                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  HUMAN ANTIBODIES TARGETING ZIKA VIRUS NS1, NS1 POLYPEPTIDES AND 
       USES THEREOF

<130>  6923-292-228

<140>  PCT/US2019/058865
<141>  2019-10-30

<150>  US 62/753,727
<151>  2018-10-31

<160>  168

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region mRNA, 
       partial CDS

<400>  1
gaggtgcagc tggtggagtc cggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatcgaagg      300

gggtttgact actggggcca gggaacaatg gtcaccgtct cttca                      345


<210>  2
<211>  321
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region mRNA, 
       partial CDS

<400>  2
gacatccaga tgacccagtc tccactctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc ggacaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctta ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag acttacagta cccctctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321


<210>  3
<211>  357
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region mRNA, 
       partial CDS

<400>  3
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag atggggaggg      300

aaacgggggg gggcttttga tatctggggc caagggacaa tggtcaccgt ctcttca         357


<210>  4
<211>  322
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region mRNA, 
       partial CDS

<400>  4
gacatccaga tgacccagtc tccattctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agccatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagttcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagac ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ctccgtacac ttttggccag      300

gggaccaagg tggaaatcaa ac                                               322


<210>  5
<211>  349
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region mRNA, 
       partial CDS

<400>  5
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgagca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag actcatagca      300

gcagctggtg actactgggg ccagggaaca atggtcaccg tctcttcag                  349


<210>  6
<211>  322
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region mRNA, 
       partial CDS

<400>  6
gacatccaga tgacccagtc tccattcacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtgaatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccctggac gttcggccaa      300

gggaccaagg tggagatcaa ac                                               322


<210>  7
<211>  369
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region mRNA, 
       partial CDS

<400>  7
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccagact      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agggcccgta      300

caactggaac gacggcctct gggtgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210>  8
<211>  319
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region mRNA, 
       partial CDS

<400>  8
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataaatt gggggataaa tatgcttgct ggtatcagca gaagccaggc      120

cagtcccctg tgctggtcat ctatcaagat agcaagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca ccgtggtatt cggcggaggg      300

accaagctga ccgtcctag                                                   319


<210>  9
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region amino 
       acid sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  10
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region amino 
       acid sequence

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  119
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region amino acid
       sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Gly Gly Lys Arg Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region amino acid
       sequence

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  116
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region amino acid
       sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Ile Ala Ala Ala Gly Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  14
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region amino acid
       sequence

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Phe Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  123
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region amino 
       acid sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Val Gln Leu Glu Arg Arg Pro Leu Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region amino 
       acid sequence

<400>  16

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region CDR1 
       amino acid sequence (IMGT)

<400>  17

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region CDR2 
       amino acid sequence (IMGT)

<400>  18

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region CDR3 
       amino acid sequence (IMGT)

<400>  19

Ala Arg Asp Arg Arg Gly Phe Asp Tyr 
1               5                   


<210>  20
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region CDR1 
       amino acid sequence (IMGT)

<400>  20

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  21
<211>  3
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region CDR2 
       amino acid sequence (IMGT)

<400>  21

Ala Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region CDR3 
       amino acid sequence (IMGT)

<400>  22

Gln Gln Thr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  23
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 1 amino acid sequence (IMGT)

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 2 amino acid sequence (IMGT)

<400>  24

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Val 
    


<210>  25
<211>  38
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 3 amino acid sequence (IMGT)

<400>  25

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 4 amino acid sequence (IMGT)

<400>  26

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  27
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 1 amino acid sequence (IMGT)

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser 
            20                  25      


<210>  28
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 2 amino acid sequence (IMGT)

<400>  28

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  29
<211>  36
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 3 amino acid sequence (IMGT)

<400>  29

Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 4 amino acid sequence (IMGT)

<400>  30

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region ABR1 
       amino acid sequence (Paratome)

<400>  31

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  32
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region ABR2 
       amino acid sequence (Paratome)

<400>  32

Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10                  


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region ABR3 
       amino acid sequence (Paratome)

<400>  33

Ala Arg Asp Arg Arg Gly Phe Asp Tyr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region ABR1 
       amino acid sequence (Paratome)

<400>  34

Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region ABR2 
       amino acid sequence (Paratome)

<400>  35

Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region ABR3 
       amino acid sequence (Paratome)

<400>  36

Gln Gln Thr Tyr Ser Thr Pro Leu 
1               5               


<210>  37
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 1 amino acid sequence (Paratome)

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ISOLATE AA12 immunoglobulin heavy chain variable region framework
       region 2 amino acid sequence (Paratome)

<400>  38

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
1               5                   10      


<210>  39
<211>  35
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 3 amino acid sequence (Paratome)

<400>  39

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
1               5                   10                  15      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin heavy chain variable region framework
       region 4 amino acid sequence (Paratome)

<400>  40

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  41
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 1 amino acid sequence (Paratome)

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser 
            20                  25      


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 2 amino acid sequence (Paratome)

<400>  42

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
1               5                   10      


<210>  43
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 3 amino acid sequence (Paratome)

<400>  43

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  44
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate AA12 immunoglobulin light chain variable region framework
       region 4 amino acid sequence (Paratome)

<400>  44

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region CDR1 amino
       acid sequence (IMGT)

<400>  45

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region CDR2 amino
       acid sequence (IMGT)

<400>  46

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region CDR3 amino
       acid sequence (IMGT)

<400>  47

Ala Arg Trp Gly Gly Lys Arg Gly Gly Ala Phe Asp Ile 
1               5                   10              


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region CDR1 amino
       acid sequence (IMGT)

<400>  48

Gln Ser Ile Ser Ser His 
1               5       


<210>  49
<211>  3
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region CDR2 amino
       acid sequence (IMGT)

<400>  49

Ala Ala Ser 
1           


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region CDR3 amino
       acid sequence (IMGT)

<400>  50

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  51
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 1 amino acid sequence (IMGT)

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  52
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 2 amino acid sequence (IMGT)

<400>  52

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Val 
    


<210>  53
<211>  38
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 3 amino acid sequence (IMGT)

<400>  53

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  54
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 4 amino acid sequence (IMGT)

<400>  54

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  55
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 1 amino acid sequence (IMGT)

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  56
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 2 amino acid sequence (IMGT)

<400>  56

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  57
<211>  36
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 3 amino acid sequence (IMGT)

<400>  57

Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  58
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 4 amino acid sequence (IMGT)

<400>  58

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  59
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region ABR1 amino
       acid sequence (Paratome)

<400>  59

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  60
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region ABR2 amino
       acid sequence (Paratome)

<400>  60

Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10                  


<210>  61
<211>  13
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region ABR3 amino
       acid sequence (Paratome)

<400>  61

Ala Arg Trp Gly Gly Lys Arg Gly Gly Ala Phe Asp Ile 
1               5                   10              


<210>  62
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region ABR1 amino
       acid sequence (Paratome)

<400>  62

Gln Ser Ile Ser Ser His Leu Asn 
1               5               


<210>  63
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region ABR2 amino
       acid sequence (Paratome)

<400>  63

Phe Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210>  64
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region ABR3 amino
       acid sequence (Paratome)

<400>  64

Gln Gln Ser Tyr Ser Thr Pro Tyr 
1               5               


<210>  65
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 1 amino acid sequence (Paratome)

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  66
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 2 amino acid sequence (Paratome)

<400>  66

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
1               5                   10      


<210>  67
<211>  35
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 3 amino acid sequence (Paratome)

<400>  67

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
1               5                   10                  15      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  68
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin heavy chain variable region framework 
       region 4 amino acid sequence (Paratome)

<400>  68

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 1 amino acid sequence (Paratome)

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  70
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 2 amino acid sequence (Paratome)

<400>  70

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
1               5                   10      


<210>  71
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 3 amino acid sequence (Paratome)

<400>  71

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate EB9 immunoglobulin light chain variable region framework 
       region 4 amino acid sequence (Paratome)

<400>  72

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  73
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region CDR1 amino
       acid sequence (IMGT)

<400>  73

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  74
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region CDR2 amino
       acid sequence (IMGT)

<400>  74

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  75
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region CDR3 amino
       acid sequence (IMGT)

<400>  75

Ala Arg Leu Ile Ala Ala Ala Gly Asp Tyr 
1               5                   10  


<210>  76
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region CDR1 amino
       acid sequence (IMGT)

<400>  76

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  77
<211>  3
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region CDR2 amino
       acid sequence (IMGT)

<400>  77

Ala Ala Ser 
1           


<210>  78
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region CDR3 amino
       acid sequence (IMGT)

<400>  78

Gln Gln Ser Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  79
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 1 amino acid sequence (IMGT)

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  80
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 2 amino acid sequence (IMGT)

<400>  80

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Val 
    


<210>  81
<211>  38
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 3 amino acid sequence (IMGT)

<400>  81

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  82
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 4 amino acid sequence (IMGT)

<400>  82

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  83
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 1 amino acid sequence (IMGT)

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Phe Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  84
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 2 amino acid sequence (IMGT)

<400>  84

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  85
<211>  36
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 3 amino acid sequence (IMGT)

<400>  85

Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  86
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 4 amino acid sequence (IMGT)

<400>  86

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  87
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region ABR1 amino
       acid sequence (Paratome)

<400>  87

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  88
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region ABR2 amino
       acid sequence (Paratome)

<400>  88

Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10                  


<210>  89
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region ABR3 amino
       acid sequence (Paratome)

<400>  89

Ala Arg Leu Ile Ala Ala Ala Gly Asp Tyr 
1               5                   10  


<210>  90
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region ABR1 amino
       acid sequence (Paratome)

<400>  90

Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5               


<210>  91
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region ABR2 amino
       acid sequence (Paratome)

<400>  91

Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210>  92
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region ABR3 amino
       acid sequence (Paratome)

<400>  92

Gln Gln Ser Tyr Ser Thr Pro Trp 
1               5               


<210>  93
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 1 amino acid sequence (Paratome)

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  94
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 2 amino acid sequence (Paratome)

<400>  94

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
1               5                   10      


<210>  95
<211>  35
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 3 amino acid sequence (Paratome)

<400>  95

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
1               5                   10                  15      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  96
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin heavy chain variable region framework 
       region 4 amino acid sequence (Paratome)

<400>  96

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  97
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 1 amino acid sequence (Paratome)

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Phe Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  98
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 2 amino acid sequence (Paratome)

<400>  98

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
1               5                   10      


<210>  99
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 3 amino acid sequence (Paratome)

<400>  99

Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  100
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate GB5 immunoglobulin light chain variable region framework 
       region 4 amino acid sequence (Paratome)

<400>  100

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10      


<210>  101
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region CDR1 
       amino acid sequence (IMGT)

<400>  101

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  102
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region CDR2 
       amino acid sequence (IMGT)

<400>  102

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  103
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region CDR3 
       amino acid sequence (IMGT)

<400>  103

Ala Arg Gly Pro Val Gln Leu Glu Arg Arg Pro Leu Gly Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  104
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region CDR1 
       amino acid sequence (IMGT)

<400>  104

Lys Leu Gly Asp Lys Tyr 
1               5       


<210>  105
<211>  3
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region CDR2 
       amino acid sequence (IMGT)

<400>  105

Gln Asp Ser 
1           


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region CDR3 
       amino acid sequence (IMGT)

<400>  106

Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   


<210>  107
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 1 amino acid sequence (IMGT)

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  108
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 2 amino acid sequence (IMGT)

<400>  108

Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Val 
    


<210>  109
<211>  38
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 3 amino acid sequence (IMGT)

<400>  109

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  110
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 4 amino acid sequence (IMGT)

<400>  110

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  111
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 1 amino acid sequence (IMGT)

<400>  111

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp 
            20                  25  


<210>  112
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 2 amino acid sequence (IMGT)

<400>  112

Ala Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile 
1               5                   10                  15      


Tyr 
    


<210>  113
<211>  36
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 3 amino acid sequence (IMGT)

<400>  113

Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
1               5                   10                  15      


Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  114
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 4 amino acid sequence (IMGT)

<400>  114

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  115
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region ABR1 
       amino acid sequence (Paratome)

<400>  115

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  116
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region ABR2 
       amino acid sequence (Paratome)

<400>  116

Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10                  


<210>  117
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region ABR3 
       amino acid sequence (Paratome)

<400>  117

Ala Arg Gly Pro Val Gln Leu Glu Arg Arg Pro Leu Gly Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  118
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region ABR1 
       amino acid sequence (Paratome)

<400>  118

Lys Leu Gly Asp Lys Tyr Ala Cys 
1               5               


<210>  119
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region ABR2 
       amino acid sequence (Paratome)

<400>  119

Leu Val Ile Tyr Gln Asp Ser Lys Arg Pro Ser 
1               5                   10      


<210>  120
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region ABR3 
       amino acid sequence (Paratome)

<400>  120

Gln Ala Trp Asp Ser Ser Thr Val 
1               5               


<210>  121
<211>  26
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 1 amino acid sequence (Paratome)

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  122
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 2 amino acid sequence (Paratome)

<400>  122

Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
1               5                   10      


<210>  123
<211>  35
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 3 amino acid sequence (Paratome)

<400>  123

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
1               5                   10                  15      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  124
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin heavy chain variable region framework
       region 4 amino acid sequence (Paratome)

<400>  124

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  125
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 1 amino acid sequence (Paratome)

<400>  125

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp 
            20                  25  


<210>  126
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 2 amino acid sequence (Paratome)

<400>  126

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val 
1               5                   10      


<210>  127
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 3 amino acid sequence (Paratome)

<400>  127

Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  128
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Isolate FC12 immunoglobulin light chain variable region framework
       region 4 amino acid sequence (Paratome)

<400>  128

Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10      


<210>  129
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The NS1 nucleotide sequence of MR766 virus (Rhesus/1947/Uganda)

<400>  129
gacgtggggt gctcagtgga cttctcaaaa aaggaaacga gatgtggcac gggggtattc       60

atctataatg atgttgaagc ctggagggac cggtacaagt accatcctga ctccccccgc      120

agattggcag cagcagtcaa gcaggcctgg gaagagggga tctgtgggat ctcatccgtt      180

tcaagaatgg aaaacatcat gtggaaatca gtagaagggg agctcaatgc tatcctagag      240

gagaatggag ttcaactgac agttgttgtg ggatctgtaa aaaaccccat gtggagaggt      300

ccacaaagat tgccagtgcc tgtgaatgag ctgccccatg gctggaaagc ctgggggaaa      360

tcgtattttg ttagggcggc aaagaccaac aacagttttg ttgtcgacgg tgacacactg      420

aaggaatgtc cgcttgagca cagagcatgg aatagttttc ttgtggagga tcacgggttt      480

ggagtcttcc acaccagtgt ctggcttaag gtcagagaag attactcatt agaatgtgac      540

ccagccgtca taggaacagc tgttaaggga agggaggccg cgcacagtga tctgggctat      600

tggattgaaa gtgaaaagaa tgacacatgg aggctgaaga gggcccacct gattgagatg      660

aaaacatgtg aatggccaaa gtctcacaca ttgtggacag atggagtaga agaaagtgat      720

cttatcatac ccaagtcttt agctggtcca ctcagccacc acaacaccag agagggttac      780

agaacccaag tgaaagggcc atggcacagt gaagagcttg aaatccggtt tgaggaatgt      840

ccaggcacca aggtttacgt ggaggagaca tgcggaacta gaggaccatc tctgagatca      900

actactgcaa gtggaagggt cattgaggaa tggtgctgta gggaatgcac aatgccccca      960

ctatcgtttc gagcaaaaga cggctgctgg tatggaatgg agataaggcc caggaaagaa     1020

ccagagagca acttagtgag gtcaatggtg acagcg                               1056


<210>  130
<211>  10675
<212>  DNA
<213>  Zika Virus

<220>
<223>  PRVABC59 virus (2015/Puerto Rico Accession: No.: KU501215)

<400>  130
gttgttgatc tgtgtgaatc agactgcgac agttcgagtt tgaagcgaaa gctagcaaca       60

gtatcaacag gttttatttt ggatttggaa acgagagttt ctggtcatga aaaacccaaa      120

aaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtgag      180

cccctttggg ggcttgaaga ggctgccagc cggacttctg ctgggtcatg ggcccatcag      240

gatggtcttg gcgattctag cctttttgag attcacggca atcaagccat cactgggtct      300

catcaataga tggggttcag tggggaaaaa agaggctatg gaaacaataa agaagttcaa      360

gaaagatctg gctgccatgc tgagaataat caatgctagg aaggagaaga agagacgagg      420

cgcagatact agtgtcggaa ttgttggcct cctgctgacc acagctatgg cagcggaggt      480

cactagacgt gggagtgcat actatatgta cttggacaga aacgatgctg gggaggccat      540

atcttttcca accacattgg ggatgaataa gtgttatata cagatcatgg atcttggaca      600

catgtgtgat gccaccatga gctatgaatg ccctatgctg gatgaggggg tggaaccaga      660

tgacgtcgat tgttggtgca acacgacgtc aacttgggtt gtgtacggaa cctgccatca      720

caaaaaaggt gaagcacgga gatctagaag agctgtgacg ctcccctccc attccaccag      780

gaagctgcaa acgcggtcgc aaacctggtt ggaatcaaga gaatacacaa agcacttgat      840

tagagtcgaa aattggatat tcaggaaccc tggcttcgcg ttagcagcag ctgccatcgc      900

ttggcttttg ggaagctcaa cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagcatca ggtgcatagg agtcagcaat agggactttg tggaaggtat     1020

gtcaggtggg acttgggttg atgttgtctt ggaacatgga ggttgtgtca ccgtaatggc     1080

acaggacaaa ccgactgtcg acatagagct ggttacaaca acagtcagca acatggcgga     1140

ggtaagatcc tactgctatg aggcatcaat atcagacatg gcttctgaca gccgctgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

gttagtggac agaggctggg gaaatggatg tggacttttt ggcaaaggga gcctggtgac     1320

atgcgctaag tttgcatgct ccaagaaaat gaccgggaag agcatccagc cagagaatct     1380

ggagtaccgg ataatgctgt cagttcatgg ctcccagcac agtgggatga tcgttaatga     1440

cacaggacat gaaactgatg agaatagagc gaaagttgag ataacgccca attcaccgag     1500

agccgaagcc accctggggg gttttggaag cctaggactt gattgtgaac cgaggacagg     1560

ccttgacttt tcagatttgt attacttgac tatgaataac aagcactggt tggttcacaa     1620

ggagtggttc cacgacattc cattaccttg gcacgctggg gcagacaccg gaactccaca     1680

ctggaacaac aaagaagcac tggtagagtt caaggacgca catgccaaaa ggcaaactgt     1740

cgtggttcta gggagtcaag aaggagcagt tcacacggcc cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaagg gaaggctgtc ctctggccac ttgaaatgtc gcctgaaaat     1860

ggataaactt agattgaagg gcgtgtcata ctccttgtgt actgcagcgt tcacattcac     1920

caagatcccg gctgaaacac tgcacgggac agtcacagtg gaggtacagt acgcagggac     1980

agatggacct tgcaaggttc cagctcagat ggcggtggac atgcaaactc tgaccccagt     2040

tgggaggttg ataaccgcta accccgtaat cactgaaagc actgagaact ctaagatgat     2100

gctggaactt gatccaccat ttggggactc ttacattgtc ataggagtcg gggagaagaa     2160

gatcacccac cactggcaca ggagtggcag caccattgga aaagcatttg aagccactgt     2220

gagaggtgcc aagagaatgg cagtcttggg agacacagcc tgggactttg gatcagttgg     2280

aggcgctctc aactcattgg gcaagggcat ccatcaaatt tttggagcag ctttcaaatc     2340

attgtttgga ggaatgtcct ggttctcaca aattctcatt ggaacgttgc tgatgtggtt     2400

gggtctgaac acaaagaatg gatctatttc ccttatgtgc ttggccttag ggggagtgtt     2460

gatcttctta tccacagccg tctctgctga tgtggggtgc tcggtggact tctcaaagaa     2520

ggagacgaga tgcggtacag gggtgttcgt ctataacgac gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgtag attggcagca gcagtcaagc aagcctggga     2640

agatggtatc tgcgggatct cctctgtttc aagaatggaa aacatcatgt ggagatcagt     2700

agaaggggag ctcaacgcaa tcctggaaga gaatggagtt caactgacgg tcgttgtggg     2760

atctgtaaaa aaccccatgt ggagaggtcc acagagattg cccgtgcctg tgaacgagct     2820

gccccacggc tggaaggctt gggggaaatc gtatttcgtc agagcagcaa agacaaataa     2880

cagctttgtc gtggatggtg acacactgaa ggaatgccca ctcaaacata gagcatggaa     2940

cagctttctt gtggaggatc atgggttcgg ggtatttcac actagtgtct ggctcaaggt     3000

tagagaagat tattcattag agtgtgatcc agccgttatt ggaacagctg ttaagggaaa     3060

ggaggctgta cacagtgatc taggctactg gattgagagt gagaagaatg acacatggag     3120

gctgaagagg gcccatctga tcgagatgaa aacatgtgaa tggccaaagt cccacacatt     3180

gtggacagat ggaatagaag agagtgatct gatcataccc aagtctttag ctgggccact     3240

cagccatcac aataccagag agggctacag gacccaaatg aaagggccat ggcacagtga     3300

agagcttgaa attcggtttg aggaatgccc aggcactaag gtccacgtgg aggaaacatg     3360

tggaacaaga ggaccatctc tgagatcaac cactgcaagc ggaagggtga tcgaggaatg     3420

gtgctgcagg gagtgcacaa tgcccccact gtcgttccgg gctaaagatg gctgttggta     3480

tggaatggag ataaggccca ggaaagaacc agaaagcaac ttagtaaggt caatggtgac     3540

tgcaggatca actgatcaca tggaccactt ctcccttgga gtgcttgtga tcctgctcat     3600

ggtgcaggaa gggctgaaga agagaatgac cacaaagatc atcataagca catcaatggc     3660

agtgctggta gctatgatcc tgggaggatt ttcaatgagt gacctggcta agcttgcaat     3720

tttgatgggt gccaccttcg cggaaatgaa cactggagga gatgtagctc atctggcgct     3780

gatagcggca ttcaaagtca gaccagcgtt gctggtatct ttcatcttca gagctaattg     3840

gacaccccgt gaaagcatgc tgctggcctt ggcctcgtgt cttttgcaaa ctgcgatctc     3900

cgccttggaa ggcgacctga tggttctcat caatggtttt gctttggcct ggttggcaat     3960

acgagcgatg gttgttccac gcactgataa catcaccttg gcaatcctgg ctgctctgac     4020

accactggcc cggggcacac tgcttgtggc gtggagagca ggccttgcta cttgcggggg     4080

gtttatgctc ctctctctga agggaaaagg cagtgtgaag aagaacttac catttgtcat     4140

ggccctggga ctaaccgctg tgaggctggt cgaccccatc aacgtggtgg gactgctgtt     4200

gctcacaagg agtgggaagc ggagctggcc ccctagcgaa gtactcacag ctgttggcct     4260

gatatgcgca ttggctggag ggttcgccaa ggcagatata gagatggctg ggcccatggc     4320

cgcggtcggt ctgctaattg tcagttacgt ggtctcagga aagagtgtgg acatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa agatgcggaa gtcactggaa acagtccccg     4440

gctcgatgtg gcgctagatg agagtggtga tttctccctg gtggaggatg acggtccccc     4500

catgagagag atcatactca aggtggtcct gatgaccatc tgtggcatga acccaatagc     4560

catacccttt gcagctggag cgtggtacgt atacgtgaag actggaaaaa ggagtggtgc     4620

tctatgggat gtgcctgctc ccaaggaagt aaaaaagggg gagaccacag atggagtgta     4680

cagagtaatg actcgtagac tgctaggttc aacacaagtt ggagtgggag ttatgcaaga     4740

gggggtcttt cacactatgt ggcacgtcac aaaaggatcc gcgctgagaa gcggtgaagg     4800

gagacttgat ccatactggg gagatgtcaa gcaggatctg gtgtcatact gtggtccatg     4860

gaagctagat gccgcctggg atgggcacag cgaggtgcag ctcttggccg tgccccccgg     4920

agagagagcg aggaacatcc agactctgcc cggaatattt aagacaaagg atggggacat     4980

tggagcggtt gcgctggatt acccagcagg aacttcagga tctccaatcc tagacaagtg     5040

tgggagagtg ataggacttt atggcaatgg ggtcgtgatc aaaaacggga gttatgttag     5100

tgccatcacc caagggagga gggaggaaga gactcctgtt gagtgcttcg agccctcgat     5160

gctgaagaag aagcagctaa ctgtcttaga cttgcatcct ggagctggga aaaccaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaacaaga ctccgtactg tgatcttagc     5280

tccaaccagg gttgtcgctg ctgaaatgga ggaggccctt agagggcttc cagtgcgtta     5340

tatgacaaca gcagtcaatg tcacccactc tggaacagaa atcgtcgact taatgtgcca     5400

tgccaccttc acttcacgtc tactacagcc aatcagagtc cccaactata atctgtatat     5460

tatggatgag gcccacttca cagatccctc aagtatagca gcaagaggat acatttcaac     5520

aagggttgag atgggcgagg cggctgccat cttcatgacc gccacgccac caggaacccg     5580

tgacgcattt ccggactcca actcaccaat tatggacacc gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac ggatcattct ggaaaaacag tttggtttgt     5700

tccaagcgtg aggaacggca atgagatcgc agcttgtctg acaaaggctg gaaaacgggt     5760

catacagctc agcagaaaga cttttgagac agagttccag aaaacaaaac atcaagagtg     5820

ggactttgtc gtgacaactg acatttcaga gatgggcgcc aactttaaag ctgaccgtgt     5880

catagattcc aggagatgcc taaagccggt catacttgat ggcgagagag tcattctggc     5940

tggacccatg cctgtcacac atgccagcgc tgcccagagg agggggcgca taggcaggaa     6000

tcccaacaaa cctggagatg agtatctgta tggaggtggg tgcgcagaga ctgacgaaga     6060

ccatgcacac tggcttgaag caagaatgct ccttgacaat atttacctcc aagatggcct     6120

catagcctcg ctctatcgac ctgaggccga caaagtagca gccattgagg gagagttcaa     6180

gcttaggacg gagcaaagga agacctttgt ggaactcatg aaaagaggag atcttcctgt     6240

ttggctggcc tatcaggttg catctgccgg aataacctac acagatagaa gatggtgctt     6300

tgatggcacg accaacaaca ccataatgga agacagtgtg ccggcagagg tgtggaccag     6360

acacggagag aaaagagtgc tcaaaccgag gtggatggac gccagagttt gttcagatca     6420

tgcggccctg aagtcattca aggagtttgc cgctgggaaa agaggagcgg cttttggagt     6480

gatggaagcc ctgggaacac tgccaggaca catgacagag agattccagg aagccattga     6540

caacctcgct gtgctcatgc gggcagagac tggaagcagg ccttacaaag ccgcggcggc     6600

ccaattgccg gagaccctag agaccataat gcttttgggg ttgctgggaa cagtctcgct     6660

gggaatcttc ttcgtcttga tgaggaacaa gggcataggg aagatgggct ttggaatggt     6720

gactcttggg gccagcgcat ggctcatgtg gctctcggaa attgagccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcctattgct ggtggtgctc atacctgagc cagaaaagca     6840

aagatctccc caggacaacc aaatggcaat catcatcatg gtagcagtag gtcttctggg     6900

cttgattacc gccaatgaac tcggatggtt ggagagaaca aagagtgacc taagccatct     6960

aatgggaagg agagaggagg gggcaaccat aggattctca atggacattg acctgcggcc     7020

agcctcagct tgggccatct atgctgcctt gacaactttc attaccccag ccgtccaaca     7080

tgcagtgacc acctcataca acaactactc cttaatggcg atggccacgc aagctggagt     7140

gttgtttggc atgggcaaag ggatgccatt ctacgcatgg gactttggag tcccgctgct     7200

aatgataggt tgctactcac aattaacacc cctgacccta atagtggcca tcattttgct     7260

cgtggcgcac tacatgtact tgatcccagg gctgcaggca gcagctgcgc gtgctgccca     7320

gaagagaacg gcagctggca tcatgaagaa ccctgttgtg gatggaatag tggtgactga     7380

cattgacaca atgacaattg acccccaagt ggagaaaaag atgggacagg tgctactcat     7440

agcagtagcc gtctccagcg ccatactgtc gcggaccgcc tgggggtggg gggaggctgg     7500

ggctctgatc acagccgcaa cttccacttt gtgggaaggc tctccgaaca agtactggaa     7560

ctcctctaca gccacttcac tgtgtaacat ttttagggga agttacttgg ctggagcttc     7620

tctaatctac acagtaacaa gaaacgctgg cttggtcaag agacgtgggg gtggaacagg     7680

agagaccctg ggagagaaat ggaaggcccg cttgaaccag atgtcggccc tggagttcta     7740

ctcctacaaa aagtcaggca tcaccgaggt gtgcagagaa gaggcccgcc gcgccctcaa     7800

ggacggtgtg gcaacgggag gccatgctgt gtcccgagga agtgcaaagc tgagatggtt     7860

ggtggagcgg ggatacctgc agccctatgg aaaggtcatt gatcttggat gtggcagagg     7920

gggctggagt tactacgtcg ccaccatccg caaagttcaa gaagtgaaag gatacacaaa     7980

aggaggccct ggtcatgaag aacccgtgtt ggtgcaaagc tatgggtgga acatagtccg     8040

tcttaagagt ggggtggacg tctttcatat ggcggctgag ccgtgtgaca cgttgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagaa gcacggacgc tcagagtcct     8160

ctccatggtg ggggattggc ttgaaaaaag accaggagcc ttttgtataa aagtgttgtg     8220

cccatacacc agcactatga tggaaaccct ggagcgactg cagcgtaggt atgggggagg     8280

actggtcaga gtgccactct cccgcaactc tacacatgag atgtactggg tctctggagc     8340

gaaaagcaac accataaaaa gtgtgtccac cacgagccag ctcctcttgg ggcgcatgga     8400

cgggcctagg aggccagtga aatatgagga ggatgtgaat ctcggctctg gcacgcgggc     8460

tgtggtaagc tgcgctgaag ctcccaacat gaagatcatt ggtaaccgca ttgaaaggat     8520

ccgcagtgag cacgcggaaa cgtggttctt tgacgagaac cacccatata ggacatgggc     8580

ttaccatgga agctatgagg cccccacaca agggtcagcg tcctctctaa taaacggggt     8640

tgtcaggctc ctgtcaaaac cctgggatgt ggtgactgga gtcacaggaa tagccatgac     8700

cgacaccaca ccgtatggtc agcaaagagt tttcaaggaa aaagtggaca ctagggtgcc     8760

agacccccaa gaaggcactc gtcaggttat gagcatggtc tcttcctggt tgtggaaaga     8820

gctaggcaaa cacaaacggc cacgagtctg caccaaagaa gagttcatca acaaggttcg     8880

tagcaatgca gcattagggg caatatttga agaggaaaaa gagtggaaga ctgcagtgga     8940

agctgtgaac gatccaaggt tctgggctct agtggacaag gaaagagagc accacctgag     9000

aggagagtgc cagagctgtg tgtacaacat gatgggaaaa agagaaaaga aacaagggga     9060

atttggaaag gccaagggca gccgcgccat ctggtatatg tggctagggg ctagatttct     9120

agagttcgaa gcccttggat tcttgaacga ggatcactgg atggggagag agaactcagg     9180

aggtggtgtt gaagggctgg gattacaaag actcggatat gtcctagaag agatgagtcg     9240

tataccagga ggaaggatgt atgcagatga cactgctggc tgggacaccc gcattagcag     9300

gtttgatctg gagaatgaag ctctaatcac caaccaaatg gagaaagggc acagggcctt     9360

ggcattggcc ataatcaagt acacatacca aaacaaagtg gtaaaggtcc ttagaccagc     9420

tgaaaaaggg aaaacagtta tggacattat ttcgagacaa gaccaaaggg ggagcggaca     9480

agttgtcact tacgctctta acacatttac caacctagtg gtgcaactca ttcggaatat     9540

ggaggctgag gaagttctag agatgcaaga cttgtggctg ctgcggaggt cagagaaagt     9600

gaccaactgg ttgcagagca acggatggga taggctcaaa cgaatggcag tcagtggaga     9660

tgattgcgtt gtgaagccaa ttgatgatag gtttgcacat gccctcaggt tcttgaatga     9720

tatgggaaaa gttaggaagg acacacaaga gtggaaaccc tcaactggat gggacaactg     9780

ggaagaagtt ccgttttgct cccaccactt caacaagctc catctcaagg acgggaggtc     9840

cattgtggtt ccctgccgcc accaagatga actgattggc cgggcccgcg tctctccagg     9900

ggcgggatgg agcatccggg agactgcttg cctagcaaaa tcatatgcgc aaatgtggca     9960

gctcctttat ttccacagaa gggacctccg actgatggcc aatgccattt gttcatctgt    10020

gccagttgac tgggttccaa ctgggagaac tacctggtca atccatggaa agggagaatg    10080

gatgaccact gaagacatgc ttgtggtgtg gaacagagtg tggattgagg agaacgacca    10140

catggaagac aagaccccag ttacgaaatg gacagacatt ccctatttgg gaaaaaggga    10200

agacttgtgg tgtggatctc tcatagggca cagaccgcgc accacctggg ctgagaacat    10260

taaaaacaca gtcaacatgg tgcgcaggat cataggtgat gaagaaaagt acatggacta    10320

cctatccacc caagttcgct acttgggtga agaagggtct acacctggag tgctgtaagc    10380

accaatctta atgttgtcag gcctgctagt cagccacagc ttggggaaag ctgtgcagcc    10440

tgtgaccccc ccaggagaag ctgggaaacc aagcctatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggac actgagtcaa aaaaccccac    10560

gcgcttggag gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagatcagct gtggatctcc agaagaggga ctagtggtta gagga         10675


<210>  131
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV envelope amino acid sequence

<400>  131

Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
1               5                   10                  15      


Phe Leu Ser Thr Ala Val Ser Ala 
            20                  


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PreScission Protease cleavage site amino acid sequence

<400>  132

Leu Glu Val Leu Phe Asn Gly Pro Gly 
1               5                   


<210>  133
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hexahistidine motif amino acid sequence

<400>  133

His His His His His His 
1               5       


<210>  134
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VL CDR1 (IMGT)


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y or H

<400>  134

Gln Ser Ile Ser Ser Xaa 
1               5       


<210>  135
<211>  3
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VL CDR2 (IMGT)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is A or Q

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is A or D

<400>  135

Xaa Xaa Ser 
1           


<210>  136
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VL CDR3 (IMGT)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is L, Y, or W

<400>  136

Gln Gln Xaa Tyr Ser Thr Pro Xaa Thr 
1               5                   


<210>  137
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VL ABR1 (Paratome)


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is Y or H

<400>  137

Gln Ser Ile Ser Ser Xaa Leu Asn 
1               5               


<210>  138
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VL ABR2 (Paratome)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is F or L

<400>  138

Xaa Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210>  139
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VL ABR3 (Paratome)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is L, Y or W

<400>  139

Gln Gln Xaa Tyr Ser Thr Pro Xaa 
1               5               


<210>  140
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  140

Leu Ala Leu Ala Pro Gly 
1               5       


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of thrombin cleavage site

<400>  141

Leu Val Pro Arg Gly Ser Pro 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of cleavage site recognized by Tobacco Etch Virus (TEV) 
       protease


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is G or S

<400>  142

Glu Asn Leu Tyr Phe Gln Xaa 
1               5           


<210>  143
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH CDR1

<400>  143

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  144
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH CDR2

<400>  144

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  145
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH CDR3

<400>  145

Ala Arg Asp Arg Arg Gly Phe Asp Tyr 
1               5                   


<210>  146
<211>  13
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH CDR3

<400>  146

Ala Arg Trp Gly Gly Lys Arg Gly Gly Ala Phe Asp Ile 
1               5                   10              


<210>  147
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH CDR3

<400>  147

Ala Arg Leu Ile Ala Ala Ala Gly Asp Tyr 
1               5                   10  


<210>  148
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH CDR3

<400>  148

Ala Arg Gly Pro Val Gln Leu Glu Arg Arg Pro Leu Gly Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH ABR1

<400>  149

Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   


<210>  150
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH ABR2

<400>  150

Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala 
1               5                   10                  


<210>  151
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH ABR3

<400>  151

Ala Arg Asp Arg Arg Gly Phe Asp Tyr 
1               5                   


<210>  152
<211>  13
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH ABR3

<400>  152

Ala Arg Trp Gly Gly Lys Arg Gly Gly Ala Phe Asp Ile 
1               5                   10              


<210>  153
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH ABR3

<400>  153

Ala Arg Leu Ile Ala Ala Ala Gly Asp Tyr 
1               5                   10  


<210>  154
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  VH ABR3

<400>  154

Ala Arg Gly Pro Val Gln Leu Glu Arg Arg Pro Leu Gly Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  155
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  155

Cys Ala Arg Asp Arg Arg Gly Phe Asp Tyr Trp 
1               5                   10      


<210>  156
<211>  19
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  156

Cys Ala Arg Gly Pro Val Gln Leu Glu Arg Arg Pro Leu Gly Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  157
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  157

Cys Ala Arg Trp Gly Gly Lys Arg Gly Gly Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  158
<211>  12
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  158

Cys Ala Arg Leu Ile Ala Ala Ala Gly Asp Tyr Trp 
1               5                   10          


<210>  159
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  159

Cys Gln Gln Thr Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  160
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  160

Cys Gln Ala Trp Asp Ser Ser Thr Val 
1               5                   


<210>  161
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  161

Cys Gln Gln Ser Tyr Ser Thr Pro Tyr Thr Phe 
1               5                   10      


<210>  162
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  CDR3

<400>  162

Cys Gln Gln Ser Tyr Ser Thr Pro Trp Thr Phe 
1               5                   10      


<210>  163
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  163

Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
1               5                   10                  15      


Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe 
            20                  25                  30          


Ser Lys 
        


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  164

Leu Val Arg Ser Met Val Thr Ala 
1               5               


<210>  165
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (cleavage site and hexahistidine motif)

<400>  165

Leu Val Arg Ser Met Val Thr Ala Leu Glu Val Leu Phe Asn Gly Pro 
1               5                   10                  15      


Gly His His His His His His 
            20              


<210>  166
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic NS1 polypeptide (comprising a fragment of a Zika virus 
       evelope protein, and a Zika virus NS1 polypeptide)

<400>  166

Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
1               5                   10                  15      


Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe 
            20                  25                  30          


Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr Asn Asp 
        35                  40                  45              


Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro Arg 
    50                  55                  60                  


Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile Cys Gly 
65                  70                  75                  80  


Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser Val Glu 
                85                  90                  95      


Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr Val 
            100                 105                 110         


Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg Leu 
        115                 120                 125             


Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly Lys 
    130                 135                 140                 


Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val Val Asp 
145                 150                 155                 160 


Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp Asn Ser 
                165                 170                 175     


Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser Val Trp 
            180                 185                 190         


Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val Ile 
        195                 200                 205             


Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu Gly Tyr 
    210                 215                 220                 


Trp Ile Glu Ser Glu Lys Asn Asp Thr Trp Arg Leu Lys Arg Ala His 
225                 230                 235                 240 


Leu Ile Glu Met Lys Thr Cys Glu Trp Pro Lys Ser His Thr Leu Trp 
                245                 250                 255     


Thr Asp Gly Ile Glu Glu Ser Asp Leu Ile Ile Pro Lys Ser Leu Ala 
            260                 265                 270         


Gly Pro Leu Ser His His Asn Thr Arg Glu Gly Tyr Arg Thr Gln Met 
        275                 280                 285             


Lys Gly Pro Trp His Ser Glu Glu Leu Glu Ile Arg Phe Glu Glu Cys 
    290                 295                 300                 


Pro Gly Thr Lys Val His Val Glu Glu Thr Cys Gly Thr Arg Gly Pro 
305                 310                 315                 320 


Ser Leu Arg Ser Thr Thr Ala Ser Gly Arg Val Ile Glu Glu Trp Cys 
                325                 330                 335     


Cys Arg Glu Cys Thr Met Pro Pro Leu Ser Phe Arg Ala Lys Asp Gly 
            340                 345                 350         


Cys Trp Tyr Gly Met Glu Ile Arg Pro Arg Lys Glu Pro Glu Ser Asn 
        355                 360                 365             


Leu Val Arg Ser Met Val Thr Ala 
    370                 375     


<210>  167
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic NS1 polypeptide (comprising a fragment of a Zika virus 
       evelope protein, a Zika virus NS1 polypeptide, a cleavage site, 
       and a hexahistidine motif)

<400>  167

Met Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu 
1               5                   10                  15      


Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp 
            20                  25                  30          


Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr Asn 
        35                  40                  45              


Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro 
    50                  55                  60                  


Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile Cys 
65                  70                  75                  80  


Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser Val 
                85                  90                  95      


Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr 
            100                 105                 110         


Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg 
        115                 120                 125             


Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly 
    130                 135                 140                 


Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val Val 
145                 150                 155                 160 


Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp Asn 
                165                 170                 175     


Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser Val 
            180                 185                 190         


Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val 
        195                 200                 205             


Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu Gly 
    210                 215                 220                 


Tyr Trp Ile Glu Ser Glu Lys Asn Asp Thr Trp Arg Leu Lys Arg Ala 
225                 230                 235                 240 


His Leu Ile Glu Met Lys Thr Cys Glu Trp Pro Lys Ser His Thr Leu 
                245                 250                 255     


Trp Thr Asp Gly Ile Glu Glu Ser Asp Leu Ile Ile Pro Lys Ser Leu 
            260                 265                 270         


Ala Gly Pro Leu Ser His His Asn Thr Arg Glu Gly Tyr Arg Thr Gln 
        275                 280                 285             


Met Lys Gly Pro Trp His Ser Glu Glu Leu Glu Ile Arg Phe Glu Glu 
    290                 295                 300                 


Cys Pro Gly Thr Lys Val His Val Glu Glu Thr Cys Gly Thr Arg Gly 
305                 310                 315                 320 


Pro Ser Leu Arg Ser Thr Thr Ala Ser Gly Arg Val Ile Glu Glu Trp 
                325                 330                 335     


Cys Cys Arg Glu Cys Thr Met Pro Pro Leu Ser Phe Arg Ala Lys Asp 
            340                 345                 350         


Gly Cys Trp Tyr Gly Met Glu Ile Arg Pro Arg Lys Glu Pro Glu Ser 
        355                 360                 365             


Asn Leu Val Arg Ser Met Val Thr Ala Leu Glu Val Leu Phe Gln Gly 
    370                 375                 380                 


Pro Gly His His His His His His 
385                 390         


<210>  168
<211>  1056
<212>  DNA
<213>  Zika Virus

<220>
<223>  PRVABC59 virus NS1 nucleotide sequence

<400>  168
gatgtggggt gctcggtgga cttctcaaag aaggagacga gatgcggtac aggggtgttc       60

gtctataacg acgttgaagc ctggagggac aggtacaagt accatcctga ctccccccgt      120

agattggcag cagcagtcaa gcaagcctgg gaagatggta tctgcgggat ctcctctgtt      180

tcaagaatgg aaaacatcat gtggagatca gtagaagggg agctcaacgc aatcctggaa      240

gagaatggag ttcaactgac ggtcgttgtg ggatctgtaa aaaaccccat gtggagaggt      300

ccacagagat tgcccgtgcc tgtgaacgag ctgccccacg gctggaaggc ttgggggaaa      360

tcgtatttcg tcagagcagc aaagacaaat aacagctttg tcgtggatgg tgacacactg      420

aaggaatgcc cactcaaaca tagagcatgg aacagctttc ttgtggagga tcatgggttc      480

ggggtatttc acactagtgt ctggctcaag gttagagaag attattcatt agagtgtgat      540

ccagccgtta ttggaacagc tgttaaggga aaggaggctg tacacagtga tctaggctac      600

tggattgaga gtgagaagaa tgacacatgg aggctgaaga gggcccatct gatcgagatg      660

aaaacatgtg aatggccaaa gtcccacaca ttgtggacag atggaataga agagagtgat      720

ctgatcatac ccaagtcttt agctgggcca ctcagccatc acaataccag agagggctac      780

aggacccaaa tgaaagggcc atggcacagt gaagagcttg aaattcggtt tgaggaatgc      840

ccaggcacta aggtccacgt ggaggaaaca tgtggaacaa gaggaccatc tctgagatca      900

accactgcaa gcggaagggt gatcgaggaa tggtgctgca gggagtgcac aatgccccca      960

ctgtcgttcc gggctaaaga tggctgttgg tatggaatgg agataaggcc caggaaagaa     1020

ccagaaagca acttagtaag gtcaatggtg actgca                               1056

