                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Muthumani, Kar
       Weiner, David
 
<120>  A NOVEL DNA VACCINE AGAINST CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS
        (CCHFV)

<130>  206193-0013-00WO

<150>  US 62/754,821
<151>  2018-11-02

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  5046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CCHFV-Glycoprotein sequence

<400>  1
cacaccctgc tggtctgttt tattctgtat ctgcagctgt gcggcctggg cggcgcccac       60

ggaaacaata gcaacaccac agagcacaac accaatacca caacccctgg cagccagtcc      120

ccaagctcca agcctcccgt gagcacaacc ccctctatcc acacccctga gtctagcaca      180

aagccaacaa ccccaagcga gggcctggag ggctccggag aggtgtacac aaccccaccc      240

aacacaaccc agggcctgtc tcccagcgag acaacccccg agcctgccac aaccacaacc      300

acacagaacc caaccacagc cgatcccgac acatcctcta ccaattccac cacacaggat      360

acccccacca cagtgacatc tcctagctcc tctccttcta caccaagcac ccctcaggga      420

caccaccctc cagtgcgctc cctgctgtct gtgagctccc caggaccaga cgagaagacc      480

acacctaccc caagccccgg cgagtctagc gagacacctt cctctcacag cgccagcagg      540

aggcctccca ccccacccac cacaacccag gtgagcaccg agaacaatag ccactccaca      600

ccaaggcagt ccgagagctc ccagccagcc acctctccag gcctgatgac aagcccagca      660

cagatcctga gcgccccttc cgccacccca atcgcaatcc aggataccca cccttcccca      720

acaaacaggt ctaagagaaa tctggagatg gagatcatcc tgacactgtc ccagggcctg      780

aagaagtact atggcaagat cctgaagctg ctgcacctga ccctggagga ggacacagag      840

ggcctgctgg agtggtgtaa gagaaacctg ggcctgagct gcgacgatga cttctttcag      900

aagcggatcg aggagttctt tatcaccggc gagggctact ttaatgaggt gctgcagttc      960

aagacactgt ctaccctgag ccctaccgag ccatctcacg caggcctgcc aacagcagag     1020

cctttcaaga gctattttgc caagggcttc ctgtccatcg attctggcta cttttccgcc     1080

aagtgttatc ccggcagatc tagctccggc ctgcagctga tcaacgtgac ccagcaccct     1140

gcaaggatcg cagagacacc aggacctaag acaacctccc tgaagaccat caactgcatc     1200

aatctgaggg ccagcgtgtt caaggagcac agagaggtgg agatcaatgt gctgctgcca     1260

cagatcgccg tgaacctgag caattgtcac gtggtcatca agtcccacgt gtgcgactac     1320

tctctggata ccgacggccc agtgagactg ccccacatca tccacgaggg caccttcatc     1380

cccggcacat ataagatcgt gatcgataag aagaacaagc tgaatgaccg gtgtacactg     1440

gtgaccaact gcgtgatcaa gggaagggag gtgcgcaagg gacagagcgt gctgcgccag     1500

tacaagaccg agatcaagat cggcaaggcc agcacaggct ccaggaagct gctgtccgag     1560

gagccaggcg atgactgtat ctctaggacc cagctgctga gaacagagac agccgagatc     1620

cacgatgaca actacggcgg acctggcgat aagatcacca tctgtaatgg cagcacaatc     1680

gtggaccagc gcctgggctc cgagctgggc tgctatacca tcaacagggt gaagtctttt     1740

aagctgtgcg agaatagcgc cacaggcaag acctgcgaga tcgactccac ccctgtgaag     1800

tgtcgccagg gcttctgcct gaagatcaca caggagggaa ggggacacgt gaagctgtct     1860

cgcggcagcg aggtggtgct ggatgcctgt gactctagct gcgaagtgat gatcccaaag     1920

ggcaccggcg atatcctggt ggactgcagc ggcggccagc agcacttcct gaaggataac     1980

ctgatcgacc tgggctgtcc caagatccct ctgctgggca agatggccat ctacatctgc     2040

agaatgagca atcaccctaa gacaaccatg gccttcctgt tttggttctc ctttggctac     2100

gtgatcacct gcatcttttg taaggccctg ttctatctgc tgatcatcat cggcacactg     2160

ggcaagcgga agaagcagta tcgcgagctg aagccccaga catgcaccat ctgtgagaca     2220

gcccctgtga acgccatcga tgccgagatg cacgacctga actgtagcta caatatctgc     2280

ccttattgtg ccagccggct gacctccgac ggcctggcaa ggcacgtgac acagtgccca     2340

aagaggaagg agaaggtgga ggagacagag ctgtacctga atctggagcg catcccctgg     2400

gtgcggagga agctgctgca ggtgtctgag agcaccggcg tggccctgaa gaggtcctct     2460

tggctgatcg tgctgctggt gctgctgaca gtgtccctgt ctcctgtgca gagcgcccca     2520

gtgggacacg gcaagacaat cgagacatat cagacacggg agggctttac ctccatctgt     2580

ctgttcatgc tgggcagcat cctgttcatc gtgtcctgcc tggtgaaggg cctggtggat     2640

agcgtgtcca actctttctt tccaggcctg tccgtgtgca agacatgttc catcggctct     2700

atcaatggct ttgagatcga gtctcacaag tgctactgta gcctgttctg ctgtccctat     2760

tgccggcact gttctgccga ccgcgagatc caccagctgc acctgtctat ctgcaagaag     2820

aggaagaccg gcagcaacgt gatgctggcc gtgtgcaagc ggatgtgctt tagggcaaca     2880

gaggccagct ccaacagggc cctgctgatc agatccatca tcaatacaac cttcgtgatc     2940

tgtatcctga ccctggccat ctgcgtggtg agcacatccg ccgtggagat ggagaatctg     3000

ccagccggca cctgggagag agaggaggat ctgacaaact tttgtcacca ggagtgccag     3060

gtgacagaga cagagtgcct gtgcccatac gaggccctgg tgctgaggaa gcctctgttc     3120

ctggacagca tcgtgaaggg catgaagaac ctgctgaatt ctaccagcct ggagacatcc     3180

ctgtctatcg aggccccatg gggcgccatc aacgtgcagt ccacctttaa gcccaccgtg     3240

tctacagcca atatcgccct gagctggtct agcgtggagc acagaggcaa caagatcctg     3300

gtgaccggcc ggagcgagtc catcatgaag ctggaggaga gaacaggcgt gtcctgggat     3360

ctgggcgtgg aggacgcctc tgagagcaag ctgctgaccg tgtctatcat ggacctgtct     3420

cagatgtaca gccccgtgtt cgagtatctg agcggcgata gacaggtgga ggagtggcca     3480

aaggcaacat gtaccggcga ctgcccagag cggtgcggat gtacctcctc tacatgtctg     3540

cacaaggagt ggcctcacag caggaactgg agatgtaatc caacctggtg ctggggcgtg     3600

ggaaccggat gcacatgctg tggcgtggat gtgaaggacc tgtttacaga tcacatgttc     3660

gtgaagtgga aggtggagta catcaagacc gaggccatcg tgtgcgtgga gctgacatcc     3720

caggagagac agtgctctct gatcgaggca ggaacccggt tcaatctggg accagtgaca     3780

atcaccctgt ccgagcccag aaacatccag cagaagctgc ctccagagat catcacactg     3840

caccctaaga tcgaggaggg cttctttgac ctgatgcacg tgcagaaggt gctgtccgcc     3900

tctaccgtgt gcaagctgca gagctgcaca cacggcatcc caggcgatct gcaggtgtat     3960

cacatcggca acctgctgaa gggcgaccgg gtgaatggcc acctgatcca caagatcgag     4020

cctcacttta ataccagctg gatgtcctgg gatggctgtg atctggacta ctattgcaac     4080

atgggcgact ggccatcttg tacatacacc ggcgtgaccc agcacaatca cgccgccttc     4140

gtgaacctgc tgaatatcga gacagattat acaaagacct tccactttca cagcaagcgc     4200

gtgaccgccc acggcgatac acctcagctg gacctgaagg ccaggccaac ctacggagca     4260

ggcgagatca cagtgctggt ggaggtggcc gacatggagc tgcacaccaa gaaggtggag     4320

atcagcggcc tgaagttcgc ctccctgaca tgcaccggct gttatgcctg cagctccggc     4380

atctcctgca aggtgagaat ccacgtggat gagcctgacg agctgaccgt gcacgtgaag     4440

tctagcgatc cagacgtggt ggcagcctcc tctctgatgg cacgcaagct ggagtttggc     4500

accgattcta cattcaaggc ctttagcgcc atgcccaaga cctccctgtg cttctacatc     4560

gtggagaggg agtattgtaa gagctgctcc gaggaggata cccagaagtg cgtggacaca     4620

aagctggagc agcctcagag catcctgatc gagcacaagg gcaccatcat cggcaagcag     4680

aacgacacat gtaccgccaa ggcctcctgc tggctggagt ctgtgaagag cttcttttac     4740

ggcctgaaga acatgctggg cagcgtgttc ggcaacgtgt tcatcggcat cctgctgttt     4800

ctggccccct tcgtgctgct gatcctgttc tttatgtttg gctggaagat cctgttctgc     4860

tttaagtgct gtaggagaac caggggcctg ttcaagtaca gacacctgaa ggatgacgag     4920

gagacaggct atcggcgcat catcgagcgc ctgaacaata agaagggcaa gaacaggctg     4980

ctggacggag agcggctggc tgatagaaaa atcgcagaac tgtttagcac aaagactcac     5040

atcgga                                                                5046


<210>  2
<211>  1682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CCHFV-Glycoprotein sequence

<400>  2

His Thr Leu Leu Val Cys Phe Ile Leu Tyr Leu Gln Leu Cys Gly Leu 
1               5                   10                  15      


Gly Gly Ala His Gly Asn Asn Ser Asn Thr Thr Glu His Asn Thr Asn 
            20                  25                  30          


Thr Thr Thr Pro Gly Ser Gln Ser Pro Ser Ser Lys Pro Pro Val Ser 
        35                  40                  45              


Thr Thr Pro Ser Ile His Thr Pro Glu Ser Ser Thr Lys Pro Thr Thr 
    50                  55                  60                  


Pro Ser Glu Gly Leu Glu Gly Ser Gly Glu Val Tyr Thr Thr Pro Pro 
65                  70                  75                  80  


Asn Thr Thr Gln Gly Leu Ser Pro Ser Glu Thr Thr Pro Glu Pro Ala 
                85                  90                  95      


Thr Thr Thr Thr Thr Gln Asn Pro Thr Thr Ala Asp Pro Asp Thr Ser 
            100                 105                 110         


Ser Thr Asn Ser Thr Thr Gln Asp Thr Pro Thr Thr Val Thr Ser Pro 
        115                 120                 125             


Ser Ser Ser Pro Ser Thr Pro Ser Thr Pro Gln Gly His His Pro Pro 
    130                 135                 140                 


Val Arg Ser Leu Leu Ser Val Ser Ser Pro Gly Pro Asp Glu Lys Thr 
145                 150                 155                 160 


Thr Pro Thr Pro Ser Pro Gly Glu Ser Ser Glu Thr Pro Ser Ser His 
                165                 170                 175     


Ser Ala Ser Arg Arg Pro Pro Thr Pro Pro Thr Thr Thr Gln Val Ser 
            180                 185                 190         


Thr Glu Asn Asn Ser His Ser Thr Pro Arg Gln Ser Glu Ser Ser Gln 
        195                 200                 205             


Pro Ala Thr Ser Pro Gly Leu Met Thr Ser Pro Ala Gln Ile Leu Ser 
    210                 215                 220                 


Ala Pro Ser Ala Thr Pro Ile Ala Ile Gln Asp Thr His Pro Ser Pro 
225                 230                 235                 240 


Thr Asn Arg Ser Lys Arg Asn Leu Glu Met Glu Ile Ile Leu Thr Leu 
                245                 250                 255     


Ser Gln Gly Leu Lys Lys Tyr Tyr Gly Lys Ile Leu Lys Leu Leu His 
            260                 265                 270         


Leu Thr Leu Glu Glu Asp Thr Glu Gly Leu Leu Glu Trp Cys Lys Arg 
        275                 280                 285             


Asn Leu Gly Leu Ser Cys Asp Asp Asp Phe Phe Gln Lys Arg Ile Glu 
    290                 295                 300                 


Glu Phe Phe Ile Thr Gly Glu Gly Tyr Phe Asn Glu Val Leu Gln Phe 
305                 310                 315                 320 


Lys Thr Leu Ser Thr Leu Ser Pro Thr Glu Pro Ser His Ala Gly Leu 
                325                 330                 335     


Pro Thr Ala Glu Pro Phe Lys Ser Tyr Phe Ala Lys Gly Phe Leu Ser 
            340                 345                 350         


Ile Asp Ser Gly Tyr Phe Ser Ala Lys Cys Tyr Pro Gly Arg Ser Ser 
        355                 360                 365             


Ser Gly Leu Gln Leu Ile Asn Val Thr Gln His Pro Ala Arg Ile Ala 
    370                 375                 380                 


Glu Thr Pro Gly Pro Lys Thr Thr Ser Leu Lys Thr Ile Asn Cys Ile 
385                 390                 395                 400 


Asn Leu Arg Ala Ser Val Phe Lys Glu His Arg Glu Val Glu Ile Asn 
                405                 410                 415     


Val Leu Leu Pro Gln Ile Ala Val Asn Leu Ser Asn Cys His Val Val 
            420                 425                 430         


Ile Lys Ser His Val Cys Asp Tyr Ser Leu Asp Thr Asp Gly Pro Val 
        435                 440                 445             


Arg Leu Pro His Ile Ile His Glu Gly Thr Phe Ile Pro Gly Thr Tyr 
    450                 455                 460                 


Lys Ile Val Ile Asp Lys Lys Asn Lys Leu Asn Asp Arg Cys Thr Leu 
465                 470                 475                 480 


Val Thr Asn Cys Val Ile Lys Gly Arg Glu Val Arg Lys Gly Gln Ser 
                485                 490                 495     


Val Leu Arg Gln Tyr Lys Thr Glu Ile Lys Ile Gly Lys Ala Ser Thr 
            500                 505                 510         


Gly Ser Arg Lys Leu Leu Ser Glu Glu Pro Gly Asp Asp Cys Ile Ser 
        515                 520                 525             


Arg Thr Gln Leu Leu Arg Thr Glu Thr Ala Glu Ile His Asp Asp Asn 
    530                 535                 540                 


Tyr Gly Gly Pro Gly Asp Lys Ile Thr Ile Cys Asn Gly Ser Thr Ile 
545                 550                 555                 560 


Val Asp Gln Arg Leu Gly Ser Glu Leu Gly Cys Tyr Thr Ile Asn Arg 
                565                 570                 575     


Val Lys Ser Phe Lys Leu Cys Glu Asn Ser Ala Thr Gly Lys Thr Cys 
            580                 585                 590         


Glu Ile Asp Ser Thr Pro Val Lys Cys Arg Gln Gly Phe Cys Leu Lys 
        595                 600                 605             


Ile Thr Gln Glu Gly Arg Gly His Val Lys Leu Ser Arg Gly Ser Glu 
    610                 615                 620                 


Val Val Leu Asp Ala Cys Asp Ser Ser Cys Glu Val Met Ile Pro Lys 
625                 630                 635                 640 


Gly Thr Gly Asp Ile Leu Val Asp Cys Ser Gly Gly Gln Gln His Phe 
                645                 650                 655     


Leu Lys Asp Asn Leu Ile Asp Leu Gly Cys Pro Lys Ile Pro Leu Leu 
            660                 665                 670         


Gly Lys Met Ala Ile Tyr Ile Cys Arg Met Ser Asn His Pro Lys Thr 
        675                 680                 685             


Thr Met Ala Phe Leu Phe Trp Phe Ser Phe Gly Tyr Val Ile Thr Cys 
    690                 695                 700                 


Ile Phe Cys Lys Ala Leu Phe Tyr Leu Leu Ile Ile Ile Gly Thr Leu 
705                 710                 715                 720 


Gly Lys Arg Lys Lys Gln Tyr Arg Glu Leu Lys Pro Gln Thr Cys Thr 
                725                 730                 735     


Ile Cys Glu Thr Ala Pro Val Asn Ala Ile Asp Ala Glu Met His Asp 
            740                 745                 750         


Leu Asn Cys Ser Tyr Asn Ile Cys Pro Tyr Cys Ala Ser Arg Leu Thr 
        755                 760                 765             


Ser Asp Gly Leu Ala Arg His Val Thr Gln Cys Pro Lys Arg Lys Glu 
    770                 775                 780                 


Lys Val Glu Glu Thr Glu Leu Tyr Leu Asn Leu Glu Arg Ile Pro Trp 
785                 790                 795                 800 


Val Arg Arg Lys Leu Leu Gln Val Ser Glu Ser Thr Gly Val Ala Leu 
                805                 810                 815     


Lys Arg Ser Ser Trp Leu Ile Val Leu Leu Val Leu Leu Thr Val Ser 
            820                 825                 830         


Leu Ser Pro Val Gln Ser Ala Pro Val Gly His Gly Lys Thr Ile Glu 
        835                 840                 845             


Thr Tyr Gln Thr Arg Glu Gly Phe Thr Ser Ile Cys Leu Phe Met Leu 
    850                 855                 860                 


Gly Ser Ile Leu Phe Ile Val Ser Cys Leu Val Lys Gly Leu Val Asp 
865                 870                 875                 880 


Ser Val Ser Asn Ser Phe Phe Pro Gly Leu Ser Val Cys Lys Thr Cys 
                885                 890                 895     


Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile Glu Ser His Lys Cys Tyr 
            900                 905                 910         


Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg His Cys Ser Ala Asp Arg 
        915                 920                 925             


Glu Ile His Gln Leu His Leu Ser Ile Cys Lys Lys Arg Lys Thr Gly 
    930                 935                 940                 


Ser Asn Val Met Leu Ala Val Cys Lys Arg Met Cys Phe Arg Ala Thr 
945                 950                 955                 960 


Glu Ala Ser Ser Asn Arg Ala Leu Leu Ile Arg Ser Ile Ile Asn Thr 
                965                 970                 975     


Thr Phe Val Ile Cys Ile Leu Thr Leu Ala Ile Cys Val Val Ser Thr 
            980                 985                 990         


Ser Ala Val Glu Met Glu Asn Leu  Pro Ala Gly Thr Trp  Glu Arg Glu 
        995                 1000                 1005             


Glu Asp  Leu Thr Asn Phe Cys  His Gln Glu Cys Gln  Val Thr Glu 
    1010                 1015                 1020             


Thr Glu  Cys Leu Cys Pro Tyr  Glu Ala Leu Val Leu  Arg Lys Pro 
    1025                 1030                 1035             


Leu Phe  Leu Asp Ser Ile Val  Lys Gly Met Lys Asn  Leu Leu Asn 
    1040                 1045                 1050             


Ser Thr  Ser Leu Glu Thr Ser  Leu Ser Ile Glu Ala  Pro Trp Gly 
    1055                 1060                 1065             


Ala Ile  Asn Val Gln Ser Thr  Phe Lys Pro Thr Val  Ser Thr Ala 
    1070                 1075                 1080             


Asn Ile  Ala Leu Ser Trp Ser  Ser Val Glu His Arg  Gly Asn Lys 
    1085                 1090                 1095             


Ile Leu  Val Thr Gly Arg Ser  Glu Ser Ile Met Lys  Leu Glu Glu 
    1100                 1105                 1110             


Arg Thr  Gly Val Ser Trp Asp  Leu Gly Val Glu Asp  Ala Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Leu Thr Val Ser  Ile Met Asp Leu Ser  Gln Met Tyr 
    1130                 1135                 1140             


Ser Pro  Val Phe Glu Tyr Leu  Ser Gly Asp Arg Gln  Val Glu Glu 
    1145                 1150                 1155             


Trp Pro  Lys Ala Thr Cys Thr  Gly Asp Cys Pro Glu  Arg Cys Gly 
    1160                 1165                 1170             


Cys Thr  Ser Ser Thr Cys Leu  His Lys Glu Trp Pro  His Ser Arg 
    1175                 1180                 1185             


Asn Trp  Arg Cys Asn Pro Thr  Trp Cys Trp Gly Val  Gly Thr Gly 
    1190                 1195                 1200             


Cys Thr  Cys Cys Gly Val Asp  Val Lys Asp Leu Phe  Thr Asp His 
    1205                 1210                 1215             


Met Phe  Val Lys Trp Lys Val  Glu Tyr Ile Lys Thr  Glu Ala Ile 
    1220                 1225                 1230             


Val Cys  Val Glu Leu Thr Ser  Gln Glu Arg Gln Cys  Ser Leu Ile 
    1235                 1240                 1245             


Glu Ala  Gly Thr Arg Phe Asn  Leu Gly Pro Val Thr  Ile Thr Leu 
    1250                 1255                 1260             


Ser Glu  Pro Arg Asn Ile Gln  Gln Lys Leu Pro Pro  Glu Ile Ile 
    1265                 1270                 1275             


Thr Leu  His Pro Lys Ile Glu  Glu Gly Phe Phe Asp  Leu Met His 
    1280                 1285                 1290             


Val Gln  Lys Val Leu Ser Ala  Ser Thr Val Cys Lys  Leu Gln Ser 
    1295                 1300                 1305             


Cys Thr  His Gly Ile Pro Gly  Asp Leu Gln Val Tyr  His Ile Gly 
    1310                 1315                 1320             


Asn Leu  Leu Lys Gly Asp Arg  Val Asn Gly His Leu  Ile His Lys 
    1325                 1330                 1335             


Ile Glu  Pro His Phe Asn Thr  Ser Trp Met Ser Trp  Asp Gly Cys 
    1340                 1345                 1350             


Asp Leu  Asp Tyr Tyr Cys Asn  Met Gly Asp Trp Pro  Ser Cys Thr 
    1355                 1360                 1365             


Tyr Thr  Gly Val Thr Gln His  Asn His Ala Ala Phe  Val Asn Leu 
    1370                 1375                 1380             


Leu Asn  Ile Glu Thr Asp Tyr  Thr Lys Thr Phe His  Phe His Ser 
    1385                 1390                 1395             


Lys Arg  Val Thr Ala His Gly  Asp Thr Pro Gln Leu  Asp Leu Lys 
    1400                 1405                 1410             


Ala Arg  Pro Thr Tyr Gly Ala  Gly Glu Ile Thr Val  Leu Val Glu 
    1415                 1420                 1425             


Val Ala  Asp Met Glu Leu His  Thr Lys Lys Val Glu  Ile Ser Gly 
    1430                 1435                 1440             


Leu Lys  Phe Ala Ser Leu Thr  Cys Thr Gly Cys Tyr  Ala Cys Ser 
    1445                 1450                 1455             


Ser Gly  Ile Ser Cys Lys Val  Arg Ile His Val Asp  Glu Pro Asp 
    1460                 1465                 1470             


Glu Leu  Thr Val His Val Lys  Ser Ser Asp Pro Asp  Val Val Ala 
    1475                 1480                 1485             


Ala Ser  Ser Leu Met Ala Arg  Lys Leu Glu Phe Gly  Thr Asp Ser 
    1490                 1495                 1500             


Thr Phe  Lys Ala Phe Ser Ala  Met Pro Lys Thr Ser  Leu Cys Phe 
    1505                 1510                 1515             


Tyr Ile  Val Glu Arg Glu Tyr  Cys Lys Ser Cys Ser  Glu Glu Asp 
    1520                 1525                 1530             


Thr Gln  Lys Cys Val Asp Thr  Lys Leu Glu Gln Pro  Gln Ser Ile 
    1535                 1540                 1545             


Leu Ile  Glu His Lys Gly Thr  Ile Ile Gly Lys Gln  Asn Asp Thr 
    1550                 1555                 1560             


Cys Thr  Ala Lys Ala Ser Cys  Trp Leu Glu Ser Val  Lys Ser Phe 
    1565                 1570                 1575             


Phe Tyr  Gly Leu Lys Asn Met  Leu Gly Ser Val Phe  Gly Asn Val 
    1580                 1585                 1590             


Phe Ile  Gly Ile Leu Leu Phe  Leu Ala Pro Phe Val  Leu Leu Ile 
    1595                 1600                 1605             


Leu Phe  Phe Met Phe Gly Trp  Lys Ile Leu Phe Cys  Phe Lys Cys 
    1610                 1615                 1620             


Cys Arg  Arg Thr Arg Gly Leu  Phe Lys Tyr Arg His  Leu Lys Asp 
    1625                 1630                 1635             


Asp Glu  Glu Thr Gly Tyr Arg  Arg Ile Ile Glu Arg  Leu Asn Asn 
    1640                 1645                 1650             


Lys Lys  Gly Lys Asn Arg Leu  Leu Asp Gly Glu Arg  Leu Ala Asp 
    1655                 1660                 1665             


Arg Lys  Ile Ala Glu Leu Phe  Ser Thr Lys Thr His  Ile Gly 
    1670                 1675                 1680         


<210>  3
<211>  5106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CCHFV-Glycoprotein operably linked to IgE
       leader sequence and two stop codons

<400>  3
atggactgga cttggattct gtttctggtc gccgccgcta cccgagtgca ttctcacacc       60

ctgctggtct gttttattct gtatctgcag ctgtgcggcc tgggcggcgc ccacggaaac      120

aatagcaaca ccacagagca caacaccaat accacaaccc ctggcagcca gtccccaagc      180

tccaagcctc ccgtgagcac aaccccctct atccacaccc ctgagtctag cacaaagcca      240

acaaccccaa gcgagggcct ggagggctcc ggagaggtgt acacaacccc acccaacaca      300

acccagggcc tgtctcccag cgagacaacc cccgagcctg ccacaaccac aaccacacag      360

aacccaacca cagccgatcc cgacacatcc tctaccaatt ccaccacaca ggataccccc      420

accacagtga catctcctag ctcctctcct tctacaccaa gcacccctca gggacaccac      480

cctccagtgc gctccctgct gtctgtgagc tccccaggac cagacgagaa gaccacacct      540

accccaagcc ccggcgagtc tagcgagaca ccttcctctc acagcgccag caggaggcct      600

cccaccccac ccaccacaac ccaggtgagc accgagaaca atagccactc cacaccaagg      660

cagtccgaga gctcccagcc agccacctct ccaggcctga tgacaagccc agcacagatc      720

ctgagcgccc cttccgccac cccaatcgca atccaggata cccacccttc cccaacaaac      780

aggtctaaga gaaatctgga gatggagatc atcctgacac tgtcccaggg cctgaagaag      840

tactatggca agatcctgaa gctgctgcac ctgaccctgg aggaggacac agagggcctg      900

ctggagtggt gtaagagaaa cctgggcctg agctgcgacg atgacttctt tcagaagcgg      960

atcgaggagt tctttatcac cggcgagggc tactttaatg aggtgctgca gttcaagaca     1020

ctgtctaccc tgagccctac cgagccatct cacgcaggcc tgccaacagc agagcctttc     1080

aagagctatt ttgccaaggg cttcctgtcc atcgattctg gctacttttc cgccaagtgt     1140

tatcccggca gatctagctc cggcctgcag ctgatcaacg tgacccagca ccctgcaagg     1200

atcgcagaga caccaggacc taagacaacc tccctgaaga ccatcaactg catcaatctg     1260

agggccagcg tgttcaagga gcacagagag gtggagatca atgtgctgct gccacagatc     1320

gccgtgaacc tgagcaattg tcacgtggtc atcaagtccc acgtgtgcga ctactctctg     1380

gataccgacg gcccagtgag actgccccac atcatccacg agggcacctt catccccggc     1440

acatataaga tcgtgatcga taagaagaac aagctgaatg accggtgtac actggtgacc     1500

aactgcgtga tcaagggaag ggaggtgcgc aagggacaga gcgtgctgcg ccagtacaag     1560

accgagatca agatcggcaa ggccagcaca ggctccagga agctgctgtc cgaggagcca     1620

ggcgatgact gtatctctag gacccagctg ctgagaacag agacagccga gatccacgat     1680

gacaactacg gcggacctgg cgataagatc accatctgta atggcagcac aatcgtggac     1740

cagcgcctgg gctccgagct gggctgctat accatcaaca gggtgaagtc ttttaagctg     1800

tgcgagaata gcgccacagg caagacctgc gagatcgact ccacccctgt gaagtgtcgc     1860

cagggcttct gcctgaagat cacacaggag ggaaggggac acgtgaagct gtctcgcggc     1920

agcgaggtgg tgctggatgc ctgtgactct agctgcgaag tgatgatccc aaagggcacc     1980

ggcgatatcc tggtggactg cagcggcggc cagcagcact tcctgaagga taacctgatc     2040

gacctgggct gtcccaagat ccctctgctg ggcaagatgg ccatctacat ctgcagaatg     2100

agcaatcacc ctaagacaac catggccttc ctgttttggt tctcctttgg ctacgtgatc     2160

acctgcatct tttgtaaggc cctgttctat ctgctgatca tcatcggcac actgggcaag     2220

cggaagaagc agtatcgcga gctgaagccc cagacatgca ccatctgtga gacagcccct     2280

gtgaacgcca tcgatgccga gatgcacgac ctgaactgta gctacaatat ctgcccttat     2340

tgtgccagcc ggctgacctc cgacggcctg gcaaggcacg tgacacagtg cccaaagagg     2400

aaggagaagg tggaggagac agagctgtac ctgaatctgg agcgcatccc ctgggtgcgg     2460

aggaagctgc tgcaggtgtc tgagagcacc ggcgtggccc tgaagaggtc ctcttggctg     2520

atcgtgctgc tggtgctgct gacagtgtcc ctgtctcctg tgcagagcgc cccagtggga     2580

cacggcaaga caatcgagac atatcagaca cgggagggct ttacctccat ctgtctgttc     2640

atgctgggca gcatcctgtt catcgtgtcc tgcctggtga agggcctggt ggatagcgtg     2700

tccaactctt tctttccagg cctgtccgtg tgcaagacat gttccatcgg ctctatcaat     2760

ggctttgaga tcgagtctca caagtgctac tgtagcctgt tctgctgtcc ctattgccgg     2820

cactgttctg ccgaccgcga gatccaccag ctgcacctgt ctatctgcaa gaagaggaag     2880

accggcagca acgtgatgct ggccgtgtgc aagcggatgt gctttagggc aacagaggcc     2940

agctccaaca gggccctgct gatcagatcc atcatcaata caaccttcgt gatctgtatc     3000

ctgaccctgg ccatctgcgt ggtgagcaca tccgccgtgg agatggagaa tctgccagcc     3060

ggcacctggg agagagagga ggatctgaca aacttttgtc accaggagtg ccaggtgaca     3120

gagacagagt gcctgtgccc atacgaggcc ctggtgctga ggaagcctct gttcctggac     3180

agcatcgtga agggcatgaa gaacctgctg aattctacca gcctggagac atccctgtct     3240

atcgaggccc catggggcgc catcaacgtg cagtccacct ttaagcccac cgtgtctaca     3300

gccaatatcg ccctgagctg gtctagcgtg gagcacagag gcaacaagat cctggtgacc     3360

ggccggagcg agtccatcat gaagctggag gagagaacag gcgtgtcctg ggatctgggc     3420

gtggaggacg cctctgagag caagctgctg accgtgtcta tcatggacct gtctcagatg     3480

tacagccccg tgttcgagta tctgagcggc gatagacagg tggaggagtg gccaaaggca     3540

acatgtaccg gcgactgccc agagcggtgc ggatgtacct cctctacatg tctgcacaag     3600

gagtggcctc acagcaggaa ctggagatgt aatccaacct ggtgctgggg cgtgggaacc     3660

ggatgcacat gctgtggcgt ggatgtgaag gacctgttta cagatcacat gttcgtgaag     3720

tggaaggtgg agtacatcaa gaccgaggcc atcgtgtgcg tggagctgac atcccaggag     3780

agacagtgct ctctgatcga ggcaggaacc cggttcaatc tgggaccagt gacaatcacc     3840

ctgtccgagc ccagaaacat ccagcagaag ctgcctccag agatcatcac actgcaccct     3900

aagatcgagg agggcttctt tgacctgatg cacgtgcaga aggtgctgtc cgcctctacc     3960

gtgtgcaagc tgcagagctg cacacacggc atcccaggcg atctgcaggt gtatcacatc     4020

ggcaacctgc tgaagggcga ccgggtgaat ggccacctga tccacaagat cgagcctcac     4080

tttaatacca gctggatgtc ctgggatggc tgtgatctgg actactattg caacatgggc     4140

gactggccat cttgtacata caccggcgtg acccagcaca atcacgccgc cttcgtgaac     4200

ctgctgaata tcgagacaga ttatacaaag accttccact ttcacagcaa gcgcgtgacc     4260

gcccacggcg atacacctca gctggacctg aaggccaggc caacctacgg agcaggcgag     4320

atcacagtgc tggtggaggt ggccgacatg gagctgcaca ccaagaaggt ggagatcagc     4380

ggcctgaagt tcgcctccct gacatgcacc ggctgttatg cctgcagctc cggcatctcc     4440

tgcaaggtga gaatccacgt ggatgagcct gacgagctga ccgtgcacgt gaagtctagc     4500

gatccagacg tggtggcagc ctcctctctg atggcacgca agctggagtt tggcaccgat     4560

tctacattca aggcctttag cgccatgccc aagacctccc tgtgcttcta catcgtggag     4620

agggagtatt gtaagagctg ctccgaggag gatacccaga agtgcgtgga cacaaagctg     4680

gagcagcctc agagcatcct gatcgagcac aagggcacca tcatcggcaa gcagaacgac     4740

acatgtaccg ccaaggcctc ctgctggctg gagtctgtga agagcttctt ttacggcctg     4800

aagaacatgc tgggcagcgt gttcggcaac gtgttcatcg gcatcctgct gtttctggcc     4860

cccttcgtgc tgctgatcct gttctttatg tttggctgga agatcctgtt ctgctttaag     4920

tgctgtagga gaaccagggg cctgttcaag tacagacacc tgaaggatga cgaggagaca     4980

ggctatcggc gcatcatcga gcgcctgaac aataagaagg gcaagaacag gctgctggac     5040

ggagagcggc tggctgatag aaaaatcgca gaactgttta gcacaaagac tcacatcgga     5100

taatga                                                                5106


<210>  4
<211>  1700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, CCHFV-Glycoprotein operably linked to IgE
       leader sequence and two stop codons

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser His Thr Leu Leu Val Cys Phe Ile Leu Tyr Leu Gln Leu Cys 
            20                  25                  30          


Gly Leu Gly Gly Ala His Gly Asn Asn Ser Asn Thr Thr Glu His Asn 
        35                  40                  45              


Thr Asn Thr Thr Thr Pro Gly Ser Gln Ser Pro Ser Ser Lys Pro Pro 
    50                  55                  60                  


Val Ser Thr Thr Pro Ser Ile His Thr Pro Glu Ser Ser Thr Lys Pro 
65                  70                  75                  80  


Thr Thr Pro Ser Glu Gly Leu Glu Gly Ser Gly Glu Val Tyr Thr Thr 
                85                  90                  95      


Pro Pro Asn Thr Thr Gln Gly Leu Ser Pro Ser Glu Thr Thr Pro Glu 
            100                 105                 110         


Pro Ala Thr Thr Thr Thr Thr Gln Asn Pro Thr Thr Ala Asp Pro Asp 
        115                 120                 125             


Thr Ser Ser Thr Asn Ser Thr Thr Gln Asp Thr Pro Thr Thr Val Thr 
    130                 135                 140                 


Ser Pro Ser Ser Ser Pro Ser Thr Pro Ser Thr Pro Gln Gly His His 
145                 150                 155                 160 


Pro Pro Val Arg Ser Leu Leu Ser Val Ser Ser Pro Gly Pro Asp Glu 
                165                 170                 175     


Lys Thr Thr Pro Thr Pro Ser Pro Gly Glu Ser Ser Glu Thr Pro Ser 
            180                 185                 190         


Ser His Ser Ala Ser Arg Arg Pro Pro Thr Pro Pro Thr Thr Thr Gln 
        195                 200                 205             


Val Ser Thr Glu Asn Asn Ser His Ser Thr Pro Arg Gln Ser Glu Ser 
    210                 215                 220                 


Ser Gln Pro Ala Thr Ser Pro Gly Leu Met Thr Ser Pro Ala Gln Ile 
225                 230                 235                 240 


Leu Ser Ala Pro Ser Ala Thr Pro Ile Ala Ile Gln Asp Thr His Pro 
                245                 250                 255     


Ser Pro Thr Asn Arg Ser Lys Arg Asn Leu Glu Met Glu Ile Ile Leu 
            260                 265                 270         


Thr Leu Ser Gln Gly Leu Lys Lys Tyr Tyr Gly Lys Ile Leu Lys Leu 
        275                 280                 285             


Leu His Leu Thr Leu Glu Glu Asp Thr Glu Gly Leu Leu Glu Trp Cys 
    290                 295                 300                 


Lys Arg Asn Leu Gly Leu Ser Cys Asp Asp Asp Phe Phe Gln Lys Arg 
305                 310                 315                 320 


Ile Glu Glu Phe Phe Ile Thr Gly Glu Gly Tyr Phe Asn Glu Val Leu 
                325                 330                 335     


Gln Phe Lys Thr Leu Ser Thr Leu Ser Pro Thr Glu Pro Ser His Ala 
            340                 345                 350         


Gly Leu Pro Thr Ala Glu Pro Phe Lys Ser Tyr Phe Ala Lys Gly Phe 
        355                 360                 365             


Leu Ser Ile Asp Ser Gly Tyr Phe Ser Ala Lys Cys Tyr Pro Gly Arg 
    370                 375                 380                 


Ser Ser Ser Gly Leu Gln Leu Ile Asn Val Thr Gln His Pro Ala Arg 
385                 390                 395                 400 


Ile Ala Glu Thr Pro Gly Pro Lys Thr Thr Ser Leu Lys Thr Ile Asn 
                405                 410                 415     


Cys Ile Asn Leu Arg Ala Ser Val Phe Lys Glu His Arg Glu Val Glu 
            420                 425                 430         


Ile Asn Val Leu Leu Pro Gln Ile Ala Val Asn Leu Ser Asn Cys His 
        435                 440                 445             


Val Val Ile Lys Ser His Val Cys Asp Tyr Ser Leu Asp Thr Asp Gly 
    450                 455                 460                 


Pro Val Arg Leu Pro His Ile Ile His Glu Gly Thr Phe Ile Pro Gly 
465                 470                 475                 480 


Thr Tyr Lys Ile Val Ile Asp Lys Lys Asn Lys Leu Asn Asp Arg Cys 
                485                 490                 495     


Thr Leu Val Thr Asn Cys Val Ile Lys Gly Arg Glu Val Arg Lys Gly 
            500                 505                 510         


Gln Ser Val Leu Arg Gln Tyr Lys Thr Glu Ile Lys Ile Gly Lys Ala 
        515                 520                 525             


Ser Thr Gly Ser Arg Lys Leu Leu Ser Glu Glu Pro Gly Asp Asp Cys 
    530                 535                 540                 


Ile Ser Arg Thr Gln Leu Leu Arg Thr Glu Thr Ala Glu Ile His Asp 
545                 550                 555                 560 


Asp Asn Tyr Gly Gly Pro Gly Asp Lys Ile Thr Ile Cys Asn Gly Ser 
                565                 570                 575     


Thr Ile Val Asp Gln Arg Leu Gly Ser Glu Leu Gly Cys Tyr Thr Ile 
            580                 585                 590         


Asn Arg Val Lys Ser Phe Lys Leu Cys Glu Asn Ser Ala Thr Gly Lys 
        595                 600                 605             


Thr Cys Glu Ile Asp Ser Thr Pro Val Lys Cys Arg Gln Gly Phe Cys 
    610                 615                 620                 


Leu Lys Ile Thr Gln Glu Gly Arg Gly His Val Lys Leu Ser Arg Gly 
625                 630                 635                 640 


Ser Glu Val Val Leu Asp Ala Cys Asp Ser Ser Cys Glu Val Met Ile 
                645                 650                 655     


Pro Lys Gly Thr Gly Asp Ile Leu Val Asp Cys Ser Gly Gly Gln Gln 
            660                 665                 670         


His Phe Leu Lys Asp Asn Leu Ile Asp Leu Gly Cys Pro Lys Ile Pro 
        675                 680                 685             


Leu Leu Gly Lys Met Ala Ile Tyr Ile Cys Arg Met Ser Asn His Pro 
    690                 695                 700                 


Lys Thr Thr Met Ala Phe Leu Phe Trp Phe Ser Phe Gly Tyr Val Ile 
705                 710                 715                 720 


Thr Cys Ile Phe Cys Lys Ala Leu Phe Tyr Leu Leu Ile Ile Ile Gly 
                725                 730                 735     


Thr Leu Gly Lys Arg Lys Lys Gln Tyr Arg Glu Leu Lys Pro Gln Thr 
            740                 745                 750         


Cys Thr Ile Cys Glu Thr Ala Pro Val Asn Ala Ile Asp Ala Glu Met 
        755                 760                 765             


His Asp Leu Asn Cys Ser Tyr Asn Ile Cys Pro Tyr Cys Ala Ser Arg 
    770                 775                 780                 


Leu Thr Ser Asp Gly Leu Ala Arg His Val Thr Gln Cys Pro Lys Arg 
785                 790                 795                 800 


Lys Glu Lys Val Glu Glu Thr Glu Leu Tyr Leu Asn Leu Glu Arg Ile 
                805                 810                 815     


Pro Trp Val Arg Arg Lys Leu Leu Gln Val Ser Glu Ser Thr Gly Val 
            820                 825                 830         


Ala Leu Lys Arg Ser Ser Trp Leu Ile Val Leu Leu Val Leu Leu Thr 
        835                 840                 845             


Val Ser Leu Ser Pro Val Gln Ser Ala Pro Val Gly His Gly Lys Thr 
    850                 855                 860                 


Ile Glu Thr Tyr Gln Thr Arg Glu Gly Phe Thr Ser Ile Cys Leu Phe 
865                 870                 875                 880 


Met Leu Gly Ser Ile Leu Phe Ile Val Ser Cys Leu Val Lys Gly Leu 
                885                 890                 895     


Val Asp Ser Val Ser Asn Ser Phe Phe Pro Gly Leu Ser Val Cys Lys 
            900                 905                 910         


Thr Cys Ser Ile Gly Ser Ile Asn Gly Phe Glu Ile Glu Ser His Lys 
        915                 920                 925             


Cys Tyr Cys Ser Leu Phe Cys Cys Pro Tyr Cys Arg His Cys Ser Ala 
    930                 935                 940                 


Asp Arg Glu Ile His Gln Leu His Leu Ser Ile Cys Lys Lys Arg Lys 
945                 950                 955                 960 


Thr Gly Ser Asn Val Met Leu Ala Val Cys Lys Arg Met Cys Phe Arg 
                965                 970                 975     


Ala Thr Glu Ala Ser Ser Asn Arg Ala Leu Leu Ile Arg Ser Ile Ile 
            980                 985                 990         


Asn Thr Thr Phe Val Ile Cys Ile  Leu Thr Leu Ala Ile  Cys Val Val 
        995                 1000                 1005             


Ser Thr  Ser Ala Val Glu Met  Glu Asn Leu Pro Ala  Gly Thr Trp 
    1010                 1015                 1020             


Glu Arg  Glu Glu Asp Leu Thr  Asn Phe Cys His Gln  Glu Cys Gln 
    1025                 1030                 1035             


Val Thr  Glu Thr Glu Cys Leu  Cys Pro Tyr Glu Ala  Leu Val Leu 
    1040                 1045                 1050             


Arg Lys  Pro Leu Phe Leu Asp  Ser Ile Val Lys Gly  Met Lys Asn 
    1055                 1060                 1065             


Leu Leu  Asn Ser Thr Ser Leu  Glu Thr Ser Leu Ser  Ile Glu Ala 
    1070                 1075                 1080             


Pro Trp  Gly Ala Ile Asn Val  Gln Ser Thr Phe Lys  Pro Thr Val 
    1085                 1090                 1095             


Ser Thr  Ala Asn Ile Ala Leu  Ser Trp Ser Ser Val  Glu His Arg 
    1100                 1105                 1110             


Gly Asn  Lys Ile Leu Val Thr  Gly Arg Ser Glu Ser  Ile Met Lys 
    1115                 1120                 1125             


Leu Glu  Glu Arg Thr Gly Val  Ser Trp Asp Leu Gly  Val Glu Asp 
    1130                 1135                 1140             


Ala Ser  Glu Ser Lys Leu Leu  Thr Val Ser Ile Met  Asp Leu Ser 
    1145                 1150                 1155             


Gln Met  Tyr Ser Pro Val Phe  Glu Tyr Leu Ser Gly  Asp Arg Gln 
    1160                 1165                 1170             


Val Glu  Glu Trp Pro Lys Ala  Thr Cys Thr Gly Asp  Cys Pro Glu 
    1175                 1180                 1185             


Arg Cys  Gly Cys Thr Ser Ser  Thr Cys Leu His Lys  Glu Trp Pro 
    1190                 1195                 1200             


His Ser  Arg Asn Trp Arg Cys  Asn Pro Thr Trp Cys  Trp Gly Val 
    1205                 1210                 1215             


Gly Thr  Gly Cys Thr Cys Cys  Gly Val Asp Val Lys  Asp Leu Phe 
    1220                 1225                 1230             


Thr Asp  His Met Phe Val Lys  Trp Lys Val Glu Tyr  Ile Lys Thr 
    1235                 1240                 1245             


Glu Ala  Ile Val Cys Val Glu  Leu Thr Ser Gln Glu  Arg Gln Cys 
    1250                 1255                 1260             


Ser Leu  Ile Glu Ala Gly Thr  Arg Phe Asn Leu Gly  Pro Val Thr 
    1265                 1270                 1275             


Ile Thr  Leu Ser Glu Pro Arg  Asn Ile Gln Gln Lys  Leu Pro Pro 
    1280                 1285                 1290             


Glu Ile  Ile Thr Leu His Pro  Lys Ile Glu Glu Gly  Phe Phe Asp 
    1295                 1300                 1305             


Leu Met  His Val Gln Lys Val  Leu Ser Ala Ser Thr  Val Cys Lys 
    1310                 1315                 1320             


Leu Gln  Ser Cys Thr His Gly  Ile Pro Gly Asp Leu  Gln Val Tyr 
    1325                 1330                 1335             


His Ile  Gly Asn Leu Leu Lys  Gly Asp Arg Val Asn  Gly His Leu 
    1340                 1345                 1350             


Ile His  Lys Ile Glu Pro His  Phe Asn Thr Ser Trp  Met Ser Trp 
    1355                 1360                 1365             


Asp Gly  Cys Asp Leu Asp Tyr  Tyr Cys Asn Met Gly  Asp Trp Pro 
    1370                 1375                 1380             


Ser Cys  Thr Tyr Thr Gly Val  Thr Gln His Asn His  Ala Ala Phe 
    1385                 1390                 1395             


Val Asn  Leu Leu Asn Ile Glu  Thr Asp Tyr Thr Lys  Thr Phe His 
    1400                 1405                 1410             


Phe His  Ser Lys Arg Val Thr  Ala His Gly Asp Thr  Pro Gln Leu 
    1415                 1420                 1425             


Asp Leu  Lys Ala Arg Pro Thr  Tyr Gly Ala Gly Glu  Ile Thr Val 
    1430                 1435                 1440             


Leu Val  Glu Val Ala Asp Met  Glu Leu His Thr Lys  Lys Val Glu 
    1445                 1450                 1455             


Ile Ser  Gly Leu Lys Phe Ala  Ser Leu Thr Cys Thr  Gly Cys Tyr 
    1460                 1465                 1470             


Ala Cys  Ser Ser Gly Ile Ser  Cys Lys Val Arg Ile  His Val Asp 
    1475                 1480                 1485             


Glu Pro  Asp Glu Leu Thr Val  His Val Lys Ser Ser  Asp Pro Asp 
    1490                 1495                 1500             


Val Val  Ala Ala Ser Ser Leu  Met Ala Arg Lys Leu  Glu Phe Gly 
    1505                 1510                 1515             


Thr Asp  Ser Thr Phe Lys Ala  Phe Ser Ala Met Pro  Lys Thr Ser 
    1520                 1525                 1530             


Leu Cys  Phe Tyr Ile Val Glu  Arg Glu Tyr Cys Lys  Ser Cys Ser 
    1535                 1540                 1545             


Glu Glu  Asp Thr Gln Lys Cys  Val Asp Thr Lys Leu  Glu Gln Pro 
    1550                 1555                 1560             


Gln Ser  Ile Leu Ile Glu His  Lys Gly Thr Ile Ile  Gly Lys Gln 
    1565                 1570                 1575             


Asn Asp  Thr Cys Thr Ala Lys  Ala Ser Cys Trp Leu  Glu Ser Val 
    1580                 1585                 1590             


Lys Ser  Phe Phe Tyr Gly Leu  Lys Asn Met Leu Gly  Ser Val Phe 
    1595                 1600                 1605             


Gly Asn  Val Phe Ile Gly Ile  Leu Leu Phe Leu Ala  Pro Phe Val 
    1610                 1615                 1620             


Leu Leu  Ile Leu Phe Phe Met  Phe Gly Trp Lys Ile  Leu Phe Cys 
    1625                 1630                 1635             


Phe Lys  Cys Cys Arg Arg Thr  Arg Gly Leu Phe Lys  Tyr Arg His 
    1640                 1645                 1650             


Leu Lys  Asp Asp Glu Glu Thr  Gly Tyr Arg Arg Ile  Ile Glu Arg 
    1655                 1660                 1665             


Leu Asn  Asn Lys Lys Gly Lys  Asn Arg Leu Leu Asp  Gly Glu Arg 
    1670                 1675                 1680             


Leu Ala  Asp Arg Lys Ile Ala  Glu Leu Phe Ser Thr  Lys Thr His 
    1685                 1690                 1695             


Ile Gly  
    1700 


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 1

<400>  5

Gly Asn Gly Leu Val Asp Thr Phe Thr Asn Ser Tyr Ser Phe Cys 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 2

<400>  6

Asp Thr Phe Thr Asn Ser Tyr Ser Phe Cys Glu Ser Val Pro Asn 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 3

<400>  7

Thr Ala Ala Leu Ser Asn Lys Val Leu Ala Glu Tyr Lys Val Pro 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 4

<400>  8

Asp Glu Val Asp Arg Ala Ser Ala Asp Ser Met Ile Thr Asn Leu 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 5

<400>  9

Ala Gln Ile Asp Thr Ala Phe Ser Ser Tyr Tyr Trp Leu Tyr Lys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 6

<400>  10

Lys Met Lys Lys Ala Leu Leu Ser Thr Pro Met Lys Trp Gly Lys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 7

<400>  11

Asp Asp Ala Ala Gln Gly Ser Gly His Thr Lys Ser Ile Leu Asn 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 8

<400>  12

Met Asp Ile Val Ala Ser Glu His Leu Leu His Gln Ser Leu Val 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 9

<400>  13

Ser Glu His Leu Leu His Gln Ser Leu Val Gly Lys Gln Ser Pro 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Peptide 10

<400>  14

Ser Pro Phe Gln Asn Ala Tyr Asn Val Lys Gly Asn Ala Thr Ser 
1               5                   10                  15  


