Cys Asp Asn Lys Trp Met Val Ala Gly Lys Ala Glu Pro Ala Met 
    130                 135                 140                 


Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His 
145                 150                 155                 160 


Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu Thr Asn Asn 
                165                 170                 175     


His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr 
            180                 185                 190         


Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Ala Phe Gly 
        195                 200                 205             


Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ser Phe 
    210                 215                 220                 


Ile Ser Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile 
225                 230                 235                 240 


Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Ser Asp 
                245                 250                 255     


Leu Arg Val Ala Arg Leu Gln Ser Lys Glu Tyr Pro Val Ile Ser Lys 
            260                 265                 270         


Ser Ile Met Arg Gln Arg Leu Ile Ser Pro Gln Leu Ser Ala Thr Pro 
        275                 280                 285             


Asp Val Gly Pro Leu Leu Gly Thr His Gln Ala Leu Gln His Tyr Gln 
    290                 295                 300                 


His Glu Asn Gly Ala His Ser Gln Leu Ala Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Leu Ser Thr Phe Pro Thr Gln Arg Asp Ser Ser Leu Phe Tyr His Cys 
                325                 330                 335     


Leu Lys Arg Arg Ala Asp Gly Thr Arg His Leu Asp Leu Pro Cys Lys 
            340                 345                 350         


Arg Ser Tyr Leu Glu Ala Pro Ser Ser Val Gly Glu Asp His Tyr Phe 
        355                 360                 365             


Arg Ser Pro Pro Pro Tyr Asp Gln Gln Met Leu Ser Pro Ser Tyr Cys 
    370                 375                 380                 


Ser Glu Val Thr Pro Arg Glu Ala Cys Met Tyr Ser Gly Ser Gly Pro 
385                 390                 395                 400 


Glu Ile Ala Gly Val Ser Gly Val Asp Asp Leu Pro Pro Pro Pro Leu 
                405                 410                 415     


Ser Cys Asn Met Trp Thr Ser Val Ser Pro Tyr Thr Ser Tyr Ser Val 
            420                 425                 430         


Gln Thr Met Glu Thr Val Pro Tyr Gln Pro Phe Pro Thr His Phe Thr 
        435                 440                 445             


Ala Thr Thr Met Met Pro Arg Leu Pro Thr Leu Ser Ala Gln Ser Ser 
    450                 455                 460                 


Gln Pro Pro Gly Asn Ala His Phe Ser Val Tyr Asn Gln Leu Ser Gln 
465                 470                 475                 480 


Ser Gln Val Arg Glu Arg Gly Pro Ser Ala Ser Phe Pro Arg Glu Arg 
                485                 490                 495     


Gly Leu Pro Gln Gly Cys Glu Arg Lys Pro Pro Ser Pro His Leu Asn 
            500                 505                 510         


Ala Ala Asn Glu Phe Leu Tyr Ser Gln Thr Phe Ser Leu Ser Arg Glu 
        515                 520                 525             


Ser Ser Leu Gln Tyr His Ser Gly Met Gly Thr Val Glu Asn Trp Thr 
    530                 535                 540                 


Asp Gly 
545     


<210>  397
<211>  545
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Leu Gln Asp Lys Gly Leu Ser Glu Ser Glu Glu Ala Phe Arg Ala 
1               5                   10                  15      


Pro Gly Pro Ala Leu Gly Glu Ala Ser Ala Ala Asn Ala Pro Glu Pro 
            20                  25                  30          


Ala Leu Ala Ala Pro Gly Leu Ser Gly Ala Ala Leu Gly Ser Pro Pro 
        35                  40                  45              


Gly Pro Gly Ala Asp Val Val Ala Ala Ala Ala Ala Glu Gln Thr Ile 
    50                  55                  60                  


Glu Asn Ile Lys Val Gly Leu His Glu Lys Glu Leu Trp Lys Lys Phe 
65                  70                  75                  80  


His Glu Ala Gly Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met 
                85                  90                  95      


Phe Pro Ser Tyr Lys Val Lys Val Thr Gly Met Asn Pro Lys Thr Lys 
            100                 105                 110         


Tyr Ile Leu Leu Ile Asp Ile Val Pro Ala Asp Asp His Arg Tyr Lys 
        115                 120                 125             


Phe Cys Asp Asn Lys Trp Met Val Ala Gly Lys Ala Glu Pro Ala Met 
    130                 135                 140                 


Pro Gly Arg Leu Tyr Val His Pro Asp Ser Pro Ala Thr Gly Ala His 
145                 150                 155                 160 


Trp Met Arg Gln Leu Val Ser Phe Gln Lys Leu Lys Leu Thr Asn Asn 
                165                 170                 175     


His Leu Asp Pro Phe Gly His Ile Ile Leu Asn Ser Met His Lys Tyr 
            180                 185                 190         


Gln Pro Arg Leu His Ile Val Lys Ala Asp Glu Asn Asn Ala Phe Gly 
        195                 200                 205             


Ser Lys Asn Thr Ala Phe Cys Thr His Val Phe Pro Glu Thr Ser Phe 
    210                 215                 220                 


Ile Ser Val Thr Ser Tyr Gln Asn His Lys Ile Thr Gln Leu Lys Ile 
225                 230                 235                 240 


Glu Asn Asn Pro Phe Ala Lys Gly Phe Arg Gly Ser Asp Asp Ser Asp 
                245                 250                 255     


Leu Arg Val Ala Arg Leu Gln Ser Lys Glu Tyr Pro Val Ile Ser Lys 
            260                 265                 270         


Ser Ile Met Arg Gln Arg Leu Ile Ser Pro Gln Leu Ser Ala Thr Pro 
        275                 280                 285             


Asp Val Gly Pro Leu Leu Gly Thr His Gln Ala Leu Gln His Tyr Gln 
    290                 295                 300                 


His Glu Asn Gly Ala His Ser Gln Leu Ala Glu Pro Gln Asp Leu Pro 
305                 310                 315                 320 


Leu Ser Thr Phe Pro Thr Gln Arg Asp Ser Ser Leu Phe Tyr His Cys 
                325                 330                 335     


Leu Lys Arg Arg Asp Gly Thr Arg His Leu Asp Leu Pro Cys Lys Arg 
            340                 345                 350         


Ser Tyr Leu Glu Ala Pro Ser Ser Val Gly Glu Asp His Tyr Phe Arg 
        355                 360                 365             


Ser Pro Pro Pro Tyr Asp Gln Gln Met Leu Ser Pro Ser Tyr Cys Ser 
    370                 375                 380                 


Glu Val Thr Pro Arg Glu Ala Cys Met Tyr Ser Gly Ser Gly Pro Glu 
385                 390                 395                 400 


Ile Ala Gly Val Ser Gly Val Asp Asp Leu Pro Pro Pro Pro Leu Ser 
                405                 410                 415     


Cys Asn Met Trp Thr Ser Val Ser Pro Tyr Thr Ser Tyr Ser Val Gln 
            420                 425                 430         


Thr Met Glu Thr Val Pro Tyr Gln Pro Phe Pro Thr His Phe Thr Ala 
        435                 440                 445             


Thr Thr Met Met Pro Arg Leu Pro Thr Leu Ser Ala Gln Ser Ser Gln 
    450                 455                 460                 


Pro Pro Gly Asn Ala His Phe Ser Val Tyr Asn Gln Leu Ser Gln Ser 
465                 470                 475                 480 


Gln Val Arg Glu Arg Gly Pro Ser Ala Ser Phe Pro Arg Glu Arg Gly 
                485                 490                 495     


Leu Pro Gln Gly Cys Glu Arg Lys Pro Pro Ser Pro His Leu Asn Ala 
            500                 505                 510         


Ala Asn Glu Phe Leu Tyr Ser Gln Thr Phe Ser Leu Ser Arg Glu Ser 
        515                 520                 525             


Ser Leu Gln Tyr His Ser Gly Met Gly Thr Val Glu Asn Trp Thr Asp 
    530                 535                 540                 


Gly 
545 


<210>  398
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro 
    290                 295                 300                 


Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly 
305                 310                 315                 320 


Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln 
                325                 330                 335     


Gly Leu Gln Cys Glu Arg Glu Gly Ile Pro Arg Met Thr Pro Lys Ile 
            340                 345                 350         


Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro 
        355                 360                 365             


Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr 
    370                 375                 380                 


Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His 
385                 390                 395                 400 


Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro 
                405                 410                 415     


Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met 
            420                 425                 430         


Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu 
        435                 440                 445             


Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn 
    450                 455                 460                 


Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys 
465                 470                 475                 480 


Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln 
                485                 490                 495     


Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu 
            500                 505                 510         


Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly 
        515                 520                 525             


His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro 
    530                 535                 540                 


Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn 
545                 550                 555                 560 


Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val 
                565                 570                 575     


Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys 
            580                 585                 590         


Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg 
        595                 600                 605             


Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu 
    610                 615                 620                 


Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro 
625                 630                 635                 640 


Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val 
                645                 650                 655     


Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile 
            660                 665                 670         


Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys 
        675                 680                 685             


Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro 
    690                 695                 700                 


Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser 
705                 710                 715                 720 


Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln 
                725                 730                 735     


Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
            740                 745                 750         


Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile 
        755                 760                 765             


Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala 
    770                 775                 780                 


Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr 
785                 790                 795                 800 


Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr 
                805                 810                 815     


Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
            820                 825                 830         


Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
        835                 840                 845             


Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
    850                 855                 860                 


Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
865                 870                 875                 880 


His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
                885                 890                 895     


Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
            900                 905                 910         


Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
        915                 920                 925             


Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
    930                 935                 940                 


Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
945                 950                 955                 960 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
                965                 970                 975     


Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
            980                 985                 990         


Val Lys Lys Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
        995                 1000                 1005             


Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Asn Ser Asp  Val Trp Ser 
    1010                 1015                 1020             


Tyr Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1025                 1030                 1035             


Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1040                 1045                 1050             


Gly Tyr  Arg Leu Glu Lys Pro  Leu Asn Cys Asp Asp  Glu Val Tyr 
    1055                 1060                 1065             


Asp Leu  Met Arg Gln Cys Trp  Arg Glu Lys Pro Tyr  Glu Arg Pro 
    1070                 1075                 1080             


Ser Phe  Ala Gln Ile Leu Val  Ser Leu Asn Arg Met  Leu Glu Glu 
    1085                 1090                 1095             


Arg Lys  Thr Tyr Val Asn Thr  Thr Leu Tyr Glu Lys  Phe Thr Tyr 
    1100                 1105                 1110             


Ala Gly  Ile Asp Cys Ser Ala  Glu Glu Ala Ala 
    1115                 1120                 


<210>  399
<211>  1081
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Gly Ile Pro Arg 
    290                 295                 300                 


Met Thr Pro Lys Ile Val Asp Leu Pro Asp His Ile Glu Val Asn Ser 
305                 310                 315                 320 


Gly Lys Phe Asn Pro Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr 
                325                 330                 335     


Asn Glu Glu Met Thr Leu Val Lys Pro Asp Gly Thr Val Leu His Pro 
            340                 345                 350         


Lys Asp Phe Asn His Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile 
        355                 360                 365             


His Arg Ile Leu Pro Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn 
    370                 375                 380                 


Thr Val Ala Gly Met Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val 
385                 390                 395                 400 


Leu Pro Lys Pro Leu Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn 
                405                 410                 415     


Phe Ala Val Ile Asn Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro 
            420                 425                 430         


Ile Lys Ser Lys Lys Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala 
        435                 440                 445             


Trp Gln His Ile Gln Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu 
    450                 455                 460                 


Glu Pro Arg Thr Glu Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly 
465                 470                 475                 480 


Glu Gly Gly Glu Gly His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala 
                485                 490                 495     


Ser Ile Gly Leu Pro Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser 
            500                 505                 510         


Gln Thr Thr Leu Asn Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu 
        515                 520                 525             


Asp Asp Phe Tyr Val Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp 
    530                 535                 540                 


Gln Gln Asn Ile Lys Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn 
545                 550                 555                 560 


Asn Leu His Pro Arg Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr 
                565                 570                 575     


Lys Ala Gln Gly Glu Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser 
            580                 585                 590         


Asp Ile Leu Pro Pro Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr 
        595                 600                 605             


His Ser Ser Ala Val Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile 
    610                 615                 620                 


Ser Ser Ile Thr Ile Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln 
625                 630                 635                 640 


His Val Asp Val Lys Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu 
                645                 650                 655     


Lys Gly Leu Glu Pro Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu 
            660                 665                 670         


Asn Asn Ile Gly Ser Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr 
        675                 680                 685             


Leu Pro Glu Ser Gln Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu 
    690                 695                 700                 


Leu Ile Ala Ile Leu Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu 
705                 710                 715                 720 


Leu Ala Phe Leu Ile Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg 
                725                 730                 735     


Arg Met Ala Gln Ala Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln 
            740                 745                 750         


Phe Asn Ser Gly Thr Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro 
        755                 760                 765             


Asp Pro Thr Ile Tyr Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln 
    770                 775                 780                 


Asp Val Ile Gly Glu Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile 
785                 790                 795                 800 


Lys Lys Asp Gly Leu Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu 
                805                 810                 815     


Tyr Ala Ser Lys Asp Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val 
            820                 825                 830         


Leu Cys Lys Leu Gly His His Pro Asn Ile Ile Asn Leu Leu Gly Ala 
        835                 840                 845             


Cys Glu His Arg Gly Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His 
    850                 855                 860                 


Gly Asn Leu Leu Asp Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp 
865                 870                 875                 880 


Pro Ala Phe Ala Ile Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln 
                885                 890                 895     


Gln Leu Leu His Phe Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu 
            900                 905                 910         


Ser Gln Lys Gln Phe Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu 
        915                 920                 925             


Val Gly Glu Asn Tyr Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg 
    930                 935                 940                 


Gly Gln Glu Val Tyr Val Lys Lys Thr Met Gly Arg Leu Pro Val Arg 
945                 950                 955                 960 


Trp Met Ala Ile Glu Ser Leu Asn Tyr Ser Val Tyr Thr Thr Asn Ser 
                965                 970                 975     


Asp Val Trp Ser Tyr Gly Val Leu Leu Trp Glu Ile Val Ser Leu Gly 
            980                 985                 990         


Gly Thr Pro Tyr Cys Gly Met Thr  Cys Ala Glu Leu Tyr  Glu Lys Leu 
        995                 1000                 1005             


Pro Gln  Gly Tyr Arg Leu Glu  Lys Pro Leu Asn Cys  Asp Asp Glu 
    1010                 1015                 1020             


Val Tyr  Asp Leu Met Arg Gln  Cys Trp Arg Glu Lys  Pro Tyr Glu 
    1025                 1030                 1035             


Arg Pro  Ser Phe Ala Gln Ile  Leu Val Ser Leu Asn  Arg Met Leu 
    1040                 1045                 1050             


Glu Glu  Arg Lys Thr Tyr Val  Asn Thr Thr Leu Tyr  Glu Lys Phe 
    1055                 1060                 1065             


Thr Tyr  Ala Gly Ile Asp Cys  Ser Ala Glu Glu Ala  Ala 
    1070                 1075                 1080     


<210>  400
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Ala Ser Phe Leu Pro Ala Thr Leu Thr Met Thr Val Asp Lys Gly 
            20                  25                  30          


Asp Asn Val Asn Ile Ser Phe Lys Lys Val Leu Ile Lys Glu Glu Asp 
        35                  40                  45              


Ala Val Ile Tyr Lys Asn Gly Ser Phe Ile His Ser Val Pro Arg His 
    50                  55                  60                  


Glu Val Pro Asp Ile Leu Glu Val His Leu Pro His Ala Gln Pro Gln 
65                  70                  75                  80  


Asp Ala Gly Val Tyr Ser Ala Arg Tyr Ile Gly Gly Asn Leu Phe Thr 
                85                  90                  95      


Ser Ala Phe Thr Arg Leu Ile Val Arg Arg Cys Glu Ala Gln Lys Trp 
            100                 105                 110         


Gly Pro Glu Cys Asn His Leu Cys Thr Ala Cys Met Asn Asn Gly Val 
        115                 120                 125             


Cys His Glu Asp Thr Gly Glu Cys Ile Cys Pro Pro Gly Phe Met Gly 
    130                 135                 140                 


Arg Thr Cys Glu Lys Ala Cys Glu Leu His Thr Phe Gly Arg Thr Cys 
145                 150                 155                 160 


Lys Glu Arg Cys Ser Gly Gln Glu Gly Cys Lys Ser Tyr Val Phe Cys 
                165                 170                 175     


Leu Pro Asp Pro Tyr Gly Cys Ser Cys Ala Thr Gly Trp Lys Gly Leu 
            180                 185                 190         


Gln Cys Asn Glu Gly Ile Pro Arg Met Thr Pro Lys Ile Val Asp Leu 
        195                 200                 205             


Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro Ile Cys Lys 
    210                 215                 220                 


Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr Leu Val Lys 
225                 230                 235                 240 


Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His Thr Asp His 
                245                 250                 255     


Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro Pro Asp Ser 
            260                 265                 270         


Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met Val Glu Lys 
        275                 280                 285             


Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu Asn Ala Pro 
    290                 295                 300                 


Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn Ile Ser Ser 
305                 310                 315                 320 


Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys Leu Leu Tyr 
                325                 330                 335     


Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln Val Thr Asn 
            340                 345                 350         


Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu Tyr Glu Leu 
        355                 360                 365             


Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly His Pro Gly 
    370                 375                 380                 


Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro Pro Pro Arg 
385                 390                 395                 400 


Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn Leu Thr Trp 
                405                 410                 415     


Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val Glu Val Glu 
            420                 425                 430         


Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys Val Pro Gly 
        435                 440                 445             


Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg Glu Gln Tyr 
    450                 455                 460                 


Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu Trp Ser Glu 
465                 470                 475                 480 


Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro Gln Pro Glu 
                485                 490                 495     


Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val Ile Ser Trp 
            500                 505                 510         


Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile Arg Tyr Lys 
        515                 520                 525             


Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys Ile Lys Asn 
    530                 535                 540                 


Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro Glu Thr Ala 
545                 550                 555                 560 


Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser Ser Asn Pro 
                565                 570                 575     


Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln Ala Pro Ala 
            580                 585                 590         


Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu Gly Ser Ala 
        595                 600                 605             


Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile Ile Leu Gln 
    610                 615                 620                 


Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala Phe Gln Asn 
625                 630                 635                 640 


Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr Leu Ala Leu Asn 
                645                 650                 655     


Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr Pro Val Leu Asp 
            660                 665                 670         


Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu Gly Asn Phe Gly 
        675                 680                 685             


Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu Arg Met Asp Ala 
    690                 695                 700                 


Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp Asp His Arg Asp 
705                 710                 715                 720 


Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His His Pro Asn 
                725                 730                 735     


Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly Tyr Leu Tyr Leu 
            740                 745                 750         


Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp Phe Leu Arg Lys 
        755                 760                 765             


Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile Ala Asn Ser Thr 
    770                 775                 780                 


Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe Ala Ala Asp Val 
785                 790                 795                 800 


Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe Ile His Arg Asp 
                805                 810                 815     


Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr Val Ala Lys Ile 
            820                 825                 830         


Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr Val Lys Lys Thr 
        835                 840                 845             


Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu Ser Leu Asn Tyr 
    850                 855                 860                 


Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr Gly Val Leu Leu 
865                 870                 875                 880 


Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys Gly Met Thr Cys 
                885                 890                 895     


Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg Leu Glu Lys Pro 
            900                 905                 910         


Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg Gln Cys Trp Arg 
        915                 920                 925             


Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile Leu Val Ser Leu 
    930                 935                 940                 


Asn Arg Met Leu Glu Glu Arg Lys Thr Tyr Val Asn Thr Thr Leu Tyr 
945                 950                 955                 960 


Glu Lys Phe Thr Tyr Ala Gly Ile Asp Cys Ser Ala Glu Glu Ala Ala 
                965                 970                 975     


<210>  401
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  402
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         


Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             


Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 


Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 


Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     


Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         


Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 
        995                 1000                 1005             


Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 
    1010                 1015                 1020             


Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 
    1025                 1030                 1035             


Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 
    1040                 1045                 1050             


Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp 
    


<210>  403
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  404
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  405
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 
                325                 330                 335     


Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            340                 345     


<210>  406
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  407
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  408
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  409
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
                325                 330                 335     


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
            340                 345                 350         


Ser Asp 
        


<210>  410
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 
    290                 295                 300                 


Asn Ser Ser 
305         


<210>  411
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 
    290                 295                 300         


<210>  412
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 
1               5                   10                  15      


Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 
            20                  25                  30          


Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 
        35                  40                  45              


Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
    50                  55                  60                  


Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 
65                  70                  75                  80  


Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
                85                  90                  95      


Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 
            100                 105                 110         


Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 
        115                 120                 125             


Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
    130                 135                 140                 


Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
                165                 170                 175     


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
            180                 185                 190         


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser 
        195                 200                 205             


His Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu 
    210                 215                 220                 


Met Phe Lys Thr Glu Gly Pro Asp Ser Asp 
225                 230                 


<210>  413
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 
1               5                   10                  15      


Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 
            20                  25                  30          


Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 
        35                  40                  45              


Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
    50                  55                  60                  


Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 
65                  70                  75                  80  


Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
                85                  90                  95      


Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 
            100                 105                 110         


Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 
        115                 120                 125             


Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
    130                 135                 140                 


Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser 
                165                 170                 175     


Phe Gln Lys Glu Asn Cys 
            180         


<210>  414
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 
1               5                   10                  15      


Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 
            20                  25                  30          


Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 
        35                  40                  45              


Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
    50                  55                  60                  


Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 
65                  70                  75                  80  


Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
                85                  90                  95      


Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 
            100                 105                 110         


Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 
        115                 120                 125             


Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
    130                 135                 140                 


Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp 
                165                 170                 175     


Leu Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            180                 185         


<210>  415
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Leu His Ser Phe Thr Asp 
385                 390                 395                 400 


Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp Ala 
                405                 410                 415     


Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn Met 
            420                 425                 430         


Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr Ser 
        435                 440                 445             


Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val Glu 
    450                 455                 460                 


Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr Leu 
465                 470                 475                 480 


Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr Arg 
                485                 490                 495     


Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser Ser 
            500                 505                 510         


Lys Arg Tyr Thr Glu Glu Ala 
        515                 


<210>  416
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Ser Pro Leu Trp Trp Gly Phe Leu Leu Ser Cys Leu Gly Cys Lys 
1               5                   10                  15      


Ile Leu Pro Gly Ala Gln Gly Gln Phe Pro Arg Val Cys Met Thr Val 
            20                  25                  30          


Asp Ser Leu Val Asn Lys Glu Cys Cys Pro Arg Leu Gly Ala Glu Ser 
        35                  40                  45              


Ala Asn Val Cys Gly Ser Gln Gln Gly Arg Gly Gln Cys Thr Glu Val 
    50                  55                  60                  


Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro Tyr Ile Leu Arg Asn Gln 
65                  70                  75                  80  


Asp Asp Arg Glu Leu Trp Pro Arg Lys Phe Phe His Arg Thr Cys Lys 
                85                  90                  95      


Cys Thr Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe Gly 
            100                 105                 110         


Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg Gln 
        115                 120                 125             


Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly Ala 
    130                 135                 140                 


Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr Thr 
145                 150                 155                 160 


Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln Phe 
                165                 170                 175     


Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr Ser 
            180                 185                 190         


Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile Asp 
        195                 200                 205             


Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His Leu 
    210                 215                 220                 


Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser Phe 
225                 230                 235                 240 


Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp Val 
                245                 250                 255     


Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr Leu 
            260                 265                 270         


Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp Ser 
        275                 280                 285             


Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr Glu 
    290                 295                 300                 


Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu Pro 
305                 310                 315                 320 


Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp Asn 
                325                 330                 335     


Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu Glu 
            340                 345                 350         


Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser Leu 
        355                 360                 365             


His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro His 
    370                 375                 380                 


Ser Ala Ala Asn Asp Pro Ile Phe Val Val Ile Ser Asn Arg Leu Leu 
385                 390                 395                 400 


Tyr Asn Ala Thr Thr Asn Ile Leu Glu His Val Arg Lys Glu Lys Ala 
                405                 410                 415     


Thr Lys Glu Leu Pro Ser Leu His Val Leu Val Leu His Ser Phe Thr 
            420                 425                 430         


Asp Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp 
        435                 440                 445             


Ala Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn 
    450                 455                 460                 


Met Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr 
465                 470                 475                 480 


Ser Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val 
                485                 490                 495     


Glu Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr 
            500                 505                 510         


Leu Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr 
        515                 520                 525             


Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser 
    530                 535                 540                 


Ser Lys Arg Tyr Thr Glu Glu Ala 
545                 550         


<210>  417
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Gly Arg Asn Ser Met Lys Leu Pro Thr Leu Lys Asp Ile Arg Asp 
1               5                   10                  15      


Cys Leu Ser Leu Gln Lys Phe Asp Asn Pro Pro Phe Phe Gln Asn Ser 
            20                  25                  30          


Thr Phe Ser Phe Arg Asn Ala Leu Glu Gly Phe Asp Lys Ala Asp Gly 
        35                  40                  45              


Thr Leu Asp Ser Gln Val Met Ser Leu His Asn Leu Val His Ser Phe 
    50                  55                  60                  


Leu Asn Gly Thr Asn Ala Leu Pro His Ser Ala Ala Asn Asp Pro Ile 
65                  70                  75                  80  


Phe Val Val Leu His Ser Phe Thr Asp Ala Ile Phe Asp Glu Trp Met 
                85                  90                  95      


Lys Arg Phe Asn Pro Pro Ala Asp Ala Trp Pro Gln Glu Leu Ala Pro 
            100                 105                 110         


Ile Gly His Asn Arg Met Tyr Asn Met Val Pro Phe Phe Pro Pro Val 
        115                 120                 125             


Thr Asn Glu Glu Leu Phe Leu Thr Ser Asp Gln Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Ala Ile Asp Leu Pro Val Ser Val Glu Glu Thr Pro Gly Trp Pro Thr 
145                 150                 155                 160 


Thr Leu Leu Val Val Met Gly Thr Leu Val Ala Leu Val Gly Leu Phe 
                165                 170                 175     


Val Leu Leu Ala Phe Leu Gln Tyr Arg Arg Leu Arg Lys Gly Tyr Thr 
            180                 185                 190         


Pro Leu Met Glu Thr His Leu Ser Ser Lys Arg Tyr Thr Glu Glu Ala 
        195                 200                 205             


<210>  418
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Leu Leu Gly Ile Gln Arg Gln Met Lys Cys Arg Leu Arg Ser Asp 
1               5                   10                  15      


Val Thr Lys Arg Leu Glu Glu Asp Glu His Val Asn Thr His Ser Pro 
            20                  25                  30          


Met Arg Arg Gly Asn Phe Ala Gly Tyr Asn Cys Gly Asp Cys Lys Phe 
        35                  40                  45              


Gly Trp Thr Gly Pro Asn Cys Glu Arg Lys Lys Pro Pro Val Ile Arg 
    50                  55                  60                  


Gln Asn Ile His Ser Leu Ser Pro Gln Glu Arg Glu Gln Phe Leu Gly 
65                  70                  75                  80  


Ala Leu Asp Leu Ala Lys Lys Arg Val His Pro Asp Tyr Val Ile Thr 
                85                  90                  95      


Thr Gln His Trp Leu Gly Leu Leu Gly Pro Asn Gly Thr Gln Pro Gln 
            100                 105                 110         


Phe Ala Asn Cys Ser Val Tyr Asp Phe Phe Val Trp Leu His Tyr Tyr 
        115                 120                 125             


Ser Val Arg Asp Thr Leu Leu Gly Pro Gly Arg Pro Tyr Arg Ala Ile 
    130                 135                 140                 


Asp Phe Ser His Gln Gly Pro Ala Phe Val Thr Trp His Arg Tyr His 
145                 150                 155                 160 


Leu Leu Cys Leu Glu Arg Asp Leu Gln Arg Leu Ile Gly Asn Glu Ser 
                165                 170                 175     


Phe Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly Arg Asn Glu Cys Asp 
            180                 185                 190         


Val Cys Thr Asp Gln Leu Phe Gly Ala Ala Arg Pro Asp Asp Pro Thr 
        195                 200                 205             


Leu Ile Ser Arg Asn Ser Arg Phe Ser Ser Trp Glu Thr Val Cys Asp 
    210                 215                 220                 


Ser Leu Asp Asp Tyr Asn His Leu Val Thr Leu Cys Asn Gly Thr Tyr 
225                 230                 235                 240 


Glu Gly Leu Leu Arg Arg Asn Gln Met Gly Arg Asn Ser Met Lys Leu 
                245                 250                 255     


Pro Thr Leu Lys Asp Ile Arg Asp Cys Leu Ser Leu Gln Lys Phe Asp 
            260                 265                 270         


Asn Pro Pro Phe Phe Gln Asn Ser Thr Phe Ser Phe Arg Asn Ala Leu 
        275                 280                 285             


Glu Gly Phe Asp Lys Ala Asp Gly Thr Leu Asp Ser Gln Val Met Ser 
    290                 295                 300                 


Leu His Asn Leu Val His Ser Phe Leu Asn Gly Thr Asn Ala Leu Pro 
305                 310                 315                 320 


His Ser Ala Ala Asn Asp Pro Ile Phe Val Val Leu His Ser Phe Thr 
                325                 330                 335     


Asp Ala Ile Phe Asp Glu Trp Met Lys Arg Phe Asn Pro Pro Ala Asp 
            340                 345                 350         


Ala Trp Pro Gln Glu Leu Ala Pro Ile Gly His Asn Arg Met Tyr Asn 
        355                 360                 365             


Met Val Pro Phe Phe Pro Pro Val Thr Asn Glu Glu Leu Phe Leu Thr 
    370                 375                 380                 


Ser Asp Gln Leu Gly Tyr Ser Tyr Ala Ile Asp Leu Pro Val Ser Val 
385                 390                 395                 400 


Glu Glu Thr Pro Gly Trp Pro Thr Thr Leu Leu Val Val Met Gly Thr 
                405                 410                 415     


Leu Val Ala Leu Val Gly Leu Phe Val Leu Leu Ala Phe Leu Gln Tyr 
            420                 425                 430         


Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr His Leu Ser 
        435                 440                 445             


Ser Lys Arg Tyr Thr Glu Glu Ala 
    450                 455     


<210>  419
<211>  3859
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr 
1               5                   10                  15      


Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn 
            20                  25                  30          


Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn 
        35                  40                  45              


Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His 
    50                  55                  60                  


Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile 
                85                  90                  95      


Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn 
            100                 105                 110         


Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn 
        115                 120                 125             


Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg 
    130                 135                 140                 


Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln 
145                 150                 155                 160 


Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro 
                165                 170                 175     


Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met 
            180                 185                 190         


Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu 
        195                 200                 205             


Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val 
    210                 215                 220                 


Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys 
225                 230                 235                 240 


Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn 
                245                 250                 255     


Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr 
            260                 265                 270         


Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu 
        275                 280                 285             


Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys 
    290                 295                 300                 


Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys 
305                 310                 315                 320 


Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys 
                325                 330                 335     


His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp 
            340                 345                 350         


Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg 
        355                 360                 365             


Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His 
    370                 375                 380                 


His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln 
385                 390                 395                 400 


Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln 
                405                 410                 415     


Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser 
            420                 425                 430         


Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met 
        435                 440                 445             


Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu 
    450                 455                 460                 


Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val 
465                 470                 475                 480 


Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro 
                485                 490                 495     


Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu 
        515                 520                 525             


Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr 
    530                 535                 540                 


Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile 
545                 550                 555                 560 


Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile 
                565                 570                 575     


Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu 
            580                 585                 590         


Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala 
        595                 600                 605             


Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg 
    610                 615                 620                 


Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr 
625                 630                 635                 640 


Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro 
                645                 650                 655     


Tyr Met Val Glu Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala 
            660                 665                 670         


Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile 
        675                 680                 685             


Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val 
    690                 695                 700                 


Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser 
705                 710                 715                 720 


Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu 
                725                 730                 735     


His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu 
            740                 745                 750         


Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly 
        755                 760                 765             


Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro 
    770                 775                 780                 


Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln 
785                 790                 795                 800 


His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg 
                805                 810                 815     


Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val 
            820                 825                 830         


Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr 
        835                 840                 845             


Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His 
    850                 855                 860                 


Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu 
865                 870                 875                 880 


Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly 
                885                 890                 895     


Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu 
            900                 905                 910         


His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe 
        915                 920                 925             


Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu 
    930                 935                 940                 


Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg 
945                 950                 955                 960 


Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser 
                965                 970                 975     


Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn 
            980                 985                 990         


Phe Thr Glu Lys Thr Ile Pro Asn  Val Ile Ile Ser His  Arg Tyr Lys 
        995                 1000                 1005             


Ala Gln  Asp Thr Pro Ala Arg  Lys Thr Phe Glu Gln  Ala Leu Thr 
    1010                 1015                 1020             


Gly Ala  Phe Met Ser Ala Val  Ile Lys Asp Leu Arg  Pro Ser Ala 
    1025                 1030                 1035             


Leu Pro  Phe Val Ala Ser Leu  Ile Arg His Tyr Thr  Met Val Ala 
    1040                 1045                 1050             


Val Ala  Gln Gln Cys Gly Pro  Phe Leu Leu Pro Cys  Tyr Gln Val 
    1055                 1060                 1065             


Gly Ser  Gln Pro Ser Thr Ala  Met Phe His Ser Glu  Glu Asn Gly 
    1070                 1075                 1080             


Ser Lys  Gly Met Asp Pro Leu  Val Leu Ile Asp Ala  Ile Ala Ile 
    1085                 1090                 1095             


Cys Met  Ala Tyr Glu Glu Lys  Glu Leu Cys Lys Ile  Gly Glu Val 
    1100                 1105                 1110             


Ala Leu  Ala Val Ile Phe Asp  Val Ala Ser Ile Ile  Leu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Arg Ala Cys Gln Leu  Pro Leu Phe Ser Tyr  Ile Val Glu 
    1130                 1135                 1140             


Arg Leu  Cys Ala Cys Cys Tyr  Glu Gln Ala Trp Tyr  Ala Lys Leu 
    1145                 1150                 1155             


Gly Gly  Val Val Ser Ile Lys  Phe Leu Met Glu Arg  Leu Pro Leu 
    1160                 1165                 1170             


Thr Trp  Val Leu Gln Asn Gln  Gln Thr Phe Leu Lys  Ala Leu Leu 
    1175                 1180                 1185             


Phe Val  Met Met Asp Leu Thr  Gly Glu Val Ser Asn  Gly Ala Val 
    1190                 1195                 1200             


Ala Met  Ala Lys Thr Thr Leu  Glu Gln Leu Leu Met  Arg Cys Ala 
    1205                 1210                 1215             


Thr Pro  Leu Lys Asp Glu Glu  Arg Ala Glu Glu Ile  Val Ala Ala 
    1220                 1225                 1230             


Gln Glu  Lys Ser Phe His His  Val Thr His Asp Leu  Val Arg Glu 
    1235                 1240                 1245             


Val Thr  Ser Pro Asn Ser Thr  Val Arg Lys Gln Ala  Met His Ser 
    1250                 1255                 1260             


Leu Gln  Val Leu Ala Gln Val  Thr Gly Lys Ser Val  Thr Val Ile 
    1265                 1270                 1275             


Met Glu  Pro His Lys Glu Val  Leu Gln Asp Met Val  Pro Pro Lys 
    1280                 1285                 1290             


Lys His  Leu Leu Arg His Gln  Pro Ala Asn Ala Gln  Ile Gly Leu 
    1295                 1300                 1305             


Met Glu  Gly Asn Thr Phe Cys  Thr Thr Leu Gln Pro  Arg Leu Phe 
    1310                 1315                 1320             


Thr Met  Asp Leu Asn Val Val  Glu His Lys Val Phe  Tyr Thr Glu 
    1325                 1330                 1335             


Leu Leu  Asn Leu Cys Glu Ala  Glu Asp Ser Ala Leu  Thr Lys Leu 
    1340                 1345                 1350             


Pro Cys  Tyr Lys Ser Leu Pro  Ser Leu Val Pro Leu  Arg Ile Ala 
    1355                 1360                 1365             


Ala Leu  Asn Ala Leu Ala Ala  Cys Asn Tyr Leu Pro  Gln Ser Arg 
    1370                 1375                 1380             


Glu Lys  Ile Ile Ala Ala Leu  Phe Lys Ala Leu Asn  Ser Thr Asn 
    1385                 1390                 1395             


Ser Glu  Leu Gln Glu Ala Gly  Glu Ala Cys Met Arg  Lys Phe Leu 
    1400                 1405                 1410             


Glu Gly  Ala Thr Ile Glu Val  Asp Gln Ile His Thr  His Met Arg 
    1415                 1420                 1425             


Pro Leu  Leu Met Met Leu Gly  Asp Tyr Arg Ser Leu  Thr Leu Asn 
    1430                 1435                 1440             


Val Val  Asn Arg Leu Thr Ser  Val Thr Arg Leu Phe  Pro Asn Ser 
    1445                 1450                 1455             


Phe Asn  Asp Lys Phe Cys Asp  Gln Met Met Gln His  Leu Arg Lys 
    1460                 1465                 1470             


Trp Met  Glu Val Val Val Ile  Thr His Lys Gly Gly  Gln Arg Ser 
    1475                 1480                 1485             


Asp Gly  Asn Glu Ser Ile Ser  Glu Cys Gly Arg Cys  Pro Leu Ser 
    1490                 1495                 1500             


Pro Phe  Cys Gln Phe Glu Glu  Met Lys Ile Cys Ser  Ala Ile Ile 
    1505                 1510                 1515             


Asn Leu  Phe His Leu Ile Pro  Ala Ala Pro Gln Thr  Leu Val Lys 
    1520                 1525                 1530             


Pro Leu  Leu Glu Val Val Met  Lys Thr Glu Arg Ala  Met Leu Ile 
    1535                 1540                 1545             


Glu Ala  Gly Ser Pro Phe Arg  Glu Pro Leu Ile Lys  Phe Leu Thr 
    1550                 1555                 1560             


Arg His  Pro Ser Gln Thr Val  Glu Leu Phe Met Met  Glu Ala Thr 
    1565                 1570                 1575             


Leu Asn  Asp Pro Gln Trp Ser  Arg Met Phe Met Ser  Phe Leu Lys 
    1580                 1585                 1590             


His Lys  Asp Ala Arg Pro Leu  Arg Asp Val Leu Ala  Ala Asn Pro 
    1595                 1600                 1605             


Asn Arg  Phe Ile Thr Leu Leu  Leu Pro Gly Gly Ala  Gln Thr Ala 
    1610                 1615                 1620             


Val Arg  Pro Gly Ser Pro Ser  Thr Ser Thr Met Arg  Leu Asp Leu 
    1625                 1630                 1635             


Gln Phe  Gln Ala Ile Lys Ile  Ile Ser Ile Ile Val  Lys Asn Asp 
    1640                 1645                 1650             


Asp Ser  Trp Leu Ala Ser Gln  His Ser Leu Val Ser  Gln Leu Arg 
    1655                 1660                 1665             


Arg Val  Trp Val Ser Glu Asn  Phe Gln Glu Arg His  Arg Lys Glu 
    1670                 1675                 1680             


Asn Met  Ala Ala Thr Asn Trp  Lys Glu Pro Lys Leu  Leu Ala Tyr 
    1685                 1690                 1695             


Cys Leu  Leu Asn Tyr Cys Lys  Arg Asn Tyr Gly Asp  Ile Glu Leu 
    1700                 1705                 1710             


Leu Phe  Gln Leu Leu Arg Ala  Phe Thr Gly Arg Phe  Leu Cys Asn 
    1715                 1720                 1725             


Met Thr  Phe Leu Lys Glu Tyr  Met Glu Glu Glu Ile  Pro Lys Asn 
    1730                 1735                 1740             


Tyr Ser  Ile Ala Gln Lys Arg  Ala Leu Phe Phe Arg  Phe Val Asp 
    1745                 1750                 1755             


Phe Asn  Asp Pro Asn Phe Gly  Asp Glu Leu Lys Ala  Lys Val Leu 
    1760                 1765                 1770             


Gln His  Ile Leu Asn Pro Ala  Phe Leu Tyr Ser Phe  Glu Lys Gly 
    1775                 1780                 1785             


Glu Gly  Glu Gln Leu Leu Gly  Pro Pro Asn Pro Glu  Gly Asp Asn 
    1790                 1795                 1800             


Pro Glu  Ser Ile Thr Ser Val  Phe Ile Thr Lys Val  Leu Asp Pro 
    1805                 1810                 1815             


Glu Lys  Gln Ala Asp Met Leu  Asp Ser Leu Arg Ile  Tyr Leu Leu 
    1820                 1825                 1830             


Gln Tyr  Ala Thr Leu Leu Val  Glu His Ala Pro His  His Ile His 
    1835                 1840                 1845             


Asp Asn  Asn Lys Asn Arg Asn  Ser Lys Leu Arg Arg  Leu Met Thr 
    1850                 1855                 1860             


Phe Ala  Trp Pro Cys Leu Leu  Ser Lys Ala Cys Val  Asp Pro Ala 
    1865                 1870                 1875             


Cys Lys  Tyr Ser Gly His Leu  Leu Leu Ala His Ile  Ile Ala Lys 
    1880                 1885                 1890             


Phe Ala  Ile His Lys Lys Ile  Val Leu Gln Val Phe  His Ser Leu 
    1895                 1900                 1905             


Leu Lys  Ala His Ala Met Glu  Ala Arg Ala Ile Val  Arg Gln Ala 
    1910                 1915                 1920             


Met Ala  Ile Leu Thr Pro Ala  Val Pro Ala Arg Met  Glu Asp Gly 
    1925                 1930                 1935             


His Gln  Met Leu Thr His Trp  Thr Arg Lys Ile Ile  Val Glu Glu 
    1940                 1945                 1950             


Gly His  Thr Val Pro Gln Leu  Val His Ile Leu His  Leu Ile Val 
    1955                 1960                 1965             


Gln His  Phe Lys Val Tyr Tyr  Pro Val Arg His His  Leu Val Gln 
    1970                 1975                 1980             


His Met  Val Ser Ala Met Gln  Arg Leu Gly Phe Thr  Pro Ser Val 
    1985                 1990                 1995             


Thr Ile  Glu Gln Arg Arg Leu  Ala Val Asp Leu Ser  Glu Val Val 
    2000                 2005                 2010             


Ile Lys  Trp Glu Leu Gln Arg  Ile Lys Asp Gln Gln  Pro Asp Ser 
    2015                 2020                 2025             


Asp Met  Asp Pro Asn Ser Ser  Gly Glu Gly Val Asn  Ser Val Ser 
    2030                 2035                 2040             


Ser Ser  Ile Lys Arg Gly Leu  Ser Val Asp Ser Ala  Gln Glu Val 
    2045                 2050                 2055             


Lys Arg  Phe Arg Thr Ala Thr  Gly Ala Ile Ser Ala  Val Phe Gly 
    2060                 2065                 2070             


Arg Ser  Gln Ser Leu Pro Gly  Ala Asp Ser Leu Leu  Ala Lys Pro 
    2075                 2080                 2085             


Ile Asp  Lys Gln His Thr Asp  Thr Val Val Asn Phe  Leu Ile Arg 
    2090                 2095                 2100             


Val Ala  Cys Gln Val Asn Asp  Asn Thr Asn Thr Ala  Gly Ser Pro 
    2105                 2110                 2115             


Gly Glu  Val Leu Ser Arg Arg  Cys Val Asn Leu Leu  Lys Thr Ala 
    2120                 2125                 2130             


Leu Arg  Pro Asp Met Trp Pro  Lys Ser Glu Leu Lys  Leu Gln Trp 
    2135                 2140                 2145             


Phe Asp  Lys Leu Leu Met Thr  Val Glu Gln Pro Asn  Gln Val Asn 
    2150                 2155                 2160             


Tyr Gly  Asn Ile Cys Thr Gly  Leu Glu Val Leu Ser  Phe Leu Leu 
    2165                 2170                 2175             


Thr Val  Leu Gln Ser Pro Ala  Ile Leu Ser Ser Phe  Lys Pro Leu 
    2180                 2185                 2190             


Gln Arg  Gly Ile Ala Ala Cys  Met Thr Cys Gly Asn  Thr Lys Val 
    2195                 2200                 2205             


Leu Arg  Ala Val His Ser Leu  Leu Ser Arg Leu Met  Ser Ile Phe 
    2210                 2215                 2220             


Pro Thr  Glu Pro Ser Thr Ser  Ser Val Ala Ser Lys  Tyr Glu Glu 
    2225                 2230                 2235             


Leu Glu  Cys Leu Tyr Ala Ala  Val Gly Lys Val Ile  Tyr Glu Gly 
    2240                 2245                 2250             


Leu Thr  Asn Tyr Glu Lys Ala  Thr Asn Ala Asn Pro  Ser Gln Leu 
    2255                 2260                 2265             


Phe Gly  Thr Leu Met Ile Leu  Lys Ser Ala Cys Ser  Asn Asn Pro 
    2270                 2275                 2280             


Ser Tyr  Ile Asp Arg Leu Ile  Ser Val Phe Met Arg  Ser Leu Gln 
    2285                 2290                 2295             


Lys Met  Val Arg Glu His Leu  Asn Pro Gln Ala Ala  Ser Gly Ser 
    2300                 2305                 2310             


Thr Glu  Ala Thr Ser Gly Thr  Ser Glu Leu Val Met  Leu Ser Leu 
    2315                 2320                 2325             


Glu Leu  Val Lys Thr Arg Leu  Ala Val Met Ser Met  Glu Met Arg 
    2330                 2335                 2340             


Lys Asn  Phe Ile Gln Ala Ile  Leu Thr Ser Leu Ile  Glu Lys Ser 
    2345                 2350                 2355             


Pro Asp  Ala Lys Ile Leu Arg  Ala Val Val Lys Ile  Val Glu Glu 
    2360                 2365                 2370             


Trp Val  Lys Asn Asn Ser Pro  Met Ala Ala Asn Gln  Thr Pro Thr 
    2375                 2380                 2385             


Leu Arg  Glu Lys Ser Ile Leu  Leu Val Lys Met Met  Thr Tyr Ile 
    2390                 2395                 2400             


Glu Lys  Arg Phe Pro Glu Asp  Leu Glu Leu Asn Ala  Gln Phe Leu 
    2405                 2410                 2415             


Asp Leu  Val Asn Tyr Val Tyr  Arg Asp Glu Thr Leu  Ser Gly Ser 
    2420                 2425                 2430             


Glu Leu  Thr Ala Lys Leu Glu  Pro Ala Phe Leu Ser  Gly Leu Arg 
    2435                 2440                 2445             


Cys Ala  Gln Pro Leu Ile Arg  Ala Lys Phe Phe Glu  Val Phe Asp 
    2450                 2455                 2460             


Asn Ser  Met Lys Arg Arg Val  Tyr Glu Arg Leu Leu  Tyr Val Thr 
    2465                 2470                 2475             


Cys Ser  Gln Asn Trp Glu Ala  Met Gly Asn His Phe  Trp Ile Lys 
    2480                 2485                 2490             


Gln Cys  Ile Glu Leu Leu Leu  Ala Val Cys Glu Lys  Ser Thr Pro 
    2495                 2500                 2505             


Ile Gly  Thr Ser Cys Gln Gly  Ala Met Leu Pro Ser  Ile Thr Asn 
    2510                 2515                 2520             


Val Ile  Asn Leu Ala Asp Ser  His Asp Arg Ala Ala  Phe Ala Met 
    2525                 2530                 2535             


Val Thr  His Val Lys Gln Glu  Pro Arg Glu Arg Glu  Asn Ser Glu 
    2540                 2545                 2550             


Ser Lys  Glu Glu Asp Val Glu  Ile Asp Ile Glu Leu  Ala Pro Gly 
    2555                 2560                 2565             


Asp Gln  Thr Ser Thr Pro Lys  Thr Lys Glu Leu Ser  Glu Lys Asp 
    2570                 2575                 2580             


Ile Gly  Asn Gln Leu His Met  Leu Thr Asn Arg His  Asp Lys Phe 
    2585                 2590                 2595             


Leu Asp  Thr Leu Arg Glu Val  Lys Thr Gly Ala Leu  Leu Ser Ala 
    2600                 2605                 2610             


Phe Val  Gln Leu Cys His Ile  Ser Thr Thr Leu Ala  Glu Lys Thr 
    2615                 2620                 2625             


Trp Val  Gln Leu Phe Pro Arg  Leu Trp Lys Ile Leu  Ser Asp Arg 
    2630                 2635                 2640             


Gln Gln  His Ala Leu Ala Gly  Glu Ile Ser Pro Phe  Leu Cys Ser 
    2645                 2650                 2655             


Gly Ser  His Gln Val Gln Arg  Asp Cys Gln Pro Ser  Ala Leu Asn 
    2660                 2665                 2670             


Cys Phe  Val Glu Ala Met Ser  Gln Cys Val Pro Pro  Ile Pro Ile 
    2675                 2680                 2685             


Arg Pro  Cys Val Leu Lys Tyr  Leu Gly Lys Thr His  Asn Leu Trp 
    2690                 2695                 2700             


Phe Arg  Ser Thr Leu Met Leu  Glu His Gln Ala Phe  Glu Lys Gly 
    2705                 2710                 2715             


Leu Ser  Leu Gln Ile Lys Pro  Lys Gln Thr Thr Glu  Phe Tyr Glu 
    2720                 2725                 2730             


Gln Glu  Ser Ile Thr Pro Pro  Gln Gln Glu Ile Leu  Asp Ser Leu 
    2735                 2740                 2745             


Ala Glu  Leu Tyr Ser Leu Leu  Gln Glu Glu Asp Met  Trp Ala Gly 
    2750                 2755                 2760             


Leu Trp  Gln Lys Arg Cys Lys  Tyr Ser Glu Thr Ala  Thr Ala Ile 
    2765                 2770                 2775             


Ala Tyr  Glu Gln His Gly Phe  Phe Glu Gln Ala Gln  Glu Ser Tyr 
    2780                 2785                 2790             


Glu Lys  Ala Met Asp Lys Ala  Lys Lys Glu His Glu  Arg Ser Asn 
    2795                 2800                 2805             


Ala Ser  Pro Ala Ile Phe Pro  Glu Tyr Gln Leu Trp  Glu Asp His 
    2810                 2815                 2820             


Trp Ile  Arg Cys Ser Lys Glu  Leu Asn Gln Trp Glu  Ala Leu Thr 
    2825                 2830                 2835             


Glu Tyr  Gly Gln Ser Lys Gly  His Ile Asn Pro Tyr  Leu Val Leu 
    2840                 2845                 2850             


Glu Cys  Ala Trp Arg Val Ser  Asn Trp Thr Ala Met  Lys Glu Ala 
    2855                 2860                 2865             


Leu Val  Gln Val Glu Val Ser  Cys Pro Lys Glu Met  Ala Trp Lys 
    2870                 2875                 2880             


Val Asn  Met Tyr Arg Gly Tyr  Leu Ala Ile Cys His  Pro Glu Glu 
    2885                 2890                 2895             


Gln Gln  Leu Ser Phe Ile Glu  Arg Leu Val Glu Met  Ala Ser Ser 
    2900                 2905                 2910             


Leu Ala  Ile Arg Glu Trp Arg  Arg Leu Pro His Val  Val Ser His 
    2915                 2920                 2925             


Val His  Thr Pro Leu Leu Gln  Ala Ala Gln Gln Ile  Ile Glu Leu 
    2930                 2935                 2940             


Gln Glu  Ala Ala Gln Ile Asn  Ala Gly Leu Gln Pro  Thr Asn Leu 
    2945                 2950                 2955             


Gly Arg  Asn Asn Ser Leu His  Asp Met Lys Thr Val  Val Lys Thr 
    2960                 2965                 2970             


Trp Arg  Asn Arg Leu Pro Ile  Val Ser Asp Asp Leu  Ser His Trp 
    2975                 2980                 2985             


Ser Ser  Ile Phe Met Trp Arg  Gln His His Tyr Gln  Gly Lys Pro 
    2990                 2995                 3000             


Thr Trp  Ser Gly Met His Ser  Ser Ser Ile Val Thr  Ala Tyr Glu 
    3005                 3010                 3015             


Asn Ser  Ser Gln His Asp Pro  Ser Ser Asn Asn Ala  Met Leu Gly 
    3020                 3025                 3030             


Val His  Ala Ser Ala Ser Ala  Ile Ile Gln Tyr Gly  Lys Ile Ala 
    3035                 3040                 3045             


Arg Lys  Gln Gly Leu Val Asn  Val Ala Leu Asp Ile  Leu Ser Arg 
    3050                 3055                 3060             


Ile His  Thr Ile Pro Thr Val  Pro Ile Val Asp Cys  Phe Gln Lys 
    3065                 3070                 3075             


Ile Arg  Gln Gln Val Lys Cys  Tyr Leu Gln Leu Ala  Gly Val Met 
    3080                 3085                 3090             


Gly Lys  Asn Glu Cys Met Gln  Gly Leu Glu Val Ile  Glu Ser Thr 
    3095                 3100                 3105             


Asn Leu  Lys Tyr Phe Thr Lys  Glu Met Thr Ala Glu  Phe Tyr Ala 
    3110                 3115                 3120             


Leu Lys  Gly Met Phe Leu Ala  Gln Ile Asn Lys Ser  Glu Glu Ala 
    3125                 3130                 3135             


Asn Lys  Ala Phe Ser Ala Ala  Val Gln Met His Asp  Val Leu Val 
    3140                 3145                 3150             


Lys Ala  Trp Ala Met Trp Gly  Asp Tyr Leu Glu Asn  Ile Phe Val 
    3155                 3160                 3165             


Lys Glu  Arg Gln Leu His Leu  Gly Val Ser Ala Ile  Thr Cys Tyr 
    3170                 3175                 3180             


Leu His  Ala Cys Arg His Gln  Asn Glu Ser Lys Ser  Arg Lys Tyr 
    3185                 3190                 3195             


Leu Ala  Lys Val Leu Trp Leu  Leu Ser Phe Asp Asp  Asp Lys Asn 
    3200                 3205                 3210             


Thr Leu  Ala Asp Ala Val Asp  Lys Tyr Cys Ile Gly  Val Pro Pro 
    3215                 3220                 3225             


Ile Gln  Trp Leu Ala Trp Ile  Pro Gln Leu Leu Thr  Cys Leu Val 
    3230                 3235                 3240             


Gly Ser  Glu Gly Lys Leu Leu  Leu Asn Leu Ile Ser  Gln Val Gly 
    3245                 3250                 3255             


Arg Val  Tyr Pro Gln Ala Val  Tyr Phe Pro Ile Arg  Thr Leu Tyr 
    3260                 3265                 3270             


Leu Thr  Leu Lys Ile Glu Gln  Arg Glu Arg Tyr Lys  Ser Asp Pro 
    3275                 3280                 3285             


Gly Pro  Ile Arg Ala Thr Ala  Pro Met Trp Arg Cys  Ser Arg Ile 
    3290                 3295                 3300             


Met His  Met Gln Arg Glu Leu  His Pro Thr Leu Leu  Ser Ser Leu 
    3305                 3310                 3315             


Glu Gly  Ile Val Asp Gln Met  Val Trp Phe Arg Glu  Asn Trp His 
    3320                 3325                 3330             


Glu Glu  Val Leu Arg Gln Leu  Gln Gln Gly Leu Ala  Lys Cys Tyr 
    3335                 3340                 3345             


Ser Val  Ala Phe Glu Lys Ser  Gly Ala Val Ser Asp  Ala Lys Ile 
    3350                 3355                 3360             


Thr Pro  His Thr Leu Asn Phe  Val Lys Lys Leu Val  Ser Thr Phe 
    3365                 3370                 3375             


Gly Val  Gly Leu Glu Asn Val  Ser Asn Val Ser Thr  Met Phe Ser 
    3380                 3385                 3390             


Ser Ala  Ala Ser Glu Ser Leu  Ala Arg Arg Ala Gln  Ala Thr Ala 
    3395                 3400                 3405             


Gln Asp  Pro Val Phe Gln Lys  Leu Lys Gly Gln Phe  Thr Thr Asp 
    3410                 3415                 3420             


Phe Asp  Phe Ser Val Pro Gly  Ser Met Lys Leu His  Asn Leu Ile 
    3425                 3430                 3435             


Ser Lys  Leu Lys Lys Trp Ile  Lys Ile Leu Glu Ala  Lys Thr Lys 
    3440                 3445                 3450             


Gln Leu  Pro Lys Phe Phe Leu  Ile Glu Glu Lys Cys  Arg Phe Leu 
    3455                 3460                 3465             


Ser Asn  Phe Ser Ala Gln Thr  Ala Glu Val Glu Ile  Pro Gly Glu 
    3470                 3475                 3480             


Phe Leu  Met Pro Lys Pro Thr  His Tyr Tyr Ile Lys  Ile Ala Arg 
    3485                 3490                 3495             


Phe Met  Pro Arg Val Glu Ile  Val Gln Lys His Asn  Thr Ala Ala 
    3500                 3505                 3510             


Arg Arg  Leu Tyr Ile Arg Gly  His Asn Gly Lys Ile  Tyr Pro Tyr 
    3515                 3520                 3525             


Leu Val  Met Asn Asp Ala Cys  Leu Thr Glu Ser Arg  Arg Glu Glu 
    3530                 3535                 3540             


Arg Val  Leu Gln Leu Leu Arg  Leu Leu Asn Pro Cys  Leu Glu Lys 
    3545                 3550                 3555             


Arg Lys  Glu Thr Thr Lys Arg  His Leu Phe Phe Thr  Val Pro Arg 
    3560                 3565                 3570             


Val Val  Ala Val Ser Pro Gln  Met Arg Leu Val Glu  Asp Asn Pro 
    3575                 3580                 3585             


Ser Ser  Leu Ser Leu Val Glu  Ile Tyr Lys Gln Arg  Cys Ala Lys 
    3590                 3595                 3600             


Lys Gly  Ile Glu His Asp Asn  Pro Ile Ser Arg Tyr  Tyr Asp Arg 
    3605                 3610                 3615             


Leu Ala  Thr Val Gln Ala Arg  Gly Thr Gln Ala Ser  His Gln Val 
    3620                 3625                 3630             


Leu Arg  Asp Ile Leu Lys Glu  Val Gln Ser Asn Met  Val Pro Arg 
    3635                 3640                 3645             


Ser Met  Leu Lys Glu Trp Ala  Leu His Thr Phe Pro  Asn Ala Thr 
    3650                 3655                 3660             


Asp Tyr  Trp Thr Phe Arg Lys  Met Phe Thr Ile Gln  Leu Ala Leu 
    3665                 3670                 3675             


Ile Gly  Phe Ala Glu Phe Val  Leu His Leu Asn Arg  Leu Asn Pro 
    3680                 3685                 3690             


Glu Met  Leu Gln Ile Ala Gln  Asp Thr Gly Lys Leu  Asn Val Ala 
    3695                 3700                 3705             


Tyr Phe  Arg Phe Asp Ile Asn  Asp Ala Thr Gly Asp  Leu Asp Ala 
    3710                 3715                 3720             


Asn Arg  Pro Val Pro Phe Arg  Leu Thr Pro Asn Ile  Ser Glu Phe 
    3725                 3730                 3735             


Leu Thr  Thr Ile Gly Val Ser  Gly Pro Leu Thr Ala  Ser Met Ile 
    3740                 3745                 3750             


Ala Val  Ala Arg Cys Phe Ala  Gln Pro Asn Phe Lys  Val Asp Gly 
    3755                 3760                 3765             


Ile Leu  Lys Thr Val Leu Arg  Asp Glu Ile Ile Ala  Trp His Lys 
    3770                 3775                 3780             


Lys Thr  Gln Glu Asp Thr Ser  Ser Pro Leu Ser Ala  Ala Gly Gln 
    3785                 3790                 3795             


Pro Glu  Asn Met Asp Ser Gln  Gln Leu Val Ser Leu  Val Gln Lys 
    3800                 3805                 3810             


Ala Val  Thr Ala Ile Met Thr  Arg Leu His Asn Leu  Ala Gln Phe 
    3815                 3820                 3825             


Glu Gly  Gly Glu Ser Lys Val  Asn Thr Leu Val Ala  Ala Ala Asn 
    3830                 3835                 3840             


Ser Leu  Asp Asn Leu Cys Arg  Met Asp Pro Ala Trp  His Pro Trp 
    3845                 3850                 3855             


Leu 
    


<210>  420
<211>  3830
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr 
1               5                   10                  15      


Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn 
            20                  25                  30          


Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn 
        35                  40                  45              


Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His 
    50                  55                  60                  


Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe 
65                  70                  75                  80  


Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile 
                85                  90                  95      


Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn 
            100                 105                 110         


Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn 
        115                 120                 125             


Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg 
    130                 135                 140                 


Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln 
145                 150                 155                 160 


Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro 
                165                 170                 175     


Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met 
            180                 185                 190         


Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu 
        195                 200                 205             


Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val 
    210                 215                 220                 


Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys 
225                 230                 235                 240 


Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn 
                245                 250                 255     


Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr 
            260                 265                 270         


Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu 
        275                 280                 285             


Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys 
    290                 295                 300                 


Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys 
305                 310                 315                 320 


Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys 
                325                 330                 335     


His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp 
            340                 345                 350         


Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg 
        355                 360                 365             


Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His 
    370                 375                 380                 


His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln 
385                 390                 395                 400 


Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln 
                405                 410                 415     


Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser 
            420                 425                 430         


Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met 
        435                 440                 445             


Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu 
    450                 455                 460                 


Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val 
465                 470                 475                 480 


Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro 
                485                 490                 495     


Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu 
        515                 520                 525             


Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr 
    530                 535                 540                 


Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile 
545                 550                 555                 560 


Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile 
                565                 570                 575     


Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu 
            580                 585                 590         


Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala 
        595                 600                 605             


Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg 
    610                 615                 620                 


Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr 
625                 630                 635                 640 


Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro 
                645                 650                 655     


Tyr Met Val Glu Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala 
            660                 665                 670         


Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile 
        675                 680                 685             


Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val 
    690                 695                 700                 


Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser 
705                 710                 715                 720 


Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu 
                725                 730                 735     


His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu 
            740                 745                 750         


Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly 
        755                 760                 765             


Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro 
    770                 775                 780                 


Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln 
785                 790                 795                 800 


His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg 
                805                 810                 815     


Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val 
            820                 825                 830         


Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr 
        835                 840                 845             


Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His 
    850                 855                 860                 


Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu 
865                 870                 875                 880 


Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly 
                885                 890                 895     


Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu 
            900                 905                 910         


His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe 
        915                 920                 925             


Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu 
    930                 935                 940                 


Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg 
945                 950                 955                 960 


Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser 
                965                 970                 975     


Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn 
            980                 985                 990         


Phe Thr Glu Lys Thr Ile Pro Asn  Val Ile Ile Ser His  Arg Tyr Lys 
        995                 1000                 1005             


Ala Gln  Asp Thr Pro Ala Arg  Lys Thr Phe Glu Gln  Ala Leu Thr 
    1010                 1015                 1020             


Gly Ala  Phe Met Ser Ala Val  Ile Lys Asp Leu Arg  Pro Ser Ala 
    1025                 1030                 1035             


Leu Pro  Phe Val Ala Ser Leu  Ile Arg His Tyr Thr  Met Val Ala 
    1040                 1045                 1050             


Val Ala  Gln Gln Cys Gly Pro  Phe Leu Leu Pro Cys  Tyr Gln Val 
    1055                 1060                 1065             


Gly Ser  Gln Pro Ser Thr Ala  Met Phe His Ser Glu  Glu Asn Gly 
    1070                 1075                 1080             


Ser Lys  Gly Met Asp Pro Leu  Val Leu Ile Asp Ala  Ile Ala Ile 
    1085                 1090                 1095             


Cys Met  Ala Tyr Glu Glu Lys  Glu Leu Cys Lys Ile  Gly Glu Val 
    1100                 1105                 1110             


Ala Leu  Ala Val Ile Phe Asp  Val Ala Ser Ile Ile  Leu Gly Ser 
    1115                 1120                 1125             


Lys Glu  Arg Ala Cys Gln Leu  Pro Leu Phe Ser Tyr  Ile Val Glu 
    1130                 1135                 1140             


Arg Leu  Cys Ala Cys Cys Tyr  Glu Gln Ala Trp Tyr  Ala Lys Leu 
    1145                 1150                 1155             


Gly Gly  Val Val Ser Ile Lys  Phe Leu Met Glu Arg  Leu Pro Leu 
    1160                 1165                 1170             


Thr Trp  Val Leu Gln Asn Gln  Gln Thr Phe Leu Lys  Ala Leu Leu 
    1175                 1180                 1185             


Phe Val  Met Met Asp Leu Thr  Gly Glu Val Ser Asn  Gly Ala Val 
    1190                 1195                 1200             


Ala Met  Ala Lys Thr Thr Leu  Glu Gln Leu Leu Met  Arg Cys Ala 
    1205                 1210                 1215             


Thr Pro  Leu Lys Asp Glu Glu  Arg Ala Glu Glu Ile  Val Ala Ala 
    1220                 1225                 1230             


Gln Glu  Lys Ser Phe His His  Val Thr His Asp Leu  Val Arg Glu 
    1235                 1240                 1245             


Val Thr  Ser Pro Asn Ser Thr  Val Arg Lys Gln Ala  Met His Ser 
    1250                 1255                 1260             


Leu Gln  Val Leu Ala Gln Val  Thr Gly Lys Ser Val  Thr Val Ile 
    1265                 1270                 1275             


Met Glu  Pro His Lys Glu Val  Leu Gln Asp Met Val  Pro Pro Lys 
    1280                 1285                 1290             


Lys His  Leu Leu Arg His Gln  Pro Ala Asn Ala Gln  Ile Gly Leu 
    1295                 1300                 1305             


Met Glu  Gly Asn Thr Phe Cys  Thr Thr Leu Gln Pro  Arg Leu Phe 
    1310                 1315                 1320             


Thr Met  Asp Leu Asn Val Val  Glu His Lys Val Phe  Tyr Thr Glu 
    1325                 1330                 1335             


Leu Leu  Asn Leu Cys Glu Ala  Glu Asp Ser Ala Leu  Thr Lys Leu 
    1340                 1345                 1350             


Pro Cys  Tyr Lys Ser Leu Pro  Ser Leu Val Pro Leu  Arg Ile Ala 
    1355                 1360                 1365             


Ala Leu  Asn Ala Leu Ala Ala  Cys Asn Tyr Leu Pro  Gln Ser Arg 
    1370                 1375                 1380             


Glu Lys  Ile Ile Ala Ala Leu  Phe Lys Ala Leu Asn  Ser Thr Asn 
    1385                 1390                 1395             


Ser Glu  Leu Gln Glu Ala Gly  Glu Ala Cys Met Arg  Lys Phe Leu 
    1400                 1405                 1410             


Glu Gly  Ala Thr Ile Glu Val  Asp Gln Ile His Thr  His Met Arg 
    1415                 1420                 1425             


Pro Leu  Leu Met Met Leu Gly  Asp Tyr Arg Ser Leu  Thr Leu Asn 
    1430                 1435                 1440             


Val Val  Asn Arg Leu Thr Ser  Val Thr Arg Leu Phe  Pro Asn Ser 
    1445                 1450                 1455             


Phe Asn  Asp Lys Phe Cys Asp  Gln Met Met Gln His  Leu Arg Lys 
    1460                 1465                 1470             


Trp Met  Glu Val Val Val Ile  Thr His Lys Gly Gly  Gln Arg Ser 
    1475                 1480                 1485             


Asp Gly  Asn Glu Met Lys Ile  Cys Ser Ala Ile Ile  Asn Leu Phe 
    1490                 1495                 1500             


His Leu  Ile Pro Ala Ala Pro  Gln Thr Leu Val Lys  Pro Leu Leu 
    1505                 1510                 1515             


Glu Val  Val Met Lys Thr Glu  Arg Ala Met Leu Ile  Glu Ala Gly 
    1520                 1525                 1530             


Ser Pro  Phe Arg Glu Pro Leu  Ile Lys Phe Leu Thr  Arg His Pro 
    1535                 1540                 1545             


Ser Gln  Thr Val Glu Leu Phe  Met Met Glu Ala Thr  Leu Asn Asp 
    1550                 1555                 1560             


Pro Gln  Trp Ser Arg Met Phe  Met Ser Phe Leu Lys  His Lys Asp 
    1565                 1570                 1575             


Ala Arg  Pro Leu Arg Asp Val  Leu Ala Ala Asn Pro  Asn Arg Phe 
    1580                 1585                 1590             


Ile Thr  Leu Leu Leu Pro Gly  Gly Ala Gln Thr Ala  Val Arg Pro 
    1595                 1600                 1605             


Gly Ser  Pro Ser Thr Ser Thr  Met Arg Leu Asp Leu  Gln Phe Gln 
    1610                 1615                 1620             


Ala Ile  Lys Ile Ile Ser Ile  Ile Val Lys Asn Asp  Asp Ser Trp 
    1625                 1630                 1635             


Leu Ala  Ser Gln His Ser Leu  Val Ser Gln Leu Arg  Arg Val Trp 
    1640                 1645                 1650             


Val Ser  Glu Asn Phe Gln Glu  Arg His Arg Lys Glu  Asn Met Ala 
    1655                 1660                 1665             


Ala Thr  Asn Trp Lys Glu Pro  Lys Leu Leu Ala Tyr  Cys Leu Leu 
    1670                 1675                 1680             


Asn Tyr  Cys Lys Arg Asn Tyr  Gly Asp Ile Glu Leu  Leu Phe Gln 
    1685                 1690                 1695             


Leu Leu  Arg Ala Phe Thr Gly  Arg Phe Leu Cys Asn  Met Thr Phe 
    1700                 1705                 1710             


Leu Lys  Glu Tyr Met Glu Glu  Glu Ile Pro Lys Asn  Tyr Ser Ile 
    1715                 1720                 1725             


Ala Gln  Lys Arg Ala Leu Phe  Phe Arg Phe Val Asp  Phe Asn Asp 
    1730                 1735                 1740             


Pro Asn  Phe Gly Asp Glu Leu  Lys Ala Lys Val Leu  Gln His Ile 
    1745                 1750                 1755             


Leu Asn  Pro Ala Phe Leu Tyr  Ser Phe Glu Lys Gly  Glu Gly Glu 
    1760                 1765                 1770             


Gln Leu  Leu Gly Pro Pro Asn  Pro Glu Gly Asp Asn  Pro Glu Ser 
    1775                 1780                 1785             


Ile Thr  Ser Val Phe Ile Thr  Lys Val Leu Asp Pro  Glu Lys Gln 
    1790                 1795                 1800             


Ala Asp  Met Leu Asp Ser Leu  Arg Ile Tyr Leu Leu  Gln Tyr Ala 
    1805                 1810                 1815             


Thr Leu  Leu Val Glu His Ala  Pro His His Ile His  Asp Asn Asn 
    1820                 1825                 1830             


Lys Asn  Arg Asn Ser Lys Leu  Arg Arg Leu Met Thr  Phe Ala Trp 
    1835                 1840                 1845             


Pro Cys  Leu Leu Ser Lys Ala  Cys Val Asp Pro Ala  Cys Lys Tyr 
    1850                 1855                 1860             


Ser Gly  His Leu Leu Leu Ala  His Ile Ile Ala Lys  Phe Ala Ile 
    1865                 1870                 1875             


His Lys  Lys Ile Val Leu Gln  Val Phe His Ser Leu  Leu Lys Ala 
    1880                 1885                 1890             


His Ala  Met Glu Ala Arg Ala  Ile Val Arg Gln Ala  Met Ala Ile 
    1895                 1900                 1905             


Leu Thr  Pro Ala Val Pro Ala  Arg Met Glu Asp Gly  His Gln Met 
    1910                 1915                 1920             


Leu Thr  His Trp Thr Arg Lys  Ile Ile Val Glu Glu  Gly His Thr 
    1925                 1930                 1935             


Val Pro  Gln Leu Val His Ile  Leu His Leu Ile Val  Gln His Phe 
    1940                 1945                 1950             


Lys Val  Tyr Tyr Pro Val Arg  His His Leu Val Gln  His Met Val 
    1955                 1960                 1965             


Ser Ala  Met Gln Arg Leu Gly  Phe Thr Pro Ser Val  Thr Ile Glu 
    1970                 1975                 1980             


Gln Arg  Arg Leu Ala Val Asp  Leu Ser Glu Val Val  Ile Lys Trp 
    1985                 1990                 1995             


Glu Leu  Gln Arg Ile Lys Asp  Gln Gln Pro Asp Ser  Asp Met Asp 
    2000                 2005                 2010             


Pro Asn  Ser Ser Gly Glu Gly  Val Asn Ser Val Ser  Ser Ser Ile 
    2015                 2020                 2025             


Lys Arg  Gly Leu Ser Val Asp  Ser Ala Gln Glu Val  Lys Arg Phe 
    2030                 2035                 2040             


Arg Thr  Ala Thr Gly Ala Ile  Ser Ala Val Phe Gly  Arg Ser Gln 
    2045                 2050                 2055             


Ser Leu  Pro Gly Ala Asp Ser  Leu Leu Ala Lys Pro  Ile Asp Lys 
    2060                 2065                 2070             


Gln His  Thr Asp Thr Val Val  Asn Phe Leu Ile Arg  Val Ala Cys 
    2075                 2080                 2085             


Gln Val  Asn Asp Asn Thr Asn  Thr Ala Gly Ser Pro  Gly Glu Val 
    2090                 2095                 2100             


Leu Ser  Arg Arg Cys Val Asn  Leu Leu Lys Thr Ala  Leu Arg Pro 
    2105                 2110                 2115             


Asp Met  Trp Pro Lys Ser Glu  Leu Lys Leu Gln Trp  Phe Asp Lys 
    2120                 2125                 2130             


Leu Leu  Met Thr Val Glu Gln  Pro Asn Gln Val Asn  Tyr Gly Asn 
    2135                 2140                 2145             


Ile Cys  Thr Gly Leu Glu Val  Leu Ser Phe Leu Leu  Thr Val Leu 
    2150                 2155                 2160             


Gln Ser  Pro Ala Ile Leu Ser  Ser Phe Lys Pro Leu  Gln Arg Gly 
    2165                 2170                 2175             


Ile Ala  Ala Cys Met Thr Cys  Gly Asn Thr Lys Val  Leu Arg Ala 
    2180                 2185                 2190             


Val His  Ser Leu Leu Ser Arg  Leu Met Ser Ile Phe  Pro Thr Glu 
    2195                 2200                 2205             


Pro Ser  Thr Ser Ser Val Ala  Ser Lys Tyr Glu Glu  Leu Glu Cys 
    2210                 2215                 2220             


Leu Tyr  Ala Ala Val Gly Lys  Val Ile Tyr Glu Gly  Leu Thr Asn 
    2225                 2230                 2235             


Tyr Glu  Lys Ala Thr Asn Ala  Asn Pro Ser Gln Leu  Phe Gly Thr 
    2240                 2245                 2250             


Leu Met  Ile Leu Lys Ser Ala  Cys Ser Asn Asn Pro  Ser Tyr Ile 
    2255                 2260                 2265             


Asp Arg  Leu Ile Ser Val Phe  Met Arg Ser Leu Gln  Lys Met Val 
    2270                 2275                 2280             


Arg Glu  His Leu Asn Pro Gln  Ala Ala Ser Gly Ser  Thr Glu Ala 
    2285                 2290                 2295             


Thr Ser  Gly Thr Ser Glu Leu  Val Met Leu Ser Leu  Glu Leu Val 
    2300                 2305                 2310             


Lys Thr  Arg Leu Ala Val Met  Ser Met Glu Met Arg  Lys Asn Phe 
    2315                 2320                 2325             


Ile Gln  Ala Ile Leu Thr Ser  Leu Ile Glu Lys Ser  Pro Asp Ala 
    2330                 2335                 2340             


Lys Ile  Leu Arg Ala Val Val  Lys Ile Val Glu Glu  Trp Val Lys 
    2345                 2350                 2355             


Asn Asn  Ser Pro Met Ala Ala  Asn Gln Thr Pro Thr  Leu Arg Glu 
    2360                 2365                 2370             


Lys Ser  Ile Leu Leu Val Lys  Met Met Thr Tyr Ile  Glu Lys Arg 
    2375                 2380                 2385             


Phe Pro  Glu Asp Leu Glu Leu  Asn Ala Gln Phe Leu  Asp Leu Val 
    2390                 2395                 2400             


Asn Tyr  Val Tyr Arg Asp Glu  Thr Leu Ser Gly Ser  Glu Leu Thr 
    2405                 2410                 2415             


Ala Lys  Leu Glu Pro Ala Phe  Leu Ser Gly Leu Arg  Cys Ala Gln 
    2420                 2425                 2430             


Pro Leu  Ile Arg Ala Lys Phe  Phe Glu Val Phe Asp  Asn Ser Met 
    2435                 2440                 2445             


Lys Arg  Arg Val Tyr Glu Arg  Leu Leu Tyr Val Thr  Cys Ser Gln 
    2450                 2455                 2460             


Asn Trp  Glu Ala Met Gly Asn  His Phe Trp Ile Lys  Gln Cys Ile 
    2465                 2470                 2475             


Glu Leu  Leu Leu Ala Val Cys  Glu Lys Ser Thr Pro  Ile Gly Thr 
    2480                 2485                 2490             


Ser Cys  Gln Gly Ala Met Leu  Pro Ser Ile Thr Asn  Val Ile Asn 
    2495                 2500                 2505             


Leu Ala  Asp Ser His Asp Arg  Ala Ala Phe Ala Met  Val Thr His 
    2510                 2515                 2520             


Val Lys  Gln Glu Pro Arg Glu  Arg Glu Asn Ser Glu  Ser Lys Glu 
    2525                 2530                 2535             


Glu Asp  Val Glu Ile Asp Ile  Glu Leu Ala Pro Gly  Asp Gln Thr 
    2540                 2545                 2550             


Ser Thr  Pro Lys Thr Lys Glu  Leu Ser Glu Lys Asp  Ile Gly Asn 
    2555                 2560                 2565             


Gln Leu  His Met Leu Thr Asn  Arg His Asp Lys Phe  Leu Asp Thr 
    2570                 2575                 2580             


Leu Arg  Glu Val Lys Thr Gly  Ala Leu Leu Ser Ala  Phe Val Gln 
    2585                 2590                 2595             


Leu Cys  His Ile Ser Thr Thr  Leu Ala Glu Lys Thr  Trp Val Gln 
    2600                 2605                 2610             


Leu Phe  Pro Arg Leu Trp Lys  Ile Leu Ser Asp Arg  Gln Gln His 
    2615                 2620                 2625             


Ala Leu  Ala Gly Glu Ile Ser  Pro Phe Leu Cys Ser  Gly Ser His 
    2630                 2635                 2640             


Gln Val  Gln Arg Asp Cys Gln  Pro Ser Ala Leu Asn  Cys Phe Val 
    2645                 2650                 2655             


Glu Ala  Met Ser Gln Cys Val  Pro Pro Ile Pro Ile  Arg Pro Cys 
    2660                 2665                 2670             


Val Leu  Lys Tyr Leu Gly Lys  Thr His Asn Leu Trp  Phe Arg Ser 
    2675                 2680                 2685             


Thr Leu  Met Leu Glu His Gln  Ala Phe Glu Lys Gly  Leu Ser Leu 
    2690                 2695                 2700             


Gln Ile  Lys Pro Lys Gln Thr  Thr Glu Phe Tyr Glu  Gln Glu Ser 
    2705                 2710                 2715             


Ile Thr  Pro Pro Gln Gln Glu  Ile Leu Asp Ser Leu  Ala Glu Leu 
    2720                 2725                 2730             


Tyr Ser  Leu Leu Gln Glu Glu  Asp Met Trp Ala Gly  Leu Trp Gln 
    2735                 2740                 2745             


Lys Arg  Cys Lys Tyr Ser Glu  Thr Ala Thr Ala Ile  Ala Tyr Glu 
    2750                 2755                 2760             


Gln His  Gly Phe Phe Glu Gln  Ala Gln Glu Ser Tyr  Glu Lys Ala 
    2765                 2770                 2775             


Met Asp  Lys Ala Lys Lys Glu  His Glu Arg Ser Asn  Ala Ser Pro 
    2780                 2785                 2790             


Ala Ile  Phe Pro Glu Tyr Gln  Leu Trp Glu Asp His  Trp Ile Arg 
    2795                 2800                 2805             


Cys Ser  Lys Glu Leu Asn Gln  Trp Glu Ala Leu Thr  Glu Tyr Gly 
    2810                 2815                 2820             


Gln Ser  Lys Gly His Ile Asn  Pro Tyr Leu Val Leu  Glu Cys Ala 
    2825                 2830                 2835             


Trp Arg  Val Ser Asn Trp Thr  Ala Met Lys Glu Ala  Leu Val Gln 
    2840                 2845                 2850             


Val Glu  Val Ser Cys Pro Lys  Glu Met Ala Trp Lys  Val Asn Met 
    2855                 2860                 2865             


Tyr Arg  Gly Tyr Leu Ala Ile  Cys His Pro Glu Glu  Gln Gln Leu 
    2870                 2875                 2880             


Ser Phe  Ile Glu Arg Leu Val  Glu Met Ala Ser Ser  Leu Ala Ile 
    2885                 2890                 2895             


Arg Glu  Trp Arg Arg Leu Pro  His Val Val Ser His  Val His Thr 
    2900                 2905                 2910             


Pro Leu  Leu Gln Ala Ala Gln  Gln Ile Ile Glu Leu  Gln Glu Ala 
    2915                 2920                 2925             


Ala Gln  Ile Asn Ala Gly Leu  Gln Pro Thr Asn Leu  Gly Arg Asn 
    2930                 2935                 2940             


Asn Ser  Leu His Asp Met Lys  Thr Val Val Lys Thr  Trp Arg Asn 
    2945                 2950                 2955             


Arg Leu  Pro Ile Val Ser Asp  Asp Leu Ser His Trp  Ser Ser Ile 
    2960                 2965                 2970             


Phe Met  Trp Arg Gln His His  Tyr Gln Ala Ile Val  Thr Ala Tyr 
    2975                 2980                 2985             


Glu Asn  Ser Ser Gln His Asp  Pro Ser Ser Asn Asn  Ala Met Leu 
    2990                 2995                 3000             


Gly Val  His Ala Ser Ala Ser  Ala Ile Ile Gln Tyr  Gly Lys Ile 
    3005                 3010                 3015             


Ala Arg  Lys Gln Gly Leu Val  Asn Val Ala Leu Asp  Ile Leu Ser 
    3020                 3025                 3030             


Arg Ile  His Thr Ile Pro Thr  Val Pro Ile Val Asp  Cys Phe Gln 
    3035                 3040                 3045             


Lys Ile  Arg Gln Gln Val Lys  Cys Tyr Leu Gln Leu  Ala Gly Val 
    3050                 3055                 3060             


Met Gly  Lys Asn Glu Cys Met  Gln Gly Leu Glu Val  Ile Glu Ser 
    3065                 3070                 3075             


Thr Asn  Leu Lys Tyr Phe Thr  Lys Glu Met Thr Ala  Glu Phe Tyr 
    3080                 3085                 3090             


Ala Leu  Lys Gly Met Phe Leu  Ala Gln Ile Asn Lys  Ser Glu Glu 
    3095                 3100                 3105             


Ala Asn  Lys Ala Phe Ser Ala  Ala Val Gln Met His  Asp Val Leu 
    3110                 3115                 3120             


Val Lys  Ala Trp Ala Met Trp  Gly Asp Tyr Leu Glu  Asn Ile Phe 
    3125                 3130                 3135             


Val Lys  Glu Arg Gln Leu His  Leu Gly Val Ser Ala  Ile Thr Cys 
    3140                 3145                 3150             


Tyr Leu  His Ala Cys Arg His  Gln Asn Glu Ser Lys  Ser Arg Lys 
    3155                 3160                 3165             


Tyr Leu  Ala Lys Val Leu Trp  Leu Leu Ser Phe Asp  Asp Asp Lys 
    3170                 3175                 3180             


Asn Thr  Leu Ala Asp Ala Val  Asp Lys Tyr Cys Ile  Gly Val Pro 
    3185                 3190                 3195             


Pro Ile  Gln Trp Leu Ala Trp  Ile Pro Gln Leu Leu  Thr Cys Leu 
    3200                 3205                 3210             


Val Gly  Ser Glu Gly Lys Leu  Leu Leu Asn Leu Ile  Ser Gln Val 
    3215                 3220                 3225             


Gly Arg  Val Tyr Pro Gln Ala  Val Tyr Phe Pro Ile  Arg Thr Leu 
    3230                 3235                 3240             


Tyr Leu  Thr Leu Lys Ile Glu  Gln Arg Glu Arg Tyr  Lys Ser Asp 
    3245                 3250                 3255             


Pro Gly  Pro Ile Arg Ala Thr  Ala Pro Met Trp Arg  Cys Ser Arg 
    3260                 3265                 3270             


Ile Met  His Met Gln Arg Glu  Leu His Pro Thr Leu  Leu Ser Ser 
    3275                 3280                 3285             


Leu Glu  Gly Ile Val Asp Gln  Met Val Trp Phe Arg  Glu Asn Trp 
    3290                 3295                 3300             


His Glu  Glu Val Leu Arg Gln  Leu Gln Gln Gly Leu  Ala Lys Cys 
    3305                 3310                 3315             


Tyr Ser  Val Ala Phe Glu Lys  Ser Gly Ala Val Ser  Asp Ala Lys 
    3320                 3325                 3330             


Ile Thr  Pro His Thr Leu Asn  Phe Val Lys Lys Leu  Val Ser Thr 
    3335                 3340                 3345             


Phe Gly  Val Gly Leu Glu Asn  Val Ser Asn Val Ser  Thr Met Phe 
    3350                 3355                 3360             


Ser Ser  Ala Ala Ser Glu Ser  Leu Ala Arg Arg Ala  Gln Ala Thr 
    3365                 3370                 3375             


Ala Gln  Asp Pro Val Phe Gln  Lys Leu Lys Gly Gln  Phe Thr Thr 
    3380                 3385                 3390             


Asp Phe  Asp Phe Ser Val Pro  Gly Ser Met Lys Leu  His Asn Leu 
    3395                 3400                 3405             


Ile Ser  Lys Leu Lys Lys Trp  Ile Lys Ile Leu Glu  Ala Lys Thr 
    3410                 3415                 3420             


Lys Gln  Leu Pro Lys Phe Phe  Leu Ile Glu Glu Lys  Cys Arg Phe 
    3425                 3430                 3435             


Leu Ser  Asn Phe Ser Ala Gln  Thr Ala Glu Val Glu  Ile Pro Gly 
    3440                 3445                 3450             


Glu Phe  Leu Met Pro Lys Pro  Thr His Tyr Tyr Ile  Lys Ile Ala 
    3455                 3460                 3465             


Arg Phe  Met Pro Arg Val Glu  Ile Val Gln Lys His  Asn Thr Ala 
    3470                 3475                 3480             


Ala Arg  Arg Leu Tyr Ile Arg  Gly His Asn Gly Lys  Ile Tyr Pro 
    3485                 3490                 3495             


Tyr Leu  Val Met Asn Asp Ala  Cys Leu Thr Glu Ser  Arg Arg Glu 
    3500                 3505                 3510             


Glu Arg  Val Leu Gln Leu Leu  Arg Leu Leu Asn Pro  Cys Leu Glu 
    3515                 3520                 3525             


Lys Arg  Lys Glu Thr Thr Lys  Arg His Leu Phe Phe  Thr Val Pro 
    3530                 3535                 3540             


Arg Val  Val Ala Val Ser Pro  Gln Met Arg Leu Val  Glu Asp Asn 
    3545                 3550                 3555             


Pro Ser  Ser Leu Ser Leu Val  Glu Ile Tyr Lys Gln  Arg Cys Ala 
    3560                 3565                 3570             


Lys Lys  Gly Ile Glu His Asp  Asn Pro Ile Ser Arg  Tyr Tyr Asp 
    3575                 3580                 3585             


Arg Leu  Ala Thr Val Gln Ala  Arg Gly Thr Gln Ala  Ser His Gln 
    3590                 3595                 3600             


Val Leu  Arg Asp Ile Leu Lys  Glu Val Gln Ser Asn  Met Val Pro 
    3605                 3610                 3615             


Arg Ser  Met Leu Lys Glu Trp  Ala Leu His Thr Phe  Pro Asn Ala 
    3620                 3625                 3630             


Thr Asp  Tyr Trp Thr Phe Arg  Lys Met Phe Thr Ile  Gln Leu Ala 
    3635                 3640                 3645             


Leu Ile  Gly Phe Ala Glu Phe  Val Leu His Leu Asn  Arg Leu Asn 
    3650                 3655                 3660             


Pro Glu  Met Leu Gln Ile Ala  Gln Asp Thr Gly Lys  Leu Asn Val 
    3665                 3670                 3675             


Ala Tyr  Phe Arg Phe Asp Ile  Asn Asp Ala Thr Gly  Asp Leu Asp 
    3680                 3685                 3690             


Ala Asn  Arg Pro Val Pro Phe  Arg Leu Thr Pro Asn  Ile Ser Glu 
    3695                 3700                 3705             


Phe Leu  Thr Thr Ile Gly Val  Ser Gly Pro Leu Thr  Ala Ser Met 
    3710                 3715                 3720             


Ile Ala  Val Ala Arg Cys Phe  Ala Gln Pro Asn Phe  Lys Val Asp 
    3725                 3730                 3735             


Gly Ile  Leu Lys Thr Val Leu  Arg Asp Glu Ile Ile  Ala Trp His 
    3740                 3745                 3750             


Lys Lys  Thr Gln Glu Asp Thr  Ser Ser Pro Leu Ser  Ala Ala Gly 
    3755                 3760                 3765             


Gln Pro  Glu Asn Met Asp Ser  Gln Gln Leu Val Ser  Leu Val Gln 
    3770                 3775                 3780             


Lys Ala  Val Thr Ala Ile Met  Thr Arg Leu His Asn  Leu Ala Gln 
    3785                 3790                 3795             


Phe Glu  Gly Gly Glu Ser Lys  Val Asn Thr Leu Val  Ala Ala Ala 
    3800                 3805                 3810             


Asn Ser  Leu Asp Asn Leu Cys  Arg Met Asp Pro Ala  Trp His Pro 
    3815                 3820                 3825             


Trp Leu  
    3830 


<210>  421
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  422
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  423
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu 
            340                 345                 350         


Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser 
        355                 360                 365             


Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn 
    370                 375                 380                 


Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
385                 390                 395 


<210>  424
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe 
            340                 345                 350         


Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser 
        355                 360                 365             


Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys 
    370                 375                 380                 


Asp Lys Pro Arg Arg 
385                 


<210>  425
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 
        355                 360                 365             


Pro Arg Arg 
    370     


<210>  426
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Met 
        


<210>  427
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Cys Asp Lys Pro Arg Arg 
                325         


<210>  428
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
                325                 330                 335     


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
            340                 345                 350         


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr 
        355                 360                 365             


Arg Lys Asp 
    370     


<210>  429
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Cys Asp Lys Pro Arg Arg 
305                 310                 315         


<210>  430
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210>  431
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His 
                165                 170                 175     


Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr 
            180                 185                 190         


Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys 
        195                 200                 205             


Arg Cys Asp Lys Pro Arg Arg 
    210                 215 


<210>  432
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Pro 
145                 150                 155                 160 


Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro 
                165                 170                 175     


Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala 
            180                 185                 190         


Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg 
        195                 200                 205             


Arg 
    


<210>  433
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210>  434
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Met 
                165                 170                 


<210>  435
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Cys Asp Lys 
    130                 135                 140                 


Pro Arg Arg 
145         


<210>  436
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr Arg Lys Asp 
            180                 185                 190     


<210>  437
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  437

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Cys Asp Lys Pro Arg Arg 
    130                 135         


<210>  438
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Cys Asp Lys Pro Arg Arg 
                165                 170     


<210>  439
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  439

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Cys Asp Lys Pro Arg Arg 
            340                 345                 350     


<210>  440
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
1               5                   10                  15      


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
            20                  25                  30          


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
        35                  40                  45              


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
    50                  55                  60                  


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
65                  70                  75                  80  


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
                85                  90                  95      


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
            100                 105                 110         


Asn Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln 
        115                 120                 125             


Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys 
    130                 135                 140                 


Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys 
145                 150                 155                 160 


Pro Arg Arg 
            


<210>  441
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  441

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg Ser 
            180                 185                 190         


Ala Gly Gln Glu Glu Gly Ala Ser Leu Arg Val Ser Gly Thr Arg Ser 
        195                 200                 205             


Leu Thr Arg Lys Asp 
    210             


<210>  442
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Glu Thr Ala Pro Lys Pro Gly Lys Asp Val Pro Pro Lys Lys Asp 
1               5                   10                  15      


Lys Leu Gln Thr Lys Arg Lys Lys Pro Arg Arg Tyr Trp Glu Glu Glu 
            20                  25                  30          


Thr Val Pro Thr Thr Ala Gly Ala Ser Pro Gly Pro Pro Arg Asn Lys 
        35                  40                  45              


Lys Asn Arg Glu Leu Arg Pro Gln Arg Pro Lys Asn Ala Tyr Ile Leu 
    50                  55                  60                  


Lys Lys Ser Arg Ile Ser Lys Lys Pro Gln Val Pro Lys Lys Pro Arg 
65                  70                  75                  80  


Glu Trp Lys Asn Pro Glu Ser Gln Arg Gly Leu Ser Gly Thr Gln Asp 
                85                  90                  95      


Pro Phe Pro Gly Pro Ala Pro Val Pro Val Glu Val Val Gln Lys Phe 
            100                 105                 110         


Cys Arg Ile Asp Lys Ser Arg Lys Leu Pro His Ser Lys Ala Lys Thr 
        115                 120                 125             


Arg Ser Arg Leu Glu Val Ala Glu Ala Glu Glu Glu Glu Thr Ser Ile 
    130                 135                 140                 


Lys Ala Ala Arg Ser Glu Leu Leu Leu Ala Glu Glu Pro Gly Phe Leu 
145                 150                 155                 160 


Glu Gly Glu Asp Gly Glu Asp Thr Ala Lys Ile Cys Gln Ala Asp Ile 
                165                 170                 175     


Val Glu Ala Val Asp Ile Ala Ser Ala Ala Lys His Phe Asp Leu Asn 
            180                 185                 190         


Leu Arg Gln Phe Gly Pro Tyr Arg Leu Asn Tyr Ser Arg Thr Gly Arg 
        195                 200                 205             


His Leu Ala Phe Gly Gly Arg Arg Gly His Val Ala Ala Leu Asp Trp 
    210                 215                 220                 


Val Thr Lys Lys Leu Met Cys Glu Ile Asn Val Met Glu Ala Val Arg 
225                 230                 235                 240 


Asp Ile Arg Phe Leu His Ser Glu Ala Leu Leu Ala Val Ala Gln Asn 
                245                 250                 255     


Arg Trp Leu His Ile Tyr Asp Asn Gln Gly Ile Glu Leu His Cys Ile 
            260                 265                 270         


Arg Arg Cys Asp Arg Val Thr Arg Leu Glu Phe Leu Pro Phe His Phe 
        275                 280                 285             


Leu Leu Ala Thr Ala Ser Glu Thr Gly Phe Leu Thr Tyr Leu Asp Val 
    290                 295                 300                 


Ser Val Gly Lys Ile Val Ala Ala Leu Asn Ala Arg Ala Gly Arg Leu 
305                 310                 315                 320 


Asp Val Met Ser Gln Asn Pro Tyr Asn Ala Val Ile His Leu Gly His 
                325                 330                 335     


Ser Asn Gly Thr Val Ser Leu Trp Ser Pro Ala Met Lys Glu Pro Leu 
            340                 345                 350         


Ala Lys Ile Leu Cys His Arg Gly Gly Val Arg Ala Val Ala Val Asp 
        355                 360                 365             


Ser Thr Gly Thr Tyr Met Ala Thr Ser Gly Leu Asp His Gln Leu Lys 
    370                 375                 380                 


Ile Phe Asp Leu Arg Gly Thr Tyr Gln Pro Leu Ser Thr Arg Thr Leu 
385                 390                 395                 400 


Pro His Gly Ala Gly His Leu Ala Phe Ser Gln Arg Gly Leu Leu Val 
                405                 410                 415     


Ala Gly Met Gly Asp Val Val Asn Ile Trp Ala Gly Gln Gly Lys Ala 
            420                 425                 430         


Ser Pro Pro Ser Leu Glu Gln Pro Tyr Leu Thr His Arg Leu Ser Gly 
        435                 440                 445             


Pro Val His Gly Leu Gln Phe Cys Pro Phe Glu Asp Val Leu Gly Val 
    450                 455                 460                 


Gly His Thr Gly Gly Ile Thr Ser Met Leu Val Pro Gly Ala Gly Glu 
465                 470                 475                 480 


Pro Asn Phe Asp Gly Leu Glu Ser Asn Pro Tyr Arg Ser Arg Lys Gln 
                485                 490                 495     


Arg Gln Glu Trp Glu Val Lys Ala Leu Leu Glu Lys Val Pro Ala Glu 
            500                 505                 510         


Leu Ile Cys Leu Asp Pro Arg Ala Leu Ala Glu Val Asp Val Ile Ser 
        515                 520                 525             


Leu Glu Gln Gly Lys Lys Glu Gln Ile Glu Arg Leu Gly Tyr Asp Pro 
    530                 535                 540                 


Gln Ala Lys Ala Pro Phe Gln Pro Lys Pro Lys Gln Lys Gly Arg Ser 
545                 550                 555                 560 


Ser Thr Ala Ser Leu Val Lys Arg Lys Arg Lys Val Met Asp Glu Glu 
                565                 570                 575     


His Arg Asp Lys Val Arg Gln Ser Leu Gln Gln Gln His His Lys Glu 
            580                 585                 590         


Ala Lys Ala Lys Pro Thr Gly Ala Arg Pro Ser Ala Leu Asp Arg Phe 
        595                 600                 605             


Val Arg 
    610 


<210>  443
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Glu Thr Ala Pro Lys Pro Gly Lys Asp Val Pro Pro Lys Lys Asp 
1               5                   10                  15      


Lys Leu Gln Thr Lys Arg Lys Lys Pro Arg Glu Trp Lys Asn Pro Glu 
            20                  25                  30          


Ser Gln Arg Gly Leu Ser Gly Thr Gln Asp Pro Phe Pro Gly Pro Ala 
        35                  40                  45              


Pro Val Pro Val Glu Val Val Gln Lys Phe Cys Arg Ile Asp Lys Ser 
    50                  55                  60                  


Arg Lys Leu Pro His Ser Lys Ala Lys Thr Arg Ser Arg Leu Glu Val 
65                  70                  75                  80  


Ala Glu Ala Glu Glu Glu Glu Thr Ser Ile Lys Ala Ala Arg Ser Glu 
                85                  90                  95      


Leu Leu Leu Ala Glu Glu Pro Gly Phe Leu Glu Gly Glu Asp Gly Glu 
            100                 105                 110         


Asp Thr Ala Lys Ile Cys Gln Ala Asp Ile Val Glu Ala Val Asp Ile 
        115                 120                 125             


Ala Ser Ala Ala Lys His Phe Asp Leu Asn Leu Arg Gln Phe Gly Pro 
    130                 135                 140                 


Tyr Arg Leu Asn Tyr Ser Arg Thr Gly Arg His Leu Ala Phe Gly Gly 
145                 150                 155                 160 


Arg Arg Gly His Val Ala Ala Leu Asp Trp Val Thr Lys Lys Leu Met 
                165                 170                 175     


Cys Glu Ile Asn Val Met Glu Ala Val Arg Asp Ile Arg Phe Leu His 
            180                 185                 190         


Ser Glu Ala Leu Leu Ala Val Ala Gln Asn Arg Trp Leu His Ile Tyr 
        195                 200                 205             


Asp Asn Gln Gly Ile Glu Leu His Cys Ile Arg Arg Cys Asp Arg Val 
    210                 215                 220                 


Thr Arg Leu Glu Phe Leu Pro Phe His Phe Leu Leu Ala Thr Ala Ser 
225                 230                 235                 240 


Glu Thr Gly Phe Leu Thr Tyr Leu Asp Val Ser Val Gly Lys Ile Val 
                245                 250                 255     


Ala Ala Leu Asn Ala Arg Ala Gly Arg Leu Asp Val Met Ser Gln Asn 
            260                 265                 270         


Pro Tyr Asn Ala Val Ile His Leu Gly His Ser Asn Gly Thr Val Ser 
        275                 280                 285             


Leu Trp Ser Pro Ala Met Lys Glu Pro Leu Ala Lys Ile Leu Cys His 
    290                 295                 300                 


Arg Gly Gly Val Arg Ala Val Ala Val Asp Ser Thr Gly Thr Tyr Met 
305                 310                 315                 320 


Ala Thr Ser Gly Leu Asp His Gln Leu Lys Ile Phe Asp Leu Arg Gly 
                325                 330                 335     


Thr Tyr Gln Pro Leu Ser Thr Arg Thr Leu Pro His Gly Ala Gly His 
            340                 345                 350         


Leu Ala Phe Ser Gln Arg Gly Leu Leu Val Ala Gly Met Gly Asp Val 
        355                 360                 365             


Val Asn Ile Trp Ala Gly Gln Gly Lys Ala Ser Pro Pro Ser Leu Glu 
    370                 375                 380                 


Gln Pro Tyr Leu Thr His Arg Leu Ser Gly Pro Val His Gly Leu Gln 
385                 390                 395                 400 


Phe Cys Pro Phe Glu Asp Val Leu Gly Val Gly His Thr Gly Gly Ile 
                405                 410                 415     


Thr Ser Met Leu Val Pro Gly Ala Gly Glu Pro Asn Phe Asp Gly Leu 
            420                 425                 430         


Glu Ser Asn Pro Tyr Arg Ser Arg Lys Gln Arg Gln Glu Trp Glu Val 
        435                 440                 445             


Lys Ala Leu Leu Glu Lys Val Pro Ala Glu Leu Ile Cys Leu Asp Pro 
    450                 455                 460                 


Arg Ala Leu Ala Glu Val Asp Val Ile Ser Leu Glu Gln Gly Lys Lys 
465                 470                 475                 480 


Glu Gln Ile Glu Arg Leu Gly Tyr Asp Pro Gln Ala Lys Ala Pro Phe 
                485                 490                 495     


Gln Pro Lys Pro Lys Gln Lys Gly Arg Ser Ser Thr Ala Ser Leu Val 
            500                 505                 510         


Lys Arg Lys Arg Lys Val Met Asp Glu Glu His Arg Asp Lys Val Arg 
        515                 520                 525             


Gln Ser Leu Gln Gln Gln His His Lys Glu Ala Lys Ala Lys Pro Thr 
    530                 535                 540                 


Gly Ala Arg Pro Ser Ala Leu Asp Arg Phe Val Arg 
545                 550                 555     


<210>  444
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Asp Phe Leu Leu Leu Gln Asp Pro Ala Ser Thr Cys Val Pro Glu 
1               5                   10                  15      


Pro Ala Ser Gln His Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln 
            20                  25                  30          


Pro Glu Gln Gln Gly Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu 
        35                  40                  45              


Gly Ala Ala Glu Ala Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ala Ser Gly Ser Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp 
65                  70                  75                  80  


Leu Asn Ala Leu Leu Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly 
                85                  90                  95      


Cys Ala Leu Pro Val Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp 
            100                 105                 110         


Phe Ala Pro Pro Gly Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala 
        115                 120                 125             


Pro Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe 
    130                 135                 140                 


Ile Lys Gln Glu Pro Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln 
145                 150                 155                 160 


Cys Leu Ser Ala Phe Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr 
                165                 170                 175     


Ala Gly Ala Cys Arg Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln 
            180                 185                 190         


Ala Ser Ser Gly Gln Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro 
        195                 200                 205             


Ser Cys Leu Glu Ser Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr 
    210                 215                 220                 


Val Thr Phe Asp Gly Thr Pro Ser Tyr Gly His Thr Pro Ser His His 
225                 230                 235                 240 


Ala Ala Gln Phe Pro Asn His Ser Phe Lys His Glu Asp Pro Met Gly 
                245                 250                 255     


Gln Gln Gly Ser Leu Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val 
            260                 265                 270         


Tyr Gly Cys His Thr Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu 
        275                 280                 285             


Leu Leu Arg Thr Pro Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser 
    290                 295                 300                 


Gln Leu Glu Cys Met Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Lys Gly His Ser Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro Ile 
                325                 330                 335     


Leu Cys Gly Ala Gln Tyr Arg Ile His Thr His Gly Val Phe Arg Gly 
            340                 345                 350         


Ile Gln Asp Val Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val Arg 
        355                 360                 365             


Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr Pro 
    370                 375                 380                 


Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser 
385                 390                 395                 400 


Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp Cys 
                405                 410                 415     


Glu Arg Arg Phe Ser Arg Ser Asp Gln Leu Lys Arg His Gln Arg Arg 
            420                 425                 430         


His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe 
        435                 440                 445             


Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His Thr Gly Glu 
    450                 455                 460                 


Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg 
465                 470                 475                 480 


Ser Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn Met Thr 
                485                 490                 495     


Lys Leu Gln Leu Ala Leu 
            500         


<210>  445
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Asp Phe Leu Leu Leu Gln Asp Pro Ala Ser Thr Cys Val Pro Glu 
1               5                   10                  15      


Pro Ala Ser Gln His Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln 
            20                  25                  30          


Pro Glu Gln Gln Gly Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu 
        35                  40                  45              


Gly Ala Ala Glu Ala Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ala Ser Gly Ser Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp 
65                  70                  75                  80  


Leu Asn Ala Leu Leu Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly 
                85                  90                  95      


Cys Ala Leu Pro Val Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp 
            100                 105                 110         


Phe Ala Pro Pro Gly Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala 
        115                 120                 125             


Pro Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe 
    130                 135                 140                 


Ile Lys Gln Glu Pro Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln 
145                 150                 155                 160 


Cys Leu Ser Ala Phe Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr 
                165                 170                 175     


Ala Gly Ala Cys Arg Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln 
            180                 185                 190         


Ala Ser Ser Gly Gln Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro 
        195                 200                 205             


Ser Cys Leu Glu Ser Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr 
    210                 215                 220                 


Val Thr Phe Asp Gly Thr Pro Ser Tyr Gly His Thr Pro Ser His His 
225                 230                 235                 240 


Ala Ala Gln Phe Pro Asn His Ser Phe Lys His Glu Asp Pro Met Gly 
                245                 250                 255     


Gln Gln Gly Ser Leu Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val 
            260                 265                 270         


Tyr Gly Cys His Thr Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu 
        275                 280                 285             


Leu Leu Arg Thr Pro Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser 
    290                 295                 300                 


Gln Leu Glu Cys Met Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Lys Gly Val Ala Ala Gly Ser Ser Ser Ser Val Lys Trp Thr Glu Gly 
                325                 330                 335     


Gln Ser Asn His Ser Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro 
            340                 345                 350         


Ile Leu Cys Gly Ala Gln Tyr Arg Ile His Thr His Gly Val Phe Arg 
        355                 360                 365             


Gly Ile Gln Asp Val Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val 
    370                 375                 380                 


Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr 
385                 390                 395                 400 


Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met His 
                405                 410                 415     


Ser Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp 
            420                 425                 430         


Cys Glu Arg Arg Phe Ser Arg Ser Asp Gln Leu Lys Arg His Gln Arg 
        435                 440                 445             


Arg His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His Thr Gly 
465                 470                 475                 480 


Glu Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala 
                485                 490                 495     


Arg Ser Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn Met 
            500                 505                 510         


Thr Lys Leu Gln Leu Ala Leu 
        515                 


<210>  446
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Asp Phe Leu Leu Leu Gln Asp Pro Ala Ser Thr Cys Val Pro Glu 
1               5                   10                  15      


Pro Ala Ser Gln His Thr Leu Arg Ser Gly Pro Gly Cys Leu Gln Gln 
            20                  25                  30          


Pro Glu Gln Gln Gly Val Arg Asp Pro Gly Gly Ile Trp Ala Lys Leu 
        35                  40                  45              


Gly Ala Ala Glu Ala Ser Ala Glu Arg Leu Gln Gly Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ala Ser Gly Ser Glu Pro Gln Gln Met Gly Ser Asp Val Arg Asp 
65                  70                  75                  80  


Leu Asn Ala Leu Leu Pro Ala Val Pro Ser Leu Gly Gly Gly Gly Gly 
                85                  90                  95      


Cys Ala Leu Pro Val Ser Gly Ala Ala Gln Trp Ala Pro Val Leu Asp 
            100                 105                 110         


Phe Ala Pro Pro Gly Ala Ser Ala Tyr Gly Ser Leu Gly Gly Pro Ala 
        115                 120                 125             


Pro Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro His Ser Phe 
    130                 135                 140                 


Ile Lys Gln Glu Pro Ser Trp Gly Gly Ala Glu Pro His Glu Glu Gln 
145                 150                 155                 160 


Cys Leu Ser Ala Phe Thr Val His Phe Ser Gly Gln Phe Thr Gly Thr 
                165                 170                 175     


Ala Gly Ala Cys Arg Tyr Gly Pro Phe Gly Pro Pro Pro Pro Ser Gln 
            180                 185                 190         


Ala Ser Ser Gly Gln Ala Arg Met Phe Pro Asn Ala Pro Tyr Leu Pro 
        195                 200                 205             


Ser Cys Leu Glu Ser Gln Pro Ala Ile Arg Asn Gln Gly Tyr Ser Thr 
    210                 215                 220                 


Val Thr Phe Asp Gly Thr Pro Ser Tyr Gly His Thr Pro Ser His His 
225                 230                 235                 240 


Ala Ala Gln Phe Pro Asn His Ser Phe Lys His Glu Asp Pro Met Gly 
                245                 250                 255     


Gln Gln Gly Ser Leu Gly Glu Gln Gln Tyr Ser Val Pro Pro Pro Val 
            260                 265                 270         


Tyr Gly Cys His Thr Pro Thr Asp Ser Cys Thr Gly Ser Gln Ala Leu 
        275                 280                 285             


Leu Leu Arg Thr Pro Tyr Ser Ser Asp Asn Leu Tyr Gln Met Thr Ser 
    290                 295                 300                 


Gln Leu Glu Cys Met Thr Trp Asn Gln Met Asn Leu Gly Ala Thr Leu 
305                 310                 315                 320 


Lys Gly Val Ala Ala Gly Ser Ser Ser Ser Val Lys Trp Thr Glu Gly 
                325                 330                 335     


Gln Ser Asn His Ser Thr Gly Tyr Glu Ser Asp Asn His Thr Thr Pro 
            340                 345                 350         


Ile Leu Cys Gly Ala Gln Tyr Arg Ile His Thr His Gly Val Phe Arg 
        355                 360                 365             


Gly Ile Gln Asp Val Arg Arg Val Pro Gly Val Ala Pro Thr Leu Val 
    370                 375                 380                 


Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr 
385                 390                 395                 400 


Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met His 
                405                 410                 415     


Ser Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys Asp 
            420                 425                 430         


Cys Glu Arg Arg Phe Ser Arg Ser Asp Gln Leu Lys Arg His Gln Arg 
        435                 440                 445             


Arg His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His Thr Gly 
465                 470                 475                 480 


Lys Thr Ser Glu Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys 
                485                 490                 495     


Lys Phe Ala Arg Ser Asp Glu Leu Val Arg His His Asn Met His Gln 
            500                 505                 510         


Arg Asn Met Thr Lys Leu Gln Leu Ala Leu 
        515                 520         


<210>  447
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Glu Lys Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr 
1               5                   10                  15      


Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe 
            20                  25                  30          


Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln 
        35                  40                  45              


Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser 
    50                  55                  60                  


Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp 
65                  70                  75                  80  


Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln 
                85                  90                  95      


Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala Gly Ser Ser Ser 
            100                 105                 110         


Ser Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser Thr Gly Tyr Glu 
        115                 120                 125             


Ser Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala Gln Tyr Arg Ile 
    130                 135                 140                 


His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val Arg Arg Val Pro 
145                 150                 155                 160 


Gly Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu Thr Ser Glu Lys 
                165                 170                 175     


Arg Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys 
            180                 185                 190         


Leu Ser His Leu Gln Met His Ser Arg Lys His Thr Gly Glu Lys Pro 
        195                 200                 205             


Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe Ser Arg Ser Asp 
    210                 215                 220                 


Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val Lys Pro Phe Gln 
225                 230                 235                 240 


Cys Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp His Leu Lys Thr 
                245                 250                 255     


His Thr Arg Thr His Thr Gly Glu Lys Pro Phe Ser Cys Arg Trp Pro 
            260                 265                 270         


Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu Val Arg His His 
        275                 280                 285             


Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu Ala Leu 
    290                 295                 300         


<210>  448
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Glu Lys Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr 
1               5                   10                  15      


Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe 
            20                  25                  30          


Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln 
        35                  40                  45              


Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser 
    50                  55                  60                  


Cys Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp 
65                  70                  75                  80  


Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln 
                85                  90                  95      


Met Asn Leu Gly Ala Thr Leu Lys Gly His Ser Thr Gly Tyr Glu Ser 
            100                 105                 110         


Asp Asn His Thr Thr Pro Ile Leu Cys Gly Ala Gln Tyr Arg Ile His 
        115                 120                 125             


Thr His Gly Val Phe Arg Gly Ile Gln Asp Val Arg Arg Val Pro Gly 
    130                 135                 140                 


Val Ala Pro Thr Leu Val Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg 
145                 150                 155                 160 


Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu 
                165                 170                 175     


Ser His Leu Gln Met His Ser Arg Lys His Thr Gly Glu Lys Pro Tyr 
            180                 185                 190         


Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe Ser Arg Ser Asp Gln 
        195                 200                 205             


Leu Lys Arg His Gln Arg Arg His Thr Gly Val Lys Pro Phe Gln Cys 
    210                 215                 220                 


Lys Thr Cys Gln Arg Lys Phe Ser Arg Ser Asp His Leu Lys Thr His 
225                 230                 235                 240 


Thr Arg Thr His Thr Gly Lys Thr Ser Glu Lys Pro Phe Ser Cys Arg 
                245                 250                 255     


Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asp Glu Leu Val Arg 
            260                 265                 270         


His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln Leu Ala Leu 
        275                 280                 285             


<210>  449
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
        35                  40                  45              


Gly Ile Asn Leu Asp Leu Gly Ser Gly Val Lys Val Lys Ile Ile Pro 
    50                  55                  60                  


Lys Glu Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln 
65                  70                  75                  80  


Val 
    


<210>  450
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Val Leu Gly Arg Glu Met Arg Asp Met Glu Gly Asp Leu Gln Glu Leu 
        35                  40                  45              


His Gln Ser Asn Thr Gly Asp Lys Ser Gly Phe Gly Phe Arg Arg Gln 
    50                  55                  60                  


Gly Glu Asp Asn Thr 
65                  


<210>  451
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  452
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  452

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


