                         SEQUENCE LISTING

<110>  Mayo Foundation for Medical Education and Research
 
<120>  METHODS AND MATERIALS FOR TREATING CANCER

<130>  07039-1816WO1

<150>  62/753,732
<151>  2018-10-31

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1458
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence encoding a chimeric antigen receptor 
       targeting a CD19 antigen

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgc                                                   1458


<210>  2
<211>  7212
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence encoding a modified viral envelope 
       polypeptide capable of targeting a CD3 antigen

<400>  2
gaattcgagc tcgccccgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat      600

ccagcctccg ggggatcgat ccccccgatc ctgagaactt cagggtgagt ttggggaccc      660

ttgattgttc tttctttttc gctattgtaa aattcatgtt atatggaggg ggcaaagttt      720

tcagggtgtt gtttagaatg ggaagatgtc ccttgtatca ccatggaccc tcatgataat      780

tttgtttctt tcactttcta ctctgttgac aaccattgtc tcctcttatt ttcttttcat      840

tttctgtaac tttttcgtta aactttagct tgcatttgta acgaattttt aaattcactt      900

ttgtttattt gtcagattgt aagtactttc tctaatcact tttttttcaa ggcaatcagg      960

gtatattata ttgtacttca gcacagtttt agagaacaat tgttataatt aaatgataag     1020

gtagaatatt tctgcatata aattctggct ggcgtggaaa tattcttatt ggtagaaaca     1080

actacatcct ggtcatcatc ctgcctttct ctttatggtt acaatgatat acactgtttg     1140

agatgaggat aaaatactct gagtccaaac cgggcccctc tgctaaccat gttcatgcct     1200

tcttcttttt cctacagctc ctgggcaacg tgctggttat tgtgctgtct catcattttg     1260

gcaaagaatt gtaatacgac tcactatagg gcgaattcgg atcccccggt agttaattaa     1320

aacttagggt gcaagatcat ccacaatgag cccccagaga gaccgcatca acgcattcta     1380

caaggacaac ccacatagca aagggagccg catcgtgatt aatcgagagc acctgatgat     1440

cgatagacct tacgtgctgc tggctgtgct gttcgtcatg tttctgagcc tgattggtct     1500

gctggcaatc gccggcatta gactgcaccg cgccgctatc tatacagcag agattcataa     1560

gtccctgtct accaacctgg acgtgacaaa ttccatcgaa catcaggtga aggatgtcct     1620

gactccactg ttcaaaatca ttggtgacga ggtcggactg cgaactccac agcggttcac     1680

cgacctggtg aagtttatca gcgataagat caagttcctg aacccagacc gggagtacga     1740

ctttagggat ctgacctggt gcatcaaccc ccctgaacgg atcaagctga actacgacca     1800

gtattgtgca gatgtcgcag ccgaggaact gatgaacgcc ctggtgaatt ccacactgct     1860

ggagactagg accacaaacc agttcctggc cgtgtctaag ggaaattgcc ctgggccaac     1920

taccatccgc ggccagtttt caaatatgag tctgtcactg ctggatctgt acctgagccg     1980

aggatataac gtgagctcca ttgtcaccat gacatcccag gggatgtacg gcggaaccta     2040

tctggtggga aagccagacc tgaattccaa agggtctgag ctgagtcagc cttcaatgta     2100

ccgagtgttc gaagtgggcg tcatccgaaa cccaggactg ggagcacccg tgttccacat     2160

gaccaattat tttgagcagc ccattagcaa ggatctgtcc aactgtatgg tggccctggg     2220

tgaactgaaa ctggctgcac tgtgccatag gggcgacagt atcacaattc cctgtagagg     2280

gtccggcaag ggcgtgtctt ttcagctggt gaagctgggc gtctggaaaa gccctactga     2340

tatgcacagt tgggtcccac tgtcaaccga cgatcccgtg atcgatagac tgtacctgtc     2400

tagtcatcgc ggagtcatta ccgacaacca ggctaattgg gcagtgccta caactagaac     2460

cgacgataag ctgcagaaag agacatgctt ccagcaggcc tgtaagggga aaatccaggc     2520

tctgtgcgag aatctggaat gggctcctct gaaggattct cgcattccaa gttatggagt     2580

gctgtcagtc aacctgagcc tggccgctga acccaagatc aaaattgcct ctggatttgg     2640

gcctctgatc actcacggta gcggcatgga cctgtacaag tccaaccata acaacgtgta     2700

ctggctgact attccaccca tgaaaaacct ggctctgggc gtgatcaata ccctgaagtg     2760

gattcctcgc ctgaaggtca gcccatacct gtttacagtg cccatcgagg aagccgacga     2820

ggattgtcgg gctccaacat acctgcccgc agaagtgact ggcgacgtga aactgtcaag     2880

caacctggtc atcctgccag gacaggacct gcagtacgtg ctggctactt atgatacctc     2940

tggagtcgaa catgcagtgg tctactacgt gtacagccct ggcgggtctt tcagttacgt     3000

gtatcctttt cggctgccaa tcaagggtac accaattgag ctgcaggtgg aatgcttcac     3060

ttgggcccag aggctgtggt gcagacactt ttgcgtgctg gctgattcag agagcggggg     3120

tcacctgacc cattctggaa tggtggggat ggaagtcagt tgtacagtga acagggagga     3180

cgaagccaat atcgagggaa gggcggccca gccggcccag gtgcagctgc agcagagcgg     3240

cgccgagctg gccaggcccg gcgccagcgt gaagatgagc tgcaaggcca gcggctacac     3300

cttcaccagg tacaccatgc actgggtgaa gcagaggccc ggccagggcc tggagtggat     3360

cggctacatc aaccccagca ggggctacac caactacaac cagaagttca aggacaaggc     3420

caccctgacc accgacaaga gcagcagcac cgcctacatg cagctgagca gcctgaccag     3480

cgaggacagc gccgtgtact actgcgccag gtactacgac gaccactact gcctggacta     3540

ctggggccag ggcaccaccc tgaccgtgag cagcgccggc ggcggcggca gcggcggcgg     3600

cggcagcggc ggcggcggca gccagatcgt gctgacccag agccccgcca tcatgagcgc     3660

cagccccggc gagaaggtga ccatgacctg cagcgccagc agcagcgtga gctacatgaa     3720

ctggtaccag cagaagagcg gcaccagccc caagaggtgg atctacgaca ccagcaagct     3780

ggccagcggc gtgcccgccc acttcagggg cagcggcagc ggcaccagct acagcctgac     3840

catcagcggc atggaggccg aggacgccgc cacctactac tgccagcagt ggagcagcaa     3900

ccccttcacc ttcggcagcg gcaccaagct ggagatcaac agggccgaca ccgcccccac     3960

cgcggccgca agaggatcgc atcaccatca ccatcactga tagtttgtac tagtgtgaaa     4020

tagacatcag aattaagaaa aacgtagggt ccaagtggtt ccccgttatg gactcgctat     4080

ctgtcaacca gatcttatac cctgaagttc acctagatag cccgatagtt accaataaga     4140

tagtagccat cctggagtat gctcgactgt ttaaacctgc aggcatgcaa gctgatcttt     4200

ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct     4260

aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg     4320

gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt     4380

tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc     4440

agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag     4500

gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt     4560

ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg     4620

tccctcttct cttatggaga tccctcgagg agctttttgc aaaagcctag gcctccaaaa     4680

aagcctcttc actacttctg gaatagctca gaggccgcgg cctcggcctc tgcataaata     4740

aaaaaaatta gtcagccatg gggcggagaa tgggcggaac tgggcggagt taggggcggg     4800

atgggcggag ttaggggcgg gactatggtt gctgactaat tgctgcatta atgaatcggc     4860

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     4920

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     4980

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     5040

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     5100

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     5160

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     5220

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     5280

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     5340

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     5400

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     5460

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     5520

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     5580

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     5640

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     5700

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     5760

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     5820

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     5880

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     5940

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     6000

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     6060

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     6120

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     6180

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     6240

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     6300

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     6360

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     6420

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     6480

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     6540

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     6600

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     6660

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     6720

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     6780

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa     6840

accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctttcgtctc     6900

gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga gacggtcaca     6960

gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt     7020

ggcgggtgtc ggggctggct taactatgcg gcatcagagc agattgtact gagagtgcac     7080

cattcgacgc tctcccttat gcgactcctg cattaggaag cagcccagta gtaggttgag     7140

gccgttgagc accgccgccg caaggaatgg tctggcttat cgaaattaat acgactcact     7200

atagggagac cg                                                         7212


