                                                  SEQUENCE LISTING

<110>  Greve, Jeffrey
       Nagarajan, Niranjana
       Kim, JungMin
 
<120>  Multivalent regulatory T cell modulators

<130>  127754-00820

<150>  US 62/753,397
<151>  2018-10-31

<160>  1111    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2 N88R C125S mutant

<400>  1

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2 T3A, N88R, C125S mutant

<400>  3

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  4
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc N297A, T350V, L351Y, F405A, Y407V mutant

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  5
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc N297A, T350V, T366L, K392L, T394W mutant

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  7
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc 297A mutant

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  8
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc T366Y mutant

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  9
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc Y407T mutant

<400>  9

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     



<210>  10
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Fc fusion protein

<400>  10

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu 
305                 310                 315                 320 


Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly 
    370                 


<210>  11
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2 Fc fusion protein

<400>  11

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr 
    370                 


<210>  12
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2HeavyIL2vC

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asn Ser Asp Thr Arg Phe Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Thr Ser Ser Asp Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Ile Ile Ser Thr Leu Thr 
        595             


<210>  13
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4HeavyIL2vC

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Val Ser Gly Phe Ile Leu Thr Glu Leu 
            20                  25                  30          


Ser Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Trp Asp Phe His Phe Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
    450                 455                 460                 


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
465                 470                 475                 480 


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
                485                 490                 495     


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
            500                 505                 510         


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
        515                 520                 525             


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
    530                 535                 540                 


Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
545                 550                 555                 560 


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
                565                 570                 575     


Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile Ser Thr 
            580                 585                 590         


Leu Thr 
        


<210>  14
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2HeavyIL2vC(W)

<400>  14

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asn Ser Asp Thr Arg Phe Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Thr Ser Ser Asp Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Ile Ile Ser Thr Leu Thr 
        595             


<210>  15
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4HeavyIL2vC(W)

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Val Ser Gly Phe Ile Leu Thr Glu Leu 
            20                  25                  30          


Ser Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Trp Asp Phe His Phe Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr 
    450                 455                 460                 


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
465                 470                 475                 480 


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
                485                 490                 495     


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
            500                 505                 510         


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
        515                 520                 525             


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
    530                 535                 540                 


Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
545                 550                 555                 560 


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
                565                 570                 575     


Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile Ser Thr 
            580                 585                 590         


Leu Thr 
        


<210>  16
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2Heavy(V)

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asn Ser Asp Thr Arg Phe Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gly Thr Ser Ser Asp Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  17
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4Heavy(V)

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Val Ser Gly Phe Ile Leu Thr Glu Leu 
            20                  25                  30          


Ser Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Trp Asp Phe His Phe Asp Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  18
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2vCFc(V)

<400>  18

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr 
    370                 


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2Kappa

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Asp Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  20
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4Kappa

<400>  20

Asp Phe Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  21

Gly Gly Gly Gly Ser 
1               5   

<210>  22
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  22
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggttcag agcggggctg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttca gcagctacgc catcagctgg      180

gtgaggcagg cacccggcca gggcctggag tggatgggcg gcatcatccc catctttggc      240

actgccaact acgcccagaa gttccagggc agggtgacca tcacagccga cgagagcacc      300

tctaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaagagca tcctgggagg aaggatcttc ggcggctact tcgacctgtg gggtcgcggg      420

accctggtga ccgtgtcatc tgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  23
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  23

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Ile Leu Gly Gly Arg 
        115                 120                 125             


Ile Phe Gly Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  24
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  24
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacaccttta gcgactacta cgtgcactgg      180

gtgaggcaag cacccggtca gggcctggag tggatgggcg gcatcatccc catcgtgggc      240

accgccaact acgcccagaa gttccagggt agggtgacca tcaccgcaga cgagtctacc      300

agcaccgcgt acatggagct gagcagcctg aggagcgagg acaccgccgt ttactactgc      360

gccagggcag gtggcgggga ctacaagagc tactacttcg actattgggg caggggcacc      420

ctggtgaccg tgagctctgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  25
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  25

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Asp Tyr Tyr Val His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Val Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Gly Gly Asp Tyr 
        115                 120                 125             


Lys Ser Tyr Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  26
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  26
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agtggggcgg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggaaccttta gcagctacgc cttcagctgg      180

gtgcgacagg cccctggaca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

acccccaact acgcccagaa gttccaaggc cgggtgacca tcactgccga cgagagcacc      300

tccaccgcct acatggagct cagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggtga gggccaagag gcccaactgg tacttcgacc tgtggggcag gggcaccctc      420

gtgaccgtga gcagcgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  27
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  27

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Phe Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Pro Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Arg Ala Lys Arg Pro 
        115                 120                 125             


Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  28
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  28
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctcgtgcag agcggtgcgg aggtgaagaa gcccggcagc      120

agcgtgaagg taagctgcaa ggccagcggt ggcaccttca gcacctttgg cgtgagctgg      180

gtgaggcaag ccccaggcca aggcctggag tggatgggca ggatcatccc catcctggcc      240

accaccaact acgcccagaa gttccagggc agggtgacca tcaccgcaga cgagagcacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gcctctggcg actactatga cagctctggc tactacggct acttccagca ctggggccag      420

ggaaccctgg tgaccgttag ctccgccagc accaagggcc ccagcgtgtt ccctctggcc      480

cccagcagca agagcaccag cggcggaacc gccgccctgg gctgcctggt gaaggactac      540

ttccccgagc ccgtgaccgt gtcctggaac agcggcgctc tgaccagcgg agtgcacacc      600

ttccctgccg tgctgcagag cagcggcctg tactccctga gcagcgtggt gaccgtgccc      660

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc ctccaacacc      720

aaggtggaca agaaggtgga gcctaagagc tgcgacaaga cccacacctg ccctccctgc      780

cccgcccccg agctgctggg cggacccagc gtgttcctgt tccctcccaa gcccaaggac      840

accctgatga tcagccgcac ccccgaggtg acctgcgtgg tggtggacgt gagccacgag      900

gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg aggtgcacaa cgccaagacc      960

aagcctcggg aggagcagta caactccacc taccgcgtgg tgagcgtgct gaccgtgctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgagcaacaa ggccctgccc     1080

gctcccatcg agaagaccat cagcaaggcc aagggccagc cccgggagcc tcaggtgtac     1140

accctgcccc ccagccgcga agagatgacc aagaaccagg tgagcctgac ctgcctggtg     1200

aagggcttct acccctccga catcgccgtg gagtgggaga gcaacggcca gcctgagaac     1260

aactacaaga ccacccctcc cgtgctggac agcgacggca gcttcttcct gtacagcaag     1320

ctgaccgtgg acaagtcccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1380

gaggccctgc acaaccacta cacccagaag agcctgagcc tgagccccgg atagtaa        1437


<210>  29
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  29

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Thr Phe Gly Val Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Ile Pro Ile Leu Ala 
65                  70                  75                  80  


Thr Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Asp Tyr Tyr Asp Ser 
        115                 120                 125             


Ser Gly Tyr Tyr Gly Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475         


<210>  30
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  30
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggttca gctcctggag agcggcggag gtctggtgca gccagggggt      120

agcctgaggc tgagctgcgc cgcaagcggc ttcaccttca gcagctactg gatgagctgg      180

gtgaggcagg cacccggcaa gggcctggag tgggttagta gcattagcag cgacaccact      240

tacaagtact acgccgacag cgtgaagggc aggttcacga tcagcaggga caattctaag      300

aacaccctgt acctgcagat gaacagcctg cgagccgagg acaccgccgt gtactactgc      360

gccagggagg tggacactgc catgaagaac tggggccagg gcaccctggt gaccgttagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  31
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  31

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Asp Thr Thr 
65                  70                  75                  80  


Tyr Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Asp Thr Ala Met 
        115                 120                 125             


Lys Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  32
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  32
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctggaa agcggtggcg gcctcgtgaa gcccggtggg      120

agcctgaggc tgagctgcgc cgcaagcgga ttcacattca gcagctactg gatgagctgg      180

gtgcgccaag ccccaggaaa gggcctggag tgggtgagcg ccatcggcgg ctcaggggca      240

ggcacctact atgccgatag cgtgaagggc aggttcacca ttagcctgga cgacagcaag      300

aacaccctgt acctgcagat gaacagcctg aagaccgagg acaccgccgt gtactactgc      360

gccaggttga gcactgtgac caggggcttc gactactggg gccagggcac cctggtgaca      420

gttagctccg caagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  33
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  33

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Gly Gly Ser Gly Ala 
65                  70                  75                  80  


Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Thr Val Thr Arg 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  34
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  34
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgccg aggtgaagaa gcccggtgcg      120

agcgtaaagg tgagctgcaa ggccagcggc tacaccttca ccgacagcta catccattgg      180

gtgaggcagg cacccggcca gggcctggag tggatgggct ggatgaaccc caacagcggc      240

aacaccggct acgcccagaa gttccagggc agggtgacca tgaccaggga caccagcacc      300

tccaccgttt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggggcg tgttcgacta cggggactat ggctactact accactacat ggacgtgtgg      420

ggcaagggca ccacagtgac cgtgagctct gccagcacca agggccccag cgtgttccct      480

ctggccccca gcagcaagag caccagcggc ggaaccgccg ccctgggctg cctggtgaag      540

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gcgctctgac cagcggagtg      600

cacaccttcc ctgccgtgct gcagagcagc ggcctgtact ccctgagcag cgtggtgacc      660

gtgcccagca gcagcctggg cacccagacc tacatctgca acgtgaacca caagccctcc      720

aacaccaagg tggacaagaa ggtggagcct aagagctgcg acaagaccca cacctgccct      780

ccctgccccg cccccgagct gctgggcgga cccagcgtgt tcctgttccc tcccaagccc      840

aaggacaccc tgatgatcag ccgcaccccc gaggtgacct gcgtggtggt ggacgtgagc      900

cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc      960

aagaccaagc ctcgggagga gcagtacaac tccacctacc gcgtggtgag cgtgctgacc     1020

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgag caacaaggcc     1080

ctgcccgctc ccatcgagaa gaccatcagc aaggccaagg gccagccccg ggagcctcag     1140

gtgtacaccc tgccccccag ccgcgaagag atgaccaaga accaggtgag cctgacctgc     1200

ctggtgaagg gcttctaccc ctccgacatc gccgtggagt gggagagcaa cggccagcct     1260

gagaacaact acaagaccac ccctcccgtg ctggacagcg acggcagctt cttcctgtac     1320

agcaagctga ccgtggacaa gtcccggtgg cagcagggca acgtgttcag ctgcagcgtg     1380

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgag ccccggatag     1440

taa                                                                   1443


<210>  35
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  35

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp Ser Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Met Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Val Phe Asp Tyr Gly 
        115                 120                 125             


Asp Tyr Gly Tyr Tyr Tyr His Tyr Met Asp Val Trp Gly Lys Gly Thr 
    130                 135                 140                 


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 


<210>  36
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  36
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca actggtgcag agcggtgcgg aggtgaagaa gccgggagcc      120

agcgtgaagg tgagctgcaa agccagtggc ggcaccttta gcagctacgc catcagctgg      180

gtgaggcagg cccctgggca gggcctggag tggatgggct ggatcagccc cgacaacggc      240

aacaccaact acgcccagaa gctgcaggga cgagtgacca tgaccaggga caccagcact      300

agcaccgtgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggctgg cctacgacac cggctactac tattattact acatggacgt gtggggcaag      420

gggaccaccg tgaccgtgag ctctgccagc accaagggcc ccagcgtgtt ccctctggcc      480

cccagcagca agagcaccag cggcggaacc gccgccctgg gctgcctggt gaaggactac      540

ttccccgagc ccgtgaccgt gtcctggaac agcggcgctc tgaccagcgg agtgcacacc      600

ttccctgccg tgctgcagag cagcggcctg tactccctga gcagcgtggt gaccgtgccc      660

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc ctccaacacc      720

aaggtggaca agaaggtgga gcctaagagc tgcgacaaga cccacacctg ccctccctgc      780

cccgcccccg agctgctggg cggacccagc gtgttcctgt tccctcccaa gcccaaggac      840

accctgatga tcagccgcac ccccgaggtg acctgcgtgg tggtggacgt gagccacgag      900

gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg aggtgcacaa cgccaagacc      960

aagcctcggg aggagcagta caactccacc taccgcgtgg tgagcgtgct gaccgtgctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgagcaacaa ggccctgccc     1080

gctcccatcg agaagaccat cagcaaggcc aagggccagc cccgggagcc tcaggtgtac     1140

accctgcccc ccagccgcga agagatgacc aagaaccagg tgagcctgac ctgcctggtg     1200

aagggcttct acccctccga catcgccgtg gagtgggaga gcaacggcca gcctgagaac     1260

aactacaaga ccacccctcc cgtgctggac agcgacggca gcttcttcct gtacagcaag     1320

ctgaccgtgg acaagtcccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1380

gaggccctgc acaaccacta cacccagaag agcctgagcc tgagccccgg atagtaa        1437


<210>  37
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  37

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Pro Asp Asn Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ala Tyr Asp Thr Gly 
        115                 120                 125             


Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475         


<210>  38
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  38
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gctcctggag agcggcggtg gtctggtaca gcccggaggc      120

agcttgaggc tgagctgtgc cgccagcgga ttcgccttca gcagccactg gatgcactgg      180

gtgaggcaag caccaggtaa gggcctggag tgggttgcca ccatctctag cggaagccac      240

agcatccact acgcagacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcctg agggccgagg ataccgccgt ctactactgc      360

gccagggagg ccggcaccag ctattactac tacggcatgg acgtgtgggg caagggaacc      420

accgtgaccg tgagcagcgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  39
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  39

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Ala Phe Ser Ser His Trp Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Ser His 
65                  70                  75                  80  


Ser Ile His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Gly Thr Ser Tyr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  40
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  40
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggtgcag agcggagcgg aagtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttcg gctactacgc catcagctgg      180

gtgaggcagg ccccaggcca gggcctggag tggatgggcg gcatcatccc catggtgggc      240

accggccagt acgcccagga gttccagggc agggtgacca tcactgccga cgaaagcacc      300

agcaccgcat acatggagct gagcagtctg aggagcgagg acaccgccgt gtactactgc      360

gctggcgtgg aggtgggcgc gacacggggc tacttccagc actggggaca gggcaccctc      420

gtgaccgtga gcagcgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  41
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  41

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Gly Tyr Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Met Val Gly 
65                  70                  75                  80  


Thr Gly Gln Tyr Ala Gln Glu Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Val Glu Val Gly Ala Thr 
        115                 120                 125             


Arg Gly Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  42
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  42
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctcgtgcag agcggtgccg aggtgaagaa gccgggagcc      120

tctgtgaagg ttagctgcaa ggccagcggc ggtaccttca gcagctacgc catcagctgg      180

gtgaggcagg cacccggaca gggcctggag tggatgggct ggatcaaccc caactcaggc      240

gggaccaatt acgcccagaa gttccaaggc agggtgacca tgaccaggga cactagcacc      300

agcaccgtgt acatggagct tagcagcctg aggagcgagg acaccgccgt gtattactgc      360

gccatggata ccaactacta ctatggcatg gacgtgtggg gccagggcac aaccgtgacc      420

gtgagcagcg caagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  43
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  43

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Met Asp Thr Asn Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  44
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  44
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggttcag agcggtgccg aggtgaaaaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggt tacactttca ccggctacta catgcactgg      180

gtgaggcagg cccctggaca gggcctggag tggatgggca tcatcgaccc cagcggcgga      240

ggcaccagct acgcccagaa gttccagggc agggtaacca tgaccaggga cacctctacg      300

agcacagtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaaggaca tcgtggtagt gcctgccgcc atcgccaact actattacgg catggacgtg      420

tggggccaag gcacaaccgt gaccgtgagc tctgccagca ccaagggccc cagcgtgttc      480

cctctggccc ccagcagcaa gagcaccagc ggcggaaccg ccgccctggg ctgcctggtg      540

aaggactact tccccgagcc cgtgaccgtg tcctggaaca gcggcgctct gaccagcgga      600

gtgcacacct tccctgccgt gctgcagagc agcggcctgt actccctgag cagcgtggtg      660

accgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

tccaacacca aggtggacaa gaaggtggag cctaagagct gcgacaagac ccacacctgc      780

cctccctgcc ccgcccccga gctgctgggc ggacccagcg tgttcctgtt ccctcccaag      840

cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt ggtggacgtg      900

agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      960

gccaagacca agcctcggga ggagcagtac aactccacct accgcgtggt gagcgtgctg     1020

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gagcaacaag     1080

gccctgcccg ctcccatcga gaagaccatc agcaaggcca agggccagcc ccgggagcct     1140

caggtgtaca ccctgccccc cagccgcgaa gagatgacca agaaccaggt gagcctgacc     1200

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagag caacggccag     1260

cctgagaaca actacaagac cacccctccc gtgctggaca gcgacggcag cttcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gagccccgga     1440

tagtaa                                                                1446


<210>  45
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  45

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asp Pro Ser Gly Gly 
65                  70                  75                  80  


Gly Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Ile Val Val Val Pro 
        115                 120                 125             


Ala Ala Ile Ala Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
    130                 135                 140                 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


<210>  46
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  46
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tctggtgctg aggtgaagaa gcccggcagc      120

agcgtaaagg tgagctgcaa ggccagcggc tacaccttca ccgattatta catgcactgg      180

gtgaggcagg caccgggtca aggcctggag tggatgggcg gcatcatgcc cctgtttggc      240

accatcaagt acgcccagga actgcagggc agggtgacca tcacagccga cgagtcaacc      300

agcaccgcgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggggaa gagtgggcgc caccgactac tggggccagg gcaccttggt gaccgtaagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  47
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  47

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Met Pro Leu Phe Gly 
65                  70                  75                  80  


Thr Ile Lys Tyr Ala Gln Glu Leu Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Val Gly Ala Thr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  48
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  48
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtacag tccggtgctg aggtgaagaa gcccggcagc      120

agcgtaaagg tgagctgcaa ggccagcggc tacaccttca ccagctacgg aatcagctgg      180

gtgaggcagg cacccggaca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgcaaact acgcccccag gttccagggc agggtgacca tcaccgccga tgaaagcacc      300

agcactgcct acatggagct gagcagcctg aggagcgagg acactgctgt gtactactgc      360

gccagggaca cggtgtcaat ggacgtgtgg ggccaaggca ccaccgtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  49
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  49

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Pro Arg Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Thr Val Ser Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  50
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  50
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgcgg aggtgaagaa gcctggcagc      120

agcgtaaagg tgagctgcaa ggccagcggt ggcaccttca gcagctacgc cattagctgg      180

gtgaggcagg cacctggtca gggcctggag tggatgggcg gcatcatccc catgttcggc      240

accaccaact acgcccagaa gttccagggc agggtgacca tcaccgccga cgagagcacc      300

tctactgcct acatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gccaccgtgg ccgctgccgg tcctaactgg tacttcgacc tgtggggaag ggggaccctg      420

gtgaccgtga gctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  51
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  51

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Met Phe Gly 
65                  70                  75                  80  


Thr Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Val Ala Ala Ala Gly Pro 
        115                 120                 125             


Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  52
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  52
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggtgcaa agcggtgccg aggtgaagaa acccggagcg      120

agcgtgaaag tgagctgcaa ggccagcggc tacaccttca ccagccacta catgcactgg      180

gtgaggcagg caccgggcca aggcctggag tggatgggca tcatcaaccc ttcaggcggc      240

agcacctcct acgcccagaa gttccagggc agggtgacca tgaccaggga cacctctacc      300

agcaccgtgt acatggagct gagcagcctg aggtctgagg acaccgccgt ctactactgc      360

gccagggccg gaatcggcta ccttgccgcc cacgacctgt actattacta cggcatggac      420

gtgtggggga ggggaaccct ggtgaccgtg agctctgcca gcaccaaggg ccccagcgtg      480

ttccctctgg cccccagcag caagagcacc agcggcggaa ccgccgccct gggctgcctg      540

gtgaaggact acttccccga gcccgtgacc gtgtcctgga acagcggcgc tctgaccagc      600

ggagtgcaca ccttccctgc cgtgctgcag agcagcggcc tgtactccct gagcagcgtg      660

gtgaccgtgc ccagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      720

ccctccaaca ccaaggtgga caagaaggtg gagcctaaga gctgcgacaa gacccacacc      780

tgccctccct gccccgcccc cgagctgctg ggcggaccca gcgtgttcct gttccctccc      840

aagcccaagg acaccctgat gatcagccgc acccccgagg tgacctgcgt ggtggtggac      900

gtgagccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac      960

aacgccaaga ccaagcctcg ggaggagcag tacaactcca cctaccgcgt ggtgagcgtg     1020

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgagcaac     1080

aaggccctgc ccgctcccat cgagaagacc atcagcaagg ccaagggcca gccccgggag     1140

cctcaggtgt acaccctgcc ccccagccgc gaagagatga ccaagaacca ggtgagcctg     1200

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gagcaacggc     1260

cagcctgaga acaactacaa gaccacccct cccgtgctgg acagcgacgg cagcttcttc     1320

ctgtacagca agctgaccgt ggacaagtcc cggtggcagc agggcaacgt gttcagctgc     1380

agcgtgatgc acgaggccct gcacaaccac tacacccaga agagcctgag cctgagcccc     1440

ggatagtaa                                                             1449


<210>  53
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  53

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser His Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Ile Gly Tyr Leu 
        115                 120                 125             


Ala Ala His Asp Leu Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Arg 
    130                 135                 140                 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210>  54
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  54
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggcag aggtgaagaa gcctggcgcg      120

tctgtgaagg tgagctgcaa ggccagcggc tacacgttca ccgacagctt catgttctgg      180

gtgaggcagg cacccggcca gggcctggag tgggtgggcc tgatcaaccc cggcaccgga      240

gccaccatct tcgcccagaa gttccagggc agggtgacca tgacccgcga cacctctacg      300

agcaccgttt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gcccgatcct cagactacga cagcagcgac tattggggcc aaggcactct ggtgaccgtg      420

agctccgcaa gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  55
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  55

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp Ser Phe Met Phe Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Val Gly Leu Ile Asn Pro Gly Thr Gly 
65                  70                  75                  80  


Ala Thr Ile Phe Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ser Asp Tyr Asp Ser 
        115                 120                 125             


Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  56
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  56
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggcag aggtgaagaa gcccggcagc      120

caagtgaagg tgagctgcaa ggccagcggc tacactttca ccagtttcgg tatcagctgg      180

gtgaggcagg ccccaggcca gggcctggag tggctgggcg gcatcatccc caccctgggc      240

accgccaact acgcccagaa gttccagggc agggtgacca tcactgccga cgacagcacg      300

agcaccgcat acatggagct gagcagcctg aggagcgagg acaccgccgt gtactattgc      360

gcaggcggag ccgcagcagg acctgacaag tattacggca tggacgtgtg gggccaaggc      420

accaccgtga ccgtgagctc tgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  57
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  57

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Gln Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Phe Gly Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Leu Gly Gly Ile Ile Pro Thr Leu Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Asp Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Gly Ala Ala Ala Gly Pro 
        115                 120                 125             


Asp Lys Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  58
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  58
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtcca gctgctggag agcggcggag gactggtgca gccaggcggt      120

tctctgcgac tgagctgcgc ggcaagcgga ttcagcttca gccacgcctg gatgagctgg      180

gtgaggcagg cacccggcaa gggcctggag tgggttagcg tgatccacag tggcggcagc      240

accttctacg ccgacagcgt gaagggcagg ttcaccatca gcagggacaa cagcaagaac      300

accctgtacc tgcagatgaa cagcctgagg gccgaggaca ccgccgtgta ctactgcgcc      360

aggatcggaa agggaggggg attcgattat tggggccagg gcaccctggt gaccgtgagc      420

agcgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  59
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  59

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Ser Phe Ser His Ala Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile His Ser Gly Gly Ser 
65                  70                  75                  80  


Thr Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile Gly Lys Gly Gly Gly Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  60
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  60
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctggag agcggcgcag aagtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagtggc ggcaccttta gctcctacgc catcagctgg      180

gtgaggcagg cacccggaca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgctaact acgcccagaa gttccagggc agggtgacca tcaccgccga cgagagcact      300

agtaccgcct atatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gccagcggct tctacagcaa cgacctgtac tattactact acatggacgt gtggggcaag      420

ggcaccaccg tgaccgtgag ctctgccagc accaagggcc ccagcgtgtt ccctctggcc      480

cccagcagca agagcaccag cggcggaacc gccgccctgg gctgcctggt gaaggactac      540

ttccccgagc ccgtgaccgt gtcctggaac agcggcgctc tgaccagcgg agtgcacacc      600

ttccctgccg tgctgcagag cagcggcctg tactccctga gcagcgtggt gaccgtgccc      660

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc ctccaacacc      720

aaggtggaca agaaggtgga gcctaagagc tgcgacaaga cccacacctg ccctccctgc      780

cccgcccccg agctgctggg cggacccagc gtgttcctgt tccctcccaa gcccaaggac      840

accctgatga tcagccgcac ccccgaggtg acctgcgtgg tggtggacgt gagccacgag      900

gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg aggtgcacaa cgccaagacc      960

aagcctcggg aggagcagta caactccacc taccgcgtgg tgagcgtgct gaccgtgctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgagcaacaa ggccctgccc     1080

gctcccatcg agaagaccat cagcaaggcc aagggccagc cccgggagcc tcaggtgtac     1140

accctgcccc ccagccgcga agagatgacc aagaaccagg tgagcctgac ctgcctggtg     1200

aagggcttct acccctccga catcgccgtg gagtgggaga gcaacggcca gcctgagaac     1260

aactacaaga ccacccctcc cgtgctggac agcgacggca gcttcttcct gtacagcaag     1320

ctgaccgtgg acaagtcccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1380

gaggccctgc acaaccacta cacccagaag agcctgagcc tgagccccgg atagtaa        1437


<210>  61
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  61

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Phe Tyr Ser Asn Asp 
        115                 120                 125             


Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475         


<210>  62
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  62
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggcgctg aggtgaagaa gcccggagcc      120

agcgtgaaag tgagctgcaa ggcctcaggc tacaccttca gcaaccacta catgcactgg      180

gtgaggcagg ccccaggcca gggcctggag tggatgggct gggtcaaccc caccagcggc      240

aacaccggat acgcccagaa gttccagggc agggtgacca tgacccggga caccagtacc      300

tccaccgtgt atatggagct gagcagcttg aggagcgagg acaccgccgt gtactactgc      360

gccagggacc tgggggtgac gtatttcgac ctgtggggaa ggggcaccct ggtgaccgtg      420

agctctgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  63
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  63

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Asn His Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Val Asn Pro Thr Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Gly Val Thr Tyr 
        115                 120                 125             


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  64
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  64
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctggag agcggcggtg gcctggtgca gcccggtggc      120

agcctgcggc tgagctgcgc tgcaagcggc ttcaagttca ggaccttctg gatgaactgg      180

gttaggcagg cacccggcaa gggcctggag tgggtgagcg tgatcagcaa cggcggagac      240

gccacccatt atgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aataccctgt acctgcagat gaacagcctc agggccgagg acaccgctgt gtactactgc      360

gccagggtgg actgctccgg cggtagctgc tatctgggct actggggcca gggaaccttg      420

gtgacagtca gcagcgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  65
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  65

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Lys Phe Arg Thr Phe Trp Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Ser Asn Gly Gly Asp 
65                  70                  75                  80  


Ala Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Cys Ser Gly Gly 
        115                 120                 125             


Ser Cys Tyr Leu Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  66
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  66
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gcttttggag agtggcggtg gccttgtgaa gcctggcggg      120

agcctgaggc tgagctgtgc cgccagcggc tttacatttt ccagttactg gatgcattgg      180

gtgaggcagg ccccaggcaa gggcctcgag tgggtaagca gcattagcag caggagcagc      240

tacatttact acgccgacag cgtgaagggc aggttcacca tcagcaggga tgacagcaag      300

aacaccctgt acctgcagat gaacagcctg aaaaccgagg acaccgccgt gtactactgc      360

gccagggagg gcaacggaat ggacgtgtgg ggccagggca ccacggtgac tgttagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  67
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  67

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Arg Ser Ser 
65                  70                  75                  80  


Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Asn Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  68
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  68
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggttcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg ttagctgcaa ggccagtggc ggcaccttca gcagctacgc cataagctgg      180

gtgaggcagg cacccggaca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgctaact acgcccagaa attccagggt agggtgacca tcactgccga cgagagcacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaagacac ccctgggaag gggatatggc ctgttcgact actggggcca gggcaccctg      420

gtgaccgtgt ctagcgcaag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  69
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  69

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Thr Pro Leu Gly Arg Gly 
        115                 120                 125             


Tyr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  70
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  70
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtacag agcggagccg aagtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttca gcaactacgc catcagctgg      180

gtgaggcaag cccctgggca gggcctggag tggatgggct ggatcagcgc ctacaacggc      240

aacaccaatt acgcccagaa gttccagggc cgagtgacca tgaccaggga cacaagcacc      300

agcaccgtgt acatggagct gagcagcctg aggagcgagg acaccgctgt gtactactgc      360

gccaggagca ccaacgcctt ggactactgg ggccagggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  71
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  71

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Asn Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Asn Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  72
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  72
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agtggggccg aggtgaagaa acccggcagc      120

agcgttaagg tgagctgcaa ggccagcggc tacaccttca gcgattacta catgcactgg      180

gtgaggcagg cacccggcca gggcctggag tggatgggcg gcatcctgcc cgtgttcggc      240

accgccacat acgcccagaa gttccagggg agggtgacca tcacggccga cgaaagcacc      300

tcaacagcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggggct tcggctattt cgactactgg gggcagggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  73
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  73

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Asp Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Leu Pro Val Phe Gly 
65                  70                  75                  80  


Thr Ala Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Phe Gly Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  74
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  74
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agtggagccg aggtgaagaa gcccggagcc      120

tctgtaaagg taagctgcaa ggccagcggc tacaccttca ccggccagta catgcactgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggca tcatcaaccc cagcggggga      240

agcaccagtt acgcccagaa gttccaggga agggtgacca tgaccaggga caccagcaca      300

agcacggtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccggaagct actaccccta ctactattac ggcatggacg tgtggggcca gggcacgacc      420

gtgacagtga gctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  75
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  75

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Gly Gln Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Ser Tyr Tyr Pro Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  76
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  76
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagtggc ggcaccttcg gcaattacgg cataaactgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggcg gcatcatccc cgtgttcggc      240

accaccaact acgcccagaa gttccaggga agggtgacca tcaccgcgga cgagagcacc      300

tcaaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtattactgc      360

gccaggggcc tcaggtacta ctacgggatg gacgtgtggg gccagggcac aaccgtgacc      420

gtgagctctg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  77
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  77

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Gly Asn Tyr Gly Ile Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Val Phe Gly 
65                  70                  75                  80  


Thr Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Leu Arg Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  78
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  78
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggttcag agcggagctg aggtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtacgttca ccggctactt catacactgg      180

gtgaggcagg cccctggaca aggcctggag tggatgggct ggatgaaccc caacagcggc      240

aacacaggct acgcccagaa gttccaggga agggtgacca tgaccaggga caccagtacc      300

agcacagtgt acatggagct gtccagcctg aggagcgagg ataccgccat gtattactgc      360

gccagggagg gccaaggcgt ggtgcccgtg gactactggg gacagggcac actggtgacc      420

gtgagctctg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  79
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  79

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Thr Gly Tyr Phe Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Met Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly Gln Gly Val Val 
        115                 120                 125             


Pro Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  80
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  80
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tccggagccg aagtgaagaa gcccggcagc      120

agcgtgaaag tgagctgcaa ggcgagcggc tacaccttca ccacctatgg catcacctgg      180

gtgaggcagg ccccaggaca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgccaact acgcccagaa gttccaaggc agggtgacca tcaccgcgga tgagagtacc      300

agtaccgcat acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaaactgt ctggctccag cggctcatgg gactactatt actactacgg catggacgtg      420

tggggccagg gcacactggt gaccgtgagc tctgccagca ccaagggccc cagcgtgttc      480

cctctggccc ccagcagcaa gagcaccagc ggcggaaccg ccgccctggg ctgcctggtg      540

aaggactact tccccgagcc cgtgaccgtg tcctggaaca gcggcgctct gaccagcgga      600

gtgcacacct tccctgccgt gctgcagagc agcggcctgt actccctgag cagcgtggtg      660

accgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

tccaacacca aggtggacaa gaaggtggag cctaagagct gcgacaagac ccacacctgc      780

cctccctgcc ccgcccccga gctgctgggc ggacccagcg tgttcctgtt ccctcccaag      840

cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt ggtggacgtg      900

agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      960

gccaagacca agcctcggga ggagcagtac aactccacct accgcgtggt gagcgtgctg     1020

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gagcaacaag     1080

gccctgcccg ctcccatcga gaagaccatc agcaaggcca agggccagcc ccgggagcct     1140

caggtgtaca ccctgccccc cagccgcgaa gagatgacca agaaccaggt gagcctgacc     1200

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagag caacggccag     1260

cctgagaaca actacaagac cacccctccc gtgctggaca gcgacggcag cttcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gagccccgga     1440

tagtaa                                                                1446


<210>  81
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  81

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Thr Tyr Gly Ile Thr Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Ser Gly Ser Ser Gly 
        115                 120                 125             


Ser Trp Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


<210>  82
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  82
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggaaccttta gcacctacgc cttcagctgg      180

gtgaggcagg ccccaggcca gggcctggag tacatgggcg gcatcatccc catgttcggc      240

accgccaact acgcccagaa gttccagggc agggtgacca tcaccgcgga cgaaagcacc      300

agtaccgcgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gctggcgaga ggggctacgg gtcactggac tactggggac agggaaccct ggtgaccgtg      420

agctctgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  83
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  83

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Thr Tyr Ala Phe Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Tyr Met Gly Gly Ile Ile Pro Met Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Glu Arg Gly Tyr Gly Ser 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  84
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  84
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gctcctggag agcggcggtg gccttgtgca gcccggtggc      120

agcctgcgcc tgagttgcgc ggcaagcggc ttcaccttca gcaacagcga catgaattgg      180

gttaggcagg cccctggtaa gggcctggag tgggtgagct tcattagcag tagcagcgga      240

tacacctact acgccgacag cgtgaagggg aggttcacca tcagcaggga caacagcaag      300

aataccctgt acctgcagat gaacagcctg agggccgagg ataccgccgt gtattactgc      360

gccagggcca acaacaactg gaacttctac ttcgactact ggggccaggg aaccctggtg      420

accgtgagca gcgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  85
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  85

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Asn Ser Asp Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Phe Ile Ser Ser Ser Ser Gly 
65                  70                  75                  80  


Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Asn Asn Asn Trp Asn 
        115                 120                 125             


Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  86
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  86
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tccggagcgg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc gacaccttcg acacgtacgc catcagctgg      180

gtgaggcagg ccccaggcca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgccaact acgcccagaa gttccagggc agggttacca tcaccgcaga cgagagcacc      300

tccaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggagcc gaggaagggg gtacagctac ggcagcggcc tgttcgacta ctggggacag      420

ggaaccctgg tgaccgtgag ctctgccagc accaagggcc ccagcgtgtt ccctctggcc      480

cccagcagca agagcaccag cggcggaacc gccgccctgg gctgcctggt gaaggactac      540

ttccccgagc ccgtgaccgt gtcctggaac agcggcgctc tgaccagcgg agtgcacacc      600

ttccctgccg tgctgcagag cagcggcctg tactccctga gcagcgtggt gaccgtgccc      660

agcagcagcc tgggcaccca gacctacatc tgcaacgtga accacaagcc ctccaacacc      720

aaggtggaca agaaggtgga gcctaagagc tgcgacaaga cccacacctg ccctccctgc      780

cccgcccccg agctgctggg cggacccagc gtgttcctgt tccctcccaa gcccaaggac      840

accctgatga tcagccgcac ccccgaggtg acctgcgtgg tggtggacgt gagccacgag      900

gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg aggtgcacaa cgccaagacc      960

aagcctcggg aggagcagta caactccacc taccgcgtgg tgagcgtgct gaccgtgctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgagcaacaa ggccctgccc     1080

gctcccatcg agaagaccat cagcaaggcc aagggccagc cccgggagcc tcaggtgtac     1140

accctgcccc ccagccgcga agagatgacc aagaaccagg tgagcctgac ctgcctggtg     1200

aagggcttct acccctccga catcgccgtg gagtgggaga gcaacggcca gcctgagaac     1260

aactacaaga ccacccctcc cgtgctggac agcgacggca gcttcttcct gtacagcaag     1320

ctgaccgtgg acaagtcccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1380

gaggccctgc acaaccacta cacccagaag agcctgagcc tgagccccgg atagtaa        1437


<210>  87
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  87

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Asp Thr Phe Asp Thr Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Arg Gly Arg Gly Tyr 
        115                 120                 125             


Ser Tyr Gly Ser Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475         


<210>  88
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  88
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgccg aggtgaagaa gccgggagcg      120

agtgtgaaag ttagctgcaa ggccagcggc cagaccttca ccgactacgc aatcaactgg      180

gtgaggcagg ccccaggaca gggcctggaa tggatgggct ggatgaaccc caacagcggc      240

aacaccggct acgcccagaa gttccagggc agggtgacaa tgaccaggga cacttcaacc      300

agcacagtgt acatggagct gagcagcctg cggtcagagg ataccgccgt gtactactgc      360

gccagggaga ccctggagca acagctgccc ttcgactact ggggacaagg caccctggtg      420

accgtgagct ccgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  89
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  89

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gln Thr Phe Thr Asp Tyr Ala Ile Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Met Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Thr Leu Glu Gln Gln 
        115                 120                 125             


Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  90
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  90
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgccg aggtgaagaa gcccggtgcc      120

agtgtgaagg tgagctgcaa ggccagcgcc tacaccttta ccagctacgg catcagctgg      180

ctgaggcagg cacccggcca gggcctggag tggatgggct ggatcaaccc caacagcggc      240

aacaccggct acgcccacaa gtttcagggc agggtgacca tgaccaggga caccagcaca      300

agcaccgtct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gcccgaggcg gcagcggctg gcccacctgg ggacagggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  91
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  91

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Ala Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Leu Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala His Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Ser Gly Trp Pro 
        115                 120                 125             


Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  92
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  92
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgccg aggtgaagaa gcccggtgcg      120

agcgtgaaag tgagctgcaa ggccagcggt tacaccttca cgagctacgg catcagctgg      180

gtgaggcagg cacccggaca gggcctggag tggatgggct ggatcgaccc caacagtggc      240

ggcaccaact acgcccagaa gttccagggg agggtgacca tgaccaggga taccagcacc      300

tccaccgtgt atatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gccagggacg attggttcag cggcgacctg gactactggg gccagggcac gcttgtgacc      420

gtaagctctg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  93
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  93

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asp Pro Asn Ser Gly 
65                  70                  75                  80  


Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Asp Trp Phe Ser Gly 
        115                 120                 125             


Asp Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  94
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  94
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctggag agcggtggcg gcctggtgca acccggtggc      120

tcactgaggc tgagctgcgc ggctagcggc ttcaccttca ccgacgcctg gatgaactgg      180

gtgaggcagg cacctggcaa gggcctggag tgggtgtcta ccatcagcgt tagcgtgggc      240

gtgacctact atgccgactc cgtgaaaggc aggtttacta tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcttg agggccgagg acaccgccgt gtactactgc      360

gccaccatcg gcagcatggc cactatccga aagggcgcca ctgacgcctt tgacatctgg      420

ggccagggca ccctggtgac cgtgagcagc gccagcacca agggccccag cgtgttccct      480

ctggccccca gcagcaagag caccagcggc ggaaccgccg ccctgggctg cctggtgaag      540

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gcgctctgac cagcggagtg      600

cacaccttcc ctgccgtgct gcagagcagc ggcctgtact ccctgagcag cgtggtgacc      660

gtgcccagca gcagcctggg cacccagacc tacatctgca acgtgaacca caagccctcc      720

aacaccaagg tggacaagaa ggtggagcct aagagctgcg acaagaccca cacctgccct      780

ccctgccccg cccccgagct gctgggcgga cccagcgtgt tcctgttccc tcccaagccc      840

aaggacaccc tgatgatcag ccgcaccccc gaggtgacct gcgtggtggt ggacgtgagc      900

cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc      960

aagaccaagc ctcgggagga gcagtacaac tccacctacc gcgtggtgag cgtgctgacc     1020

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgag caacaaggcc     1080

ctgcccgctc ccatcgagaa gaccatcagc aaggccaagg gccagccccg ggagcctcag     1140

gtgtacaccc tgccccccag ccgcgaagag atgaccaaga accaggtgag cctgacctgc     1200

ctggtgaagg gcttctaccc ctccgacatc gccgtggagt gggagagcaa cggccagcct     1260

gagaacaact acaagaccac ccctcccgtg ctggacagcg acggcagctt cttcctgtac     1320

agcaagctga ccgtggacaa gtcccggtgg cagcagggca acgtgttcag ctgcagcgtg     1380

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgag ccccggatag     1440

taa                                                                   1443


<210>  95
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  95

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Thr Asp Ala Trp Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Val Ser Val Gly 
65                  70                  75                  80  


Val Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Ile Gly Ser Met Ala Thr 
        115                 120                 125             


Ile Arg Lys Gly Ala Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 


<210>  96
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  96
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtccag agcggtgcgg aagtgaagaa gcccggcagc      120

agcgtgaagg taagctgcaa ggccagcggc ggaaccttca gcagctacgc catcagctgg      180

gtgaggcagg cccctggtca gggactggag tggatgggca ccatcatccc catgttcggc      240

atcgccgact acgcccagaa gttccaggga agggtgacca tcaccgcaga cgagagcacg      300

agtaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gctcgaagca gcaggagcag ctcctggtac aactggtact tcgacctgtg gggcaggggc      420

accctggtga ccgtgagctc tgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  97
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  97

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Thr Ile Ile Pro Met Phe Gly 
65                  70                  75                  80  


Ile Ala Asp Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ser Arg Ser Ser Ser 
        115                 120                 125             


Trp Tyr Asn Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  98
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  98
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca actggtgcag agcggagcag aagtgaagaa gcccggcagc      120

agcgtgaaag tgagctgcaa ggccagcggc tacaccttca ccagctacta catgcagtgg      180

gtgaggcagg ctcctggcca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgctaact acgcccagaa gttccagggc agggtgacca taaccgccga tgagagcact      300

agcactgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggcca ggtttggggc cgtagactac tgggggcaag gcaccctggt gaccgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  99
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  99

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met Gln Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Arg Phe Gly Ala Val 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  100
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  100
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggttcag agcggtgcgg aagtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa agccagcggc tacactttca cctcttatta catccactgg      180

gtgaggcagg cccctggaca gggcctggaa tggatgggca tcatcaaccc cagcgccgac      240

accaccacct acgcccagca gttccagggc agggtgacca tgaccaggga cacctctacc      300

agcactgtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggaccc caggcaatta tggcggcaac tccctgggct actactatta ctacggcatg      420

gacgtgtggg gccagggaac actggtgact gtgagctctg ccagcaccaa gggccccagc      480

gtgttccctc tggcccccag cagcaagagc accagcggcg gaaccgccgc cctgggctgc      540

ctggtgaagg actacttccc cgagcccgtg accgtgtcct ggaacagcgg cgctctgacc      600

agcggagtgc acaccttccc tgccgtgctg cagagcagcg gcctgtactc cctgagcagc      660

gtggtgaccg tgcccagcag cagcctgggc acccagacct acatctgcaa cgtgaaccac      720

aagccctcca acaccaaggt ggacaagaag gtggagccta agagctgcga caagacccac      780

acctgccctc cctgccccgc ccccgagctg ctgggcggac ccagcgtgtt cctgttccct      840

cccaagccca aggacaccct gatgatcagc cgcacccccg aggtgacctg cgtggtggtg      900

gacgtgagcc acgaggaccc cgaggtgaag ttcaactggt acgtggacgg cgtggaggtg      960

cacaacgcca agaccaagcc tcgggaggag cagtacaact ccacctaccg cgtggtgagc     1020

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgagc     1080

aacaaggccc tgcccgctcc catcgagaag accatcagca aggccaaggg ccagccccgg     1140

gagcctcagg tgtacaccct gccccccagc cgcgaagaga tgaccaagaa ccaggtgagc     1200

ctgacctgcc tggtgaaggg cttctacccc tccgacatcg ccgtggagtg ggagagcaac     1260

ggccagcctg agaacaacta caagaccacc cctcccgtgc tggacagcga cggcagcttc     1320

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1380

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc     1440

cccggatagt aa                                                         1452


<210>  101
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  101

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Ala Asp 
65                  70                  75                  80  


Thr Thr Thr Tyr Ala Gln Gln Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Pro Gly Asn Tyr Gly 
        115                 120                 125             


Gly Asn Ser Leu Gly Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
    130                 135                 140                 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
145                 150                 155                 160 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                165                 170                 175     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            180                 185                 190         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        195                 200                 205             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    210                 215                 220                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
225                 230                 235                 240 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  102
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  102
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtccaa tccggtgccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacacattca ccgactacca gatgcactgg      180

gtgaggcagg cacccggaca gggcctggag tgggtgggcg tgatcaaccc cggtggaggc      240

agcaccacct acgcccagac cttccagggc agggtgacca tcaccgccga cgagagcacc      300

tcaaccgcct acatggagct gagcagcctg aggagcgagg acaccgctgt gtactactgc      360

gccaggggag gcgtggagta cagctctagc tgggattact attactacta tggcatggac      420

gtgtggggac aaggtaccac agtgaccgtg agctctgcca gcaccaaggg ccccagcgtg      480

ttccctctgg cccccagcag caagagcacc agcggcggaa ccgccgccct gggctgcctg      540

gtgaaggact acttccccga gcccgtgacc gtgtcctgga acagcggcgc tctgaccagc      600

ggagtgcaca ccttccctgc cgtgctgcag agcagcggcc tgtactccct gagcagcgtg      660

gtgaccgtgc ccagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      720

ccctccaaca ccaaggtgga caagaaggtg gagcctaaga gctgcgacaa gacccacacc      780

tgccctccct gccccgcccc cgagctgctg ggcggaccca gcgtgttcct gttccctccc      840

aagcccaagg acaccctgat gatcagccgc acccccgagg tgacctgcgt ggtggtggac      900

gtgagccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac      960

aacgccaaga ccaagcctcg ggaggagcag tacaactcca cctaccgcgt ggtgagcgtg     1020

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgagcaac     1080

aaggccctgc ccgctcccat cgagaagacc atcagcaagg ccaagggcca gccccgggag     1140

cctcaggtgt acaccctgcc ccccagccgc gaagagatga ccaagaacca ggtgagcctg     1200

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gagcaacggc     1260

cagcctgaga acaactacaa gaccacccct cccgtgctgg acagcgacgg cagcttcttc     1320

ctgtacagca agctgaccgt ggacaagtcc cggtggcagc agggcaacgt gttcagctgc     1380

agcgtgatgc acgaggccct gcacaaccac tacacccaga agagcctgag cctgagcccc     1440

ggatagtaa                                                             1449


<210>  103
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  103

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp Tyr Gln Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Val Gly Val Ile Asn Pro Gly Gly Gly 
65                  70                  75                  80  


Ser Thr Thr Tyr Ala Gln Thr Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Val Glu Tyr Ser 
        115                 120                 125             


Ser Ser Trp Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210>  104
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  104
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgccg aggtgaagaa gcctggcgcc      120

tcagtaaagg tgagctgcaa ggccagcggc tacaccttca acagccactg ggtgcattgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggct ggatcagcgc ctacaacggc      240

aacaccaact acgcccagaa gctgcagggc agggtgacca tgaccaggga caccagcacc      300

tccacggtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gcctccggcg actaccccta ttactactac ggcatggacg tgtggggcca gggcaccacc      420

gtgaccgtga gctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  105
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  105

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Asn Ser His Trp Val His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Asp Tyr Pro Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  106
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  106
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggcgctc aggtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggc tacactttca gcagctacta tatccactgg      180

gtgaggcaag cgccaggaca gggcctggaa tggatgggct ggatcaaccc ccacagcggc      240

ggaaccaatt acggccagga gttccagggg agggtgacca tgaccaggga caccagtacc      300

agcaccgtct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gctagggaca gcagcggaat gggtgccacc atcggctact gggggcaggg caccctggtg      420

accgttagca gtgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  107
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  107

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Gln Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Ser Tyr Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro His Ser Gly 
65                  70                  75                  80  


Gly Thr Asn Tyr Gly Gln Glu Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Ser Gly Met Gly 
        115                 120                 125             


Ala Thr Ile Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  108
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  108
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgcttgag tccggcggag gcctggtgaa acccggaggt      120

agcctgaggc tgagctgtgc ggccagcggc ttcaccttca gcagctactg gatgagctgg      180

gtcaggcagg cccctggcaa gggcctggag tgggtgagcg ctatcagcgg caccgccatc      240

aacacctact acgccgatag cgtgaagggc aggttcacca ttagcaggga cgacagcaag      300

aacaccctgt acctgcagat gaacagcctg aagaccgagg acacagccgt gtactactgc      360

gccagggtgc ggagggattc ctcaggtggt ggggctttcg acatctgggg ccagggcacg      420

atggtcaccg tgtcaagcgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  109
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  109

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Thr Ala Ile 
65                  70                  75                  80  


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Arg Arg Asp Ser Ser 
        115                 120                 125             


Gly Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  110
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  110
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtacag agcggagcgg aagtgaagaa gcccggcagc      120

agcgtgaagg ttagctgcaa ggccagcggt ggcaccttca gcagctacgc catcagctgg      180

gtgaggcaag ccccaggaca gggcctggaa tggatgggcg gcatcgtgcc catcttcgag      240

accgccaact acgcccagaa gttccaaggc agggtgacca tcacagccga cgagagcacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggaca cccccaactt cgactactgg ggccagggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  111
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  111

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Val Pro Ile Phe Glu 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Thr Pro Asn Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  112
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  112
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctcgag agcggcggtg gcctggtgaa gcccggaggc      120

agcctgaggc tgagctgtgc cgccagcggt ttcacattca gcagctactg gatgagctgg      180

gtgaggcagg ctccgggaaa gggcctggag tgggttagca gcatcagcgg caccagcaac      240

tatatgtact acgccgacag cgtgaagggc aggttcacca tcagcaggga cgacagcaag      300

aacaccctgt acctgcagat gaacagcttg aagaccgagg acaccgctgt gtattactgc      360

gccagggacc ggggttttct gggctacttt gactactggg gccagggcac ccttgttaca      420

gtgagctctg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  113
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  113

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Thr Ser Asn 
65                  70                  75                  80  


Tyr Met Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Phe Leu Gly 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  114
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  114
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcaa agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg taagctgcaa ggccagcggt tacacgttca ccaattacta catgcactgg      180

gtgaggcagg ccccaggcca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

actgccaact acgcccagaa gttccagggc agggtgacca tcaccgccga cgagagcact      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgcagt gtactactgc      360

gccaggggag gctattacga cagcagtcag ttcgacatct gggggcaagg cacaatggtg      420

accgtgagct ctgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  115
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  115

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Tyr Tyr Asp Ser 
        115                 120                 125             


Ser Gln Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  116
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  116
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctgcag agcggaggcg gactggtgca gcccggtggt      120

agtctgaggc tgagctgcgc cgcaagcgag ttcaccttca gcaacgcctg gatgagctgg      180

gtgaggcagg cccctggcaa gggcctggag tgggtaagca ccatcagcgg caccagcagg      240

tacacctact acgccgacag cgtgaagggc aggttcacca ttagcaggga caacagcaag      300

aacagcctct acttgcagat gaatagcctg agggccgagg acaccgccgt gtactactgc      360

gccagggacc aggacggaag gctggactac tggggccagg gcaccctggt gaccgtgagc      420

agcgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  117
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  117

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Gln Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Glu Phe Thr Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Thr Ser Arg 
65                  70                  75                  80  


Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Asp Gly Arg Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  118
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  118
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcaa agcggtgcgg aggtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccctga gcagctacgc cataagctgg      180

gtgaggcagg cacccggaca gggcctggag tggatgggcg gcatcagccc ctacaacggc      240

aaagccaact acgccgagaa actgcagggc agggtgacca tgaccaggga caccagcacc      300

tcaaccgtgt atatggagct gagctccctg aggagcgagg acaccgccgt ctactactgt      360

gccatcagga gcatcgccgc cagggagggc gtatattact actacatgga cgtgtggggc      420

aagggcacca ccgtgaccgt gagctctgcc agcaccaagg gccccagcgt gttccctctg      480

gcccccagca gcaagagcac cagcggcgga accgccgccc tgggctgcct ggtgaaggac      540

tacttccccg agcccgtgac cgtgtcctgg aacagcggcg ctctgaccag cggagtgcac      600

accttccctg ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgaccgtg      660

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gccctccaac      720

accaaggtgg acaagaaggt ggagcctaag agctgcgaca agacccacac ctgccctccc      780

tgccccgccc ccgagctgct gggcggaccc agcgtgttcc tgttccctcc caagcccaag      840

gacaccctga tgatcagccg cacccccgag gtgacctgcg tggtggtgga cgtgagccac      900

gaggaccccg aggtgaagtt caactggtac gtggacggcg tggaggtgca caacgccaag      960

accaagcctc gggaggagca gtacaactcc acctaccgcg tggtgagcgt gctgaccgtg     1020

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtgagcaa caaggccctg     1080

cccgctccca tcgagaagac catcagcaag gccaagggcc agccccggga gcctcaggtg     1140

tacaccctgc cccccagccg cgaagagatg accaagaacc aggtgagcct gacctgcctg     1200

gtgaagggct tctacccctc cgacatcgcc gtggagtggg agagcaacgg ccagcctgag     1260

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctgtacagc     1320

aagctgaccg tggacaagtc ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1380

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc cggatagtaa     1440


<210>  119
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  119

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Leu Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ser Pro Tyr Asn Gly 
65                  70                  75                  80  


Lys Ala Asn Tyr Ala Glu Lys Leu Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ile Arg Ser Ile Ala Ala Arg 
        115                 120                 125             


Glu Gly Val Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  120
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  120
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggcag aggtgaagaa gcccggagcc      120

agcgtgaagg tgagctgcaa ggccagcgga gcggctttca acactgtggc catcagctgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggct ggatgaaccc caacagcggc      240

aacaccggct acgcccagaa gtttcagggc agggtgacca tgaccaggga caccagcacc      300

agtaccgttt acatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gccaggaccc ccgctgctgc aggaactgtg tatttcgact actggggcca gggcaccctg      420

gtgaccgtga gctccgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  121
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  121

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Ala Ala Phe Asn Thr Val Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Met Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Pro Ala Ala Ala Gly 
        115                 120                 125             


Thr Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  122
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  122
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggtccag tccggcgcag aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa agccagtggc ggcagcttca gcaggagcag catcagctgg      180

gtgaggcaag caccgggtca gggcctggag tggatgggcg gcatcatccc catcttcgga      240

gcccccgttt acgcccagga cctgcaagga agagtgacca ttaccgccga tgagagcacg      300

agcaccgcct atatggagct gagcagcctg aggagcgagg acaccgctgt gtactactgc      360

gccagggacc acccccattg tagcagcacc agctgttact acggcatgga cgtgtggggc      420

caaggcacca ccgtgaccgt gagctctgcc agcaccaagg gccccagcgt gttccctctg      480

gcccccagca gcaagagcac cagcggcgga accgccgccc tgggctgcct ggtgaaggac      540

tacttccccg agcccgtgac cgtgtcctgg aacagcggcg ctctgaccag cggagtgcac      600

accttccctg ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgaccgtg      660

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gccctccaac      720

accaaggtgg acaagaaggt ggagcctaag agctgcgaca agacccacac ctgccctccc      780

tgccccgccc ccgagctgct gggcggaccc agcgtgttcc tgttccctcc caagcccaag      840

gacaccctga tgatcagccg cacccccgag gtgacctgcg tggtggtgga cgtgagccac      900

gaggaccccg aggtgaagtt caactggtac gtggacggcg tggaggtgca caacgccaag      960

accaagcctc gggaggagca gtacaactcc acctaccgcg tggtgagcgt gctgaccgtg     1020

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtgagcaa caaggccctg     1080

cccgctccca tcgagaagac catcagcaag gccaagggcc agccccggga gcctcaggtg     1140

tacaccctgc cccccagccg cgaagagatg accaagaacc aggtgagcct gacctgcctg     1200

gtgaagggct tctacccctc cgacatcgcc gtggagtggg agagcaacgg ccagcctgag     1260

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctgtacagc     1320

aagctgaccg tggacaagtc ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1380

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc cggatagtaa     1440


<210>  123
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  123

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Ser Phe Ser Arg Ser Ser Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Ala Pro Val Tyr Ala Gln Asp Leu Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp His Pro His Cys Ser 
        115                 120                 125             


Ser Thr Ser Cys Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  124
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  124
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggttcag agcggtgccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttca gcaattacgc catcagctgg      180

gtgaggcaag cgcctggcca aggcctggag tggatgggct ggatcagcgc ttacaacggc      240

aacaccaact acgcccagaa gttccagggc agggtgacca tcaccgccga cgaaagcacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgctgt gtactactgc      360

gccaggctgt ccaccgttac caccaggccc tactactatt atggcatgga cgtgtggggg      420

caaggcacca ccgtgacagt gagctctgcc agcaccaagg gccccagcgt gttccctctg      480

gcccccagca gcaagagcac cagcggcgga accgccgccc tgggctgcct ggtgaaggac      540

tacttccccg agcccgtgac cgtgtcctgg aacagcggcg ctctgaccag cggagtgcac      600

accttccctg ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgaccgtg      660

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gccctccaac      720

accaaggtgg acaagaaggt ggagcctaag agctgcgaca agacccacac ctgccctccc      780

tgccccgccc ccgagctgct gggcggaccc agcgtgttcc tgttccctcc caagcccaag      840

gacaccctga tgatcagccg cacccccgag gtgacctgcg tggtggtgga cgtgagccac      900

gaggaccccg aggtgaagtt caactggtac gtggacggcg tggaggtgca caacgccaag      960

accaagcctc gggaggagca gtacaactcc acctaccgcg tggtgagcgt gctgaccgtg     1020

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtgagcaa caaggccctg     1080

cccgctccca tcgagaagac catcagcaag gccaagggcc agccccggga gcctcaggtg     1140

tacaccctgc cccccagccg cgaagagatg accaagaacc aggtgagcct gacctgcctg     1200

gtgaagggct tctacccctc cgacatcgcc gtggagtggg agagcaacgg ccagcctgag     1260

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctgtacagc     1320

aagctgaccg tggacaagtc ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1380

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc cggatagtaa     1440


<210>  125
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  125

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Asn Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser Thr Val Thr Thr 
        115                 120                 125             


Arg Pro Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  126
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  126
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggtgcaa agcggcgcag aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttca gcagctacgc cattagctgg      180

gtgaggcagg cacctggcca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgccaact acgcccagaa gttccagggc agggtgacca tcactgccga cgagagcacc      300

agcaccgcgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgt      360

gccagagtgc cagccgatta ctattattac tactatggca tggacgtgtg gggccagggt      420

acaaccgtga ccgtgagctc tgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  127
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  127

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Pro Ala Asp Tyr Tyr 
        115                 120                 125             


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  128
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  128
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctggag agcggaggcg gcctggtgca gccaggcggg      120

agcctgaggc tgagctgtgc cgccagcggg ttcaccgtta gctccaacta catgagctgg      180

gtgaggcagg cccctggtaa gggcctggag tgggtgtcag ccatcagcgg ctctggtggc      240

tccacctatt acgccgacag cgtgaaaggg aggttcacaa tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcctt cgggccgagg acaccgccgt gtactactgc      360

gcgaggggca ggttcggcag ccgagatgtg tggggaaagg gcaccaccgt gaccgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  129
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  129

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Phe Gly Ser Arg 
        115                 120                 125             


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  130
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  130
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gcttgtgcag agcggtgcgg aggtgaagaa gcccggcagc      120

agcgtaaagg tgagctgcaa ggccagcggc ggtaccttca gcagctacgc catcagctgg      180

gtgaggcagg cacccggcca aggcctggag tggatgggcg acatcatccc cgtgatcgac      240

accaccaact acgcccagaa gttccaaggc agggtgacca tcaccgccga cgaaagcacc      300

agcaccgcct acatggagct gagcagcctg aggtctgaag acactgccgt gtactactgc      360

gctagggcga gcggctaccc cttcggcagg tggttcgacc cctggggcca gggcaccctg      420

gtgaccgtgt cctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  131
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  131

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Asp Ile Ile Pro Val Ile Asp 
65                  70                  75                  80  


Thr Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Ser Gly Tyr Pro Phe 
        115                 120                 125             


Gly Arg Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  132
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  132
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctcgag agcggcggtg gcctggtgaa gcctggcggc      120

agcctgagac tgagctgcgc tgcgagcgga ttcaccttca gcagctacgc catgagctgg      180

gtgcgacagg cccctggaaa gggcctggag tgggtgagca gcattagcag cgacagctac      240

tacaagtacc acgccgacag cgtgaagggt aggttcacca tcagcaggga cgacagcaag      300

aacaccctgt acctgcagat gaacagcttg aagaccgagg acaccgcagt gtactactgc      360

gccaagggcg cagactacga cttctggagc ggctacctgg actactgggg ccagggcacc      420

ttggtgaccg tgagctctgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  133
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  133

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Asp Ser Tyr 
65                  70                  75                  80  


Tyr Lys Tyr His Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Ala Asp Tyr Asp Phe 
        115                 120                 125             


Trp Ser Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  134
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  134
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tctggggccg aagtgaagaa gcccggagca      120

agcgtgaagg tgagctgcaa ggccagcgga tacaccttta ccggctacta catgcactgg      180

gtgaggcagg ctcccggtca gggcctggag tggatgggcg tgatcaaccc cagcggtggc      240

agcaccagtt acgcccagaa gttccagggc cgagtgacca tgaccaggga caccagtacc      300

agcacagtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggggag attactacta tggctccggc agcgactatt actattatta cggcatggac      420

gtgtggggcc agggcaccct ggtgaccgtg agctctgcca gcaccaaggg ccccagcgtg      480

ttccctctgg cccccagcag caagagcacc agcggcggaa ccgccgccct gggctgcctg      540

gtgaaggact acttccccga gcccgtgacc gtgtcctgga acagcggcgc tctgaccagc      600

ggagtgcaca ccttccctgc cgtgctgcag agcagcggcc tgtactccct gagcagcgtg      660

gtgaccgtgc ccagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag      720

ccctccaaca ccaaggtgga caagaaggtg gagcctaaga gctgcgacaa gacccacacc      780

tgccctccct gccccgcccc cgagctgctg ggcggaccca gcgtgttcct gttccctccc      840

aagcccaagg acaccctgat gatcagccgc acccccgagg tgacctgcgt ggtggtggac      900

gtgagccacg aggaccccga ggtgaagttc aactggtacg tggacggcgt ggaggtgcac      960

aacgccaaga ccaagcctcg ggaggagcag tacaactcca cctaccgcgt ggtgagcgtg     1020

ctgaccgtgc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgagcaac     1080

aaggccctgc ccgctcccat cgagaagacc atcagcaagg ccaagggcca gccccgggag     1140

cctcaggtgt acaccctgcc ccccagccgc gaagagatga ccaagaacca ggtgagcctg     1200

acctgcctgg tgaagggctt ctacccctcc gacatcgccg tggagtggga gagcaacggc     1260

cagcctgaga acaactacaa gaccacccct cccgtgctgg acagcgacgg cagcttcttc     1320

ctgtacagca agctgaccgt ggacaagtcc cggtggcagc agggcaacgt gttcagctgc     1380

agcgtgatgc acgaggccct gcacaaccac tacacccaga agagcctgag cctgagcccc     1440

ggatagtaa                                                             1449


<210>  135
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  135

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp Tyr Tyr Tyr Gly 
        115                 120                 125             


Ser Gly Ser Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
    130                 135                 140                 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210>  136
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  136
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctcgag agtggtgccg aagtcaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggt ggcacattca gcagctacgc catcagctgg      180

gtgaggcagg cccctggtca gggcttggaa tggatgggcg gcatcatccc catctttggc      240

accgcaaact acgcccagaa gttccagggc agggtgacca tcaccgccga caagagcacc      300

agcacagcct acatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gccaggccca ggctggccgt ggccggaggg tggtacttcg acctgtgggg cagaggcacc      420

ctggtgaccg ttagctctgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  137
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  137

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Arg Leu Ala Val Ala 
        115                 120                 125             


Gly Gly Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  138
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  138
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtcca gctgttggag agcggcggtg gcgtggtgca gcctggcagg      120

agcctgcgac tgagctgtgc cgccagcggc ttcaccttct ccagctactg gatgagctgg      180

gtaaggcagg cgccagggaa gggcctggag tgggtgagca gcatcagtag cgacagcagc      240

tataagtact acgcggacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcttg agggcagaag acactgccgt gtactactgc      360

gcccgagacg gcctgcgctg ggacgccttc gacatctggg gccagggcac aatggtgact      420

gtgagctctg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  139
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  139

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Asp Ser Ser 
65                  70                  75                  80  


Tyr Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Leu Arg Trp Asp 
        115                 120                 125             


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  140
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  140
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggctg aggtgaagaa gcctggcgca      120

agcgtgaaag tgagctgcaa ggccagcggc tacaccttca ccgaccacta cctgcactgg      180

gtgaggcagg cccctggcca aggcctggag tggatgggca tcatcaaccc cagcggaggc      240

tataccagcc acgcccagaa gttccagggc agggtgacca tgaccaggga cacctccacc      300

agcaccgtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtattactgc      360

gcccgagata ggttcaggga gctgctgggc agcaggtact acggcatgga cgtgtggggg      420

caaggcacca ccgtgaccgt gagctctgcc agcaccaagg gccccagcgt gttccctctg      480

gcccccagca gcaagagcac cagcggcgga accgccgccc tgggctgcct ggtgaaggac      540

tacttccccg agcccgtgac cgtgtcctgg aacagcggcg ctctgaccag cggagtgcac      600

accttccctg ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgaccgtg      660

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gccctccaac      720

accaaggtgg acaagaaggt ggagcctaag agctgcgaca agacccacac ctgccctccc      780

tgccccgccc ccgagctgct gggcggaccc agcgtgttcc tgttccctcc caagcccaag      840

gacaccctga tgatcagccg cacccccgag gtgacctgcg tggtggtgga cgtgagccac      900

gaggaccccg aggtgaagtt caactggtac gtggacggcg tggaggtgca caacgccaag      960

accaagcctc gggaggagca gtacaactcc acctaccgcg tggtgagcgt gctgaccgtg     1020

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtgagcaa caaggccctg     1080

cccgctccca tcgagaagac catcagcaag gccaagggcc agccccggga gcctcaggtg     1140

tacaccctgc cccccagccg cgaagagatg accaagaacc aggtgagcct gacctgcctg     1200

gtgaagggct tctacccctc cgacatcgcc gtggagtggg agagcaacgg ccagcctgag     1260

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctgtacagc     1320

aagctgaccg tggacaagtc ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1380

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc cggatagtaa     1440


<210>  141
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  141

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp His Tyr Leu His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly 
65                  70                  75                  80  


Tyr Thr Ser His Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Phe Arg Glu Leu 
        115                 120                 125             


Leu Gly Ser Arg Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  142
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  142
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgcgg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttca gcaactacgc catcagctgg      180

gtgaggcagg ccccaggcca gggcctggag tggatgggcg gcatcatccc cgtgttcggc      240

accgccacct acgcccagaa gttccaggga agggtgacca tcaccgccga cgaaagcact      300

agcactgcct acatggagct gagcagcctg aggagcgagg acacagccgt gtactactgc      360

gccagggtta ccgcaatggg cgtgggctgg tacttcgacc tgtggggcag gggcaccctg      420

gtgactgtta gctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  143
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  143

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Asn Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Val Phe Gly 
65                  70                  75                  80  


Thr Ala Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Thr Ala Met Gly Val 
        115                 120                 125             


Gly Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  144
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  144
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaagtgca gctggtgcag agtggggccg aggtgaaaaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacatcttca ccaactattg gattcaatgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggcg gcatcatccc catcttcgag      240

accgcgaact atgcccagaa gttccagggt cgcgttacca tcaccgccga cgacagcaca      300

agcaccgcct acatggagct gagcagcctg aggtccgagg acaccgcagt gtactactgc      360

gccaggctcg gcgatcgagg cgactttgac tactggggcc agggcaccct ggtgaccgtg      420

agctctgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  145
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  145

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Ile Phe Thr Asn Tyr Trp Ile Gln Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Glu 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Asp Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Asp Arg Gly Asp 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  146
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  146
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcaa agcggtgcag aagtgaagaa gcccggcagc      120

agcgtaaagg tgagctgcaa ggccagtggc ggaaccttca gctccgacgc catcaactgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggcg gcatcgtgcc cgcgtttggc      240

accgcaaact acgcccagaa gttccagggt agggtgacca tcaccgctga cgagagtacc      300

agcaccgcct acatggagtt gagcagcctg aggagcgagg acaccgccgt gtactattgc      360

gccaggagca gcagttcctg gccatactat tactactata tggacgtgtg gggcaagggc      420

accaccgtga ccgtgagctc tgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  147
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  147

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Asp Ala Ile Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Val Pro Ala Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ser Ser Ser Trp Pro 
        115                 120                 125             


Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  148
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  148
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtccag agcggagcgg aagtaaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacttcttca ccagctacgg catcagctgg      180

gtgaggcagg ccccaggaca gggcctggag tggatgggcg gagtgatccc catcagcggc      240

actgccaact atgcccagag cttccaaggc agggtgacca tcacagccga cgagagcacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggacg agaacggggc ctttgacatc tgggggcagg gcaccaccgt gaccgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  149
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  149

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Phe Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Val Ile Pro Ile Ser Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Ser Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Glu Asn Gly Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  150
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  150
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcaa agtggcgccg aagtgaagaa gcccggctca      120

agcgtgaaag tgagctgcaa ggccagcggc ggaaccttca gcagctacgc catcagctgg      180

gtgaggcaag cccctggcca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

actgccaact acgcccagaa gttccagggc agggtgacca tcaccgcgga tgagagcacc      300

tcaaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggaca accccgactt cgactactgg gggcaaggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  151
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  151

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Asn Pro Asp Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  152
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  152
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agtggggccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggt ggcaccttct caagcaacgc catcagctgg      180

gtgaggcagg cacccggcca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgccaact acgcccagaa gttccagggc agggtgacca tcaccgcaga tgagtcaacc      300

agcaccgcgt acatggagct cagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccggtagcc ccaccggcac tcccagggtg gtgttcgact actggggcca aggcacgttg      420

gtgactgtga gcagcgcaag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  153
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  153

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Asn Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Ser Pro Thr Gly Thr Pro 
        115                 120                 125             


Arg Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  154
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  154
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggcgcag aggtgaagaa gcccggagca      120

agcgtgaaag tgagctgcaa ggccagcggc ggaaccttca gcagctacgc catcagctgg      180

gtgaggcagg caccaggtca gggcctggag tggatgggca ggattaaccc caacagcgga      240

ggcaccgtgt atgcccagaa gttccagggc agggtgacca tgacacgcga cacctctact      300

agcactgtgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggaca ccagcatcgc cgctaggctc aatcccgact attactacta ttatggcatg      420

gacgtgtggg gacagggcac caccgtgacc gtgagctctg ccagcaccaa gggccccagc      480

gtgttccctc tggcccccag cagcaagagc accagcggcg gaaccgccgc cctgggctgc      540

ctggtgaagg actacttccc cgagcccgtg accgtgtcct ggaacagcgg cgctctgacc      600

agcggagtgc acaccttccc tgccgtgctg cagagcagcg gcctgtactc cctgagcagc      660

gtggtgaccg tgcccagcag cagcctgggc acccagacct acatctgcaa cgtgaaccac      720

aagccctcca acaccaaggt ggacaagaag gtggagccta agagctgcga caagacccac      780

acctgccctc cctgccccgc ccccgagctg ctgggcggac ccagcgtgtt cctgttccct      840

cccaagccca aggacaccct gatgatcagc cgcacccccg aggtgacctg cgtggtggtg      900

gacgtgagcc acgaggaccc cgaggtgaag ttcaactggt acgtggacgg cgtggaggtg      960

cacaacgcca agaccaagcc tcgggaggag cagtacaact ccacctaccg cgtggtgagc     1020

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgagc     1080

aacaaggccc tgcccgctcc catcgagaag accatcagca aggccaaggg ccagccccgg     1140

gagcctcagg tgtacaccct gccccccagc cgcgaagaga tgaccaagaa ccaggtgagc     1200

ctgacctgcc tggtgaaggg cttctacccc tccgacatcg ccgtggagtg ggagagcaac     1260

ggccagcctg agaacaacta caagaccacc cctcccgtgc tggacagcga cggcagcttc     1320

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1380

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc     1440

cccggatagt aa                                                         1452


<210>  155
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  155

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Thr Ser Ile Ala Ala 
        115                 120                 125             


Arg Leu Asn Pro Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
    130                 135                 140                 


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
145                 150                 155                 160 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                165                 170                 175     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            180                 185                 190         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        195                 200                 205             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    210                 215                 220                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
225                 230                 235                 240 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly 
        


<210>  156
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  156
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggcag aggtgaagaa gcccggcagc      120

agcgttaagg taagctgcaa ggccagcggg ggaaccttca gcagctacgc catcagctgg      180

gtgaggcagg cacccggcca gggcctggag tggatgggcg gcatcatccc cgtggtgggc      240

agccccgact acgcccagag gttccagggc agggtgacca tcactgccga cgagagcaca      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggcaca gcatcgtggg cgccaccgcc accagcatgg acgtgtgggg caagggcacc      420

accgtgaccg tgagctctgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  157
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  157

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Val Val Gly 
65                  70                  75                  80  


Ser Pro Asp Tyr Ala Gln Arg Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Ser Ile Val Gly Ala 
        115                 120                 125             


Thr Ala Thr Ser Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  158
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  158
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca actggtgcag agcggtgcgg aggtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggc tacaccttta gcgactacta cgtgcactgg      180

gtgaggcagg ctcctggaca gggcctggag tggatgggct ggatcagcgc atacaacggc      240

aacaccaact acgcccagaa gctgcagggc agggtgacca tgaccaggga caccagcact      300

agcaccgtgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggggga gcttggacat ctggttcagg gagcccggag tgtacatgga cgtgtggggc      420

aagggcacca ccgtgaccgt gagctctgcc agcaccaagg gccccagcgt gttccctctg      480

gcccccagca gcaagagcac cagcggcgga accgccgccc tgggctgcct ggtgaaggac      540

tacttccccg agcccgtgac cgtgtcctgg aacagcggcg ctctgaccag cggagtgcac      600

accttccctg ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgaccgtg      660

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gccctccaac      720

accaaggtgg acaagaaggt ggagcctaag agctgcgaca agacccacac ctgccctccc      780

tgccccgccc ccgagctgct gggcggaccc agcgtgttcc tgttccctcc caagcccaag      840

gacaccctga tgatcagccg cacccccgag gtgacctgcg tggtggtgga cgtgagccac      900

gaggaccccg aggtgaagtt caactggtac gtggacggcg tggaggtgca caacgccaag      960

accaagcctc gggaggagca gtacaactcc acctaccgcg tggtgagcgt gctgaccgtg     1020

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtgagcaa caaggccctg     1080

cccgctccca tcgagaagac catcagcaag gccaagggcc agccccggga gcctcaggtg     1140

tacaccctgc cccccagccg cgaagagatg accaagaacc aggtgagcct gacctgcctg     1200

gtgaagggct tctacccctc cgacatcgcc gtggagtggg agagcaacgg ccagcctgag     1260

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctgtacagc     1320

aagctgaccg tggacaagtc ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1380

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc cggatagtaa     1440


<210>  159
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  159

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Asp Tyr Tyr Val His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Leu Asp Ile Trp 
        115                 120                 125             


Phe Arg Glu Pro Gly Val Tyr Met Asp Val Trp Gly Lys Gly Thr Thr 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  160
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  160
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggtgcag agtggggcgg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacgctttca ccgactactt cattcactgg      180

gtgaggcagg ctcccggcca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgctaact acgcccagaa gttccagggc agggtgacca tcaccgccga caagagcacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgctgt gtactactgc      360

gccagggtgg cctacggcgc attcgacatc tggggccagg gaacgatggt aaccgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  161
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  161

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Ala Phe Thr Asp Tyr Phe Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Ala Tyr Gly Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  162
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  162
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagctg aagtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttca gcaactacgg cgtgtcatgg      180

gtgaggcagg cccctggaca gggtctggag tggatgggcg gcatcaaccc cagcaggggc      240

accaccacat acgcccagaa gttccagggc agggtgacca tgaccaggga caccagtacc      300

agcaccgtgt atatggaact gagcagcctg aggagcgagg acaccgcagt gtactactgc      360

gccaagggcg acatcgtggt agtacccgca gccatgttca gcctgggtcc cggctactac      420

tattacatgg acgtgtgggg caagggaacc acagtgaccg tgagctctgc cagcaccaag      480

ggccccagcg tgttccctct ggcccccagc agcaagagca ccagcggcgg aaccgccgcc      540

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgtcctg gaacagcggc      600

gctctgacca gcggagtgca caccttccct gccgtgctgc agagcagcgg cctgtactcc      660

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      720

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggagcctaa gagctgcgac      780

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggacc cagcgtgttc      840

ctgttccctc ccaagcccaa ggacaccctg atgatcagcc gcacccccga ggtgacctgc      900

gtggtggtgg acgtgagcca cgaggacccc gaggtgaagt tcaactggta cgtggacggc      960

gtggaggtgc acaacgccaa gaccaagcct cgggaggagc agtacaactc cacctaccgc     1020

gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc     1080

aaggtgagca acaaggccct gcccgctccc atcgagaaga ccatcagcaa ggccaagggc     1140

cagccccggg agcctcaggt gtacaccctg ccccccagcc gcgaagagat gaccaagaac     1200

caggtgagcc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg     1260

gagagcaacg gccagcctga gaacaactac aagaccaccc ctcccgtgct ggacagcgac     1320

ggcagcttct tcctgtacag caagctgacc gtggacaagt cccggtggca gcagggcaac     1380

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg     1440

agcctgagcc ccggatagta a                                               1461


<210>  163
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  163

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Asn Tyr Gly Val Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Asn Pro Ser Arg Gly 
65                  70                  75                  80  


Thr Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Ile Val Val Val 
        115                 120                 125             


Pro Ala Ala Met Phe Ser Leu Gly Pro Gly Tyr Tyr Tyr Tyr Met Asp 
    130                 135                 140                 


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
145                 150                 155                 160 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
                165                 170                 175     


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
            180                 185                 190         


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
        195                 200                 205             


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
    210                 215                 220                 


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
225                 230                 235                 240 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
                245                 250                 255     


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            260                 265                 270         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    290                 295                 300                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
305                 310                 315                 320 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                325                 330                 335     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    370                 375                 380                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
385                 390                 395                 400 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                405                 410                 415     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            420                 425                 430         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    450                 455                 460                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
465                 470                 475                 480 


Ser Leu Ser Pro Gly 
                485 


<210>  164
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  164
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggttca actgctcgag agcggtggcg gcctggtgca acccggaggc      120

agcctgaggc tgagctgcgc cgcaagcggc ttcaccttca gcagctatgg catgagctgg      180

gtgaggcagg cacccggcaa aggcctggag tggctggccg tgatctggag cgacggcgga      240

cacaagtact acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcctg cgggcagagg acaccgccgt gtactactgc      360

gccagggagg tgcgaggctg gttcgacccc tggggccagg gcaccctggt gaccgtgagc      420

agcgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  165
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  165

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Leu Ala Val Ile Trp Ser Asp Gly Gly 
65                  70                  75                  80  


His Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Arg Gly Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  166
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  166
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca acttctggag agcggtggcg ggctggtgca gccgggaggc      120

agcctgaggc tgagctgtgc cgccagcggc ttcgccttca gcagccactg gatgcactgg      180

gtgaggcagg ccccaggcaa aggcttggag tgggtggccg tgatcagcta cgacggcagc      240

aacaagtact acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagtctg agggccgagg acaccgccgt gtactactgc      360

gccagggacc gcggcatgat cgattattgg ggccagggca ccctggtgac cgtgagcagc      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  167
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  167

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Ala Phe Ser Ser His Trp Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser 
65                  70                  75                  80  


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Met Ile Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  168
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  168
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gctcctggag agcggtggcg gtctggtcca gcctggcggt      120

agcctgcgcc tgagctgtgc cgccagcggc ttcaccttca gcagctactg gatgagctgg      180

gtaaggcagg cccctggcaa gggcctcgaa tgggtgagca gcatttcaag cagtagcagt      240

tacatctact acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagtctg agggccgagg acaccgccgt gtactactgc      360

gccagggacc agggctggtt cgacccctgg ggccagggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  169
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  169

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Gly Trp Phe Asp 
        115                 120                 125             


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  170
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  170
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctggag agcggtggcg gcctggtgca gcacggcggt      120

agtctcaggc tgagctgcgc ggcaagcggc ttcaccttca gcagctactg gatgagctgg      180

gtgaggcagg ctcccggaaa gggcctggag tgggtgtcta gcatcagcag tagcagttct      240

tacatctact acgccgacag cgtgaagggc aggttcacca tttccaggga taacagcaaa      300

aacaccctgt acctgcagat gaacagcctg cgagccgaag acactgcggt gtactactgc      360

gccagggaca tcgccggcta cttcgacctg tggggcaggg gcaccctggt cactgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  171
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  171

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln His Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ile Ala Gly Tyr Phe 
        115                 120                 125             


Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  172
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  172
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggcag aggtgaagaa gccaggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tataccttta ccgactacta catgcactgg      180

gtgaggcaag cacccgggca aggactggag tggatgggcg tgatcatccc cgtgctgggc      240

gcagcaaagt acgcccagaa gttccagggc agggtgacca tcaccgcaga cgagtccacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaagggct ggggcgcatt cgacatctgg ggccagggga cgatggttac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  173
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  173

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Val Ile Ile Pro Val Leu Gly 
65                  70                  75                  80  


Ala Ala Lys Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Gly Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  174
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  174
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

tctgtaaagg tgagctgcaa ggccagcggc tacaccttca gcgaccacta catacactgg      180

gtgaggcagg cccctggaca gggcctggag tggatgggcg gcatcatccc catcctgggc      240

acagccaact acgcccagaa gttccaaggc agggtgacca ttacggcgga cgaatctacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaccgaca tcgccgttgc gggaactggg ttcgactact ggggccaggg caccttggtg      420

accgtgagca gtgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  175
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  175

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Asp His Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Leu Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Ile Ala Val Ala Gly 
        115                 120                 125             


Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  176
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  176
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggttca gctgctggag agcggtggcg gcctggtgca gcccggtggt      120

agcctgcgcc tgagctgtgc cgccagcgac ttcaacttca agaacgcctg gatgagctgg      180

gtaaggcagg ccccaggtaa gggcctggag tgggtgagcg ccattagcgg caatggggca      240

ggcacctact acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcctg agagccgaag acaccgccgt gtactactgc      360

gccagggtgg gcgagaccgg cgcattcgac atctggggac agggcaccac cgtgaccgtg      420

agcagcgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  177
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  177

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Asp Phe Asn Phe Lys Asn Ala Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Ala 
65                  70                  75                  80  


Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Glu Thr Gly Ala 
        115                 120                 125             


Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  178
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  178
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggagca      120

agcgtgaaag tgagctgcaa ggccagcggg ggtaccttca gcaactacgg attcagctgg      180

gtgaggcagg cccctggaca gggcctggag tggatgggct ggatcagcgc ctacaacggc      240

aacaccaatt atgcccagca gctccagggc agggtgacca tgaccaggga cacaagcacc      300

agtaccgtgt acatggagtt gagcagcctg aggagcgagg acaccgccgt gtattactgc      360

gccaagggcg actacggcga gacaggcgtg gacttcgact actggggcca gggaaccctg      420

gtgaccgtga gctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  179
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  179

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Asn Tyr Gly Phe Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
65                  70                  75                  80  


Asn Thr Asn Tyr Ala Gln Gln Leu Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asp Tyr Gly Glu Thr 
        115                 120                 125             


Gly Val Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  180
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  180
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggt ggcacattca gcagctacgc catcagctgg      180

gttaggcagg ccccaggcca gggcctggag tggatgggcg gcatcatccc catcttcggt      240

acggccaact acgcacagaa gttccagggc agggttacca tcaccgccga cgagagtacc      300

agcactgcct acatggagct gtcaagcctg aggagcgagg acaccgcagt gtactactgc      360

gccagagtca tggtggccgg caccggctac tacttcgact actggggaca ggggaccctg      420

gtgaccgtga gcagcgcaag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  181
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  181

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Met Val Ala Gly Thr 
        115                 120                 125             


Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  182
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  182
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctcgaa agcggcggtg gcctggtgaa gcccggaggc      120

agcctgaggc tgagctgtgc cgccagcggg ttcaccttca gcagctactg gatgagctgg      180

gtgcgccagg cacccggcaa gggcctggag tgggtgagca gcataagcag tagcggcaac      240

tatatgtact acgccgtcag cgtgaagggc aggttcacta tcagccggga cgatagcaag      300

aacaccctgt acctgcagat gaacagcttg aaaacagagg acaccgcagt ttactactgc      360

gccaccgaga cgtacagcta cagcagtatg gacgtgtggg gccagggcac caccgtgacc      420

gttagctctg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  183
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  183

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Gly Asn 
65                  70                  75                  80  


Tyr Met Tyr Tyr Ala Val Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Glu Thr Tyr Ser Tyr Ser 
        115                 120                 125             


Ser Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  184
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  184
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggtgcc      120

agcgtaaagg tgagctgcaa ggccagcggc tacaccttca ccgagaacga gatgcactgg      180

gtaaggcaag cccctggcca aggcctggag tggatgggct ggatcagcgc ctacaacggc      240

gacaccaact acgcccagaa gttccaaggc agggtgacca tgaccaggga caccagcact      300

agcacagtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaaggagg tgaggctgga cgacgatgag atgtggtact tcgacctgtg gggcaggggc      420

accctggtga ccgtgagctc tgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  185
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  185

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Glu Asn Glu Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly 
65                  70                  75                  80  


Asp Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Val Arg Leu Asp Asp 
        115                 120                 125             


Asp Glu Met Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  186
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  186
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctcgag agtggcggag gtctggtgaa gccaggggga      120

agcctgaggc tgagctgcgc ggcaagcggt ttcaccttca gcagctactg gatgagctgg      180

gtgaggcagg cacccggcaa gggcctggag tgggtgtcag ccatcggcac agctggcgac      240

acctactacc ccggcagcgt gaagggcagg ttcaccatca gcagggacga cagcaagaac      300

accctgtacc tgcagatgaa cagcctgaag accgaggaca ccgccgtgta ctactgcgca      360

atcctgcgaa gggacaaggt gtggcccttc gactactggg gccagggcac cctggtgacc      420

gtgagcagcg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  187
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  187

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp 
65                  70                  75                  80  


Thr Tyr Tyr Pro Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Ile Leu Arg Arg Asp Lys Val Trp 
        115                 120                 125             


Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  188
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  188
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggcgctg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagtggc ggcacgttca gcagctatgc cctgagctgg      180

gtgaggcagg cccctggcca aggcctggag tggatgggcg gcatcatccc catcttcggc      240

acggccaact acgcccagaa gttccaggga agggtgacca tcaccgccga cgagtctacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acactgccgt ttattactgc      360

gccagggcgg ctgccgctgg taccgcctgg tacttcgacc tgtggggcag gggcaccctg      420

gtgaccgtga gctccgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  189
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  189

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Leu Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Ala Ala Ala Gly Thr 
        115                 120                 125             


Ala Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  190
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  190
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggttca gctgctggag tccggcggtg gtctggtgca gccgggaggt      120

agcctgcggc tgagctgcgc cgcaagcggc ttctcattca gcacctattg gatgcactgg      180

gtgaggcagg ctcccggaaa gggcctggag tgggtcagcg gcatcagcgg gggtgggatc      240

tacacctact acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaactccctg agggcagagg acacagcggt gtactactgc      360

gccagcatga cctacggcga ctactatggc atggacgtgt ggggccaggg caccaccgtc      420

accgttagca gcgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  191
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  191

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Ser Phe Ser Thr Tyr Trp Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Gly Gly Gly Ile 
65                  70                  75                  80  


Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Met Thr Tyr Gly Asp Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  192
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  192
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggaaccttca gcaactacgc catcagctgg      180

gtgaggcagg ctccgggaca gggcctggag tggatgggag gcatcatccc catcttcggc      240

accgcaaact atgcccagaa gttccaggga agggtgacca tcaccgccga cgagtcaacc      300

agtaccgcct acatggagtt gagcagcctg aggagcgagg acacagccgt gtactactgc      360

gccaaggacc tgggcggctg gttcaacctg ttcgacccct ggggccaggg cacactggtg      420

accgtgtcta gcgcaagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  193
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  193

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Asn Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Leu Gly Gly Trp Phe 
        115                 120                 125             


Asn Leu Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  194
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  194
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggttcag agcggagccg aagtgaagaa gcccggtgcc      120

agcgtgaagg tgagctgcaa ggccagcggc tacaccttcg ccggtcagta catgcactgg      180

gtgaggcagg cccctgggca gggtctggag tggatgggca acatcaaccc cagcggaggt      240

agcaccagct acgcccagag gttccagggc cgagtgacca tgaccaggga cacctccacc      300

agcactgtgt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccaggggag actacagcga gacctactat tactatatgg acgtgtgggg caagggcacc      420

accgtgaccg tgagctctgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  195
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  195

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ala Gly Gln Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Asn Ile Asn Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Thr Ser Tyr Ala Gln Arg Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Asp Tyr Ser Glu Thr 
        115                 120                 125             


Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  196
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  196
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggttca gctcctggag agcggcggtg gtctggtgca gcccggtggc      120

agcctgaggc tgagctgcgc ggcaagcggc ttcaccttca gcagctactg gatgagctgg      180

gtcaggcaag ccccaggaaa gggcctggag tgggtgagca gcatctccag cagcggaggg      240

tacctgtact acgccgacag cgtgaagggc aggttcacca taagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcttg agggccgagg acactgccgt ttactactgc      360

gccagggact ggggccttac ccctgactac tggggtcaag gcaccctggt gaccgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  197
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  197

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Gly Gly 
65                  70                  75                  80  


Tyr Leu Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Trp Gly Leu Thr Pro 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  198
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  198
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgcttgag tccggcggag gcctggtgaa acccggaggt      120

agcctgaggc tgagctgtgc ggccagcggc ttcaccttca gcagctactg gatgagctgg      180

gtcaggcagg cccctggcaa gggcctggag tgggtgagcg ctatcagcgg caccgccatc      240

aacacctact acgccgatag cgtgaagggc aggttcacca ttagcaggga cgacagcaag      300

aacaccctgt acctgcagat gaacagcctg aagaccgagg acacagccgt gtactactgc      360

gccagggtgc ggagggattc ctcaggtggt ggggctttcg acatctgggg ccagggcacg      420

atggtcaccg tgtcaagcgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  199
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  199

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Thr Ala Ile 
65                  70                  75                  80  


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Arg Arg Asp Ser Ser 
        115                 120                 125             


Gly Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  200
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  200
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacacgtttt ccgacttcag catccactgg      180

gtgaggcagg ccccaggcca ggggctggaa tggatgggcg gcatgctgcc catcagccac      240

attgcccact acgctaggaa gttccaggga agggtgacca ttaccgccga cgagagcaca      300

tccaccgcct acatggagct gagcagcctg agaagcgagg acaccgccgt gtactactgc      360

gcaaggggcg gaagctctgg ctggttcgag gtgtggggcc aaggcaccac cgtgaccgtt      420

agctctgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  201
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  201

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Asp Phe Ser Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Met Leu Pro Ile Ser His 
65                  70                  75                  80  


Ile Ala His Tyr Ala Arg Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Ser Ser Gly Trp 
        115                 120                 125             


Phe Glu Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  202
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  202
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctcgag agcggcggtg gccttgtgaa acctggcggg      120

agccttaggc tgagctgtgc cgccagcggc ttcaccttca gcagctactg gatgagctgg      180

gtgaggcaag cgcctggaaa gggcctcgag tgggtcagcg tgatctactc tggtggcagc      240

acctactacg ccgatagcgt gaagggcagg ttcaccatct ccagggacga cagcaagaac      300

accctgtacc tgcagatgaa cagcctcaag accgaagaca ccgcagtata ttactgcgcc      360

aggggccttg gctggtttga cccctggggc cagggcaccc tggtgactgt gagcagcgcc      420

agcaccaagg gccccagcgt gttccctctg gcccccagca gcaagagcac cagcggcgga      480

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg      540

aacagcggcg ctctgaccag cggagtgcac accttccctg ccgtgctgca gagcagcggc      600

ctgtactccc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac      660

atctgcaacg tgaaccacaa gccctccaac accaaggtgg acaagaaggt ggagcctaag      720

agctgcgaca agacccacac ctgccctccc tgccccgccc ccgagctgct gggcggaccc      780

agcgtgttcc tgttccctcc caagcccaag gacaccctga tgatcagccg cacccccgag      840

gtgacctgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt caactggtac      900

gtggacggcg tggaggtgca caacgccaag accaagcctc gggaggagca gtacaactcc      960

acctaccgcg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag     1020

tacaagtgca aggtgagcaa caaggccctg cccgctccca tcgagaagac catcagcaag     1080

gccaagggcc agccccggga gcctcaggtg tacaccctgc cccccagccg cgaagagatg     1140

accaagaacc aggtgagcct gacctgcctg gtgaagggct tctacccctc cgacatcgcc     1200

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg     1260

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagtc ccggtggcag     1320

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1380

aagagcctga gcctgagccc cggatagtaa                                      1410


<210>  203
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  203

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Leu Gly Trp Phe Asp Pro 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly 
465             


<210>  204
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  204
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gttggtgcag agtggggccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagtggc gggagcttca gcggccaggc cgtgaactgg      180

gtgaggcagg ctccgggtca gggcttggag tggatgggtg gattcgtgag cctgttcggc      240

accgccaact acgcgcagaa gttccaaggc cgggtgacca tcaccgccga cgagagcacc      300

agcactgcct acatggagct gagcagcctg aggagcgaag acacggcagt ctactactgc      360

gccagggaca gggaggggct ggggtggtac tttgacctgt ggggcagggg cacccttgta      420

accgtgagtt ccgccagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  205
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  205

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Ser Phe Ser Gly Gln Ala Val Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Phe Val Ser Leu Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Glu Gly Leu Gly 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  206
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  206
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggggcag aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc ggtaccttct ccacctacgc tatcagctgg      180

gttaggcagg ccccaggcca gggcctggag tggatgggcg gcatcattcc cagcttcaac      240

gcccccagct acgcccaaaa gttccaggga agggtgacca tcactgcaga caagagcacc      300

tccacggcgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggtgg tgcccgctgc catcgtgggc tggtatttcg acctgtgggg caggggaacc      420

ttggtgaccg tgagctctgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  207
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  207

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Thr Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ser Phe Asn 
65                  70                  75                  80  


Ala Pro Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Pro Ala Ala Ile 
        115                 120                 125             


Val Gly Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  208
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  208
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagtggc ggcatcctga acagctacgc catcacctgg      180

gtgaggcagg cgccaggtca aggcctggag tggatgggca ggatcatccc catcctgggc      240

atcgccaact acgcccagaa gttccagggc agggtgacca tcactgccga cgagagcacc      300

tccaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gtggagaacg agtcaggccc cctgttcgac tactggggcc agggaaccct ggtgaccgtg      420

agctctgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  209
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  209

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Ile Leu Asn Ser Tyr Ala Ile Thr Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Ile Pro Ile Leu Gly 
65                  70                  75                  80  


Ile Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Val Glu Asn Glu Ser Gly Pro Leu 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  210
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  210
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacacgttca ctagctacgg cataagctgg      180

gtgaggcagg ccccaggaca gggcctggag tggatgggcg gcatcatccc catcttcggc      240

accgccaact acgcccagaa gttccagggt agggtgacca ttaccgcaga cgagagcacc      300

tccaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggtta tggccaggag ggacgggtac aacttcaagg gcggctggta cttcgacctg      420

tggggcaggg gcaccttggt gaccgtgagc tctgccagca ccaagggccc cagcgtgttc      480

cctctggccc ccagcagcaa gagcaccagc ggcggaaccg ccgccctggg ctgcctggtg      540

aaggactact tccccgagcc cgtgaccgtg tcctggaaca gcggcgctct gaccagcgga      600

gtgcacacct tccctgccgt gctgcagagc agcggcctgt actccctgag cagcgtggtg      660

accgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      720

tccaacacca aggtggacaa gaaggtggag cctaagagct gcgacaagac ccacacctgc      780

cctccctgcc ccgcccccga gctgctgggc ggacccagcg tgttcctgtt ccctcccaag      840

cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt ggtggacgtg      900

agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac      960

gccaagacca agcctcggga ggagcagtac aactccacct accgcgtggt gagcgtgctg     1020

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gagcaacaag     1080

gccctgcccg ctcccatcga gaagaccatc agcaaggcca agggccagcc ccgggagcct     1140

caggtgtaca ccctgccccc cagccgcgaa gagatgacca agaaccaggt gagcctgacc     1200

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagag caacggccag     1260

cctgagaaca actacaagac cacccctccc gtgctggaca gcgacggcag cttcttcctg     1320

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1380

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gagccccgga     1440

tagtaa                                                                1446


<210>  211
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  211

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Met Ala Arg Arg Asp 
        115                 120                 125             


Gly Tyr Asn Phe Lys Gly Gly Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


<210>  212
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  212
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggcgcag aggtgaagaa gcccggaagc      120

agcgtgaagg tgagctgcaa ggccagcggt ttcagcttca gcacctacgg cgtggcctgg      180

gtgaggcagg caccaggaca ggggttggaa tggatgggcg gcttcgtgcc catcatcggc      240

agcgccaact acgcccagaa gttccaaggc agggtgacca tcaccgccga cgagagcact      300

agtaccgcct acatggagct gagcagcctg aggagcgagg ataccgccgt gtactactgc      360

gccagggact acggaggcaa cctggattac tggggccagg gcaccctggt gaccgtgagc      420

tccgcaagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  213
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  213

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Phe Ser Phe Ser Thr Tyr Gly Val Ala Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Phe Val Pro Ile Ile Gly 
65                  70                  75                  80  


Ser Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Gly Asn Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  214
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  214
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggtgccg aggtgaagaa gcccggcagc      120

agtgtgaagg tgagttgcaa ggccagcggc ggtagcttca gcagttgggc catctcatgg      180

gtgaggcagg cccctggcca aggactggag tggatgggcg gcatcatccc cctgttcggc      240

acggtgaact acgcccagaa gttccagggc agggtgacca tcaccgcaga cgagtccacc      300

agcaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggacc tccccgatat ggtgagctgg gggcaaggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  215
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  215

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Ser Phe Ser Ser Trp Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Leu Phe Gly 
65                  70                  75                  80  


Thr Val Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Pro Asp Met Val 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  216
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  216
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgcttgag tccggcggag gcctggtgaa acccggaggt      120

agcctgaggc tgagctgtgc ggccagcggc ttcaccttca gcagctactg gatgagctgg      180

gtcaggcagg cccctggcaa gggcctggag tgggtgagcg ctatcagcgg caccgccatc      240

aacacctact acgccgatag cgtgaagggc aggttcacca ttagcaggga cgacagcaag      300

aacaccctgt acctgcagat gaacagcctg aagaccgagg acacagccgt gtactactgc      360

gccagggtgc ggagggattc ctcaggtggt ggggctttcg acatctgggg ccagggcacg      420

atggtcaccg tgtcaagcgc cagcaccaag ggccccagcg tgttccctct ggcccccagc      480

agcaagagca ccagcggcgg aaccgccgcc ctgggctgcc tggtgaagga ctacttcccc      540

gagcccgtga ccgtgtcctg gaacagcggc gctctgacca gcggagtgca caccttccct      600

gccgtgctgc agagcagcgg cctgtactcc ctgagcagcg tggtgaccgt gcccagcagc      660

agcctgggca cccagaccta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagcctaa gagctgcgac aagacccaca cctgccctcc ctgccccgcc      780

cccgagctgc tgggcggacc cagcgtgttc ctgttccctc ccaagcccaa ggacaccctg      840

atgatcagcc gcacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct      960

cgggaggagc agtacaactc cacctaccgc gtggtgagcg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga gtacaagtgc aaggtgagca acaaggccct gcccgctccc     1080

atcgagaaga ccatcagcaa ggccaagggc cagccccggg agcctcaggt gtacaccctg     1140

ccccccagcc gcgaagagat gaccaagaac caggtgagcc tgacctgcct ggtgaagggc     1200

ttctacccct ccgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1260

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt cccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1380

ctgcacaacc actacaccca gaagagcctg agcctgagcc ccggatagta a              1431


<210>  217
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  217

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Thr Ala Ile 
65                  70                  75                  80  


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Arg Arg Asp Ser Ser 
        115                 120                 125             


Gly Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  218
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  218
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gttgctggag agcggaggcg gtctggtgca gccaggcggc      120

agccttaggc tgagctgcgc cgctagtggc ttcaccttca gcgactacta catgaactgg      180

gtgaggcagg cacccggtaa gggcctggag tgggtaagca ctatcagcgg cttcggcgag      240

agcaccttct acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcaaat gaacagcctc agggccgagg acaccgccgt gtactactgc      360

gccaggctgg gtgcggcacg cgctttcgat atctggggcc agggaaccac cgtgaccgtg      420

agcagcgcca gcaccaaggg ccccagcgtg ttccctctgg cccccagcag caagagcacc      480

agcggcggaa ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      540

gtgtcctgga acagcggcgc tctgaccagc ggagtgcaca ccttccctgc cgtgctgcag      600

agcagcggcc tgtactccct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      660

cagacctaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagcctaaga gctgcgacaa gacccacacc tgccctccct gccccgcccc cgagctgctg      780

ggcggaccca gcgtgttcct gttccctccc aagcccaagg acaccctgat gatcagccgc      840

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      900

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagcctcg ggaggagcag      960

tacaactcca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac     1020

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgctcccat cgagaagacc     1080

atcagcaagg ccaagggcca gccccgggag cctcaggtgt acaccctgcc ccccagccgc     1140

gaagagatga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctacccctcc     1200

gacatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccacccct     1260

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagtcc     1320

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1380

tacacccaga agagcctgag cctgagcccc ggatagtaa                            1419


<210>  219
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  219

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Phe Gly Glu 
65                  70                  75                  80  


Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Ala Arg Ala 
        115                 120                 125             


Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210>  220
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  220
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca gctcctggag agtggcggtg gccttgtgca gcccggtggc      120

agcctgcgac tgagctgcgc cgcaagcggc ttcaccttca gcaattacgc aatggcctgg      180

gtgaggcagg ccccaggcaa gggcctggag tgggtcagct ggatcagcgg cagcggtagc      240

tatatctact acgccgacag cgtgaagggc aggttcacca tcagcaggga caacagtaag      300

aacaccctgt acctgcagat gaacagcctg agggcagaag acaccgccgt gtactactgc      360

gccaggaggg gcagcagctg gtcaaacttc gactactggg gtcagggcac cctggtgacc      420

gtgagcagcg ccagcaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      480

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      540

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      600

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      660

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      780

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      840

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag      960

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1080

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1140

cgcgaagaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1200

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1260

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1320

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1380

cactacaccc agaagagcct gagcctgagc cccggatagt aa                        1422


<210>  221
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  221

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Asn Tyr Ala Met Ala Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ser Trp Ile Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Ser Trp Ser 
        115                 120                 125             


Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  222
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  222
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggcgctg aggtgaagaa gcccggagcc      120

agcgtgaagg tgagctgcaa ggccagcggc tacaccttta gcacctacga tatcaactgg      180

gtgaggcagg ctcctggtca gggcctggag tgggtgggca tcatcagccc cagcggaggc      240

tggaccacct atgcccagaa gttccaggga agggtgacca tgacccgcga caccagcacg      300

agtaccgtgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggtca actacgacat cctgaccggg cagggcagag gctactactt cgactactgg      420

ggccagggca cactggtgac cgtgagctct gccagcacca agggccccag cgtgttccct      480

ctggccccca gcagcaagag caccagcggc ggaaccgccg ccctgggctg cctggtgaag      540

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gcgctctgac cagcggagtg      600

cacaccttcc ctgccgtgct gcagagcagc ggcctgtact ccctgagcag cgtggtgacc      660

gtgcccagca gcagcctggg cacccagacc tacatctgca acgtgaacca caagccctcc      720

aacaccaagg tggacaagaa ggtggagcct aagagctgcg acaagaccca cacctgccct      780

ccctgccccg cccccgagct gctgggcgga cccagcgtgt tcctgttccc tcccaagccc      840

aaggacaccc tgatgatcag ccgcaccccc gaggtgacct gcgtggtggt ggacgtgagc      900

cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc      960

aagaccaagc ctcgggagga gcagtacaac tccacctacc gcgtggtgag cgtgctgacc     1020

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgag caacaaggcc     1080

ctgcccgctc ccatcgagaa gaccatcagc aaggccaagg gccagccccg ggagcctcag     1140

gtgtacaccc tgccccccag ccgcgaagag atgaccaaga accaggtgag cctgacctgc     1200

ctggtgaagg gcttctaccc ctccgacatc gccgtggagt gggagagcaa cggccagcct     1260

gagaacaact acaagaccac ccctcccgtg ctggacagcg acggcagctt cttcctgtac     1320

agcaagctga ccgtggacaa gtcccggtgg cagcagggca acgtgttcag ctgcagcgtg     1380

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgag ccccggatag     1440

taa                                                                   1443


<210>  223
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  223

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Ser Thr Tyr Asp Ile Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Val Gly Ile Ile Ser Pro Ser Gly Gly 
65                  70                  75                  80  


Trp Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asn Tyr Asp Ile Leu 
        115                 120                 125             


Thr Gly Gln Gly Arg Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 


<210>  224
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  224
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tccggagcgg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacatcttca caaggtacta cgtgaactgg      180

gtgaggcagg cgccaggaca gggcctggag tggatgggcg gcatcatccc catgttcgga      240

accagcaact acgcccagaa gttccagggc agggtgacca tcaccgcaga cgagagcacc      300

tccaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gcgaggagca gcggatatga cagcttcaag atcgactact ggggccaggg gaccctggtg      420

accgtgagct ctgcaagcac caagggcccc agcgtgttcc ctctggcccc cagcagcaag      480

agcaccagcg gcggaaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      540

gtgaccgtgt cctggaacag cggcgctctg accagcggag tgcacacctt ccctgccgtg      600

ctgcagagca gcggcctgta ctccctgagc agcgtggtga ccgtgcccag cagcagcctg      660

ggcacccaga cctacatctg caacgtgaac cacaagccct ccaacaccaa ggtggacaag      720

aaggtggagc ctaagagctg cgacaagacc cacacctgcc ctccctgccc cgcccccgag      780

ctgctgggcg gacccagcgt gttcctgttc cctcccaagc ccaaggacac cctgatgatc      840

agccgcaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga ccccgaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgggag      960

gagcagtaca actccaccta ccgcgtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtg agcaacaagg ccctgcccgc tcccatcgag     1080

aagaccatca gcaaggccaa gggccagccc cgggagcctc aggtgtacac cctgcccccc     1140

agccgcgaag agatgaccaa gaaccaggtg agcctgacct gcctggtgaa gggcttctac     1200

ccctccgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1260

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1380

aaccactaca cccagaagag cctgagcctg agccccggat agtaa                     1425


<210>  225
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  225

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Ile Phe Thr Arg Tyr Tyr Val Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Met Phe Gly 
65                  70                  75                  80  


Thr Ser Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ser Gly Tyr Asp Ser 
        115                 120                 125             


Phe Lys Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470             


<210>  226
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  226
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggttcag agcggggcag aggtgaagaa gcccggtgcc      120

agcgtgaaag tgagctgcaa ggccagcggc tacaccttca ccagctacta catgcactgg      180

gtgaggcagg cacccggaca gggcctggag tggatgggct ggatgaaccc caacagcggc      240

aacaccggct acgcccagaa gtttcagggc agggtgacca tgaccaggga caccagcacc      300

tccaccgttt acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggaga ccagcttcga ttactactac ggcatggacg tgtggggcca gggcaccacc      420

gtgaccgtga gctctgccag caccaagggc cccagcgtgt tccctctggc ccccagcagc      480

aagagcacca gcggcggaac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgtcctggaa cagcggcgct ctgaccagcg gagtgcacac cttccctgcc      600

gtgctgcaga gcagcggcct gtactccctg agcagcgtgg tgaccgtgcc cagcagcagc      660

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc cctccaacac caaggtggac      720

aagaaggtgg agcctaagag ctgcgacaag acccacacct gccctccctg ccccgccccc      780

gagctgctgg gcggacccag cgtgttcctg ttccctccca agcccaagga caccctgatg      840

atcagccgca cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccccgag      900

gtgaagttca actggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcctcgg      960

gaggagcagt acaactccac ctaccgcgtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtgagcaaca aggccctgcc cgctcccatc     1080

gagaagacca tcagcaaggc caagggccag ccccgggagc ctcaggtgta caccctgccc     1140

cccagccgcg aagagatgac caagaaccag gtgagcctga cctgcctggt gaagggcttc     1200

tacccctccg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1260

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctgagc ctgagccccg gatagtaa                  1428


<210>  227
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  227

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Met Asn Pro Asn Ser Gly 
65                  70                  75                  80  


Asn Thr Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Thr Ser Phe Asp Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  228
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  228
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtccag agcggggcag aggtgaagaa gcccggcagc      120

agtgtgaagg tgagctgcaa ggccagcggc tacacgttca ccaactatgc catcatctgg      180

gtaaggcagg cacccggcca gggcctggag tggatgggcg gcatcatccc cgtgttcggc      240

accgccgact acactcagac cttccagggt agagtgacca tcaccgcaga cgagagcacc      300

agcaccgctt acatggagct gagtagcctt cgcagcgagg acacagccgt gtactactgc      360

gcccgagtat ccacgaacta ctacgacagc tcaggctatt acgccttcga ctactggggg      420

caggggaccc tggtgaccgt gagcagcgcc agcaccaagg gccccagcgt gttccctctg      480

gcccccagca gcaagagcac cagcggcgga accgccgccc tgggctgcct ggtgaaggac      540

tacttccccg agcccgtgac cgtgtcctgg aacagcggcg ctctgaccag cggagtgcac      600

accttccctg ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgaccgtg      660

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gccctccaac      720

accaaggtgg acaagaaggt ggagcctaag agctgcgaca agacccacac ctgccctccc      780

tgccccgccc ccgagctgct gggcggaccc agcgtgttcc tgttccctcc caagcccaag      840

gacaccctga tgatcagccg cacccccgag gtgacctgcg tggtggtgga cgtgagccac      900

gaggaccccg aggtgaagtt caactggtac gtggacggcg tggaggtgca caacgccaag      960

accaagcctc gggaggagca gtacaactcc acctaccgcg tggtgagcgt gctgaccgtg     1020

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtgagcaa caaggccctg     1080

cccgctccca tcgagaagac catcagcaag gccaagggcc agccccggga gcctcaggtg     1140

tacaccctgc cccccagccg cgaagagatg accaagaacc aggtgagcct gacctgcctg     1200

gtgaagggct tctacccctc cgacatcgcc gtggagtggg agagcaacgg ccagcctgag     1260

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctgtacagc     1320

aagctgaccg tggacaagtc ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1380

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc cggatagtaa     1440


<210>  229
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  229

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asn Tyr Ala Ile Ile Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Val Phe Gly 
65                  70                  75                  80  


Thr Ala Asp Tyr Thr Gln Thr Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Ser Thr Asn Tyr Tyr 
        115                 120                 125             


Asp Ser Ser Gly Tyr Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  230
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  230
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gcgaggtgca actgctggag tctggtggcg gcctggtgca gcccggagga      120

agccttaggt tgagctgcgc cgcaagcggc ttcaccttca gcagctacgc catgcactgg      180

gtgaggcagg ccccagggaa gggcctggag tgggttgccg ttatgagcta cgacggcagg      240

cacgagtact atgccgacag cgtgaagggc aggttcacca tcagcaggga caacagcaag      300

aacaccctgt acctgcagat gaacagcctg agggccgagg ataccgcagt gtactactgc      360

gccagcaccg actacgacat cggcggatac agcctccccc tggactactg gggacagggc      420

accctggtga ccgtgagcag cgccagcacc aagggcccca gcgtgttccc tctggccccc      480

agcagcaaga gcaccagcgg cggaaccgcc gccctgggct gcctggtgaa ggactacttc      540

cccgagcccg tgaccgtgtc ctggaacagc ggcgctctga ccagcggagt gcacaccttc      600

cctgccgtgc tgcagagcag cggcctgtac tccctgagca gcgtggtgac cgtgcccagc      660

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc taagagctgc gacaagaccc acacctgccc tccctgcccc      780

gcccccgagc tgctgggcgg acccagcgtg ttcctgttcc ctcccaagcc caaggacacc      840

ctgatgatca gccgcacccc cgaggtgacc tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag      960

cctcgggagg agcagtacaa ctccacctac cgcgtggtga gcgtgctgac cgtgctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtga gcaacaaggc cctgcccgct     1080

cccatcgaga agaccatcag caaggccaag ggccagcccc gggagcctca ggtgtacacc     1140

ctgcccccca gccgcgaaga gatgaccaag aaccaggtga gcctgacctg cctggtgaag     1200

ggcttctacc cctccgacat cgccgtggag tgggagagca acggccagcc tgagaacaac     1260

tacaagacca cccctcccgt gctggacagc gacggcagct tcttcctgta cagcaagctg     1320

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag     1380

gccctgcaca accactacac ccagaagagc ctgagcctga gccccggata gtaa           1434


<210>  231
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  231

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Glu Val Gln Leu Leu Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Met Ser Tyr Asp Gly Arg 
65                  70                  75                  80  


His Glu Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Thr Asp Tyr Asp Ile Gly 
        115                 120                 125             


Gly Tyr Ser Leu Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475     


<210>  232
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  232
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tccggcgcag aagtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacactttca cggactacta catccactgg      180

gtgaggcagg cacccggtca aggtctggaa tggatgggcg gcatcatccc catctacggc      240

accgcaaact acgcccagaa gttccaaggc agggtgacca tcaccgctga cgagagcacc      300

agtaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt ctactactgc      360

gccaggacta actggggtat ggacgtgtgg ggccagggga ccaccgtgac tgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  233
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  233

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Tyr Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Asn Trp Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  234
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  234
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctcgtgcag agcggtgccc aggtgaagaa gcccggtgcc      120

agcgtgaagg tgagttgcaa ggcctcaggc ggcactttca gcagctacac catcagctgg      180

gtgaggcagg ccccaggtca gggccttgag tggatgggcg tgatctaccc cagcggcgac      240

atcaccgttt acgcccagga gttccagggc agggtgacca tgaccaggga cacctctacc      300

agcaccgtgt atatggagct gagcagtctg aggagcgagg acaccgccgt gtactactgc      360

gccagggcgt gggccagata cttcgactac tggggtcaag gcaccctggt gactgtgagc      420

tctgccagca ccaagggccc cagcgtgttc cctctggccc ccagcagcaa gagcaccagc      480

ggcggaaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      540

tcctggaaca gcggcgctct gaccagcgga gtgcacacct tccctgccgt gctgcagagc      600

agcggcctgt actccctgag cagcgtggtg accgtgccca gcagcagcct gggcacccag      660

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

cctaagagct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc      780

ggacccagcg tgttcctgtt ccctcccaag cccaaggaca ccctgatgat cagccgcacc      840

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg accccgaggt gaagttcaac      900

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcggga ggagcagtac      960

aactccacct accgcgtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag gccctgcccg ctcccatcga gaagaccatc     1080

agcaaggcca agggccagcc ccgggagcct caggtgtaca ccctgccccc cagccgcgaa     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccctccgac     1200

atcgccgtgg agtgggagag caacggccag cctgagaaca actacaagac cacccctccc     1260

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtcccgg     1320

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgagcct gagccccgga tagtaa                               1416


<210>  235
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  235

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Gln Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Thr Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Val Ile Tyr Pro Ser Gly Asp 
65                  70                  75                  80  


Ile Thr Val Tyr Ala Gln Glu Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Trp Ala Arg Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly 
465                 470 


<210>  236
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  236
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag agcggagccg aggtgaagaa acctggcgca      120

agcgttaagg tgagctgcaa ggcctctggc aacaccttca ccgcctacta catgcactgg      180

gtgaggcagg caccaggcca gggcctggaa tggatgggca tcatcaaccc cagtgggggc      240

tcaaccagct acgcccagaa gttccaggga agggttacca tgaccaggga tacctccacc      300

agcaccgtgt atatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gcaaggggcg tgggagccac caactactgg ggacagggca ccctggtgac cgtgagctct      420

gccagcacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgaagag     1140

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggatag taa                                  1413


<210>  237
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  237

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Asn Thr Phe Thr Ala Tyr Tyr Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly 
65                  70                  75                  80  


Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg 
                85                  90                  95      


Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Val Gly Ala Thr Asn 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  238
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  238
atggacccca agggcagcct gagctggaga atcctgctgt tcctgagcct ggccttcgag       60

ctgagctacg gccaggtgca gctggtgcag tcaggtgccg aggtgaagaa gcccggcagc      120

agcgtgaagg tgagctgcaa ggccagcggc tacaggttca ccgactacta tatccactgg      180

gtgaggcagg ctcccggaca gggcctggag tggatgggca tcatccagcc caccggcgga      240

gggaccacct acgctcagaa gttccagggc agggtgacca tcactgccga cgagagcacc      300

agtaccgcct acatggagct gagcagcctg aggagcgagg acaccgccgt gtactactgc      360

gccagggtgg gcgccactgt gacaaagaat tactattact actacggcat ggacgtgtgg      420

ggccaaggca ccaccgttac cgtgagctct gccagcacca agggccccag cgtgttccct      480

ctggccccca gcagcaagag caccagcggc ggaaccgccg ccctgggctg cctggtgaag      540

gactacttcc ccgagcccgt gaccgtgtcc tggaacagcg gcgctctgac cagcggagtg      600

cacaccttcc ctgccgtgct gcagagcagc ggcctgtact ccctgagcag cgtggtgacc      660

gtgcccagca gcagcctggg cacccagacc tacatctgca acgtgaacca caagccctcc      720

aacaccaagg tggacaagaa ggtggagcct aagagctgcg acaagaccca cacctgccct      780

ccctgccccg cccccgagct gctgggcgga cccagcgtgt tcctgttccc tcccaagccc      840

aaggacaccc tgatgatcag ccgcaccccc gaggtgacct gcgtggtggt ggacgtgagc      900

cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc      960

aagaccaagc ctcgggagga gcagtacaac tccacctacc gcgtggtgag cgtgctgacc     1020

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgag caacaaggcc     1080

ctgcccgctc ccatcgagaa gaccatcagc aaggccaagg gccagccccg ggagcctcag     1140

gtgtacaccc tgccccccag ccgcgaagag atgaccaaga accaggtgag cctgacctgc     1200

ctggtgaagg gcttctaccc ctccgacatc gccgtggagt gggagagcaa cggccagcct     1260

gagaacaact acaagaccac ccctcccgtg ctggacagcg acggcagctt cttcctgtac     1320

agcaagctga ccgtggacaa gtcccggtgg cagcagggca acgtgttcag ctgcagcgtg     1380

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgag ccccggatag     1440

taa                                                                   1443


<210>  239
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 heavy chain

<400>  239

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Tyr Arg Phe Thr Asp Tyr Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Gln Pro Thr Gly Gly 
65                  70                  75                  80  


Gly Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Ala Thr Val Thr 
        115                 120                 125             


Lys Asn Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
    130                 135                 140                 


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
145                 150                 155                 160 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
                165                 170                 175     


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
            180                 185                 190         


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
        195                 200                 205             


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
225                 230                 235                 240 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 


<210>  240
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  240
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccaaag ccccctgagc ctgcccgtga ctcccggcga gcccgcctca      120

atcagctgca ggagcagcca aagtttgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agcctggaca gagcccacaa ctgttgatct acgccgccag cagccttcaa      240

agcggcgtgc ccgacaggtt cagcggcagt ggaagtggca ccgacttcac cctgaagatc      300

agcagggtgg aggccgagga cgtgggcgtc tactactgta tgcaggccct gcaaacccca      360

cccaccttcg gccagggaac caaggtggaa atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  241
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  241

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  242
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  242
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gagggccacc      120

atcaactgca agagcagcca gagcgtgctt tacagcagca acaacaagaa ctacctggcg      180

tggtatcagc agaagcccgg tcagccccct aagctcctga tctactgggc cagcaccagg      240

gagagcggcg tgcctgacag attcagcggc agcgggagcg gcaccgattt caccctgacc      300

attagcagcc ttcaggccga ggacgtggct gtgtactact gccagcagta ctacaccagc      360

ccgaccttcg gccaaggcac caagttggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  243
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  243

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Thr Ser Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  244
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  244
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccctctgagc ctgcccgtga cccccggtga gcccgccagc      120

atcagctgca ggagctcaca gtcactgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agccgggtca gtctccccag ctgttgatct acttgggcag caacagggcc      240

agcggcgtgc ccgacaggtt cagcggcagc ggtagcggca ccgacttcac cctgaagatt      300

agcagggtgg aggccgagga cgtgggcgtt tactactgta tgcagagcat ccagatccca      360

cccaccttcg gccctggaac caaggtggac atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  245
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  245

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ser Ile Gln Ile Pro Pro Thr Phe Gly Pro Gly Thr Lys 
        115                 120                 125             


Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  246
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  246
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag tcccgccaca ctgagcgtga gccccggaga gcgagccacc      120

ctgagctgca gggccagcca gagtgtgagc agcagctacc tggcctggta tcaacagaag      180

cccggtcaag cccccaggct gctgatctac ggcgccagca cacgcgccac cggcatcccc      240

gctaggttca gcggcagtgg cagcggcacc gagttcaccc ttaccattag cagcttgcag      300

agtgaggact tcgccgtgta ctactgccag cagagctaca gcattccctt caccttcggc      360

cagggaacca agctggagat caagaggacc gtggccgccc ccagcgtgtt catcttccct      420

cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   708


<210>  247
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  247

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Tyr Ser Ile Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  248
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  248
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggccagcca gggcatcggc aacgacctgg cctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagtagct tgcagagcgg cgtgcccagc      240

aggttcagtg gcagcggcag tggtaccgac ttcaccctca ccattagcag cctgcagccc      300

gaggacttcg ccacctacta ctgtcagcag agctacagca ccccctacac cttcggacag      360

ggcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  249
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  249

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Gly Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  250
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  250
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagt ctgtccgcca gcgtgggcga cagggttacc      120

atcacctgcc gagccagcca gagcatcagc aactggcttg cctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacagc gccagcagcc tgcagaacgg cgtgcctagc      240

aggttcagcg ggagcggcag cggcaccgac ttcaccctga ccattagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccagcaa agctacagca ccccacccac tttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  251
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  251

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Gln Asn Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  252
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  252
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag tccactgagc ttgcccgtga cgcccggaga gcccgcctca      120

atcagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga aacccggaca gagcccccag ctgctgatct acggcgccag cacactgcag      240

cctggcgtgc ccgacaggtt cagcggcagc ggctccggca ccgacttcac cctgaagata      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcaaggcac ccagtggccc      360

accttcggcc agggcactaa gctggagatc aagaggaccg tggccgcccc cagcgtgttc      420

atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg      480

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      540

ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc      600

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      660

acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaa         717


<210>  253
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  253

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ala Ser Thr Leu Gln 
65                  70                  75                  80  


Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Thr Gln Trp Pro Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  254
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  254
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag cccactgagc ctgcccgtga cccccggaga gccggccagc      120

atcagctgca ggagcagtca gagcttgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agcctggcca aagcccccag ttgctgatct acgccgccag caccttgcag      240

agcggcgtgc ccgacaggtt ctctggcagc gggagcggca ccgacttcac cctgaaaatc      300

agcagggtcg aggccgagga cgtgggcgtg tactactgta tgcagggcac ccattggccc      360

ctgaccttcg gccaaggcac taaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  255
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  255

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Thr His Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  256
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  256
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacg      120

atcacctgcc aggccagcca ggacatcagg aactacctga actggtatca acagaagccc      180

ggcaaggccc ccaagttgct gatctacaaa gccagcagcc tggagagcgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccttga ccatcagcag tctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca ccccacccac cttcggaggc      360

ggaactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  257
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  257

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  258
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  258
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag tccactgagt ctgcccgtga cccccggtga gccggccagc      120

atcagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agccaggcca gtctccccag ctgttgattt acgccgccag taccctgcaa      240

agcggcgtgc ccgacaggtt cagcggcagc gggagcggca ccgacttcac cctgaagatc      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcagggcac ccactggccc      360

accaccttcg gccaaggcac aaggctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  259
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  259

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Thr His Trp Pro Thr Thr Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  260
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  260
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc aggccagcga ggacatcgcc aacaacctga actggtatca gcagaagccc      180

ggcaaggccc ccaaacttct gatctacgcc gccagcagcc tgcagagcgg cgtgcccagt      240

aggttcagcg gcagcggaag tggcaccgac ttcaccctca ccattagcag tctccagccc      300

gaggacttcg ccacatacta ctgccagcaa ggctacaaca tccccttcac cttcggccag      360

ggcaccaagt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  261
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  261

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp 
        35                  40                  45              


Ile Ala Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 
            100                 105                 110         


Asn Ile Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  262
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  262
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctcagtgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagtgagcca gggcataagc aactacctga actggtatca gcagaagccc      180

ggcaaggccc ccaagttgct gatctacggc gccagcactc tgcaaagcgg cgtgccctct      240

aggttcagcg gcagcggtag cggcaccgac ttcaccctca ccatctcaag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca ccccctggac cttcggtccc      360

ggtaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  263
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  263

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Val Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Trp Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  264
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  264
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag cccactgagt ctgcctgtga cgccgggtga gcccgccagc      120

atcagctgca ggagctcaca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacttgcaga agcctggcca aagcccccag ctgctgatct atctggctag caacagggcc      240

agcggcgtgc ccgacaggtt cagcggcagc gggagcggca ccgacttcac cctgaagatc      300

tcaagggtgg aggccgagga cgtgggcgtg tactactgta tgcaagccct gcagaccccc      360

gtgaccttcg gccagtctac caggctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  265
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  265

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Val Thr Phe Gly Gln Ser Thr Arg 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  266
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  266
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag tcccctgagc ctgcccgtga cccccggtga acccgcctcc      120

atcagctgca ggagctcaca aagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agcccggtca aagcccccag ctgctgatct acgacgccag caacctggag      240

accggcgtgc ccgacaggtt cagcggaagc ggcagcggga ccgacttcac cctgaagatt      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcaaggcgc ccactggccc      360

cctactttcg gccagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  267
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  267

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Ala His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  268
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  268
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc aggccagcca gggtatcagc aactacctga attggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatttacgcc gcctcaaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcgggag cggcaccgac tttaccctga cgattagcag tttgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca ctcctcccac cttcggccag      360

ggcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  269
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  269

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  270
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  270
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag ccccgctact ctgagcgtgt cacccggcga gagggccacc      120

ttgagctgca gggccagcca gagcgtgagc agcaacttcg cctggtatca gcagaagccc      180

ggtcaagccc ccaggttgct gatctacggc gccagcacca gggctaccgg catccccgcc      240

aggttcagcg gcagcggaag cggcaccgag ttcaccctga ccatcagtag cctgcagagc      300

gaggactttg ccgtgtacta ctgccagcag tactacagca ccccctacac cttcggccag      360

ggaaccaaag tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  271
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  271

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Asn Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  272
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  272
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctct ctgagcgcca gcgtgggcga cagggtgacg      120

atcacctgcc gagccagcca aagcatcagc acctggcttg cctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacggc gcctctagcc tgcagagcgg tgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcacactga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tcttacaaca gcccctacac gtttggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  273
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  273

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asn Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  274
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  274
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagcca gagcatcagc agctacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaaactcct gatctacgcc gcctcctctc tgcaaagcgg cgtgcccagc      240

aggttcagcg ggagcggcag cggcaccgac tttaccctta ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccttgac cttcggagga      360

ggtactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  275
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  275

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  276
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  276
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagt ctcagcgcca gcgtgggcga cagggttacc      120

atcacctgcc gagccagcca ggacatcggc agctggcttg cctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagcagcc tgcagagcgg cgtgcccagt      240

aggttcagcg gtagcggcag cggcaccgac ttcaccctga ccattagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccagcaa agctacagca ccccacccac tttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  277
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  277

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  278
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  278
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagtagc ctgagcgcca gcgtgggcga cagggtgaca      120

atcacctgta gggcgagcca gagcataagc agctggctgg cctggtatca acagaagccc      180

ggcaaagccc ccaagctgct gatctacgac gccagcaacc tgaagaccgg cgtgcccagc      240

aggttcagcg gctccggcag cggcaccgac ttcaccttga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag acctacgcca tccccctgac cttcggtggc      360

ggcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  279
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  279

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Lys Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr 
            100                 105                 110         


Ala Ile Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  280
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  280
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagtc tcctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

attacctgta gggcctcaca gggcattagc agctggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgct tatctacgag gccagtcacc tggagaccgg cgtgcccagc      240

aggttcagcg gcagcggctc tggaaccgac ttcaccttga ccatcagctc cttgcagccc      300

gaggacttcg ccacctacta ctgcctgcaa gattacaact accccctgac cttcggcgga      360

gggactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  281
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  281

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Glu Ala Ser His Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  282
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  282
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacctgtc gagccagcga gagcatcggc aggtatctga attggtatca gcagaagccc      180

ggcaaggccc caaagctgct catctacggc accagcaacc tggagagcgg cgtgcctagc      240

aggtttagcg gcagcggaag cggaaccgac ttcaccctga ctatctccag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca ctcccccaac tttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  283
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  283

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Ile Gly Arg Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Thr Ser Asn Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  284
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  284
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagt ctcagcgcca gcgtgggcga cagggtaacc      120

atcacctgcc aggcgagcca ggacatcggc agctacctga actggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gcgagctcac tgcagagcgg cgtccccagt      240

aggttcagtg gaagcggcag cggcacagac ttcaccctga ccatctccag cctgcagccc      300

gaggacttcg ccacctacta ctgtctccag agctacagca cccccttcac cttcggtggc      360

ggcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  285
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  285

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  286
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  286
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgagc ctgcccgtga cccctggcga gcccgccagc      120

atcagctgca ggagcagcca aagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga aacccggcca gtcaccgcaa ctgctgatct acctcgctag caacagggcc      240

agcggcgtgc ccgacaggtt ctctggcagc gggagcggca ctgacttcac cctgaagatt      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcaagcctt gcagactccc      360

ccaacattcg gccctggaac caaggtggac atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  287
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  287

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Pro Thr Phe Gly Pro Gly Thr Lys 
        115                 120                 125             


Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  288
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  288
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga cagggttacc      120

atcacgtgca gggccagcca gggcatcagg agcaacctgg actggtatca acagaagccc      180

ggcaaggccc ccaagctgct tatcagcatc gtgtctaacc tgggtagcgg cgtgcccagc      240

aggtttagcg gcagcggctc cggaaccgac ttcaccctga ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgcttgcag cacaacagca atccacccac attcggtggc      360

ggcacaaaag tggaaatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  289
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  289

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Ser Asn Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Ser Ile Val Ser Asn Leu Gly Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
            100                 105                 110         


Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  290
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  290
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgacagc ctggctgtga gcctgggcga gagggccacc      120

atcaactgca agagcagcca gagcgtgttc tacagcagca tcaacaagaa ctctctggcc      180

tggtatcagc agaagcccgg tcagccccca aagctcctga tctactgggc cagcaccagg      240

gagagcggcg tgcccgatag gttcagtggc tcaggcagcg gaaccgactt caccctgaca      300

atcagctctc tgcaggcaga ggacgtggcc gtgtactact gccagcagta ttacagcacc      360

cctctgacct tcggccagtc taccaaggtg gagatcaaga ggaccgtggc cgcccccagc      420

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      480

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      540

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc      600

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      660

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      720

taa                                                                    723


<210>  291
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  291

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Phe Tyr Ser Ser Ile Asn Lys Asn Ser Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Ser Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  292
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  292
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctcagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggccagcca gaacatcggc tacttcctgc actggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagctcac tgcagagcgg cgtgcccagt      240

aggtttagcg gtagcggcag tggcaccgac ttcaccttga ctatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tcctacagcc ctcccctcac cttcggcgga      360

gggactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  293
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  293

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn 
        35                  40                  45              


Ile Gly Tyr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  294
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  294
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccctctgagc ctgcccgtga ccccgggtga acccgccagc      120

atcagctgca ggagcagcca aagcctgctc cacagcaacg gctacaacta cctggactgg      180

taccttcaga agcccggtca gagtccccag ctgctgatct acggcgcctc aacactgcag      240

agcggcgtgc ccgacaggtt cagcggcagc ggaagcggca ccgacttcac cctgaagatt      300

agcagggtgg aggccgagga cgtgggcgtt tactactgta tgcaggccct gcagaacccc      360

ctgaccttcg gagggggcac caaggtggag attaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  295
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  295

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ala Ser Thr Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  296
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  296
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgaca      120

atcacctgcc gagcgagcca gagtatcagc agctggctgg cctggtatca acaaaagccc      180

ggcaaggccc ccaagctgtt gatctacgac gccaccaacc tggagaccgg cgtgccgagt      240

aggttcagcg gcagtggcag cggcaccgac tttacactga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgcctgcaa gactacaact accccctgac cttcggccag      360

agcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  297
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  297

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Thr Asn Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Tyr Pro Leu Thr Phe Gly Gln Ser Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  298
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  298
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccaaag cccactgagc ctgcccgtga cccctggcga gccggccagc      120

atcagctgca ggagcagcca gagcctgttg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agccaggcca gagtccccag ctgctgatat acgccgccag caatctgcaa      240

tcaggcgtgc ccgacaggtt cagcggcagc ggctccggca ccgacttcac cctgaagatc      300

agccgcgtgg aggccgagga cgtgggcgtg tactactgta tgcaggccct gcaaacaccc      360

atcaccttcg gccaatctac caggctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  299
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  299

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Ile Thr Phe Gly Gln Ser Thr Arg 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  300
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  300
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagtca gggcatcggc agctggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgtt gatctacgcc gcgagcagtc tgcaaagcgg cgtgcccagc      240

aggttcagcg gcagcggatc tggcaccgac tttaccctca ctattagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctatacct tcccctacac cttcggccag      360

ggcaccaagt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  301
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  301

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Gly Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Thr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  302
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  302
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagtagc cttagcgcca gcgtgggcga cagggtgacg      120

atcacctgta gggcctctca gagcatcaac aactggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagttgct gatctacagt gccagcagcc tccagagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cggcaccgac ttcactctga ccatcagctc tctgcagccc      300

gaggacttcg ccacctacta ctgccaacaa agctacgaca cccccatcac atttggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  303
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  303

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asp Thr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  304
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  304
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgagc ctccccgtga cccctggcga gcccgccagc      120

atcagctgca ggagcagcga gagcctgctg atcaccaacg gcttcaacta catcgactgg      180

taccttcaga agcctggtca gtctccccag ctgcttattt acctgggctc taaccgagcc      240

gcaggcgtgc ccgacaggtt cagcggcagc gggagcggca ccgacttcac cctgaagatc      300

agccgggtgg aggccgagga cgtgggcgtg tactactgta tgcaggccct gcagactccc      360

atcaccttcg gacagggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  305
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  305

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Glu Ser 
        35                  40                  45              


Leu Leu Ile Thr Asn Gly Phe Asn Tyr Ile Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  306
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  306
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggcaagcca aagcataagt tcatggctgg cctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccttga ccatttccag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tactacagca ctctgtatac cttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  307
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  307

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Thr Leu Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  308
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  308
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagcagc ctgagcgcca gtgtgggcga cagggttacc      120

atcacgtgcc aggccagcca ggacatctca aactacctga actggtatca gcagaagccc      180

ggcaaggccc ccaaacttct gatctacggc gccagcagct tgcaaagcgg cgtgcccagc      240

aggttcagcg gcagtggcag cgggaccgac ttcaccctga cgatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag gccaacacct tccccttcac ctttggccca      360

ggtaccaagg tggacatcaa aaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  309
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  309

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
            100                 105                 110         


Thr Phe Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  310
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  310
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag tccaagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

ataacctgcc gagcgagtca gggcatcgac agctggctgg cctggtatca gcaaaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagcaaac tgcagggagg cgtgcccagc      240

aggttcagcg gctctggcag cggaaccgac tttaccctga caataagcag tctccagccc      300

gaggacttcg ccacctacta ctgccaacag ggctacagca cccccatcac cttcggccag      360

ggcactaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  311
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  311

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Asp Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Lys Leu Gln Gly Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 
            100                 105                 110         


Ser Thr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  312
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  312
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtggggga cagggtgacc      120

atcacctgcc gagccagcca gaggatcaac agctacctga attggtatca gcagaagccc      180

ggcaaggccc ccaagctgct tatctacgcc gccagcaccc tgcagagcgg cgtgccctca      240

aggttcagcg gcagcggaag cggcaccgac ttcaccctca ccatctctag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agttacagca ctccacccac cttcggcgga      360

ggcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  313
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  313

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg 
        35                  40                  45              


Ile Asn Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  314
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  314
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag tcccgccaca ctgagcgtga gccccggaga gagggcgacc      120

ctgagctgca gggccagcca gagcatcagc agcagctacc tggcctggta tcaacagaag      180

cccggtcaag cccccaggct gctcatctac ggcgccagca ctcgggccac cggcatccca      240

gcaaggttct ctggcagcgg ctccggcacc gagttcaccc tgaccatcag ctctctgcaa      300

agcgaggact tcgccgtgta ctactgccag cagtactaca ccaccccctg gacgtttggc      360

cagggaacca aggtggagat caagaggacc gtggccgccc ccagcgtgtt catcttccct      420

cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   708


<210>  315
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  315

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Tyr Thr Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  316
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  316
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgtcc ctgcccgtga cccccggaga gcccgccagc      120

atcagctgca ggagcagcca aagcctgctg cacagcaacg gctacaacta ccttgactgg      180

tatctgcaaa aaccgggcca gagtccccag ctgctgatct acctggcaag taacagggcc      240

agcggcgtgc ccgacaggtt cagcggcagc ggaagcggca cagacttcac cctgaagata      300

agccgcgtgg aggccgagga cgtgggcgtg tactactgta tgcagggcct gcagacgccc      360

cataccttcg ggggtggtac taaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  317
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  317

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Leu Gln Thr Pro His Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  318
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  318
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gtgtgggcga cagggtaacc      120

atcacctgcc gagccagtca gagcgtgggc acctggctgg cctggtatca acagaaaccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gtagcggcag cggcaccgac ttcaccctga ccattagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca gcccactgac cttcggtccc      360

ggaaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  319
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  319

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Ser Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  320
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  320
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgacagc ctggctgtga gcctgggcga gagggccacc      120

atcaactgca agagcagcca gagcgtgctg tataggagca acaacaagaa ctacctggcc      180

tggtatcagc aaaagcccgg tcagccccca aagctgctga tttactgggc cagcaccagg      240

gagagcggcg tgcccgaccg attcagcggc agcgggagcg gcacagactt caccctgacc      300

attagcagtc tgcaggcaga ggacgtggcc gtgtactact gccagcagta ctacagcatc      360

cccgtgacct tcggccaggg aaccaaggtg gagatcaaga ggaccgtggc cgcccccagc      420

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      480

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      540

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc      600

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      660

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      720

taa                                                                    723


<210>  321
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  321

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Arg Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Ile Pro Val Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  322
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  322
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag tcccagcagc ctgtccgcca gcgtgggcga ccgcgtgacc      120

atcacctgcc gagccagtca gggcgtggcc aactggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaaacttct gatatacagc gctagcaacc tgcagagcgg cgtgcccagt      240

aggttcagcg gcagcggctc tgggacagat ttcaccctta ccatcagctc attgcagccc      300

gaggacttcg ccacctacta ctgccagcaa agcagcagct tccccctgac attcggccag      360

agcaccaggc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  323
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  323

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Val Ala Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Gln Ser Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  324
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  324
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc cttagcgcca gcgtgggcga cagggtgacg      120

atcacgtgca gggccagcca gagcgtgaac aggaggctgg cgtggtatca gcagaagccc      180

ggcaaggccc ccaagctcct gatctacgcc gccagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cgggaccgac tttaccctga ccatctctag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcaa gggaacagct tccctatcac ctttggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  325
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  325

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Asn Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn 
            100                 105                 110         


Ser Phe Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  326
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  326
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga ccgcgtgacc      120

ataacttgcc gagccagcca gggcatcagc aacaacctga attggtatca gcagaagccc      180

ggcaaggccc ccaagctcct gatctacgcc gccagcagcc ttcagaccgg cgtgccgagt      240

aggttcagtg gcagcggaag cggcaccgac ttcaccctga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca caccacccac tttcggccag      360

ggaacgaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  327
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  327

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  328
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  328
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagcca gagcatcagc agctacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaaactcct gatctacgcc gcctcctctc tgcaaagcgg cgtgcccagc      240

aggttcagcg ggagcggcag cggcaccgac tttaccctta ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccttgac cttcggagga      360

ggtactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  329
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  329

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  330
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  330
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcct ccgtgggcga ccgcgtgacc      120

ataacctgcc aggccagcca gtacatcagc aactacctga actggtatca gcagaagccc      180

ggcaaggccc ccaagctgct tatctacggc gccagcaccc tgcagagcgg cgtgcctagc      240

aggttcagcg gcagcggaag cggcaccgac ttcaccctga ccatctccag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agccagagca ctcccctgac gttcggaccg      360

ggaaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  331
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  331

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Tyr 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Gln 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  332
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  332
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagcca gagcatcagc agctacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaaactcct gatctacgcc gcctcctctc tgcaaagcgg cgtgcccagc      240

aggttcagcg ggagcggcag cggcaccgac tttaccctta ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccttgac cttcggagga      360

ggtactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  333
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  333

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  334
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  334
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagt ctgagcgcca gcgtgggcga cagggtaacc      120

atcacctgta gggcctcaca gaacatcggc agctggctgg cctggtatca acagaagccc      180

ggcaaggccc ccaagctcct gatctaccga gcctccaccc tgcagagcgg cgtgcccagc      240

cggttcagcg gcagtggcag cggcaccgat ttcaccctga ccatcagcag cttgcagcct      300

gaggacttcg ccacctacta ctgccaacag agctacagca ctccatacac cttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  335
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  335

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn 
        35                  40                  45              


Ile Gly Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  336
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  336
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagt ctcagcgcca gcgtgggcga cagggtgacg      120

atcacctgta gggccagcca gaccatcagc agctacctgc actggtatca acaaaagccc      180

ggcaaggccc ccaagctgtt gatctacgcc gccagcagcc ttcagagcgg cgtgccaagc      240

aggttcagcg gcagtggcag cggcaccgac ttcacactga ccatctcaag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcaa agctacagca cacccctcag cttcggcggt      360

ggtacgaaac tggaaatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  337
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  337

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr 
        35                  40                  45              


Ile Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  338
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  338
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacgtgca gggccagcca gagcattagc agctacctga attggtatca gcagaagccc      180

ggcaaggccc ccaaactgct catctacgcc gccagtagcc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggctc aggcaccgac tttaccctga caatctcttc ccttcagccc      300

gaggacttcg ccacctacta ctgccagcaa agctacagca cccccttcac cttcggccct      360

ggaaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  339
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  339

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  340
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  340
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag ccccgctacc ctgagcgtga gtcccggcga gagggccacc      120

cttagctgca gggcaagcca gaccatcagc tcaagctacc tggcctggta tcagcagaag      180

cccggtcaag cccccaggtt gctgatctac ggcgccagca ccagggcgac cggcatcccc      240

gccaggttca gcggcagcgg aagcggcacc gagttcaccc tgactatctc cagcctgcag      300

agcgaggact tcgccgtgta ctactgccag cagtacggct caagtcccct gaccttcggg      360

ggaggaacta aggtggagat caagaggacc gtggccgccc ccagcgtgtt catcttccct      420

cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   708


<210>  341
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  341

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr 
        35                  40                  45              


Ile Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  342
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  342
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccctctgagt ctgcccgtga cccccggtga gcccgcaagc      120

atcagctgca ggagctcaca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agcccggtca aagcccccag ctgctgatat acgccgccag cagtctccag      240

ggtggtgtgc ccgacaggtt cagcggaagc ggcagcggca ccgacttcac cctgaagata      300

agcagggttg aggccgagga cgtgggcgtg tactactgta tgcaggggac ccactggccg      360

accttcggcc aaggcacaaa ggtggaaatc aagaggaccg tggccgcccc cagcgtgttc      420

atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg      480

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      540

ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc      600

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      660

acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaa         717


<210>  343
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  343

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Gly Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Thr His Trp Pro Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  344
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  344
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagcca gagcatcagc agctacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaaactcct gatctacgcc gcctcctctc tgcaaagcgg cgtgcccagc      240

aggttcagcg ggagcggcag cggcaccgac tttaccctta ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccttgac cttcggagga      360

ggtactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  345
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  345

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  346
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  346
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag tccccttagc ttgcccgtga cgccaggcga acccgccagc      120

atcagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cttggattgg      180

tacctgcaaa aacccggcca aagcccccag ctgctgatct accttggcag caacagggcc      240

agcggcgtgc ccgacaggtt cagcggctcc ggcagcggca ccgacttcac cctgaagatt      300

agccgcgtgg aggccgagga cgtgggcgtg tactactgta tgcaggccct gcagactccc      360

accttcggcc agggcaccaa ggtggagatc aagaggaccg tggccgcccc cagcgtgttc      420

atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg      480

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      540

ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc      600

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      660

acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaa         717


<210>  347
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  347

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  348
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  348
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag cccactgagt ctgcccgtga cccccggtga gcccgccagc      120

atcagctgca ggagctcaca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacttgcaga agcccggtca gtcaccgcag ctccttatct acctcggcag caacagggcc      240

agcggcgtgc ccgaccgatt cagcggaagc ggcagcggga ccgacttcac cctgaaaatc      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcaagccct gcagaccccg      360

ctgacgttcg gccagggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  349
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  349

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  350
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  350
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtggggga cagggtgacc      120

atcacgtgcc gagccagcca gggcatcagc tcatacctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgct tatctatagg gccagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cgggaccgac ttcaccttga ctatctctag tcttcagccc      300

gaggacttcg ccacctacta ctgccagcaa tcttacaaca ccccctggac cttcggccag      360

agcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  351
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  351

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asn Thr Pro Trp Thr Phe Gly Gln Ser Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  352
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  352
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgaca      120

atcacctgcc gagcgagcca aggcgtgacc tcatggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagttgct gatctacgcc gccagcaccc tgcagagcgg cgtgccgtct      240

aggttcagcg gaagcggcag tggcaccgac ttcaccctca ccatctccag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag gcgaacagct tccccctgac cttcggcggt      360

ggtactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  353
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  353

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Val Thr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  354
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  354
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagtagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc aggccagcca ggacatcagc aactacctga actggtatca acaaaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagctccc tgcagagcgg cgtgcccagc      240

aggttcagtg gcagcggctc aggaaccgac tttaccctga ccattagcag cctccagccc      300

gaggacttcg ccacctacta ctgccaacag agcttctcta gcacccccac cttcggccag      360

ggcaccaagt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  355
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  355

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe 
            100                 105                 110         


Ser Ser Thr Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  356
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  356
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ttgagcgcca gcgtgggcga tagggtgacc      120

atcacctgta gggccagcca gagcatcagt agctatctga actggtatca gcagaagccc      180

ggcaaggccc ccaaactttt gatatacgcc gcaagcaccc tgcagagggg cgtgcccagc      240

aggttcagcg ggagcggcag cggcaccgac ttcaccctga ccataagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tcctacagca cccctcttac cttcggcgga      360

gggactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  357
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  357

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Arg Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  358
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  358
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacgtgca gggccagcca ggacctgagc aaccacctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgct catctacgcc gccagcaccc tgcagagcgg cgtgcctagc      240

aggttcagcg gcagcggaag cggcaccgac tttaccctga ccatttctag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag taccacgact ggcccctgac tttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  359
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  359

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Leu Ser Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His 
            100                 105                 110         


Asp Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  360
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  360
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgagc ctgcccgtga cccccggtga gcccgccagc      120

atcagctgca ggagcagcca aagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacttgcaaa agccaggcca gtctccccag ctgctgatct acgccgcctc tagcctgcag      240

agcggcgtgc ccgacaggtt cagcggcagt ggcagcggca ccgacttcac cctgaagatt      300

agcagggtgg aggccgagga cgtgggcgtg tactattgta tgcagtccct gcaaacgcca      360

cccaccttcg gacagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  361
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  361

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ser Leu Gln Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  362
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  362
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gagggccacc      120

atcaactgca agagctcaca gagcataagc cacagcccca acacccgaga ctacctggcg      180

tggtatcagc agaagccagg ccagccccct aaactgttga tctactgggc cagcaccagg      240

gagagcggcg tgcccgatag gtttagcgga tctggaagtg gcaccgactt caccctgacc      300

atctcctctc tgcaagccga agacgtggcc gtctactact gccagcagta ctacaggttc      360

cccctggcct ttggccagag cactaaggtg gagatcaaga ggaccgtggc cgcccccagc      420

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      480

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      540

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc      600

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      660

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      720

taa                                                                    723


<210>  363
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  363

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Ile Ser His Ser Pro Asn Thr Arg Asp Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Arg Phe Pro Leu Ala Phe Gly Gln Ser Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  364
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  364
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgagc ctgcccgtca cccccggaga gcccgccagc      120

atcagctgca ggagctcaca gagcctgttg ttgaataacg gcaacaactt catcgactgg      180

tacttgcaga agcctggcca aagcccccag ctgctgattt acgccgcctc catccttcaa      240

ggaggcgttc ccgacaggtt cagcggcagc ggaagcggga ccgacttcac cctgaagatc      300

agtagggtgg aggccgagga cgtgggcgtg tactattgta tgcaggccct gcagactcct      360

cccactttcg gccagggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  365
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  365

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Leu Asn Asn Gly Asn Asn Phe Ile Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ile Leu Gln 
65                  70                  75                  80  


Gly Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  366
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  366
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag ccccgctacc ctgagcgtta gtccgggcga gagggcaaca      120

ctgagctgca gggcaagcca gagcgtgagc agctacctgg cctggtatca acagaagcca      180

ggacaggccc ccaggttgct gatctacggc gccagcacca gggccacggg catccccgcc      240

aggttcagcg gcagcggctc cggcaccgag ttcaccctca ccatcagcag cctgcagagc      300

gaggacttcg ccgtgtacta ctgccagcag tacgacaacc ggcccacctt cggccaggga      360

accaagctgg agatcaagag gaccgtggcc gcccccagcg tgttcatctt ccctcccagc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      480

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      540

agcgtgaccg agcaggactc caaggacagc acctacagcc tgagcagcac cctgaccctg      600

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggactg      660

tctagccccg tgaccaagag cttcaaccgg ggcgagtgct aa                         702


<210>  367
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  367

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp 
            100                 105                 110         


Asn Arg Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  368
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  368
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggccagcca aggcatcagc aactacctga actggtatca gcagaagccc      180

ggcaaggccc ccaaactttt gatttacgcc gccagcagtt tgcagagcgg cgtgcccagc      240

aggttcagcg gaagcggcag cggcaccgac ttcaccctca ccattagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcaa agctacagga cccccatcac tttcggccag      360

ggcactaggc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  369
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  369

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Arg Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  370
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  370
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccaaag cccactgagc ttgcccgtga cccctggcga gccggccagc      120

atcagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaaa agccaggcca gagtccccag ctgctgatat acgccgccag cagcctgcag      240

agtggcgtgc ccgaccgatt tagcggctcc ggcagcggca ccgacttcac cctgaagatc      300

agccgcgtgg aggccgagga cgtgggcgtg tactactgta tgcaagccct tcaaaccccc      360

atcaccttcg gacagggcac caggctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  371
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  371

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  372
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  372
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagtagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacgtgcc gagcgagcca gagcatctca agctggctgg cctggtatca acagaagccc      180

ggcaaggccc ccaaactgct gatctacgcc gccagcaacc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cgggaccgac tttaccctta ccatcagctc actgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccgtgac cttcggccag      360

tcaactaggc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  373
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  373

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Val Thr Phe Gly Gln Ser Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  374
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  374
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagtc cccgctgagc ctgcccgtga cccctggcga gcccgccagc      120

atcagctgca ggagcagcca aagtttgctg cacagcaacg gctacaacta tctggactgg      180

tacctgcaga agcccggaca gagcccccag ctgctgatct acctgggcag caacaggacc      240

agcggcgtgc ccgacaggtt cagtggtagc ggcagcggga ccgacttcac cctgaagatc      300

tctagggtgg aggccgagga cgtgggcgtg tactactgta tgcaagccac ccactggccc      360

ctgaccttcg gccagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  375
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  375

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Thr 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Thr His Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  376
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  376
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccaaag cccactgagc ttgcccgtga cccctggcga gccggccagc      120

atcagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaaa agccaggcca gagtccccag ctgctgatat acgccgccag cagcctgcag      240

agtggcgtgc ccgaccgatt tagcggctcc ggcagcggca ccgacttcac cctgaagatc      300

agccgcgtgg aggccgagga cgtgggcgtg tactactgta tgcaagccct tcaaaccccc      360

atcaccttcg gacagggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  377
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  377

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  378
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  378
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagtc ccctgccacc ctgagcgtga gccccggtga gagggcgacc      120

ctgtcttgca gggcgagcca gagcgtaagc agcagctacc tggcctggta tcaacagaag      180

cccggtcagg cccccaggct gctgatctac ggcgccagca ccagggccac cggcatcccc      240

gccaggttca gcggcagcgg aagcggcacc gagttcaccc tcaccatcag ctcactgcag      300

agcgaggact tcgccgtgta ctactgccag cagtacaaca actggcccct gaccttcggt      360

ggcggcacaa aagtggaaat caagaggacc gtggccgccc ccagcgtgtt catcttccct      420

cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   708


<210>  379
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  379

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  380
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  380
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

attacctgta gggccagcca gagcatcagc tcatacctga actggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gcgagcagcc ttcaaagcgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctca ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag gccaactcat tccccatcac cttcggccag      360

ggcaccaagt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705



<210>  381
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  381

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
            100                 105                 110         


Ser Phe Pro Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  382
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  382
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagttcc ctgagcgcca gcgtgggcga cagggtgacc      120

ataacctgcc gagccagcga gaacatcggc acctggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgct tatctacaag gcctctagcc tggacagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cggcaccgac ttcacactga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca ccccctacac cttcggccag      360

ggcaccaagt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  383
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  383

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn 
        35                  40                  45              


Ile Gly Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Asp Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  384
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  384
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggccagcca aggcatcggc agctggctcg cctggtatca acagaagccc      180

ggcaaggccc cgaagctcct tatccacgcc gccaccaagc tgcagaccgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctca ccatcagcag cctgcagccc      300

gaggacttcg ccacctacta ctgtcagcag agctacagca cccccttcac cttcggccct      360

gggaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  385
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  385

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Gly Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile His Ala Ala Thr Lys Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  386
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  386
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

ataacctgcc gagccagcag ggccatcggc aacaacctga gctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacacc gctagcagtc tgcaaagcgg cgtgccaagc      240

aggttcagcg gcagtggcag cggcaccgac tttaccctga ccatcagctc tctgcagccc      300

gaggacttcg ccacctacta ctgccagcaa tcttacagca ccccctacac cttcggccag      360

ggtaccaaag tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  387
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  387

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ala 
        35                  40                  45              


Ile Gly Asn Asn Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  388
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  388
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtaacc      120

atcacctgcc aggccagcca gagcatcagc agctacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaaactgtt gatatacgcc gccagtagcc tgcaaagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cggcaccgac ttcaccctga caatcagctc tctgcagccc      300

gaggacttcg ccacctacta ctgccaacag ggctacttga ccccctacac cttcggccag      360

gggaccaagt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  389
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  389

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 
            100                 105                 110         


Leu Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  390
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  390
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag cccagccact ctgagcgtaa gccccggaga gagggccacc      120

cttagctgca gggccagcca gagcgttagc tcctacctgg cctggtatca gcagaaaccg      180

ggccaggccc ccaggttgct gatctacggc gccagcacca gggcgagtgg aatccccgcc      240

aggttcagcg gctccggcag cggcaccgag ttcacactga ccattagcag cctgcagagc      300

gaggacttcg ccgtgtacta ctgccagcag tactacagct acccctggac cttcggacag      360

ggaaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  391
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  391

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Ser Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  392
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  392
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gagggccacc      120

atcaactgca agagcagcca gagcgtgctg tatagcagca acaacaagaa ctacctggcc      180

tggtatcaac agaagcccgg tcagccccca aagctgctga tctactgggc tagcaccagg      240

gagagcggcg tgcctgacag gttcagcggc agcggaagcg gcaccgactt caccctgacc      300

atctccagtt tgcaggccga ggacgtcgcc gtgtactact gccagcagta ctacggcacc      360

cctctgacct tcggaggcgg aactaaggtg gagatcaaga ggaccgtggc cgcccccagc      420

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      480

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      540

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc      600

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      660

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      720

taa                                                                    723


<210>  393
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  393

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Gly Thr Pro Leu Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  394
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  394
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgtccgcca gcgtgggcga ccgcgtgacc      120

atcacctgta gggccagcca gagcattagc agctatctga actggtatca acaaaagccc      180

ggcaaagccc ccaagctgct gatctacgac gccagctctc tgaggagcgg cgtgccaagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctga ccatttccag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca ccccacccac tttcggccaa      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  395
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  395

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Arg Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  396
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  396
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga cagggtgacg      120

atcacctgcc aggccagcca ggatatacac aactacctga attggtatca gcagaagccc      180

ggcaaggccc ccaagctcct gatctacacc gccagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggaag cggcaccgac ttcacactga ccatcagctc cctgcaaccc      300

gaggacttcg ccacctacta ctgccagcag agctacaaca tccccatcac tgtgggccag      360

ggcaccaggc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  397
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  397

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile His Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asn Ile Pro Ile Thr Val Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  398
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  398
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccaaag ccctctgagt ctgcccgtga cccctggcga gcccgccagc      120

ataagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga agcccggtca atctccacag ctgctgatct acggcgcaag cagcctgcaa      240

agcggcgtgc ccgacaggtt cagcggcagc ggctccggca ccgacttcac cctgaaaatc      300

tctagggtgg aggccgagga cgtgggcgtg tactactgta tgcagggcct gcacacaccc      360

ccgaccttcg gccagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  399
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  399

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Leu His Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  400
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  400
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtcacc      120

atcacctgca gagccagcca gagcatcagc tcatacctga actggtatca acagaagccc      180

ggcaaggccc ccaagctgct tatctacgac gccagcaacc tggagaccgg cgtgccgagc      240

aggttcagcg ggagcggcag cggaaccgac ttcaccctga ccataagtag tctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tcctacggca ctcccctgac attcggaggc      360

ggaactaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  401
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  401

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Gly Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  402
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  402
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctcagcgcca gcgtgggcga cagggttacc      120

atcacgtgca gggccagcca ggacatcaac aacttcctgg tgtggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgac gccagcaacc tggagaccgg cgtgccgagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctga ccattagtag cctgcagccc      300

gaggacttcg ccacctacta ctgtcagcag gcctacagct tccccctgac attcggtggc      360

ggcactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  403
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  403

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Asn Phe Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  404
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  404
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagtagc ctgagcgcca gcgtgggcga ccgcgtgacc      120

atcacctgta gggccagcca gagcatcagc agtcacctgc attggtatca gcaaaagccc      180

ggcaaggccc ccaagctcct gatctacgcc gcctcctccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggaag tggcaccgac ttcaccctga ccataagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagct cccccgtgac cttcggcgga      360

gggactaagg tggaaatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  405
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  405

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser His Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Ser Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  406
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  406
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccctctgagc ctgcccgtta cccccggtga gcccgccagc      120

atcagctgca ggagcagcca gtcactgctg cacagcaacg gctacaacta cctggactgg      180

tacctccaga agcctggtca gtctccacag ctgctgatct acttgggcag caacagggcc      240

agcggcgtgc ccgacaggtt cagcggcagc gggagcggca ccgactttac cctgaagata      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcagggcct gcaaacccct      360

cccaccttcg ggggaggaac taaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  407
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  407

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Leu Gln Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  408
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  408
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gagccagcca gagcatcagc tcttacctga attggtatca gcagaagccc      180

ggcaaggccc ccaagctgtt gatatacgcc gcaagcagcc tgcagagtgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctca ccattagctc tctgcaaccc      300

gaggacttcg ccacctacta ctgccagcaa acttactcca ccccctacac cttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  409
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  409

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr 
            100                 105                 110         


Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  410
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  410
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag ccccgctacc ctgagcgtga gtcccggcga gagggcgacc      120

ctcagctgca gggccagcca gggcgtgagc agctacctgg cctggtatca acagaagccg      180

ggtcaagccc ccaggctctt gatctacggc gccagcacca gggcaaccgg catccccgcc      240

aggttcagcg gcagtggcag cggcaccgag ttcacactga ccatcagcag cctgcagagc      300

gaggacttcg ccgtgtacta ctgccagcag tacaggagct tccccctgac cttcggcgga      360

ggaaccaagg tggagattaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  411
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  411

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Arg 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  412
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  412
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacttgca gggccagcca gcacatcaac agcaacctga actggtatca gcagaagccc      180

ggcaaggccc ccaagctgct catctacggc gccagtagcc tgcagagcgg cgtgcccagc      240

aggttcagcg gctcaggcag cggaactgac tttaccctga caattagcag cctccagccc      300

gaggacttcg ccacctacta ctgccagcaa agctacacca cccccttcac cttcggccct      360

ggaaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  413
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  413

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His 
        35                  40                  45              


Ile Asn Ser Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Thr Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  414
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  414
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggccagcca gagcatctca agctacctga actggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatttacgac gccagcaatt tgcagagtgg cgtgcccagc      240

aggttcagcg gcagcggaag cggcaccgac ttcaccctca ccatcagctc actgcagccc      300

gaggacttcg ccacctacta ctgtcagcaa agctacagca cacccctgac tttcggccag      360

ggcaccaggc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  415
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  415

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  416
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  416
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga ccgcgtgacc      120

ataacttgcc gagccagcca gggcatcagc aacaacctga attggtatca gcagaagccc      180

ggcaaggccc ccaagctcct gatctacgcc gccagcagcc ttcagaccgg cgtgccgagt      240

aggttcagtg gcagcggaag cggcaccgac ttcaccctga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca caccacccac tttcggccag      360

ggaacgaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  417
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  417

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  418
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  418
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgagc ctgcccgtga cccccggaga gcccgccagc      120

ataagctgca ggagcagcca aagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaga aacccggtca gagtccccag ctgctgatat acgccgcaag caccctgcag      240

tcaggcgtgc ccgacaggtt cagcggcagt ggcagcggca ctgacttcac cctgaagatc      300

agccgcgtgg aggccgagga cgtgggcgtg tactactgta tgcagggcgc tcactggccc      360

cctactttcg gccagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  419
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  419

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Ala His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  420
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  420
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggttacc      120

atcacctgcc aggccaacca gcacatcggc aactcactga attggtatca gcaaaagccc      180

ggcaaggccc ccaagctgct gatcttcgcc gccagtagac tgcagagcgg cgtgccctcc      240

aggttcagcg gaagcggcag cggcaccgac ttcaccctga ccatttcaag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacggca cccccttgac cttcggcgga      360

ggaaccaagg tggaaatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  421
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  421

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Asn Gln His 
        35                  40                  45              


Ile Gly Asn Ser Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Phe Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Gly Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  422
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  422
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgacagc ctggctgtga gcctgggcga gagggccacc      120

atcaactgca agagcagcca gagcgtgctg tatagcagca gcaacgagaa ctacctggcg      180

tggtatcaac agaaacccgg ccagcctccc aagctgctca tctactgggc ctctatcagg      240

ggcagcggcg tgcctgacag gttcagcggc tcagggagcg gcaccgactt caccctgacc      300

atcagcagcc ttcaggccga ggacgtggcc gtgtactact gccagcagta ctacagcatc      360

ccctatacct tcggccaggg caccaaggtg gagatcaaga ggaccgtggc cgcccccagc      420

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      480

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      540

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc      600

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      660

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      720

taa                                                                    723


<210>  423
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  423

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Ser Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg 
65                  70                  75                  80  


Gly Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Ile Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  424
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  424
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacacagag ccccctgagc ctgcccgtga cccctggcga gcccgccagc      120

atcagctgca ggagcagcca gtcactgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaaa agcccggtca gagtccccag ctgctgatct acgccgccag taccttgcaa      240

accggcgtgc ccgacaggtt cagcggcagt ggcagcggca ccgacttcac cctgaaaatc      300

agtagggtgg aggccgagga cgtgggcgtg tactactgta tgcaagccct gcagacccca      360

cccaccttcg gccagggaac caaggtggaa atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  425
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  425

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
65                  70                  75                  80  


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  426
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  426
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag tcccgcaacc ctgagcgtga gtcctgggga gagggcgacg      120

ctgagttgca gggccagcca gagcgtgtac agcagctacc tggcctggta tcagcaaaag      180

cccggtcagg cccccaggct gcttatctac ggcaccagca gcagggctgc gggcatcccc      240

gccaggttca gcgggagcgg cagcggcacc gagttcaccc tgaccatctc aagccttcag      300

agcgaggact ttgccgtgta ctactgccag cagtactaca gcacccccta cactttcggc      360

cagggaacca aggtggagat caagaggacc gtggccgccc ccagcgtgtt catcttccct      420

cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   708


<210>  427
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  427

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Tyr Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Thr Ser Ser Arg Ala Ala Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  428
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  428
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagtc acccctgagt ctgcccgtga ctcccggcga gcccgcctca      120

atcagctgca ggagcagcca gagcctgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaaa agcccggaca gagtccacag ctgcttatct acgccgccag cagcctgcag      240

agcggcgtgc ccgacaggtt cagcggcagc ggtagcggca ccgacttcac cctgaaaatc      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcaggccct ggagacacct      360

cccacattcg gacagggcac caagctggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  429
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  429

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Glu Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  430
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  430
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccctgagc ctgcccgtga cccccggaga gcccgccagc      120

atcagctgca ggagcagcca gtcactgctg cacagcaacg gctacaacta cctggactgg      180

tacctgcaaa aacccggcca atcaccccag ctgctgatct acgccgcctc cagcctgcag      240

agcggcgtgc ccgacaggtt cagtggttca ggcagcggca ccgacttcac cctgaagata      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcagggcgc acattggcct      360

cccacattcg gccagggcac taaggtggaa atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  431
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  431

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Ala His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  432
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  432
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagcca gagcatcagc agctacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaaactcct gatctacgcc gcctcctctc tgcaaagcgg cgtgcccagc      240

aggttcagcg ggagcggcag cggcaccgac tttaccctta ccatcagtag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccttgac cttcggagga      360

ggtactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  433
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  433

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  434
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  434
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccctctagc ctcagcgcca gcgtgggcga ccgcgtgacc      120

ataacttgcc gagccagcca gggcatcagc aacaacctga attggtatca gcagaagccc      180

ggcaaggccc ccaagctcct gatctacgcc gccagcagcc ttcagaccgg cgtgccgagt      240

aggttcagtg gcagcggaag cggcaccgac ttcaccctga ccatcagctc cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag agctacagca caccacccac tttcggccag      360

ggaacgaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  435
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  435

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  436
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  436
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtaacc      120

attacctgcc gagccagcca gagcatcggc agctggatgg cctggtatca acaaaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gccagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctga caatctcaag tctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacacca cccccatcac cttcggccct      360

ggaaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  437
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  437

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Ser Trp Met Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Thr Thr Pro Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  438
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  438
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagtagc ctctcagcca gcgtgggcga cagggtgacc      120

attacgtgta gggccagcca gaccatctca acctacctga actggtatca acaaaagccc      180

ggcaaggccc ccaagctgct tatctacgac gccagcaacc tggagaccgg cgtgcccagc      240

aggttcagcg gcagcggctc cggcaccgac ttcacgctga ccatcagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccctatcac ctttggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  439
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  439

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr 
        35                  40                  45              


Ile Ser Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  440
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  440
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccctccagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc aggccaccca ggacatcgcc gactacctga actggtatca gcaaaagccc      180

ggcaaggccc ccaagctgct gatctacaag gcctcaagcc ttgagagcgg cgtgcccagc      240

aggttcagcg gcagcggtag cgggaccgac ttcactctga ccattagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag agctacagca cccccacctt tggccctgga      360

accaaggtgg acatcaagag gaccgtggcc gcccccagcg tgttcatctt ccctcccagc      420

gacgagcagc tgaagtctgg caccgccagc gtggtgtgcc tgctgaacaa cttctacccc      480

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agagcggcaa cagccaggag      540

agcgtgaccg agcaggactc caaggacagc acctacagcc tgagcagcac cctgaccctg      600

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggactg      660

tctagccccg tgaccaagag cttcaaccgg ggcgagtgct aa                         702


<210>  441
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  441

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Thr Gln Asp 
        35                  40                  45              


Ile Ala Asp Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Thr Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  442
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  442
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag tccactgagc ctgcccgtga ccccgggaga acccgccagc      120

atcagctgca ggagctcaca gagccttctg catagcaacg gctacaacta cctcgactgg      180

tacctgcaga aacccggaca aagcccccag ctgttgatct acctgggcag caacagggcc      240

agcggcgtgc ccgacaggtt cagcggcagc ggaagcggca ccgacttcac cctgaagatc      300

agcagggtgg aggccgagga cgtgggcgtg tactactgta tgcaaggcac ccactggccc      360

ccaaccttcg ggggaggaac taaggtggag atcaagagga ccgtggccgc ccccagcgtg      420

ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg      480

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa      720


<210>  443
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  443

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Gly Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  444
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  444
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagcgagcca gagcatcagc aactggctgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgct tatctacgac ggcagcaacc tgggcaccgg cgtacccagc      240

aggttcagcg gcagtggcag cggcactgac ttcaccttga ccattagcag tctgcagccc      300

gaggacttcg ccacctacta ctgcttgcag gactttacct accccctgac cttcggcgga      360

gggaccaaag tggaaatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  445
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  445

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Gly Ser Asn Leu Gly Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Phe 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  446
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  446
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgcc gagccagcca gagcatcagc agctacctga attggtatca gcaaaagccc      180

ggcaaggccc ccaagctgtt gatctacgac gcaagcagcc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagtggcag cggcaccgac ttcaccctca ccatcagctc tctgcaaccc      300

gaggacttcg ccacctacta ctgccagcaa acttaccata ccccctggac cttcggccag      360

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  447
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  447

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr 
            100                 105                 110         


His Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  448
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  448
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggcctcaca gagcgtgagc agctggctgg cctggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatttacgcc gccagcaatt tgcagagtgg cgtgcccagc      240

aggttcagcg gcagcggaag cggcaccgac ttcaccctca ccatcagctc actgcagccc      300

gaggacttcg ccacctacta ctgtcagcaa agctacgacg tcccctggac cttcggccag      360

ggcactaggc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  449
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  449

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asp Val Pro Trp Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  450
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  450
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gagatcgtga tgacccagag tcccgctacc ctgagcgtga gccccggtga gagggccacc      120

cttagctgca gggccagcca gggtatcccc agcaacagcc tggcgtggta tcaacagaag      180

cccggacagg cccccaggtt gctgatatac ggcaccagcg ccagggctag cggcatcccc      240

gccaggttca gcgggagcgg cagcggcacc gagttcaccc tgaccatcag cagcctgcag      300

agcgaggact tcgccgtgta ctactgccag cagtactaca gcaccccctg gaccttcggc      360

caaggaacca aggtggagat caagaggacc gtggccgccc ccagcgtgtt catcttccct      420

cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct gaacaacttc      480

tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag cagcaccctg      600

accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt gacccaccag      660

ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaa                   708


<210>  451
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  451

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Pro Ser Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Thr Ser Ala Arg Ala Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  452
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  452
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc      120

ataacctgcc aggccagcca ggacatcagc aactacctga actggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgac gccagcaacc ttcaagctgg ggtgccgagc      240

aggttcagcg gaagcggcag cggcaccgac ttcactctga ccatcagtag cctccagccc      300

gaggacttcg ccacctacta ctgccaacaa agctatagta gcccaatcac ctttggccag      360

ggcaccaggt tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  453
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  453

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Gln Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
            100                 105                 110         


Ser Ser Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  454
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  454
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagggtgacc      120

atcacctgta gggccagcca gggcatcagc aacaacctga actggtatca acagaagccc      180

ggcaaggccc ccaagctgct gatctacgcc gcctcaagcc tgcagagcgg cgtgcccagc      240

cgattcagcg gaagcggcag cgggaccgac ttcactctga ccattagcag tctgcagccc      300

gaggacttcg ccacctacta ctgccagcag ggcttcaact tccccctgac tttcggaggc      360

ggaactaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  455
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  455

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Asn Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe 
            100                 105                 110         


Asn Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  456
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  456
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatcgtga tgacccagag ccccgatagc ctggctgtga gcctgggcga gagggccacc      120

atcaactgca agagcagcca gagcgtgctt tacagcagca acaacaggaa ctacctggcc      180

tggtatcagc agaagcccgg tcaacctccc aagctgctca tctactgggc cagcaccagg      240

gagagcggcg tgccggacag gttcagcggc agcgggagcg gcaccgactt caccctgacc      300

atcagctcac tccaggccga ggacgtggcc gtgtactact gtcagcagta ctacagcgtg      360

cccttgacct tcggccaggg caccaaggtg gagatcaaga ggaccgtggc cgcccccagc      420

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      480

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      540

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc      600

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc      660

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc      720

taa                                                                    723


<210>  457
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 light chain

<400>  457

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Leu Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  458
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  458

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  459
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  459

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  460
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  460

Ala Lys Ser Ile Leu Gly Gly Arg Ile Phe Gly Gly Tyr Phe Asp Leu 
1               5                   10                  15      


<210>  461
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  461

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  462
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  462

Ala Ala Ser 
1           


<210>  463
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  463

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  464
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  464

Gly Tyr Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  465
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  465

Ile Ile Pro Ile Val Gly Thr Ala 
1               5               


<210>  466
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  466

Ala Arg Ala Gly Gly Gly Asp Tyr Lys Ser Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  467
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  467

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  468
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  468

Trp Ala Ser 
1           


<210>  469
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  469

Gln Gln Tyr Tyr Thr Ser Pro Thr 
1               5               


<210>  470
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  470

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  471
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  471

Ile Ile Pro Ile Phe Gly Thr Pro 
1               5               


<210>  472
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  472

Ala Arg Val Arg Ala Lys Arg Pro Asn Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  473
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  473

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  474
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  474

Leu Gly Ser 
1           


<210>  475
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  475

Met Gln Ser Ile Gln Ile Pro Pro Thr 
1               5                   


<210>  476
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  476

Gly Gly Thr Phe Ser Thr Phe Gly 
1               5               


<210>  477
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  477

Ile Ile Pro Ile Leu Ala Thr Thr 
1               5               


<210>  478
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  478

Ala Ser Gly Asp Tyr Tyr Asp Ser Ser Gly Tyr Tyr Gly Tyr Phe Gln 
1               5                   10                  15      


His 
    


<210>  479
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  479

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  480
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  480

Gly Ala Ser 
1           


<210>  481
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  481

Gln Gln Ser Tyr Ser Ile Pro Phe Thr 
1               5                   


<210>  482
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  482

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  483
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  483

Ile Ser Ser Asp Thr Thr Tyr Lys 
1               5               


<210>  484
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  484

Ala Arg Glu Val Asp Thr Ala Met Lys Asn 
1               5                   10  


<210>  485
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  485

Gln Gly Ile Gly Asn Asp 
1               5       


<210>  486
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  486

Ala Ala Ser 
1           


<210>  487
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  487

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  488
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  488

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  489
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  489

Ile Gly Gly Ser Gly Ala Gly Thr 
1               5               


<210>  490
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  490

Ala Arg Leu Ser Thr Val Thr Arg Gly Phe Asp Tyr 
1               5                   10          


<210>  491
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  491

Gln Ser Ile Ser Asn Trp 
1               5       


<210>  492
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  492

Ser Ala Ser 
1           


<210>  493
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  493

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  494
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  494

Gly Tyr Thr Phe Thr Asp Ser Tyr 
1               5               


<210>  495
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  495

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  496
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  496

Ala Arg Gly Val Phe Asp Tyr Gly Asp Tyr Gly Tyr Tyr Tyr His Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  497
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  497

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  498
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  498

Gly Ala Ser 
1           


<210>  499
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  499

Met Gln Gly Thr Gln Trp Pro Thr 
1               5               


<210>  500
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  500

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  501
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  501

Ile Ser Pro Asp Asn Gly Asn Thr 
1               5               


<210>  502
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  502

Ala Arg Leu Ala Tyr Asp Thr Gly Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  503
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  503

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  504
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  504

Ala Ala Ser 
1           


<210>  505
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  505

Met Gln Gly Thr His Trp Pro Leu Thr 
1               5                   


<210>  506
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  506

Gly Phe Ala Phe Ser Ser His Trp 
1               5               


<210>  507
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  507

Ile Ser Ser Gly Ser His Ser Ile 
1               5               


<210>  508
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  508

Ala Arg Glu Ala Gly Thr Ser Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  509
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  509

Gln Asp Ile Arg Asn Tyr 
1               5       


<210>  510
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  510

Lys Ala Ser 
1           


<210>  511
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  511

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  512
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  512

Gly Gly Thr Phe Gly Tyr Tyr Ala 
1               5               


<210>  513
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  513

Ile Ile Pro Met Val Gly Thr Gly 
1               5               


<210>  514
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  514

Ala Gly Val Glu Val Gly Ala Thr Arg Gly Tyr Phe Gln His 
1               5                   10                  


<210>  515
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  515

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  516
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  516

Ala Ala Ser 
1           


<210>  517
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  517

Met Gln Gly Thr His Trp Pro Thr Thr 
1               5                   


<210>  518
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  518

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  519
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  519

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  520
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  520

Ala Met Asp Thr Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  521
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  521

Glu Asp Ile Ala Asn Asn 
1               5       


<210>  522
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  522

Ala Ala Ser 
1           


<210>  523
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  523

Gln Gln Gly Tyr Asn Ile Pro Phe Thr 
1               5                   


<210>  524
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  524

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  525
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  525

Ile Asp Pro Ser Gly Gly Gly Thr 
1               5               


<210>  526
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  526

Ala Lys Asp Ile Val Val Val Pro Ala Ala Ile Ala Asn Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  527
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  527

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  528
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  528

Gly Ala Ser 
1           


<210>  529
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  529

Gln Gln Ser Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  530
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  530

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  531
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  531

Ile Met Pro Leu Phe Gly Thr Ile 
1               5               


<210>  532
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  532

Ala Arg Gly Arg Val Gly Ala Thr Asp Tyr 
1               5                   10  


<210>  533
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  533

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  534
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  534

Leu Ala Ser 
1           


<210>  535
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  535

Met Gln Ala Leu Gln Thr Pro Val Thr 
1               5                   


<210>  536
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  536

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  537
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  537

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  538
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  538

Ala Arg Asp Thr Val Ser Met Asp Val 
1               5                   


<210>  539
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  539

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  540
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  540

Asp Ala Ser 
1           


<210>  541
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  541

Met Gln Gly Ala His Trp Pro Pro Thr 
1               5                   


<210>  542
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  542

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  543
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  543

Ile Ile Pro Met Phe Gly Thr Thr 
1               5               


<210>  544
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  544

Ala Thr Val Ala Ala Ala Gly Pro Asn Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  545
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  545

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  546
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  546

Ala Ala Ser 
1           


<210>  547
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  547

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  548
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  548

Gly Tyr Thr Phe Thr Ser His Tyr 
1               5               


<210>  549
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  549

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  550
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  550

Ala Arg Ala Gly Ile Gly Tyr Leu Ala Ala His Asp Leu Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  551
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  551

Gln Ser Val Ser Ser Asn 
1               5       


<210>  552
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  552

Gly Ala Ser 
1           


<210>  553
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  553

Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  554
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  554

Gly Tyr Thr Phe Thr Asp Ser Phe 
1               5               


<210>  555
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  555

Ile Asn Pro Gly Thr Gly Ala Thr 
1               5               


<210>  556
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  556

Ala Arg Ser Ser Asp Tyr Asp Ser Ser Asp Tyr 
1               5                   10      


<210>  557
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  557

Gln Ser Ile Ser Thr Trp 
1               5       


<210>  558
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  558

Gly Ala Ser 
1           


<210>  559
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  559

Gln Gln Ser Tyr Asn Ser Pro Tyr Thr 
1               5                   


<210>  560
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  560

Gly Tyr Thr Phe Thr Ser Phe Gly 
1               5               


<210>  561
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  561

Ile Ile Pro Thr Leu Gly Thr Ala 
1               5               


<210>  562
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  562

Ala Gly Gly Ala Ala Ala Gly Pro Asp Lys Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  563
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  563

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  564
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  564

Ala Ala Ser 
1           


<210>  565
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  565

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  566
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  566

Gly Phe Ser Phe Ser His Ala Trp 
1               5               


<210>  567
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  567

Ile His Ser Gly Gly Ser Thr 
1               5           


<210>  568
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  568

Ala Arg Ile Gly Lys Gly Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  569
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  569

Gln Asp Ile Gly Ser Trp 
1               5       


<210>  570
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  570

Ala Ala Ser 
1           


<210>  571
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  571

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  572
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  572

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  573
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  573

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  574
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  574

Ala Ser Gly Phe Tyr Ser Asn Asp Leu Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  575
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  575

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  576
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  576

Asp Ala Ser 
1           


<210>  577
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  577

Gln Gln Thr Tyr Ala Ile Pro Leu Thr 
1               5                   


<210>  578
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  578

Gly Tyr Thr Phe Ser Asn His Tyr 
1               5               


<210>  579
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  579

Val Asn Pro Thr Ser Gly Asn Thr 
1               5               


<210>  580
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  580

Ala Arg Asp Leu Gly Val Thr Tyr Phe Asp Leu 
1               5                   10      


<210>  581
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  581

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  582
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  582

Glu Ala Ser 
1           


<210>  583
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  583

Leu Gln Asp Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  584
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  584

Gly Phe Lys Phe Arg Thr Phe Trp 
1               5               


<210>  585
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  585

Ile Ser Asn Gly Gly Asp Ala Thr 
1               5               


<210>  586
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  586

Ala Arg Val Asp Cys Ser Gly Gly Ser Cys Tyr Leu Gly Tyr 
1               5                   10                  


<210>  587
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  587

Glu Ser Ile Gly Arg Tyr 
1               5       


<210>  588
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  588

Gly Thr Ser 
1           


<210>  589
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  589

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  590
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  590

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  591
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  591

Ile Ser Ser Arg Ser Ser Tyr Ile 
1               5               


<210>  592
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  592

Ala Arg Glu Gly Asn Gly Met Asp Val 
1               5                   


<210>  593
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  593

Gln Asp Ile Gly Ser Tyr 
1               5       


<210>  594
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  594

Ala Ala Ser 
1           


<210>  595
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  595

Leu Gln Ser Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  596
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  596

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  597
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  597

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  598
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  598

Ala Lys Thr Pro Leu Gly Arg Gly Tyr Gly Leu Phe Asp Tyr 
1               5                   10                  


<210>  599
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  599

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  600
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  600

Leu Ala Ser 
1           


<210>  601
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  601

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  602
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  602

Gly Gly Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  603
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  603

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  604
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  604

Ala Arg Ser Thr Asn Ala Leu Asp Tyr 
1               5                   


<210>  605
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  605

Gln Gly Ile Arg Ser Asn 
1               5       


<210>  606
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  606

Ile Val Ser 
1           


<210>  607
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  607

Leu Gln His Asn Ser Asn Pro Pro Thr 
1               5                   


<210>  608
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  608

Gly Tyr Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  609
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  609

Ile Leu Pro Val Phe Gly Thr Ala 
1               5               


<210>  610
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  610

Ala Arg Gly Phe Gly Tyr Phe Asp Tyr 
1               5                   


<210>  611
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  611

Gln Ser Val Phe Tyr Ser Ser Ile Asn Lys Asn Ser 
1               5                   10          


<210>  612
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  612

Trp Ala Ser 
1           


<210>  613
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  613

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  614
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  614

Gly Tyr Thr Phe Thr Gly Gln Tyr 
1               5               


<210>  615
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  615

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  616
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  616

Ala Gly Ser Tyr Tyr Pro Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  617
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  617

Gln Asn Ile Gly Tyr Phe 
1               5       


<210>  618
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  618

Ala Ala Ser 
1           


<210>  619
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  619

Gln Gln Ser Tyr Ser Pro Pro Leu Thr 
1               5                   


<210>  620
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  620

Gly Gly Thr Phe Gly Asn Tyr Gly 
1               5               


<210>  621
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  621

Ile Ile Pro Val Phe Gly Thr Thr 
1               5               


<210>  622
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  622

Ala Arg Gly Leu Arg Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  623
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  623

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  624
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  624

Gly Ala Ser 
1           


<210>  625
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  625

Met Gln Ala Leu Gln Asn Pro Leu Thr 
1               5                   


<210>  626
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  626

Gly Gly Thr Phe Thr Gly Tyr Phe 
1               5               


<210>  627
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  627

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  628
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  628

Ala Arg Glu Gly Gln Gly Val Val Pro Val Asp Tyr 
1               5                   10          


<210>  629
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  629

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  630
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  630

Asp Ala Thr 
1           


<210>  631
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  631

Leu Gln Asp Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  632
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  632

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  633
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  633

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  634
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  634

Ala Lys Leu Ser Gly Ser Ser Gly Ser Trp Asp Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  635
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  635

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  636
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  636

Ala Ala Ser 
1           


<210>  637
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  637

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  638
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  638

Gly Gly Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  639
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  639

Ile Ile Pro Met Phe Gly Thr Ala 
1               5               


<210>  640
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  640

Ala Gly Glu Arg Gly Tyr Gly Ser Leu Asp Tyr 
1               5                   10      


<210>  641
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  641

Gln Gly Ile Gly Ser Trp 
1               5       


<210>  642
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  642

Ala Ala Ser 
1           


<210>  643
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  643

Gln Gln Ser Tyr Thr Phe Pro Tyr Thr 
1               5                   


<210>  644
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  644

Gly Phe Thr Phe Ser Asn Ser Asp 
1               5               


<210>  645
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  645

Ile Ser Ser Ser Ser Gly Tyr Thr 
1               5               


<210>  646
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  646

Ala Arg Ala Asn Asn Asn Trp Asn Phe Tyr Phe Asp Tyr 
1               5                   10              


<210>  647
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  647

Gln Ser Ile Asn Asn Trp 
1               5       


<210>  648
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  648

Ser Ala Ser 
1           


<210>  649
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  649

Gln Gln Ser Tyr Asp Thr Pro Ile Thr 
1               5                   


<210>  650
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  650

Gly Asp Thr Phe Asp Thr Tyr Ala 
1               5               


<210>  651
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  651

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  652
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  652

Ala Arg Ser Arg Gly Arg Gly Tyr Ser Tyr Gly Ser Gly Leu Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  653
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  653

Glu Ser Leu Leu Ile Thr Asn Gly Phe Asn Tyr 
1               5                   10      


<210>  654
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  654

Leu Gly Ser 
1           


<210>  655
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  655

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  656
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  656

Gly Gln Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  657
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  657

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  658
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  658

Ala Arg Glu Thr Leu Glu Gln Gln Leu Pro Phe Asp Tyr 
1               5                   10              


<210>  659
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  659

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  660
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  660

Ala Ala Ser 
1           


<210>  661
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  661

Gln Gln Tyr Tyr Ser Thr Leu Tyr Thr 
1               5                   


<210>  662
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  662

Ala Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  663
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  663

Ile Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  664
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  664

Ala Arg Gly Gly Ser Gly Trp Pro Thr 
1               5                   


<210>  665
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  665

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  666
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  666

Gly Ala Ser 
1           


<210>  667
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  667

Gln Gln Ala Asn Thr Phe Pro Phe Thr 
1               5                   


<210>  668
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  668

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  669
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  669

Ile Asp Pro Asn Ser Gly Gly Thr 
1               5               


<210>  670
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  670

Ala Arg Asp Asp Trp Phe Ser Gly Asp Leu Asp Tyr 
1               5                   10          


<210>  671
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  671

Gln Gly Ile Asp Ser Trp 
1               5       


<210>  672
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  672

Ala Ala Ser 
1           


<210>  673
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  673

Gln Gln Gly Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  674
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  674

Gly Phe Thr Phe Thr Asp Ala Trp 
1               5               


<210>  675
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  675

Ile Ser Val Ser Val Gly Val Thr 
1               5               


<210>  676
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  676

Ala Thr Ile Gly Ser Met Ala Thr Ile Arg Lys Gly Ala Thr Asp Ala 
1               5                   10                  15      


Phe Asp Ile 
            


<210>  677
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  677

Gln Arg Ile Asn Ser Tyr 
1               5       


<210>  678
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  678

Ala Ala Ser 
1           


<210>  679
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  679

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  680
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  680

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  681
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  681

Ile Ile Pro Met Phe Gly Ile Ala 
1               5               


<210>  682
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  682

Ala Arg Ser Ser Arg Ser Ser Ser Trp Tyr Asn Trp Tyr Phe Asp Leu 
1               5                   10                  15      


<210>  683
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  683

Gln Ser Ile Ser Ser Ser Tyr 
1               5           


<210>  684
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  684

Gly Ala Ser 
1           


<210>  685
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  685

Gln Gln Tyr Tyr Thr Thr Pro Trp Thr 
1               5                   


<210>  686
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  686

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  687
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  687

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  688
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  688

Ala Arg Ala Arg Phe Gly Ala Val Asp Tyr 
1               5                   10  


<210>  689
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  689

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  690
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  690

Leu Ala Ser 
1           


<210>  691
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  691

Met Gln Gly Leu Gln Thr Pro His Thr 
1               5                   


<210>  692
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  692

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  693
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  693

Ile Asn Pro Ser Ala Asp Thr Thr 
1               5               


<210>  694
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  694

Ala Arg Thr Pro Gly Asn Tyr Gly Gly Asn Ser Leu Gly Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val 
            20          


<210>  695
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  695

Gln Ser Val Gly Thr Trp 
1               5       


<210>  696
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  696

Ala Ala Ser 
1           


<210>  697
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  697

Gln Gln Ser Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  698
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  698

Gly Tyr Thr Phe Thr Asp Tyr Gln 
1               5               


<210>  699
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  699

Ile Asn Pro Gly Gly Gly Ser Thr 
1               5               


<210>  700
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  700

Ala Arg Gly Gly Val Glu Tyr Ser Ser Ser Trp Asp Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  701
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  701

Gln Ser Val Leu Tyr Arg Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  702
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  702

Trp Ala Ser 
1           


<210>  703
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  703

Gln Gln Tyr Tyr Ser Ile Pro Val Thr 
1               5                   


<210>  704
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  704

Gly Tyr Thr Phe Asn Ser His Trp 
1               5               


<210>  705
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  705

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  706
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  706

Ala Ser Gly Asp Tyr Pro Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  707
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  707

Gln Gly Val Ala Asn Trp 
1               5       


<210>  708
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  708

Ser Ala Ser 
1           


<210>  709
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  709

Gln Gln Ser Ser Ser Phe Pro Leu Thr 
1               5                   


<210>  710
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  710

Gly Tyr Thr Phe Ser Ser Tyr Tyr 
1               5               


<210>  711
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  711

Ile Asn Pro His Ser Gly Gly Thr 
1               5               


<210>  712
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  712

Ala Arg Asp Ser Ser Gly Met Gly Ala Thr Ile Gly Tyr 
1               5                   10              


<210>  713
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  713

Gln Ser Val Asn Arg Arg 
1               5       


<210>  714
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  714

Ala Ala Ser 
1           


<210>  715
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  715

Gln Gln Gly Asn Ser Phe Pro Ile Thr 
1               5                   


<210>  716
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  716

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  717
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  717

Ile Ser Gly Thr Ala Ile Asn Thr 
1               5               


<210>  718
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  718

Ala Arg Val Arg Arg Asp Ser Ser Gly Gly Gly Ala Phe Asp Ile 
1               5                   10                  15  


<210>  719
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  719

Gln Gly Ile Ser Asn Asn 
1               5       


<210>  720
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  720

Ala Ala Ser 
1           


<210>  721
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  721

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  722
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  722

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  723
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  723

Ile Val Pro Ile Phe Glu Thr Ala 
1               5               


<210>  724
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  724

Ala Arg Asp Thr Pro Asn Phe Asp Tyr 
1               5                   


<210>  725
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  725

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  726
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  726

Ala Ala Ser 
1           


<210>  727
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  727

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  728
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<400>  728

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  729
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  729

Ile Ser Gly Thr Ser Asn Tyr Met 
1               5               


<210>  730
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  730

Ala Arg Asp Arg Gly Phe Leu Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  731
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  731

Gln Tyr Ile Ser Asn Tyr 
1               5       


<210>  732
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  732

Gly Ala Ser 
1           


<210>  733
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  733

Gln Gln Ser Gln Ser Thr Pro Leu Thr 
1               5                   


<210>  734
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  734

Gly Tyr Thr Phe Thr Asn Tyr Tyr 
1               5               


<210>  735
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  735

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  736
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  736

Ala Arg Gly Gly Tyr Tyr Asp Ser Ser Gln Phe Asp Ile 
1               5                   10              


<210>  737
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  737

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  738
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  738

Ala Ala Ser 
1           


<210>  739
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  739

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  740
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  740

Glu Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  741
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  741

Ile Ser Gly Thr Ser Arg Tyr Thr 
1               5               


<210>  742
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  742

Ala Arg Asp Gln Asp Gly Arg Leu Asp Tyr 
1               5                   10  


<210>  743
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  743

Gln Asn Ile Gly Ser Trp 
1               5       


<210>  744
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  744

Arg Ala Ser 
1           


<210>  745
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  745

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  746
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  746

Gly Gly Thr Leu Ser Ser Tyr Ala 
1               5               


<210>  747
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  747

Ile Ser Pro Tyr Asn Gly Lys Ala 
1               5               


<210>  748
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  748

Ala Ile Arg Ser Ile Ala Ala Arg Glu Gly Val Tyr Tyr Tyr Tyr Met 
1               5                   10                  15      


Asp Val 
        


<210>  749
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  749

Gln Thr Ile Ser Ser Tyr 
1               5       


<210>  750
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  750

Ala Ala Ser 
1           


<210>  751
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  751

Gln Gln Ser Tyr Ser Thr Pro Leu Ser 
1               5                   


<210>  752
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  752

Gly Ala Ala Phe Asn Thr Val Ala 
1               5               


<210>  753
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  753

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  754
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  754

Ala Arg Thr Pro Ala Ala Ala Gly Thr Val Tyr Phe Asp Tyr 
1               5                   10                  


<210>  755
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  755

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  756
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  756

Ala Ala Ser 
1           


<210>  757
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  757

Gln Gln Ser Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  758
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  758

Gly Gly Ser Phe Ser Arg Ser Ser 
1               5               


<210>  759
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  759

Ile Ile Pro Ile Phe Gly Ala Pro 
1               5               


<210>  760
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  760

Ala Arg Asp His Pro His Cys Ser Ser Thr Ser Cys Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  761
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  761

Gln Thr Ile Ser Ser Ser Tyr 
1               5           


<210>  762
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  762

Gly Ala Ser 
1           


<210>  763
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  763

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  764
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  764

Gly Gly Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  765
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  765

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  766
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  766

Ala Arg Leu Ser Thr Val Thr Thr Arg Pro Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  767
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<400>  767

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  768
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  768

Ala Ala Ser 
1           


<210>  769
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  769

Met Gln Gly Thr His Trp Pro Thr 
1               5               


<210>  770
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  770

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  771
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  771

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  772
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  772

Ala Arg Val Pro Ala Asp Tyr Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  773
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  773

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  774
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  774

Ala Ala Ser 
1           


<210>  775
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  775

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  776
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  776

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  777
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  777

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  778
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  778

Ala Arg Gly Arg Phe Gly Ser Arg Asp Val 
1               5                   10  


<210>  779
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  779

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  780
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  780

Leu Gly Ser 
1           


<210>  781
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  781

Met Gln Ala Leu Gln Thr Pro Thr 
1               5               


<210>  782
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  782

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  783
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  783

Ile Ile Pro Val Ile Asp Thr Thr 
1               5               


<210>  784
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  784

Ala Arg Ala Ser Gly Tyr Pro Phe Gly Arg Trp Phe Asp Pro 
1               5                   10                  


<210>  785
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  785

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  786
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  786

Leu Gly Ser 
1           


<210>  787
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  787

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  788
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  788

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  789
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  789

Ile Ser Ser Asp Ser Tyr Tyr Lys 
1               5               


<210>  790
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  790

Ala Lys Gly Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Leu Asp Tyr 
1               5                   10                  15  


<210>  791
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  791

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  792
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  792

Arg Ala Ser 
1           


<210>  793
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  793

Gln Gln Ser Tyr Asn Thr Pro Trp Thr 
1               5                   


<210>  794
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  794

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  795
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  795

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  796
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  796

Ala Arg Gly Asp Tyr Tyr Tyr Gly Ser Gly Ser Asp Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  797
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  797

Gln Gly Val Thr Ser Trp 
1               5       


<210>  798
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  798

Ala Ala Ser 
1           


<210>  799
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  799

Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  800
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  800

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  801
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  801

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  802
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  802

Ala Arg Pro Arg Leu Ala Val Ala Gly Gly Trp Tyr Phe Asp Leu 
1               5                   10                  15  


<210>  803
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  803

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  804
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  804

Ala Ala Ser 
1           


<210>  805
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  805

Gln Gln Ser Phe Ser Ser Thr Pro Thr 
1               5                   


<210>  806
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  806

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  807
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  807

Ile Ser Ser Asp Ser Ser Tyr Lys 
1               5               


<210>  808
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  808

Ala Arg Asp Gly Leu Arg Trp Asp Ala Phe Asp Ile 
1               5                   10          


<210>  809
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  809

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  810
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  810

Ala Ala Ser 
1           


<210>  811
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  811

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  812
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  812

Gly Tyr Thr Phe Thr Asp His Tyr 
1               5               


<210>  813
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  813

Ile Asn Pro Ser Gly Gly Tyr Thr 
1               5               


<210>  814
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  814

Ala Arg Asp Arg Phe Arg Glu Leu Leu Gly Ser Arg Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  815
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  815

Gln Asp Leu Ser Asn His 
1               5       


<210>  816
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  816

Ala Ala Ser 
1           


<210>  817
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  817

Gln Gln Tyr His Asp Trp Pro Leu Thr 
1               5                   


<210>  818
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  818

Gly Gly Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  819
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  819

Ile Ile Pro Val Phe Gly Thr Ala 
1               5               


<210>  820
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  820

Ala Arg Val Thr Ala Met Gly Val Gly Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  821
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  821

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  822
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  822

Ala Ala Ser 
1           


<210>  823
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  823

Met Gln Ser Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  824
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  824

Gly Tyr Ile Phe Thr Asn Tyr Trp 
1               5               


<210>  825
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  825

Ile Ile Pro Ile Phe Glu Thr Ala 
1               5               


<210>  826
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  826

Ala Arg Leu Gly Asp Arg Gly Asp Phe Asp Tyr 
1               5                   10      


<210>  827
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  827

Gln Ser Ile Ser His Ser Pro Asn Thr Arg Asp Tyr 
1               5                   10          


<210>  828
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  828

Trp Ala Ser 
1           


<210>  829
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  829

Gln Gln Tyr Tyr Arg Phe Pro Leu Ala 
1               5                   


<210>  830
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  830

Gly Gly Thr Phe Ser Ser Asp Ala 
1               5               


<210>  831
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  831

Ile Val Pro Ala Phe Gly Thr Ala 
1               5               


<210>  832
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  832

Ala Arg Ser Ser Ser Ser Trp Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  833
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  833

Gln Ser Leu Leu Leu Asn Asn Gly Asn Asn Phe 
1               5                   10      


<210>  834
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  834

Ala Ala Ser 
1           


<210>  835
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  835

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  836
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  836

Gly Tyr Phe Phe Thr Ser Tyr Gly 
1               5               


<210>  837
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  837

Val Ile Pro Ile Ser Gly Thr Ala 
1               5               


<210>  838
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  838

Ala Arg Asp Glu Asn Gly Ala Phe Asp Ile 
1               5                   10  


<210>  839
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  839

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  840
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  840

Gly Ala Ser 
1           


<210>  841
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  841

Gln Gln Tyr Asp Asn Arg Pro Thr 
1               5               


<210>  842
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  842

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  843
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  843

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  844
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  844

Ala Arg Asp Asn Pro Asp Phe Asp Tyr 
1               5                   


<210>  845
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  845

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  846
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  846

Ala Ala Ser 
1           


<210>  847
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  847

Gln Gln Ser Tyr Arg Thr Pro Ile Thr 
1               5                   


<210>  848
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  848

Gly Gly Thr Phe Ser Ser Asn Ala 
1               5               


<210>  849
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  849

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  850
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  850

Ala Gly Ser Pro Thr Gly Thr Pro Arg Val Val Phe Asp Tyr 
1               5                   10                  


<210>  851
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  851

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  852
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  852

Ala Ala Ser 
1           


<210>  853
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  853

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  854
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  854

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  855
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  855

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  856
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  856

Ala Arg Asp Thr Ser Ile Ala Ala Arg Leu Asn Pro Asp Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val 
            20          


<210>  857
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  857

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  858
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  858

Ala Ala Ser 
1           


<210>  859
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  859

Gln Gln Ser Tyr Ser Thr Pro Val Thr 
1               5                   


<210>  860
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  860

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  861
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  861

Ile Ile Pro Val Val Gly Ser Pro 
1               5               


<210>  862
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  862

Ala Arg His Ser Ile Val Gly Ala Thr Ala Thr Ser Met Asp Val 
1               5                   10                  15  


<210>  863
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  863

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  864
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  864

Leu Gly Ser 
1           


<210>  865
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  865

Met Gln Ala Thr His Trp Pro Leu Thr 
1               5                   


<210>  866
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  866

Gly Tyr Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  867
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  867

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  868
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  868

Ala Arg Gly Ser Leu Asp Ile Trp Phe Arg Glu Pro Gly Val Tyr Met 
1               5                   10                  15      


Asp Val 
        


<210>  869
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  869

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  870
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  870

Ala Ala Ser 
1           


<210>  871
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  871

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  872
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  872

Gly Tyr Ala Phe Thr Asp Tyr Phe 
1               5               


<210>  873
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  873

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  874
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  874

Ala Arg Val Ala Tyr Gly Ala Phe Asp Ile 
1               5                   10  


<210>  875
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  875

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  876
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  876

Gly Ala Ser 
1           


<210>  877
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  877

Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  878
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  878

Gly Gly Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  879
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  879

Ile Asn Pro Ser Arg Gly Thr Thr 
1               5               


<210>  880
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  880

Ala Lys Gly Asp Ile Val Val Val Pro Ala Ala Met Phe Ser Leu Gly 
1               5                   10                  15      


Pro Gly Tyr Tyr Tyr Tyr Met Asp Val 
            20                  25  


<210>  881
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  881

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  882
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  882

Ala Ala Ser 
1           


<210>  883
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  883

Gln Gln Ala Asn Ser Phe Pro Ile Thr 
1               5                   


<210>  884
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  884

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  885
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  885

Ile Trp Ser Asp Gly Gly His Lys 
1               5               


<210>  886
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  886

Ala Arg Glu Val Arg Gly Trp Phe Asp Pro 
1               5                   10  


<210>  887
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  887

Glu Asn Ile Gly Thr Trp 
1               5       


<210>  888
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  888

Lys Ala Ser 
1           


<210>  889
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  889

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  890
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  890

Gly Phe Ala Phe Ser Ser His Trp 
1               5               


<210>  891
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  891

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  892
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  892

Ala Arg Asp Arg Gly Met Ile Asp Tyr 
1               5                   


<210>  893
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  893

Gln Gly Ile Gly Ser Trp 
1               5       


<210>  894
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  894

Ala Ala Thr 
1           


<210>  895
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  895

Gln Gln Ser Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  896
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  896

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  897
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  897

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  898
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  898

Ala Arg Asp Gln Gly Trp Phe Asp Pro 
1               5                   


<210>  899
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  899

Arg Ala Ile Gly Asn Asn 
1               5       


<210>  900
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  900

Thr Ala Ser 
1           


<210>  901
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  901

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  902
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  902

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  903
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  903

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  904
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  904

Ala Arg Asp Ile Ala Gly Tyr Phe Asp Leu 
1               5                   10  


<210>  905
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  905

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  906
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  906

Ala Ala Ser 
1           


<210>  907
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  907

Gln Gln Gly Tyr Leu Thr Pro Tyr Thr 
1               5                   


<210>  908
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  908

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  909
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  909

Ile Ile Pro Val Leu Gly Ala Ala 
1               5               


<210>  910
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  910

Ala Lys Gly Trp Gly Ala Phe Asp Ile 
1               5                   


<210>  911
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  911

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  912
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  912

Gly Ala Ser 
1           


<210>  913
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  913

Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  914
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  914

Gly Tyr Thr Phe Ser Asp His Tyr 
1               5               


<210>  915
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  915

Ile Ile Pro Ile Leu Gly Thr Ala 
1               5               


<210>  916
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  916

Ala Thr Asp Ile Ala Val Ala Gly Thr Gly Phe Asp Tyr 
1               5                   10              


<210>  917
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  917

Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  918
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  918

Trp Ala Ser 
1           


<210>  919
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  919

Gln Gln Tyr Tyr Gly Thr Pro Leu Thr 
1               5                   


<210>  920
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  920

Asp Phe Asn Phe Lys Asn Ala Trp 
1               5               


<210>  921
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  921

Ile Ser Gly Asn Gly Ala Gly Thr 
1               5               


<210>  922
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  922

Ala Arg Val Gly Glu Thr Gly Ala Phe Asp Ile 
1               5                   10      


<210>  923
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  923

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  924
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  924

Asp Ala Ser 
1           


<210>  925
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  925

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  926
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  926

Gly Gly Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  927
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  927

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  928
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  928

Ala Lys Gly Asp Tyr Gly Glu Thr Gly Val Asp Phe Asp Tyr 
1               5                   10                  


<210>  929
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  929

Gln Asp Ile His Asn Tyr 
1               5       


<210>  930
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  930

Thr Ala Ser 
1           


<210>  931
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  931

Gln Gln Ser Tyr Asn Ile Pro Ile Thr 
1               5                   


<210>  932
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  932

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  933
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  933

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  934
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  934

Ala Arg Val Met Val Ala Gly Thr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  935
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  935

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  936
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  936

Gly Ala Ser 
1           


<210>  937
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  937

Met Gln Gly Leu His Thr Pro Pro Thr 
1               5                   


<210>  938
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  938

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  939
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  939

Ile Ser Ser Ser Gly Asn Tyr Met 
1               5               


<210>  940
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  940

Ala Thr Glu Thr Tyr Ser Tyr Ser Ser Met Asp Val 
1               5                   10          


<210>  941
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  941

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  942
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  942

Asp Ala Ser 
1           


<210>  943
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  943

Gln Gln Ser Tyr Gly Thr Pro Leu Thr 
1               5                   


<210>  944
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  944

Gly Tyr Thr Phe Thr Glu Asn Glu 
1               5               


<210>  945
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  945

Ile Ser Ala Tyr Asn Gly Asp Thr 
1               5               


<210>  946
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  946

Ala Lys Glu Val Arg Leu Asp Asp Asp Glu Met Trp Tyr Phe Asp Leu 
1               5                   10                  15      


<210>  947
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  947

Gln Asp Ile Asn Asn Phe 
1               5       


<210>  948
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  948

Asp Ala Ser 
1           


<210>  949
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  949

Gln Gln Ala Tyr Ser Phe Pro Leu Thr 
1               5                   


<210>  950
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  950

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  951
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  951

Ile Gly Thr Ala Gly Asp Thr 
1               5           


<210>  952
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  952

Ala Ile Leu Arg Arg Asp Lys Val Trp Pro Phe Asp Tyr 
1               5                   10              


<210>  953
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  953

Gln Ser Ile Ser Ser His 
1               5       


<210>  954
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  954

Ala Ala Ser 
1           


<210>  955
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  955

Gln Gln Ser Tyr Ser Ser Pro Val Thr 
1               5                   


<210>  956
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  956

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  957
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  957

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  958
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  958

Ala Arg Ala Ala Ala Ala Gly Thr Ala Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  959
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  959

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  960
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  960

Leu Gly Ser 
1           


<210>  961
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  961

Met Gln Gly Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  962
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  962

Gly Phe Ser Phe Ser Thr Tyr Trp 
1               5               


<210>  963
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  963

Ile Ser Gly Gly Gly Ile Tyr Thr 
1               5               


<210>  964
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  964

Ala Ser Met Thr Tyr Gly Asp Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  965
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  965

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  966
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  966

Ala Ala Ser 
1           


<210>  967
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  967

Gln Gln Thr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  968
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  968

Gly Gly Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  969
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  969

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  970
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  970

Ala Lys Asp Leu Gly Gly Trp Phe Asn Leu Phe Asp Pro 
1               5                   10              


<210>  971
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  971

Gln Gly Val Ser Ser Tyr 
1               5       


<210>  972
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  972

Gly Ala Ser 
1           


<210>  973
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  973

Gln Gln Tyr Arg Ser Phe Pro Leu Thr 
1               5                   


<210>  974
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  974

Gly Tyr Thr Phe Ala Gly Gln Tyr 
1               5               


<210>  975
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  975

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  976
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  976

Ala Arg Gly Asp Tyr Ser Glu Thr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  977
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  977

Gln His Ile Asn Ser Asn 
1               5       


<210>  978
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  978

Gly Ala Ser 
1           


<210>  979
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  979

Gln Gln Ser Tyr Thr Thr Pro Phe Thr 
1               5                   


<210>  980
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  980

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  981
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  981

Ile Ser Ser Ser Gly Gly Tyr Leu 
1               5               


<210>  982
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  982

Ala Arg Asp Trp Gly Leu Thr Pro Asp Tyr 
1               5                   10  


<210>  983
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  983

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  984
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  984

Asp Ala Ser 
1           


<210>  985
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  985

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  986
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  986

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  987
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  987

Ile Ser Gly Thr Ala Ile Asn Thr 
1               5               


<210>  988
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  988

Ala Arg Val Arg Arg Asp Ser Ser Gly Gly Gly Ala Phe Asp Ile 
1               5                   10                  15  


<210>  989
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  989

Gln Gly Ile Ser Asn Asn 
1               5       


<210>  990
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  990

Ala Ala Ser 
1           


<210>  991
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  991

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  992
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  992

Gly Tyr Thr Phe Ser Asp Phe Ser 
1               5               


<210>  993
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  993

Met Leu Pro Ile Ser His Ile Ala 
1               5               


<210>  994
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  994

Ala Arg Gly Gly Ser Ser Gly Trp Phe Glu Val 
1               5                   10      


<210>  995
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  995

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  996
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  996

Ala Ala Ser 
1           


<210>  997
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  997

Met Gln Gly Ala His Trp Pro Pro Thr 
1               5                   


<210>  998
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  998

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  999
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  999

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1000
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1000

Ala Arg Gly Leu Gly Trp Phe Asp Pro 
1               5                   


<210>  1001
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1001

Gln His Ile Gly Asn Ser 
1               5       


<210>  1002
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1002

Ala Ala Ser 
1           


<210>  1003
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1003

Gln Gln Ser Tyr Gly Thr Pro Leu Thr 
1               5                   


<210>  1004
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1004

Gly Gly Ser Phe Ser Gly Gln Ala 
1               5               


<210>  1005
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1005

Phe Val Ser Leu Phe Gly Thr Ala 
1               5               


<210>  1006
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1006

Ala Arg Asp Arg Glu Gly Leu Gly Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  1007
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1007

Gln Ser Val Leu Tyr Ser Ser Ser Asn Glu Asn Tyr 
1               5                   10          


<210>  1008
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1008

Trp Ala Ser 
1           


<210>  1009
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1009

Gln Gln Tyr Tyr Ser Ile Pro Tyr Thr 
1               5                   


<210>  1010
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1010

Gly Gly Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  1011
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1011

Ile Ile Pro Ser Phe Asn Ala Pro 
1               5               


<210>  1012
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1012

Ala Arg Val Val Pro Ala Ala Ile Val Gly Trp Tyr Phe Asp Leu 
1               5                   10                  15  


<210>  1013
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1013

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  1014
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1014

Ala Ala Ser 
1           


<210>  1015
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1015

Met Gln Ala Leu Gln Thr Pro Pro Thr 
1               5                   


<210>  1016
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1016

Gly Gly Ile Leu Asn Ser Tyr Ala 
1               5               


<210>  1017
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1017

Ile Ile Pro Ile Leu Gly Ile Ala 
1               5               


<210>  1018
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1018

Val Glu Asn Glu Ser Gly Pro Leu Phe Asp Tyr 
1               5                   10      


<210>  1019
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1019

Gln Ser Val Tyr Ser Ser Tyr 
1               5           


<210>  1020
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1020

Gly Thr Ser 
1           


<210>  1021
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1021

Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  1022
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1022

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  1023
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1023

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  1024
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1024

Ala Arg Val Met Ala Arg Arg Asp Gly Tyr Asn Phe Lys Gly Gly Trp 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  1025
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1025

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  1026
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1026

Ala Ala Ser 
1           


<210>  1027
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1027

Met Gln Ala Leu Glu Thr Pro Pro Thr 
1               5                   


<210>  1028
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1028

Gly Phe Ser Phe Ser Thr Tyr Gly 
1               5               


<210>  1029
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1029

Phe Val Pro Ile Ile Gly Ser Ala 
1               5               


<210>  1030
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1030

Ala Arg Asp Tyr Gly Gly Asn Leu Asp Tyr 
1               5                   10  


<210>  1031
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1031

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  1032
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1032

Ala Ala Ser 
1           


<210>  1033
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1033

Met Gln Gly Ala His Trp Pro Pro Thr 
1               5                   


<210>  1034
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1034

Gly Gly Ser Phe Ser Ser Trp Ala 
1               5               


<210>  1035
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1035

Ile Ile Pro Leu Phe Gly Thr Val 
1               5               


<210>  1036
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1036

Ala Arg Asp Leu Pro Asp Met Val Ser 
1               5                   


<210>  1037
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1037

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1038
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1038

Ala Ala Ser 
1           


<210>  1039
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1039

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  1040
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1040

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  1041
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1041

Ile Ser Gly Thr Ala Ile Asn Thr 
1               5               


<210>  1042
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1042

Ala Arg Val Arg Arg Asp Ser Ser Gly Gly Gly Ala Phe Asp Ile 
1               5                   10                  15  


<210>  1043
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1043

Gln Gly Ile Ser Asn Asn 
1               5       


<210>  1044
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1044

Ala Ala Ser 
1           


<210>  1045
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1045

Gln Gln Ser Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  1046
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1046

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  1047
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1047

Ile Ser Gly Phe Gly Glu Ser Thr 
1               5               


<210>  1048
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1048

Ala Arg Leu Gly Ala Ala Arg Ala Phe Asp Ile 
1               5                   10      


<210>  1049
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1049

Gln Ser Ile Gly Ser Trp 
1               5       


<210>  1050
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1050

Ala Ala Ser 
1           


<210>  1051
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1051

Gln Gln Ser Tyr Thr Thr Pro Ile Thr 
1               5                   


<210>  1052
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1052

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  1053
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1053

Ile Ser Gly Ser Gly Ser Tyr Ile 
1               5               


<210>  1054
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1054

Ala Arg Arg Gly Ser Ser Trp Ser Asn Phe Asp Tyr 
1               5                   10          


<210>  1055
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1055

Gln Thr Ile Ser Thr Tyr 
1               5       


<210>  1056
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1056

Asp Ala Ser 
1           


<210>  1057
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1057

Gln Gln Ser Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  1058
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1058

Gly Tyr Thr Phe Ser Thr Tyr Asp 
1               5               


<210>  1059
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1059

Ile Ser Pro Ser Gly Gly Trp Thr 
1               5               


<210>  1060
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1060

Ala Arg Val Asn Tyr Asp Ile Leu Thr Gly Gln Gly Arg Gly Tyr Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  1061
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1061

Gln Asp Ile Ala Asp Tyr 
1               5       


<210>  1062
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1062

Lys Ala Ser 
1           


<210>  1063
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1063

Gln Gln Ser Tyr Ser Thr Pro Thr 
1               5               


<210>  1064
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1064

Gly Tyr Ile Phe Thr Arg Tyr Tyr 
1               5               


<210>  1065
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1065

Ile Ile Pro Met Phe Gly Thr Ser 
1               5               


<210>  1066
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1066

Ala Arg Ser Ser Gly Tyr Asp Ser Phe Lys Ile Asp Tyr 
1               5                   10              


<210>  1067
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1067

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  1068
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1068

Leu Gly Ser 
1           


<210>  1069
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1069

Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210>  1070
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1070

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  1071
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1071

Met Asn Pro Asn Ser Gly Asn Thr 
1               5               


<210>  1072
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1072

Ala Arg Glu Thr Ser Phe Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  1073
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1073

Gln Ser Ile Ser Asn Trp 
1               5       


<210>  1074
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1074

Asp Gly Ser 
1           


<210>  1075
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1075

Leu Gln Asp Phe Thr Tyr Pro Leu Thr 
1               5                   


<210>  1076
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1076

Gly Tyr Thr Phe Thr Asn Tyr Ala 
1               5               


<210>  1077
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1077

Ile Ile Pro Val Phe Gly Thr Ala 
1               5               


<210>  1078
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1078

Ala Arg Val Ser Thr Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ala Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  1079
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1079

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1080
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1080

Asp Ala Ser 
1           


<210>  1081
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1081

Gln Gln Thr Tyr His Thr Pro Trp Thr 
1               5                   


<210>  1082
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1082

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1083
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1083

Met Ser Tyr Asp Gly Arg His Glu 
1               5               


<210>  1084
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1084

Ala Ser Thr Asp Tyr Asp Ile Gly Gly Tyr Ser Leu Pro Leu Asp Tyr 
1               5                   10                  15      


<210>  1085
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1085

Gln Ser Val Ser Ser Trp 
1               5       


<210>  1086
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1086

Ala Ala Ser 
1           


<210>  1087
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1087

Gln Gln Ser Tyr Asp Val Pro Trp Thr 
1               5                   


<210>  1088
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1088

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  1089
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1089

Ile Ile Pro Ile Tyr Gly Thr Ala 
1               5               


<210>  1090
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1090

Ala Arg Thr Asn Trp Gly Met Asp Val 
1               5                   


<210>  1091
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1091

Gln Gly Ile Pro Ser Asn Ser 
1               5           


<210>  1092
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1092

Gly Thr Ser 
1           


<210>  1093
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1093

Gln Gln Tyr Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  1094
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1094

Gly Gly Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  1095
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1095

Ile Tyr Pro Ser Gly Asp Ile Thr 
1               5               


<210>  1096
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1096

Ala Arg Ala Trp Ala Arg Tyr Phe Asp Tyr 
1               5                   10  


<210>  1097
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1097

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  1098
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1098

Asp Ala Ser 
1           


<210>  1099
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1099

Gln Gln Ser Tyr Ser Ser Pro Ile Thr 
1               5                   


<210>  1100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1100

Gly Asn Thr Phe Thr Ala Tyr Tyr 
1               5               


<210>  1101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1101

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  1102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1102

Ala Arg Gly Val Gly Ala Thr Asn Tyr 
1               5                   


<210>  1103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1103

Gln Gly Ile Ser Asn Asn 
1               5       


<210>  1104
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1104

Ala Ala Ser 
1           


<210>  1105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1105

Gln Gln Gly Phe Asn Phe Pro Leu Thr 
1               5                   


<210>  1106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1106

Gly Tyr Arg Phe Thr Asp Tyr Tyr 
1               5               


<210>  1107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1107

Ile Gln Pro Thr Gly Gly Gly Thr 
1               5               


<210>  1108
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1108

Ala Arg Val Gly Ala Thr Val Thr Lys Asn Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  1109
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1109

Gln Ser Val Leu Tyr Ser Ser Asn Asn Arg Asn Tyr 
1               5                   10          


<210>  1110
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1110

Trp Ala Ser 
1           


<210>  1111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1111

Gln Gln Tyr Tyr Ser Val Pro Leu Thr 
1               5                   


